FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Ruth Luthi-Carter

Research Profile

Disorders

Chemicals & Drugs

Living Beings

Anatomy

Procedures

Gene Expression Profiling

Devices

Oligonucleotide Array Sequence Analysis

Physiology

Co-author Network

Publications

TOP 3
Ana Jovičić; Nicoleta Moisoi; Roger Moser; Beena Pillai; Sylvain Pradervand; Reema Roshan; Ruth Luthi-Carter
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.
David M Taylor; Roger Moser; Etienne Régulier; Mariana de Fatima Silva Santos; Ayshe Ana Beesen; Lionel Breuillaud; Meredith Dixon; Linda Elliston; Robert J Ferrante; Darlene R Goldstein; Lesley Jones; Jinho Kim; Ruth Luthi-Carter
MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition.
Ana Jovicic; Roger Moser; Mariana de Fatima Silva Santos; Julien Francisco Zaldivar Jolissaint; Ruth Luthi-Carter
MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Ruth Luthi-Carter (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Ana Jovičić; Nicoleta Moisoi; Roger Moser; Beena Pillai; Sylvain Pradervand; Reema Roshan; Ruth Luthi-Carter
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(12):5127-37.
2013: David M Taylor; Roger Moser; Etienne Régulier; Mariana de Fatima Silva Santos; Ayshe Ana Beesen; Lionel Breuillaud; Meredith Dixon; Linda Elliston; Robert J Ferrante; Darlene R Goldstein; Lesley Jones; Jinho Kim; Ruth Luthi-Carter
MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(6):2313-25.
2013: Ana Jovicic; Roger Moser; Mariana de Fatima Silva Santos; Julien Francisco Zaldivar Jolissaint; Ruth Luthi-Carter
MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms.
PloS one 2013;8(1):e54222.
2013: Abdelwahed Chtarto; Ralph Clinkers; Olivier De Witte; Elias Gebara; Marc Levivier; Ruth Luthi-Carter; C Melas; Catherine Pythoud; Olivier Bockstael; Katia Vermoesen; Liliane Tenenbaum
An adeno-associated virus-based intracellular sensor of pathological nuclear factor-κB activation for disease-inducible gene transfer.
PloS one 2013;8(1):e53156.
2012: Bernd Friedrich; Sabine Hellwig; Alexandre Kuhn; Bernhard G Landwehrmeyer; Ruth Luthi-Carter; Cornelius Weiller; Ruhtraut Ziegler; Philipp Euler; Birgit Zucker
Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases.
Brain research 2012;1481():37-48.
2012: Karen N McFarland; Ghazaleh Sadri-Vakili; Gavin R Sangrey; Ting Ting Sun; Eva Xia; Timothy W Clark; Sudeshna Das; Alexandre Kuhn; Dmitri Leyfer; Ruth Luthi-Carter; Jang-Ho J Cha
Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.
PloS one 2012;7(7):e41423.
2012: Tamara Seredenina; Ruth Luthi-Carter
What have we learned from gene expression profiles in Huntington's disease?
Neurobiology of disease 2012;45(1):83-98.
2011: Alexandre Kuhn; Doris Thu; Henry J Waldvogel; Richard L M Faull; Ruth Luthi-Carter
Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain.
Nature methods 2011;8(11):945-7.
2011: Markus Bonda; László Forró; Ariane Kretlow; Ruth Luthi-Carter; Lisa M Miller; Valérie Perrin; Heike Runne; Bertrand Vileno; Sylvia Jeney
Synchrotron infrared microspectroscopy detecting the evolution of Huntington's disease neuropathology and suggesting unique correlates of dysfunction in white versus gray brain matter.
Analytical chemistry 2011;83(20):7712-20.
2011: David M Taylor; Ben Woodman; Zhongmin Xiang; Allison Amore; Uma Balabadra; Gillian P Bates; Philip A S Lowden; Ruth Luthi-Carter; Michele M Maxwell; Sarah Meade; Steven Reeves; Aleksey G Kazantsev
A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase.
ACS chemical biology 2011;6(6):540-6.
2011: Bin Tang; Tamara Seredenina; Giovanni Coppola; Alexandre Kuhn; Daniel Geschwind; Ruth Luthi-Carter; Elizabeth A Thomas
Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease.
Neurobiology of disease 2011;42(3):459-67.
2011: Elizabeth A Thomas; Giovanni Coppola; Bin Tang; Alexandre Kuhn; SoongHo Kim; Daniel Geschwind; Timothy B Brown; Ruth Luthi-Carter; Michelle E Ehrlich
