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Lucio Luzzatto

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Lucia Gargiulo; Aristeidis Chaidos; Josu de la Fuente; Mark Layton; Lucio Luzzatto; Cristina Nativi; Andrei V Nikolaev; Rosario Notaro; Mary Papaioannou; Barbara Richichi; Irene Roberts; Michela Sica; Giulia Talini; Anastasios Karadimitris
Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria.
David J Araten; Farid Boulad; Hugo Castro-Malaspina; Sara Chaffee; Jason Gonsky; Nancy A Kernan; Heather Magnan; Rosario Notaro; Susan E Prockop; Andromachi Scaradavou; Trudy Small; Roberto Tarquini; Howard T Thaler; Raymond Thertulien; Lucio Luzzatto
Thrombolytic therapy is effective in paroxysmal nocturnal hemoglobinuria: a series of nine patients and a review of the literature.
Andrea Lunardi; Lucio Luzzatto; Pier Giuseppe Pelicci; R Rivi; Leonardo Salmena; Michael Antoniou; Marina Botto; Anne Bygrave; Carlos Cordon-Cardo; Dubravka Drabek; Elaine Dzierzak; Marta Fagioli; Mirella Gaboli; Marco Giorgio; Frank Grosveld; Pier Paolo Pandolfi
A Role for PML in Innate Immunity.

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All Publications

2013: Lucia Gargiulo; Aristeidis Chaidos; Josu de la Fuente; Mark Layton; Lucio Luzzatto; Cristina Nativi; Andrei V Nikolaev; Rosario Notaro; Mary Papaioannou; Barbara Richichi; Irene Roberts; Michela Sica; Giulia Talini; Anastasios Karadimitris
Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria.
Blood 2013;121(14):2753-61.
2012: David J Araten; Farid Boulad; Hugo Castro-Malaspina; Sara Chaffee; Jason Gonsky; Nancy A Kernan; Heather Magnan; Rosario Notaro; Susan E Prockop; Andromachi Scaradavou; Trudy Small; Roberto Tarquini; Howard T Thaler; Raymond Thertulien; Lucio Luzzatto
Thrombolytic therapy is effective in paroxysmal nocturnal hemoglobinuria: a series of nine patients and a review of the literature.
Haematologica 2012;97(3):344-52.
2011: Andrea Lunardi; Lucio Luzzatto; Pier Giuseppe Pelicci; R Rivi; Leonardo Salmena; Michael Antoniou; Marina Botto; Anne Bygrave; Carlos Cordon-Cardo; Dubravka Drabek; Elaine Dzierzak; Marta Fagioli; Mirella Gaboli; Marco Giorgio; Frank Grosveld; Pier Paolo Pandolfi
A Role for PML in Innate Immunity.
Genes & cancer 2011;2(1):10-9.
2010: Benedetta Peruzzi; David J Araten; Rosario Notaro; Lucio Luzzatto
The use of PIG-A as a sentinel gene for the study of the somatic mutation rate and of mutagenic agents in vivo.
Mutation research 2010;705(1):3-10.
2009: Takahiro Maeda; Keisuke Ito; Taha Merghoub; Laura Poliseno; Robin M Hobbs; Guocan Wang; Lin Dong; Manami Maeda; Lou Dore; Arthur Zelent; Lucio Luzzatto; Julie T Feldstein; Mitchell J Weiss; Pier Paolo Pandolfi
LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis.
Developmental cell 2009;17(4):527-40.
2008: David Dingli; Lucio Luzzatto; Jorge Pacheco
Neutral evolution in paroxysmal nocturnal hemoglobinuria.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18496-500.
2008: Maria Luisa Lombardi; Giuseppe Terrazzano; Elena Cosentini; Lucia Gargiulo; Antonio Risitano; Rosa Camerlingo; Michela Sica; Daniela Aufiero; Alessandro Poggi; Giuseppe Pirozzi; Lucio Luzzatto; Bruno Rotoli; Rosario Notaro; Fiorella Alfinito; Giuseppina Ruggiero
Paroxysmal nocturnal hemoglobinuria: significant association with specific HLA-A, -B, -C, and -DR alleles in an Italian population.
Human immunology 2008;69(3):202-6.
2007: Peter Hillmen; Petra Muus; Ulrich Dührsen; Antonio M Risitano; Jörg Schubert; Lucio Luzzatto; Hubert Schrezenmeier; Jeff Szer; Robert A Brodsky; Anita Hill; Gérard Socié; Monica Bessler; Scott A Rollins; Leonard Bell; Russell P Rother; Neal S Young
Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria.
Blood 2007;110(12):4123-8.
