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James Luyendyk

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Bradley P Sullivan; Nigel Mackman; Cheryl Rockwell; Stephanie C Bishop; Juliette A Brown; Holly Cline; Nikita Joshi; Karen M Kassel; Anna K Kopec; James P Luyendyk
Hepatocyte tissue factor activates the coagulation cascade in mice.
Silvio Antoniak; Martin Baunacke; Melinda A Beck; Burns C Blaxall; Denise A Esserman; Daniel Kirchhofer; Rebecca D Lee; James P Luyendyk; Ronny Malz; A Phillip Owens; Rafal Pawlinski; Ursula Rauch; Patricia A Sheridan; JoAnn Trejo; Alice Weithäuser; Julie C Williams; Nigel Mackman
PAR-1 contributes to the innate immune response during viral infection.
Karen M Kassel; Bryan L Copple; Wei Cui; Bradley P Sullivan; James P Luyendyk
Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease.

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All Publications

2013: Bradley P Sullivan; Nigel Mackman; Cheryl Rockwell; Stephanie C Bishop; Juliette A Brown; Holly Cline; Nikita Joshi; Karen M Kassel; Anna K Kopec; James P Luyendyk
Hepatocyte tissue factor activates the coagulation cascade in mice.
Blood 2013;121(10):1868-74.
2013: Silvio Antoniak; Martin Baunacke; Melinda A Beck; Burns C Blaxall; Denise A Esserman; Daniel Kirchhofer; Rebecca D Lee; James P Luyendyk; Ronny Malz; A Phillip Owens; Rafal Pawlinski; Ursula Rauch; Patricia A Sheridan; JoAnn Trejo; Alice Weithäuser; Julie C Williams; Nigel Mackman
PAR-1 contributes to the innate immune response during viral infection.
The Journal of clinical investigation 2013;123(3):1310-22.
2012: Karen M Kassel; Bryan L Copple; Wei Cui; Bradley P Sullivan; James P Luyendyk
Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease.
The American journal of pathology 2012;181(4):1287-95.
2012: Bradley P Sullivan; Matthew J Flick; Alice Jone; Karen M Kassel; James P Luyendyk
Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury.
The American journal of pathology 2012;180(6):2321-9.
2012: Karen M Kassel; Bradley P Sullivan; James P Luyendyk
Lipopolysaccharide enhances transforming growth factor β1-induced platelet-derived growth factor-B expression in bile duct epithelial cells.
Journal of gastroenterology and hepatology 2012;27(4):714-21.
2012: Bradley P Sullivan; Bryan L Copple; Wei Cui; James P Luyendyk
Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(1):267-74.
2012: A Phillip Owens; Freda H Passam; Lawrence Rudel; Ryan E Temel; Peter S Tobias; Jianguo Wang; Julie C Williams; Stephanie M Marshall; Allison L McDaniel; Patrick M Moriarty; Shanmugam Nagarajan; Silvio Antoniak; Linda K Curtiss; Alan Daugherty; Julie-Ann Dutton; Bruce Furie; Barbara C Furie; Brian K Hubbard; Douglas G Johns; Daniel Kirchhofer; James P Luyendyk; Nigel Mackman
Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin.
The Journal of clinical investigation 2012;122(2):558-68.
2011: Karen M Kassel; Guodong Li; Grace L Guo; Nigel Mackman; A Phillip Owens; Cheryl E Rockwell; Bradley P Sullivan; Ossama Tawfik; Ruipeng Wang; James P Luyendyk
Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet.
The American journal of pathology 2011;179(5):2278-89.
2011: Shuang Mei; Hong-Min Ni; Abigail Bockus; Bryan L Copple; Karen M Kassel; James P Luyendyk; Sharon Manley; Wen-Xing Ding
Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes.
The Journal of pharmacology and experimental therapeutics 2011;339(2):487-98.
2011: James P Luyendyk; Grace L Guo
Steatosis DeLIVERs high-sensitivity C-reactive protein.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(8):1714-5.
2011: Erica M Sparkenbaugh; Yogesh Saini; Bryan L Copple; Patricia E Ganey; Krista K Greenwood; John J LaPres; James P Luyendyk; Jane F Maddox; Robert A Roth
The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 2011;338(2):492-502.
2011: Bradley P Sullivan; Karen M Kassel; Sharon Manley; Alyson K Baker; James P Luyendyk
Regulation of transforming growth factor-β1-dependent integrin β6 expression by p38 mitogen-activated protein kinase in bile duct epithelial cells.
The Journal of pharmacology and experimental therapeutics 2011;337(2):471-8.
