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Thomas Luther

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Bettina Grismayer; Charlotte Kopitz; Matthias Kotzsch; Achim Krüger; Thomas Luther; Christian Ries; Sumito Sato; Manfred Schmitt; Susanne Soelch; Gustavo Baretton; Viktor Magdolen
Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes.
Bettina Grismayer; Thomas Kirchner; Matthias Kotzsch; Achim Krüger; Thomas Luther; Sonja Schäfer; Manfred Schmitt; Bastian Seubert; Susanne Sölch; Gustavo Baretton; Viktor Magdolen
Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells.
Sumito Sato; Charlotte Kopitz; Bettina Grismayer; Nathalie Beaufort; Ute Reuning; Manfred Schmitt; Thomas Luther; Matthias Kotzsch; Achim Krüger; Viktor Magdolen
Overexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo.

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2012: Bettina Grismayer; Charlotte Kopitz; Matthias Kotzsch; Achim Krüger; Thomas Luther; Christian Ries; Sumito Sato; Manfred Schmitt; Susanne Soelch; Gustavo Baretton; Viktor Magdolen
Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes.
Biological chemistry 2012;393(12):1449-55.
2012: Bettina Grismayer; Thomas Kirchner; Matthias Kotzsch; Achim Krüger; Thomas Luther; Sonja Schäfer; Manfred Schmitt; Bastian Seubert; Susanne Sölch; Gustavo Baretton; Viktor Magdolen
Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells.
Molecular cancer 2012;11():62.
2011: Sumito Sato; Charlotte Kopitz; Bettina Grismayer; Nathalie Beaufort; Ute Reuning; Manfred Schmitt; Thomas Luther; Matthias Kotzsch; Achim Krüger; Viktor Magdolen
Overexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo.
Breast cancer research and treatment 2011;127(3):649-57.
2011: Marianne Grosser; Viktor Magdolen; Gustavo Baretton; Thomas Luther; Sybille Albrecht
Gene expression analysis of HUVEC in response to TF-binding.
Thrombosis research 2011;127(3):259-63.
2011: Matthias Kotzsch; Christine Lautenschläger; Thomas Luther; Viktor Magdolen; Matthias Bache; Gustavo Baretton; Alexander W Eckert; Susanne Füssel; T Greither; Matthias Kappler; Peter Würl; Helge Taubert
Combined mRNA expression levels of members of the urokinase plasminogen activator (uPA) system correlate with disease-associated survival of soft-tissue sarcoma patients.
BMC cancer 2011;11():273.
2010: Matthias Kotzsch; Katharina Bernt; Katrin Friedrich; Elvira Luther; Sybille Albrecht; Axel Gatzweiler; Viktor Magdolen; Gustavo B Baretton; Christian Zietz; Thomas Luther
Prognostic relevance of tumour cell-associated uPAR expression in invasive ductal breast carcinoma.
Histopathology 2010;57(3):461-71.
2010: Rafal Pawlinski; Jian-Guo Wang; A Phillip Owens; Julie Williams; Silvio Antoniak; Michael Tencati; Thomas Luther; Jesse W Rowley; Elizabeth N Low; Andrew S Weyrich; Nigel Mackman
Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice.
Blood 2010;116(5):806-14.
2008: Matthias Kotzsch; Anieta M Sieuwerts; Marianne Grosser; Axel Meye; Susanne Fuessel; Marion E Meijer-Van Gelder; Marcel Smid; Manfred Schmitt; Gustavo Baretton; Thomas Luther; Viktor Magdolen; John A Foekens
Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer: identification of rab31 as an independent prognostic factor.
Breast cancer research and treatment 2008;111(2):229-40.
2008: Julia C Biermann; Leon Holzscheiter; Matthias Kotzsch; Thomas Luther; Marion Kiechle-Bahat; Fred C G J Sweep; Paul Span; Manfred Schmitt; Viktor Magdolen
Quantitative RT-PCR assays for the determination of urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 mRNA in primary tumor tissue of breast cancer patients: comparison to antigen quantification by ELISA.
International journal of molecular medicine 2008;21(2):251-9.
