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Nils Lycke

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P Bergqvist; L Hazanov; Anna Holmberg; J Mattsson; R Mehr; Anneli Stensson; Mats Bemark; Nils Lycke
Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responses.
Nils Lycke
Recent progress in mucosal vaccine development: potential and limitations.
Johan Mattsson; Jeffrey V Ravetch; Karin Schön; Anneli Stensson; Ulf Yrlid; Mikael C I Karlsson; Nils Lycke
Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

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2013: P Bergqvist; L Hazanov; Anna Holmberg; J Mattsson; R Mehr; Anneli Stensson; Mats Bemark; Nils Lycke
Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responses.
Mucosal immunology 2013;6(1):122-35.
2012: Nils Lycke
Recent progress in mucosal vaccine development: potential and limitations.
Nature reviews. Immunology 2012;12(8):592-605.
2011: Johan Mattsson; Jeffrey V Ravetch; Karin Schön; Anneli Stensson; Ulf Yrlid; Mikael C I Karlsson; Nils Lycke
Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3641-52.
2011: Dubravka Grdic Eliasson; Anja Helgeby; Karin Schön; Caroline Nygren; Karim El Bakkouri; Walter Fiers; Xavier Saelens; Karin Bengtsson Lövgren; Ida Nyström; Nils Lycke
A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus.
Vaccine 2011;29(23):3951-61.
2011: Mats Bemark; Peter Bergqvist; Anneli Stensson; Anna Holmberg; Johan Mattsson; Nils Lycke
A unique role of the cholera toxin A1-DD adjuvant for long-term plasma and memory B cell development.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1399-410.
2010: Nils Lycke
Is the choice of vaccine adjuvant critical for long-term memory development?
Expert review of vaccines 2010;9(12):1357-61.
2010: Nils Lycke; Mats Bemark
Mucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins.
Mucosal immunology 2010;3(6):556-66.
2010: Yu Fang; Lisa Larsson; Johan Mattsson; Nils Lycke; Zou Xiang
Mast cells contribute to the mucosal adjuvant effect of CTA1-DD after IgG-complex formation.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):2935-41.
2010: Peter Bergqvist; Anneli Stensson; Nils Lycke; Mats Bemark
T cell-independent IgA class switch recombination is restricted to the GALT and occurs prior to manifest germinal center formation.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3545-53.
2010: Annemarie Hasselberg; Lena Ekman; Linda Fahlén Yrlid; Karin Schön; Nils Lycke
ADP-ribosylation controls the outcome of tolerance or enhanced priming following mucosal immunization.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(6):2776-84.
2009: Annemarie Hasselberg; Karin Schön; Andrej Tarkowski; Nils Lycke
Role of CTA1R7K-COL-DD as a novel therapeutic mucosal tolerance-inducing vector for treatment of collagen-induced arthritis.
Arthritis and rheumatism 2009;60(6):1672-82.
2008: Dubravka Grdic Eliasson; Karim El Bakkouri; Karin Schön; Anna Ramne; Els Festjens; Björn Löwenadler; Walter Fiers; Xavier Saelens; Nils Lycke
CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.
Vaccine 2008;26(9):1243-52.
2007: Ellen Marks; Martina Verolin; Anneli Stensson; Nils Lycke
Differential CD28 and inducible costimulatory molecule signaling requirements for protective CD4+ T-cell-mediated immunity against genital tract Chlamydia trachomatis infection.
Infection and immunity 2007;75(9):4638-47.
2007: Monica M McNeal; Mitali Basu; Judy A Bean; John Clements; Nils Lycke; Anna Ramne; Björn Löwenadler; Anthony H-C Choi; Richard L Ward
Intrarectal immunization of mice with VP6 and either LT(R192G) or CTA1-DD as adjuvant protects against fecal rotavirus shedding after EDIM challenge.
Vaccine 2007;25(33):6224-31.
2007: Claire Swetman Andersen; Jes Dietrich; Else Marie Agger; Nils Lycke; Karin Lövgren; Peter Andersen
The combined CTA1-DD/ISCOMs vector is an effective intranasal adjuvant for boosting prior Mycobacterium bovis BCG immunity to Mycobacterium tuberculosis.
Infection and immunity 2007;75(1):408-16.
2006: Peter Bergqvist; Eva Gärdby; Anneli Stensson; Mats Bemark; Nils Lycke
Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7772-83.
