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Andreas Luch

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Patrick Tarnow; Tewes Tralau; Danele Hunecke; Andreas Luch
Effects of triclocarban on the transcription of estrogen, androgen and aryl hydrocarbon receptor responsive genes in human breast cancer cells.
Nadine Mathieu; Nina Kaczmarek; Andreas Luch; Peter Rüthemann; Hanspeter Naegeli
DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIH.
Joep Brinkmann; Doris Genkinger; Frank Henkler; Christoph Hutzler; Manfred Liebsch; Timo Otter; Kristin Stolpmann; Susanne Trappe; Udo Bock; Andreas Luch
Metabolically competent human skin models: activation and genotoxicity of benzo[a]pyrene.

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All Publications

2013: Patrick Tarnow; Tewes Tralau; Danele Hunecke; Andreas Luch
Effects of triclocarban on the transcription of estrogen, androgen and aryl hydrocarbon receptor responsive genes in human breast cancer cells.
Toxicology in vitro : an international journal published in association with BIBRA 2013;27(5):1467-75.
2013: Nadine Mathieu; Nina Kaczmarek; Andreas Luch; Peter Rüthemann; Hanspeter Naegeli
DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIH.
Current biology : CB 2013;23(3):204-12.
2013: Joep Brinkmann; Doris Genkinger; Frank Henkler; Christoph Hutzler; Manfred Liebsch; Timo Otter; Kristin Stolpmann; Susanne Trappe; Udo Bock; Andreas Luch
Metabolically competent human skin models: activation and genotoxicity of benzo[a]pyrene.
Toxicological sciences : an official journal of the Society of Toxicology 2013;131(2):351-9.
2013: Katell Fiselier; Florian Grundböck; Christoph Hutzler; Oliver Kappenstein; Andreas Luch; Karla Pfaff; Karsten Schön; Koni Grob
Development of a manual method for the determination of mineral oil in foods and paperboard.
Journal of chromatography. A 2013;1271(1):192-200.
2013: Tzutzuy Ramirez; Bjoern Riefke; Mark Seymour; Nigel Skinner; Lena Smirnova; Bennard van Ravenzwaay; Elwin Verheij; Silvia Wagner; Andreas Luch; Fozia Noor; Erik Peter; Frederic Y Bois; Malcolm R Clench; Muireann Coen; Mardas Daneshian; Beth Donley; Drew R Ekman; Eric Fabian; Steven M Fischer; Claude Guillou; Thomas Hartung; Joachim Heuer; Helena T Hogberg; Harald Jungnickel; Hennicke Kamp; Hector C Keun; Gerhard Krennrich; Eckart Krupp; Marcel Leist
Metabolomics in toxicology and preclinical research.
ALTEX 2013;30(2):209-25.
2012: Frank Henkler; Carsten Kneuer; Andreas Luch; T Platzek; Jutta Tentschert; Tewes Tralau; Andrea Haase; Mario E Götz
Risk assessment of nanomaterials in cosmetics: a European union perspective.
Archives of toxicology 2012;86(11):1641-6.
2012: Tewes Tralau; Andreas Luch
"Drugs on oxygen": an update and perspective on the role of cytochrome P450 testing in pharmacology.
Expert opinion on drug metabolism & toxicology 2012;8(11):1357-62.
2012: Tewes Tralau; Manfred Liebsch; Michael Oelgeschläger; Ralph Pirow; Christian Riebeling; Andrea Seiler; Andreas Luch
Wind of change challenges toxicological regulators.
Environmental health perspectives 2012;120(11):1489-94.
2012: Anke Visan; Dana Sittner; Birgitta Slawik; Konrad Gulich; Katrin Hayess; Andreas Luch; Michael Oelgeschläger; Elena E Pohl; Christian Riebeling; Andrea Seiler
Neural differentiation of mouse embryonic stem cells as a tool to assess developmental neurotoxicity in vitro.
