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Robert Luedtke

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TOP 3
Aixiao Li; Shihong Li; Robert R Luedtke; Maninder Malik; Yogesh Mishra; David E Reichert; Michelle Taylor; Qi Wang; Robert H Mach
Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands.
Robert R Luedtke; Cathy Bell-Horner; Glenn H Dillon; Suzy A Griffin; Ren-Qi Huang; Yogesh Mishra; David E Reichert; Michelle Taylor; Suwanna Vangveravong; Qi Wang; Robert H Mach
Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds.
Amy Hauck Newman; Katherine Pongetti; Ashwini K Banala; Thijs Beuming; Jianjing Cao; Prashant Donthamsetti; Jonathan A Javitch; Alex LaBounty; Benjamin Levy; Robert R Luedtke; Mayako Michino; Lei Shi
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

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All Publications

2013: Aixiao Li; Shihong Li; Robert R Luedtke; Maninder Malik; Yogesh Mishra; David E Reichert; Michelle Taylor; Qi Wang; Robert H Mach
Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands.
Bioorganic & medicinal chemistry 2013;21(11):2988-98.
2012: Robert R Luedtke; Cathy Bell-Horner; Glenn H Dillon; Suzy A Griffin; Ren-Qi Huang; Yogesh Mishra; David E Reichert; Michelle Taylor; Suwanna Vangveravong; Qi Wang; Robert H Mach
Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds.
ACS chemical neuroscience 2012;3(12):1050-62.
2012: Amy Hauck Newman; Katherine Pongetti; Ashwini K Banala; Thijs Beuming; Jianjing Cao; Prashant Donthamsetti; Jonathan A Javitch; Alex LaBounty; Benjamin Levy; Robert R Luedtke; Mayako Michino; Lei Shi
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.
Journal of medicinal chemistry 2012;55(15):6689-99.
2012: Robert R Luedtke; Robert H Mach; Evelyn Perez; Zhude Tu; Suwanna Vangveravong; Shao-Hua Yang; Ran Liu; James W Simpkins
Neuroprotective effects of high affinity Σ1 receptor selective compounds.
Brain research 2012;1441():17-26.
2011: Wei Wang; Jinbin Xu; Jinquan Cui; Xiaoxia Lu; Robert R Luedtke; Prashanth K Padakanti; Stanley M Parsons; Nigam P Rath; Zhude Tu
Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ1 receptors.
Journal of medicinal chemistry 2011;54(15):5362-72.
2011: Robert H Mach; Zhude Tu; Jinbin Xu; Shihong Li; Lynne A Jones; Michelle Taylor; Robert R Luedtke; Colin P Derdeyn; Joel S Perlmutter; Mark A Mintun
Endogenous dopamine (DA) competes with the binding of a radiolabeled D₃ receptor partial agonist in vivo: a positron emission tomography study.
Synapse (New York, N.Y.) 2011;65(8):724-32.
2011: Zhude Tu; Jinbin Xu; Wenhua Chu; Lynne A Jones; Shihong Li; Robert R Luedtke; Robert H Mach
Effect of cyclosporin A on the uptake of D3-selective PET radiotracers in rat brain.
Nuclear medicine and biology 2011;38(5):725-39.
2011: Suwanna Vangveravong; Zhanbin Zhang; Michelle Taylor; Melissa Bearden; Jinbin Xu; Jinquan Cui; Wei Wang; Robert R Luedtke; Robert H Mach
Synthesis and characterization of selective dopamine D₂ receptor ligands using aripiprazole as the lead compound.
Bioorganic & medicinal chemistry 2011;19(11):3502-11.
2011: Ashwini K Banala; Benjamin A Levy; Sameer S Khatri; Cheryse A Furman; Rebecca A Roof; Yogesh Mishra; Suzy A Griffin; David R Sibley; Robert R Luedtke; Amy Hauck Newman
N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.
Journal of medicinal chemistry 2011;54(10):3581-94.
2011: B L Blaylock; R W Gould; A Banala; P Grundt; Robert R Luedtke; Amy Hauck Newman; Michael A Nader
Influence of cocaine history on the behavioral effects of Dopamine D(3) receptor-selective compounds in monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(5):1104-13.
2011: Zhude Tu; Shihong Li; Jinquan Cui; Jinbin Xu; Michelle Taylor; David Ho; Robert R Luedtke; Robert H Mach
Synthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands.
Journal of medicinal chemistry 2011;54(6):1555-64.
2011: Lindsay R Riddle; Rakesh Kumar; Suzy A Griffin; Peter Grundt; Amy Hauck Newman; Robert R Luedtke
Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on L-dopa dependent animal involuntary movements in rats.
Neuropharmacology 2011;60(2-3):284-94.
2011: Morvarid Karimi; Stephen M Moerlein; Tom O Videen; Robert R Luedtke; Michelle Taylor; Robert H Mach; Joel S Perlmutter
Decreased striatal dopamine receptor binding in primary focal dystonia: a D2 or D3 defect?
Movement disorders : official journal of the Movement Disorder Society 2011;26(1):100-6.
2010: Suwanna Vangveravong; Michelle Taylor; Jinbin Xu; Jinquan Cui; Wesley Calvin; Sonja Babic; Robert R Luedtke; Robert H Mach
Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.
Bioorganic & medicinal chemistry 2010;18(14):5291-300.
