Reinhard Lührmann

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Pena Vladimir; Jovin Sina Mozaffari; Fabrizio Patrizia; Orlowski Jerzy; Bujnicki Janusz M; Lührmann Reinhard; Wahl Markus C
Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase.
Wahl Markus C; Will Cindy L; Lührmann Reinhard
The spliceosome: design principles of a dynamic RNP machine.
Lührmann Reinhard; Stark Holger
Structural mapping of spliceosomes by electron microscopy.

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All Publications

2009: Pena Vladimir; Jovin Sina Mozaffari; Fabrizio Patrizia; Orlowski Jerzy; Bujnicki Janusz M; Lührmann Reinhard; Wahl Markus C
Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase.
Molecular cell 2009;35(4):454-66.
2009: Wahl Markus C; Will Cindy L; Lührmann Reinhard
The spliceosome: design principles of a dynamic RNP machine.
Cell 2009;136(4):701-18.
2009: Lührmann Reinhard; Stark Holger
Structural mapping of spliceosomes by electron microscopy.
Current opinion in structural biology 2009;19(1):96-102.
2009: Trowitzsch Simon; Weber Gert; Lührmann Reinhard; Wahl Markus C
Crystal structure of the Pml1p subunit of the yeast precursor mRNA retention and splicing complex.
Journal of molecular biology 2009;385(2):531-41.
2008: Yu Yang; Maroney Patricia A; Denker John A; Zhang Xiang H-F; Dybkov Olexandr; Lührmann Reinhard; Jankowsky Eckhard; Chasin Lawrence A; Nilsen Timothy W
Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition.
Cell 2008;135(7):1224-36.
2008: Karaduman Ramazan; Dube Prakash; Stark Holger; Fabrizio Patrizia; Kastner Berthold; Lührmann Reinhard
Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy.
RNA (New York, N.Y.) 2008;14(12):2528-37.
2008: Häcker Irina; Sander Bjoern; Golas Monika M; Wolf Elmar; Karagöz Elif; Kastner Berthold; Stark Holger; Fabrizio Patrizia; Lührmann Reinhard
Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy.
Nature structural & molecular biology 2008;15(11):1206-12.
2008: Pena Vladimir; Rozov Alexey; Fabrizio Patrizia; Lührmann Reinhard; Wahl Markus C
Structure and function of an RNase H domain at the heart of the spliceosome.
The EMBO journal 2008;27(21):2929-40.
2008: Trowitzsch Simon; Weber Gert; Lührmann Reinhard; Wahl Markus C
An unusual RNA recognition motif acts as a scaffold for multiple proteins in the pre-mRNA retention and splicing complex.
The Journal of biological chemistry 2008;283(47):32317-27.
2008: Licht Konstantin; Medenbach Jan; Lührmann Reinhard; Kambach Christian; Bindereif Albrecht
3'-cyclic phosphorylation of U6 snRNA leads to recruitment of recycling factor p110 through LSm proteins.
RNA (New York, N.Y.) 2008;14(8):1532-8.
2008: Pessa Heli K J; Will Cindy L; Meng Xiaojuan; Schneider Claudia; Watkins Nicholas J; Perälä Nina; Nymark Mariann; Turunen Janne J; Lührmann Reinhard; Frilander Mikko J
Minor spliceosome components are predominantly localized in the nucleus.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8655-60.
2008: Mathew Rebecca; Hartmuth Klaus; Möhlmann Sina; Urlaub Henning; Ficner Ralf; Lührmann Reinhard
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.
Nature structural & molecular biology 2008;15(5):435-43.
2008: Turunen Janne J; Will Cindy L; Grote Michael; Lührmann Reinhard; Frilander Mikko J
The U11-48K protein contacts the 5' splice site of U12-type introns and the U11-59K protein.
Molecular and cellular biology 2008;28(10):3548-60.
2008: Bessonov Sergey; Anokhina Maria; Will Cindy L; Urlaub Henning; Lührmann Reinhard
Isolation of an active step I spliceosome and composition of its RNP core.
Nature 2008;452(7189):846-50.
2008: Kastner Berthold; Fischer Niels; Golas Monika Mariola; Sander Bjoern; Dube Prakash; Boehringer Daniel; Hartmuth Klaus; Deckert Jochen; Hauer Florian; Wolf Elmar; Uchtenhagen Hannes; Urlaub Henning; Herzog Franz; Peters Jan Michael; Poerschke Dietmar; Lührmann Reinhard; Stark Holger
GraFix: sample preparation for single-particle electron cryomicroscopy.
Nature methods 2008;5(1):53-5.
2008: Urlaub Henning; Kühn-Hölsken Eva; Lührmann Reinhard
Analyzing RNA-protein crosslinking sites in unlabeled ribonucleoprotein complexes by mass spectrometry.
