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Aldons Lusis

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Robert A Koeth; Ronald M Krauss; Bruce Levison; James D Lewis; Hongzhe Li; Lin Li; Aldons J Lusis; Elin Org; Brendan T Sheehy; Jonathan D Smith; W H Wilson Tang; Zeneng Wang; Manya Warrier; Gary D Wu; Yuping Wu; Earl B Britt; J Mark Brown; Jennifer A Buffa; Frederic D Bushman; Jun Chen; Joseph A DiDonato; Xiaoming Fu; Stanley L Hazen
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis.
Daphna Weissglas-Volkov; Prasad M V Linga Reddy; Laura Riba; Janet S Sinsheimer; Marja-Riitta Taskinen; Teresa Tusie-Luna; Carlos A Aguilar-Salinas; Olimpia Arellano-Campos; Rita M Cantor; Ivette Cruz-Bautista; Kerry A Deere; Lizeth Gomez-Munguia; Aldons J Lusis; Niina Matikainen; Linda Liliana Muñoz-Hernandez; Elina Nikkola; Maria Luisa Ordoñez-Sánchez; Päivi Pajukanta
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
Richard C Davis; Eleazar Eskin; Brian Bennett; Luz Orozco; Calvin Pan; Christoph D Rau; Atila Van Nas; Aldons J Lusis
Genome-wide association mapping of blood cell traits in mice.

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2013: Robert A Koeth; Ronald M Krauss; Bruce Levison; James D Lewis; Hongzhe Li; Lin Li; Aldons J Lusis; Elin Org; Brendan T Sheehy; Jonathan D Smith; W H Wilson Tang; Zeneng Wang; Manya Warrier; Gary D Wu; Yuping Wu; Earl B Britt; J Mark Brown; Jennifer A Buffa; Frederic D Bushman; Jun Chen; Joseph A DiDonato; Xiaoming Fu; Stanley L Hazen
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis.
Nature medicine 2013;19(5):576-85.
2013: Daphna Weissglas-Volkov; Prasad M V Linga Reddy; Laura Riba; Janet S Sinsheimer; Marja-Riitta Taskinen; Teresa Tusie-Luna; Carlos A Aguilar-Salinas; Olimpia Arellano-Campos; Rita M Cantor; Ivette Cruz-Bautista; Kerry A Deere; Lizeth Gomez-Munguia; Aldons J Lusis; Niina Matikainen; Linda Liliana Muñoz-Hernandez; Elina Nikkola; Maria Luisa Ordoñez-Sánchez; Päivi Pajukanta
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
Journal of medical genetics 2013;50(5):298-308.
2013: Richard C Davis; Eleazar Eskin; Brian Bennett; Luz Orozco; Calvin Pan; Christoph D Rau; Atila Van Nas; Aldons J Lusis
Genome-wide association mapping of blood cell traits in mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2013;24(3-4):105-18.
2013: Sandrine Lagarrigue; Frédéric Lecerf; Thomas A Drake; Eleazar Eskin; Anatole Ghazalpour; Raffi Hagopian; Yehudit Hasin; Farhad Hormozdiari; Lisa J Martin; Christoph Rau; Yu Xiao; Jun Yan; Aldons J Lusis
Limited RNA editing in exons of mouse liver and adipose.
Genetics 2013;193(4):1107-15.
2013: Tyler J Marquart; Judy Wu; Aldons J Lusis; Angel Baldan
Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(3):455-8.
2013: Daniel S Halperin; Aldons J Lusis; Calvin Pan; Peter Tontonoz
Vestigial-like 3 is an inhibitor of adipocyte differentiation.
Journal of lipid research 2013;54(2):473-81.
2013: Brian W Parks; Christoph D Rau; Luke K Ursell; Bradley Zinker; Margarete Mehrabian; Elizabeth Nam; Frode Norheim; Elin Org; Calvin Pan; Brian J Bennett; Lawrence W Castellani; Mete Civelek; Thomas A Drake; Christian Andre Drevon; Eleazar Eskin; Peter Gargalovic; Aiqing He; Simon T Hui; Mark Kirby; Todd Kirchgessner; Rob Knight; Emrah Kostem; Aldons J Lusis
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.
Cell metabolism 2013;17(1):141-52.
2013: Brian J Bennett; Rosanne Crooke; Peter A Edwards; Mark Graham; Jill Gregory; Stanley L Hazen; Richard Lee; Yonghong Meng; Diana M Shih; Zeneng Wang; Thomas Q de Aguiar Vallim; Hooman Allayee; Aldons J Lusis
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.
Cell metabolism 2013;17(1):49-60.
2013: Christoph D Rau; James Weiss; Nicholas Wisniewski; Brian Bennett; Luz D Orozco; Aldons J Lusis
Maximal information component analysis: a novel non-linear network analysis method.
Frontiers in genetics 2013;4():28.
2012: Luz D Orozco; Calvin Pan; Matteo Pellegrini; Hong Xiu Qi; Nathan Siemers; Pingzi Wen; Roumyana Yordanova; Brian J Bennett; Nam Che; Charles R Farber; Peter Gargalovic; Anatole Ghazalpour; Todd Kirchgessner; Adonisa Mutukulu; Isaac Neuhaus; Aldons J Lusis
Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages.
Cell 2012;151(3):658-70.
2012: Juyong Brian Kim; Lawrence W Castellani; Sarada Charugundla; Mete Civelek; Andres Deluna; Hieronim Jakobowski; Imran N Mungrue; Luz Orozco; Delila Pouldar; Marta Rusek; Christine Vu; Xuping Wang; Judy Wu; Aldons J Lusis
Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice.
Circulation 2012;126(15):1896-906.
2012: Sangderk Lee; Aldons J Lusis; Casey E Romanoski; James R Springstead; Konstantin G Birukov; Judith A Berliner
Role of phospholipid oxidation products in atherosclerosis.
Circulation research 2012;111(6):778-99.
2012: Lisa J Martin; Margarete Mehrabian; Imran Mungrue; Peipei Ping; Karen Reue; Diana Shih; Harpreet singh; Enrico Stefani; Elizabeth J Tarling; Laurent Vergnes; Sheila Xiao; Kristina Bostrom; Lawrence Castellani; Thomas A Drake; Edward Lau; Aldons J Lusis
ABCC6 localizes to the mitochondria-associated membrane.
Circulation research 2012;111(5):516-20.
2012: James N Weiss; Nicholas Wisniewski; Mario Deng; Eleazar Eskin; Steve Horvath; Alain Karma; W Robb MacLellan; Zhilin Qu; Christoph D Rau; Colin M Rees; Jessica Wang; Yibin Wang; Aldons J Lusis
"Good enough solutions" and the genetics of complex diseases.
Circulation research 2012;111(4):493-504.
2012: Brian J Bennett; Marchien Dallinga; Ayca Erbilgin; Eleazar Eskin; Bo Guan; Emrah Kostem; Isaac Neuhaus; Luz Orozco; Xuping Wang; Aldons J Lusis
High-resolution association mapping of atherosclerosis loci in mice.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(8):1790-8.
2012: Elaine M Smolock; Aldons J Lusis; Arkady N Murashev; Janice Gerloff; Anatole Ghazalpour; Irina A Ilyushkina; Vyacheslav A Korshunov
Genetic locus on mouse chromosome 7 controls elevated heart rate.
Physiological genomics 2012;44(13):689-98.
2012: Alena Stancáková; Aldons J Lusis; Mario A Morken; Jussi Paananen; Päivi Pajukanta; Jussi Pihlajamäki; Niyas K Saleem; Pasi Soininen; Mika Ala-Korpela; Michael Boehnke; Lori L Bonnycastle; Henna Cederberg; Mete Civelek; Francis S Collins; Antti J Kangas; Johanna Kuusisto; Markku Laakso
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men.
Diabetes 2012;61(7):1895-902.
2012: Nicholas A Furlotte; Eun Yong Kang; Aldons J Lusis; Atila Van Nas; Charles R Farber; Eleazar Eskin
Increasing association mapping power and resolution in mouse genetic studies through the use of meta-analysis for structured populations.
Genetics 2012;191(3):959-67.
2012: Aldons J Lusis
Genetics of atherosclerosis.
Trends in genetics : TIG 2012;28(6):267-75.
2012: Cynthia Hong; Aldons J Lusis; Susan Realegeno; Srinivasa T Reddy; Xin Rong; Jon Salazar; Rajendra K Tangirala; Rima Boyadjian; Michelle N Bradley; Lawrence W Castellani; Alan M Fogelman; Victor Grijalva; Brian J Van Lenten; Alan Wagner; Xuping Wang; Peter Tontonoz
LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.
Journal of lipid research 2012;53(6):1126-33.
2012: Arthur P Arnold; Aldons J Lusis
Understanding the sexome: measuring and reporting sex differences in gene systems.
Endocrinology 2012;153(6):2551-5.
2012: Sangderk Lee; Aldons J Lusis; Phuc Nguyen; Roland Palvolgyi; Brian W Parks; Casey E Romanoski; James R Springstead; Tiffany Ho; Judith A Berliner
Metalloproteinase processing of HBEGF is a proximal event in the response of human aortic endothelial cells to oxidized phospholipids.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(5):1246-54.
2012: W Robb MacLellan; Yibin Wang; Aldons J Lusis
Systems-based approaches to cardiovascular disease.
Nature reviews. Cardiology 2012;9(3):172-84.
2012: Peter Langfelder; Aldons J Lusis; Lawrence W Castellani; Richard Davis; Steve Horvath; Eric Paul; Eric E Schadt; Zhiqiang Zhou; Margarete Mehrabian
A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models.
