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Dena Lyras

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Publications

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Radhika Bantwal; Dena Lyras; Corrine J Porter; Noelene S Quinsey; Vicki Adams; Trudi L Bannam; Julian I Rood
The peptidoglycan hydrolase TcpG is required for efficient conjugative transfer of pCW3 in Clostridium perfringens.
Glen P Carter; Gillian R Douce; Bruno Dupuy; Revathi Govind; Pauline M Howarth; Grant A Jenkin; Despina Kotsanas; Ana Antunes; Anthony M Buckley; Kate E Mackin; Julian I Rood; Janice Spencer; Dena Lyras
The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile.
Seth T Walk; Vincent Bensan Young; Glen P Carter; Sylvia Grossman; Yibai Hao; Ruchika Jain; Dena Lyras; Duane W Newton; J Glenn Songer; Tennille Thelen; Itishree Trivedi; David M Aronoff
Non-toxigenic Clostridium sordellii: clinical and microbiological features of a case of cholangitis-associated bacteremia.

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All Publications

2012: Radhika Bantwal; Dena Lyras; Corrine J Porter; Noelene S Quinsey; Vicki Adams; Trudi L Bannam; Julian I Rood
The peptidoglycan hydrolase TcpG is required for efficient conjugative transfer of pCW3 in Clostridium perfringens.
Plasmid 2012;67(2):139-47.
2011: Glen P Carter; Gillian R Douce; Bruno Dupuy; Revathi Govind; Pauline M Howarth; Grant A Jenkin; Despina Kotsanas; Ana Antunes; Anthony M Buckley; Kate E Mackin; Julian I Rood; Janice Spencer; Dena Lyras
The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile.
PLoS pathogens 2011;7(10):e1002317.
2011: Seth T Walk; Vincent Bensan Young; Glen P Carter; Sylvia Grossman; Yibai Hao; Ruchika Jain; Dena Lyras; Duane W Newton; J Glenn Songer; Tennille Thelen; Itishree Trivedi; David M Aronoff
Non-toxigenic Clostridium sordellii: clinical and microbiological features of a case of cholangitis-associated bacteremia.
Anaerobe 2011;17(5):252-6.
2011: Michael Richards; James Knox; Briony Elliott; Kate Mackin; Dena Lyras; Lynette J Waring; Thomas V Riley
Severe infection with Clostridium difficile PCR ribotype 027 acquired in Melbourne, Australia.
The Medical journal of Australia 2011;194(7):369-71.
2011: Glen P Carter; Milena M Awad; Yibai Hao; Tennille Thelen; Ingrid L Bergin; Pauline M Howarth; Torsten Seemann; Julian I Rood; David M Aronoff; Dena Lyras
TcsL is an essential virulence factor in Clostridium sordellii ATCC 9714.
Infection and immunity 2011;79(3):1025-32.
2011: Glen P Carter; Milena M Awad; Michelle L Kelly; Julian I Rood; Dena Lyras
TcdB or not TcdB: a tale of two Clostridium difficile toxins.
Future microbiology 2011;6(2):121-3.
2011: Anjana Chakravorty; Jackie K Cheung; Jocelyn M Choo; Thomas J Hiscox; Dena Lyras; Milena M Awad; Glen P Carter; Julian I Rood
The cysteine protease α-clostripain is not essential for the pathogenesis of Clostridium perfringens-mediated myonecrosis.
PloS one 2011;6(7):e22762.
2010: Despina Kotsanas; Jolene A Carson; Milena M Awad; Dena Lyras; Julian I Rood; Grant A Jenkin; RL Stuart; Tony M Korman
Novel use of tryptose sulfite cycloserine egg yolk agar for isolation of Clostridium perfringens during an outbreak of necrotizing enterocolitis in a neonatal unit.
Journal of clinical microbiology 2010;48(11):4263-5.
2010: Glen P Carter; Dena Lyras; Rachael Poon; Pauline M Howarth; Julian I Rood
Methods for gene cloning and targeted mutagenesis.
Methods in molecular biology (Clifton, N.J.) 2010;646():183-201.
2009: Dena Lyras; Vicki Adams; Susan A Ballard; Wee L Teng; Pauline M Howarth; PK Crellin; Trudi L Bannam; J Glenn Songer; Julian I Rood
tISCpe8, an IS1595-family lincomycin resistance element located on a conjugative plasmid in Clostridium perfringens.
Journal of bacteriology 2009;191(20):6345-51.
