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Alexander Lucas

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Alexander H Lucas; K Rittenhouse-Olson; M Kronenberg; M A Apicella; D Wang; J R Schreiber; C E Taylor
Carbohydrate Moieties as Vaccine Candidates: meeting summary.
Alexander H Lucas; Michael A Apicella; Christopher E Taylor
Carbohydrate moieties as vaccine candidates.
Taia T Wang; Alexander H Lucas
The capsule of Bacillus anthracis behaves as a thymus-independent type 2 antigen.

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All Publications

2010: Alexander H Lucas; K Rittenhouse-Olson; M Kronenberg; M A Apicella; D Wang; J R Schreiber; C E Taylor
Carbohydrate Moieties as Vaccine Candidates: meeting summary.
Vaccine 2010;28(4):1121-31.
2005: Alexander H Lucas; Michael A Apicella; Christopher E Taylor
Carbohydrate moieties as vaccine candidates.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41(5):705-12.
2004: Taia T Wang; Alexander H Lucas
The capsule of Bacillus anthracis behaves as a thymus-independent type 2 antigen.
Infection and immunity 2004;72(9):5460-3.
2004: Taia T Wang; Patricia F Fellows; Terrance Leighton; Alexander H Lucas
Induction of opsonic antibodies to the gamma-D-glutamic acid capsule of Bacillus anthracis by immunization with a synthetic peptide-carrier protein conjugate.
FEMS immunology and medical microbiology 2004;40(3):231-7.
2003: Alexander H Lucas; Gary R McLean; Donald Reason; Adam P O'Connor; Mistique C Felton; Karen D Moulton
Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type B polysaccharide: expression of canonical variable regions and their variants in vaccinated infants.
Clinical immunology (Orlando, Fla.) 2003;108(2):119-27.
2003: Leyu Liu; Alexander H Lucas
IGH V3-23*01 and its allele V3-23*03 differ in their capacity to form the canonical human antibody combining site specific for the capsular polysaccharide of Haemophilus influenzae type b.
Immunogenetics 2003;55(5):336-8.
2002: Jianhui Zhou; Kathleen R Lottenbach; Stephen J Barenkamp; Alexander H Lucas; Donald Reason
Recurrent variable region gene usage and somatic mutation in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F.
Infection and immunity 2002;70(8):4083-91.
2001: Donald Reason; A P O'Connor; Alexander H Lucas
Structural determinants of the human idiotype HibId-1.
Journal of molecular recognition : JMR 2001;14(6):393-400.
2001: Gregory R Moe; Patricia Zuno-Mitchell; S S Lee; Alexander H Lucas; Dan M Granoff
Functional activity of anti-Neisserial surface protein A monoclonal antibodies against strains of Neisseria meningitidis serogroup B.
Infection and immunity 2001;69(6):3762-71.
2001: Samuel T Test; Joyce K Mitsuyoshi; C C Connolly; Alexander H Lucas
Increased immunogenicity and induction of class switching by conjugation of complement C3d to pneumococcal serotype 14 capsular polysaccharide.
Infection and immunity 2001;69(5):3031-40.
2001: Alexander H Lucas; Dan M Granoff
Imperfect memory and the development of Haemophilus influenzae type B disease.
The Pediatric infectious disease journal 2001;20(3):235-9.
2001: Alexander H Lucas; Karen D Moulton; V R Tang; Donald Reason
Combinatorial library cloning of human antibodies to Streptococcus pneumoniae capsular polysaccharides: variable region primary structures and evidence for somatic mutation of Fab fragments specific for capsular serotypes 6B, 14, and 23F.
Infection and immunity 2001;69(2):853-64.
1999: Alexander H Lucas; Donald Reason
Polysaccharide vaccines as probes of antibody repertoires in man.
Immunological reviews 1999;171():89-104.
