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Frank Lyko

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Günter Raddatz; Markus Rampp; Wolf Reik; Matthias Schaefer; Marcelo Rosado Fantappié; Paloma M Guzzardo; Gregory J Hannon; Nelly Olova; Frank Lyko
Dnmt2-dependent methylomes lack defined DNA methylation patterns.
Cassandra Falckenhayn; Marcus Frohme; Günter Raddatz; Liliane Schoofs; Bart Boerjan; Frank Lyko
Characterization of genome methylation patterns in the desert locust Schistocerca gregaria.
Shobbir Hussain; Nobuaki R Kudo; Frank Lyko; Suraj Menon; Francesca Tuorto; Stephen Watt; Sandra Blanco; Claire Cox; Joana V Flores; Michaela Frye
The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation.

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All Publications

2013: Günter Raddatz; Markus Rampp; Wolf Reik; Matthias Schaefer; Marcelo Rosado Fantappié; Paloma M Guzzardo; Gregory J Hannon; Nelly Olova; Frank Lyko
Dnmt2-dependent methylomes lack defined DNA methylation patterns.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(21):8627-31.
2013: Cassandra Falckenhayn; Marcus Frohme; Günter Raddatz; Liliane Schoofs; Bart Boerjan; Frank Lyko
Characterization of genome methylation patterns in the desert locust Schistocerca gregaria.
The Journal of experimental biology 2013;216(Pt 8):1423-9.
2013: Shobbir Hussain; Nobuaki R Kudo; Frank Lyko; Suraj Menon; Francesca Tuorto; Stephen Watt; Sandra Blanco; Claire Cox; Joana V Flores; Michaela Frye
The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation.
Molecular and cellular biology 2013;33(8):1561-70.
2013: Zeljko Durdevic; Beth Gold; Katharina Hanna; Frank Lyko; Tim Pollex; Sara Cherry; Matthias Schaefer
Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2.
EMBO reports 2013;14(3):269-75.
2013: Meelad M Dawlaty; Kym F Faull; Qing Gao; Thuc Le; Zhe Li; Frank Lyko; Benjamin E Powell; Günter Raddatz; Mingjiang Xu; M Inmaculada Barrasa; Achim Breiling; Albert Cheng; Rudolf Jaenisch
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development.
Developmental cell 2013;24(3):310-23.
2013: Inês C Castro; Fatih Ceteci; Simone Hausmann; Sebastian Kress; Katharina Luetkenhaus; Frank Lyko; Achim Breiling; Thomas Rudel; Ulf R Rapp
MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma.
Molecular cancer research : MCR 2013;11(2):161-72.
2012: M Rius; Frank Lyko
Epigenetic cancer therapy: rationales, targets and drugs.
Oncogene 2012;31(39):4257-65.
2012: Francesca Tuorto; Tanja Musch; Matthias Schaefer; Georg Stoecklin; Michaela Frye; Mark Helm; Sarah Hofmann; Stefanie Kellner; Reinhard Liebers; Frank Lyko
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.
Nature structural & molecular biology 2012;19(9):900-5.
2012: Friederike Herbst; Ulrich Kloz; Frank Lyko; Ali Nowrouzi; Manfred Schmidt; Francesca Tuorto; Franciscus van der Hoeven; Christof von Kalle; Wei Wang; Oksana Zavidij; Claudia R Ball; Sebastian M Dieter; Sylvia Fessler; Hanno Glimm
Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(5):1014-21.
2012: Günter Raddatz; Sebastian Bender; Qing Gao; Rudolf Jaenisch; Frank Lyko
Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
PLoS genetics 2012;8(12):e1003146.
2012: Michael T Bocker; Frank Lyko; Tanja Musch; Günter Raddatz; Francesca Tuorto; Mingjiang Xu; Feng-Chun Yang; Achim Breiling
Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster.
Nature communications 2012;3():818.
2011: Michael T Bocker; Isabelle Hellwig; Achim Breiling; Volker Eckstein; Anthony D Ho; Frank Lyko
Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging.
Blood 2011;117(19):e182-9.