2009: Martina Chiarezza; Dena Lyras; Sacha J Pidot; Marietta Flores-Díaz; Milena M Awad; Catherine Kennedy; Leanne M Cordner; Tongted Phumoonna; Rachael Poon; Meredith L Hughes; John J Emmins; Alberto Alape-Girón; Julian I Rood
The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence.
Infection and immunity 2009;77(10):4421-8.
2009: Catherine Kennedy; Danielle J Smith; Dena Lyras; Anjana Chakravorty; Julian I Rood
Programmed cellular necrosis mediated by the pore-forming alpha-toxin from Clostridium septicum.
PLoS pathogens 2009;5(7):e1000516.
2009: Dena Lyras; Jennifer R O'Connor; Pauline M Howarth; Susan P Sambol; Glen P Carter; Tongted Phumoonna; Rachael Poon; Vicki Adams; Gayatri Vedantam; Stuart Johnson; Dale N Gerding; Julian I Rood
Toxin B is essential for virulence of Clostridium difficile.
Nature 2009;458(7242):1176-9.
2009: Catherine Kennedy; Dena Lyras; Jackie K Cheung; Thomas J Hiscox; John J Emmins; Julian I Rood
Cross-complementation of Clostridium perfringens PLC and Clostridium septicum alpha-toxin mutants reveals PLC is sufficient to mediate gas gangrene.
Microbes and infection / Institut Pasteur 2009;11(3):413-8.
2009: Catherine Kennedy; Dena Lyras; Leanne M Cordner; Jody Melton-Witt; John J Emmins; Rodney K Tweten; Julian I Rood
Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis.
Infection and immunity 2009;77(3):943-51.
2008: Michael J Hickey; Rain Y Q Kwan; Milena M Awad; Catherine Kennedy; Lauren F Young; Pam Hall; Leanne M Cordner; Dena Lyras; John J Emmins; Julian I Rood
Molecular and cellular basis of microvascular perfusion deficits induced by Clostridium perfringens and Clostridium septicum.
PLoS pathogens 2008;4(4):e1000045.
2008: Sharon Tennant; Elizabeth L Hartland; Tongted Phumoonna; Dena Lyras; Julian I Rood; Roy M Robins-Browne; Ian R van Driel
Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens.
Infection and immunity 2008;76(2):639-45.
2007: Glen P Carter; Dena Lyras; David L Allen; Kate E Mackin; Pauline M Howarth; Jennifer R O'Connor; Julian I Rood
Binary toxin production in Clostridium difficile is regulated by CdtR, a LytTR family response regulator.
Journal of bacteriology 2007;189(20):7290-301.
2006: Jennifer R O'Connor; Dena Lyras; Kylie A Farrow; Vicki Adams; David R Powell; Jason Hinds; Jackie K Cheung; Julian I Rood
Construction and analysis of chromosomal Clostridium difficile mutants.
Molecular microbiology 2006;61(5):1335-51.
2006: Trudi L Bannam; Wee Lin Teng; Dieter Bulach; Dena Lyras; Julian I Rood
Functional identification of conjugation and replication regions of the tetracycline resistance plasmid pCW3 from Clostridium perfringens.
Journal of bacteriology 2006;188(13):4942-51.
2006: Vicki Adams; isabelle lucet; Fleur E Tynan; Martina Chiarezza; Pauline M Howarth; Jonathan Kim; Jamie Rossjohn; Dena Lyras; Julian I Rood
Two distinct regions of the large serine recombinase TnpX are required for DNA binding and biological function.
Molecular microbiology 2006;60(3):591-601.
2005: Catherine Kennedy; Efrosinia O Krejany; Lauren F Young; Jennifer R O'Connor; Milena M Awad; Richard L Boyd; John J Emmins; Dena Lyras; Julian I Rood
The alpha-toxin of Clostridium septicum is essential for virulence.
Molecular microbiology 2005;57(5):1357-66.
2005: isabelle lucet; Fleur E Tynan; Vicki Adams; Jamie Rossjohn; Dena Lyras; Julian I Rood
Identification of the structural and functional domains of the large serine recombinase TnpX from Clostridium perfringens.
The Journal of biological chemistry 2005;280(4):2503-11.
2004: Vicki Adams; isabelle lucet; Dena Lyras; Julian I Rood
DNA binding properties of TnpX indicate that different synapses are formed in the excision and integration of the Tn4451 family.
Molecular microbiology 2004;53(4):1195-207.