Biochimica et biophysica acta 2012;1821(3):435-47.
2012: Aldons J Lusis
Life after GWAS: functional genomics in vascular biology.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(2):169.
2012: Christopher T Johansen; Sekar Kathiresan; Matthew Lanktree; Ann-Hwee Lee; Aldons J Lusis; Rebecca A Martins; Adam D McIntyre; Margarete Mehrabian; Miklós Péterfy; Jian Wang; Salim Yusuf; Sonia S Anand; Matthew R Ban; Henian Cao; Laurie H Glimcher; Murray W Huff; Robert A Hegele
Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia.
Circulation. Cardiovascular genetics 2012;5(1):66-72.
2012: Richard C Davis; Karl W Broman; Lawrence W Castellani; Miklós Péterfy; Hongxiu Qi; Melenie Rosales; Eric E Schadt; Atila Van Nas; Pingzi Wen; Suzanne Yu; Yi Zhao; Zhiqiang Zhou; Aldons J Lusis
Systems genetics of susceptibility to obesity-induced diabetes in mice.
Physiological genomics 2012;44(1):1-13.
2012: Gina Calabrese; Olivier De Backer; Carlos Dombret; Eleazar Eskin; Hyun M Kang; Aldons J Lusis; Luz Orozco; Brian J Bennett; Charles R Farber
Systems genetic analysis of osteoblast-lineage cells.
PLoS genetics 2012;8(12):e1003150.
2012: Kazunobu Ishikawa; Mohamad Navab; Aldons J Lusis
Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice.
International journal of hypertension 2012;2012():948203.
2011: Imran N Mungrue; Christoph Rau; Yucheng Yao; Peng Zhao; Arthur A B Bergen; Kristina I Boström; Thomas A Drake; Theo G M F Gorgels; Jocelyn V Havel; W Robb MacLellan; Haijin Meng; Aldons J Lusis
Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(12):2806-12.
2011: Juyong Brian Kim; Sangderk Lee; Aldons J Lusis; YongHong Meng; Zachary Port; Srinivasa T Reddy; Casey E Romanoski; Yi-Shou Shi; Judith A Berliner; Noam Bourquard; Ke Wei Gong; Victor Grijalva; Yu-Rong Xia; Diana M Shih
Paraoxonase-2 modulates stress response of endothelial cells to oxidized phospholipids and a bacterial quorum-sensing molecule.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(11):2624-33.
2011: Casey E Romanoski; Ladan Vakili; Wen-Pin Yang; Fen Yin; Jesus A Araujo; Judith A Berliner; Nam Che; Mete Civelek; Paul Kayne; Sangderk Lee; Nguyen Mai; Imran N Mungrue; Calvin Pan; Delila Pouldar; Aldons J Lusis
Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1.
Circulation research 2011;109(5):e27-41.
2011: Christian Besler; Angeliki Chroni; Roberto Corti; Georgios Daniil; Carola Doerries; Alan M Fogelman; Clement Furlong; Kathrin Heinrich; Alexander Akhmedov; Thomas F Lüscher; Aldons J Lusis; Willibald Maier; Costantina Manes; Christian M Matter; Maja Mueller; Meliana Riwanto; Lucia Rohrer; Nicola Schaefer; Diana M Shih; Sokrates Stein; Felix C Tanner; Christian Templin; Arnold von Eckardstein; Christophe Wyss; Keiko Yonekawa; Ulf Landmesser
Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease.
The Journal of clinical investigation 2011;121(7):2693-708.
2011: Anatole Ghazalpour; Raffi Hagopian; Hyun M Kang; Todd Kirchgessner; Brian Bennett; Heather Brewer; David G Camp; Eleazar Eskin; Charles Farber; Nicholas Furlotte; Peter Gargalovic; Imran N Mungrue; Isaac Neuhaus; Luz Orozco; Calvin Pan; Christopher C Park; Vladislav A Petyuk; Nathan Siemers; Janet Sinsheimer; Desmond J Smith; Richard D Smith; Charles Tilford; Karl Weitz; Ping-Zi Wen; Roumyana Yordanova; Aldons J Lusis
Comparative analysis of proteome and transcriptome variation in mouse.
PLoS genetics 2011;7(6):e1001393.
2011: Mete Civelek; Aldons J Lusis
Conducting the metabolic syndrome orchestra.
Nature genetics 2011;43(6):506-8.
2011: Zeneng Wang; Elizabeth Klipfell; Brian J Bennett; Robert Koeth; Bruce Levison; Brandon Dugar; Ariel E Feldstein; Earl B Britt; Xiaoming Fu; Yoon-Mi Chung; Yuping Wu; Phil Schauer; Jonathan D Smith; Hooman Allayee; W H Wilson Tang; Joseph A DiDonato; Aldons J Lusis; Stanley L Hazen
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
Nature 2011;472(7341):57-63.
2011: Charles Farber; Brian J Bennett; Luz Orozco; Wei Zou; Ana Lira; Emrah Kostem; Hyun Min Kang; Nicholas Furlotte; Ani Berberyan; Anatole Ghazalpour; Jaijam Suwanwela; Thomas A Drake; Eleazar Eskin; Q Tian Wang; Steven L Teitelbaum; Aldons J Lusis
Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis.
PLoS genetics 2011;7(4):e1002038.
2011: Jaijam Suwanwela; Charles R Farber; Bau-Lin Haung; Buer Song; Calvin Pan; Karen M Lyons; Aldons J Lusis
Systems genetics analysis of mouse chondrocyte differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(4):747-60.
2011: Christopher C Park; Greg D Gale; Simone de Jong; Anatole Ghazalpour; Brian J Bennett; Charles Farber; Peter Langfelder; Andy Lin; Arshad H Khan; Eleazar Eskin; Steve Horvath; Aldons J Lusis; Roel A Ophoff; Desmond J Smith
Gene networks associated with conditional fear in mice identified using a systems genetics approach.
BMC systems biology 2011;5():43.
2011: Berenice Barajas; Nam Che; Fen Yin; Amir Rowshanrad; Luz D Orozco; Ke Wei Gong; Xuping Wang; Lawrence W Castellani; Karen Reue; Aldons J Lusis; Jesus A Araujo
NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(1):58-66.
2010: Yucheng Yao; Brian J Bennett; Xuping Wang; Michael E Rosenfeld; Cecilia Giachelli; Aldons J Lusis; Kristina I Boström
Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification.
Circulation research 2010;107(4):485-94.
2010: Xia Yang; Larry Peterson; Rolf Thieringer; Joshua L Deignan; Xuping Wang; Jun Zhu; Susanna Wang; Hua Zhong; Serguei Stepaniants; John Beaulaurier; I-Ming Wang; Ray Rosa; Anne-Marie Cumiskey; Jane Ming-Juan Luo; Qi Luo; Kashmira Shah; Jianying Xiao; David Nickle; Andrew Plump; Eric E Schadt; Aldons J Lusis; Pek Yee Lum
Identification and validation of genes affecting aortic lesions in mice.
The Journal of clinical investigation 2010;120(7):2414-22.
2010: Atila Van Nas; Leslie Ingram-Drake; Janet S Sinsheimer; Susanna S Wang; Eric E Schadt; Thomas Drake; Aldons J Lusis
Expression quantitative trait loci: replication, tissue- and sex-specificity in mice.
Genetics 2010;185(3):1059-68.
2010: Richard C Davis; Lawrence W Castellani; Maryam Hosseini; Osnat Ben-Zeev; Hui Z Mao; Michael M Weinstein; Dae Young Jung; John Y Jun; Jason K Kim; Aldons J Lusis; Miklós Péterfy
Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice.
Diabetes 2010;59(7):1616-25.
2010: Zory Shaposhnik; Xuping Wang; Aldons J Lusis
Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis.
Journal of lipid research 2010;51(7):1962-70.
2010: Yi-Hsiang Hsu; M Carola Zillikens; Scott G Wilson; Charles R Farber; Serkalem Demissie; Nicole Soranzo; Estelle Bianchi; Elin Grundberg; Liming Liang; J Brent Richards; Karol Estrada; Yanhua Zhou; Atila Van Nas; Miriam F Moffatt; Guangju Zhai; Albert Hofman; Joyce B van Meurs; Huibert A P Pols; Roger I Price; Olle Nilsson; Tomi Pastinen; L Adrienne Cupples; Aldons J Lusis; Eric E Schadt; Serge Ferrari; André G Uitterlinden; Fernando Rivadeneira; Timothy D Spector; David Karasik; Douglas P Kiel
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
PLoS genetics 2010;6(6):e1000977.
2010: Elizabeth J Tarling; Dragana D Bojanic; Rajendra K Tangirala; Xuping Wang; Anita Lovgren-Sandblom; Aldons J Lusis; Ingemar Bjorkhem; Peter A Edwards
Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(6):1174-80.
2010: Casey E Romanoski; Sangderk Lee; Michelle J Kim; Leslie Ingram-Drake; Christopher Plaisier; Roumyana Yordanova; Charles Tilford; Bo Guan; Aiqing He; Peter S Gargalovic; Todd G Kirchgessner; Judith A Berliner; Aldons J Lusis
Systems genetics analysis of gene-by-environment interactions in human cells.
American journal of human genetics 2010;86(3):399-410.
2010: Saul J Priceman; James L Sung; Zory Shaposhnik; Jeremy B Burton; Antoni X Torres-Collado; Diana L Moughon; Mai Johnson; Aldons J Lusis; Donald A Cohen; M Luisa Iruela-Arispe; Lily Wu
Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.
Blood 2010;115(7):1461-71.
