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Walter Luyten

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Gerben Menschaert; Tom T M Vandekerckhove; Geert Baggerman; Liliane Schoofs; Walter H M L Luyten; Wim van Criekinge
Peptidomics coming of age: a review of contributions from a bioinformatics angle.
Gerben Menschaert; Tom T M Vandekerckhove; Geert Baggerman; Bart Landuyt; Jonathan V Sweedler; Liliane Schoofs; Walter H M L Luyten; Wim van Criekinge
A hybrid, de novo based, genome-wide database search approach applied to the sea urchin neuropeptidome.
Kurt Boonen; Steven J Husson; Bart Landuyt; Geert Baggerman; Eisuke Hayakawa; Walter H M L Luyten; Liliane Schoofs
Identification and relative quantification of neuropeptides from the endocrine tissues.

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All Publications

2010: Gerben Menschaert; Tom T M Vandekerckhove; Geert Baggerman; Liliane Schoofs; Walter H M L Luyten; Wim van Criekinge
Peptidomics coming of age: a review of contributions from a bioinformatics angle.
Journal of proteome research 2010;9(5):2051-61.
2010: Gerben Menschaert; Tom T M Vandekerckhove; Geert Baggerman; Bart Landuyt; Jonathan V Sweedler; Liliane Schoofs; Walter H M L Luyten; Wim van Criekinge
A hybrid, de novo based, genome-wide database search approach applied to the sea urchin neuropeptidome.
Journal of proteome research 2010;9(2):990-6.
2010: Kurt Boonen; Steven J Husson; Bart Landuyt; Geert Baggerman; Eisuke Hayakawa; Walter H M L Luyten; Liliane Schoofs
Identification and relative quantification of neuropeptides from the endocrine tissues.
Methods in molecular biology (Clifton, N.J.) 2010;615():191-206.
2009: Gerben Menschaert; Tom T M Vandekerckhove; Bart Landuyt; Eisuke Hayakawa; Liliane Schoofs; Walter H M L Luyten; Wim van Criekinge
Spectral clustering in peptidomics studies helps to unravel modification profile of biologically active peptides and enhances peptide identification rate.
Proteomics 2009;9(18):4381-8.
2009: G Menschaert; Tom T M Vandekerckhove; Geert Baggerman; Bart Landuyt; Liliane Schoofs; Walter H M L Luyten; Wim van Criekinge
Bioinformatics solutions for MS/MS interpretation tailored to the peptidomics field.
Communications in agricultural and applied biological sciences 2009;74(4):67-73.
2007: Leen Thielemans; Pieter J Peeters; Heidi Jonckheere; Walter H M L Luyten; Ronald de Hoogt; Bernard Coulie; Jeroen Aerssens
The hepatocarcinoma cell line HepG2 does not express a GHS-R1a-type ghrelin receptor.
Journal of receptor and signal transduction research 2007;27(4):309-22.
2005: Cécile-Marie Aliouat-Denis; Najoua Dendouga; Ilse Van den Wyngaert; Hinrich Göhlmann; Ulf Steller; Inez Van de Weyer; Nele Van Slycken; Luc Andries; Stefan U Kass; Walter H M L Luyten; Michel Janicot; Jorge Vialard
p53-independent regulation of p21Waf1/Cip1 expression and senescence by Chk2.
Molecular cancer research : MCR 2005;3(11):627-34.
2004: Pieter J Peeters; Alexis Baker; Ilse Goris; Guy Daneels; Peter Verhasselt; Walter H M L Luyten; Johan JGH Geysen; Stefan U Kass; Dieder Moechars
Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53.
Brain research. Developmental brain research 2004;150(2):89-101.
2003: Yasumichi Hitoshi; Tarikere L Gururaja; Denise M Pearsall; Wayne Lang; Poonam Sharma; Betty Huang; Susan M Catalano; John McLaughlin; Erlina Pali; Beau Peelle; Jorge Vialard; Michel Janicot; Walter Wouters; Walter H M L Luyten; Mark K Bennett; Dave C Anderson; Donald G Payan; James B Lorens; Jakob Bogenberger; Susan D Demo
Cellular localization and antiproliferative effect of peptides discovered from a functional screen of a retrovirally delivered random peptide library.