2006: Marina De Filette; Walter Fiers; Wouter Martens; Ashley Birkett; Anna Ramne; Björn Löwenadler; Nils Lycke; Willy Min Jou; Xavier Saelens
Improved design and intranasal delivery of an M2e-based human influenza A vaccine.
Vaccine 2006;24(44-46):6597-601.
2006: Anja Helgeby; Neil C Robson; Anne M Donachie; Helen Beackock-Sharp; Karin Lövgren; Karin Schön; Allan McI Mowat; Nils Lycke
The combined CTA1-DD/ISCOM adjuvant vector promotes priming of mucosal and systemic immunity to incorporated antigens by specific targeting of B cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3697-706.
2006: Ali A Akhiani; Anneli Stensson; Karin Schön; Nils Lycke
The nontoxic CTA1-DD adjuvant enhances protective immunity against Helicobacter pylori infection following mucosal immunization.
Scandinavian journal of immunology 2006;63(2):97-105.
2006: Marina De Filette; Anna Ramne; Ashley Birkett; Nils Lycke; Björn Löwenadler; Willy Min Jou; Xavier Saelens; Walter Fiers
The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection.
Vaccine 2006;24(5):544-51.
2005: Dubravka Grdic; Lena Ekman; Karin Schön; Kristina Lindgren; Johan Mattsson; Karl-Eric Magnusson; Paola Ricciardi-Castagnoli; Nils Lycke
Splenic marginal zone dendritic cells mediate the cholera toxin adjuvant effect: dependence on the ADP-ribosyltransferase activity of the holotoxin.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5192-202.
2005: Nils Lycke
Targeted vaccine adjuvants based on modified cholera toxin.
Current molecular medicine 2005;5(6):591-7.
2005: Ali A Akhiani; Anneli Stensson; Karin Schön; Nils Lycke
IgA antibodies impair resistance against Helicobacter pylori infection: studies on immune evasion in IL-10-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):8144-53.
2005: Nils Lycke
From toxin to adjuvant: basic mechanisms for the control of mucosal IgA immunity and tolerance.
Immunology letters 2005;97(2):193-8.
2005: George Dindelegan; Mihai Oltean; Göran Kurlberg; Nils Lycke; Ola Nilsson; Michael Olausson
Accelerated acute rejection of the intestinal graft in CD28-deficient mice.
Transplantation proceedings 2005;37(1):82-6.
2004: Nils Lycke
ADP-ribosylating bacterial enzymes for the targeted control of mucosal tolerance and immunity.
Annals of the New York Academy of Sciences 2004;1029():193-208.
2004: Ali A Akhiani; Karin Schön; Nils Lycke
Vaccine-induced immunity against Helicobacter pylori infection is impaired in IL-18-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3348-56.
2004: Anna M Eriksson; Karin Schön; Nils Lycke
The cholera toxin-derived CTA1-DD vaccine adjuvant administered intranasally does not cause inflammation or accumulate in the nervous tissues.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3310-9.
2004: Ali A Akhiani; Karin Schön; Lennart E Franzén; Jacques Pappo; Nils Lycke
Helicobacter pylori-specific antibodies impair the development of gastritis, facilitate bacterial colonization, and counteract resistance against infection.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):5024-33.
2004: Nils Lycke
From toxin to adjuvant: the rational design of a vaccine adjuvant vector, CTA1-DD/ISCOM.
Cellular microbiology 2004;6(1):23-32.
2003: A Eriksson; Nils Lycke
The CTA1-DD vaccine adjuvant binds to human B cells and potentiates their T cell stimulating ability.
Vaccine 2003;22(2):185-93.
2003: Hans Lidén; George Dindelegan; Göran Kurlberg; Ola Nilsson; Anders Aneman; Nils Lycke; Michael Olausson
Graft mucosal blood flow is reduced prior to histologic evidence of rejection in mouse small bowel transplantation: a murine model.
Transplantation proceedings 2003;35(2):824-5.
2003: Martina Johansson; Nils Lycke
A unique population of extrathymically derived alpha beta TCR+CD4-CD8- T cells with regulatory functions dominates the mouse female genital tract.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1659-66.
2003: Martina Johansson; Nils Lycke
Immunology of the human genital tract.
Current opinion in infectious diseases 2003;16(1):43-9.
