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Samuel Lux

Research Profile

Chemicals & Drugs

Anatomy

Disorders

Hereditary Spherocytosis

Living Beings

Concepts & Ideas

Molecular Sequence Data

Genes & Molecular Sequences

Amino Acid Sequences

Procedures

Phenomena

Protein Binding

Co-author Network

Publications

TOP 3
David A Williams; Elise S Porter; Samuel E Lux; Holcombe E Grier; Jennifer W Mack; Stuart H Orkin
Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute.
Michael C Stankewich; Babette Gwynn; Thomas Ardito; Lan Ji; Jung Kim; Raymond F Robledo; Samuel E Lux; Luanne L Peters; Jon S Morrow
Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes.
Raymond F Robledo; Lambert Amy; Connie S Birkenmeier; Marius V Cirlan; Andreea Flavia M Cirlan; Dean R Campagna; Samuel E Lux; Luanne L Peters
Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells.

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All Publications

2010: David A Williams; Elise S Porter; Samuel E Lux; Holcombe E Grier; Jennifer W Mack; Stuart H Orkin
Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute.
American journal of hematology 2010;85(10):793-4.
2010: Michael C Stankewich; Babette Gwynn; Thomas Ardito; Lan Ji; Jung Kim; Raymond F Robledo; Samuel E Lux; Luanne L Peters; Jon S Morrow
Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(13):6022-7.
2010: Raymond F Robledo; Lambert Amy; Connie S Birkenmeier; Marius V Cirlan; Andreea Flavia M Cirlan; Dean R Campagna; Samuel E Lux; Luanne L Peters
Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells.
Blood 2010;115(9):1804-14.
2010: C Korsgren; Luanne L Peters; Samuel E Lux
Protein 4.2 binds to the carboxyl-terminal EF-hands of erythroid alpha-spectrin in a calcium- and calmodulin-dependent manner.
The Journal of biological chemistry 2010;285(7):4757-70.
2004: Luanne L Peters; Rebecca A Swearingen; Sabra G Andersen; Babette Gwynn; Lambert Amy; Renhua Li; Samuel E Lux; Gary Churchill
Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency.
Blood 2004;103(8):3233-40.
2004: Stefan W Eber; Samuel E Lux
Hereditary spherocytosis--defects in proteins that connect the membrane skeleton to the lipid bilayer.
Seminars in hematology 2004;41(2):118-41.
2003: Refik Ozcan; Petr Jarolim; Samuel E Lux; Ernst J Ungewickell; Stefan W Eber
Simultaneous (AC)n microsatellite polymorphism analysis and single-stranded conformation polymorphism screening is an efficient strategy for detecting ankyrin-1 mutations in dominant hereditary spherocytosis.
British journal of haematology 2003;122(4):669-77.
2003: Barry H Paw; Alan J Davidson; Yi Zhou; Rong Li; Stephen J Pratt; Charles Lee; Nikolaus S Trede; Alison Brownlie; Adriana Donovan; Eric C Liao; James M Ziai; Anna H Drejer; Wen Guo; Carol H Kim; Babette Gwynn; Luanne L Peters; Marina N Chernova; Seth L Alper; Agustín Zapata; Sunitha N Wickramasinghe; Matthew J Lee; Samuel E Lux; Andreas Fritz; John H Postlethwait; Leonard I Zon
Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency.
Nature genetics 2003;34(1):59-64.
2001: WT Tse; J Tang; Ou Jin; C Korsgren; KM John; Andrew L Kung; Babette Gwynn; Luanne L Peters; Samuel E Lux
A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.
The Journal of biological chemistry 2001;276(26):23974-85.
2000: Patrick G Gallagher; M Romana; WT Tse; Samuel E Lux; Bernard G Forget
The human ankyrin-1 gene is selectively transcribed in erythroid cell lines despite the presence of a housekeeping-like promoter.
Blood 2000;96(3):1136-43.
2000: Adriana Donovan; Alison Brownlie; Yi Zhou; Jennifer Shepard; Stephen J Pratt; J Moynihan; Barry H Paw; Anna H Drejer; Bruce Barut; A Zapata; T C Law; C Brugnara; Samuel E Lux; Geraldine S Pinkus; Jack L Pinkus; Paul D Kingsley; James Palis; M D Fleming; Nancy C Andrews; Leonard I Zon
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.
Nature 2000;403(6771):776-81.
1999: Lars Jørn Jensen; Alan K Stuart-Tilley; Luanne L Peters; Samuel E Lux; Seth L Alper; Sylvie Breton
Immunolocalization of AE2 anion exchanger in rat and mouse epididymis.
Biology of reproduction 1999;61(4):973-80.