2010: Jinbin Xu; Babak Hassanzadeh; Wenhua Chu; Zhude Tu; Lynne A Jones; Robert R Luedtke; Joel S Perlmutter; Mark A Mintun; Robert H Mach
[3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamen.
Synapse (New York, N.Y.) 2010;64(6):449-59.
2010: Michelle Taylor; Peter Grundt; Suzy A Griffin; Amy Hauck Newman; Robert R Luedtke
Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways.
Synapse (New York, N.Y.) 2010;64(3):251-66.
2009: Rakesh Kumar; Lindsay R Riddle; Suzy A Griffin; Wenhua Chu; Suwanna Vangveravong; Janet Neisewander; Robert H Mach; Robert R Luedtke
Evaluation of D2 and D3 dopamine receptor selective compounds on L-dopa-dependent abnormal involuntary movements in rats.
Neuropharmacology 2009;56(6-7):956-69.
2009: Rakesh Kumar; Lindsay Riddle; Suzy A Griffin; Peter Grundt; Amy Hauck Newman; Robert R Luedtke
Evaluation of the D3 dopamine receptor selective antagonist PG01037 on L-dopa-dependent abnormal involuntary movements in rats.
Neuropharmacology 2009;56(6-7):944-55.
2009: Amy Hauck Newman; Peter Grundt; George Cyriac; Jeffrey Deschamps; Michelle Taylor; Rakesh Kumar; David Ho; Robert R Luedtke
N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.
Journal of medicinal chemistry 2009;52(8):2559-70.
2008: Noel M Paul; Michelle Taylor; Rakesh Kumar; Jeffrey Deschamps; Robert R Luedtke; Amy Hauck Newman
Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.
Journal of medicinal chemistry 2008;51(19):6095-109.
2007: Peter Grundt; Katherine M Prevatt; Jianjing Cao; Michelle Taylor; Christina Z Floresca; Ji-Kyung Choi; Bruce G Jenkins; Robert R Luedtke; Amy Hauck Newman
Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents.
Journal of medicinal chemistry 2007;50(17):4135-46.
2007: Peter Grundt; Sarah Little Jane Husband; Robert R Luedtke; Michelle Taylor; Amy Hauck Newman
Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR.
Bioorganic & medicinal chemistry letters 2007;17(3):745-9.
2006: Suwanna Vangveravong; Elizabeth McElveen; Michelle Taylor; Jinbin Xu; Zhude Tu; Robert R Luedtke; Robert H Mach
Synthesis and characterization of selective dopamine D2 receptor antagonists.
Bioorganic & medicinal chemistry 2006;14(3):815-25.
2005: Peter Grundt; Erin Carlson; Jianjing Cao; Christina J Bennett; Elizabeth McElveen; Michelle Taylor; Robert R Luedtke; Amy Hauck Newman
Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor.
Journal of medicinal chemistry 2005;48(3):839-48.
2005: Wenhua Chu; Zhude Tu; Elizabeth McElveen; Jinbin Xu; Michelle Taylor; Robert R Luedtke; Robert H Mach
Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.
Bioorganic & medicinal chemistry 2005;13(1):77-87.
2004: Robert H Mach; Yunsheng Huang; Rebekah A Freeman; Li Wu; Suwanna Vangveravong; Robert R Luedtke
Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands.
Bioorganic & medicinal chemistry letters 2004;14(1):195-202.
2003: Amy Hauck Newman; Jianjing Cao; Christina J Bennett; Michael J Robarge; Rebekah A Freeman; Robert R Luedtke
N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(13):2179-83.
2003: Robert H Mach; Yunsheng Huang; Rebekah A Freeman; Li Wu; Suwanna Blair; Robert R Luedtke
Synthesis of 2-(5-bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues and their binding affinities for dopamine D2, D3, and D4 receptors.
Bioorganic & medicinal chemistry 2003;11(2):225-33.
2001: Yunsheng Huang; Robert R Luedtke; Rebekah A Freeman; Li Wu; Robert H Mach
Synthesis of 2-(2,3-dimethoxyphenyl)-4-(aminomethyl)imidazole analogues and their binding affinities for dopamine D(2) and D(3) receptors.
Bioorganic & medicinal chemistry 2001;9(12):3113-22.
2001: Michael W Martin; A W Scott; D E Johnston; S Griffin; Robert R Luedtke
Typical antipsychotics exhibit inverse agonist activity at rat dopamine D1-like receptors expressed in Sf9 cells.
European journal of pharmacology 2001;420(2-3):73-82.
2001: Yunsheng Huang; Robert R Luedtke; Rebekah A Freeman; Li Wu; Robert H Mach
Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.
Journal of medicinal chemistry 2001;44(11):1815-26.
2000: Robert R Luedtke; Rebekah A Freeman; V A Boundy; Michael W Martin; Yunsheng Huang; Robert H Mach
Characterization of (125)I-IABN, a novel azabicyclononane benzamide selective for D2-like dopamine receptors.
Synapse (New York, N.Y.) 2000;38(4):438-49.
1999: Robert R Luedtke; S A Griffin; S S Conroy; X Jin; A Pinto; S R Sesack
Immunoblot and immunohistochemical comparison of murine monoclonal antibodies specific for the rat D1a and D1b dopamine receptor subtypes.
Journal of neuroimmunology 1999;101(2):170-87.
1999: Michael A Nader; KL Green; Robert R Luedtke; Robert H Mach
The effects of benzamide analogues on cocaine self-administration in rhesus monkeys.
Psychopharmacology 1999;147(2):143-52.