Methods in molecular biology (Clifton, N.J.) 2008;488():221-45.
2007: Watkins Nicholas J; Lemm Ira; Lührmann Reinhard
Involvement of nuclear import and export factors in U8 box C/D snoRNP biogenesis.
Molecular and cellular biology 2007;27(20):7018-27.
2007: Nielsen Tine K; Liu Sunbin; Lührmann Reinhard; Ficner Ralf
Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2).
Journal of molecular biology 2007;369(4):902-8.
2007: Liu Sunbin; Li Ping; Dybkov Olexandr; Nottrott Stephanie; Hartmuth Klaus; Lührmann Reinhard; Carlomagno Teresa; Wahl Markus C
Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.
Science (New York, N.Y.) 2007;316(5821):115-20.
2007: Behzadnia Nastaran; Golas Monika M; Hartmuth Klaus; Sander Bjoern; Kastner Berthold; Deckert Jochen; Dube Prakash; Will Cindy L; Urlaub Henning; Stark Holger; Lührmann Reinhard
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.
The EMBO journal 2007;26(6):1737-48.
2007: Dönmez Gizem; Hartmuth Klaus; Kastner Berthold; Will Cindy L; Lührmann Reinhard
The 5' end of U2 snRNA is in close proximity to U1 and functional sites of the pre-mRNA in early spliceosomal complexes.
Molecular cell 2007;25(3):399-411.
2007: Kühn-Hölsken Eva; Dybkov Olexandr; Sander Björn; Lührmann Reinhard; Urlaub Henning
Improved identification of enriched peptide RNA cross-links from ribonucleoprotein particles (RNPs) by mass spectrometry.
Nucleic acids research 2007;35(15):e95.
2006: Sander Bjoern; Golas Monika M; Makarov Evgeny M; Brahms Hero; Kastner Berthold; Lührmann Reinhard; Stark Holger
Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy.
Molecular cell 2006;24(2):267-78.
2006: Behzadnia Nastaran; Hartmuth Klaus; Will Cindy L; Lührmann Reinhard
Functional spliceosomal A complexes can be assembled in vitro in the absence of a penta-snRNP.
RNA (New York, N.Y.) 2006;12(9):1738-46.
2006: Schultz Annemarie; Nottrott Stephanie; Hartmuth Klaus; Lührmann Reinhard
RNA structural requirements for the association of the spliceosomal hPrp31 protein with the U4 and U4atac small nuclear ribonucleoproteins.
The Journal of biological chemistry 2006;281(38):28278-86.
2006: Donnert Gerald; Keller Jan; Medda Rebecca; Andrei M Alexandra; Rizzoli Silvio O; Lührmann Reinhard; Jahn Reinhard; Eggeling Christian; Hell Stefan W
Macromolecular-scale resolution in biological fluorescence microscopy.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11440-5.
2006: Trippe Ralf; Guschina Elena; Hossbach Markus; Urlaub Henning; Lührmann Reinhard; Benecke Bernd-Joachim
Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase.
RNA (New York, N.Y.) 2006;12(8):1494-504.
2006: Deckert Jochen; Hartmuth Klaus; Boehringer Daniel; Behzadnia Nastaran; Will Cindy L; Kastner Berthold; Stark Holger; Urlaub Henning; Lührmann Reinhard
Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.
Molecular and cellular biology 2006;26(14):5528-43.
2006: Schultz Annemarie; Nottrott Stephanie; Watkins Nicholas James; Lührmann Reinhard
Protein-protein and protein-RNA contacts both contribute to the 15.5K-mediated assembly of the U4/U6 snRNP and the box C/D snoRNPs.
Molecular and cellular biology 2006;26(13):5146-54.
2006: Liu Sunbin; Rauhut Reinhard; Vornlocher Hans-Peter; Lührmann Reinhard
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.
RNA (New York, N.Y.) 2006;12(7):1418-30.
2006: Lemm Ira; Girard Cyrille; Kuhn Andreas N; Watkins Nicholas J; Schneider Marc; Bordonné Rémy; Lührmann Reinhard
Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies.
Molecular biology of the cell 2006;17(7):3221-31.
2006: Rhode Britta M; Hartmuth Klaus; Westhof Eric; Lührmann Reinhard
Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomes.
The EMBO journal 2006;25(11):2475-86.
2006: Bowers Heath A; Maroney Patricia A; Fairman Margaret E; Kastner Berthold; Lührmann Reinhard; Nilsen Timothy W; Jankowsky Eckhard
Discriminatory RNP remodeling by the DEAD-box protein DED1.
RNA (New York, N.Y.) 2006;12(5):903-12.