2007: Rafal Pawlinski; Michael Tencati; Craig R Hampton; Tetsuro Shishido; Tara A Bullard; Liam M Casey; Patricia Andrade-Gordon; Matthias Kotzsch; Denise J Spring; Thomas Luther; Jun-ichi Abe; Timothy H Pohlman; Edward D Verrier; Burns C Blaxall; Nigel Mackman
Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy.
Circulation 2007;116(20):2298-306.
2006: Leon Holzscheiter; Julia C Biermann; Matthias Kotzsch; Panagiotis Prezas; Juliane Farthmann; Gustavo B Baretton; Thomas Luther; Vivianne C G Tjan-Heijnen; Maroulio Talieri; Manfred Schmitt; Fred C G J Sweep; Paul Span; Viktor Magdolen
Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer.
Clinical chemistry 2006;52(6):1070-9.
2005: Matthias Kotzsch; Juliane Farthmann; Axel Meye; Susanne Fuessel; Gustavo B Baretton; Vivianne C G Tjan-Heijnen; Manfred Schmitt; Thomas Luther; Fred C G J Sweep; Viktor Magdolen; Paul Span
Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer.
European journal of cancer (Oxford, England : 1990) 2005;41(17):2760-8.
2005: Jiang Chen; Michael Kasper; Tobias Heck; Katsumi Nakagawa; Per M Humpert; Ling Bai; Gang Wu; Youming Zhang; Thomas Luther; Martin Andrassy; Stephan Schiekofer; Andreas Hamann; Michael Morcos; Baoshen Chen; David M Stern; Peter P Nawroth; Angelika Bierhaus
Tissue factor as a link between wounding and tissue repair.
Diabetes 2005;54(7):2143-54.
2005: Marianne Grosser; Thomas Luther; Monika Fuessel; Jakob Bickhardt; Viktor Magdolen; Gustavo B Baretton
Clinical course of sarcoidosis in dependence on HLA-DRB1 allele frequencies, inflammatory markers, and the presence of M. tuberculosis DNA fragments.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 2005;22(1):66-74.
2004: Bernd Werle; Matthias Kotzsch; Tamara T Lah; Janko Kos; D Gabrijelcic-Geiger; Eberhard Spiess; J Schirren; Werner Ebert; Werner Fiehn; Thomas Luther; V Magdolen; Manfred Schmitt; N Harbeck
Cathepsin B, plasminogenactivator-inhibitor (PAI-1) and plasminogenactivator-receptor (uPAR) are prognostic factors for patients with non-small cell lung cancer.
Anticancer research 2004;24(6):4147-61.
2004: Dirk Haufe; Thomas Luther; Matthias Kotzsch; Lilla Knels; Thea Koch
Perfluorocarbon attenuates response of concanavalin A-stimulated mononuclear blood cells without altering ligand-receptor interaction.
American journal of physiology. Lung cellular and molecular physiology 2004;287(1):L210-6.
2003: Thomas Luther; Matthias Kotzsch; Axel Meye; Thomaz Langerholc; Susanne Füssel; Natalie Olbricht; Sybille Albrecht; Detlef Ockert; Bernd Muehlenweg; Katrin Friedrich; Marianne Grosser; Manfred Schmitt; Gustavo B Baretton; Viktor Magdolen
Identification of a novel urokinase receptor splice variant and its prognostic relevance in breast cancer.
Thrombosis and haemostasis 2003;89(4):705-17.
2003: Ingrid Müller; Antje Klocke; Meike Alex; Matthias Kotzsch; Thomas Luther; Eberhard Morgenstern; Susanne Zieseniss; Stefan Zahler; Klaus Preissner; Bernd Engelmann
Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(3):476-8.
2003: Bernd Engelmann; Thomas Luther; Ingrid Müller
Intravascular tissue factor pathway--a model for rapid initiation of coagulation within the blood vessel.
Thrombosis and haemostasis 2003;89(1):3-8.
2002: Sybille Albrecht; Viktor Magdolen; Ute Herzog; Lindsey Miles; Angela Kirschenhofer; Gustavo B Baretton; Thomas Luther
Soluble tissue actor interferes with angiostatin-mediated inhibition of endothelial cell proliferation by lysine-specific interaction with plasminogen kringle domains.