2007: Lucia Gargiulo; Sonia Lastraioli; Giannamaria Cerruti; Martina Serra; Fabrizio Loiacono; Simona Zupo; Lucio Luzzatto; Rosario Notaro
Highly homologous T-cell receptor beta sequences support a common target for autoreactive T cells in most patients with paroxysmal nocturnal hemoglobinuria.
Blood 2007;109(11):5036-42.
2007: Lucio Luzzatto
Inherited and acquired mutations in blood diseases.
Lijec̆nic̆ki vjesnik 2007;129 Suppl 3():35-6.
2006: Erika Ortolan; Elena V Tibaldi; Bruna Ferranti; Luisa Lavagno; Giovanni Garbarino; Rosario Notaro; Lucio Luzzatto; Fabio Malavasi; Ada Funaro
CD157 plays a pivotal role in neutrophil transendothelial migration.
Blood 2006;108(13):4214-22.
2006: Peter Hillmen; Neal S Young; Jörg Schubert; Robert A Brodsky; Gérard Socié; Petra Muus; Alexander Röth; Jeff Szer; Modupe Elebute; Ryotaro Nakamura; Paul Browne; Antonio M Risitano; Anita Hill; Hubert Schrezenmeier; Chieh-Lin Fu; Jaroslaw Maciejewski; Scott A Rollins; Christopher F Mojcik; Russell P Rother; Lucio Luzzatto
The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria.
The New England journal of medicine 2006;355(12):1233-43.
2006: David J Araten; Lucio Luzzatto
The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH).
Blood 2006;108(2):734-6.
2005: Alessandro Poggi; Simone Negrini; Maria Raffaella Zocchi; Anna-Maria Massaro; Lucia Garbarino; Sonia Lastraioli; Lucia Gargiulo; Lucio Luzzatto; Rosario Notaro
Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors.
Blood 2005;106(7):2399-408.
2005: David J Araten; David W Golde; Rong H Zhang; Howard T Thaler; Lucia Gargiulo; Rosario Notaro; Lucio Luzzatto
A quantitative measurement of the human somatic mutation rate.
Cancer research 2005;65(18):8111-7.
2005: David J Araten; Howard T Thaler; Lucio Luzzatto
High incidence of thrombosis in African-American and Latin-American patients with Paroxysmal Nocturnal Haemoglobinuria.
Thrombosis and haemostasis 2005;93(1):88-91.
2004: Ada Funaro; Erika Ortolan; Bruna Ferranti; Lucia Gargiulo; Rosario Notaro; Lucio Luzzatto; Fabio Malavasi
CD157 is an important mediator of neutrophil adhesion and migration.
Blood 2004;104(13):4269-78.
2004: Patricia A Shi; Maria De Angioletti; Robert E Donahue; Rosario Notaro; Lucio Luzzatto; Cynthia E Dunbar
In vivo gene marking of rhesus macaque long-term repopulating hematopoietic cells using a VSV-G pseudotyped versus amphotropic oncoretroviral vector.
The journal of gene medicine 2004;6(4):367-73.
2003: Anastasios Karadimitris; David J Araten; Lucio Luzzatto; Rosario Notaro
Severe telomere shortening in patients with paroxysmal nocturnal hemoglobinuria affects both GPI- and GPI+ hematopoiesis.
Blood 2003;102(2):514-6.
2002: David J Araten; Monica Bessler; S McKenzie; Hugo Castro-Malaspina; Barrett H Childs; Farid Boulad; Anastasios Karadimitris; Rosario Notaro; Lucio Luzzatto
Dynamics of hematopoiesis in paroxysmal nocturnal hemoglobinuria (PNH): no evidence for intrinsic growth advantage of PNH clones.
Leukemia 2002;16(11):2243-8.
2002: Monica Bessler; Vittorio Rosti; Yufeng Peng; Giorgio Cattoretti; Rosario Notaro; Satomi Ohsako; Keith B Elkon; Lucio Luzzatto
Glycosylphosphatidylinositol-linked proteins are required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.
European journal of immunology 2002;32(9):2607-16.
2002: Letizia Longo; Olga Camacho Vanegas; Meghavi Patel; Vittorio Rosti; Haiqing Li; John Waka; Taha Merghoub; Pier Paolo Pandolfi; Rosario Notaro; Katia Manova-Todorova; Lucio Luzzatto
Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal.
The EMBO journal 2002;21(16):4229-39.
2002: Maria De Angioletti; Ana Rovira; Michel Sadelain; Lucio Luzzatto; Rosario Notaro
Frequency of missense mutations in the coding region of a eukaryotic gene transferred by retroviral vectors.
Journal of virology 2002;76(4):1991-4.