1999: W R Usinger; Alexander H Lucas
Avidity as a determinant of the protective efficacy of human antibodies to pneumococcal capsular polysaccharides.
Infection and immunity 1999;67(5):2366-70.
1999: Donald Reason; T C Wagner; V R Tang; Karen D Moulton; Alexander H Lucas
Polysaccharide binding potential of the human A2 or A18 kappa light chain homologues.
Infection and immunity 1999;67(2):994-7.
1998: Alexander H Lucas; Karen D Moulton; Donald Reason
Role of kappa II-A2 light chain CDR-3 junctional residues in human antibody binding to the Haemophilus influenzae type b polysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3776-80.
1998: Alexander H Lucas; Donald Reason
Aging and the immune response to the Haemophilus influenzae type b capsular polysaccharide: retention of the dominant idiotype and antibody function in the elderly.
Infection and immunity 1998;66(4):1752-4.
1997: Alexander H Lucas; Dan M Granoff; Robert Mandrell; C C Connolly; A S Shan; Douglas C Powers
Oligoclonality of serum immunoglobulin G antibody responses to Streptococcus pneumoniae capsular polysaccharide serotypes 6B, 14, and 23F.
Infection and immunity 1997;65(12):5103-9.
1997: E Kantor; Jay S Luxenberg; Alexander H Lucas; Dan M Granoff
Phase I study of the immunogenicity and safety of conjugated Hemophilus influenzae type b vaccines in the elderly.
Vaccine 1997;15(2):129-32.
1997: Donald Reason; Alexander H Lucas
Functional expression of the IGKV A18b gene and its idiotypic cross-reactivity with the A2 variable region.
Immunogenetics 1997;45(5):343-4.
1997: Donald Reason; T C Wagner; Alexander H Lucas
Human Fab fragments specific for the Haemophilus influenzae b polysaccharide isolated from a bacteriophage combinatorial library use variable region gene combinations and express an idiotype that mirrors in vivo expression.
Infection and immunity 1997;65(1):261-6.
1996: S T Singer; J E Addiego; Donald Reason; Alexander H Lucas
T lymphocyte proliferative responses induced by recombinant factor VIII in hemophilia A patients with inhibitors.
Thrombosis and haemostasis 1996;76(1):17-22.
1995: Dan M Granoff; Alexander H Lucas
Laboratory correlates of protection against Haemophilus influenzae type b disease. Importance of assessment of antibody avidity and immunologic memory.
Annals of the New York Academy of Sciences 1995;754():278-88.
1995: F H Azmi; Alexander H Lucas; H L Spiegelberg; Dan M Granoff
Human immunoglobulin M paraproteins cross-reactive with Neisseria meningitidis group B polysaccharide and fetal brain.
Infection and immunity 1995;63(5):1906-13.
1995: Alexander H Lucas; Dan M Granoff
Functional differences in idiotypically defined IgG1 anti-polysaccharide antibodies elicited by vaccination with Haemophilus influenzae type B polysaccharide-protein conjugates.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):4195-202.
1994: Alexander H Lucas; J W Larrick; Donald Reason
Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide.
Infection and immunity 1994;62(9):3873-80.
1994: Donald Reason; M Y Kitamura; Alexander H Lucas
Induction of a protective human polysaccharide-specific antibody response in hu-PBL SCID mice by idiotypic vaccination.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(10):5009-13.
1994: F H Azmi; Alexander H Lucas; H V Raff; Dan M Granoff
Variable region sequences and idiotypic expression of a protective human immunoglobulin M antibody to capsular polysaccharides of Neisseria meningitidis group B and Escherichia coli K1.
Infection and immunity 1994;62(5):1776-86.
1994: H L Spiegelberg; L Beck; H P Kocher; W C Fanslow; Alexander H Lucas
Role of interleukin-4 in human immunoglobulin E formation in hu-PBL-SCID mice.
The Journal of clinical investigation 1994;93(2):711-7.