Neurotoxicology 2012;33(5):1135-46.
2012: Jens Schubert; Jana Bewersdorff; Volkmar Heinke; Andreas Luch; Thomas G Schulz
Waterpipe smoking: the role of humectants in the release of toxic carbonyls.
Archives of toxicology 2012;86(8):1309-16.
2012: Andreas Luch
Waterpipe smoking: a new tobacco pandemic entailing severe health risks?
Archives of toxicology 2012;86(8):1161-2.
2012: Tewes Tralau; Andreas Luch
Drug-mediated toxicity: illuminating the 'bad' in the test tube by means of cellular assays?
Trends in pharmacological sciences 2012;33(7):353-64.
2012: A Haase; P Graf; A Mantion; W Meier; J Plendl; Andreas Taubert; A F Thuenemann; Andreas Luch
A novel type of silver nanoparticles and their advantages in toxicity testing in cell culture systems.
Archives of toxicology 2012;86(7):1089-98.
2012: Harald Jungnickel; J Tentschert; Andreas Luch
Monitoring oxidative stress biomarkers in the lipidome: is there a roadmap for "human inspection"?
Current molecular medicine 2012;12(6):716-31.
2012: Christian Riebeling; Katrin Hayess; Andreas Luch; Annelieke K Peters; Horst Spielmann; Margino Steemans; Andrea Seiler
Assaying embryotoxicity in the test tube: current limitations of the embryonic stem cell test (EST) challenging its applicability domain.
Critical reviews in toxicology 2012;42(5):443-64.
2012: Andrea Haase; Andreas Luch; Alexandre Mantion; Wolfgang P Meier; Johanna Plendl; Stephanie Rott; Andreas Taubert; Andreas F Thünemann; Philipp Graf; Georg Reiser
Effects of silver nanoparticles on primary mixed neural cell cultures: uptake, oxidative stress and acute calcium responses.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(2):457-68.
2012: M Peiser; T Platzek; Andreas Luch
[Assessment of the sensitizing potency of cosmetic ingredients and commodities. How will the ingredients of cosmetics and commodities be tested in Europe today and tomorrow?].
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 2012;55(3):373-9.
2012: M Peiser; T Platzek; T Rustemeyer; A Schnuch; Tewes Tralau; R J Vandebriel; I R White; H I Maibach; S F Martin; H F Merk; A M Api; J H E Arts; D A Basketter; T L Diepgen; J English; R C Fuhlbrigge; Anthony Gaspari; J Heidler; J D Johansen; Ann-Therese Karlberg; I Kimber; J P Lepoittevin; Manfred Liebsch; Andreas Luch
Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Current knowledge assembled at an international workshop at BfR, Germany.
Cellular and molecular life sciences : CMLS 2012;69(5):763-81.
2012: Rao L Divi; Andreas Luch; Mukesh Verma; Brinda Mahadevan
CYP1B1 detection.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2012;Chapter 4():Unit 4.38.
2012: Jens Schubert; Jana Bewersdorff; Andreas Luch; Thomas G Schulz
Waterpipe smoke: a considerable source of human exposure against furanic compounds.
Analytica chimica acta 2012;709():105-12.
2012: Manuel Hitzler; Andreas Luch; Otto Majdic; Grit Ebert; Guido Heine; Margitta Worm; Matthias Peiser
Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy.
PloS one 2012;7(10):e46776.
2012: K Stolpmann; Harald Wajant; Christoph Hutzler; Andreas Luch; S Salzmann; J Brinkmann; E Fritsche; D Genkinger; Frank Henkler
Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis.
Cell death & disease 2012;3():e388.
2012: Lena Smirnova; Alexandra Sittka; Andreas Luch
On the role of low-dose effects and epigenetics in toxicology.
EXS 2012;101():499-550.
2012: Harald Jungnickel; Andreas Luch
A personalized life: biomarker monitoring from cradle to grave.