2001: Anastasios Karadimitris; K Li; Rosario Notaro; David J Araten; Khedoudja Nafa; R Thertulien; Marc Ladanyi; A E Stevens; C S Rosenfeld; Irene A G Roberts; Lucio Luzzatto
Association of clonal T-cell large granular lymphocyte disease and paroxysmal nocturnal haemoglobinuria (PNH): further evidence for a pathogenetic link between T cells, aplastic anaemia and PNH.
British journal of haematology 2001;115(4):1010-4.
2001: David J Araten; D Swirsky; Anastasios Karadimitris; Rosario Notaro; Khedoudja Nafa; Monica Bessler; Howard T Thaler; Hugo Castro-Malaspina; Barrett H Childs; Farid Boulad; M Weiss; N Anagnostopoulos; Abdullah Kutlar; D G Savage; Richard T Maziarz; Suresh C Jhanwar; Lucio Luzzatto
Cytogenetic and morphological abnormalities in paroxysmal nocturnal haemoglobinuria.
British journal of haematology 2001;115(2):360-8.
2001: Anastasios Karadimitris; Lucio Luzzatto
The cellular pathogenesis of paroxysmal nocturnal haemoglobinuria.
Leukemia 2001;15(8):1148-52.
2001: Maria De Angioletti; Ana Rovira; Rosario Notaro; O Camacho Vanegas; Michel Sadelain; Lucio Luzzatto
Glucose 6-phosphate dehydrogenase expression is less prone to variegation when driven by its own promoter.
Gene 2001;267(2):221-31.
2001: Anastasios Karadimitris; Stephan D Gadola; M Altamirano; D Brown; A Woolfson; Paul Klenerman; J L Chen; Y Koezuka; Irene A G Roberts; David A Price; Geoffrey Dusheiko; César Milstein; Alan Fersht; Lucio Luzzatto; Vincenzo Cerundolo
Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3294-8.
2000: Ana Rovira; Maria De Angioletti; O Camacho-Vanegas; D Liu; Vittorio Rosti; Humilidad F Gallardo; Rosario Notaro; Michel Sadelain; Lucio Luzzatto
Stable in vivo expression of glucose-6-phosphate dehydrogenase (G6PD) and rescue of G6PD deficiency in stem cells by gene transfer.
Blood 2000;96(13):4111-7.
2000: Anastasios Karadimitris; Rosario Notaro; Guenther Koehne; Irene A G Roberts; Lucio Luzzatto
PNH cells are as sensitive to T-cell-mediated lysis as their normal counterparts: implications for the pathogenesis of paroxysmal nocturnal haemoglobinuria.
British journal of haematology 2000;111(4):1158-63.
2000: Anastasios Karadimitris; John Manavalan; Howard T Thaler; Rosario Notaro; David J Araten; Khedoudja Nafa; Irene A G Roberts; Marc E Weksler; Lucio Luzzatto
Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria.
Blood 2000;96(7):2613-20.
2000: Lucio Luzzatto
Cloning, clones and clonal disease.
Journal of the Royal College of Physicians of London 2000;34(5):461-3.
2000: Rosario Notaro; A Afolayan; Lucio Luzzatto
Human mutations in glucose 6-phosphate dehydrogenase reflect evolutionary history.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(3):485-94.
2000: David J Araten; Lucio Luzzatto
Allogeneic bone marrow transplantation for paroxysmal nocturnal hemoglobinuria.
Haematologica 2000;85(1):1-2.
1999: Carole Oddoux; E Guillen-Navarro; C Ditivoli; E Dicave; M R Cilio; CM Clayton; H Nelson; Kyriakie Sarafoglou; N McCain; H Peretz; U Seligsohn; Lucio Luzzatto; Khedoudja Nafa; Michael A Nardi; M Karpatkin; Ivona Aksentijevich; Daniel Kastner; Felicia B Axelrod; Harry Ostrer
Mendelian diseases among Roman Jews: implications for the origins of disease alleles.
The Journal of clinical endocrinology and metabolism 1999;84(12):4405-9.
1999: Boris Pasche; Prema Kolachana; Khedoudja Nafa; Jaya M Satagopan; YG Chen; RS Lo; D Brener; D Yang; L Kirstein; Carole Oddoux; Harry Ostrer; Paolo Vineis; L Varesco; Suresh C Jhanwar; Lucio Luzzatto; Joan Massagué; Kenneth Offit
TbetaR-I(6A) is a candidate tumor susceptibility allele.
Cancer research 1999;59(22):5678-82.
1999: Lucio Luzzatto
Paroxysmal murine Hemoglobinuria(?): A model for human PNH.
Blood 1999;94(9):2941-4.
1999: David J Araten; Khedoudja Nafa; K Pakdeesuwan; Lucio Luzzatto
Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):5209-14.