In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.
Human molecular genetics 2011;20(6):1049-60.
2011: Tamara Seredenina; Ozgun Gokce; Ruth Luthi-Carter
Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation.
PloS one 2011;6(7):e22231.
2010: Luca Gambazzi; Ozgun Gokce; Tamara Seredenina; Elena Katsyuba; Heike Runne; Henry Markram; Michele Giugliano; Ruth Luthi-Carter
Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments.
The Journal of pharmacology and experimental therapeutics 2010;335(1):13-22.
2010: Birgit Zucker; Jibrin A Kama; Alexandre Kuhn; Doris Thu; Lianna R Orlando; Anthone W Dunah; Ozgun Gokce; David M Taylor; Johann Lambeck; Bernd Friedrich; Katrin S Lindenberg; Richard L M Faull; Cornelius Weiller; Anne B Young; Ruth Luthi-Carter
Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease.
Journal of neuropathology and experimental neurology 2010;69(9):880-95.
2010: Caroline L Benn; Ruth Luthi-Carter; Alexandre Kuhn; Ghazaleh Sadri-Vakili; Kwabena L Blankson; Sudeb C Dalai; Darlene R Goldstein; Tara L Spires; Joel Pritchard; James M Olson; Anton van Dellen; Anthony J Hannan; Jang-Ho J Cha
Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease.
Journal of neuropathology and experimental neurology 2010;69(8):817-27.
2010: Le Xiao; Yunyun Han; Heike Runne; Heather Murray; Olexiy Kochubey; Ruth Luthi-Carter; Ralf Schneggenburger
Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons.
Molecular and cellular neurosciences 2010;44(4):374-85.
2010: Fang Wu; Claude Schweizer; Nikita Rudinskiy; David M Taylor; Aleksey Kazantsev; Ruth Luthi-Carter; Patrick C Fraering
Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(7):2464-74.
2010: Ruth Luthi-Carter; David M Taylor; Judit Pallos; Emmanuel Lambert; Allison Amore; Alex Parker; Hilary Moffitt; Donna L Smith; Heike Runne; Ozgun Gokce; Alexandre Kuhn; Zhongmin Xiang; Michele M Maxwell; Steven A Reeves; Gillian P Bates; Christian Neri; Leslie M Thompson; J Lawrence Marsh; Aleksey G Kazantsev
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(17):7927-32.
2010: Kristina Becanovic; Mahmoud A Pouladi; Raymond S Lim; Alexandre Kuhn; Paul Pavlidis; Ruth Luthi-Carter; Michael R Hayden; Blair R Leavitt
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis.
Human molecular genetics 2010;19(8):1438-52.
2010: Doris C V Thu; Dorothy E Oorschot; Lynette J Tippett; Alissa L Nana; Virginia M Hogg; Beth Synek; Ruth Luthi-Carter; Henry J Waldvogel; Richard L M Faull
Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease.
Brain : a journal of neurology 2010;133(Pt 4):1094-110.
2010: Gelareh Mazarei; Scott J Neal; Kristina Becanovic; Ruth Luthi-Carter; Elizabeth M Simpson; Blair R Leavitt
Expression analysis of novel striatal-enriched genes in Huntington disease.
Human molecular genetics 2010;19(4):609-22.
2009: Nikita Rudinskiy; Yoshio A Kaneko; Ayshe Ana Beesen; Ozgun Gokce; Etienne Régulier; Nicole Deglon; Ruth Luthi-Carter
Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons.
Journal of neurochemistry 2009;111(2):460-72.
2009: Nikita Rudinskiy; Yulia Grishchuk; Anne Vaslin; Julien Puyal; André Delacourte; Harald Hirling; Peter G H Clarke; Ruth Luthi-Carter
Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration.
The Journal of biological chemistry 2009;284(18):12447-58.
2009: Zabel Claus; Lei Mao; Ben Woodman; Michael Rohe; Maik A Wacker; Yvonne Kläre; Andrea Koppelstätter; Grit Nebrich; Oliver Klein; Susanne Grams; Andrew Strand; Ruth Luthi-Carter; Daniela Hartl; Joachim Klose; Gillian P Bates
A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease.
Molecular & cellular proteomics : MCP 2009;8(4):720-34.
2009: Valérie Drouet; Valérie Perrin; Raymonde Hassig; Noëlle Dufour; Gwennaelle Auregan; Sandro Alves; Gilles Bonvento; Emmanuel Brouillet; Ruth Luthi-Carter; Philippe Hantraye; Nicole Deglon
Sustained effects of nonallele-specific Huntingtin silencing.
Annals of neurology 2009;65(3):276-85.