Chemistry & biology 2003;10(10):975-87.
2003: Dirk Van Oekelen; Anton Megens; Theo F Meert; Walter H M L Luyten; Josée E Leysen
Functional study of rat 5-HT2A receptors using antisense oligonucleotides.
Journal of neurochemistry 2003;85(5):1087-100.
2003: Dirk Van Oekelen; Walter H M L Luyten; Josée E Leysen
Ten years of antisense inhibition of brain G-protein-coupled receptor function.
Brain research. Brain research reviews 2003;42(2):123-42.
2003: Dirk Van Oekelen; Walter H M L Luyten; Josée E Leysen
5-HT2A and 5-HT2C receptors and their atypical regulation properties.
Life sciences 2003;72(22):2429-49.
2002: Dirk Van Oekelen; Anton Megens; Theo F Meert; Walter H M L Luyten; Josée E Leysen
Role of 5-HT(2) receptors in the tryptamine-induced 5-HT syndrome in rats.
Behavioural pharmacology 2002;13(4):313-8.
2002: Eckhard Bender; Arjan Buist; Mirek Jurzak; Xavier Langlois; Geert Baggerman; Peter Verhasselt; Martine Ercken; Hong-Qing Guo; Cindy Wintmolders; Ilse Van den Wyngaert; Irma Van Oers; Liliane Schoofs; Walter H M L Luyten
Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8573-8.
2002: Marianne D De Backer; Patrick Van Dijck; Walter H M L Luyten
Functional genomics approaches for the identification and validation of antifungal drug targets.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 2002;2(2):113-27.
2001: D V Oekelen; Mirek Jurzak; D Van de Wiel; Geert van Hecke; Walter H M L Luyten; Josée E Leysen
Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone.
European journal of pharmacology 2001;425(1):21-32.
2001: Marianne D De Backer; T Ilyina; X J Ma; S Vandoninck; Walter H M L Luyten; H Vanden Bossche
Genomic profiling of the response of Candida albicans to itraconazole treatment using a DNA microarray.
Antimicrobial agents and chemotherapy 2001;45(6):1660-70.
2001: Marianne D De Backer; B Nelissen; M Logghe; J Viaene; I Loonen; S Vandoninck; Ronald de Hoogt; Sylviane Dewaele; F A Simons; Peter Verhasselt; G Vanhoof; Roland Contreras; Walter H M L Luyten
An antisense-based functional genomics approach for identification of genes critical for growth of Candida albicans.
Nature biotechnology 2001;19(3):235-41.
2001: BJ Francken; JF Vanhauwe; Katty Josson; Mirek Jurzak; Walter H M L Luyten; Josée E Leysen
Reconstitution of human 5-hydroxytryptamine5A receptor--G protein coupling in E. coli and Sf9 cell membranes with membranes from Sf9 cells expressing mammalian G proteins.
Receptors & channels 2001;7(4):303-18.
2000: JF Vanhauwe; Katty Josson; Walter H M L Luyten; A J Driessen; Josée E Leysen
G-protein sensitivity of ligand binding to human dopamine D(2) and D(3) receptors expressed in Escherichia coli: clues for a constrained D(3) receptor structure.
The Journal of pharmacology and experimental therapeutics 2000;295(1):274-83.
2000: Ilse Van den Wyngaert; W de Vries; Andreas Kremer; Jean-Marc Neefs; Peter Verhasselt; Walter H M L Luyten; Stefan U Kass
Cloning and characterization of human histone deacetylase 8.
FEBS letters 2000;478(1-2):77-83.
2000: Aimée D C Paulussen; Karel Lavrijsen; Hilde Bohets; Jan Hendrickx; Peter Verhasselt; Walter H M L Luyten; F Konings; Martin Armstrong
Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans.