2004: Dena Lyras; Vicki Adams; isabelle lucet; Julian I Rood
The large resolvase TnpX is the only transposon-encoded protein required for transposition of the Tn4451/3 family of integrative mobilizable elements.
Molecular microbiology 2004;51(6):1787-800.
2003: Tiffany R Shultz; John W Tapsall; Peter White; Catherine S Ryan; Dena Lyras; Julian I Rood; Enzo Binotto; Christopher J L Richardson
Chloramphenicol-resistant Neisseria meningitidis containing catP isolated in Australia.
The Journal of antimicrobial chemotherapy 2003;52(5):856-9.
2002: Vicki Adams; Dena Lyras; Kylie A Farrow; Julian I Rood
The clostridial mobilisable transposons.
Cellular and molecular life sciences : CMLS 2002;59(12):2033-43.
2002: Nagraj Mani; Dena Lyras; Lisa Barroso; Pauline M Howarth; Tracy D Wilkins; Julian I Rood; Abraham L Sonenshein; Bruno Dupuy
Environmental response and autoregulation of Clostridium difficile TxeR, a sigma factor for toxin gene expression.
Journal of bacteriology 2002;184(21):5971-8.
2002: Kylie A Farrow; Dena Lyras; Galina Polekhina; Katerina Koutsis; Michael W Parker; Julian I Rood
Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens.
Antimicrobial agents and chemotherapy 2002;46(5):1253-61.
2001: Priscilla A Johanesen; Dena Lyras; Trudi L Bannam; Julian I Rood
Transcriptional analysis of the tet(P) operon from Clostridium perfringens.
Journal of bacteriology 2001;183(24):7110-9.
2001: Priscilla A Johanesen; Dena Lyras; Julian I Rood
Induction of pCW3-encoded tetracycline resistance in Clostridium perfringens involves a host-encoded factor.
Plasmid 2001;46(3):229-32.
2001: Kylie A Farrow; Dena Lyras; Julian I Rood
Genomic analysis of the erythromycin resistance element Tn5398 from Clostridium difficile.
Microbiology (Reading, England) 2001;147(Pt 10):2717-28.
2001: Adam Roberts; Priscilla A Johanesen; Dena Lyras; Peter Mullany; Julian I Rood
Comparison of Tn5397 from Clostridium difficile, Tn916 from Enterococcus faecalis and the CW459tet(M) element from Clostridium perfringens shows that they have similar conjugation regions but different insertion and excision modules.
Microbiology (Reading, England) 2001;147(Pt 5):1243-51.
2000: Dena Lyras; Julian I Rood
Transposition of Tn4451 and Tn4453 involves a circular intermediate that forms a promoter for the large resolvase, TnpX.
Molecular microbiology 2000;38(3):588-601.
2000: H Wang; Adam Roberts; Dena Lyras; Julian I Rood; M Wilks; Peter Mullany
Characterization of the ends and target sites of the novel conjugative transposon Tn5397 from Clostridium difficile: excision and circularization is mediated by the large resolvase, TndX.
Journal of bacteriology 2000;182(13):3775-83.
2000: Kylie A Farrow; Dena Lyras; Julian I Rood
The macrolide-lincosamide-streptogramin B resistance determinant from Clostridium difficile 630 contains two erm(B) genes.
Antimicrobial agents and chemotherapy 2000;44(2):411-3.
1999: S Johnson; Matthew H Samore; Kylie A Farrow; George Killgore; Fred C Tenover; Dena Lyras; Julian I Rood; Paola C DeGirolami; Aldona L Baltch; ME Rafferty; S M Pear; Dale N Gerding
Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitals.
The New England journal of medicine 1999;341(22):1645-51.
1998: Dena Lyras; C Storie; A S Huggins; PK Crellin; Trudi L Bannam; Julian I Rood
Chloramphenicol resistance in Clostridium difficile is encoded on Tn4453 transposons that are closely related to Tn4451 from Clostridium perfringens.
Antimicrobial agents and chemotherapy 1998;42(7):1563-7.
1998: Dena Lyras; Julian I Rood
Conjugative transfer of RP4-oriT shuttle vectors from Escherichia coli to Clostridium perfringens.
Plasmid 1998;39(2):160-4.
1996: Dena Lyras; Julian I Rood
Genetic organization and distribution of tetracycline resistance determinants in Clostridium perfringens.
Antimicrobial agents and chemotherapy 1996;40(11):2500-4.
1994: Joan Sloan; Laura M McMurry; Dena Lyras; Stuart B Levy; Julian I Rood
The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants.
Molecular microbiology 1994;11(2):403-15.