2009: Ozgun Gokce; Heike Runne; Alexandre Kuhn; Ruth Luthi-Carter
Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation.
PloS one 2009;4(4):e5292.
2008: Asad Jan; Ozgun Gokce; Ruth Luthi-Carter; Hilal A Lashuel
The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.
The Journal of biological chemistry 2008;283(42):28176-89.
2008: Heike Runne; Etienne Régulier; Alexandre Kuhn; Diana Zala; Ozgun Gokce; Valérie Perrin; Beate Sick; Patrick Aebischer; Nicole Deglon; Ruth Luthi-Carter
Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(39):9723-31.
2008: Susan Willi-Monnerat; Eugenia Migliavacca; Didier Surdez; Mauro Delorenzi; Ruth Luthi-Carter; Alexey V Terskikh
Comprehensive spatiotemporal transcriptomic analyses of the ganglionic eminences demonstrate the uniqueness of its caudal subdivision.
Molecular and cellular neurosciences 2008;37(4):845-56.
2008: Alexandre Kuhn; Ruth Luthi-Carter; Mauro Delorenzi
Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'.
BMC bioinformatics 2008;9():26.
2008: Delphine Charvin; Emmanuel Roze; Valérie Perrin; Carole Deyts; Sandrine Betuing; Christiane Pagès; Etienne Régulier; Ruth Luthi-Carter; Emmanuel Brouillet; Nicole Deglon; Jocelyne Caboche
Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo.
Neurobiology of disease 2008;29(1):22-9.
2007: Edward C Stack; Alpaslan Dedeoglu; Karen M Smith; Kerry Cormier; James K Kubilus; Mikhail B Bogdanov; Wayne R Matson; Lichuan Yang; Bruce G Jenkins; Ruth Luthi-Carter; Neil W Kowall; Steven M Hersch; M Flint Beal; Robert J Ferrante
Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(47):12908-15.
2007: Heike Runne; Alexandre Kuhn; Edward J Wild; Wirahpati Pratyaksha; Mark Kristiansen; Jeremy D Isaacs; Etienne Régulier; Mauro Delorenzi; Sarah J Tabrizi; Ruth Luthi-Carter
Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(36):14424-9.
2007: Alexandre Kuhn; Darlene R Goldstein; Angela Hodges; Andrew D Strand; Thierry Sengstag; Charles Kooperberg; Kristina Becanovic; Mahmoud A Pouladi; Kirupa Sathasivam; Jang-Ho Cha; Anthony J Hannan; Michael R Hayden; Blair R Leavitt; Stephen B Dunnett; Robert J Ferrante; Roger L Albin; Peggy F Shelbourne; Mauro Delorenzi; Sarah J Augood; Richard L M Faull; James M Olson; Gillian P Bates; Lesley Jones; Ruth Luthi-Carter
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
Human molecular genetics 2007;16(15):1845-61.
2007: Edward C Stack; Steven J Del Signore; Ruth Luthi-Carter; Byoung Y Soh; Darlene R Goldstein; Samantha Matson; Sarah Goodrich; Angela L Markey; Kerry Cormier; Sean W Hagerty; Karen Smith; Hoon Ryu; Robert J Ferrante
Modulation of nucleosome dynamics in Huntington's disease.
Human molecular genetics 2007;16(10):1164-75.
2007: Valérie Perrin; Etienne Régulier; Toufik Abbas-Terki; Raymonde Hassig; Emmanuel Brouillet; Patrick Aebischer; Ruth Luthi-Carter; Nicole Deglon
Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(5):903-11.
2006: Angela Hodges; Andrew D Strand; Aaron Aragaki; Alexandre Kuhn; Thierry Sengstag; Gareth Hughes; Lyn A Elliston; Cathy Hartog; Darlene R Goldstein; Doris Thu; Zane R Hollingsworth; Francois Collin; Beth Synek; Peter Holmans; Anne B Young; Nancy S Wexler; Mauro Delorenzi; Charles Kooperberg; Sarah J Augood; Richard L M Faull; James M Olson; Lesley Jones; Ruth Luthi-Carter
Regional and cellular gene expression changes in human Huntington's disease brain.
Human molecular genetics 2006;15(6):965-77.
2006: Lesley Jones; Darlene R Goldstein; Gareth Hughes; Andrew D Strand; Francois Collin; Stephen B Dunnett; Charles Kooperberg; Aaron Aragaki; James M Olson; Sarah J Augood; Richard L M Faull; Ruth Luthi-Carter; Valentina Moskvina; Angela K Hodges
Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data.
BMC bioinformatics 2006;7():211.
2005: Birgit Zucker; Ruth Luthi-Carter; Jibrin A Kama; Anthone W Dunah; Edward A Stern; Jonathan H Fox; David G Standaert; Anne B Young; Sarah J Augood
Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1.