2011: Jose Medina-Franco; Fabian López-Vallejo; Dirk Kuck; Frank Lyko
Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach.
Molecular diversity 2011;15(2):293-304.
2011: Frank Lyko; Ryszard Maleszka
Insects as innovative models for functional studies of DNA methylation.
Trends in genetics : TIG 2011;27(4):127-31.
2011: Sabine Hagemann; Oliver Heil; Frank Lyko; Bodo Brueckner
Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines.
PloS one 2011;6(3):e17388.
2010: Matthias Schaefer; Frank Lyko
Lack of evidence for DNA methylation of Invader4 retroelements in Drosophila and implications for Dnmt2-mediated epigenetic regulation.
Nature genetics 2010;42(11):920-1; author reply 921.
2010: Dirk Kuck; Thomas Caulfield; Frank Lyko; Jose L Medina-Franco
Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells.
Molecular cancer therapeutics 2010;9(11):3015-23.
2010: B Weber; S Kimhi; G Howard; A Eden; Frank Lyko
Demethylation of a LINE-1 antisense promoter in the cMet locus impairs Met signalling through induction of illegitimate transcription.
Oncogene 2010;29(43):5775-84.
2010: Matthias Schaefer; Tim Pollex; Katharina Hanna; Francesca Tuorto; Madeleine Meusburger; Mark Helm; Frank Lyko
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.
Genes & development 2010;24(15):1590-5.
2010: Maria Rius; Daniela Keller; Manuela Brom; Johanna Hummel-Eisenbeiss; Frank Lyko; Dietrich Keppler
Vectorial transport of nucleoside analogs from the apical to the basolateral membrane in double-transfected cells expressing the human concentrative nucleoside transporter hCNT3 and the export pump ABCC4.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(7):1054-63.
2010: Elke Grönniger; Barbara Weber; Oliver Heil; Nils Peters; Franz Stäb; Horst Wenck; Bernhard Korn; Marc Winnefeld; Frank Lyko
Aging and chronic sun exposure cause distinct epigenetic changes in human skin.
PLoS genetics 2010;6(5):e1000971.
2010: Bodo Brueckner; Maria Rius; Maria Rivera Markelova; Iduna Fichtner; Petter-Arnt Hals; Marit Liland Sandvold; Frank Lyko
Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy.
Molecular cancer therapeutics 2010;9(5):1256-64.
2010: Yuri Motorin; Frank Lyko; Mark Helm
5-methylcytosine in RNA: detection, enzymatic formation and biological functions.
Nucleic acids research 2010;38(5):1415-30.
2010: Matthias Schaefer; Frank Lyko
Solving the Dnmt2 enigma.
Chromosoma 2010;119(1):35-40.
2010: Dirk Kuck; Narender Singh; Frank Lyko; Jose L Medina-Franco
Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation.
Bioorganic & medicinal chemistry 2010;18(2):822-9.
2010: Frank Lyko; Sylvain Foret; Robert Kucharski; Stephan Wolf; Cassandra Falckenhayn; Ryszard Maleszka
The honey bee epigenomes: differential methylation of brain DNA in queens and workers.
PLoS biology 2010;8(11):e1000506.
2010: Tanja Musch; Yuva Oz; Frank Lyko; Achim Breiling
Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factors.
PloS one 2010;5(5):e10726.
2009: Matthias Schaefer; Sabine Hagemann; Katharina Hanna; Frank Lyko
Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines.
Cancer research 2009;69(20):8127-32.
2009: Narender Singh; Alfonso Dueñas-González; Frank Lyko; Jose L Medina-Franco
Molecular modeling and molecular dynamics studies of hydralazine with human DNA methyltransferase 1.
ChemMedChem 2009;4(5):792-9.
2009: Matthias Schaefer; Tim Pollex; Katharina Hanna; Frank Lyko
RNA cytosine methylation analysis by bisulfite sequencing.
Nucleic acids research 2009;37(2):e12.
2009: Maria Rius; Carlo Stresemann; Daniela Keller; Manuela Brom; Esther Schirrmacher; Dietrich Keppler; Frank Lyko
Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation.