1998: Khedoudja Nafa; Monica Bessler; H Joachim Deeg; Lucio Luzzatto
New somatic mutation in the PIG-A gene emerges at relapse of paroxysmal nocturnal hemoglobinuria.
Blood 1998;92(9):3422-7.
1998: M Cappadoro; Giuliana Giribaldi; E O'Brien; Franco Turrini; Franca Mannu; Daniela Ulliers; G Simula; Lucio Luzzatto; Paolo Arese
Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency.
Blood 1998;92(7):2527-34.
1998: Khedoudja Nafa; Monica Bessler; Hugo Castro-Malaspina; Suresh C Jhanwar; Lucio Luzzatto
The spectrum of somatic mutations in the PIG-A gene in paroxysmal nocturnal hemoglobinuria includes large deletions and small duplications.
Blood cells, molecules & diseases 1998;24(3):370-84.
1998: Boris Pasche; Y Luo; Pulivarthi H Rao; Stephen D Nimer; Ethan Dmitrovsky; P Caron; Lucio Luzzatto; Kenneth Offit; Carlos Cordon-Cardo; B Renault; Jaya M Satagopan; Vundavalli Murty; Joan Massagué
Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract.
Cancer research 1998;58(13):2727-32.
1997: Rosario Notaro; A Cimmino; D Tabarini; B Rotoli; Lucio Luzzatto
In vivo telomere dynamics of human hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13782-5.
1997: Lucio Luzzatto
Somatic mutation in paroxysmal nocturnal hemoglobinuria.
Hospital practice (1995) 1997;32(9):125-31, 135-6, 139-40.
1997: Vittorio Rosti; G Tremml; V da C Soares; Pier Paolo Pandolfi; Lucio Luzzatto; Monica Bessler
Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion.
The Journal of clinical investigation 1997;100(5):1028-36.
1997: T Bulliamy; Lucio Luzzatto; A Hirono; E Beutler
Hematologically important mutations: glucose-6-phosphate dehydrogenase.
Blood cells, molecules & diseases 1997;23(2):302-13.
1997: Lucio Luzzatto; Monica Bessler; B Rotoli
Somatic mutations in paroxysmal nocturnal hemoglobinuria: a blessing in disguise?
Cell 1997;88(1):1-4.
1996: Khedoudja Nafa; Monica Bessler; P Mason; T Vulliamy; Peter Hillmen; Hugo Castro-Malaspina; Lucio Luzzatto
Factor V Leiden mutation investigated by amplification created restriction enzyme site (ACRES) in PNH patients with and without thrombosis.
Haematologica 1996;81(6):540-2.
1996: Silvana Filosa; N Giacometti; C Wangwei; D De Mattia; D Pagnini; Fiorella Alfinito; F Schettini; Lucio Luzzatto; G Martini
Somatic-cell selection is a major determinant of the blood-cell phenotype in heterozygotes for glucose-6-phosphate dehydrogenase mutations causing severe enzyme deficiency.
American journal of human genetics 1996;59(4):887-95.
1996: C M Corcoran; P Fraser; G Martini; Lucio Luzzatto; Philip J Mason
High-level regulated expression of the human G6PD gene in transgenic mice.
Gene 1996;173(2):241-6.
1996: Shahina Daar; Tom Vulliamy; Jaspal Kaeda; Philip J Mason; Lucio Luzzatto
Molecular characterization of G6PD deficiency in Oman.
Human heredity 1996;46(3):172-6.
1996: Riad Bayoumi; MS Nur-E-Kamal; M Tadayyon; K K Mohamed; B H Mahboob; MM Qureshi; M S Lakhani; M O Awaad; Jaspal Kaeda; Tom Vulliamy; Lucio Luzzatto
Molecular characterization of erythrocyte glucose-6-phosphate dehydrogenase deficiency in Al-Ain District, United Arab Emirates.
Human heredity 1996;46(3):136-41.
1996: K Konstantopoulos; Tom Vulliamy; D Swirsky; J D Reeves; Jaspal Kaeda; Lucio Luzzatto
DNA haplotypes in Africans and West Indians with sickle cell anaemia or SC disease.
Gene geography : a computerized bulletin on human gene frequencies 1996;10(1):19-24.
1996: Lucio Luzzatto; Monica Bessler
The dual pathogenesis of paroxysmal nocturnal hemoglobinuria.
Current opinion in hematology 1996;3(2):101-10.
1996: Mary Frances McMullin; Peter Hillmen; G E Elder; Terence R J Lappin; Lucio Luzzatto
Serum erythropoietin levels in paroxysmal nocturnal haemoglobinuria: implications for therapy.