1999: Oksana Berezovska; M Frosch; Pamela J McLean; R Knowles; Edward H Koo; David E Kang; Jie Shen; F M Lu; Samuel E Lux; Susumu Tonegawa; Bradley T Hyman
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.
Brain research. Molecular brain research 1999;69(2):273-80.
1999: Luanne L Peters; H K Jindel; Babette Gwynn; C Korsgren; KM John; Samuel E Lux; N Mohandas; C M Cohen; Michael R Cho; David E Golan; C Brugnara
Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice.
The Journal of clinical investigation 1999;103(11):1527-37.
1999: Oksana Berezovska; Pamela J McLean; R Knowles; M Frosh; F M Lu; Samuel E Lux; Bradley T Hyman
Notch1 inhibits neurite outgrowth in postmitotic primary neurons.
Neuroscience 1999;93(2):433-9.
1999: WT Tse; Samuel E Lux
Red blood cell membrane disorders.
British journal of haematology 1999;104(1):2-13.
1998: Michael R Cho; Stefan W Eber; Shih-Chun Liu; Samuel E Lux; David E Golan
Regulation of band 3 rotational mobility by ankyrin in intact human red cells.
Biochemistry 1998;37(51):17828-35.
1998: Michael C Stankewich; WT Tse; Luanne L Peters; Y Ch'ng; KM John; Paul R Stabach; Prasad Devarajan; Jon S Morrow; Samuel E Lux
A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14158-63.
1998: RB Doctor; J Chen; Luanne L Peters; Samuel E Lux; LJ Mandel
Distribution of epithelial ankyrin (Ank3) spliceoforms in renal proximal and distal tubules.
The American journal of physiology 1998;274(1 Pt 2):F129-38.
1997: Patrick G Gallagher; WT Tse; A L Scarpa; Samuel E Lux; Bernard G Forget
Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing.
The Journal of biological chemistry 1997;272(31):19220-8.
1997: T C Hoock; Luanne L Peters; Samuel E Lux
Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes.
The Journal of cell biology 1997;136(5):1059-70.
1996: Luanne L Peters; Ramesh A Shivdasani; S C Liu; M Hanspal; K M John; J M Gonzalez; Carlo Brugnara; Babette Gwynn; N Mohandas; S L Alper; Stuart H Orkin; Samuel E Lux
Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton.
Cell 1996;86(6):917-27.
1996: O Shalev; E Shinar; Samuel E Lux
Isolated beta-globin chains reproduce, in normal red cell membranes, the defective binding of spectrin to alpha-thalassaemic membranes.
British journal of haematology 1996;94(2):273-8.
1996: Stefan W Eber; J M Gonzalez; M L Lux; A L Scarpa; WT Tse; M Dornwell; J Herbers; Wilfried Kugler; R Ozcan; Arnulf Pekrun; Patrick G Gallagher; W Schröter; Bernard G Forget; Samuel E Lux
Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis.
Nature genetics 1996;13(2):214-8.
1996: F M Lu; Samuel E Lux
Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5663-7.
1996: P B Jenkins; Ghassan K Abou-Alfa; Didier Dhermy; E Bursaux; C Féo; A L Scarpa; Samuel E Lux; Michel Garbarz; Bernard G Forget; Patrick G Gallagher
A nonsense mutation in the erythrocyte band 3 gene associated with decreased mRNA accumulation in a kindred with dominant hereditary spherocytosis.
The Journal of clinical investigation 1996;97(2):373-80.
1995: P A Piepenhagen; Luanne L Peters; Samuel E Lux; W James Nelson
Differential expression of Na(+)-K(+)-ATPase, ankyrin, fodrin, and E-cadherin along the kidney nephron.
The American journal of physiology 1995;269(6 Pt 1):C1417-32.
1995: Clinton H Joiner; Robert S Franco; M Jiang; M S Franco; J E Barker; Samuel E Lux
Increased cation permeability in mutant mouse red blood cells with defective membrane skeletons.
Blood 1995;86(11):4307-14.
1995: M B Morris; Samuel E Lux
Characterization of the binary interaction between human erythrocyte protein 4.1 and actin.
European journal of biochemistry / FEBS 1995;231(3):644-50.
1995: Luanne L Peters; K M John; F M Lu; E M Eicher; A Higgins; M Yialamas; L C Turtzo; A J Otsuka; Samuel E Lux
Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain.
The Journal of cell biology 1995;130(2):313-30.
1994: R A White; E N Geissler; L R Adkison; L L Dowler; S L Alper; Samuel E Lux
Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(12):827-9.
1993: O S Platt; Samuel E Lux; J F Falcone
A highly conserved region of human erythrocyte ankyrin contains the capacity to bind spectrin.
The Journal of biological chemistry 1993;268(32):24421-6.