Molecular cancer therapeutics 2009;8(1):225-31.
2008: Carlo Stresemann; Imke Bokelmann; Ulrich Mahlknecht; Frank Lyko
Azacytidine causes complex DNA methylation responses in myeloid leukemia.
Molecular cancer therapeutics 2008;7(9):2998-3005.
2008: Carlo Stresemann; Frank Lyko
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine.
International journal of cancer. Journal international du cancer 2008;123(1):8-13.
2008: Sabrina Castellano; Dirk Kuck; Marina Sala; Ettore Novellino; Frank Lyko; Gianluca Sbardella
Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1.
Journal of medicinal chemistry 2008;51(7):2321-5.
2008: Frank Lyko
Epigenetics and New Therapies in Cancer--An ESO-CNIO Conference. 29-30 November 2007, Madrid, Spain.
IDrugs : the investigational drugs journal 2008;11(2):79-81.
2008: Matthias Schaefer; Julia P Steringer; Frank Lyko
The Drosophila cytosine-5 methyltransferase Dnmt2 is associated with the nuclear matrix and can access DNA during mitosis.
PloS one 2008;3(1):e1414.
2008: Martin Hengesbach; Madeleine Meusburger; Frank Lyko; Mark Helm
Use of DNAzymes for site-specific analysis of ribonucleotide modifications.
RNA (New York, N.Y.) 2008;14(1):180-7.
2007: Barbara Weber; Carlo Stresemann; Bodo Brueckner; Frank Lyko
Methylation of human microRNA genes in normal and neoplastic cells.
Cell cycle (Georgetown, Tex.) 2007;6(9):1001-5.
2007: Matthias Schaefer; Madeleine Meusburger; Frank Lyko
Non-mammalian models for epigenetic analyses in cancer.
Human molecular genetics 2007;16 Spec No 1():R1-6.
2007: Matthias Schaefer; Frank Lyko
DNA methylation with a sting: an active DNA methylation system in the honeybee.
BioEssays : news and reviews in molecular, cellular and developmental biology 2007;29(3):208-11.
2007: Bodo Brueckner; Carlo Stresemann; Ruprecht Kuner; Cora Mund; Tanja Musch; Michael Meister; Holger Sültmann; Frank Lyko
The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function.
Cancer research 2007;67(4):1419-23.
2007: Guillermo Barreto; Andrea Schäfer; Joachim Marhold; Dirk Stach; Suresh K Swaminathan; Vikas Handa; Gabi Döderlein; Nicole Maltry; Wei Wu; Frank Lyko; Christof Niehrs
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.
Nature 2007;445(7128):671-5.
2007: Bodo Brueckner; Dirk Kuck; Frank Lyko
DNA methyltransferase inhibitors for cancer therapy.
Cancer journal (Sudbury, Mass.) 2007;13(1):17-22.
2006: Mohsen Karimi; Sofia Johansson; Dirk Stach; Martin Corcoran; Dan Grandér; Martin Schalling; Georgy Bakalkin; Frank Lyko; Catharina Larsson; Tomas J Ekström
LUMA (LUminometric Methylation Assay)--a high throughput method to the analysis of genomic DNA methylation.
Experimental cell research 2006;312(11):1989-95.
2006: Stefan Hiendleder; Michaela Wirtz; Cora Mund; Martina Klempt; Horst-Dieter Reichenbach; Miodrag Stojkovic; Myriam Weppert; Hendrik Wenigerkind; Martin W Elmlinger; Frank Lyko; Oliver J Schmitz; Eckhard Wolf
Tissue-specific effects of in vitro fertilization procedures on genomic cytosine methylation levels in overgrown and normal sized bovine fetuses.
Biology of reproduction 2006;75(1):17-23.
2006: Albert Jeltsch; Wolfgang Nellen; Frank Lyko
Two substrates are better than one: dual specificities for Dnmt2 methyltransferases.
Trends in biochemical sciences 2006;31(6):306-8.