1993: Dan M Granoff; S J Holmes; Michael Osterholm; J E McHugh; Alexander H Lucas; E L Anderson; R B Belshe; J L Jacobs; FB Medley; Trudy V Murphy
Induction of immunologic memory in infants primed with Haemophilus influenzae type b conjugate vaccines.
The Journal of infectious diseases 1993;168(3):663-71.
1993: Dan M Granoff; P G Shackelford; S J Holmes; Alexander H Lucas
Variable region expression in the antibody responses of infants vaccinated with Haemophilus influenzae type b polysaccharide-protein conjugates. Description of a new lambda light chain-associated idiotype and the relation between idiotype expression, avidity, and vaccine formulation. The Collaborative Vaccine Study Group.
The Journal of clinical investigation 1993;91(3):788-96.
1993: Alexander H Lucas; F H Azmi; C M Mink; Dan M Granoff
Age-dependent V region expression in the human antibody response to the Haemophilus influenzae type b polysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(5):2056-61.
1993: Dan M Granoff; M H Rathore; S J Holmes; P D Granoff; Alexander H Lucas
Effect of immunity to the carrier protein on antibody responses to Haemophilus influenzae type b conjugate vaccines.
Vaccine 1993;11 Suppl 1():S46-51.
1993: Donald Reason; Alexander H Lucas
Content and dynamics of the human antibody variable region repertoire to the Haemophilus influenzae type b polysaccharide.
Springer seminars in immunopathology 1993;15(2-3):119-37.
1992: Alexander H Lucas; T E Siff; K H Trujillo; M Y Kitamura
Vaccine-induced human antibody responses to the Haemophilus influenzae b polysaccharide in severe combined immunodeficient mice engrafted with human leukocytes.
Pediatric research 1992;32(1):132-5.
1991: Alexander H Lucas; R J Langley; Dan M Granoff; M H Nahm; M Y Kitamura; M G Scott
An idiotypic marker associated with a germ-line encoded kappa light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide.
The Journal of clinical investigation 1991;88(6):1811-8.
1991: S J Holmes; Alexander H Lucas; Michael Osterholm; J E Froeschle; Dan M Granoff
Immunoglobulin deficiency and idiotype expression in children developing Haemophilus influenzae type b disease after vaccination with conjugate vaccine. The Collaborative Study Group.
JAMA : the journal of the American Medical Association 1991;266(14):1960-5.
1991: Gregg J Silverman; Alexander H Lucas
Variable region diversity in human circulating antibodies specific for the capsular polysaccharide of Haemophilus influenzae type b. Preferential usage of two types of VH3 heavy chains.
The Journal of clinical investigation 1991;88(3):911-20.
1990: Alexander H Lucas; Dan M Granoff
A major crossreactive idiotype associated with human antibodies to the Haemophilus influenzae b polysaccharide. Expression in relation to age and immunoglobulin G subclass.
The Journal of clinical investigation 1990;85(4):1158-66.
1990: Alexander H Lucas
IgG subclass-restricted immune responses to allergens.
Springer seminars in immunopathology 1990;12(4):385-400.
1989: P Lebrun; Alexander H Lucas; D T McKenzie; H L Spiegelberg
Interleukin 4 acts on both high- and low-density murine B cell subpopulations to induce IgE and IgG1 synthesis in vitro.
International archives of allergy and applied immunology 1989;88(1-2):108-10.
1988: Alexander H Lucas
Expression of crossreactive idiotypes by human antibodies specific for the capsular polysaccharide of Hemophilus influenzae B.
The Journal of clinical investigation 1988;81(2):480-6.
1986: RL Rubin; F L Tang; Alexander H Lucas; H L Spiegelberg; Eng M Tan
IgG subclasses of anti-tetanus toxoid antibodies in adult and newborn normal subjects and in patients with systemic lupus erythematosus, Sjogren's syndrome, and drug-induced autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(8):2522-7.