FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Ruth Lupu

Research Profile

Disorders

Chemicals & Drugs

Physiology

Anatomy

Genes & Molecular Sequences

Genes, erbB-2

Co-author Network

Publications

TOP 3
Alejandro Vazquez-Martin; Luciano Vellon; Octavio J Menendez; Cristina Oliveras-Ferraros; Bruna Corominas-Faja; Sílvia Cufi; Jorge Joven; Ruth Lupu; Javier A Menendez
The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.
Ruth Lupu; ramon colomer; Javier A Menéndez
An easy, rapid and objective mathematical method to identify fatty acid synthase (oncogenic antigen-519) modulators with potential anticancer value.
ramon colomer; Ruth Lupu; A Papadimitropoulou; L Vellón; Alejandro Vázquez-Martín; Joan Brunet; A Fernández-Gutiérrez; Antonio Segura-Carretero; Javier Abel Menéndez
Giacomo Castelvetro's salads. Anti-HER2 oncogene nutraceuticals since the 17th century?

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Ruth Lupu (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Alejandro Vazquez-Martin; Luciano Vellon; Octavio J Menendez; Cristina Oliveras-Ferraros; Bruna Corominas-Faja; Sílvia Cufi; Jorge Joven; Ruth Lupu; Javier A Menendez
The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.
Cell cycle (Georgetown, Tex.) 2013;12(2):207-18.
2008: Ruth Lupu; ramon colomer; Javier A Menéndez
An easy, rapid and objective mathematical method to identify fatty acid synthase (oncogenic antigen-519) modulators with potential anticancer value.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2008;10(4):219-26.
2008: ramon colomer; Ruth Lupu; A Papadimitropoulou; L Vellón; Alejandro Vázquez-Martín; Joan Brunet; A Fernández-Gutiérrez; Antonio Segura-Carretero; Javier Abel Menéndez
Giacomo Castelvetro's salads. Anti-HER2 oncogene nutraceuticals since the 17th century?
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2008;10(1):30-4.
2007: Luciano Vellon; Javier A Menendez; Hong Liu; Ruth Lupu
Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner.
Differentiation; research in biological diversity 2007;75(9):819-30.
2007: Javier A Menendez; Ruth Lupu
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.
Nature reviews. Cancer 2007;7(10):763-77.
2007: Javier A Menendez; Ruth Lupu
Targeting human epidermal growth factor receptor 2: it is time to kill kinase death human epidermal growth factor receptor 3.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(17):2496-8; author reply 2499.
2006: Javier A Menendez; Ruth Lupu
Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9).
Current pharmaceutical biotechnology 2006;7(6):495-502.
2006: Ruth Lupu; Javier A Menendez
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?
Current pharmaceutical biotechnology 2006;7(6):483-93.
2006: Javier A Menendez; Luciano Vellon; Ruth Lupu
DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes.
International journal of molecular medicine 2006;18(6):1081-7.
2006: Javier Abel Menéndez; Alejandro Vázquez-Martín; Santiago Ropero; ramon colomer; Ruth Lupu
HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anti-HER2 cocktail".
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2006;8(11):812-20.
2006: Luciano Vellon; Javier A Menendez; Ruth Lupu
A bidirectional "alpha(v)beta(3) integrin-ERK1/ERK2 MAPK" connection regulates the proliferation of breast cancer cells.
Molecular carcinogenesis 2006;45(10):795-804.
2006: Javier A Menendez; Adriana Papadimitropoulou; Luciano Vellon; Ruth Lupu
A genomic explanation connecting "Mediterranean diet", olive oil and cancer: oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory "PEA3 transcription factor-PEA3 DNA binding site" complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells.
European journal of cancer (Oxford, England : 1990) 2006;42(15):2425-32.
2006: Ruth Lupu; Javier A Menendez
Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?
Endocrinology 2006;147(9):4056-66.
2006: Javier A Menendez; Inderjit Mehmi; Ruth Lupu
Trastuzumab in combination with heregulin-activated Her-2 (erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(23):3735-46.
2006: Javier A Menendez; Ruth Lupu
Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells.
Current opinion in clinical nutrition and metabolic care 2006;9(4):346-57.