EXS 2012;101():471-98.
2012: Andrea Haase; Jutta Tentschert; Andreas Luch
Nanomaterials: a challenge for toxicological risk assessment?
EXS 2012;101():219-50.
2012: Frank Henkler; Kristin Stolpmann; Andreas Luch
Exposure to polycyclic aromatic hydrocarbons: bulky DNA adducts and cellular responses.
EXS 2012;101():107-31.
2012: Oliver Kappenstein; Andreas Luch; Bärbel Vieth; Karla Pfaff
Toxicologically relevant phthalates in food.
EXS 2012;101():87-106.
2011: Alexandre Mantion; Admir Mašić; Wolfgang Meier; Pierre Rabu; Ovidiu Ersen; Ileana Florea; Philipp Graf; Andrea Haase; Andreas Luch; Andreas F Thünemann; Andreas Taubert
Biomimetic synthesis of chiral erbium-doped silver/peptide/silica core-shell nanoparticles (ESPN).
Nanoscale 2011;3(12):5168-79.
2011: I Masuck; Christoph Hutzler; O Jann; Andreas Luch
Inhalation exposure of children to fragrances present in scented toys.
Indoor air 2011;21(6):501-11.
2011: Andrea Seiler; Tewes Tralau; Manfred Liebsch; Michael Oelgeschläger; Ralph Pirow; Christian Riebeling; Andreas Luch
Developmental toxicity testing in the 21st century: the sword of Damocles shattered by embryonic stem cell assays?
Archives of toxicology 2011;85(11):1361-72.
2011: Jia Fei; Andreas Glas; Nina Kaczmarek; Andreas Luch; Thomas Carell; Hanspeter Naegeli
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA.
PLoS biology 2011;9(10):e1001183.
2011: Ines Masuck; Christoph Hutzler; Andreas Luch
Estimation of dermal and oral exposure of children to scented toys: analysis of the migration of fragrance allergens by dynamic headspace GC-MS.
Journal of separation science 2011;34(19):2686-96.
2011: Christoph Hutzler; Andreas Luch; Johannes G Filser
Analysis of carcinogenic polycyclic aromatic hydrocarbons in complex environmental mixtures by LC-APPI-MS/MS.
Analytica chimica acta 2011;702(2):218-24.
2011: Bernd Schäfer; Jutta Tentschert; Andreas Luch
Nanosilver in consumer products and human health: more information required!
Environmental science & technology 2011;45(17):7589-90; author reply 7593-5.
2011: Jens Schubert; Oliver Kappenstein; Andreas Luch; Thomas G Schulz
Analysis of primary aromatic amines in the mainstream waterpipe smoke using liquid chromatography-electrospray ionization tandem mass spectrometry.
Journal of chromatography. A 2011;1218(33):5628-37.
2011: Manfred Liebsch; Sarah Adler; Daniel Butzke; Barbara Grune; Michael Oelgeschläger; Ralph Pirow; Christian Riebeling; Andrea Seiler; Andreas Luch
Alternatives to animal testing: current status and future perspectives.
Archives of toxicology 2011;85(8):841-58.
2011: Christian Riebeling; Katharina Schlechter; Roland Buesen; Horst Spielmann; Andreas Luch; Andrea Seiler
Defined culture medium for stem cell differentiation: applicability of serum-free conditions in the mouse embryonic stem cell test.
Toxicology in vitro : an international journal published in association with BIBRA 2011;25(4):914-21.
2011: Robert LANDSIEDEL; Eric Fabian; Tewes Tralau; Andreas Luch
Chemical toxicity testing in vitro using cytochrome P450-expressing cell lines, such as human CYP1B1.
Nature protocols 2011;6(5):677-87.