Pharmacogenetics 2000;10(5):415-24.
2000: Ronald de Hoogt; Walter H M L Luyten; Roland Contreras; Marianne D De Backer
PCR- and ligation-mediated synthesis of split-marker cassettes with long flanking homology regions for gene disruption in Candida albicans.
BioTechniques 2000;28(6):1112-6.
2000: M Paola Castelli; Ignazia Mocci; Xavier Langlois; W Gommerendagger; Walter H M L Luyten; J E Leysen; Gian Luigi Gessa
Quantitative autoradiographic distribution of gamma-hydroxybutyric acid binding sites in human and monkey brain.
Brain research. Molecular brain research 2000;78(1-2):91-9.
2000: Aimée D C Paulussen; P Yang; M Pangalos; Peter Verhasselt; R Marrannes; C Verfaille; I Vandenberk; R Crabbe; F Konings; Walter H M L Luyten; Martin Armstrong
Analysis of the human KCNH2(HERG) gene: identification and characterization of a novel mutation Y667X associated with long QT syndrome and a non-pathological 9 bp insertion.
Human mutation 2000;15(5):483.
2000: BJ Francken; Katty Josson; P Lijnen; Mirek Jurzak; Walter H M L Luyten; Josée E Leysen
Human 5-hydroxytryptamine(5A) receptors activate coexpressed G(i) and G(o) proteins in Spodoptera frugiperda 9 cells.
Molecular pharmacology 2000;57(5):1034-44.
2000: Marianne D De Backer; Ronald de Hoogt; G Froyen; F C Odds; F Simons; Roland Contreras; Walter H M L Luyten
Single allele knock-out of Candida albicans CGT1 leads to unexpected resistance to hygromycin B and elevated temperature.
Microbiology (Reading, England) 2000;146 ( Pt 2)():353-65.
2000: Eckhard Bender; Armelle Pindon; I van Oers; Y B Zhang; W Gommeren; Peter Verhasselt; Mirek Jurzak; Josée E Leysen; Walter H M L Luyten
Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.
Journal of neurochemistry 2000;74(2):478-89.
1999: Marianne D De Backer; D Maes; S Vandoninck; M Logghe; Roland Contreras; Walter H M L Luyten
Transformation of Candida albicans by electroporation.
Yeast (Chichester, England) 1999;15(15):1609-18.
1999: Patrick Marichal; L Koymans; S Willemsens; D Bellens; Peter Verhasselt; Walter H M L Luyten; Marcel Borgers; F C Ramaekers; Frank C Odds; H V Bossche
Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans.
Microbiology (Reading, England) 1999;145 ( Pt 10)():2701-13.
1999: JF Vanhauwe; N Fraeyman; BJ Francken; Walter H M L Luyten; Josée E Leysen
Comparison of the ligand binding and signaling properties of human dopamine D(2) and D(3) receptors in Chinese hamster ovary cells.
The Journal of pharmacology and experimental therapeutics 1999;290(2):908-16.
1999: Pascal Bonaventure; Lieve Umans; Margot H Bakker; P Cras; Xavier Langlois; Walter H M L Luyten; Anton Megens; Lutgarde Serneels; Fred Van Leuven; Josée E Leysen
Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization.
Molecular pharmacology 1999;56(1):54-67.
1999: A Blasina; I V de Weyer; MC Laus; Walter H M L Luyten; AE Parker; Clare H McGowan
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase.
Current biology : CB 1999;9(1):1-10.
1998: Peter Vanhoenacker; I Van den Bogerd; W Gommeren; Walter H M L Luyten; Josée E Leysen; Guy Haegeman
Efficient expression of neurotransmitter receptors in mammalian cells: use of inducible expression systems.
Annals of the New York Academy of Sciences 1998;861():236-7.
1998: BJ Francken; Mirek Jurzak; JF Vanhauwe; Walter H M L Luyten; Josée E Leysen
The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells.
European journal of pharmacology 1998;361(2-3):299-309.