2006: Javier A Menendez; Luciano Vellon; Ruth Lupu
The antiobesity drug Orlistat induces cytotoxic effects, suppresses Her-2/neu (erbB-2) oncogene overexpression, and synergistically interacts with trastuzumab (Herceptin) in chemoresistant ovarian cancer cells.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2006;16(1):219-21.
2005: Javier A Menendez; Luciano Vellon; ramon colomer; Ruth Lupu
Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene.
Journal of the National Cancer Institute 2005;97(21):1611-5.
2005: Javier A Menendez; Luciano Vellon; Ruth Lupu
Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(8):1253-67.
2005: Javier A Menendez; Ruth Lupu; ramon colomer
Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer.
Drug news & perspectives 2005;18(6):375-85.
2005: Javier A Menendez; Ruth Lupu; ramon colomer
Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2005;14(3):263-70.
2005: Javier A Menendez; Bharvi Praful Oza; ramon colomer; Ruth Lupu
The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.
International journal of oncology 2005;26(6):1507-15.
2005: Luciano Vellon; Javier A Menendez; Ruth Lupu
AlphaVbeta3 integrin regulates heregulin (HRG)-induced cell proliferation and survival in breast cancer.
Oncogene 2005;24(23):3759-73.
2005: Javier A Menendez; Luciano Vellon; ramon colomer; Ruth Lupu
Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity.
International journal of cancer. Journal international du cancer 2005;115(1):19-35.
2005: Javier A Menendez; Luciano Vellon; Bharvi Praful Oza; Ruth Lupu
Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1alpha (HIF-1alpha)-related expression of vascular endothelial growth factor (VEGF) in cancer cells overexpressing her-2/neu oncogene.
Journal of cellular biochemistry 2005;94(5):857-63.
2005: Javier A Menendez; Luciano Vellon; Ruth Lupu
Orlistat: from antiobesity drug to anticancer agent in Her-2/neu (erbB-2)-overexpressing gastrointestinal tumors?
Experimental biology and medicine (Maywood, N.J.) 2005;230(3):151-4.
2005: Javier A Menendez; Inderjit Mehmi; Ruth Lupu
Heregulin-triggered Her-2/neu signaling enhances nuclear accumulation of p21WAF1/CIP1 and protects breast cancer cells from cisplatin-induced genotoxic damage.
International journal of oncology 2005;26(3):649-59.
2005: Javier A Menendez; Ruth Lupu; ramon colomer
Obesity, fatty acid synthase, and cancer: serendipity or forgotten causal linkage?
Molecular genetics and metabolism 2005;84(3):293-5.
2005: Javier A Menendez; Luciano Vellon; ramon colomer; Ruth Lupu
Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(3):359-71.
2005: Javier A Menendez; Luciano Vellon; Inderjit Mehmi; Poh K Teng; David W Griggs; Ruth Lupu
A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway.
Oncogene 2005;24(5):761-79.
2005: Javier A Menendez; Luciano Vellon; Ruth Lupu
Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells.
Medical hypotheses 2005;64(5):997-1001.
2005: Javier A Menendez; ramon colomer; Ruth Lupu
Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?
Medical hypotheses 2005;64(2):342-9.
2005: Javier A Menendez; ramon colomer; Ruth Lupu
Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis.
Medical hypotheses 2005;64(2):337-41.
2005: Javier A Menendez; Ruth Lupu
RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells.
International journal of molecular medicine 2005;15(1):33-40.
2005: Javier A Menendez; Josiah P Decker; Ruth Lupu
In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells.
Journal of cellular biochemistry 2005;94(1):1-4.
2004: Javier A Menendez; Ruth Lupu
Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: from anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells.
Archivum immunologiae et therapiae experimentalis 2004;52(6):414-26.
2004: Javier A Menendez; Santiago Ropero; Ruth Lupu; ramon colomer
Dietary fatty acids regulate the activation status of Her-2/neu (c-erbB-2) oncogene in breast cancer cells.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(11):1719-21.
2004: Javier A Menendez; Inderjit Mehmi; Vishal A Verma; Poh K Teng; Ruth Lupu
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.
Molecular carcinogenesis 2004;41(3):164-78.
2004: Javier A Menendez; ramon colomer; Ruth Lupu
Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells.
Oncology reports 2004;12(2):411-22.
2004: Javier A Menendez; Luciano Vellon; Inderjit Mehmi; Bharvi Praful Oza; Santiago Ropero; ramon colomer; Ruth Lupu
Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10715-20.
2004: Javier A Menendez; Bharvi Praful Oza; Ella Atlas; Vishal A Verma; Inderjit Mehmi; Ruth Lupu
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells.
Oncogene 2004;23(28):4945-58.
2004: Javier A Menendez; Santiago Ropero; Inderjit Mehmi; Ella Atlas; ramon colomer; Ruth Lupu
Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis.
International journal of oncology 2004;24(6):1369-83.
2004: Javier A Menendez; Santiago Ropero; Ruth Lupu; ramon colomer
Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: Relationship to lipid peroxidation and HER-2/neu expression.
Oncology reports 2004;11(6):1241-52.
2004: Javier A Menendez; ramon colomer; Ruth Lupu
Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells.
International journal of cancer. Journal international du cancer 2004;109(6):949-54.
2004: Javier A Menendez; Ruth Lupu; ramon colomer
Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER -2/ neu -overexpressing human breast cancer cells to docetaxel (taxotere).
Breast cancer research and treatment 2004;84(2):183-95.
2004: Javier A Menendez; Inderjit Mehmi; Ella Atlas; ramon colomer; Ruth Lupu
Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.
International journal of oncology 2004;24(3):591-608.
2003: Ruth Lupu; Inderjit Mehmi; Ella Atlas; Miaw-Sheue Tsai; Emily Pisha; Hellen Oketch-Rabah; Paiboon Nuntanakorn; Edward J Kennelly; Fredi Kronenberg
Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth.
International journal of oncology 2003;23(5):1407-12.
2003: J A Menéndez; Inderjit Mehmi; D W Griggs; Ruth Lupu
The angiogenic factor CYR61 in breast cancer: molecular pathology and therapeutic perspectives.
Endocrine-related cancer 2003;10(2):141-52.
2003: Ella Atlas; Kozystof Bojanowski; Inderjit Mehmi; Ruth Lupu
A deletion mutant of heregulin increases the sensitivity of breast cancer cells to chemotherapy without promoting tumorigenicity.
Oncogene 2003;22(22):3441-51.
2003: Miaw-Sheue Tsai; Lisa A Shamon-Taylor; Inderjit Mehmi; Careen K Tang; Ruth Lupu
Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer.
Oncogene 2003;22(5):761-8.
2003: Ella Atlas; Marina Cardillo; Inderjit Mehmi; Hengameh Zahedkargaran; Careen Tang; Ruth Lupu
Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo.
Molecular cancer research : MCR 2003;1(3):165-75.
2002: Miaw-Sheue Tsai; Daphne F Bogart; Jessica M Castañeda; Patricia Li; Ruth Lupu
Cyr61 promotes breast tumorigenesis and cancer progression.
Oncogene 2002;21(53):8178-85.
2002: Miaw-Sheue Tsai; Daphne F Bogart; Patricia Li; Inderjit Mehmi; Ruth Lupu
Expression and regulation of Cyr61 in human breast cancer cell lines.
Oncogene 2002;21(6):964-73.
2001: FK Guerra-Vladusic; EA Vladusic; Miaw-Sheue Tsai; Ruth Lupu
Signaling molecules implicated in heregulin induction of growth arrest and apoptosis.
Oncology reports 2001;8(6):1203-14.
2000: Miaw-Sheue Tsai; AE Hornby; J Lakins; Ruth Lupu
Expression and function of CYR61, an angiogenic factor, in breast cancer cell lines and tumor biopsies.
Cancer research 2000;60(20):5603-7.
2000: EA Vladusic; AE Hornby; FK Guerra-Vladusic; J Lakins; Ruth Lupu
Expression and regulation of estrogen receptor beta in human breast tumors and cell lines.
Oncology reports 2000;7(1):157-67.
1999: W M Liu; FK Guerra-Vladusic; Shinichi Kurakata; Ruth Lupu; Terumi Kohwi-Shigematsu
HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype.
Cancer research 1999;59(22):5695-703.
1999: FK Guerra-Vladusic; G Scott; V Weaver; EA Vladusic; Miaw-Sheue Tsai; C C Benz; Ruth Lupu
Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3.
International journal of oncology 1999;15(5):883-92.
1998: Fei Wang; Valerie M Weaver; Ole W Petersen; Carolyn A Larabell; S Dedhar; P Briand; Ruth Lupu; Mina J Bissell
Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14821-6.
1998: EA Vladusic; AE Hornby; FK Guerra-Vladusic; Ruth Lupu
Expression of estrogen receptor beta messenger RNA variant in breast cancer.
Cancer research 1998;58(2):210-4.