British journal of haematology 1996;92(4):815-7.
1996: Tom Vulliamy; A Rovira; N Yusoff; D Colomer; Lucio Luzzatto; J L Vives-Corrons
Independent origin of single and double mutations in the human glucose 6-phosphate dehydrogenase gene.
Human mutation 1996;8(4):311-8.
1995: Khedoudja Nafa; Philip J Mason; Peter Hillmen; Lucio Luzzatto; Monica Bessler
Mutations in the PIG-A gene causing paroxysmal nocturnal hemoglobinuria are mainly of the frameshift type.
Blood 1995;86(12):4650-5.
1995: Jaspal Kaeda; G P Chhotray; M R Ranjit; José M Bautista; P Hemachandra Reddy; D Stevens; J M Naidu; R P Britt; Tom Vulliamy; Lucio Luzzatto
A new glucose-6-phosphate dehydrogenase variant, G6PD Orissa (44 Ala-->Gly), is the major polymorphic variant in tribal populations in India.
American journal of human genetics 1995;57(6):1335-41.
1995: Peter Hillmen; S M Lewis; Monica Bessler; Lucio Luzzatto; J V Dacie
Natural history of paroxysmal nocturnal hemoglobinuria.
The New England journal of medicine 1995;333(19):1253-8.
1995: Pier Paolo Pandolfi; F Sonati; R Rivi; P Mason; F Grosveld; Lucio Luzzatto
Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress.
The EMBO journal 1995;14(21):5209-15.
1995: P Srivastava; Jaspal Kaeda; D Roper; Tom Vulliamy; M Buckley; Lucio Luzzatto
Severe hemolytic anemia associated with the homozygous state for an unstable hemoglobin variant (Hb Bushwick).
Blood 1995;86(5):1977-82.
1995: José M Bautista; Philip J Mason; Lucio Luzzatto
Human glucose-6-phosphate dehydrogenase. Lysine 205 is dispensable for substrate binding but essential for catalysis.
FEBS letters 1995;366(1):61-4.
1995: Philip J Mason; D J Stevens; Lucio Luzzatto; Sydney Brenner; S Aparicio
Genomic structure and sequence of the Fugu rubripes glucose-6-phosphate dehydrogenase gene (G6PD).
Genomics 1995;26(3):587-91.
1995: Lucio Luzzatto
About hemoglobins, G6PD and parasites in red cells.
Experientia 1995;51(3):206-8.
1995: M Ganczakowski; M Town; DK Bowden; Tom Vulliamy; A Kaneko; John B Clegg; David J Weatherall; Lucio Luzzatto
Multiple glucose 6-phosphate dehydrogenase-deficient variants correlate with malaria endemicity in the Vanuatu archipelago (southwestern Pacific).
American journal of human genetics 1995;56(1):294-301.
1994: Khedoudja Nafa; Abderrezak Reghis; N Osmani; L Baghli; H Aït-Abbes; M Benabadji; J C Kaplan; T Vulliamy; Lucio Luzzatto
At least five polymorphic mutants account for the prevalence of glucose-6-phosphate dehydrogenase deficiency in Algeria.
Human genetics 1994;94(5):513-7.
1994: Jaspal Kaeda; K Prasad; R J Howard; A Mehta; Tom Vulliamy; Lucio Luzzatto
Management of pregnancy when maternal blood has a very high level of fetal haemoglobin.
British journal of haematology 1994;88(2):432-4.
1994: Inderjeet Dokal; Lucio Luzzatto
Dyskeratosis congenita is a chromosomal instability disorder.
Leukemia & lymphoma 1994;15(1-2):1-7.
1994: Monica Bessler; Philip J Mason; Peter Hillmen; Lucio Luzzatto
Mutations in the PIG-A gene causing partial deficiency of GPI-linked surface proteins (PNH II) in patients with paroxysmal nocturnal haemoglobinuria.
British journal of haematology 1994;87(4):863-6.
1994: S D Wagner; V Martinelli; Lucio Luzzatto
Similar patterns of V kappa gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma.
Blood 1994;83(12):3647-53.
1994: L Longo; Monica Bessler; P Beris; D Swirsky; Lucio Luzzatto
Myelodysplasia in a patient with pre-existing paroxysmal nocturnal haemoglobinuria: a clonal disease originating from within a clonal disease.
British journal of haematology 1994;87(2):401-3.
1994: Monica Bessler; Peter Hillmen; L Longo; Lucio Luzzatto; Philip J Mason
Genomic organization of the X-linked gene (PIG-A) that is mutated in paroxysmal nocturnal haemoglobinuria and of a related autosomal pseudogene mapped to 12q21.
Human molecular genetics 1994;3(5):751-7.
