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Jon Mabley

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Jon G Mabley; Pal Pacher; Kanneganti G K Murthy; William Williams; Garry J Southan; Andrew L Salzman; Csaba Szabó
The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury.
Jon G Mabley; Pal Pacher; Csaba Szabó
Activation of the cholinergic antiinflammatory pathway reduces ricin-induced mortality and organ failure in mice.
Jon G Mabley; Pal Pacher; Kanneganti G K Murthy; William Williams; Garry J Southan; Andrew L Salzman; Csaba Szabó
The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes.

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2009: Jon G Mabley; Pal Pacher; Kanneganti G K Murthy; William Williams; Garry J Southan; Andrew L Salzman; Csaba Szabó
The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury.
Shock (Augusta, Ga.) 2009;32(3):258-62.
2009: Jon G Mabley; Pal Pacher; Csaba Szabó
Activation of the cholinergic antiinflammatory pathway reduces ricin-induced mortality and organ failure in mice.
Molecular medicine (Cambridge, Mass.) 2009;15(5-6):166-72.
2008: Jon G Mabley; Pal Pacher; Kanneganti G K Murthy; William Williams; Garry J Southan; Andrew L Salzman; Csaba Szabó
The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes.
The Journal of endocrinology 2008;198(3):581-9.
2007: Zoltán H Németh; David Bleich; Balázs Csóka; Pal Pacher; Jon G Mabley; Leonóra Himer; E Sylvester Vizi; Edwin A Deitch; Csaba Szabó; Bruce N Cronstein; György Haskó
Adenosine receptor activation ameliorates type 1 diabetes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(10):2379-88.
2007: Jon G Mabley; Rebecca Wallace; Pal Pacher; Kanneganti Murphy; Csaba Szabó
Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D.
International journal of molecular medicine 2007;19(6):947-52.
2006: Pal Pacher; Lucas Liaudet; Jon G Mabley; Attila Cziráki; György Haskó; Csaba Szabó
Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure.
International journal of molecular medicine 2006;17(2):369-75.
2005: Jon G Mabley; Eszter M Horváth; Kanneganti G K Murthy; Zsuzsanna Zsengellér; Anne Vaslin; Rita Benko; Márk Kollai; Csaba Szabó
Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation.
The Journal of pharmacology and experimental therapeutics 2005;315(2):812-20.
2005: Prakash Jagtap; Erkan Baloglu; Garry J Southan; Jon G Mabley; Hongshan Li; Jing Zhou; John Van Duzer; Andrew L Salzman; Csaba Szabó
Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.
Journal of medicinal chemistry 2005;48(16):5100-3.
2005: Jon G Mabley; Francisco Garcia Soriano
Role of nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic vascular dysfunction.
Current vascular pharmacology 2005;3(3):247-52.
2005: Irina G Obrosova; Jon G Mabley; Zsuzsanna Zsengellér; Tamara Charniauskaya; Omorodola I Abatan; John T Groves; Csaba Szabó
Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(3):401-3.
2005: Jon G Mabley; Pal Pacher; Amitabha Deb; Rebecca Wallace; Rhoderick H Elder; Csaba Szabó
Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(2):290-2.
2005: Pal Pacher; Irina G Obrosova; Jon G Mabley; Csaba Szabó
Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.
Current medicinal chemistry 2005;12(3):267-75.
2004: Pal Pacher; Jon G Mabley; Lucas Liaudet; Oleg V Evgenov; Anita Marton; György Haskó; Márk Kollai; Csaba Szabó
Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure.
American journal of physiology. Heart and circulatory physiology 2004;287(5):H2132-7.
2004: Pal Pacher; Anne Vaslin; Rita Benko; Jon G Mabley; Lucas Liaudet; György Haskó; Anita Marton; Sandor Batkai; Márk Kollai; Csaba Szabó
A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging.
The Journal of pharmacology and experimental therapeutics 2004;311(2):485-91.
2004: Gwen S Scott; Rhonda B Kean; Tatiana Mikheeva; Marzena J Fabis; Jon G Mabley; Csaba Szabó; D Craig Hooper
The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1053-61.
2004: Jon G Mabley; Pal Pacher; Péter Bai; Rebecca Wallace; Sunali Goonesekera; Laszlo Virag; Garry J Southan; Csaba Szabó
Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways.