2011: James P Luyendyk; Karen M Kassel; Katryn Allen; Grace L Guo; Guodong Li; Glenn H Cantor; Bryan L Copple
Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis.
The American journal of pathology 2011;178(3):1117-25.
2011: James P Luyendyk; Kevin C Flanagan; C David Williams; Hartmut Jaeschke; Joyce G Slusser; Nigel Mackman; Glenn H Cantor
Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.
Toxicology and applied pharmacology 2011;250(3):256-62.
2011: James P Luyendyk; Nigel Mackman; Bradley P Sullivan
Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(1):233-43.
2010: Bradley P Sullivan; Paul H Weinreb; Shelia M Violette; James P Luyendyk
The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.
The American journal of pathology 2010;177(6):2837-49.
2010: Karen M Kassel; Grace L Guo; Ossama Tawfik; James P Luyendyk
Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet.
Laboratory investigation; a journal of technical methods and pathology 2010;90(12):1794-804.
2010: Patrick M Moriarty; James P Luyendyk; Cheryl Gibson; James M Backes
Effect of low-density lipoprotein apheresis on plasma levels of apolipoprotein e4.
The American journal of cardiology 2010;105(11):1585-7.
2010: Bradley P Sullivan; Ruipeng Wang; Ossama Tawfik; James P Luyendyk
Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies.
Toxicological sciences : an official journal of the Society of Toxicology 2010;115(1):286-94.
2010: Michael J Liguori; Amy C Ditewig; Jane F Maddox; James P Luyendyk; Lois D Lehman-McKeeman; David M Nelson; Vasanthi M Bhaskaran; Jeffrey F Waring; Patricia E Ganey; Robert A Roth; Eric A G Blomme
Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example.
International journal of molecular sciences 2010;11(11):4697-714.
2010: James P Luyendyk; Bradley P Sullivan; Grace L Guo; Ruipeng Wang
Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice.
The American journal of pathology 2010;176(1):177-86.
2009: Xiaomin Deng; James P Luyendyk; Patricia E Ganey; Robert A Roth
Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models.
Pharmacological reviews 2009;61(3):262-82.
2009: Alyson K Baker; Ruipeng Wang; Nigel Mackman; James P Luyendyk
Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression.
Molecular immunology 2009;46(11-12):2249-55.
2009: Juliane I Beier; James P Luyendyk; Luping Guo; Claudia von Montfort; Donald E Staunton; Gavin E Arteel
Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice.
Hepatology (Baltimore, Md.) 2009;49(5):1545-53.
2009: James P Luyendyk; Glenn H Cantor; Daniel Kirchhofer; Nigel Mackman; Bryan L Copple; Ruipeng Wang
Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(4):G840-9.
2008: Joanne Yu; Linda May; Chloe Milsom; G Mark Anderson; Jeffrey I Weitz; James P Luyendyk; George Broze; Nigel Mackman; Janusz Rak
Contribution of host-derived tissue factor to tumor neovascularization.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(11):1975-81.
2008: Linda B Kidd; Gernot A Schabbauer; James P Luyendyk; Todd Holscher; Rachel E Tilley; Michael Tencati; Nigel Mackman
Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice.
The Journal of pharmacology and experimental therapeutics 2008;326(1):348-53.
2008: James P Luyendyk; Gernot A Schabbauer; Michael Tencati; Todd Holscher; Rafal Pawlinski; Nigel Mackman
Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):4218-26.
2007: Francis F Tukov; James P Luyendyk; Patricia E Ganey; Robert A Roth
The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):267-80.
2007: Patricia E Ganey; James P Luyendyk; Sandra W Newport; Theresa M Eagle; Jane F Maddox; Nigel Mackman; Robert A Roth
Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice.
Hepatology (Baltimore, Md.) 2007;46(4):1177-86.
2007: Mallika Ghosh; Haibin Wang; Youxi Ai; Elisa Romeo; James P Luyendyk; Jeffrey M Peters; Nigel Mackman; Sudhansu K Dey; timothy hla
COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation.
The Journal of experimental medicine 2007;204(9):2053-61.
2007: James P Luyendyk; J Daniel Piper; Michael Tencati; K Veera Reddy; Todd Holscher; Rong Zhang; Jayraz Luchoomun; Xilin Chen; Wang Min; Charles Kunsch; Nigel Mackman
A novel class of antioxidants inhibit LPS induction of tissue factor by selective inhibition of the activation of ASK1 and MAP kinases.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(8):1857-63.
2007: Xiaomin Deng; James P Luyendyk; Wei Zou; Jingtao Lu; Ernst Malle; Patricia E Ganey; Robert A Roth
Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine.
The Journal of pharmacology and experimental therapeutics 2007;322(2):852-61.
