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Thomas Ludwig

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Luzhou Xing; Hong Zhang; Ottavio Arancio; Julia Gittler; Chyuan-Sheng Lin; Thomas Ludwig; Vundavalli V Murty; Martha Salas; WAYNE SILVERMAN; Benjamin Tycko
Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1).
Reena Shakya; Matthias Szabolcs; Benjamin Tycko; Timothy C Wang; Jenna Brooks; Angelica Cullo; Justine Davies; Tamas Gonda; Steffen Hirsch; Samuel Kim; Kenneth Olive; Michael Quante; Martha Salas; Thomas Ludwig
Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.
Kenta Yamamoto; Christopher J Bakkenist; Richard L Dubois; Wenxia Jiang; Chyuan-Sheng Lin; Xiangyu Liu; Thomas Ludwig; Yunyue Wang; Shan Zha
Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.

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All Publications

2013: Luzhou Xing; Hong Zhang; Ottavio Arancio; Julia Gittler; Chyuan-Sheng Lin; Thomas Ludwig; Vundavalli V Murty; Martha Salas; WAYNE SILVERMAN; Benjamin Tycko
Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1).
Mammalian genome : official journal of the International Mammalian Genome Society 2013;24(1-2):30-43.
2013: Reena Shakya; Matthias Szabolcs; Benjamin Tycko; Timothy C Wang; Jenna Brooks; Angelica Cullo; Justine Davies; Tamas Gonda; Steffen Hirsch; Samuel Kim; Kenneth Olive; Michael Quante; Martha Salas; Thomas Ludwig
Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.
Cancer research 2013;73(2):885-96.
2012: Kenta Yamamoto; Christopher J Bakkenist; Richard L Dubois; Wenxia Jiang; Chyuan-Sheng Lin; Xiangyu Liu; Thomas Ludwig; Yunyue Wang; Shan Zha
Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.
The Journal of cell biology 2012;198(3):305-13.
2012: Tongyuan Li; Thomas Ludwig; Minjia Tan; Yingming Zhao; Richard Baer; Le Jiang; Ning Kon; Wei Gu
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence.
Cell 2012;149(6):1269-83.
2011: Reena Shakya; Matthias Szabolcs; Kandasamy Ravi; Colleen R Reczek; Latarsha J Reid; Richard Baer; Francesca Cole; Dirk G deRooij; Dieter Egli; James B Hicks; Steffen Hirsch; Maria Jasin; Chyuan-Sheng Lin; Thomas Ludwig
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.
Science (New York, N.Y.) 2011;334(6055):525-8.
2011: Liang Lei; Adam M Sonabend; Paolo Guarnieri; Craig Soderquist; Thomas Ludwig; Steven Rosenfeld; Jeffrey N Bruce; Peter Canoll
Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype.
PloS one 2011;6(5):e20041.
2010: Foon Wu-Baer; Thomas Ludwig; Richard Baer
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function.
Molecular and cellular biology 2010;30(11):2787-98.
2010: N Kon; Y Kobayashi; M Li; Christopher Brooks; Thomas Ludwig; W Gu
Inactivation of HAUSP in vivo modulates p53 function.
Oncogene 2010;29(9):1270-9.
2010: Fengtao Su; Lubomir B Smilenov; Thomas Ludwig; Libin Zhou; Jiayun Zhu; Guangming Zhou; Eric J Hall
Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis.
Radiation oncology (London, England) 2010;5():15.
2009: Xudong Zhao; Domenico D' Arca; Wei Keat Lim; Manisha Brahmachary; Maria Stella Carro; Thomas Ludwig; Carlos Cordon Cardo; Francois Guillemot; Kenneth Aldape; Andrea Califano; Antonio Iavarone; Anna Lasorella
The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.
Developmental cell 2009;17(2):210-21.
2008: Latarsha J Reid; Reena Shakya; Ami P Modi; Maria Lokshin; Jiin-Tsuey Cheng; Maria Jasin; Richard Baer; Thomas Ludwig
E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(52):20876-81.