2006: Dybkov Olexandr; Will Cindy L; Deckert Jochen; Behzadnia Nastaran; Hartmuth Klaus; Lührmann Reinhard
U2 snRNA-protein contacts in purified human 17S U2 snRNPs and in spliceosomal A and B complexes.
Molecular and cellular biology 2006;26(7):2803-16.
2006: Spadaccini Roberta; Reidt Ulrich; Dybkov Olexandr; Will Cindy; Frank Ronald; Stier Gunter; Corsini Lorenzo; Wahl Markus C; Lührmann Reinhard; Sattler Michael
Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing.
RNA (New York, N.Y.) 2006;12(3):410-25.
2006: Karaduman Ramazan; Fabrizio Patrizia; Hartmuth Klaus; Urlaub Henning; Lührmann Reinhard
RNA structure and RNA-protein interactions in purified yeast U6 snRNPs.
Journal of molecular biology 2006;356(5):1248-62.
2006: Stark Holger; Lührmann Reinhard
Cryo-electron microscopy of spliceosomal components.
Annual review of biophysics and biomolecular structure 2006;35():435-57.
2005: Kühn-Hölsken Eva; Lenz Christof; Sander Björn; Lührmann Reinhard; Urlaub Henning
Complete MALDI-ToF MS analysis of cross-linked peptide-RNA oligonucleotides derived from nonlabeled UV-irradiated ribonucleoprotein particles.
RNA (New York, N.Y.) 2005;11(12):1915-30.
2005: Wozniak Anna K; Nottrott Stephanie; Kühn-Hölsken Eva; Schröder Gunnar F; Grubmüller Helmut; Lührmann Reinhard; Seidel Claus A M; Oesterhelt Filipp
Detecting protein-induced folding of the U4 snRNA kink-turn by single-molecule multiparameter FRET measurements.
RNA (New York, N.Y.) 2005;11(10):1545-54.
2005: Benecke Heike; Lührmann Reinhard; Will Cindy L
The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein.
The EMBO journal 2005;24(17):3057-69.
2005: Will Cindy L; Lührmann Reinhard
Splicing of a rare class of introns by the U12-dependent spliceosome.
Biological chemistry 2005;386(8):713-24.
2005: Strasser Anja; Dickmanns Achim; Lührmann Reinhard; Ficner Ralf
Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1.
The EMBO journal 2005;24(13):2235-43.
2005: Andrei Maria Alexandra; Ingelfinger Dierk; Heintzmann Rainer; Achsel Tilmann; Rivera-Pomar Rolando; Lührmann Reinhard
A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies.
RNA (New York, N.Y.) 2005;11(5):717-27.
2005: Laggerbauer Bernhard; Liu Sunbin; Makarov Evgeny; Vornlocher Hans-Peter; Makarova Olga; Ingelfinger Dierk; Achsel Tilmann; Lührmann Reinhard
The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.
RNA (New York, N.Y.) 2005;11(5):598-608.
2005: Golas Monika M; Sander Bjoern; Will Cindy L; Lührmann Reinhard; Stark Holger
Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy.
Molecular cell 2005;17(6):869-83.
2004: Watkins Nicholas J; Lemm Ira; Ingelfinger Dierk; Schneider Claudia; Hossbach Markus; Urlaub Henning; Lührmann Reinhard
Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex.
Molecular cell 2004;16(5):789-98.
2004: Dönmez Gizem; Hartmuth Klaus; Lührmann Reinhard
Modified nucleotides at the 5' end of human U2 snRNA are required for spliceosomal E-complex formation.
RNA (New York, N.Y.) 2004;10(12):1925-33.
2004: Narayanan Usha; Achsel Tilmann; Lührmann Reinhard; Matera A Gregory
Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein.
Molecular cell 2004;16(2):223-34.
2004: Strasser Anja; Dickmanns Achim; Schmidt Ute; Penka Elke; Urlaub Henning; Sekine Mitsuo; Lührmann Reinhard; Ficner Ralf
Purification, crystallization and preliminary crystallographic data of the m3G cap-binding domain of human snRNP import factor snurportin 1.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 9):1628-31.
2004: Schaffert Nina; Hossbach Markus; Heintzmann Rainer; Achsel Tilmann; Lührmann Reinhard
RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies.
The EMBO journal 2004;23(15):3000-9.
2004: Schneider Claudia; Will Cindy L; Brosius Jürgen; Frilander Mikko J; Lührmann Reinhard
Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9584-9.
2004: Makarova Olga V; Makarov Evgeny M; Urlaub Henning; Will Cindy L; Gentzel Marc; Wilm Matthias; Lührmann Reinhard
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing.
The EMBO journal 2004;23(12):2381-91.