2010: Sulin Wu; Rebecca Mar-Heyming; Eric Z Dugum; Nicholas A Kolaitis; Hongxiu Qi; Päivi Pajukanta; Lawrence W Castellani; Aldons J Lusis; Thomas A Drake
Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice.
Human molecular genetics 2010;19(4):597-608.
2010: Peter Gargalovic; Ayça Erbilgin; Omid Kohannim; Joanne Pagnon; Xuping Wang; Lawrence Castellani; Renee LeBoeuf; Martha L Peterson; Brett T Spear; Aldons J Lusis
Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism.
Circulation. Cardiovascular genetics 2010;3(1):60-7.
2010: Brian J Bennett; Charles Farber; Luz Orozco; Hyun Min Kang; Anatole Ghazalpour; Nathan Siemers; Michael Neubauer; Isaac Neuhaus; Roumyana Yordanova; Bo Guan; Amy Truong; Wen-Pin Yang; Aiqing He; Paul Kayne; Peter Gargalovic; Todd Kirchgessner; Calvin Pan; Lawrence W Castellani; Emrah Kostem; Nicholas Furlotte; Thomas A Drake; Eleazar Eskin; Aldons J Lusis
A high-resolution association mapping panel for the dissection of complex traits in mice.
Genome research 2010;20(2):281-90.
2010: Aldons J Lusis; James N Weiss
Cardiovascular networks: systems-based approaches to cardiovascular disease.
Circulation 2010;121(1):157-70.
2010: Jennifer M P Woo; Zhuofeng Lin; Mohamad Navab; Casey Van Dyck; Yvette Trejo-Lopez; Krystal M T Woo; Hongyun Li; Lawrence W Castellani; Xuping Wang; Noriko Iikuni; Ornella J Rullo; Hui Wu; Antonio La Cava; Alan M Fogelman; Aldons J Lusis; Betty P Tsao
Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis.
Arthritis research & therapy 2010;12(3):R93.
2010: Diana M Shih; Yu-Rong Xia; Janet M Yu; Aldons J Lusis
Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis.
Advances in experimental medicine and biology 2010;660():73-87.
2010: Michael M Weinstein; Liya Yin; Yiping Tu; Xuping Wang; Xiaohui Wu; Lawrence W Castellani; Rosemary Walzem; Aldons J Lusis; Loren G Fong; Anne P Beigneux; Stephen G Young
Chylomicronemia elicits atherosclerosis in mice--brief report.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(1):20-3.
2009: David A Stoltz; Egon A Ozer; Thomas J Recker; Miriam Estin; Xia Yang; Diana M Shih; Aldons J Lusis; Joseph Zabner
A common mutation in paraoxonase-2 results in impaired lactonase activity.
The Journal of biological chemistry 2009;284(51):35564-71.
2009: Susanna S Wang; Lisa J Martin; Eric E Schadt; Haijin Meng; Xuping Wang; Wei Zhao; Leslie Ingram-Drake; Martina Nebohacova; Margarete Mehrabian; Thomas A Drake; Aldons J Lusis
Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice.
Circulation. Cardiovascular genetics 2009;2(6):573-82.
2009: Charles R Farber; Aldons J Lusis
Future of osteoporosis genetics: enhancing genome-wide association studies.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(12):1937-42.
2009: Arthur P Arnold; Atila Van Nas; Aldons J Lusis
Systems biology asks new questions about sex differences.
Trends in endocrinology and metabolism: TEM 2009;20(10):471-6.
2009: Luz D Orozco; Shawn Cokus; Anatole Ghazalpour; Leslie Ingram-Drake; Susanna Wang; Atila Van Nas; Nam Che; Jesus A Araujo; Matteo Pellegrini; Aldons J Lusis
Copy number variation influences gene expression and metabolic traits in mice.
Human molecular genetics 2009;18(21):4118-29.
2009: Diana M Shih; Aldons J Lusis
The roles of PON1 and PON2 in cardiovascular disease and innate immunity.
Current opinion in lipidology 2009;20(4):288-92.
2009: G D Gale; R D Yazdi; Arshad H Khan; Aldons J Lusis; Richard C Davis; Desmond J Smith
A genome-wide panel of congenic mice reveals widespread epistasis of behavior quantitative trait loci.
Molecular psychiatry 2009;14(6):631-45.
2009: Charles Farber; Jason E Aten; Emily A Farber; Vincent de Vera; Rodrigo Gularte; Alma Islas-Trejo; Pengzi Wen; Steve Horvath; Michael Lucero; Aldons J Lusis; Juan F Medrano
Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling.
Physiological genomics 2009;37(3):294-302.
2009: Cory H White; Jeffrey D Ohmen; Sonal Sheth; Amina F Zebboudj; Richard K McHugh; Larry F Hoffman; Aldons J Lusis; Richard C Davis; Rick A Friedman
Genome-wide screening for genetic loci associated with noise-induced hearing loss.
Mammalian genome : official journal of the International Mammalian Genome Society 2009;20(4):207-13.
2009: Sulin Wu; Aldons J Lusis; Thomas A Drake
A systems-based framework for understanding complex metabolic and cardiovascular disorders.
Journal of lipid research 2009;50 Suppl():S358-63.
2009: Zory Shaposhnik; Xuping Wang; Joaquim Trias; Heather Fraser; Aldons J Lusis
The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002).
Journal of lipid research 2009;50(4):623-9.
2009: Brian J Bennett; Susanna S Wang; Xuping Wang; Xiaohui Wu; Aldons J Lusis
Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(3):348-55.
2009: Kum Kum S Bhasin; Atila Van Nas; Lisa J Martin; Richard C Davis; Sherin U Devaskar; Aldons J Lusis
Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction.
Diabetes 2009;58(3):559-66.
2009: Atila Van Nas; Debraj Guhathakurta; Susanna S Wang; Nadir Yehya; Steve Horvath; Bin Zhang; Leslie Ingram-Drake; Gautam Chaudhuri; Eric E Schadt; Thomas A Drake; Arthur P Arnold; Aldons J Lusis
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks.
Endocrinology 2009;150(3):1235-49.
2009: Imran N Mungrue; Joanne Pagnon; Omid Kohannim; Peter Gargalovic; Aldons J Lusis
CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):466-76.
2008: Aldons J Lusis; Alan D Attie; Karen Reue
Metabolic syndrome: from epidemiology to systems biology.
Nature reviews. Genetics 2008;9(11):819-30.
2008: Hooman Allayee; Ana Baylin; Jaana Hartiala; Hemani Wijesuriya; Margarete Mehrabian; Aldons J Lusis; HANNIA CAMPOS
Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction.
The American journal of clinical nutrition 2008;88(4):934-40.
2008: Junqin Chen; Simon T Hui; Francesca M Couto; Imran N Mungrue; Dawn B Davis; Alan D Attie; Aldons J Lusis; Roger A Davis; Anath Shalev
Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3581-94.
2008: Olga Oskolkova; Taras Afonyushkin; Alexander Leitner; Elena von Schlieffen; Peter S Gargalovic; Aldons J Lusis; Bernd R Binder; Valery N Bochkov
ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response.
Blood 2008;112(2):330-9.
2008: Margarete Mehrabian; F T Schulthess; M Nebohacova; Lawrence W Castellani; Z Zhou; Jaana Hartiala; José Oberholzer; Aldons J Lusis; Kathrin Maedler; Hooman Allayee
Identification of ALOX5 as a gene regulating adiposity and pancreatic function.
Diabetologia 2008;51(6):978-88.
2008: Rebecca Mar-Heyming; Makoto Miyazaki; Daphna Weissglas-Volkov; Nicholas A Kolaitis; Narimaan Sadaat; Christopher Plaisier; Päivi Pajukanta; Rita M Cantor; Tjerk W A de Bruin; James M Ntambi; Aldons J Lusis
Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(6):1193-9.
2008: Lawrence W Castellani; Cara N Nguyen; Sarada Charugundla; Michael M Weinstein; Chau X Doan; William S Blaner; Nuttaporn Wongsiriroj; Aldons J Lusis
Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance.
The Journal of biological chemistry 2008;283(17):11633-44.
2008: Christopher C Park; Sangtae Ahn; Joshua S Bloom; Andy Lin; Richard Wang; Tongtong Wu; Aswin Sekar; Arshad H Khan; Christine J Farr; Aldons J Lusis; Richard M Leahy; Kenneth Lange; Desmond J Smith
Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids.
Nature genetics 2008;40(4):421-9.
2008: Junqin Chen; Geetu Saxena; Imran N Mungrue; Aldons J Lusis; Anath Shalev
Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis.
Diabetes 2008;57(4):938-44.
2008: Yanqing Chen; Jun Zhu; Pek Yee Lum; Xia Yang; Shirly Pinto; Douglas J MacNeil; Chunsheng Zhang; john lamb; Stephen Wilton Edwards; Solveig K Sieberts; Amy Leonardson; Lawrence W Castellini; Susanna Wang; Marie-France Champy; Bin Zhang; Valur Emilsson; Sudheer Doss; Anatole Ghazalpour; Steve Horvath; Thomas A Drake; Aldons J Lusis; Eric E Schadt
Variations in DNA elucidate molecular networks that cause disease.
Nature 2008;452(7186):429-35.
2008: Tamali Bhattacharyya; Stephen J Nicholls; Eric J Topol; Renliang Zhang; Xia Yang; David Schmitt; Xiaoming Fu; Mingyuan Shao; Danielle M Brennan; Stephen G Ellis; Marie-Luise Brennan; Hooman Allayee; Aldons J Lusis; Stanley L Hazen
Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk.
JAMA : the journal of the American Medical Association 2008;299(11):1265-76.