2011: Andrea Haase; Harald Jungnickel; Heinrich F Arlinghaus; Felix Draude; Sebastian Galla; Mario E Goetz; Philipp Graf; Alexandre Mantion; Admir Masic; Wolfgang Meier; Johanna Plendl; Andreas Taubert; Jutta Tentschert; Andreas F Thünemann; Andreas Luch
Application of laser postionization secondary neutral mass spectrometry/time-of-flight secondary ion mass spectrometry in nanotoxicology: visualization of nanosilver in human macrophages and cellular responses.
ACS nano 2011;5(4):3059-68.
2011: Hans Mielke; Klaus Abraham; Mario Götz; Bärbel Vieth; Alfonso Lampen; Andreas Luch; Ursula Gundert-Remy
Physiologically based toxicokinetic modelling as a tool to assess target organ toxicity in route-to-route extrapolation--the case of coumarin.
Toxicology letters 2011;202(2):100-10.
2011: Christian Riebeling; Ralph Pirow; Klaus Becker; Roland Buesen; Daniel Eikel; Johanna Kaltenhäuser; Frauke Meyer; Heinz Nau; Birgitta Slawik; Anke Visan; Jutta Volland; Horst Spielmann; Andreas Luch; Andrea Seiler
The embryonic stem cell test as tool to assess structure-dependent teratogenicity: the case of valproic acid.
Toxicological sciences : an official journal of the Society of Toxicology 2011;120(2):360-70.
2011: Philipp Graf; Alexandre Mantion; Andrea Haase; Andreas F Thünemann; Admir Masić; Wolfgang Meier; Andreas Luch; Andreas Taubert
Silicification of peptide-coated silver nanoparticles--A Biomimetic soft chemistry approach toward chiral hybrid core-shell materials.
ACS nano 2011;5(2):820-33.
2011: Ursula G Sauer; Carsten Kneuer; Jutta Tentschert; Thomas Wächter; Michael Schroeder; Daniel Butzke; Andreas Luch; Manfred Liebsch; Barbara Grune; Mario E Götz
A knowledge-based search engine to navigate the information thicket of nanotoxicology.
Regulatory toxicology and pharmacology : RTP 2011;59(1):47-52.
2011: Frank Henkler; Andreas Luch
Adverse health effects of environmental chemical agents through non-genotoxic mechanisms.
Journal of epidemiology and community health 2011;65(1):1-3.
2010: Stefan F Martin; Philipp Esser; Sonja Schmucker; Lisa Dietz; Dean J Naisbitt; B Kevin Park; Marc Vocanson; Jean-Francois Nicolas; Monika Keller; Werner J Pichler; Matthias Peiser; Andreas Luch; Reinhard Wanner; Enrico Maggi; Andrea Cavani; Thomas Rustemeyer; Anne Richter; Hermann-Josef Thierse; Federica Sallusto
T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays.
Cellular and molecular life sciences : CMLS 2010;67(24):4171-84.
2010: Sarah Adler; Gerd Bicker; Hans Bigalke; Christopher Bishop; Jörg Blümel; Dirk Dressler; Joan Fitzgerald; Frank Gessler; Heide Heuschen; Birgit Kegel; Andreas Luch; Catherine Milne; Andrew Pickett; Heidemarie Ratsch; Irmela Ruhdel; Dorothea Sesardic; Martin Stephens; Gerhard Stiens; Peter D Thornton; René Thürmer; Martin Vey; Horst Spielmann; Barbara Grune; Manfred Liebsch
The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting.
Alternatives to laboratory animals : ATLA 2010;38(4):315-30.
2010: Ines Masuck; Christoph Hutzler; Andreas Luch
Investigations on the emission of fragrance allergens from scented toys by means of headspace solid-phase microextraction gas chromatography-mass spectrometry.
Journal of chromatography. A 2010;1217(18):3136-43.