2004: Will Cindy L; Schneider Claudia; Hossbach Markus; Urlaub Henning; Rauhut Reinhard; Elbashir Sayda; Tuschl Thomas; Lührmann Reinhard
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
RNA (New York, N.Y.) 2004;10(6):929-41.
2004: Boehringer Daniel; Makarov Evgeny M; Sander Bjoern; Makarova Olga V; Kastner Berthold; Lührmann Reinhard; Stark Holger
Three-dimensional structure of a pre-catalytic human spliceosomal complex B.
Nature structural & molecular biology 2004;11(5):463-8.
2004: Hartmuth Klaus; Vornlocher Hans-Peter; Lührmann Reinhard
Tobramycin affinity tag purification of spliceosomes.
Methods in molecular biology (Clifton, N.J.) 2004;257():47-64.
2003: Ingelfinger Dierk; Göthel Sven F; Marahiel Mohamed A; Reidt Ulrich; Ficner Ralf; Lührmann Reinhard; Achsel Tilmann
Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH.
Nucleic acids research 2003;31(16):4791-6.
2003: Reidt Ulrich; Wahl Markus C; Fasshauer Dirk; Horowitz David S; Lührmann Reinhard; Ficner Ralf
Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide.
Journal of molecular biology 2003;331(1):45-56.
2003: Golas Monika M; Sander Bjoern; Will Cindy L; Lührmann Reinhard; Stark Holger
Molecular architecture of the multiprotein splicing factor SF3b.
Science (New York, N.Y.) 2003;300(5621):980-4.
2002: Ingelfinger Dierk; Arndt-Jovin Donna J; Lührmann Reinhard; Achsel Tilmann
The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.
RNA (New York, N.Y.) 2002;8(12):1489-501.
2002: Hartmuth Klaus; Urlaub Henning; Vornlocher Hans-Peter; Will Cindy L; Gentzel Marc; Wilm Matthias; Lührmann Reinhard
Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16719-24.
2002: Watkins Nicholas J; Dickmanns Achim; Lührmann Reinhard
Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP.
Molecular and cellular biology 2002;22(23):8342-52.
2002: Makarov Evgeny M; Makarova Olga V; Urlaub Henning; Gentzel Marc; Will Cindy L; Wilm Matthias; Lührmann Reinhard
Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.
Science (New York, N.Y.) 2002;298(5601):2205-8.
2002: Nottrott Stephanie; Urlaub Henning; Lührmann Reinhard
Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins.
The EMBO journal 2002;21(20):5527-38.
2002: Will Cindy L; Urlaub Henning; Achsel Tilmann; Gentzel Marc; Wilm Matthias; Lührmann Reinhard
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.
The EMBO journal 2002;21(18):4978-88.
2002: Martinez Javier; Patkaniowska Agnieszka; Urlaub Henning; Lührmann Reinhard; Tuschl Thomas
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.
Cell 2002;110(5):563-74.
2002: Bartels Cornelia; Klatt Christine; Lührmann Reinhard; Fabrizio Patrizia
The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome.
EMBO reports 2002;3(9):875-80.
2002: Schneider Claudia; Will Cindy L; Makarova Olga V; Makarov Evgeny M; Lührmann Reinhard
Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions.
Molecular and cellular biology 2002;22(10):3219-29.
2002: Mougin Annie; Gottschalk Alexander; Fabrizio Patrizia; Lührmann Reinhard; Branlant Christiane
Direct probing of RNA structure and RNA-protein interactions in purified HeLa cell's and yeast spliceosomal U4/U6.U5 tri-snRNP particles.
Journal of molecular biology 2002;317(5):631-49.
2002: Makarova Olga V; Makarov Evgeny M; Liu Sunbin; Vornlocher Hans-Peter; Lührmann Reinhard
Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing.
The EMBO journal 2002;21(5):1148-57.
2002: Urlaub Henning; Hartmuth Klaus; Lührmann Reinhard
A two-tracked approach to analyze RNA-protein crosslinking sites in native, nonlabeled small nuclear ribonucleoprotein particles.
Methods (San Diego, Calif.) 2002;26(2):170-81.
2002: Huber Jochen; Dickmanns Achim; Lührmann Reinhard
The importin-beta binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro.
The Journal of cell biology 2002;156(3):467-79.
2001: Gottschalk A; Kastner B; Lührmann R; Fabrizio P
The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p.
RNA (New York, N.Y.) 2001;7(11):1554-65.
2001: Brahms H; Meheus L; de Brabandere V; Fischer U; Lührmann R
Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein.
RNA (New York, N.Y.) 2001;7(11):1531-42.
2001: Will C L; Schneider C; MacMillan A M; Katopodis N F; Neubauer G; Wilm M; Lührmann R; Query C C
A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.
The EMBO journal 2001;20(16):4536-46.