2007: Chloe Milsom; Joanne Yu; Linda May; Brian Meehan; Nathalie Magnus; Khalid Al-Nedawi; James P Luyendyk; Jefferey Weitz; Petr Klement; George Broze; Nigel Mackman; Janusz Rak
The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression.
Thrombosis research 2007;120 Suppl 2():S82-91.
2006: Xiaomin Deng; Robert F Stachlewitz; Michael J Liguori; Eric A G Blomme; Jeffrey F Waring; James P Luyendyk; Jane F Maddox; Patricia E Ganey; Robert A Roth
Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation.
The Journal of pharmacology and experimental therapeutics 2006;319(3):1191-9.
2006: Ina Bergheim; Luping Guo; Molly Anne Davis; Jason C Lambert; Juliane I Beier; Ilinca Duveau; James P Luyendyk; Robert A Roth; Gavin E Arteel
Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1.
Gastroenterology 2006;130(7):2099-112.
2006: James P Luyendyk; Rachel E Tilley; Nigel Mackman
Genetic susceptibility to thrombosis.
Current atherosclerosis reports 2006;8(3):193-7.
2006: James P Luyendyk; Lois D Lehman-McKeeman; David M Nelson; Vasanthi M Bhaskaran; Timothy P Reilly; Bruce D Car; Glenn H Cantor; Xiaomin Deng; Jane F Maddox; Patricia E Ganey; Robert A Roth
Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine.
The Journal of pharmacology and experimental therapeutics 2006;317(2):635-43.
2006: James P Luyendyk; Lois D Lehman-McKeeman; David M Nelson; Vasanthi M Bhaskaran; Timothy P Reilly; Bruce D Car; Glenn H Cantor; Jane F Maddox; Patricia E Ganey; Robert A Roth
Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine.
Toxicological sciences : an official journal of the Society of Toxicology 2006;90(2):569-85.
2006: Jane F Maddox; James P Luyendyk; Gregory N Cosma; Alan P Breau; Roy H Bible; George G Harrigan; Royston Goodacre; Patricia E Ganey; Glenn H Cantor; Gary L Cockerell; Robert A Roth
Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide.
Toxicology and applied pharmacology 2006;212(1):35-44.
2006: Ina Bergheim; James P Luyendyk; Chad Steele; Gilandra K Russell; Luping Guo; Robert A Roth; Gavin E Arteel
Metformin prevents endotoxin-induced liver injury after partial hepatectomy.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1053-61.
2006: Jeffrey F Waring; Michael J Liguori; James P Luyendyk; Jane F Maddox; Patricia E Ganey; Robert F Stachlewitz; Colin North; Eric A G Blomme; Robert A Roth
Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1080-7.
2005: James P Luyendyk; Patrick J Shaw; Christopher D Green; Jane F Maddox; Patricia E Ganey; Robert A Roth
Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1023-31.
2004: James P Luyendyk; Jane F Maddox; Christopher D Green; Patricia E Ganey; Robert A Roth
Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats.
Hepatology (Baltimore, Md.) 2004;40(6):1342-51.
2004: Patricia E Ganey; James P Luyendyk; Jane F Maddox; Robert A Roth
Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor.
Chemico-biological interactions 2004;150(1):35-51.
2004: James P Luyendyk; William Mattes; Lyle Burgoon; Timothy R Zacharewski; Jane F Maddox; Gregory N Cosma; Patricia E Ganey; Robert A Roth
Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine.
Toxicological sciences : an official journal of the Society of Toxicology 2004;80(1):203-13.
2004: George G Harrigan; Roxanne H LaPlante; Gregory N Cosma; Gary L Cockerell; Royston Goodacre; Jane F Maddox; James P Luyendyk; Patricia E Ganey; Robert A Roth
Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity.
Toxicology letters 2004;146(3):197-205.
2003: Robert A Roth; James P Luyendyk; Jane F Maddox; Patricia E Ganey
Inflammation and drug idiosyncrasy--is there a connection?
The Journal of pharmacology and experimental therapeutics 2003;307(1):1-8.
2003: James P Luyendyk; Jane F Maddox; Gregory N Cosma; Patricia E Ganey; Gary L Cockerell; Robert A Roth
Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats.
The Journal of pharmacology and experimental therapeutics 2003;307(1):9-16.
2003: James P Luyendyk; Bryan L Copple; Charles C Barton; Patricia E Ganey; Robert A Roth
Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: involvement of endothelium and the coagulation system.
Toxicological sciences : an official journal of the Society of Toxicology 2003;72(1):171-81.
2002: James P Luyendyk; Kate C Shores; Patricia E Ganey; Robert A Roth
Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(1):220-5.