2010: Ariane Kretlow; Daniel Butzke; Mario E Goetz; Barbara Grune; Marlies Halder; Frank Henkler; Manfred Liebsch; Rainer Nobiling; Michael Oelgeschlaeger; Kurt Reifenberg; Bernd Schaefer; Andrea Seiler; Andreas Luch
Implementation and enforcement of the 3Rs principle in the field of transgenic animals used for scientific purposes. Report and recommendations of the BfR expert workshop, May 18-20, 2009, Berlin, Germany.
ALTEX 2010;27(2):117-34.
2010: Andreas Luch
Mechanistic insights on spider neurotoxins.
EXS 2010;100():293-315.
2010: Daniel Butzke; Andreas Luch
High-molecular weight protein toxins of marine invertebrates and their elaborate modes of action.
EXS 2010;100():213-32.
2010: Andreas Luch
Molecular, clinical and environmental toxicology. Volume 2: clinical toxicology. Preface.
EXS 2010;100():XI-XIII.
2009: Roland Buesen; Elke Genschow; Birgitta Slawik; Anke Visan; Horst Spielmann; Andreas Luch; Andrea Seiler
Embryonic stem cell test remastered: comparison between the validated EST and the new molecular FACS-EST for assessing developmental toxicity in vitro.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(2):389-400.
2009: Andreas Luch
On the impact of the molecule structure in chemical carcinogenesis.
EXS 2009;99():151-79.
2009: Andreas Luch
Molecular, clinical and environmental toxicology. Preface.
EXS 2009;99():XI-XIV.
2008: Mario E Goetz; Andreas Luch
Reactive species: a cell damaging rout assisting to chemical carcinogens.
Cancer letters 2008;266(1):73-83.
2008: Lauren A Courter; Andreas Luch; Tamara Musafia-Jeknic; Volker M Arlt; Kay Fischer; Robert J Bildfell; Cliff Pereira; David H Phillips; Miriam C Poirier; William M Baird
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
Cancer letters 2008;265(1):135-47.
2007: Thomas Heberer; Monika Lahrssen-Wiederholt; Helmut Schafft; Klaus Abraham; Hildegard Pzyrembel; Klaus Juergen Henning; Marianna Schauzu; Juliane Braeunig; Mario Goetz; Lars Niemann; Ursula Gundert-Remy; Andreas Luch; Bernd Appel; Ursula Banasiak; Gaby-Fleur Böl; Alfonso Lampen; Reiner Wittkowski; Andreas Hensel
Zero tolerances in food and animal feed -- are there any scientific alternatives? A European point of view on an international controversy.
Toxicology letters 2007;175(1-3):118-35.
2007: Brinda Mahadevan; Charis P Marston; Andreas Luch; Wan-Mohaiza Dashwood; Eric Brooks; Cliff Pereira; Johannes Doehmer; William M Baird
Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar.
International journal of cancer. Journal international du cancer 2007;120(6):1161-8.
2007: Brinda Mahadevan; Andreas Luch; Jennifer Atkin; Melanie Haynes; Tuan Nguyen; William M Baird
Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture.
Journal of biochemical and molecular toxicology 2007;21(3):101-9.
2006: Brinda Mahadevan; Andreas Luch; Jennifer Atkin; Tuan Nguyen; Arun K Sharma; Shantu Amin; William M Baird
Investigation of the genotoxicity of dibenzo[c,p]chrysene in human carcinoma MCF-7 cells in culture.
Chemico-biological interactions 2006;164(3):181-91.
2006: Wolfgang Schober; Andreas Luch; Volker J Soballa; Gottfried Raab; John J Stegeman; Johannes Doehmer; Jürgen Jacob; Albrecht Seidel
On the species-specific biotransformation of dibenzo[a,l]pyrene.
Chemico-biological interactions 2006;161(1):37-48.
2006: Brian B Haines; Chun Jeih Ryu; Sandy Chang; Alexei Protopopov; Andreas Luch; Yun Hee Kang; Dobrin D Draganov; Maria F Fragoso; Sang Gi Paik; Hyo Jeong Hong; Ronald A DePinho; Jianzhu Chen
Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations.