2006: Daniel Mertens; Stephan Wolf; Cordula Tschuch; Cora Mund; Dirk Kienle; Sibylle Ohl; Petra Schroeter; Frank Lyko; Hartmut Döhner; Stephan Stilgenbauer; Peter Lichter
Allelic silencing at the tumor-suppressor locus 13q14.3 suggests an epigenetic tumor-suppressor mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7741-6.
2006: Esther Schirrmacher; Carmen Beck; Bodo Brueckner; Frank Schmitges; Pawel Siedlecki; Peter Bartenstein; Frank Lyko; Ralf Schirrmacher
Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases.
Bioconjugate chemistry 2006;17(2):261-6.
2006: Carlo Stresemann; Bodo Brueckner; Tanja Musch; Helga Stopper; Frank Lyko
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.
Cancer research 2006;66(5):2794-800.
2006: Pawel Siedlecki; Regine Garcia Boy; Tanja Musch; Bodo Brueckner; Sándor Suhai; Frank Lyko; Piotr Zielenkiewicz
Discovery of two novel, small-molecule inhibitors of DNA methylation.
Journal of medicinal chemistry 2006;49(2):678-83.
2006: Cora Mund; Bodo Brueckner; Frank Lyko
Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications.
Epigenetics : official journal of the DNA Methylation Society 2006;1(1):7-13.
2006: Frank Lyko; Christian Beisel; Joachim Marhold; Renato Paro
Epigenetic regulation in Drosophila.
Current topics in microbiology and immunology 2006;310():23-44.
2005: Frank Lyko; Robert Brown
DNA methyltransferase inhibitors and the development of epigenetic cancer therapies.
Journal of the National Cancer Institute 2005;97(20):1498-506.
2005: Cora Mund; Björn Hackanson; Carlo Stresemann; Michael Lübbert; Frank Lyko
Characterization of DNA demethylation effects induced by 5-Aza-2'-deoxycytidine in patients with myelodysplastic syndrome.
Cancer research 2005;65(16):7086-90.
2005: Bodo Brueckner; Regine Garcia Boy; Pawel Siedlecki; Tanja Musch; Hans-Christian Kliem; Piotr Zielenkiewicz; Sándor Suhai; Manfred Wiessler; Frank Lyko
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.
Cancer research 2005;65(14):6305-11.
2005: Markus Kuhlmann; Branimira E Borisova; Markus Kaller; Pontus Larsson; Dirk Stach; Jianbo Na; Ludwig Eichinger; Frank Lyko; Victor Ambros; Fredrik Söderbom; Christian Hammann; Wolfgang Nellen
Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi.
Nucleic acids research 2005;33(19):6405-17.
2005: Cora Mund; Verena Beier; Peter Bewerunge; Michael Dahms; Frank Lyko; Jörg D Hoheisel
Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p16INK4A promoter in colon carcinoma cell lines.
Nucleic acids research 2005;33(8):e73.
2005: Frank Lyko
Novel methods for analysis of genomic DNA methylation.
Analytical and bioanalytical chemistry 2005;381(1):67-8.
2004: Joachim Marhold; Katja Kramer; Elisabeth Kremmer; Frank Lyko
The Drosophila MBD2/3 protein mediates interactions between the MI-2 chromatin complex and CpT/A-methylated DNA.
Development (Cambridge, England) 2004;131(24):6033-9.
2004: Bodo Brueckner; Frank Lyko
DNA methyltransferase inhibitors: old and new drugs for an epigenetic cancer therapy.
Trends in pharmacological sciences 2004;25(11):551-4.
2004: Stefan Hiendleder; Cora Mund; Horst-Dieter Reichenbach; Hendrik Wenigerkind; Gottfried Brem; Valeri Zakhartchenko; Frank Lyko; Eckhard Wolf
Tissue-specific elevated genomic cytosine methylation levels are associated with an overgrowth phenotype of bovine fetuses derived by in vitro techniques.
Biology of reproduction 2004;71(1):217-23.