Human molecular genetics 2005;14(2):179-89.
2004: Paolo Guidetti; Ruth Luthi-Carter; Sarah J Augood; Robert Schwarcz
Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease.
Neurobiology of disease 2004;17(3):455-61.
2003: Ruth Luthi-Carter; Barbara L Apostol; Anthone W Dunah; Molly M DeJohn; Laurie A Farrell; Gillian P Bates; Anne B Young; David G Standaert; Leslie Michels Thompson; Jang-Ho Cha
Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation.
Neurobiology of disease 2003;14(3):624-36.
2003: Robert J Ferrante; James K Kubilus; Junghee Lee; Hoon Ryu; Ayshe Beesen; Birgit Zucker; Karen Smith; Neil W Kowall; Rajiv R Ratan; Ruth Luthi-Carter; Steven M Hersch
Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(28):9418-27.
2003: Ruth Luthi-Carter
Progress towards a vaccine for Huntington's disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(5 Pt 1):569-70.
2002: Edmond Y W Chan; Ruth Luthi-Carter; Andrew D Strand; Steven M Solano; Sarah A Hanson; Molly M DeJohn; Charles Kooperberg; Kathryn O Chase; Marian DiFiglia; Anne B Young; Blair R Leavitt; Jang-Ho Cha; Neil Aronin; Michael R Hayden; James M Olson
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
Human molecular genetics 2002;11(17):1939-51.
2002: Ruth Luthi-Carter; Andrew D Strand; Sarah A Hanson; Charles Kooperberg; Gabriele Schilling; Albert R La Spada; Diane E Merry; Anne B Young; Christopher A Ross; David R Borchelt; James M Olson
Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects.
Human molecular genetics 2002;11(17):1927-37.
2002: Ruth Luthi-Carter; Sarah A Hanson; Andrew D Strand; Donald Bergstrom; Wanjoo Chun; Nikki L Peters; Annette M Woods; Edmond Y W Chan; Charles Kooperberg; Dimitri Krainc; Anne B Young; Stephen J Tapscott; James M Olson
Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain.
Human molecular genetics 2002;11(17):1911-26.
2002: Boris S Spektor; David W Miller; Zane R Hollingsworth; Yoshio A Kaneko; Steven M Solano; Jennifer M Johnson; John B Penney; Anne B Young; Ruth Luthi-Carter
Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease.
Brain research. Molecular brain research 2002;102(1-2):118-28.
2000: Ruth Luthi-Carter; Andrew D Strand; N L Peters; Steven M Solano; Zane R Hollingsworth; A S Menon; AS Frey; B S Spektor; E B Penney; Gabriele Schilling; Christopher A Ross; David R Borchelt; Stephen J Tapscott; Anne B Young; Jang-Ho Cha; James M Olson
Decreased expression of striatal signaling genes in a mouse model of Huntington's disease.
Human molecular genetics 2000;9(9):1259-71.
1999: Urs V Berger; Ruth Luthi-Carter; LA Passani; S Elkabes; I Black; Christine Konradi; Joseph T Coyle
Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system.
The Journal of comparative neurology 1999;415(1):52-64.
1999: HS Speno; Ruth Luthi-Carter; W L Macias; S L Valentine; A R Joshi; Joseph T Coyle
Site-directed mutagenesis of predicted active site residues in glutamate carboxypeptidase II.
Molecular pharmacology 1999;55(1):179-85.
1998: Charles H Halsted; EH Ling; Ruth Luthi-Carter; Jesus A Villanueva; J M Gardner; Joseph T Coyle
Folylpoly-gamma-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II.
The Journal of biological chemistry 1998;273(32):20417-24.
1998: Ruth Luthi-Carter; Amy K Barczak; HS Speno; Joseph T Coyle
Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase).
The Journal of pharmacology and experimental therapeutics 1998;286(2):1020-5.
1998: Ruth Luthi-Carter; Amy K Barczak; HS Speno; Joseph T Coyle
Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II.
Brain research 1998;795(1-2):341-8.
1998: Ruth Luthi-Carter; Urs V Berger; Amy K Barczak; M Enna; Joseph T Coyle
Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):3215-20.
1997: Lianna R Orlando; Ruth Luthi-Carter; David G Standaert; Joseph T Coyle; John B Penney; Anne B Young
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo.
Neuroscience letters 1997;236(2):91-4.