2003: George Dindelegan; Hans Liden; Göran Kurlberg; Mihai Oltean; Ola Nilsson; Anders Aneman; Nils Lycke; Michael Olausson
Laser-Doppler flowmetry is reliable for early diagnosis of small-bowel acute rejection in the mouse.
Microsurgery 2003;23(3):233-8.
2003: Eva Gärdby; Jens Wrammert; Karin Schön; Lena Ekman; Tomas Leanderson; Nils Lycke
Strong differential regulation of serum and mucosal IgA responses as revealed in CD28-deficient mice using cholera toxin adjuvant.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):55-63.
2002: Ali A Akhiani; Jacques Pappo; Zita Kabok; Karin Schön; Wei Gao; Lennart E Franzén; Nils Lycke
Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):6977-84.
2002: Anthony H-C Choi; Monica M McNeal; Jason A Flint; Mitali Basu; Nils Lycke; John Clements; Judy A Bean; Heather L Davis; Michael J McCluskie; John L VanCott; Richard L Ward
The level of protection against rotavirus shedding in mice following immunization with a chimeric VP6 protein is dependent on the route and the coadministered adjuvant.
Vaccine 2002;20(13-14):1733-40.
2001: Allan McI Mowat; Anne M Donachie; S Jägewall; Karin Schön; Björn Löwenadler; K Dalsgaard; P Kaastrup; Nils Lycke
CTA1-DD-immune stimulating complexes: a novel, rationally designed combined mucosal vaccine adjuvant effective with nanogram doses of antigen.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3398-405.
2001: L Erlandsson; Peter Akerblad; C Vingsbo-Lundberg; E Kallberg; Nils Lycke; Tomas Leanderson
Joining chain-expressing and -nonexpressing B cell populations in the mouse.
The Journal of experimental medicine 2001;194(5):557-70.
2001: Nils Lycke; R Coico
Measurement of immunoglobulin synthesis using the ELISPOT assay.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 7():Unit 7.14.
2001: Nils Lycke; Karin Schön
The B cell targeted adjuvant, CTA1-DD, exhibits potent mucosal immunoenhancing activity despite pre-existing anti-toxin immunity.
Vaccine 2001;19(17-19):2542-8.
2001: Martina Johansson; Nils Lycke
Immunological memory in B-cell-deficient mice conveys long-lasting protection against genital tract infection with Chlamydia trachomatis by rapid recruitment of T cells.
Immunology 2001;102(2):199-208.
2001: Nils Lycke
The B-cell targeted CTA1-DD vaccine adjuvant is highly effective at enhancing antibody as well as CTL responses.
Current opinion in molecular therapeutics 2001;3(1):37-44.
2001: Eva Gärdby; X J Chen; Nils Lycke
Impaired CD40-signalling in CD19-deficient mice selectively affects Th2-dependent isotype switching.
Scandinavian journal of immunology 2001;53(1):13-23.
2000: Eva Gärdby; Nils Lycke
CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches.
European journal of immunology 2000;30(7):1861-71.
2000: LC Agren; E Sverremark; Lena Ekman; Karin Schön; Björn Löwenadler; C Fernandez; Nils Lycke
The ADP-ribosylating CTA1-DD adjuvant enhances T cell-dependent and independent responses by direct action on B cells involving anti-apoptotic Bcl-2- and germinal center-promoting effects.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6276-86.
2000: Göran Kurlberg; Eva Haglind; Karin Schön; H Törnqvist; Nils Lycke
Blockade of the B7-CD28 pathway by CTLA4-Ig counteracts rejection and prolongs survival in small bowel transplantation.
Scandinavian journal of immunology 2000;51(3):224-30.
1999: Nils Lycke; L Erlandsson; Lena Ekman; Karin Schön; Tomas Leanderson
Lack of J chain inhibits the transport of gut IgA and abrogates the development of intestinal antitoxic protection.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):913-9.
1999: Dubravka Grdic; R Smith; Anne M Donachie; M Kjerrulf; Elisabeth Hultgren Hörnquist; Allan McI Mowat; Nils Lycke
The mucosal adjuvant effects of cholera toxin and immune-stimulating complexes differ in their requirement for IL-12, indicating different pathways of action.
European journal of immunology 1999;29(6):1774-84.
1999: Rosemary E Smith; Anne M Donachie; Dubravka Grdic; Nils Lycke; Allan McI Mowat
Immune-stimulating complexes induce an IL-12-dependent cascade of innate immune responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5536-46.