2004: Frank Lyko; Dirk Stach; Axel Brenner; Stephan Stilgenbauer; Hartmut Döhner; Michaela Wirtz; Manfred Wiessler; Oliver J Schmitz
Quantitative analysis of DNA methylation in chronic lymphocytic leukemia patients.
Electrophoresis 2004;25(10-11):1530-5.
2004: Joachim Marhold; N Rothe; Andrea Pauli; Cora Mund; K Kuehle; Bodo Brueckner; Frank Lyko
Conservation of DNA methylation in dipteran insects.
Insect molecular biology 2004;13(2):117-23.
2004: Cora Mund; Tanja Musch; Martin Strödicke; Birte Assmann; En Li; Frank Lyko
Comparative analysis of DNA methylation patterns in transgenic Drosophila overexpressing mouse DNA methyltransferases.
The Biochemical journal 2004;378(Pt 3):763-8.
2003: Natascha Kunert; Joachim Marhold; Jonas Stanke; Dirk Stach; Frank Lyko
A Dnmt2-like protein mediates DNA methylation in Drosophila.
Development (Cambridge, England) 2003;130(21):5083-90.
2003: Frank Weissmann; Frank Lyko
Cooperative interactions between epigenetic modifications and their function in the regulation of chromosome architecture.
BioEssays : news and reviews in molecular, cellular and developmental biology 2003;25(8):792-7.
2003: Sylvia Erhardt; Frank Lyko; Justin F-X Ainscough; M Azim Surani; Renato Paro
Polycomb-group proteins are involved in silencing processes caused by a transgenic element from the murine imprinted H19/Igf2 region in Drosophila.
Development genes and evolution 2003;213(7):336-44.
2003: Pawel Siedlecki; Regine Garcia Boy; Slobodan Comagic; Ralf Schirrmacher; Manfred Wiessler; Piotr Zielenkiewicz; Sándor Suhai; Frank Lyko
Establishment and functional validation of a structural homology model for human DNA methyltransferase 1.
Biochemical and biophysical research communications 2003;306(2):558-63.
2003: Frank Weissmann; Inhua Muyrers-Chen; Tanja Musch; Dirk Stach; Manfred Wiessler; Renato Paro; Frank Lyko
DNA hypermethylation in Drosophila melanogaster causes irregular chromosome condensation and dysregulation of epigenetic histone modifications.
Molecular and cellular biology 2003;23(7):2577-86.
2003: Susanne Lankenau; Thorsten Barnickel; Joachim Marhold; Frank Lyko; Bernard M Mechler; Dirk-Henner Lankenau
Knockout targeting of the Drosophila nap1 gene and examination of DNA repair tracts in the recombination products.
Genetics 2003;163(2):611-23.
2003: Dirk Stach; Oliver J Schmitz; Stephan Stilgenbauer; Axel Benner; Hartmut Döhner; Manfred Wiessler; Frank Lyko
Capillary electrophoretic analysis of genomic DNA methylation levels.
Nucleic acids research 2003;31(2):E2.
2002: Joachim Marhold; Marcin Zbylut; Dirk-Henner Lankenau; Mingfa Li; Daniel Gerlich; Esteban Ballestar; Bernard M Mechler; Frank Lyko
Stage-specific chromosomal association of Drosophila dMBD2/3 during genome activation.
Chromosoma 2002;111(1):13-21.
1999: Frank Lyko; Renato Paro
Chromosomal elements conferring epigenetic inheritance.
BioEssays : news and reviews in molecular, cellular and developmental biology 1999;21(10):824-32.
1998: Frank Lyko; Karin Buiting; B Horsthemke; Renato Paro
Identification of a silencing element in the human 15q11-q13 imprinting center by using transgenic Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1698-702.
1998: James D Brenton; Justin F-X Ainscough; Frank Lyko; Renato Paro; M Azim Surani
Imprinting and gene silencing in mice and Drosophila.
Novartis Foundation symposium 1998;214():233-44; discussion 244-50.
1997: Frank Lyko; James D Brenton; M Azim Surani; Renato Paro
An imprinting element from the mouse H19 locus functions as a silencer in Drosophila.
Nature genetics 1997;16(2):171-3.