2008: Jesus A Araujo; Berenice Barajas; Michael T Kleinman; Xuping Wang; Brian J Bennett; Ke Wei Gong; Mohamad Navab; Jack Harkema; Constantinos Sioutas; Aldons J Lusis; Andre E Nel
Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress.
Circulation research 2008;102(5):589-96.
2008: Jessica Pilar McLin; Leslie Michels Thompson; Aldons J Lusis; Richard C Davis; Oswald Steward
Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid.
Neurobiology of disease 2008;29(3):391-9.
2008: Aldons J Lusis; Päivi Pajukanta
A treasure trove for lipoprotein biology.
Nature genetics 2008;40(2):129-30.
2008: Anatole Ghazalpour; Sudheer Doss; Hyun Kang; Charles Farber; Ping-Zi Wen; Alec Brozell; Ruth Castellanos; Eleazar Eskin; Desmond J Smith; Thomas A Drake; Aldons J Lusis
High-resolution mapping of gene expression using association in an outbred mouse stock.
PLoS genetics 2008;4(8):e1000149.
2008: Jason E Aten; Tova F Fuller; Aldons J Lusis; Steve Horvath
Using genetic markers to orient the edges in quantitative trait networks: the NEO software.
BMC systems biology 2008;2():34.
2008: Charles Farber; Aldons J Lusis
Integrating global gene expression analysis and genetics.
Advances in genetics 2008;60():571-601.
2007: Susanna S Wang; Weibin Shi; Xuping Wang; Leandra Velky; Sarah Greenlee; Min T Wang; Thomas A Drake; Aldons J Lusis
Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(12):2671-6.
2007: Miklós Péterfy; Richard C Davis; Aldons J Lusis
Metabolic syndrome as a modifier of atherosclerosis in murine models.
Current drug targets 2007;8(11):1215-20.
2007: Brian J Bennett; Casey E Romanoski; Aldons J Lusis
Network-centered view of coronary artery disease.
Expert review of cardiovascular therapy 2007;5(6):1095-103.
2007: Aldons J Lusis; Janet Yu; Susanna S Wang
The problem of passenger genes in transgenic mice.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(10):2100-3.
2007: Jenny C Lee; Daphna Weissglas-Volkov; Mira Kyttälä; Janet S Sinsheimer; Anne Jokiaho; Tjerk W A de Bruin; Aldons J Lusis; Marie-Luise Brennan; Marleen M J van Greevenbroek; Carla J H van der Kallen; Stanley L Hazen; Päivi Pajukanta
USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(10):2222-7.
2007: Corina J A Moen; Aart P Tholens; Peter J Voshol; Willeke de Haan; Louis M Havekes; Peter Gargalovic; Aldons J Lusis; Ko Willems van Dyk; Rune R Frants; Marten H Hofker; Patrick Rensen
The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides.
Journal of lipid research 2007;48(10):2182-92.
2007: Richard C Davis; Angela Jin; Melenie Rosales; Suzanne Yu; Xiaoyu Xia; Kathleen Ranola; Eric E Schadt; Aldons J Lusis
A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background.
Genomics 2007;90(3):306-13.
2007: Susanna S Wang; Eric E Schadt; Hui Wang; Xuping Wang; Leslie Ingram-Drake; Weibin Shi; Thomas A Drake; Aldons J Lusis
Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data.
Circulation research 2007;101(3):e11-30.
2007: Michelle N Bradley; Cynthia Hong; Mingyi Chen; Sean B Joseph; DAMIEN WILPITZ; Xuping Wang; Aldons J Lusis; Allan Collins; Willa A Hseuh; Jon L Collins; Rajendra K Tangirala; Peter Tontonoz
Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.
The Journal of clinical investigation 2007;117(8):2337-46.
2007: Tova F Fuller; Anatole Ghazalpour; Jason E Aten; Thomas A Drake; Aldons J Lusis; Steve Horvath
Weighted gene coexpression network analysis strategies applied to mouse weight.
Mammalian genome : official journal of the International Mammalian Genome Society 2007;18(6-7):463-72.
2007: Luz D Orozco; Matthias H Kapturczak; Berenice Barajas; Xuping Wang; Michael M Weinstein; Jack Wong; Jessy Deshane; Subhashini Bolisetty; Zory Shaposhnik; Diana M Shih; Anupam Agarwal; Aldons J Lusis; Jesus A Araujo
Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis.
Circulation research 2007;100(12):1703-11.
2007: Nima M Gharavi; Peter Gargalovic; Irene Chang; Jesus A Araujo; Michael Clark; Wan Lam Szeto; Andrew D Watson; Aldons J Lusis; Judith A Berliner
High-density lipoprotein modulates oxidized phospholipid signaling in human endothelial cells from proinflammatory to anti-inflammatory.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(6):1346-53.
2007: Diana M Shih; Yu-Rong Xia; Xu-Ping Wang; Susanna S Wang; Noam Bourquard; Alan M Fogelman; Aldons J Lusis; Srinivasa T Reddy
Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice.
Circulation research 2007;100(8):1200-7.
2007: Xuebing Feng; Hongyun Li; Alexis A Rumbin; Xuping Wang; Antonio La Cava; Katherine Brechtelsbauer; Lawrence W Castellani; Joseph L Witztum; Aldons J Lusis; Betty P Tsao
ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia.
Journal of lipid research 2007;48(4):794-805.
2007: David A Stoltz; Egon A Ozer; Carey J Ng; Janet M Yu; Srinivasa T Reddy; Aldons J Lusis; Noam Bourquard; Matthew R Parsek; Joseph Zabner; Diana M Shih
Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia.
American journal of physiology. Lung cellular and molecular physiology 2007;292(4):L852-60.
2007: Haijin Meng; Iset Vera; Nam Che; Xuping Wang; Susanna S Wang; Leslie Ingram-Drake; Eric E Schadt; Thomas A Drake; Aldons J Lusis
Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4530-5.
2007: Zory Shaposhnik; Xuping Wang; Michael Weinstein; Brian J Bennett; Aldons J Lusis
Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesions.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(3):621-7.
2007: Ke Wei Gong; Wei Zhao; Ning Li; Berenice Barajas; Michael T Kleinman; Constantinos Sioutas; Steve Horvath; Aldons J Lusis; Andre E Nel; Jesus A Araujo
Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells.
Genome biology 2007;8(7):R149.
2007: Yuichiro Itoh; Esther Melamed; Xia Yang; Kathy Kampf; Susanna Wang; Nadir Yehya; Atila Van Nas; Kirstin Replogle; Mark R Band; David F Clayton; Eric E Schadt; Aldons J Lusis; Arthur P Arnold
Dosage compensation is less effective in birds than in mammals.
Journal of biology 2007;6(1):2.
2006: Brian W Parks; Aldons J Lusis; Janusz H S Kabarowski
Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(12):2703-9.
2006: Martijn C G J Brouwers; Rita M Cantor; Naoko Kono; Jeong Lim Yoon; Carla J H van der Kallen; Monique A L Bilderbeek-Beckers; Marleen M J van Greevenbroek; Aldons J Lusis; Tjerk W A de Bruin
Heritability and genetic loci of fatty liver in familial combined hyperlipidemia.
Journal of lipid research 2006;47(12):2799-807.
2006: Peter Gargalovic; Nima M Gharavi; Michael Clark; Joanne Pagnon; Wen-Pin Yang; Aiqing He; Amy Truong; Tamar Baruch-Oren; Judith A Berliner; Todd G Kirchgessner; Aldons J Lusis
The unfolded protein response is an important regulator of inflammatory genes in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(11):2490-6.
2006: Kum Kum Bhasin; Janet M Yu; Aaron D Tward; Diana M Shih; David A Campbell; Aldons J Lusis
Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice.
Experimental parasitology 2006;114(3):240-5.
2006: Carey J Ng; Noam Bourquard; Victor Grijalva; Susan Hama; Diana M Shih; Mohamad Navab; Alan M Fogelman; Aldons J Lusis; Stephen Young; Srinivasa T Reddy
Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2.
The Journal of biological chemistry 2006;281(40):29491-500.
2006: Yanqiao Zhang; Xuping Wang; Charisse Vales; Florence Ying Lee; Hans Lee; Aldons J Lusis; Peter A Edwards
FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2316-21.
2006: Aldons J Lusis
A thematic review series: systems biology approaches to metabolic and cardiovascular disorders.
Journal of lipid research 2006;47(9):1887-90.
2006: Peter Gargalovic; Minori Imura; Bin Zhang; Nima M Gharavi; Michael Clark; Joanne Pagnon; Wen-Pin Yang; Aiqing He; Amy Truong; Shilpa Patel; Stanley F Nelson; Steve Horvath; Judith A Berliner; Todd G Kirchgessner; Aldons J Lusis
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(34):12741-6.
2006: Anatole Ghazalpour; Sudheer Doss; Bin Zhang; Susanna Wang; Christopher Plaisier; Ruth Castellanos; Alec Brozell; Eric E Schadt; Thomas A Drake; Aldons J Lusis; Steve Horvath
Integrating genetic and network analysis to characterize genes related to mouse weight.
PLoS genetics 2006;2(8):e130.
2006: Daria Estrada-Smith; Alan R Collins; Xuping Wang; Craig Crockett; Lawrence W Castellani; Aldons J Lusis; Richard C Davis
Impact of chromosome 2 obesity loci on cardiovascular complications of insulin resistance in LDL receptor-deficient C57BL/6 mice.
Diabetes 2006;55(8):2265-71.
