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David Lydall

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James M Dewar; David Lydall
Similarities and differences between "uncapped" telomeres and DNA double-strand breaks.
James M Dewar; David Lydall
Simple, non-radioactive measurement of single-stranded DNA at telomeric, sub-telomeric, and genomic loci in budding yeast.
Eva-Maria Holstein; David Lydall
Quantitative amplification of single-stranded DNA.

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All Publications

2012: James M Dewar; David Lydall
Similarities and differences between "uncapped" telomeres and DNA double-strand breaks.
Chromosoma 2012;121(2):117-30.
2012: James M Dewar; David Lydall
Simple, non-radioactive measurement of single-stranded DNA at telomeric, sub-telomeric, and genomic loci in budding yeast.
Methods in molecular biology (Clifton, N.J.) 2012;920():341-8.
2012: Eva-Maria Holstein; David Lydall
Quantitative amplification of single-stranded DNA.
Methods in molecular biology (Clifton, N.J.) 2012;920():323-39.
2012: A P Banks; C Lawless; David Lydall
A quantitative fitness analysis workflow.
Journal of visualized experiments : JoVE 2012;(66):.
2011: Hsin-Yu Chang; Conor Lawless; Stephen G Addinall; Sarah Oexle; Morgan Taschuk; Darren J Wilkinson; Anil Wipat; David Lydall
Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast.
G3 (Bethesda, Md.) 2011;1(3):197-208.
2011: Jochen Weile; Matthew Pocock; Simon J Cockell; Phillip Lord; James M Dewar; Eva-Maria Holstein; Darren Wilkinson; David Lydall; Jennifer Hallinan; Anil Wipat
Customizable views on semantically integrated networks for systems biology.
Bioinformatics (Oxford, England) 2011;27(9):1299-306.
2011: Stephen Gregory Addinall; Eva-Maria Holstein; Conor Lawless; Min Yu; Kaye Chapman; A Peter Banks; Hien-Ping Ngo; Laura Maringele; Morgan Taschuk; Alexander Young; Adam Ciesiolka; Allyson Lurena Lister; Anil Wipat; Darren James Wilkinson; David Lydall
Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects.
PLoS genetics 2011;7(4):e1001362.
2010: James M Dewar; David Lydall
Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.
The EMBO journal 2010;29(23):4020-34.
2010: Hien-Ping Ngo; David Lydall
Survival and growth of yeast without telomere capping by Cdc13 in the absence of Sgs1, Exo1, and Rad9.
PLoS genetics 2010;6(8):e1001072.
2010: James M Dewar; David Lydall
Telomere replication: Mre11 leads the way.
Molecular cell 2010;38(6):777-9.
2010: Conor Lawless; Darren J Wilkinson; Alexander Young; Stephen G Addinall; David Lydall
Colonyzer: automated quantification of micro-organism growth characteristics on solid agar.
BMC bioinformatics 2010;11():287.
2009: David Lydall
Taming the tiger by the tail: modulation of DNA damage responses by telomeres.
The EMBO journal 2009;28(15):2174-87.
2009: Catherine Lebel; Emanuel Rosonina; David C F Sealey; Fiona Pryde; David Lydall; Laura Maringele; Lea A Harrington
Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52.
Genetics 2009;182(3):671-84.
2008: Isabelle Morin; Hien-Ping Ngo; Amanda Greenall; Mikhajlo K Zubko; Nick Morrice; David Lydall
Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.
The EMBO journal 2008;27(18):2400-10.
2008: Federico Lazzaro; Vasileia Sapountzi; Magda Granata; Achille Pellicioli; Moreshwar Vaze; James E Haber; Paolo Plevani; David Lydall; Marco Muzi-Falconi
Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres.
The EMBO journal 2008;27(10):1502-12.
2008: Amanda Greenall; Guiyuan Lei; Daniel C Swan; Katherine James; Liming Wang; Heiko Peters; Anil Wipat; Darren J Wilkinson; David Lydall
A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection.
Genome biology 2008;9(10):R146.
2007: Avgi Tsolou; David Lydall
Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.
DNA repair 2007;6(11):1607-17.