Thrombosis and haemostasis 2002;88(6):1054-9.
2002: Rafal Pawlinski; A Fernandes; Bettina Kehrle; Brian Pedersen; G Parry; Jonathan Erlich; Robert T Pyo; D Gutstein; J Zhang; F Castellino; Els Melis; Peter Carmeliet; G Baretton; Thomas Luther; M Taubman; E Rosen; Nigel Mackman
Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15333-8.
2001: Angelika Bierhaus; Stephan Schiekofer; Markus Schwaninger; Martin Andrassy; Per M Humpert; Jiang Chen; M Hong; Thomas Luther; Thomas Henle; I Klöting; Michael Morcos; Michael Hofmann; Hans Tritschler; B Weigle; Michael Kasper; Mark A. Smith; George Perry; Ann Marie Schmidt; David M Stern; Hans-Ulrich Häring; Erwin Schleicher; Peter P Nawroth
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.
Diabetes 2001;50(12):2792-808.
2001: Verena Lutz; Ute Reuning; Achim Krüger; Thomas Luther; S P von Steinburg; Henner Graeff; Manfred Schmitt; Olaf G Wilhelm; Viktor Magdolen
High level synthesis of recombinant soluble urokinase receptor (CD87) by ovarian cancer cells reduces intraperitoneal tumor growth and spread in nude mice.
Biological chemistry 2001;382(5):789-98.
2001: Wolfgang Schwab; Johann Marian Gavlik; T Beichler; Richard H W Funk; S Albrecht; Viktor Magdolen; Thomas Luther; Michael Kasper; Mehdi Shakibaei
Expression of the urokinase-type plasminogen activator receptor in human articular chondrocytes: association with caveolin and beta 1-integrin.
Histochemistry and cell biology 2001;115(4):317-23.
2001: Marianne Grosser; Dag-Daniel Dittert; Thomas Luther
Re: Molecular detection of M. tuberculosis DNA in tuberculosis and sarcoidosis.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2001;10(1):66-8.
2001: A Zillmann; Thomas Luther; Ingrid Müller; Matthias Kotzsch; Michael Spannagl; T Kauke; U Oelschlägel; Stefan Zahler; Bernd Engelmann
Platelet-associated tissue factor contributes to the collagen-triggered activation of blood coagulation.
Biochemical and biophysical research communications 2001;281(2):603-9.
2001: Thea Koch; Maximilian Ragaller; D Haufe ; Anna Hofer; Marianne Grosser; Detlev Michael Albrecht; Matthias Kotzsch; Thomas Luther
Perfluorohexane attenuates proinflammatory and procoagulatory response of activated monocytes and alveolar macrophages.
Anesthesiology 2001;94(1):101-9.
2000: Jonathan Erlich; E M Boyle; J Labriola; JC Kovacich; Richard A Santucci; Colleen Fearns; Elizabeth N Morgan; W Yun; Thomas Luther; O Kojikawa; T R Martin; Timothy H Pohlman; Edward D Verrier; Nigel Mackman
Inhibition of the tissue factor-thrombin pathway limits infarct size after myocardial ischemia-reperfusion injury by reducing inflammation.
The American journal of pathology 2000;157(6):1849-62.
2000: Matthias Kotzsch; Thomas Luther; Nadia Harbeck; Detlef Ockert; Verena Lutz; Frank Noack; D Grossmann; Sybille Albrecht; Michael D Kramer; A Lossnitzer; Marianne Grosser; Manfred Schmitt; Viktor Magdolen
New ELISA for quantitation of human urokinase receptor (CD87) in cancer.
International journal of oncology 2000;17(4):827-34.
2000: Thomas Luther; Dag-Daniel Dittert; Matthias Kotzsch; Jonathan Erlich; Sybille Albrecht; Nigel Mackman; M Müller
Functional implications of tissue factor localization to cell-cell contacts in myocardium.
The Journal of pathology 2000;192(1):121-30.
2000: Viktor Magdolen; Nuria Arroyo De Prada; Stefan Sperl; Bernd Muehlenweg; Thomas Luther; Olaf G Wilhelm; Ulla Magdolen; Henner Graeff; Ute Reuning; Manfred Schmitt
Natural and synthetic inhibitors of the tumor-associated serine protease urokinase-type plasminogen activator.