2001: Will C L; Lührmann R
Spliceosomal UsnRNP biogenesis, structure and function.
Current opinion in cell biology 2001;13(3):290-301.
2001: Makarova O V; Makarov E M; Lührmann R
The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes.
The EMBO journal 2001;20(10):2553-63.
2001: Gottschalk A; Bartels C; Neubauer G; Lührmann R; Fabrizio P
A novel yeast U2 snRNP protein, Snu17p, is required for the first catalytic step of splicing and for progression of spliceosome assembly.
Molecular and cellular biology 2001;21(9):3037-46.
2001: Achsel T; Stark H; Lührmann R
The Sm domain is an ancient RNA-binding motif with oligo(U) specificity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3685-9.
2001: Will C L; Lührmann R
Molecular biology. RNP remodeling with DExH/D boxes.
Science (New York, N.Y.) 2001;291(5510):1916-7.
2001: Urlaub H; Raker V A; Kostka S; Lührmann R
Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.
The EMBO journal 2001;20(1-2):187-96.
2001: Stark H; Dube P; Lührmann R; Kastner B
Arrangement of RNA and proteins in the spliceosomal U1 small nuclear ribonucleoprotein particle.
Nature 2001;409(6819):539-42.
2000: Vidovic I; Nottrott S; Hartmuth K; Lührmann R; Ficner R
Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment.
Molecular cell 2000;6(6):1331-42.
2000: Urlaub H; Hartmuth K; Kostka S; Grelle G; Lührmann R
A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs.
The Journal of biological chemistry 2000;275(52):41458-68.
2000: Watkins N J; Ségault V; Charpentier B; Nottrott S; Fabrizio P; Bachi A; Wilm M; Rosbash M; Branlant C; Lührmann R
A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP.
Cell 2000;103(3):457-66.
2000: Brahms H; Raymackers J; Union A; de Keyser F; Meheus L; Lührmann R
The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies.
The Journal of biological chemistry 2000;275(22):17122-9.
2000: Makarov E M; Makarova O V; Achsel T; Lührmann R
The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions.
Journal of molecular biology 2000;298(4):567-75.
2000: Reidt U; Reuter K; Achsel T; Ingelfinger D; Lührmann R; Ficner R
Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin.
The Journal of biological chemistry 2000;275(11):7439-42.
1999: Reuter K; Nottrott S; Fabrizio P; Lührmann R; Ficner R
Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein.
Journal of molecular biology 1999;294(2):515-25.
1999: Nottrott S; Hartmuth K; Fabrizio P; Urlaub H; Vidovic I; Ficner R; Lührmann R
Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA.
The EMBO journal 1999;18(21):6119-33.
1999: Fischer U; Pollard V W; Lührmann R; Teufel M; Michael M W; Dreyfuss G; Malim M H
Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.
Nucleic acids research 1999;27(21):4128-34.
1999: Achsel T; Brahms H; Kastner B; Bachi A; Wilm M; Lührmann R
A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.
The EMBO journal 1999;18(20):5789-802.
1999: Raker V A; Hartmuth K; Kastner B; Lührmann R
Spliceosomal U snRNP core assembly: Sm proteins assemble onto an Sm site RNA nonanucleotide in a specific and thermodynamically stable manner.
Molecular and cellular biology 1999;19(10):6554-65.
1999: Gottschalk A; Neubauer G; Banroques J; Mann M; Lührmann R; Fabrizio P
Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP.
The EMBO journal 1999;18(16):4535-48.
1999: Will C L; Schneider C; Reed R; Lührmann R
Identification of both shared and distinct proteins in the major and minor spliceosomes.
Science (New York, N.Y.) 1999;284(5422):2003-5.
1999: Ségault V; Will C L; Polycarpou-Schwarz M; Mattaj I W; Branlant C; Lührmann R
Conserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts.
Molecular and cellular biology 1999;19(4):2782-90.
1999: Hartmuth K; Raker V A; Huber J; Branlant C; Lührmann R
An unusual chemical reactivity of Sm site adenosines strongly correlates with proper assembly of core U snRNP particles.
Journal of molecular biology 1999;285(1):133-47.
1999: Kastner B; Lührmann R
Purification of U small nuclear ribonucleoprotein particles.
Methods in molecular biology (Clifton, N.J.) 1999;118():289-98.
1998: Watkins N J; Gottschalk A; Neubauer G; Kastner B; Fabrizio P; Mann M; Lührmann R
Cbf5p, a potential pseudouridine synthase, and Nhp2p, a putative RNA-binding protein, are present together with Gar1p in all H BOX/ACA-motif snoRNPs and constitute a common bipartite structure.
RNA (New York, N.Y.) 1998;4(12):1549-68.