1999: XJ Chen; Nils Lycke; L Enerbäck
Surface and gene expression of immunoglobulin E receptors on mast cells and mast-cell numbers in interleukin-4-gene knockout mice.
Immunology 1999;96(4):544-50.
1999: LC Agren; Lena Ekman; Björn Löwenadler; J G Nedrud; Nils Lycke
Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2432-40.
1999: LC Agren; Martin Norin; Nils Lycke; Björn Löwenadler
Hydrophobicity engineering of cholera toxin A1 subunit in the strong adjuvant fusion protein CTA1-DD.
Protein engineering 1999;12(2):173-8.
1999: Allan McI Mowat; Rosemary E Smith; Anne M Donachie; Elizabeth Furrie; Dubravka Grdic; Nils Lycke
Oral vaccination with immune stimulating complexes.
Immunology letters 1999;65(1-2):133-40.
1998: L Erlandsson; K Andersson; Mikael Sigvardsson; Nils Lycke; Tomas Leanderson
Mice with an inactivated joining chain locus have perturbed IgM secretion.
European journal of immunology 1998;28(8):2355-65.
1998: Eva Gärdby; P Lane; Nils Lycke
Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):49-59.
1998: LC Agren; Björn Löwenadler; Nils Lycke
A novel concept in mucosal adjuvanticity: the CTA1-DD adjuvant is a B cell-targeted fusion protein that incorporates the enzymatically active cholera toxin A1 subunit.
Immunology and cell biology 1998;76(3):280-7.
1998: Thomas G Blanchard; Nils Lycke; Steven J Czinn; John G Nedrud
Recombinant cholera toxin B subunit is not an effective mucosal adjuvant for oral immunization of mice against Helicobacter felis.
Immunology 1998;94(1):22-7.
1998: M Kjerrulf; Dubravka Grdic; M Kopf; Nils Lycke
Induction of gut mucosal immune responses: importance of genetic background and Th1/Th2 cross-regulation.
Scandinavian journal of immunology 1998;47(5):401-7.
1998: Dubravka Grdic; Elisabeth Hultgren Hörnquist; M Kjerrulf; Nils Lycke
Lack of local suppression in orally tolerant CD8-deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):754-62.
1998: Nils Lycke
T cell and cytokine regulation of the IgA response.
Chemical immunology 1998;71():209-34.
1998: Eva Gärdby; D Kagrdic; M Kjerrulf; A Bromander; M Vajdy; Elisabeth Hultgren Hörnquist; Nils Lycke
The influence of costimulation and regulatory CD4+ T cells on intestinal IgA immune responses.
Developmental immunology 1998;6(1-2):53-60.
1997: Martina Johansson; M Ward; Nils Lycke
B-cell-deficient mice develop complete immune protection against genital tract infection with Chlamydia trachomatis.
Immunology 1997;92(4):422-8.
1997: Maria Johansson; Karin Schön; M Ward; Nils Lycke
Studies in knockout mice reveal that anti-chlamydial protection requires TH1 cells producing IFN-gamma: is this true for humans?
Scandinavian journal of immunology 1997;46(6):546-52.
1997: Marjan Mohammadi; John G Nedrud; Raymond W Redline; Nils Lycke; Steven J Czinn
Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load.
Gastroenterology 1997;113(6):1848-57.
1997: Nils Lycke
The mechanism of cholera toxin adjuvanticity.
Research in immunology 1997;148(8-9):504-20.
1997: M Kjerrulf; Dubravka Grdic; Lena Ekman; Karin Schön; M Vajdy; Nils Lycke
Interferon-gamma receptor-deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance.
Immunology 1997;92(1):60-8.
1997: M Kjerrulf; Björn Löwenadler; C Svanholm; Nils Lycke
Tandem repeats of T helper epitopes enhance immunogenicity of fusion proteins by promoting processing and presentation.
Molecular immunology 1997;34(8-9):599-608.
1997: LC Agren; Lena Ekman; Björn Löwenadler; Nils Lycke
Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3936-46.
1997: Martina Johansson; Karin Schön; M Ward; Nils Lycke
Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response.
Infection and immunity 1997;65(3):1032-44.
1997: Göran Kurlberg; Nils Lycke; Eva Haglind
Migration of host and donor T cells in small bowel transplantation.