Advances in experimental medicine and biology 2000;477():331-41.
1999: Jonathan Erlich; Graham C Parry; Colleen Fearns; M Muller; Peter Carmeliet; Thomas Luther; Nigel Mackman
Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8138-43.
1999: Marianne Grosser; Thomas Luther; J Müller; M Schuppler; Jakob Bickhardt; W Matthiessen; M Müller
Detection of M. tuberculosis DNA in sarcoidosis: correlation with T-cell response.
Laboratory investigation; a journal of technical methods and pathology 1999;79(7):775-84.
1999: M Müller; Sybille Albrecht; F Gölfert; A Hofer; Richard H W Funk; Viktor Magdolen; C Flössel; Thomas Luther
Localization of tissue factor in actin-filament-rich membrane areas of epithelial cells.
Experimental cell research 1999;248(1):136-47.
1998: K Fischer; Verena Lutz; Olaf G Wilhelm; Manfred Schmitt; Henner Graeff; P Heiss; T Nishiguchi; Nadia Harbeck; Horst Kessler; Thomas Luther; Viktor Magdolen; Ute Reuning
Urokinase induces proliferation of human ovarian cancer cells: characterization of structural elements required for growth factor function.
FEBS letters 1998;438(1-2):101-5.
1998: Viktor Magdolen; Sybille Albrecht; Matthias Kotzsch; C Haller; Markus Bürgle; Uwe Jacob; Marianne Grosser; Horst Kessler; Henner Graeff; M Müller; Manfred Schmitt; Thomas Luther
Immunological and functional analyses of the extracellular domain of human tissue factor.
Biological chemistry 1998;379(2):157-65.
1998: Graham C Parry; Jonathan Erlich; Peter Carmeliet; Thomas Luther; Nigel Mackman
Low levels of tissue factor are compatible with development and hemostasis in mice.
The Journal of clinical investigation 1998;101(3):560-9.
1997: Franz-Josef Neumann; Ilka Ott; N Marx; Thomas Luther; S Kenngott; Meinrad Gawaz; Matthias Kotzsch; A Schömig
Effect of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(12):3399-405.
1997: Angelika Bierhaus; Thomas Illmer; Michael Kasper; Thomas Luther; Peter Quehenberger; Hans Tritschler; P Wahl; Reinhard Ziegler; M Müller; Peter P Nawroth
Advanced glycation end product (AGE)-mediated induction of tissue factor in cultured endothelial cells is dependent on RAGE.
Circulation 1997;96(7):2262-71.
1997: Angelika Bierhaus; S Chevion; Mordechai Chevion; Michael Hofmann; Peter Quehenberger; Thomas Illmer; Thomas Luther; E Berentshtein; Hans Tritschler; M Müller; P Wahl; Reinhard Ziegler; Peter P Nawroth
Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells.
Diabetes 1997;46(9):1481-90.
1997: Angelika Bierhaus; Youming Zhang; Peter Quehenberger; Thomas Luther; M Haase; M Müller; Nigel Mackman; Reinhard Ziegler; Peter P Nawroth
The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B.
Thrombosis and haemostasis 1997;77(4):772-82.
1997: Thomas Luther; Viktor Magdolen; Sybille Albrecht; M Kasper; C Riemer; Horst Kessler; Henner Graeff; M Müller; Manfred Schmitt
Epitope-mapped monoclonal antibodies as tools for functional and morphological analyses of the human urokinase receptor in tumor tissue.
The American journal of pathology 1997;150(4):1231-44.
1997: MS Zumbach; Michael Hofmann; V Borcea; Thomas Luther; Matthias Kotzsch; M Müller; Olaf Hergesell; Konrad Andrassy; Eberhard Ritz; Reinhard Ziegler; P Wahl; Peter P Nawroth
Tissue factor antigen is elevated in patients with microvascular complications of diabetes mellitus.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1997;105(4):206-12.
1996: Peter Carmeliet; Nigel Mackman; Lieve Moons; Thomas Luther; P Gressens; I Van Vlaenderen; H Demunck; M Kasper; G Breier; P Evrard; M Müller; W Risau; T Edgington; Désiré Collen
Role of tissue factor in embryonic blood vessel development.