1998: Marianne D De Backer; I Loonen; Peter Verhasselt; Jean-Marc Neefs; Walter H M L Luyten
Structure of the human histamine H1 receptor gene.
The Biochemical journal 1998;335 ( Pt 3)():663-70.
1998: AE Parker; Inez Van de Weyer; MC Laus; Peter Verhasselt; Walter H M L Luyten
Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene.
The Journal of biological chemistry 1998;273(29):18340-6.
1998: AE Parker; Inez Van de Weyer; MC Laus; I Oostveen; Jeff Yon; Peter Verhasselt; Walter H M L Luyten
A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease.
The Journal of biological chemistry 1998;273(29):18332-9.
1998: Ilse Van den Wyngaert; Jörg Sprengel; Stefan U Kass; Walter H M L Luyten
Cloning and analysis of a novel human putative DNA methyltransferase.
FEBS letters 1998;426(2):283-9.
1998: Anne Lesage; Ria Wouters; Paul van Gompel; Lieve I Heylen; Peter Vanhoenacker; Guy Haegeman; Walter H M L Luyten; Josée E Leysen
Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines.
British journal of pharmacology 1998;123(8):1655-65.
1998: Pascal Bonaventure; Pieter Voorn; Walter H M L Luyten; Josée E Leysen
5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion.
Neuroreport 1998;9(4):641-5.
1998: Pascal Bonaventure; Pieter Voorn; Walter H M L Luyten; Mirek Jurzak; A Schotte; Josée E Leysen
Detailed mapping of serotonin 5-HT1B and 5-HT1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function.
Neuroscience 1998;82(2):469-84.
1997: Ilse Van den Wyngaert; W Gommeren; Peter Verhasselt; Mirek Jurzak; Josée E Leysen; Walter H M L Luyten; Eckhard Bender
Cloning and expression of a human serotonin 5-HT4 receptor cDNA.
Journal of neurochemistry 1997;69(5):1810-9.
1997: Peter Vanhoenacker; W Gommeren; Walter H M L Luyten; Josée E Leysen; Guy Haegeman
Stable, high-level expression of human serotonin receptors in L929 cells using an inducible expression system.
Receptors & channels 1997;5(3-4):125-37.
1996: Josée E Leysen; W Gommeren; L Heylen; Walter H M L Luyten; Inez Van de Weyer; Peter Vanhoenacker; Guy Haegeman; A Schotte; P Van Gompel; R Wouters; A S Lesage
Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan.
Molecular pharmacology 1996;50(6):1567-80.
1996: A Schotte; P F Janssen; W Gommeren; Walter H M L Luyten; P Van Gompel; A S Lesage; K De Loore; Josée E Leysen
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.
Psychopharmacology 1996;124(1-2):57-73.
1993: Marianne D De Backer; W Gommeren; H Moereels; G Nobels; P Van Gompel; Josée E Leysen; Walter H M L Luyten
Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor.
Biochemical and biophysical research communications 1993;197(3):1601-8.
1993: Walter H M L Luyten; Josée E Leysen
Receptor cloning and heterologous expression--towards a new tool for drug discovery.
Trends in biotechnology 1993;11(6):247-54.
1993: Josée E Leysen; W Gommeren; J Mertens; Walter H M L Luyten; Petrus J Pauwels; M Ewert; P Seeburg
Comparison of in vitro binding properties of a series of dopamine antagonists and agonists for cloned human dopamine D2S and D2L receptors and for D2 receptors in rat striatal and mesolimbic tissues, using [125I] 2'-iodospiperone.
Psychopharmacology 1993;110(1-2):27-36.
1993: Josée E Leysen; P M Janssen; A Schotte; Walter H M L Luyten; Anton Megens
Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors.
Psychopharmacology 1993;112(1 Suppl):S40-54.
1992: A Schotte; P F Janssen; W Gommeren; Walter H M L Luyten; Josée E Leysen
Autoradiographic evidence for the occlusion of rat brain dopamine D3 receptors in vivo.
European journal of pharmacology 1992;218(2-3):373-5.