1998: Achsel T; Ahrens K; Brahms H; Teigelkamp S; Lührmann R
The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein.
Molecular and cellular biology 1998;18(11):6756-66.
1998: Ortlepp D; Laggerbauer B; Müllner S; Achsel T; Kirschbaum B; Lührmann R
The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis.
RNA (New York, N.Y.) 1998;4(8):1007-18.
1998: Huber J; Cronshagen U; Kadokura M; Marshallsay C; Wada T; Sekine M; Lührmann R
Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure.
The EMBO journal 1998;17(14):4114-26.
1998: Gottschalk A; Tang J; Puig O; Salgado J; Neubauer G; Colot H V; Mann M; Séraphin B; Rosbash M; Lührmann R; Fabrizio P
A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins.
RNA (New York, N.Y.) 1998;4(4):374-93.
1998: Laggerbauer B; Achsel T; Lührmann R
The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4188-92.
1998: Teigelkamp S; Achsel T; Mundt C; Göthel S F; Cronshagen U; Lane W S; Marahiel M; Lührmann R
The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins.
RNA (New York, N.Y.) 1998;4(2):127-41.
1997: Teigelkamp S; Mundt C; Achsel T; Will C L; Lührmann R
The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p.
RNA (New York, N.Y.) 1997;3(11):1313-26.
1997: Méreau A; Fournier R; Grégoire A; Mougin A; Fabrizio P; Lührmann R; Branlant C
An in vivo and in vitro structure-function analysis of the Saccharomyces cerevisiae U3A snoRNP: protein-RNA contacts and base-pair interaction with the pre-ribosomal RNA.
Journal of molecular biology 1997;273(3):552-71.
1997: Lauber J; Plessel G; Prehn S; Will C L; Fabrizio P; Gröning K; Lane W S; Lührmann R
The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p.
RNA (New York, N.Y.) 1997;3(8):926-41.
1997: Fabrizio P; Laggerbauer B; Lauber J; Lane W S; Lührmann R
An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.
The EMBO journal 1997;16(13):4092-106.
1997: Will C L; Lührmann R
Protein functions in pre-mRNA splicing.
Current opinion in cell biology 1997;9(3):320-8.
1997: Brahms H; Raker V A; van Venrooij W J; Lührmann R
A major, novel systemic lupus erythematosus autoantibody class recognizes the E, F, and G Sm snRNP proteins as an E-F-G complex but not in their denatured states.
Arthritis and rheumatism 1997;40(4):672-82.
1997: Fetzer S; Lauber J; Will C L; Lührmann R
The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase.
RNA (New York, N.Y.) 1997;3(4):344-55.
1997: Plessel G; Lührmann R; Kastner B
Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core.
Journal of molecular biology 1997;265(2):87-94.
1997: Neubauer G; Gottschalk A; Fabrizio P; Séraphin B; Lührmann R; Mann M
Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):385-90.
1996: Hackl W; Lührmann R
Molecular cloning and subcellular localisation of the snRNP-associated protein 69KD, a structural homologue of the proto-oncoproteins TLS and EWS with RNA and DNA-binding properties.
Journal of molecular biology 1996;264(5):843-51.
1996: Will C L; Rümpler S; Klein Gunnewiek J; van Venrooij W J; Lührmann R
In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes.
Nucleic acids research 1996;24(23):4614-23.
1996: Dickmanns A; Bischoff F R; Marshallsay C; Lührmann R; Ponstingl H; Fanning E
The thermolability of nuclear protein import in tsBN2 cells is suppressed by microinjected Ran-GTP or Ran-GDP, but not by RanQ69L or RanT24N.
Journal of cell science 1996;109 ( Pt 6)():1449-57.
1996: Marshallsay C; Dickmanns A; Bischoff F R; Ponstingl H; Fanning E; Lührmann R
In vitro and in vivo evidence that protein and U1 snRNP nuclear import in somatic cells differ in their requirement for GTP-hydrolysis, Ran/TC4 and RCC1.
Nucleic acids research 1996;24(10):1829-36.
1996: Raker V A; Plessel G; Lührmann R
The snRNP core assembly pathway: identification of stable core protein heteromeric complexes and an snRNP subcore particle in vitro.
The EMBO journal 1996;15(9):2256-69.
1996: Fridell R A; Fischer U; Lührmann R; Meyer B E; Meinkoth J L; Malim M H; Cullen B R
Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2936-40.
1996: Laggerbauer B; Lauber J; Lührmann R
Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs.
Nucleic acids research 1996;24(5):868-75.
1996: Kubicka-Muranyi M; Kremer J; Rottmann N; Lübben B; Albers R; Bloksma N; Lührmann R; Gleichmann E
Murine systemic autoimmune disease induced by mercuric chloride: T helper cells reacting to self proteins.