1994: Monica Bessler; P Mason; Peter Hillmen; Lucio Luzzatto
Somatic mutations and cellular selection in paroxysmal nocturnal haemoglobinuria.
Lancet 1994;343(8903):951-3.
1994: E O'Brien; B Kurdi-Haidar; W Wanachiwanawin; J L Carvajal; Tom Vulliamy; M Cappadoro; Philip J Mason; Lucio Luzzatto
Cloning of the glucose 6-phosphate dehydrogenase gene from Plasmodium falciparum.
Molecular and biochemical parasitology 1994;64(2):313-26.
1994: Monica Bessler; Philip J Mason; Peter Hillmen; T Miyata; N Yamada; J Takeda; Lucio Luzzatto; T Kinoshita
Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene.
The EMBO journal 1994;13(1):110-7.
1994: Mary Frances McMullin; Peter Hillmen; J Jackson; P Ganly; Lucio Luzzatto
Tissue plasminogen activator for hepatic vein thrombosis in paroxysmal nocturnal haemoglobinuria.
Journal of internal medicine 1994;235(1):85-9.
1993: Silvana Filosa; V Calabrò; G Lania; Tom Vulliamy; Carlo Brancati; Antonio Tagarelli; Lucio Luzzatto; G Martini
G6PD haplotypes spanning Xq28 from F8C to red/green color vision.
Genomics 1993;17(1):6-14.
1993: Peter Hillmen; Monica Bessler; Philip J Mason; W M Watkins; Lucio Luzzatto
Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5272-6.
1993: Peter Hillmen; Monica Bessler; J Bungey; Lucio Luzzatto
Paroxysmal nocturnal hemoglobinuria: correction of abnormal phenotype by somatic cell hybridization.
Somatic cell and molecular genetics 1993;19(2):123-9.
1993: V Calabrò; Philip J Mason; Silvana Filosa; Donatella Civitelli; Rita Cittadella; Antonio Tagarelli; G Martini; Carlo Brancati; Lucio Luzzatto
Genetic heterogeneity of glucose-6-phosphate dehydrogenase deficiency revealed by single-strand conformation and sequence analysis.
American journal of human genetics 1993;52(3):527-36.
1993: S D Wagner; Lucio Luzzatto
V kappa gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the V kappa locus and do not show somatic mutation.
European journal of immunology 1993;23(2):391-7.
1993: Khedoudja Nafa; Abderrezak Reghis; N Osmani; L Baghli; M Benabadji; J C Kaplan; T J Vulliamy; Lucio Luzzatto
G6PD Aures: a new mutation (48 Ile-->Thr) causing mild G6PD deficiency is associated with favism.
Human molecular genetics 1993;2(1):81-2.
1993: Tom Vulliamy; E Beutler; Lucio Luzzatto
Variants of glucose-6-phosphate dehydrogenase are due to missense mutations spread throughout the coding region of the gene.
Human mutation 1993;2(3):159-67.
1993: Peter Hillmen; Monica Bessler; D H Crawford; Lucio Luzzatto
Production and characterization of lymphoblastoid cell lines with the paroxysmal nocturnal hemoglobinuria phenotype.
Blood 1993;81(1):193-9.
1992: Inderjeet Dokal; J Bungey; P Williamson; D Oscier; J Hows; Lucio Luzzatto
Dyskeratosis congenita fibroblasts are abnormal and have unbalanced chromosomal rearrangements.
Blood 1992;80(12):3090-6.
1992: Michael A Laffan; Lucio Luzzatto
Anomalous rearrangements of the immunoglobulin heavy chain genes in human leukemias support the loop-out mechanism of class switch.
The Journal of clinical investigation 1992;90(6):2299-303.
1992: Monica Bessler; Peter Hillmen; Lucio Luzzatto
Clonal origin of abnormal granulocytes in paroxysmal nocturnal hemoglobinuria.
Blood 1992;80(3):844-5.
1992: A Ahluwalia; C M Corcoran; Tom Vulliamy; C S Ishwad; J M Naidu; A Argusti; D J Stevens; Philip J Mason; Lucio Luzzatto
G6PD Kalyan and G6PD Kerala; two deficient variants in India caused by the same 317 Glu-->Lys mutation.
Human molecular genetics 1992;1(3):209-10.
1992: M Town; José M Bautista; Philip J Mason; Lucio Luzzatto
Both mutations in G6PD A- are necessary to produce the G6PD deficient phenotype.
Human molecular genetics 1992;1(3):171-4.
1992: Tom Vulliamy; P Mason; Lucio Luzzatto
The molecular basis of glucose-6-phosphate dehydrogenase deficiency.
Trends in genetics : TIG 1992;8(4):138-43.