Nature 1996;383(6595):73-5.
1996: Thomas Luther; C Flössel; Nigel Mackman; Angelika Bierhaus; Michael Kasper; Sybille Albrecht; E Helene Sage; L Iruela-Arispe; H Grossmann; A Ströhlein; Youming Zhang; Peter P Nawroth; Peter Carmeliet; D J Loskutoff; M Müller
Tissue factor expression during human and mouse development.
The American journal of pathology 1996;149(1):101-13.
1996: Sybille Albrecht; Matthias Kotzsch; Gabriele Siegert; Thomas Luther; H Grossmann; Marianne Grosser; M Müller
Detection of circulating tissue factor and factor VII in a normal population.
Thrombosis and haemostasis 1996;75(5):772-7.
1996: Thomas Luther; C Flössel; Sybille Albrecht; Matthias Kotzsch; M Müller
Tissue factor expression in normal and abnormal mammary gland.
Nature medicine 1996;2(5):491-2.
1995: Angelika Bierhaus; Youming Zhang; Y Deng; Nigel Mackman; Peter Quehenberger; M Haase; Thomas Luther; M Müller; H Böhrer; J Greten
Mechanism of the tumor necrosis factor alpha-mediated induction of endothelial tissue factor.
The Journal of biological chemistry 1995;270(44):26419-32.
1995: Michael Kasper; Roland Koslowski; Thomas Luther; D Schuh; M Müller; Klaus-Wolfgang Wenzel
Immunohistochemical evidence for loss of ICAM-1 by alveolar epithelial cells in pulmonary fibrosis.
Histochemistry and cell biology 1995;104(5):397-405.
1995: T Wendt; Y M Zhang; Angelika Bierhaus; J Kriegsmann; Y Deng; R Waldherr; T Teske; Thomas Luther; Reinhard Fünfstück; Peter P Nawroth
Tissue factor expression in an animal model of hydronephrosis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995;10(10):1820-8.
1995: Sybille Albrecht; S Müller; Gabriele Siegert; Thomas Luther; M Müller
Plasma concentration of tissue factor and factor VII in patients after abdominal surgery.
Thrombosis research 1995;77(6):557-62.
1994: Youming Zhang; Y Deng; Thomas Luther; M Müller; Reinhard Ziegler; R Waldherr; David M Stern; Peter P Nawroth
Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice.
The Journal of clinical investigation 1994;94(3):1320-7.
1994: C Flössel; Thomas Luther; M Müller; Sybille Albrecht; Michael Kasper
Immunohistochemical detection of tissue factor (TF) on paraffin sections of routinely fixed human tissue.
Histochemistry 1994;101(6):449-53.
1993: M Müller; C Flössel; M Haase; Thomas Luther; Sybille Albrecht; Peter P Nawroth; Youming Zhang
Cellular localization of tissue factor in human breast cancer cell lines.
Virchows Archiv. B, Cell pathology including molecular pathology 1993;64(5):265-9.
1992: Sybille Albrecht; Thomas Luther; H Grossmann; C Flössel; Matthias Kotzsch; M Müller
An ELISA for tissue factor using monoclonal antibodies.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1992;3(3):263-70.
1992: U Sturm; Thomas Luther; Sybille Albrecht; C Flössel; H Grossmann; M Müller
Immunohistological detection of tissue factor in normal and abnormal human mammary glands using monoclonal antibodies.
Virchows Archiv. A, Pathological anatomy and histopathology 1992;421(2):79-86.
1992: C Flössel; Thomas Luther; Sybille Albrecht; Matthias Kotzsch; M Müller
Constitutive tissue factor expression of human breast cancer cell line MCF-7 is modulated by growth factors.
European journal of cancer (Oxford, England : 1990) 1992;28A(12):1999-2002.
1990: Thomas Luther; C Flössel; V Hietschhold; Roland Koslowski; M Müller
Flow cytometric analysis of tissue factor (TF) expression on stimulated monocytes--comparison to procoagulant activity of mononuclear blood cells.
Blut 1990;61(6):375-8.