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Yongsheng Ma

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Yongsheng Ma; Shan Zeng; Dean D Metcalfe; Cem Akin; Sasa Dimitrijevic; Joseph H Butterfield; Gerald McMahon; B Jack Longley
The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations.
B Jack Longley; M J Reguera; Yongsheng Ma
Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy.
B Jack Longley; Yongsheng Ma; E Carter; Gerald McMahon
New approaches to therapy for mastocytosis. A case for treatment with kit kinase inhibitors.

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All Publications

2002: Yongsheng Ma; Shan Zeng; Dean D Metcalfe; Cem Akin; Sasa Dimitrijevic; Joseph H Butterfield; Gerald McMahon; B Jack Longley
The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations.
Blood 2002;99(5):1741-4.
2001: B Jack Longley; M J Reguera; Yongsheng Ma
Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy.
Leukemia research 2001;25(7):571-6.
2000: B Jack Longley; Yongsheng Ma; E Carter; Gerald McMahon
New approaches to therapy for mastocytosis. A case for treatment with kit kinase inhibitors.
Hematology/oncology clinics of North America 2000;14(3):689-95.
2000: Yongsheng Ma; E Carter; Xiuhua Wang; C Shu; Gerald McMahon; B Jack Longley
Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells.
The Journal of investigative dermatology 2000;114(2):392-4.
1999: Yongsheng Ma; ME Cunningham; Xiuhua Wang; I Ghosh; L Regan; B Jack Longley
Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region.
The Journal of biological chemistry 1999;274(19):13399-402.
1999: B Jack Longley; Dean D Metcalfe; Michael D Tharp; Xiuhua Wang; Lynda Tyrrell; S Z Lu; D Heitjan; Yongsheng Ma
Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1609-14.
1999: Yongsheng Ma; B Jack Longley; Xiuhua Wang; JL Blount; KE Langley; George H Caughey
Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms.
The Journal of investigative dermatology 1999;112(2):165-70.

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