1992: C M Corcoran; V Calabrò; G Tamagnini; M Town; B Haidar; Tom Vulliamy; Philip J Mason; Lucio Luzzatto
Molecular heterogeneity underlying the G6PD Mediterranean phenotype.
Human genetics 1992;88(6):688-90.
1992: Peter Hillmen; Jill M Hows; Lucio Luzzatto
Two distinct patterns of glycosylphosphatidylinositol (GPI) linked protein deficiency in the red cells of patients with paroxysmal nocturnal haemoglobinuria.
British journal of haematology 1992;80(3):399-405.
1992: José M Bautista; Philip J Mason; Lucio Luzzatto
Purification and properties of human glucose-6-phosphate dehydrogenase made in E. coli.
Biochimica et biophysica acta 1992;1119(1):74-80.
1992: Lucio Luzzatto
Gene transfer and gene therapy.
Journal of internal medicine 1992;231(1):3-6.
1992: Silvana Filosa; V Calabrò; D Vallone; V Poggi; P Mason; D Pagnini; Fiorella Alfinito; Bruno Rotoli; G Martini; Lucio Luzzatto
Molecular basis of chronic non-spherocytic haemolytic anaemia: a new G6PD variant (393 Arg----His) with abnormal KmG6P and marked in vivo instability.
British journal of haematology 1992;80(1):111-6.
1991: Tom Vulliamy; A Othman; M Town; A Nathwani; A G Falusi; Philip J Mason; Lucio Luzzatto
Polymorphic sites in the African population detected by sequence analysis of the glucose-6-phosphate dehydrogenase gene outline the evolution of the variants A and A-.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8568-71.
1991: Sean J Whittaker; N P Smith; R R Jones; Lucio Luzzatto
Analysis of beta, gamma, and delta T-cell receptor genes in mycosis fungoides and Sezary syndrome.
Cancer 1991;68(7):1572-82.
1991: C Hoyle; J Kaeda; J Leslie; Lucio Luzzatto
Acquired beta thalassaemia trait in MDS.
British journal of haematology 1991;79(1):116-7.
1991: S Whittaker; N Smith; R R Jones; Lucio Luzzatto
Analysis of beta, gamma, and delta T-cell receptor genes in lymphomatoid papulosis: cellular basis of two distinct histologic subsets.
The Journal of investigative dermatology 1991;96(5):786-91.
1991: Tom Vulliamy; A Othman; M Town; A Nathwani; Y Falusi; Lucio Luzzatto
Linkage disequilibrium of polymorphic sites in the G6PD gene in African populations and the origin of G6PD A-.
Gene geography : a computerized bulletin on human gene frequencies 1991;5(1-2):13-21.
1991: Lucio Luzzatto
In memoriam P.K. Sukumaran 1920-1990.
Hemoglobin 1991;15(5):v-vii.
1990: D J Stevens; W Wanachiwanawin; Philip J Mason; Tom Vulliamy; Lucio Luzzatto
G6PD Canton a common deficient variant in South East Asia caused by a 459 Arg----Leu mutation.
Nucleic acids research 1990;18(23):7190.
1990: B Kurdi-Haidar; Philip J Mason; A Berrebi; G Ankra-Badu; A al-Ali; A Oppenheim; Lucio Luzzatto
Origin and spread of the glucose-6-phosphate dehydrogenase variant (G6PD-Mediterranean) in the Middle East.
American journal of human genetics 1990;47(6):1013-9.
1990: V Poggi; M Town; N S Foulkes; Lucio Luzzatto
Identification of a single base change in a new human mutant glucose-6-phosphate dehydrogenase gene by polymerase-chain-reaction amplification of the entire coding region from genomic DNA.
The Biochemical journal 1990;271(1):157-60.
1990: Philip J Mason; José M Bautista; Tom Vulliamy; N Turner; Lucio Luzzatto
Human red cell glucose-6-phosphate dehydrogenase is encoded only on the X chromosome.
Cell 1990;62(1):9-10.
1990: B Kurdi-Haidar; Lucio Luzzatto
Expression and characterization of glucose-6-phosphate dehydrogenase of Plasmodium falciparum.
Molecular and biochemical parasitology 1990;41(1):83-91.
1990: M F Fey; james wainscoat; E C Mukwala; A G Falusi; Tom Vulliamy; Lucio Luzzatto
A PvuII restriction fragment length polymorphism of the glucose-6-phosphate dehydrogenase gene is an African-specific marker.
Human genetics 1990;84(5):471-2.
1990: Lucio Luzzatto
Leukaemia is a genetic disorder of somatic cells.
Haematologica 1990;75(2):105-8.