Cancer cell 2006;9(2):109-20.
2006: Andreas Luch
The mode of action of organic carcinogens on cellular structures.
EXS 2006;(96):65-95.
2005: Andreas Luch
Chemicals as tumor-inducing agents.
Discovery medicine 2005;5(29):472-7.
2005: Brinda Mahadevan; Andreas Luch; Claudia F Bravo; Jennifer Atkin; Linda B Steppan; Cliff Pereira; Nancy Kerkvliet; William M Baird
Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo.
Cancer letters 2005;227(1):25-32.
2005: Andreas Luch
Nature and nurture - lessons from chemical carcinogenesis.
Nature reviews. Cancer 2005;5(2):113-25.
2004: Jung-Hoon Yoon; Ahmad Besaratinia; Zhaohui Feng; Moon-shong Tang; Shantu Amin; Andreas Luch; Gerd P Pfeifer
DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells.
Cancer research 2004;64(20):7321-8.
2004: Karl L Platt; Hans P Dienes; Manuela Tommasone; Andreas Luch
Tumor formation in the neonatal mouse bioassay indicates that the potent carcinogen dibenzo[def,p]chrysene (dibenzo[a,l]pyrene) is activated in vivo via its trans-11,12-dihydrodiol.
Chemico-biological interactions 2004;148(1-2):27-36.
2003: Brinda Mahadevan; Wan-Mohaiza Dashwood; Andreas Luch; Arta Pecaj; Johannes Doehmer; Albrecht Seidel; Cliff Pereira; William M Baird
Mutations induced by (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells.
Environmental and molecular mutagenesis 2003;41(2):131-9.
2002: Jeroen Buters; Brinda Mahadevan; Leticia Quintanilla-Martinez; Frank J Gonzalez; Helmut Greim; William M Baird; Andreas Luch
Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.
Chemical research in toxicology 2002;15(9):1127-35.
2002: Andreas Luch
Cell cycle control and cell division: implications for chemically induced carcinogenesis.
Chembiochem : a European journal of chemical biology 2002;3(6):506-16.
2001: Brinda Mahadevan; Andreas Luch; Albrecht Seidel; J C Pelling; William M Baird
Effects of the (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo.
Carcinogenesis 2001;22(1):161-9.
2000: VJ Melendez-Colon; Andreas Luch; Albrecht Seidel; William M Baird
Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures.
Chemical research in toxicology 2000;13(1):10-7.
1999: VJ Melendez-Colon; Andreas Luch; Albrecht Seidel; William M Baird
Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites.
Carcinogenesis 1999;20(10):1885-91.
1999: Andreas Luch; S Kishiyama; Albrecht Seidel; Johannes Doehmer; Helmut Greim; William M Baird
The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1.
Cancer research 1999;59(18):4603-9.
1999: Johannes Doehmer; Jeroen Buters; Andreas Luch; Volker J Soballa; William M Baird; Hilary G Morrison; J J Stegeman; Alan J Townsend; William F Greenlee; H R Glatt; Albrecht Seidel; Jürgen Jacob; Helmut Greim
Molecular studies on the toxifying effects by genetically engineered cytochromes P450.
Drug metabolism reviews 1999;31(2):423-35.
1999: Andreas Luch; K Kudla; Albrecht Seidel; Johannes Doehmer; Helmut Greim; William M Baird
The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determined the effect on the proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7.
Carcinogenesis 1999;20(5):859-65.
1999: Andreas Luch; Wolfgang Schober; Volker J Soballa; G Raab; Helmut Greim; Jürgen Jacob; Johannes Doehmer; Albrecht Seidel
Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells.
Chemical research in toxicology 1999;12(4):353-64.
1999: VJ Melendez-Colon; Andreas Luch; Albrecht Seidel; William M Baird
Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites.
Cancer research 1999;59(7):1412-6.