1993: P Savvides; O Shalev; K M John; Samuel E Lux
Combined spectrin and ankyrin deficiency is common in autosomal dominant hereditary spherocytosis.
Blood 1993;82(10):2953-60.
1993: P S Becker; WT Tse; Samuel E Lux; Bernard G Forget
Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1.
The Journal of clinical investigation 1993;92(2):612-6.
1993: Connie S Birkenmeier; R A White; Luanne L Peters; E J Hall; Samuel E Lux; Jane E Barker
Complex patterns of sequence variation and multiple 5' and 3' ends are found among transcripts of the erythroid ankyrin gene.
The Journal of biological chemistry 1993;268(13):9533-40.
1993: Luanne L Peters; Nancy C Andrews; E M Eicher; M B Davidson; Stuart H Orkin; Samuel E Lux
Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2.
Nature 1993;362(6422):768-70.
1993: Luanne L Peters; Samuel E Lux
Ankyrins: structure and function in normal cells and hereditary spherocytes.
Seminars in hematology 1993;30(2):85-118.
1992: R A White; Luanne L Peters; L R Adkison; C Korsgren; C M Cohen; Samuel E Lux
The murine pallid mutation is a platelet storage pool disease associated with the protein 4.2 (pallidin) gene.
Nature genetics 1992;2(1):80-3.
1992: Luanne L Peters; R A White; Connie S Birkenmeier; MIchael Bloom; Samuel E Lux; Jane E Barker
Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):5749-53.
1992: R A White; Connie S Birkenmeier; Luanne L Peters; Jane E Barker; Samuel E Lux
Murine erythrocyte ankyrin cDNA: highly conserved regions of the regulatory domain.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;3(5):281-5.
1992: Patrick G Gallagher; WT Tse; A L Scarpa; Samuel E Lux; Bernard G Forget
Large numbers of alternatively spliced isoforms of the regulatory region of human erythrocyte ankyrin.
Transactions of the Association of American Physicians 1992;105():268-77.
1991: Luanne L Peters; Connie S Birkenmeier; Roderick T Bronson; R A White; Samuel E Lux; E Otto; V Bennett; A Higgins; Jane E Barker
Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice.
The Journal of cell biology 1991;114(6):1233-41.
1991: WT Tse; J C Menninger; TL Yang-Feng; U Francke; K E Sahr; Samuel E Lux; David C Ward; Bernard G Forget
Isolation and chromosomal localization of a novel nonerythroid ankyrin gene.
Genomics 1991;10(4):858-66.
1990: P S Becker; M A Schwartz; Jon S Morrow; Samuel E Lux
Radiolabel-transfer cross-linking demonstrates that protein 4.1 binds to the N-terminal region of beta spectrin and to actin in binary interactions.
European journal of biochemistry / FEBS 1990;193(3):827-36.
1990: F F Costa; Peter Agre; P C Watkins; J C Winkelmann; T K Tang; K M John; Samuel E Lux; Bernard G Forget
Linkage of dominant hereditary spherocytosis to the gene for the erythrocyte membrane-skeleton protein ankyrin.
The New England journal of medicine 1990;323(15):1046-50.
1990: Samuel E Lux; WT Tse; J C Menninger; K M John; P Harris; O Shalev; R R Chilcote; S L Marchesi; P C Watkins; V Bennett
Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8.
Nature 1990;345(6277):736-9.
1990: R A White; Connie S Birkenmeier; Samuel E Lux; Jane E Barker
Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3117-21.
1990: Samuel E Lux; K M John; V Bennett
Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins.
Nature 1990;344(6261):36-42.
1990: WT Tse; J C Menninger; David C Ward; R R Chilcote; K M John; Samuel E Lux; Bernard G Forget
Demonstration of the deletion of a copy of the ankyrin gene in a patient with hereditary spherocytosis by in situ hybridization.
Transactions of the Association of American Physicians 1990;103():242-8.
1989: Samuel E Lux; K M John; R R Kopito; Harvey Lodish
Cloning and characterization of band 3, the human erythrocyte anion-exchange protein (AE1).
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9089-93.
1989: L Davis; Samuel E Lux; Vann Bennett
Mapping the ankyrin-binding site of the human erythrocyte anion exchanger.
The Journal of biological chemistry 1989;264(16):9665-72.
1989: E Shinar; E A Rachmilewitz; Samuel E Lux
Differing erythrocyte membrane skeletal protein defects in alpha and beta thalassemia.