1990: M Town; M Athanasiou-Metaxa; Lucio Luzzatto
Intragenic interspecific complementation of glucose 6-phosphate dehydrogenase in human-hamster cell hybrids.
Somatic cell and molecular genetics 1990;16(2):97-108.
1989: A B Mehta; Tom Vulliamy; E C Gordon-Smith; Lucio Luzzatto
A new genetic polymorphism in the 16S ribosomal RNA gene of human mitochondrial DNA.
Annals of human genetics 1989;53(Pt 4):303-10.
1989: Tom Vulliamy; W Wanachiwanawin; Philip J Mason; Lucio Luzzatto
G6PD mahidol, a common deficient variant in South East Asia is caused by a (163)glycine----serine mutation.
Nucleic acids research 1989;17(14):5868.
1989: A B Mehta; E Chiu; N Harhalakis; K Economou; L Foroni; Lucio Luzzatto; E C Gordon-Smith
A T-cell lymphoma of suppressor phenotype arising in a patient with severe aplastic anaemia.
British journal of haematology 1989;72(2):287-9.
1988: Philip J Mason; Tom Vulliamy; N S Foulkes; M Town; B Haidar; Lucio Luzzatto
The production of normal and variant human glucose-6-phosphate dehydrogenase in cos cells.
European journal of biochemistry / FEBS 1988;178(1):109-13.
1988: Junia V Melo; L Foroni; V Brito-Babapulle; Lucio Luzzatto; D Catovsky
The establishment of cell lines from chronic B cell leukaemias: evidence of leukaemic origin by karyotypic abnormalities and Ig gene rearrangement.
Clinical and experimental immunology 1988;73(1):23-8.
1988: N S Foulkes; P P Pandolfi de Rinaldis; J Macdonnell; Nicholas C P Cross; Lucio Luzzatto
Polymerase chain reaction automated at low cost.
Nucleic acids research 1988;16(12):5687-8.
1988: Feyruz V Rassool; L Foroni; Amin Rahemtulla; O Dreazen; LM Wiedemann; A P Guo; S Legon; D Catovsky; Lucio Luzzatto; J Goldman
The genomic breakpoint in a patient with Philadelphia-positive acute leukemia is 5' of the breakpoint cluster region.
Cancer genetics and cytogenetics 1988;32(2):217-27.
1988: L Foroni; E Matutes; J Foldi; R Morilla; T Rabbitts; Lucio Luzzatto; D Catovsky
T-cell leukemias with rearrangement of the gamma but not beta T-cell receptor genes.
Blood 1988;71(2):356-62.
1987: L Foroni; J Foldi; E Matutes; D Catovsky; N J O'Connor; R Baer; A Forster; T H Rabbitts; Lucio Luzzatto
Alpha, beta and gamma T-cell receptor genes: rearrangements correlate with haematological phenotype in T cell leukaemias.
British journal of haematology 1987;67(3):307-18.
1987: L Foroni; D Catovsky; Lucio Luzzatto
Immunoglobulin gene rearrangements in hairy cell leukemia and other chronic B cell lymphoproliferative disorders.
Leukemia 1987;1(4):389-92.
1987: E Matutes; L Foroni; S Amin; M P de Oliveira; V Brito-Babapulle; Lucio Luzzatto; D Catovsky
'Pseudo-lymphoid' leukaemia with unusual features: ultrastructural, immunological, cytogenetic and molecular studies.
European journal of haematology 1987;38(4):303-9.
1987: K H Th'ng; G Garewal; L Kearney; Feyruz V Rassool; J V Melo; H White; D Catovsky; L Foroni; Lucio Luzzatto; J M Goldman
Establishment and characterization of three new malignant lymphoid cell lines.
International journal of cancer. Journal international du cancer 1987;39(1):89-93.
1986: M S Pombo de Oliveira; F E Awad el Seed; L Foroni; E Matutes; R Morilla; Lucio Luzzatto; D Catovsky
Lymphoblastic leukaemia in Siamese twins: evidence for identity.
Lancet 1986;2(8513):969-70.
1986: Junia V Melo; V Brito-Babapulle; L Foroni; D S Robinson; Lucio Luzzatto; D Catovsky
Two new cell lines from B-prolymphocytic leukaemia: characterization by morphology, immunological markers, karyotype and Ig gene rearrangement.
International journal of cancer. Journal international du cancer 1986;38(4):531-8.
1985: Junia V Melo; L Foroni; V Brito Babapulle; D S Lewis; M Bennett; D Robinson; L Parreira; Lucio Luzzatto; D Catovsky
Prolymphocytic leukemia of B cell type: rearranged immunoglobulin (Ig) genes with defective Ig production.
Blood 1985;66(2):391-8.