Transplant international : official journal of the European Society for Organ Transplantation 1997;10(1):45-50.
1996: L Wassén; Karin Schön; J Holmgren; M Jertborn; Nils Lycke
Local intravaginal vaccination of the female genital tract.
Scandinavian journal of immunology 1996;44(4):408-14.
1996: Rolf Ehrhardt; G R Harriman; J K Inman; Nils Lycke; B Gray; W Strober
Differential activation requirements of isotype-switched B cells.
European journal of immunology 1996;26(8):1926-34.
1996: A K Bromander; Lena Ekman; Manfred Kopf; J G Nedrud; Nils Lycke
IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(11):4290-7.
1996: Ali A Akhiani; Nils Lycke; LA Nilsson; S Olling; O Ouchterlony
Lack of interferon-gamma receptor does not influence the outcome of infection in murine schistosomiasis mansoni.
Scandinavian journal of immunology 1996;43(3):257-62.
1996: Elisabeth Hultgren Hörnquist; Dubravka Grdic; T Mak; Nils Lycke
CD8-deficient mice exhibit augmented mucosal immune responses and intact adjuvant effects to cholera toxin.
Immunology 1996;87(2):220-9.
1995: M Vajdy; Nils Lycke
Mucosal memory B cells retain the ability to produce IgM antibodies 2 years after oral immunization.
Immunology 1995;86(3):336-42.
1995: C E Hörnquist; Lena Ekman; K D Grdic; Karin Schön; Nils Lycke
Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(6):2877-87.
1995: Nils Lycke
Analysis of the second messenger systems involved in the synergistic effect of cholera toxin and interleukin-4 on B cell isotype-switching.
Advances in experimental medicine and biology 1995;371A():15-20.
1995: M Vajdy; Marie H Kosco-Vilbois; Manfred Kopf; Gabriele Köhler; Nils Lycke
Impaired mucosal immune responses in interleukin 4-targeted mice.
The Journal of experimental medicine 1995;181(1):41-53.
1995: E Hornquist; Nils Lycke
Cholera toxin increases T lymphocyte responses to unrelated antigens.
Advances in experimental medicine and biology 1995;371B():1507-12.
1995: A K Bromander; M Kjerrulf; Jan Holmgren; Nils Lycke
Cholera toxin enhances antigen presentation.
Advances in experimental medicine and biology 1995;371B():1501-6.
1995: M Vajdy; Nils Lycke
Presence of antigen-specific long-term memory cells in systemic lymphoid tissues as well as locally in the gut lamina propria following oral immunization with cholera toxin adjuvant.
Advances in experimental medicine and biology 1995;371B():1495-500.
1994: Eva Sjögren-Jansson; Claes M Gustafsson; Stig Jeansson; U Karlsson; Nils Lycke
Production of large amounts of recombinant interleukins by cDNA transfected mouse myeloma cells cultured in dialysis tubing.
Journal of immunological methods 1994;168(1):131-6.
1994: Jan Holmgren; Cecil Czerkinsky; Nils Lycke; Ann-Mari Svennerholm
Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant.
The American journal of tropical medicine and hygiene 1994;50(5 Suppl):42-54.
1994: Björn Löwenadler; Nils Lycke
Fusion proteins with heterologous T helper epitopes. Recombinant E. coli heat-stable enterotoxin proteins.
International reviews of immunology 1994;11(2):103-11.
1993: M Vajdy; Nils Lycke
Stimulation of antigen-specific T- and B-cell memory in local as well as systemic lymphoid tissues following oral immunization with cholera toxin adjuvant.
Immunology 1993;80(2):197-203.
1993: Elisabeth Hultgren Hörnquist; Nils Lycke
Cholera toxin adjuvant greatly promotes antigen priming of T cells.
European journal of immunology 1993;23(9):2136-43.
1993: Jan Holmgren; Nils Lycke; Cecil Czerkinsky
Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems.
Vaccine 1993;11(12):1179-84.
1993: Nils Lycke
Cholera toxin promotes B cell isotype switching by two different mechanisms. cAMP induction augments germ-line Ig H-chain RNA transcripts whereas membrane ganglioside GM1-receptor binding enhances later events in differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):4810-21.
