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Shou-wu Ma

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Ravil R Petrov; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Josephine Lai; Yeon Sun Lee; Lu Liu; Shou-wu Ma; Peg Davis; Victor J Hruby
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Katherine E Hanlon; Dave S Herman; Richard S Agnes; Tally M Largent-Milnes; Isuru R Kumarasinghe; Shou-wu Ma; Wenhong Guo; Yeon-Sun Lee; Michael H Ossipov; Victor J Hruby; Josephine Lai; Frank Porreca; Todd W Vanderah
Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain.
Takashi Yamamoto; Padma Nair; Tally M Largent-Milnes; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.

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All Publications

2013: Ravil R Petrov; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Josephine Lai; Yeon Sun Lee; Lu Liu; Shou-wu Ma; Peg Davis; Victor J Hruby
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Bioorganic & medicinal chemistry letters 2013;23(11):3434-7.
2011: Katherine E Hanlon; Dave S Herman; Richard S Agnes; Tally M Largent-Milnes; Isuru R Kumarasinghe; Shou-wu Ma; Wenhong Guo; Yeon-Sun Lee; Michael H Ossipov; Victor J Hruby; Josephine Lai; Frank Porreca; Todd W Vanderah
Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain.
Brain research 2011;1395():1-11.
2011: Takashi Yamamoto; Padma Nair; Tally M Largent-Milnes; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Journal of medicinal chemistry 2011;54(7):2029-38.
2011: Yeon Sun Lee; Shou-wu Ma; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Scott M Cowell; Peg Davis; Katherine E Hanlon; Vinod Kulkarani; Josephine Lai; Victor J Hruby
Development of potent μ and δ opioid agonists with high lipophilicity.
Journal of medicinal chemistry 2011;54(1):382-6.
2010: Yeon Sun Lee; Steve Fernandes; Vinod Kulkarani; Alexander V Mayorov; Peg Davis; Shou-wu Ma; Kathy Brown; Robert J Gillies; Josephine Lai; Frank Porreca; Victor J Hruby
Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.
Bioorganic & medicinal chemistry letters 2010;20(14):4080-4.
2009: Takashi Yamamoto; Padma Nair; Shou-wu Ma; Peg Davis; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Bioorganic & medicinal chemistry 2009;17(20):7337-43.
2009: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Josef Vagner; Vinod Kulkarni; Peg Davis; Shou-wu Ma; Edita Navratilova; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2009;52(16):5164-75.
2009: Padma Nair; Takashi Yamamoto; Vinod Kulkarni; Sharif Moye; Edita Navratilova; Peg Davis; Tally Largent; Shou-wu Ma; Henry I Yamamura; Todd W Vanderah; Josephine Lai; Frank Porreca; Victor J Hruby
Novel bifunctional peptides as opioid agonists and NK-1 antagonists.
Advances in experimental medicine and biology 2009;611():537-8.
2009: YeonSun Lee; Ravil Petrov; Vinod Kulkarni; Byoung J Min; Shou-wu Ma; Peg Davis; Janice Oyarzo; Todd W Vanderah; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety.
Advances in experimental medicine and biology 2009;611():517-8.
2009: Vinod V Kulkarni; Yeon Sun Lee; Christine Salibay; Peg Davis; Shou-wu Ma; Frank Porreca; Victor J Hruby
Novel analogues of bifunctional ligands for opioid and melanocortin 4 receptor.
Advances in experimental medicine and biology 2009;611():195-6.
2008: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Josephine Lai; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Victor J Hruby
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(20):6334-47.
2008: Richard S Agnes; Jinfa Ying; Katalin E Kövér; Yeon Sun Lee; Peg Davis; Shou-wu Ma; Hamid Badghisi; Frank Porreca; Josephine Lai; Victor J Hruby
Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
Peptides 2008;29(8):1413-23.
2008: Takashi Yamamoto; Padma Nair; Josef Vagner; Tally Largent-Milnes; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Suneeta Tumati; Josephine Lai; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Victor J Hruby
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(5):1369-76.
2008: Yeon Sun Lee; Richard S Agnes; James P Cain; Vinod Kulkarni; Minying Cai; Christine Salibay; Kathy Ciano; Ravil R Petrov; Alexander V Mayorov; Josef Vagner; Dev Trivedi; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Opioid and melanocortin receptors: do they have overlapping pharmacophores?
Biopolymers 2008;90(3):433-8.
2007: Yeon Sun Lee; Ravil R Petrov; chad park; Shou-wu Ma; Peg Davis; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.
Journal of medicinal chemistry 2007;50(22):5528-32.
2007: Adriano Mollica; Giovanni Guardiani; Peg Davis; Shou-wu Ma; Frank Porreca; Josephine Lai; Luisa Mannina; Anatoli P Sobolev; Victor J Hruby
Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.
Journal of medicinal chemistry 2007;50(13):3138-42.
2007: Takashi Yamamoto; Padma Nair; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Suneeta Tumati; Josephine Lai; Todd W Vanderah; Henry I Yamamura; Frank Porreca; Victor J Hruby
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Journal of medicinal chemistry 2007;50(12):2779-86.
2007: Yeon Sun Lee; Joel Nyberg; Sharif Moye; Richard S Agnes; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.
Bioorganic & medicinal chemistry letters 2007;17(8):2161-5.
2007: Yeon Sun Lee; Richard S Agnes; Peg Davis; Shou-wu Ma; Hamid Badghisi; Josephine Lai; Frank Porreca; Victor J Hruby
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.
Journal of medicinal chemistry 2007;50(1):165-8.
2006: Ravil R Petrov; Ruben Vardanyan; Yeon S Lee; Shou-wu Ma; Peg Davis; Lucinda J Begay; Josephine Y Lai; Frank Porreca; Victor J Hruby
Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.
Bioorganic & medicinal chemistry letters 2006;16(18):4946-50.
2006: Richard S Agnes; Yeon Sun Lee; Peg Davis; Shou-wu Ma; Hamid Badghisi; Frank Porreca; Josephine Lai; Victor J Hruby
Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
Journal of medicinal chemistry 2006;49(10):2868-75.
2006: Yeon Sun Lee; Richard S Agnes; Hamid Badghisi; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Victor J Hruby
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.
Journal of medicinal chemistry 2006;49(5):1773-80.
2006: Adriano Mollica; Peg Davis; Shou-wu Ma; Frank Porreca; Josephine Lai; Victor J Hruby
Synthesis and biological activity of the first cyclic biphalin analogues.
Bioorganic & medicinal chemistry letters 2006;16(2):367-72.
2005: Adriano Mollica; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Victor J Hruby
Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers.
Bioorganic & medicinal chemistry letters 2005;15(10):2471-5.
2005: Miaw-Chyi Luo; Dong-Qin Zhang; Shou-wu Ma; Yuan-Yuan Huang; Sam J Shuster; Frank Porreca; Josephine Lai
An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons.
Molecular pain 2005;1():29.
2003: Victor J Hruby; Richard S Agnes; Peg Davis; Shou-wu Ma; Yeon Sun Lee; Todd W Vanderah; Josephine Lai; Frank Porreca
Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain.
Life sciences 2003;73(6):699-704.