2006: Xia Yang; Eric E Schadt; Susanna Wang; Hui Wang; Arthur P Arnold; Leslie Ingram-Drake; Thomas A Drake; Aldons J Lusis
Tissue-specific expression and regulation of sexually dimorphic genes in mice.
Genome research 2006;16(8):995-1004.
2006: Toru Miyoshi; Yuhua Li; Diana M Shih; Xuping Wang; Victor E Laubach; Alan H Matsumoto; Gregory A Helm; Aldons J Lusis; Weibin Shi
Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice.
Life sciences 2006;79(6):525-31.
2006: Lawrence W Castellani; James J Chang; Xuping Wang; Aldons J Lusis; Wanda F Reynolds
Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males.
Journal of lipid research 2006;47(7):1366-77.
2006: Sonal S Sheth; Jackie S Bodnar; Anatole Ghazalpour; C K Thipphavong; S Tsutsumi; Aaron D Tward; Peter Demant; T Kodama; H Aburatani; Aldons J Lusis
Hepatocellular carcinoma in Txnip-deficient mice.
Oncogene 2006;25(25):3528-36.
2006: Thomas A Drake; Eric E Schadt; Aldons J Lusis
Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2006;17(6):466-79.
2006: Martijn C G J Brouwers; Naoko Kono; Marleen M J van Greevenbroek; Carla J H van der Kallen; Aldons J Lusis; Tjerk W A de Bruin; Rita M Cantor
Longitudinal differences in familial combined hyperlipidemia quantitative trait loci.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(6):e118-9.
2006: Anatole Ghazalpour; Xuping Wang; Aldons J Lusis; Margarete Mehrabian
Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice.
Genetics 2006;173(2):943-51.
2006: Zhi-Guang Su; Yuhua Li; Jessica C James; Alan H Matsumoto; Gregory A Helm; Aldons J Lusis; Weibin Shi
Genetic linkage of hyperglycemia, body weight and serum amyloid-P in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice.
Human molecular genetics 2006;15(10):1650-8.
2006: Pek Yee Lum; Yanqing Chen; Jun Zhu; john lamb; Shlomo Melmed; Susanna Wang; Tom A Drake; Aldons J Lusis; Eric E Schadt
Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes.
Journal of neurochemistry 2006;97 Suppl 1():50-62.
2006: Jenny C Lee; Aldons J Lusis; Päivi Pajukanta
Familial combined hyperlipidemia: upstream transcription factor 1 and beyond.
Current opinion in lipidology 2006;17(2):101-9.
2006: Zhi-Guang Su; Yuhua Li; Jessica C James; Marcia McDuffie; Alan H Matsumoto; Gregory A Helm; James L Weber; Aldons J Lusis; Weibin Shi
Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene.
Genetics 2006;172(3):1799-807.
2006: Susanna Wang; Nadir Yehya; Eric E Schadt; Hui Wang; Thomas A Drake; Aldons J Lusis
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity.
PLoS genetics 2006;2(2):e15.
2006: Diana M Shih; Heidi R Kast-Woelbern; Jack Wong; Yu-Rong Xia; Peter A Edwards; Aldons J Lusis
A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids.
Journal of lipid research 2006;47(2):384-92.
2005: Egon A Ozer; Alejandro Pezzulo; Diana M Shih; Carlene K Chun; Clement E Furlong; Aldons J Lusis; E Peter Greenberg; Joseph Zabner
Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing.
FEMS microbiology letters 2005;253(1):29-37.
2005: Thomas A Drake; Eric E Schadt; Richard C Davis; Aldons J Lusis
Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice.
American journal of therapeutics 2005;12(6):503-11.
2005: Margarete Mehrabian; Hooman Allayee; Jirina Stockton; Pek Yee Lum; Thomas A Drake; Lawrence W Castellani; Michael Suh; Christopher Armour; Stephen Wilton Edwards; john lamb; Aldons J Lusis; Eric E Schadt
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits.
Nature genetics 2005;37(11):1224-33.
2005: Alessandra C L Cervino; Guoya Li; Stephen Wilton Edwards; Jun Zhu; Cathy Laurie; George Tokiwa; Pek Yee Lum; Susanna Wang; Lawrence W Castellani; Lawrence W Castellini; Aldons J Lusis; Sonia Carlson; Alan Sachs; Eric E Schadt
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels.
Genomics 2005;86(5):505-17.
2005: Richard C Davis; Eric E Schadt; Desmond J Smith; Elena W Y Hsieh; Alessandra C L Cervino; Atila Van Nas; Melenie Rosales; Sudheer Doss; Haijin Meng; Hooman Allayee; Aldons J Lusis
A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background.
Genomics 2005;86(3):259-70.
2005: Adriana Huertas-Vazquez; Carlos Aguilar Salinas; Aldons J Lusis; Rita M Cantor; Samuel Canizales-Quinteros; Jenny C Lee; Lizzette Mariana-Nuñez; Roopa-Metha Laura Riba-Ramirez; Anne Jokiaho; Teresa Tusie-Luna; Päivi Pajukanta
Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(9):1985-91.
2005: Clement E Furlong; Toby B Cole; Gail P Jarvik; Christina Pettan-Brewer; Gary K Geiss; Rebecca J Richter; Diana M Shih; Aaron D Tward; Aldons J Lusis; Lucio G Costa
Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants.
Neurotoxicology 2005;26(4):651-9.
2005: Toby B Cole; Betsy J Walter; Diana M Shih; Aaron D Tward; Aldons J Lusis; Charles Timchalk; Rebecca J Richter; Lucio G Costa; Clement E Furlong
Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism.
Pharmacogenetics and genomics 2005;15(8):589-98.
2005: Eric E Schadt; john lamb; Xia Yang; Jun Zhu; Stephen Wilton Edwards; Debraj GuhaThakurta; Solveig K Sieberts; Stephanie Monks; Marc Reitman; Chunsheng Zhang; Pek Yee Lum; Amy Leonardson; Rolf Thieringer; Joseph M Metzger; Liming Yang; John Castle; Haoyuan Zhu; Shera F Kash; Thomas A Drake; Alan Sachs; Aldons J Lusis
An integrative genomics approach to infer causal associations between gene expression and disease.
Nature genetics 2005;37(7):710-7.
2005: Brian W Parks; Ginger P Gambill; Aldons J Lusis; Janusz H S Kabarowski
Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient mice.
Journal of lipid research 2005;46(7):1405-15.
2005: Hal X Nguyen; Aldons J Lusis; James G Tidball
Null mutation of myeloperoxidase in mice prevents mechanical activation of neutrophil lysis of muscle cell membranes in vitro and in vivo.
The Journal of physiology 2005;565(Pt 2):403-13.
2005: Sudheer Doss; Eric E Schadt; Thomas A Drake; Aldons J Lusis
Cis-acting expression quantitative trait loci in mice.
Genome research 2005;15(5):681-91.
2005: Richard C Davis; Eric E Schadt; Alessandra C L Cervino; Miklós Péterfy; Aldons J Lusis
Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility.
Diabetes 2005;54(4):1191-9.
2005: Anatole Ghazalpour; Sudheer Doss; Sonal S Sheth; Leslie Ingram-Drake; Eric E Schadt; Aldons J Lusis; Thomas A Drake
Genomic analysis of metabolic pathway gene expression in mice.
Genome biology 2005;6(7):R59.
2005: Clement E Furlong; Toby B Cole; Betsy J Walter; Diana M Shih; Aaron D Tward; Aldons J Lusis; Charles Timchalk; Rebecca J Richter; Lucio G Costa
Paraoxonase 1 (PON1) status and risk of insecticide exposure.
Journal of biochemical and molecular toxicology 2005;19(3):182-3.
2005: Sonal S Sheth; Lawrence W Castellani; Soumya Chari; Cory Wagg; Christopher K Thipphavong; Jackie S Bodnar; Peter Tontonoz; Alan D Attie; Gary D Lopaschuk; Aldons J Lusis
Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.
Journal of lipid research 2005;46(1):123-34.
2004: Lawrence W Castellani; Peter Gargalovic; Maria Febbraio; Sarada Charugundla; Ming-Len Jien; Aldons J Lusis
Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-II.
Journal of lipid research 2004;45(12):2377-87.
2004: Aldons J Lusis; Alan M Fogelman; Gregg C Fonarow
Genetic basis of atherosclerosis: part II: clinical implications.
Circulation 2004;110(14):2066-71.
2004: Xuping Wang; Peter Gargalovic; Jack Wong; Jennifer L Gu; Xiaohui Wu; Hongxiu Qi; Pingzi Wen; Li Xi; Bing Tan; Rocky Gogliotti; Lawrence W Castellani; Aurobindo Chatterjee; Aldons J Lusis
Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(10):1928-34.
2004: Rita M Cantor; Tjerk W A de Bruin; Naoko Kono; Susan Napier Thomas; Atila Van Nas; Hooman Allayee; Aldons J Lusis
Quantitative trait loci for apolipoprotein B, cholesterol, and triglycerides in familial combined hyperlipidemia pedigrees.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(10):1935-41.
2004: Anatole Ghazalpour; Sudheer Doss; Xia Yang; Jason Aten; Edward M Toomey; Atila Van Nas; Susanna Wang; Thomas A Drake; Aldons J Lusis
Thematic review series: The pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis.
Journal of lipid research 2004;45(10):1793-805.
2004: Aldons J Lusis; Alan M Fogelman; Gregg C Fonarow
Genetic basis of atherosclerosis: part I: new genes and pathways.
Circulation 2004;110(13):1868-73.
2004: Jacob M Rothfork; Graham S Timmins; Michael N Harris; Xian Chen; Aldons J Lusis; Michael Otto; Ambrose L Cheung; Hattie D Gresham
Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13867-72.