1993: E Hörnqvist; L Enerbäck; X J Chen; Nils Lycke
A novel large granular lymphocyte-like cell isolated from IL-2-supplemented murine intestinal lamina propria lymphocyte cultures with potent inhibitory action on lymphocyte proliferation.
Cellular immunology 1993;148(1):71-90.
1993: A K Bromander; M Kjerrulf; Jan Holmgren; Nils Lycke
Cholera toxin enhances alloantigen presentation by cultured intestinal epithelial cells.
Scandinavian journal of immunology 1993;37(4):452-8.
1992: Björn Löwenadler; Nils Lycke; C Svanholm; Ann-Mari Svennerholm; K Krook; Magnus Gidlund
T and B cell responses to chimeric proteins containing heterologous T helper epitopes inserted at different positions.
Molecular immunology 1992;29(10):1185-90.
1992: Nils Lycke; T Tsuji; Jan Holmgren
The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity.
European journal of immunology 1992;22(9):2277-81.
1992: M Vajdy; Nils Lycke
Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization.
Immunology 1992;75(3):488-92.
1992: Jan Holmgren; Cecil Czerkinsky; Nils Lycke; Ann-Mari Svennerholm
Mucosal immunity: implications for vaccine development.
Immunobiology 1992;184(2-3):157-79.
1992: G R Harriman; E Hörnqvist; Nils Lycke
Antigen-specific and polyclonal CD4+ lamina propria T-cell lines: phenotypic and functional characterization.
Immunology 1992;75(1):66-73.
1991: E Hörnqvist; T J Goldschmidt; Rikard Holmdahl; Nils Lycke
Host defense against cholera toxin is strongly CD4+ T cell dependent.
Infection and immunity 1991;59(10):3630-8.
1991: Nils Lycke; U Karlsson; A Sjölander; K E Magnusson
The adjuvant action of cholera toxin is associated with an increased intestinal permeability for luminal antigens.
Scandinavian journal of immunology 1991;33(6):691-8.
1991: A Bromander; Jan Holmgren; Nils Lycke
Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(9):2908-14.
1991: Nils Lycke; E Severinson; W Strober
Molecular effects of cholera toxin on isotype differentiation.
Immunologic research 1991;10(3-4):407-12.
1990: Nils Lycke; E Severinson; W Strober
Cholera toxin acts synergistically with IL-4 to promote IgG1 switch differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(10):3316-24.
1990: G R Harriman; Nils Lycke; L J Elwood; W Strober
T lymphocytes that express CD4 and the alpha beta-T cell receptor but lack Thy-1. Preferential localization in Peyer's patches.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(8):2406-14.
1989: Nils Lycke; W Strober
Cholera toxin promotes B cell isotype differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):3781-7.
1989: Cecil Czerkinsky; M W Russell; Nils Lycke; Marianne Lindblad; Jan Holmgren
Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues.
Infection and immunity 1989;57(4):1072-7.
1989: Nils Lycke; Jan Holmgren
Adoptive transfer of gut mucosal antitoxin memory by isolated B cells 1 year after oral immunization with cholera toxin.
Infection and immunity 1989;57(4):1137-41.
1989: Nils Lycke; Anders Kilander; LA Nilsson; Andrej Tarkowski; N Werner
Production of antibodies to gliadin in intestinal mucosa of patients with coeliac disease: a study at the single cell level.
Gut 1989;30(1):72-7.
1989: Nils Lycke; A K Bromander; Jan Holmgren
Role of local IgA antitoxin-producing cells for intestinal protection against cholera toxin challenge.
International archives of allergy and applied immunology 1989;88(3):273-9.
1989: Nils Lycke; A K Bromander; Lena Ekman; U Karlsson; Jan Holmgren
Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):20-7.
1988: Nils Lycke; Jan Holmgren
Mucosal immune response to cholera toxin--cellular basis of memory and adjuvant action.
Monographs in allergy 1988;24():274-81.
1986: Nils Lycke; Ann-Mari Svennerholm; Jan Holmgren
Strong biotype and serotype cross-protective antibacterial and antitoxic immunity in rabbits after cholera infection.
Microbial pathogenesis 1986;1(4):361-71.
1983: L Lindholm; Jan Holmgren; M Wikström; U Karlsson; K Andersson; Nils Lycke
Monoclonal antibodies to cholera toxin with special reference to cross-reactions with Escherichia coli heat-labile enterotoxin.
Infection and immunity 1983;40(2):570-6.