The Journal of clinical investigation 1989;83(2):404-10.
1987: P S Becker; Jon S Morrow; Samuel E Lux
Abnormal oxidant sensitivity and beta-chain structure of spectrin in hereditary spherocytosis associated with defective spectrin-protein 4.1 binding.
The Journal of clinical investigation 1987;80(2):557-65.
1986: L C Wolfe; A M Byrne; Samuel E Lux
Molecular defect in the membrane skeleton of blood bank-stored red cells. Abnormal spectrin-protein 4.1-actin complex formation.
The Journal of clinical investigation 1986;78(6):1681-6.
1986: Clinton H Joiner; O S Platt; Samuel E Lux
Cation depletion by the sodium pump in red cells with pathologic cation leaks. Sickle cells and xerocytes.
The Journal of clinical investigation 1986;78(6):1487-96.
1986: P S Becker; C M Cohen; Samuel E Lux
The effect of mild diamide oxidation on the structure and function of human erythrocyte spectrin.
The Journal of biological chemistry 1986;261(10):4620-8.
1985: G H Beaven; L Jean-Baptiste; E Ungewickell; A J Baines; F Shahbakhti; Jennifer C Pinder; Samuel E Lux; Walter Gratzer
An examination of the soluble oligomeric complexes extracted from the red cell membrane and their relation to the membrane cytoskeleton.
European journal of cell biology 1985;36(2):299-306.
1985: P S Becker; Samuel E Lux
Hereditary spherocytosis and related disorders.
Clinics in haematology 1985;14(1):15-43.
1985: P S Becker; Samuel E Lux
The effect of oxidation on the structure and function of human erythrocyte spectrin.
Progress in clinical and biological research 1985;195():185-93.
1985: O S Platt; J F Falcone; Samuel E Lux
Molecular defect in the sickle erythrocyte skeleton. Abnormal spectrin binding to sickle inside-our vesicles.
The Journal of clinical investigation 1985;75(1):266-71.
1984: D S Beardsley; J E Spiegel; M M Jacobs; R I Handin; Samuel E Lux
Platelet membrane glycoprotein IIIa contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias.
The Journal of clinical investigation 1984;74(5):1701-7.
1984: V Ohanian; L C Wolfe; K M John; Jennifer C Pinder; Samuel E Lux; Walter Gratzer
Analysis of the ternary interaction of the red cell membrane skeletal proteins spectrin, actin, and 4.1.
Biochemistry 1984;23(19):4416-20.
1984: J E Spiegel; D S Beardsley; F S Southwick; Samuel E Lux
An analogue of the erythroid membrane skeletal protein 4.1 in nonerythroid cells.
The Journal of cell biology 1984;99(3):886-93.
1983: Jennifer C Pinder; D Dhermy; A J Baines; Samuel E Lux; Walter Gratzer
A phenomenological difference between membrane skeletal protein complexes isolated from normal and hereditary spherocytosis erythrocytes.
British journal of haematology 1983;55(3):455-63.
1983: P S Becker; J E Spiegel; L C Wolfe; Samuel E Lux
High yield purification of protein 4.1 from human erythrocyte membranes.
Analytical biochemistry 1983;132(1):195-201.
1983: A E Unger; M J Harris; S E Bernstein; J C Falcone; Samuel E Lux
Hemolytic anemia in the mouse. Report of a new mutation and clarification of its genetics.
The Journal of heredity 1983;74(2):88-92.
1982: L C Wolfe; K M John; J C Falcone; A M Byrne; Samuel E Lux
A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis.
The New England journal of medicine 1982;307(22):1367-74.
1982: N Mohandas; M R Clark; B P Health; M Rossi; L C Wolfe; Samuel E Lux; S B Shohet
A technique to detect reduced mechanical stability of red cell membranes: relevance to elliptocytic disorders.
Blood 1982;59(4):768-74.
1981: O S Platt; Samuel E Lux; D G Nathan
Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity.
The Journal of clinical investigation 1981;68(3):631-8.
1981: M B Tomaselli; K M John; Samuel E Lux
Elliptical erythrocyte membrane skeletons and heat-sensitive spectrin in hereditary elliptocytosis.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(3):1911-5.
1981: Samuel E Lux; L C Wolfe; B Pease; M B Tomaselli; K M John; S E Bernstein
Hemolytic anemias due to abnormalities in red cell spectrin: a brief review.
Progress in clinical and biological research 1981;45():159-68.
1980: Samuel E Lux; L C Wolfe
Inherited disorders of the red cell membrane skeleton.
Pediatric clinics of North America 1980;27(2):463-86.