2004: To Yuen Hui; Sonal S Sheth; J Matthew Diffley; Douglas W Potter; Aldons J Lusis; Alan D Attie; Roger A Davis
Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals.
The Journal of biological chemistry 2004;279(23):24387-93.
2004: Kerry L Donnelly; Mark R Margosian; Sonal S Sheth; Aldons J Lusis; Elizabeth J Parks
Increased lipogenesis and fatty acid reesterification contribute to hepatic triacylglycerol stores in hyperlipidemic Txnip-/- mice.
The Journal of nutrition 2004;134(6):1475-80.
2004: Morry D Brown; Li Jin; Ming-Len Jien; Alan H Matsumoto; Gregory A Helm; Aldons J Lusis; Joy S Frank; Weibin Shi
Lipid retention in the arterial wall of two mouse strains with different atherosclerosis susceptibility.
Journal of lipid research 2004;45(6):1155-61.
2004: Mohamad Navab; G M Ananthramaiah; Srinivasa T Reddy; Brian J Van Lenten; Benjamin J Ansell; Gregg C Fonarow; Kambiz Vahabzadeh; Susan Hama; Greg Hough; Naeimeh Kamranpour; Judith A Berliner; Aldons J Lusis; Alan M Fogelman
The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL.
Journal of lipid research 2004;45(6):993-1007.
2004: Weibin Shi; Xuping Wang; Jack Wong; Catherine C Hedrick; Howard Wong; Lawrence W Castellani; Aldons J Lusis
Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice.
Biochemical and biophysical research communications 2004;317(1):223-9.
2004: Rebecca Mar; Päivi Pajukanta; Hooman Allayee; Martine Groenendijk; Geesje M Dallinga-Thie; Ronald M Krauss; Janet S Sinsheimer; Rita M Cantor; Tjerk W A de Bruin; Aldons J Lusis
Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia.
Circulation research 2004;94(7):993-9.
2004: Päivi Pajukanta; Heidi E Lilja; Janet S Sinsheimer; Rita M Cantor; Aldons J Lusis; Massimiliano Gentile; Xiaoqun Joyce Duan; Aino Soro-Paavonen; Jussi Naukkarinen; Janna Saarela; Markku Laakso; Christian Ehnholm; Marja-Riitta Taskinen; Leena Peltonen
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).
Nature genetics 2004;36(4):371-6.
2004: Carrie L Welch; Sara Seidelmann; Ping-Zi Wen; Margarete Mehrabian; Nashat Latib; Jamila Fruchart-Najib; Jean-Charles Fruchart; Christy Myrick; Aldons J Lusis
Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strain.
Physiological genomics 2004;17(1):48-59.
2004: Dahai Liu; Ram Pyare Singh; Arshad H Khan; Aldons J Lusis; Richard C Davis; Desmond J Smith
Mapping behavioral traits by use of genome-tagged mice.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2004;12(2):158-65.
2004: Aldons J Lusis; Rebecca Mar; Päivi Pajukanta
Genetics of atherosclerosis.
Annual review of genomics and human genetics 2004;5():189-218.
2004: Daria Estrada-Smith; Lawrence W Castellani; Howard Wong; Ping-Zi Wen; Aileen Chui; Aldons J Lusis; Richard C Davis
Dissection of multigenic obesity traits in congenic mouse strains.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(1):14-22.
2004: James H Dwyer; Hooman Allayee; Kathleen M Dwyer; Jing Fan; Huiyun Wu; Rebecca Mar; Aldons J Lusis; Margarete Mehrabian
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis.
The New England journal of medicine 2004;350(1):29-37.
2003: W Robb MacLellan; Aldons J Lusis
Dilated cardiomyopathy: learning to live with yourself.
Nature medicine 2003;9(12):1455-6.
2003: Dahai Liu; Ram Pyare Singh; Arshad H Khan; Kinnar Bhavsar; Aldons J Lusis; Richard C Davis; Desmond J Smith
Identifying loci for behavioral traits using genome-tagged mice.
Journal of neuroscience research 2003;74(4):562-9.
2003: Aldons J Lusis
Genetic factors in cardiovascular disease. 10 questions.
Trends in cardiovascular medicine 2003;13(8):309-16.
2003: Weibin Shi; Morry D Brown; Xuping Wang; Jack Wong; David F Kallmes; Alan H Matsumoto; Gregory A Helm; Thomas A Drake; Aldons J Lusis
Genetic backgrounds but not sizes of atherosclerotic lesions determine medial destruction in the aortic root of apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(10):1901-6.
2003: Hooman Allayee; Anatole Ghazalpour; Aldons J Lusis
Using mice to dissect genetic factors in atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(9):1501-9.
2003: Jesus A Araujo; Lingzhong Meng; Aaron D Tward; Wayne W Hancock; Yuan Zhai; Annie Lee; Kazunobu Ishikawa; Suhasini Iyer; Roland Buelow; Ronald W Busuttil; Diana M Shih; Aldons J Lusis; Jerzy W Kupiec-Weglinski
Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1572-80.
2003: Veronica V Colinayo; Jian-Hua Qiao; Xuping Wang; Kelly L Krass; Eric E Schadt; Aldons J Lusis; Thomas A Drake
Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2003;14(7):464-71.
2003: Kelly L Krass; Veronica V Colinayo; Anatole Ghazalpour; Harry V Vinters; Aldons J Lusis; Thomas A Drake
Genetic loci contributing to age-related hippocampal lesions in mice.
Neurobiology of disease 2003;13(2):102-8.
2003: Hooman Allayee; Lawrence W Castellani; Rita M Cantor; Tjerk W A de Bruin; Aldons J Lusis
Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia.
Circulation research 2003;92(11):1262-7.
2003: Toby B Cole; Rachel Jampsa; Betsy J Walter; Tara L Arndt; Rebecca J Richter; Diana M Shih; Aaron D Tward; Aldons J Lusis; Rhona M Jack; Lucio G Costa; Clement E Furlong
Expression of human paraoxonase (PON1) during development.
Pharmacogenetics 2003;13(6):357-64.
2003: Päivi Pajukanta; Hooman Allayee; Kelly L Krass; Ali Kuraishy; Aino Soro; Heidi E Lilja; Rebecca Mar; Marja-Riitta Taskinen; Ilpo Nuotio; Markku Laakso; Jerome I Rotter; Tjerk W A de Bruin; Rita M Cantor; Aldons J Lusis; Leena Peltonen
Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q.
American journal of human genetics 2003;72(4):903-17.
2003: Eric E Schadt; Stephanie A Monks; Thomas A Drake; Aldons J Lusis; Nam Che; Veronica V Colinayo; Thomas G Ruff; Stephen B Milligan; john lamb; Guy Cavet; Peter Linsley; Mao Mao; Roland B Stoughton; Stephen H Friend
Genetics of gene expression surveyed in maize, mouse and man.
Nature 2003;422(6929):297-302.
2003: Ichiro Nishimura; Thomas A Drake; Aldons J Lusis; Karen M Lyons; Joseph H Nadeau; Joseph Zernik
ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 2003;14(5):320-30.
2002: Jeffrey B. Smith; David J Wadleigh; Yu-Rong Xia; Rebecca A Mar; Harvey R Herschman; Aldons J Lusis
Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5.
Immunogenetics 2002;54(8):599-603.
2002: Alan D Attie; Ronald M Krauss; Mark P Gray-Keller; Alison Brownlie; Makoto Miyazaki; John J Kastelein; Aldons J Lusis; Anton F H Stalenhoef; Jonathan P Stoehr; Michael R Hayden; James M Ntambi
Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia.
Journal of lipid research 2002;43(11):1899-907.
2002: Desmond J Smith; Aldons J Lusis
The allelic structure of common disease.
Human molecular genetics 2002;11(20):2455-61.
2002: Rajendra K Tangirala; Eric D Bischoff; Sean B Joseph; Brandee L Wagner; Robert Walczak; Bryan A Laffitte; Chris L Daige; Diane Thomas; Richard A Heyman; David J Mangelsdorf; Xuping Wang; Aldons J Lusis; Peter Tontonoz; Ira G Schulman
Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11896-901.
2002: Margarete Mehrabian; Hooman Allayee; Jack Wong; Weibin Shi; Xu-Ping Wang; Zory Shaposhnik; Colin D Funk; Aldons J Lusis; Weibin Shih
Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice.
Circulation research 2002;91(2):120-6.
2002: Aaron D Tward; Yu-Rong Xia; Xu-Ping Wang; Yi-Shou Shi; Christina Park; Lawrence W Castellani; Aldons J Lusis; Diana M Shih
Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice.
Circulation 2002;106(4):484-90.
2002: Jason P Eiserich; Stephan Baldus; Marie-Luise Brennan; Wenxin Ma; Chunxiang Zhang; Albert Tousson; Laura Castro; Aldons J Lusis; William M Nauseef; C Roger White; Bruce Freeman
Myeloperoxidase, a leukocyte-derived vascular NO oxidase.
Science (New York, N.Y.) 2002;296(5577):2391-4.
2002: Veronica V Colinayo; Jian-Hua Qiao; Peter Demant; Kelly L Krass; Aldons J Lusis; Thomas A Drake
Genetic characterization of the Dyscalc locus.
Mammalian genome : official journal of the International Mammalian Genome Society 2002;13(6):283-8.
2002: Sean B Joseph; Elaine McKilligin; Liming Pei; Michael A Watson; Alan R Collins; Bryan A Laffitte; Mingyi Chen; Grace Noh; Joanne Goodman; Graham N Hagger; Jonathan Tran; Timothy K Tippin; Xuping Wang; Aldons J Lusis; Willa A Hsueh; Ronald E Law; Jon L Collins; Timothy M Willson; Peter Tontonoz
Synthetic LXR ligand inhibits the development of atherosclerosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7604-9.