1999: Andreas Luch; H Friesel; Albrecht Seidel; Karl L Platt
Tumor-initiating activity of the (+)-(S,S)- and (-)-(R,R)- enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene in mouse skin.
Cancer letters 1999;136(2):119-28.
1998: Andreas Luch; Stephanie L Coffing; Y M Tang; A Schneider; Volker J Soballa; Helmut Greim; Colin R Jefcoate; Albrecht Seidel; William F Greenlee; William M Baird; Johannes Doehmer
Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene.
Chemical research in toxicology 1998;11(6):686-95.
1998: Ryszard Jankowiak; Freek Ariese; A Hewer; Andreas Luch; D Zamzow; N C Hughes; D Phillips; Albrecht Seidel; Karl L Platt; F Oesch; Gerald J Small
Structure, conformations, and repair of DNA adducts from dibenzo[a, l]pyrene: 32P-postlabeling and fluorescence studies.
Chemical research in toxicology 1998;11(6):674-85.
1998: Andreas Luch; Karl L Platt; Albrecht Seidel
Synthesis of fjord region tetraols and their use in hepatic biotransformation studies of dihydrodiols of benzo[c]chrysene, benzo[g]chrysene and dibenzo[a,l]pyrene.
Carcinogenesis 1998;19(4):639-48.
1998: Berno Tanner; Jan G Hengstler; Andreas Luch; R Meinert; E Kreutz; M Arand; C Wilkens; M Hofmann; Franz Oesch; Paul Georg Knapstein; R Becker
C-myc mRNA expression in epithelial ovarian carcinomas in relation to estrogen receptor status, metastatic spread, survival time, FIGO stage, and histologic grade and type.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1998;17(1):66-74.
1997: VJ Melendez-Colon; C A Smith; Albrecht Seidel; Andreas Luch; Karl L Platt; William M Baird
Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo[a,l]pyrene or its diol epoxides.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13542-7.
1997: Andreas Luch; Albrecht Seidel; Hansruedi Glatt; Karl L Platt
Metabolic activation of the (+)-S,S- and (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: stereoselectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells.
Chemical research in toxicology 1997;10(10):1161-70.
1997: S L Ralston; Stephanie L Coffing; Albrecht Seidel; Andreas Luch; Karl L Platt; William M Baird
Stereoselective activation of dibenzo[a,l]pyrene and its trans-11,12-dihydrodiol to fjord region 11,12-diol 13,14-epoxides in a human mammary carcinoma MCF-7 cell-mediated V79 cell mutation assay.
Chemical research in toxicology 1997;10(6):687-93.
1997: Ryszard Jankowiak; Freek Ariese; D Zamzow; Andreas Luch; H Kroth; Albrecht Seidel; Gerald J Small
Conformational studies of stereoisomeric tetrols derived from syn- and anti-dibenzo[a,l]pyrene diol epoxides.
Chemical research in toxicology 1997;10(6):677-86.
1995: S L Ralston; Albrecht Seidel; Andreas Luch; Karl L Platt; William M Baird
Stereoselective activation of dibenzo[a,l]pyrene to (-)-anti (11R,12S,13S,14R)- and (+)-syn(11S,12R,13S,14R)-11,12-diol-13,14-epoxides which bind extensively to deoxyadenosine residues of DNA in the human mammary carcinoma cell line MCF-7.
Carcinogenesis 1995;16(12):2899-907.
1994: Andreas Luch; Hansruedi Glatt; Karl L Platt; Franz Oesch; Albrecht Seidel
Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo[a,l]pyrene.
Carcinogenesis 1994;15(11):2507-16.
1994: S L Ralston; H H Lau; Albrecht Seidel; Andreas Luch; Karl L Platt; William M Baird
The potent carcinogen dibenzo[a,l]pyrene is metabolically activated to fjord-region 11,12-diol 13,14-epoxides in human mammary carcinoma MCF-7 cell cultures.
Cancer research 1994;54(4):887-90.