International archives of allergy and immunology 1996;109(1):11-20.
1995: Kubicka-Muranyi M; Griem P; Lübben B; Rottmann N; Lührmann R; Gleichmann E
Mercuric-chloride-induced autoimmunity in mice involves up-regulated presentation by spleen cells of altered and unaltered nucleolar self antigen.
International archives of allergy and immunology 1995;108(1):1-10.
1995: Jamison S F; Pasman Z; Wang J; Will C; Lührmann R; Manley J L; Garcia-Blanco M A
U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.
Nucleic acids research 1995;23(16):3260-7.
1995: Ségault V; Will C L; Sproat B S; Lührmann R
In vitro reconstitution of mammalian U2 and U5 snRNPs active in splicing: Sm proteins are functionally interchangeable and are essential for the formation of functional U2 and U5 snRNPs.
The EMBO journal 1995;14(16):4010-21.
1995: Fischer U; Huber J; Boelens W C; Mattaj I W; Lührmann R
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs.
Cell 1995;82(3):475-83.
1995: Lübben B; Fabrizio P; Kastner B; Lührmann R
Isolation and characterization of the small nucleolar ribonucleoprotein particle snR30 from Saccharomyces cerevisiae.
The Journal of biological chemistry 1995;270(19):11549-54.
1995: Hermann H; Fabrizio P; Raker V A; Foulaki K; Hornig H; Brahms H; Lührmann R
snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions.
The EMBO journal 1995;14(9):2076-88.
1994: Lehmeier T; Raker V; Hermann H; Lührmann R
cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12317-21.
1994: Fischer U; Meyer S; Teufel M; Heckel C; Lührmann R; Rautmann G
Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA.
The EMBO journal 1994;13(17):4105-12.
1994: Plessel G; Fischer U; Lührmann R
m3G cap hypermethylation of U1 small nuclear ribonucleoprotein (snRNP) in vitro: evidence that the U1 small nuclear RNA-(guanosine-N2)-methyltransferase is a non-snRNP cytoplasmic protein that requires a binding site on the Sm core domain.
Molecular and cellular biology 1994;14(6):4160-72.
1994: Fischer U; Heinrich J; van Zee K; Fanning E; Lührmann R
Nuclear transport of U1 snRNP in somatic cells: differences in signal requirement compared with Xenopus laevis oocytes.
The Journal of cell biology 1994;125(5):971-80.
1994: Fabrizio P; Esser S; Kastner B; Lührmann R
Isolation of S. cerevisiae snRNPs: comparison of U1 and U4/U6.U5 to their human counterparts.
Science (New York, N.Y.) 1994;264(5156):261-5.
1994: Kohtz J D; Jamison S F; Will C L; Zuo P; Lührmann R; Garcia-Blanco M A; Manley J L
Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors.
Nature 1994;368(6467):119-24.
1994: Hackl W; Fischer U; Lührmann R
A 69-kD protein that associates reversibly with the Sm core domain of several spliceosomal snRNP species.
The Journal of cell biology 1994;124(3):261-72.
1994: Marshallsay C; Lührmann R
In vitro nuclear import of snRNPs: cytosolic factors mediate m3G-cap dependence of U1 and U2 snRNP transport.
The EMBO journal 1994;13(1):222-31.
1994: Lübben B; Rottmann N; Kubicka-Muranyi M; Gleichmann E; Lührmann R
The specificity of disease-associated anti-fibrillarin autoantibodies compared with that of HgCl2-induced autoantibodies.
Molecular biology reports 1994;20(2):63-73.
1993: Lübben B; Marshallsay C; Rottmann N; Lührmann R
Isolation of U3 snoRNP from CHO cells: a novel 55 kDa protein binds to the central part of U3 snoRNA.
Nucleic acids research 1993;21(23):5377-85.
1993: Behrens S E; Galisson F; Legrain P; Lührmann R
Evidence that the 60-kDa protein of 17S U2 small nuclear ribonucleoprotein is immunologically and functionally related to the yeast PRP9 splicing factor and is required for the efficient formation of prespliceosomes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8229-33.
1993: Will C L; Behrens S E; Lührmann R
Protein composition of mammalian spliceosomal snRNPs.
Molecular biology reports 1993;18(2):121-6.
1993: Blencowe B J; Carmo-Fonseca M; Behrens S E; Lührmann R; Lamond A I
Interaction of the human autoantigen p150 with splicing snRNPs.
Journal of cell science 1993;105 ( Pt 3)():685-97.
1993: Woppmann A; Will C L; Kornstädt U; Zuo P; Manley J L; Lührmann R
Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.
Nucleic acids research 1993;21(12):2815-22.