2002: Marie-Luise Brennan; Weijia Wu; Xiaoming Fu; Zhongzhu Shen; Wei Song; Heather Frost; Caryn Vadseth; Laura Narine; Elizabeth Lenkiewicz; Michael T Borchers; Aldons J Lusis; James J Lee; Nancy A Lee; Husam M Abu-Soud; Harry Ischiropoulos; Stanley L Hazen
A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species.
The Journal of biological chemistry 2002;277(20):17415-27.
2002: Hooman Allayee; Kelly L Krass; Päivi Pajukanta; Rita M Cantor; Carla J H van der Kallen; Rebecca Mar; Jerome I Rotter; Tjerk W A de Bruin; Leena Peltonen; Aldons J Lusis
Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia.
Circulation research 2002;90(8):926-31.
2002: Weibin Shi; Xuping Wang; Diana M Shih; Victor E Laubach; Mohamad Navab; Aldons J Lusis
Paradoxical reduction of fatty streak formation in mice lacking endothelial nitric oxide synthase.
Circulation 2002;105(17):2078-82.
2002: Weibin Shi; Xuping Wang; Khan Tangchitpiyanond; Jack Wong; Yishou Shi; Aldons J Lusis
Atherosclerosis in C3H/HeJ mice reconstituted with apolipoprotein E-null bone marrow.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(4):650-5.
2002: Anna S Gukovskaya; Eva C Vaquero; Vjekoslav Zaninovic; Fred S Gorelick; Aldons J Lusis; Marie-Luise Brennan; Steven Holland; Stephen J Pandol
Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis.
Gastroenterology 2002;122(4):974-84.
2002: Sonal S Sheth; Andres Deluna; Hooman Allayee; Aldons J Lusis
Understanding atherosclerosis through mouse genetics.
Current opinion in lipidology 2002;13(2):181-9.
2002: Jon H Miyake; Xuandao T Duong-Polk; John M Taylor; Emma Z Du; Lawrence W Castellani; Aldons J Lusis; Roger A Davis
Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(1):121-6.
2002: Jackie S Bodnar; Aurobindo Chatterjee; Lawrence W Castellani; David A Ross; Jeffrey Ohmen; James Cavalcoli; Chenyan Wu; Katherine M Dains; Joe Catanese; Michael Chu; Sonal S Sheth; Kanti Charugundla; Peter Demant; David B West; Pieter de Jong; Aldons J Lusis
Positional cloning of the combined hyperlipidemia gene Hyplip1.
Nature genetics 2002;30(1):110-6.
2001: Stephan Baldus; Jason P Eiserich; A Mani; L Castro; Mario Figueroa; Phillip Chumley; W Ma; Albert Tousson; C Roger White; Daniel C Bullard; Marie-Luise Brennan; Aldons J Lusis; K P Moore; Bruce Freeman
Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration.
The Journal of clinical investigation 2001;108(12):1759-70.
2001: Hooman Allayee; Tjerk W A de Bruin; K Michelle Dominguez; L S Cheng; E Ipp; Rita M Cantor; Kelly L Krass; Eric T P Keulen; Bradley E Aouizerat; Aldons J Lusis; Jerome I Rotter
Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p.
Hypertension 2001;38(4):773-8.
2001: Margarete Mehrabian; Jack Wong; Xuping Wang; Z Jiang; Weibin Shi; Alan M Fogelman; Aldons J Lusis
Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia.
Circulation research 2001;89(2):125-30.
2001: M Karlsson; Karen Reue; Yu-Rong Xia; Aldons J Lusis; Dominique Langin; H Tornqvist; C Holm
Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene.
Gene 2001;272(1-2):11-8.
2001: O A Iakoubova; C L Olsson; Katherine M Dains; David A Ross; A Andalibi; K Lau; J Choi; I Kalcheva; M Cunanan; Judy Z Louie; V Nimon; M Machrus; L G Bentley; C Beauheim; S Silvey; James Cavalcoli; Aldons J Lusis; David B West
Genome-tagged mice (GTM): two sets of genome-wide congenic strains.
Genomics 2001;74(1):89-104.
2001: Thomas A Drake; Eric E Schadt; K Hannani; J Michael Kabo; Kelly L Krass; Veronica V Colinayo; Lloyd E Greaser; Jonathan G Goldin; Aldons J Lusis
Genetic loci determining bone density in mice with diet-induced atherosclerosis.
Physiological genomics 2001;5(4):205-15.
2001: Brian J Van Lenten; Mohamad Navab; Diana M Shih; Alan M Fogelman; Aldons J Lusis
The role of high-density lipoproteins in oxidation and inflammation.
Trends in cardiovascular medicine 2001;11(3-4):155-61.
2001: Srinivasa T Reddy; David J Wadleigh; Victor Grijalva; Carey Ng; Susan Hama; A Gangopadhyay; Diana M Shih; Aldons J Lusis; Mohamad Navab; Alan M Fogelman
Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(4):542-7.
2001: Mohamad Navab; Judith A Berliner; Ganesamoorthy Subbanagounder; Susan Hama; Aldons J Lusis; Lawrence W Castellani; Srinivasa Reddy; Diana M Shih; Weibin Shi; Andrew D Watson; Brian J Van Lenten; Devendra K Vora; Alan M Fogelman
HDL and the inflammatory response induced by LDL-derived oxidized phospholipids.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(4):481-8.
2001: Catherine C Hedrick; Lawrence W Castellani; Howard Wong; Aldons J Lusis
In vivo interactions of apoA-II, apoA-I, and hepatic lipase contributing to HDL structure and antiatherogenic functions.
Journal of lipid research 2001;42(4):563-70.
2001: Päivi Pajukanta; Jackie S Bodnar; Riitta Sallinen; M Chu; T Airaksinen; Q Xiao; Lawrence W Castellani; Sonal S Sheth; Maija Wessman; Aarno Palotie; Janet S Sinsheimer; Peter Demant; Aldons J Lusis; Leena Peltonen
Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL.
Mammalian genome : official journal of the International Mammalian Genome Society 2001;12(3):238-45.
2001: Lawrence W Castellani; A M Goto; Aldons J Lusis
Studies with apolipoprotein A-II transgenic mice indicate a role for HDLs in adiposity and insulin resistance.
Diabetes 2001;50(3):643-51.
2001: Marie-Luise Brennan; Martin M Anderson; D M Shih; XD Qu; Xuping Wang; A C Mehta; L L Lim; W Shi; Stanley L Hazen; J S Jacob; Jan R Crowley; Jay W Heinecke; Aldons J Lusis
Increased atherosclerosis in myeloperoxidase-deficient mice.
The Journal of clinical investigation 2001;107(4):419-30.
2000: Wan-Fen Li; Lucio G Costa; Rebecca J Richter; T Hagen; Diana M Shih; Aaron D Tward; Aldons J Lusis; Clement E Furlong
Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds.
Pharmacogenetics 2000;10(9):767-79.
2000: Hooman Allayee; Bryan A Laffitte; Aldons J Lusis
Biochemistry. An absorbing study of cholesterol.
Science (New York, N.Y.) 2000;290(5497):1709-11.
2000: Margarete Mehrabian; Lawrence W Castellani; Ping-Zi Wen; Jack Wong; T Rithaporn; Susan Hama; Greg Hough; D Johnson; J J Albers; Giuliano A Mottino; Joy S Frank; Mohamad Navab; Alan M Fogelman; Aldons J Lusis
Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J).
Journal of lipid research 2000;41(12):1936-46.
2000: Weibin Shi; Xuping Wang; Nicholas J Wang; william mcbride; Aldons J Lusis
Effect of macrophage-derived apolipoprotein E on established atherosclerosis in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(10):2261-6.
2000: Aldons J Lusis
Atherosclerosis.
Nature 2000;407(6801):233-41.
2000: Clement E Furlong; Wan-Fen Li; Victoria H Brophy; Gail P Jarvik; Rebecca J Richter; Diana M Shih; Aldons J Lusis; Lucio G Costa
The PON1 gene and detoxication.
Neurotoxicology 2000;21(4):581-7.
2000: Weibin Shi; Margaret Haberland; Ming-Len Jien; Diana M Shih; Aldons J Lusis
Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice.
Circulation 2000;102(1):75-81.
2000: Daniel P Widney; Yu-Rong Xia; Aldons J Lusis; Jeffrey B. Smith
The murine chemokine CXCL11 (IFN-inducible T cell alpha chemoattractant) is an IFN-gamma- and lipopolysaccharide-inducible glucocorticoid-attenuated response gene expressed in lung and other tissues during endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6322-31.
2000: Diana M Shih; Yu-Rong Xia; Xu-Ping Wang; E Miller; Lawrence W Castellani; Ganesamoorthy Subbanagounder; Hilde Cheroutre; Kym F Faull; Judith A Berliner; Joseph L Witztum; Aldons J Lusis
Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis.
The Journal of biological chemistry 2000;275(23):17527-35.
2000: Weibin Shi; Nicholas J Wang; Diana M Shih; V Z Sun; Xuping Wang; Aldons J Lusis
Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism.
Circulation research 2000;86(10):1078-84.
2000: A Mouzeyan; J Choi; Hooman Allayee; Xuping Wang; Janet S Sinsheimer; Jack Phan; Lawrence W Castellani; Karen Reue; Aldons J Lusis; Richard C Davis
A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2.
Journal of lipid research 2000;41(4):573-82.