2008: Lao H Saal; Sofia K Gruvberger-Saal; Camilla Persson; Kristina Lövgren; Mervi Jumppanen; Johan Staaf; Göran Jönsson; Maira M Pires; Matthew Maurer; Karolina Holm; Susan Koujak; Shivakumar Subramaniyam; Johan Vallon-Christersson; Håkan Olsson; Tao Su; Lorenzo Memeo; Thomas Ludwig; Stephen Ethier; Morten Krogh; Matthias Szabolcs; Vundavalli Murty; Jorma Isola; Hanina Hibshoosh; Ramon Parsons; Ake Borg
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.
Nature genetics 2008;40(1):102-7.
2007: Marsha Laufer; Subhadra V Nandula; Ami P Modi; Shuang Wang; Maria Jasin; Vundavalli Murty; Thomas Ludwig; Richard Baer
Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair.
The Journal of biological chemistry 2007;282(47):34325-33.
2007: Kaiying Guo; Julie E McMinn; Thomas Ludwig; Yi-Hao Yu; Guoqing Yang; Lulu Chen; Daniella Loh; Cai Li; Streamson Chua Jr.; Yiying Zhang
Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities.
Endocrinology 2007;148(8):3987-97.
2006: Ulf Klein; Stefano Casola; Giorgio Cattoretti; Qiong Shen; Mariel Lia; Tongwei Mo; Thomas Ludwig; Klaus Rajewsky; Riccardo Dalla-Favera
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.
Nature immunology 2006;7(7):773-82.
2005: Carl de Luca; Timothy J Kowalski; Yiying Zhang; Joel K Elmquist; Charlotte Lee; Manfred W Kilimann; Thomas Ludwig; Shun Mei Liu; Streamson Chua Jr.
Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.
The Journal of clinical investigation 2005;115(12):3484-93.
2005: Julie E McMinn; Shun Mei Liu; Hong Liu; Ioannis Dragatsis; Paula Dietrich; Thomas Ludwig; Carol N Boozer; Streamson Chua Jr.
Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility.
American journal of physiology. Endocrinology and metabolism 2005;289(3):E403-11.
2005: Atish Choudhury; Hong Xu; Ami P Modi; Wenzhu Zhang; Thomas Ludwig; Richard Baer
Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells.
The Journal of biological chemistry 2005;280(26):24669-79.
2005: Rachael Easton; Han Cho; Kristin Roovers; Diana W Shineman; Moshe Mizrahi; Mark S Forman; Virginia M-Y Lee; Matthias Szabolcs; Ron de Jong; Tilman Oltersdorf; Thomas Ludwig; Argiris Efstratiadis; Morris J Birnbaum
Role for Akt3/protein kinase Bgamma in attainment of normal brain size.
Molecular and cellular biology 2005;25(5):1869-78.
2005: Roberto Coppari; Masumi Ichinose; Charlotte E Lee; Abigail E Pullen; Christopher D Kenny; Robert A McGovern; Vinsee Tang; Shun Mei Liu; Thomas Ludwig; Streamson Chua Jr.; Bradford B Lowell; Joel K Elmquist
The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.
Cell metabolism 2005;1(1):63-72.
2004: Julie E McMinn; Shun Mei Liu; Ioannis Dragatsis; Paula Dietrich; Thomas Ludwig; Sandra Eiden; Streamson Chua Jr.
An allelic series for the leptin receptor gene generated by CRE and FLP recombinase.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(9):677-85.
2004: Katerina Politi; Ana Kljuic; Matthias Szabolcs; Peter Fisher; Thomas Ludwig; Argiris Efstratiadis
'Designer' tumors in mice.
Oncogene 2004;23(8):1558-65.
2004: Katerina Politi; Matthias Szabolcs; Peter Fisher; Ana Kljuic; Thomas Ludwig; Argiris Efstratiadis
A mouse model of uterine leiomyosarcoma.
The American journal of pathology 2004;164(1):325-36.
2003: Ellen E McCarthy; Julide Tok Celebi; Richard Baer; Thomas Ludwig
Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability.
Molecular and cellular biology 2003;23(14):5056-63.
2002: Dale Frank; Weiwei Fortino; Lorraine Clark; Raymond Musalo; Wenxian Wang; Anjana Saxena; Chi-Ming Li; Wolf Reik; Thomas Ludwig; Benjamin Tycko
Placental overgrowth in mice lacking the imprinted gene Ipl.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7490-5.