1993: van Zee K; Dickmanns A; Fischer U; Lührmann R; Fanning E
A cytoplasmically anchored nuclear protein interferes specifically with the import of nuclear proteins but not U1 snRNA.
The Journal of cell biology 1993;121(2):229-40.
1993: Fischer U; Sumpter V; Sekine M; Satoh T; Lührmann R
Nucleo-cytoplasmic transport of U snRNPs: definition of a nuclear location signal in the Sm core domain that binds a transport receptor independently of the m3G cap.
The EMBO journal 1993;12(2):573-83.
1993: Behrens S E; Tyc K; Kastner B; Reichelt J; Lührmann R
Small nuclear ribonucleoprotein (RNP) U2 contains numerous additional proteins and has a bipartite RNP structure under splicing conditions.
Molecular and cellular biology 1993;13(1):307-19.
1992: Sumpter V; Kahrs A; Fischer U; Kornstädt U; Lührmann R
In vitro reconstitution of U1 and U2 snRNPs from isolated proteins and snRNA.
Molecular biology reports 1992;16(4):229-40.
1992: Heinrichs V; Hackl W; Lührmann R
Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro.
Journal of molecular biology 1992;227(1):15-28.
1992: Kastner B; Kornstädt U; Bach M; Lührmann R
Structure of the small nuclear RNP particle U1: identification of the two structural protuberances with RNP-antigens A and 70K.
The Journal of cell biology 1992;116(4):839-49.
1991: Behrens S E; Lührmann R
Immunoaffinity purification of a [U4/U6.U5] tri-snRNP from human cells.
Genes & development 1991;5(8):1439-52.
1991: Fischer U; Darzynkiewicz E; Tahara S M; Dathan N A; Lührmann R; Mattaj I W
Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport.
The Journal of cell biology 1991;113(4):705-14.
1991: Kastner B; Bach M; Lührmann R
Electron microscopy of U4/U6 snRNP reveals a Y-shaped U4 and U6 RNA containing domain protruding from the U4 core RNP.
The Journal of cell biology 1991;112(6):1065-72.
1991: Bach M; Lührmann R
Protein-RNA interactions in 20S U5 snRNPs.
Biochimica et biophysica acta 1991;1088(1):139-43.
1990: Lührmann R; Kastner B; Bach M
Structure of spliceosomal snRNPs and their role in pre-mRNA splicing.
Biochimica et biophysica acta 1990;1087(3):265-92.
1990: Lehmeier T; Foulaki K; Lührmann R
Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5.
Nucleic acids research 1990;18(22):6475-84.
1990: Tollervey D; Tessars G; Lührmann R
Immunoprecipitation distinguishes non-overlapping groups of snRNPs in Schizosaccharomyces pombe.
Nucleic acids research 1990;18(17):5207-12.
1990: Fischer U; Lührmann R
An essential signaling role for the m3G cap in the transport of U1 snRNP to the nucleus.
Science (New York, N.Y.) 1990;249(4970):786-90.
1990: Woppmann A; Patschinsky T; Bringmann P; Godt F; Lührmann R
Characterisation of human and murine snRNP proteins by two-dimensional gel electrophoresis and phosphopeptide analysis of U1-specific 70K protein variants.
Nucleic acids research 1990;18(15):4427-38.
1990: Kastner B; Bach M; Lührmann R
Electron microscopy of small nuclear ribonucleoprotein (snRNP) particles U2 and U5: evidence for a common structure-determining principle in the major U snRNP family.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1710-4.
1990: Bach M; Krol A; Lührmann R
Structure-probing of U1 snRNPs gradually depleted of the U1-specific proteins A, C and 70k. Evidence that A interacts differentially with developmentally regulated mouse U1 snRNA variants.
Nucleic acids research 1990;18(3):449-57.
1990: Behrens S E; Lührmann R
Immuno affinity purification and characterization of a stable U4/U5/U6 multip-snRNP complex from HeLa nuclear extracts.
Molecular biology reports 1990;14(2-3):195.
1990: Lührmann R
Functions of U-snRNPs.
Molecular biology reports 1990;14(2-3):183-92.
1990: Kastner B; Bach M; Lührmann R
Electron microscopy of snRNPs U2, U4/6 and U5: evidence for a common structure-determining principle in the major UsnRNP family.
Molecular biology reports 1990;14(2-3):171.
1990: Heinrichs V; Bach M; Lührmann R
U1-specific protein C is required for efficient complex formation of U1 snRNP with a 5' splice site.
Molecular biology reports 1990;14(2-3):165.
1990: Lehmeier T; Foulaki K; Lührmann R
Identification and characterization of novel Sm-autoantigens associated with the major snRNPs U1, U2, U4/U6 and U5.
Molecular biology reports 1990;14(2-3):175.

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