2000: Clement E Furlong; Wan-Fen Li; Rebecca J Richter; Diana M Shih; Aldons J Lusis; E Alleva; Lucio G Costa
Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1).
Neurotoxicology 2000;21(1-2):91-100.
2000: Hooman Allayee; K M Dominguez; Bradley E Aouizerat; Ronald M Krauss; Jerome I Rotter; J Lu; Rita M Cantor; Tjerk W A de Bruin; Aldons J Lusis
Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia.
Journal of lipid research 2000;41(2):245-52.
1999: Bradley E Aouizerat; Hooman Allayee; Rita M Cantor; Geesje M Dallinga-Thie; CD Lanning; Tjerk W A de Bruin; Aldons J Lusis; Jerome I Rotter
Linkage of a candidate gene locus to familial combined hyperlipidemia: lecithin:cholesterol acyltransferase on 16q.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(11):2730-6.
1999: Bradley E Aouizerat; Hooman Allayee; Rita M Cantor; Richard C Davis; CD Lanning; Ping-Zi Wen; Geesje M Dallinga-Thie; Tjerk W A de Bruin; Jerome I Rotter; Aldons J Lusis
A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11.
American journal of human genetics 1999;65(2):397-412.
1999: Lucio G Costa; Wan-Fen Li; Rebecca J Richter; Diana M Shih; Aldons J Lusis; Clement E Furlong
The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism.
Chemico-biological interactions 1999;119-120():429-38.
1999: Norbert Leitinger; Andrew D Watson; Susan Hama; BT Ivandic; Jian-Hua Qiao; J Huber; Kym F Faull; David Grass; Mohamad Navab; Alan M Fogelman; Frederick C de Beer; Aldons J Lusis; Judith A Berliner
Role of group II secretory phospholipase A2 in atherosclerosis: 2. Potential involvement of biologically active oxidized phospholipids.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(5):1291-8.
1999: BT Ivandic; Lawrence W Castellani; Xu-Ping Wang; Jian-Hua Qiao; Margarete Mehrabian; Mohamad Navab; Alan M Fogelman; David Grass; M E Swanson; Maria C de Beer; Frederick C de Beer; Aldons J Lusis
Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(5):1284-90.
1999: Bradley E Aouizerat; Hooman Allayee; Jackie S Bodnar; Kelly L Krass; Leena Peltonen; Tjerk W A de Bruin; Jerome I Rotter; Aldons J Lusis
Novel genes for familial combined hyperlipidemia.
Current opinion in lipidology 1999;10(2):113-22.
1999: J L Escary; Henry A Choy; Karen Reue; X P Wang; Lawrence W Castellani; C K Glass; Aldons J Lusis; Michael C Schotz
Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages.
Journal of lipid research 1999;40(3):397-404.
1999: PT Shih; Marie-Luise Brennan; Devendra K Vora; Mary Territo; D Strahl; MJ Elices; Aldons J Lusis; Judith A Berliner
Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet.
Circulation research 1999;84(3):345-51.
1998: L Gu; A Weinreb; Xu-Ping Wang; Debra Zack; Jian-Hua Qiao; Richard H Weisbart; Aldons J Lusis
Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6999-7006.
1998: Clement E Furlong; Wan-Fen Li; Lucio G Costa; Rebecca J Richter; Diana M Shih; Aldons J Lusis
Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human PON1 polymorphism.
Neurotoxicology 1998;19(4-5):645-50.
1998: Hooman Allayee; Bradley E Aouizerat; Rita M Cantor; Geesje M Dallinga-Thie; Ronald M Krauss; CD Lanning; Jerome I Rotter; Aldons J Lusis; Tjerk W A de Bruin
Families with familial combined hyperlipidemia and families enriched for coronary artery disease share genetic determinants for the atherogenic lipoprotein phenotype.
American journal of human genetics 1998;63(2):577-85.
1998: Diana M Shih; L Gu; Yu-Rong Xia; Mohamad Navab; Wan-Fen Li; Susan Hama; Lawrence W Castellani; Clement E Furlong; Lucio G Costa; Alan M Fogelman; Aldons J Lusis
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis.
Nature 1998;394(6690):284-7.
1998: Tripathi B Rajavashisth; Jian-Hua Qiao; Subhash C Tripathi; J Tripathi; N Mishra; M Hua; Xu-Ping Wang; A Loussararian; S Clinton; P Libby; Aldons J Lusis
Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice.
The Journal of clinical investigation 1998;101(12):2702-10.
1998: Z Jiang; Diana M Shih; Yu-Rong Xia; Aldons J Lusis; Frederick C de Beer; Willem J S de Villiers; Deneys R van der Westhuyzen; Maria C de Beer
Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein.
Genomics 1998;50(2):199-205.
1998: Margarete Mehrabian; Ping-Zi Wen; Janis S Fisler; Richard C Davis; Aldons J Lusis
Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.
The Journal of clinical investigation 1998;101(11):2485-96.
1998: Lawrence W Castellani; A Weinreb; Jackie S Bodnar; A M Goto; Mark H Doolittle; Margarete Mehrabian; Peter Demant; Aldons J Lusis
Mapping a gene for combined hyperlipidaemia in a mutant mouse strain.
Nature genetics 1998;18(4):374-7.
1998: DE Tabor; Yu-Rong Xia; Margarete Mehrabian; Peter A Edwards; Aldons J Lusis
A cluster of stearoyl CoA desaturase genes, Scd1 and Scd2, on mouse chromosome 19.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(4):341-2.
1998: V Briquet-Laugier; Yu-Rong Xia; K Rooke; Margarete Mehrabian; Aldons J Lusis; Mark H Doolittle
Mapping of three members of the mouse protein disulfide isomerase family.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(2):176-7.
1998: Carrie L Welch; Yu-Rong Xia; Peter A Edwards; Aldons J Lusis; J Ericsson
Assignment of Gpam to distal mouse chromosome 19 by linkage analysis.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(1):93.
1997: Carrie L Welch; Yu-Rong Xia; L J Gu; D Machleder; Margarete Mehrabian; Ping-Zi Wen; N Webb; Willem J S de Villiers; Deneys R van der Westhuyzen; Aldons J Lusis
Srb1 maps to mouse chromosome 5 in a region harboring putative QTLs for plasma lipoprotein levels.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(12):942-4.
1997: A I Fyfe; LS Rothenberg; F C DeBeer; R M Cantor; Jerome I Rotter; Aldons J Lusis
Association between serum amyloid A proteins and coronary artery disease: evidence from two distinct arteriosclerotic processes.
Circulation 1997;96(9):2914-9.
1997: Frederick C de Beer; Maria C de Beer; Deneys R van der Westhuyzen; Lawrence W Castellani; Aldons J Lusis; M E Swanson; David Grass
Secretory non-pancreatic phospholipase A2: influence on lipoprotein metabolism.
Journal of lipid research 1997;38(11):2232-9.
1997: Martin Klingenspor; J Bodnar; C Welch; Yu-Rong Xia; Aldons J Lusis; Karen Reue
Localization of ubiquitin gene family members to mouse chromosomes 5, 11, and 18.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(10):789-90.
1997: A V Lembertas; L Pérusse; Y C Chagnon; Janis S Fisler; Craig H Warden; D A Purcell-Huynh; FT Dionne; J Gagnon; A Nadeau; Aldons J Lusis; Claude Bouchard
Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.
The Journal of clinical investigation 1997;100(5):1240-7.
1997: K Ishikawa; Mohamad Navab; Norbert Leitinger; Alan M Fogelman; Aldons J Lusis
Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL.
The Journal of clinical investigation 1997;100(5):1209-16.
1997: Carrie L Welch; Yu-Rong Xia; H Hong; M R Stallcup; Aldons J Lusis
Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(8):620-1.
1997: Lawrence W Castellani; Mohamad Navab; Brian J Van Lenten; Catherine C Hedrick; Susan Hama; A M Goto; Alan M Fogelman; Aldons J Lusis
Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles.
The Journal of clinical investigation 1997;100(2):464-74.
1997: Martin Klingenspor; J Bodnar; Yu-Rong Xia; C Welch; Aldons J Lusis; Karen Reue
Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs) to mouse chromosomes 11 and 15 respectively.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(7):539-40.
1997: Jian-Hua Qiao; J Tripathi; N K Mishra; Y Cai; Subhash C Tripathi; Xu-Ping Wang; S Imes; Michael C Fishbein; S K Clinton; P Libby; Aldons J Lusis; Tripathi B Rajavashisth
Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice.
The American journal of pathology 1997;150(5):1687-99.
1997: Mohamad Navab; S Hama-Levy; Brian J Van Lenten; Gregg C Fonarow; C J Cardinez; Lawrence W Castellani; Marie-Luise Brennan; Aldons J Lusis; Alan M Fogelman; Bert N La Du
Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.
The Journal of clinical investigation 1997;99(8):2005-19.
1997: R D Cohen; Lawrence W Castellani; Jian-Hua Qiao; Brian J Van Lenten; Aldons J Lusis; Karen Reue
Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV.
The Journal of clinical investigation 1997;99(8):1906-16.
1997: D Machleder; BT Ivandic; C Welch; Lawrence W Castellani; Karen Reue; Aldons J Lusis
Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism.
The Journal of clinical investigation 1997;99(6):1406-19.
1997: K Rooke; V Briquet-Laugier; Yu-Rong Xia; Aldons J Lusis; Mark H Doolittle
Mapping of the gene for calreticulin (Calr) to mouse chromosome 8.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(11):870-1.
1993: Aldons J Lusis
The mouse model for atherosclerosis.
Trends in cardiovascular medicine 1993;3(4):135-43.