2002: Richard Baer; Thomas Ludwig
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity.
Current opinion in genetics & development 2002;12(1):86-91.
2001: Thomas Ludwig; Peter Fisher; Vundavalli Murty; Argiris Efstratiadis
Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice.
Oncogene 2001;20(30):3937-48.
2001: Thomas Ludwig; Peter Fisher; S Ganesan; Argiris Efstratiadis
Tumorigenesis in mice carrying a truncating Brca1 mutation.
Genes & development 2001;15(10):1188-93.
1997: J Eggenschwiler; Thomas Ludwig; Peter Fisher; P A Leighton; Shirley M Tilghman; Argiris Efstratiadis
Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes.
Genes & development 1997;11(23):3128-42.
1997: Thomas Ludwig; Deborah L Chapman; Virginia E Papaioannou; Argiris Efstratiadis
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.
Genes & development 1997;11(10):1226-41.
1996: Thomas Ludwig; J Eggenschwiler; P Fisher; Augustine D'ercole; Marsha L Davenport; Argiris Efstratiadis
Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds.
Developmental biology 1996;177(2):517-35.
1995: C R Brunetti; Rae Lyn Burke; Bernard Hoflack; Thomas Ludwig; K S Dingwell; David C Johnson
Role of mannose-6-phosphate receptors in herpes simplex virus entry into cells and cell-to-cell transmission.
Journal of virology 1995;69(6):3517-28.
1995: Thomas Ludwig; Roland Le Borgne; B Hoflack
Roles for mannose-6-phosphate receptors in lysosomal enzyme sorting, IGF-II binding and clathrin-coat assembly.
Trends in cell biology 1995;5(5):202-6.
1995: R Metzger; M Bader; Thomas Ludwig; C Berberich; B Bunnemann; D Ganten
Expression of the mouse and rat mas proto-oncogene in the brain and peripheral tissues.
FEBS letters 1995;357(1):27-32.
1994: Thomas Ludwig; H Munier-Lehmann; U Bauer; Mike Hollinshead; Catherine E Ovitt; Peter Lobel; Bernard Hoflack
Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts.
The EMBO journal 1994;13(15):3430-7.
1994: Thomas Ludwig; K Tenscher; J Remmler; Bernard Hoflack; Peter Lobel
Cloning and sequencing of cDNAs encoding the full-length mouse mannose 6-phosphate/insulin-like growth factor II receptor.
Gene 1994;142(2):311-2.
1993: Thomas Ludwig; Catherine E Ovitt; U Bauer; Mike Hollinshead; J Remmler; Peter Lobel; U Rüther; Bernard Hoflack
Targeted disruption of the mouse cation-dependent mannose 6-phosphate receptor results in partial missorting of multiple lysosomal enzymes.
The EMBO journal 1993;12(13):5225-35.
1992: Thomas Ludwig; U Rüther; R Metzger; N G Copeland; N A Jenkins; Peter Lobel; Bernard Hoflack
Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization.
The Journal of biological chemistry 1992;267(17):12211-9.
1991: Thomas Ludwig; Gareth Griffiths; Bernard Hoflack
Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells.
The Journal of cell biology 1991;115(6):1561-72.
1990: S Méresse; Thomas Ludwig; R Frank; Bernard Hoflack
Phosphorylation of the cytoplasmic domain of the bovine cation-independent mannose 6-phosphate receptor. Serines 2421 and 2492 are the targets of a casein kinase II associated to the Golgi-derived HAI adaptor complex.
The Journal of biological chemistry 1990;265(31):18833-42.
1990: J Scheel; R Matteoni; Thomas Ludwig; Bernard Hoflack; Thomas E Kreis
Microtubule depolymerization inhibits transport of cathepsin D from the Golgi apparatus to lysosomes.
Journal of cell science 1990;96 ( Pt 4)():711-20.
1990: J Tooze; Mike Hollinshead; Thomas Ludwig; K Howell; Bernard Hoflack; H Kern
In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome.
The Journal of cell biology 1990;111(2):329-45.