2007: Carole J Proctor; David Lydall; Richard J Boys; C S Gillespie; Daryl P Shanley; Darren J Wilkinson; Thomas B L Kirkwood
Modelling the checkpoint response to telomere uncapping in budding yeast.
Journal of the Royal Society, Interface / the Royal Society 2007;4(12):73-90.
2006: Steven S Foster; Mikhajlo K Zubko; Sandrine Guillard; David Lydall
MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutants.
DNA repair 2006;5(7):840-51.
2006: Mikhajlo K Zubko; David Lydall
Linear chromosome maintenance in the absence of essential telomere-capping proteins.
Nature cell biology 2006;8(7):734-40.
2006: Michael Downey; Rebecca Houlsworth; Laura Maringele; Adrienne Rollie; Marc Brehme; Sarah Galicia; Sandrine Guillard; Melanie Partington; Mikhajlo K Zubko; Nevan J Krogan; Andrew Emili; Jack F Greenblatt; Lea Harrington; David Lydall; Daniel Durocher
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.
Cell 2006;124(6):1155-68.
2006: Mikhajlo K Zubko; Laura Maringele; Steven S Foster; David Lydall
Detecting repair intermediates in vivo: effects of DNA damage response genes on single-stranded DNA accumulation at uncapped telomeres in budding yeast.
Methods in enzymology 2006;409():285-300.
2006: Laura Maringele; David Lydall
Pulsed-field gel electrophoresis of budding yeast chromosomes.
Methods in molecular biology (Clifton, N.J.) 2006;313():65-73.
2005: David Lydall; Simon Whitehall
Chromatin and the DNA damage response.
DNA repair 2005;4(10):1195-207.
2005: Laura Maringele; David Lydall
The PAL-mechanism of chromosome maintenance: causes and consequences.
Cell cycle (Georgetown, Tex.) 2005;4(6):747-51.
2004: Laura Maringele; David Lydall
Telomerase- and recombination-independent immortalization of budding yeast.
Genes & development 2004;18(21):2663-75.
2004: Mikhajlo K Zubko; Sandrine Guillard; David Lydall
Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants.
Genetics 2004;168(1):103-15.
2004: Laura Maringele; David Lydall
EXO1 plays a role in generating type I and type II survivors in budding yeast.
Genetics 2004;166(4):1641-9.
2004: Xindan Jia; Ted Weinert; David Lydall
Mec1 and Rad53 inhibit formation of single-stranded DNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants.
Genetics 2004;166(2):753-64.
2004: Richard T Blankley; David Lydall
A domain of Rad9 specifically required for activation of Chk1 in budding yeast.
Journal of cell science 2004;117(Pt 4):601-8.
2003: David Lydall
Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways.
Journal of cell science 2003;116(Pt 20):4057-65.
2002: Laura Maringele; David Lydall
EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants.
Genes & development 2002;16(15):1919-33.
2001: C Booth; E Griffith; Gerard Brady; David Lydall
Quantitative amplification of single-stranded DNA (QAOS) demonstrates that cdc13-1 mutants generate ssDNA in a telomere to centromere direction.
Nucleic acids research 2001;29(21):4414-22.
1997: David Lydall; Ted Weinert
G2/M checkpoint genes of Saccharomyces cerevisiae: further evidence for roles in DNA replication and/or repair.
Molecular & general genetics : MGG 1997;256(6):638-51.
1997: David Lydall; Ted Weinert
Use of cdc13-1-induced DNA damage to study effects of checkpoint genes on DNA damage processing.
Methods in enzymology 1997;283():410-24.
1996: David Lydall; Y Nikolsky; D K Bishop; Ted Weinert
A meiotic recombination checkpoint controlled by mitotic checkpoint genes.
Nature 1996;383(6603):840-3.
1996: David Lydall; Ted Weinert
From DNA damage to cell cycle arrest and suicide: a budding yeast perspective.
Current opinion in genetics & development 1996;6(1):4-11.
1995: David Lydall; Ted Weinert
Yeast checkpoint genes in DNA damage processing: implications for repair and arrest.
Science (New York, N.Y.) 1995;270(5241):1488-91.
1993: Ted Weinert; David Lydall
Cell cycle checkpoints, genetic instability and cancer.
Seminars in cancer biology 1993;4(2):129-40.