Mutation research 2004;548(1-2):107-16.
2004: Jon G Mabley; Garry J Southan; Andrew L Salzman; Csaba Szabó
The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes in vivo and interleukin-1beta-induced suppression of islet insulin secretion in vitro.
Pancreas 2004;28(2):E39-44.
2004: Laszlo Virag; Péter Bai; Istvan Bak; Pal Pacher; Jon G Mabley; Lucas Liaudet; Edina Bakondi; Pál Gergely; Márk Kollai; Csaba Szabó
Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma.
Medical science monitor : international medical journal of experimental and clinical research 2004;10(3):BR77-83.
2004: Kanneganti G K Murthy; Chun-Yang Xiao; Jon G Mabley; Min Chen; Csaba Szabó
Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction.
Shock (Augusta, Ga.) 2004;21(3):230-4.
2004: Katalin Komjáti; Jon G Mabley; Laszlo Virag; Garry J Southan; Andrew L Salzman; Csaba Szabó
Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke.
International journal of molecular medicine 2004;13(3):373-82.
2004: Kazunori Murakami; Perenlei Enkhbaatar; Katsumi Shimoda; Robert A Cox; Ann S Burke; Hal K Hawkins; Lillian D Traber; Frank C Schmalstieg; Andrew L Salzman; Jon G Mabley; Katalin Komjáti; Pal Pacher; Zsuzsanna Zsengellér; Csaba Szabó; Daniel L Traber
Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis.
Shock (Augusta, Ga.) 2004;21(2):126-33.
2004: Péter Bai; Jon G Mabley; Lucas Liaudet; Laszlo Virag; Csaba Szabó; Pal Pacher
Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity.
Oncology reports 2004;11(2):505-8.
2004: Prakash Jagtap; Garry J Southan; Erkan Baloglu; Siya Ram; Jon G Mabley; Anita Marton; Andrew L Salzman; Csaba Szabó
The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).
Bioorganic & medicinal chemistry letters 2004;14(1):81-5.
2004: Csaba Szabó; Pal Pacher; Zsuzsanna Zsengellér; Anne Vaslin; Katalin Komjáti; Rita Benkö; Min Chen; Jon G Mabley; Márk Kollai
Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation.
Molecular medicine (Cambridge, Mass.) 2004;10(1-6):28-35.
2003: Pal Pacher; Jon G Mabley; Lucas Liaudet; Oleg V Evgenov; Garry J Southan; GE Abdelkarim; Csaba Szabó; Andrew L Salzman
Topical administration of a novel nitric oxide donor, linear polyethylenimine-nitric oxide/nucleophile adduct (DS1), selectively increases vaginal blood flow in anesthetized rats.
International journal of impotence research 2003;15(6):461-4.
2003: Zsolt Lohinai; Jon G Mabley; Erzsébet Fehér; Anita Marton; Katalin Komjáti; Csaba Szabó
Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis.
Journal of dental research 2003;82(12):987-92.
2003: Oleg V Evgenov; Pal Pacher; William Williams; Natalia V Evgenov; Jon G Mabley; James Cicila; Zsombor B Sikó; Andrew L Salzman; Csaba Szabó
Parenteral administration of glipizide sodium salt, an inhibitor of adenosine triphosphate-sensitive potassium channels, prolongs short-term survival after severe controlled hemorrhage in rats.
Critical care medicine 2003;31(10):2429-36.
2003: Wilma L Suarez-Pinzon; Jon G Mabley; Robert Power; Csaba Szabó; Alex Rabinovitch
Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes.
Diabetes 2003;52(7):1683-8.
2003: Katsumi Shimoda; Kazunori Murakami; Perenlei Enkhbaatar; Lillian D Traber; Robert A Cox; Hal K Hawkins; Frank C Schmalstieg; Katalin Komjati; Jon G Mabley; Csaba Szabó; Andrew L Salzman; Daniel L Traber
Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep.
American journal of physiology. Lung cellular and molecular physiology 2003;285(1):L240-9.
2003: Jon G Mabley; Francisco Soriano; Pal Pacher; György Haskó; Anita Marton; Rebecca Wallace; Andrew L Salzman; Csaba Szabó
The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis.
European journal of pharmacology 2003;466(3):323-9.
2003: Jon G Mabley; Alex Rabinovitch; Wilma L Suarez-Pinzon; György Haskó; Pal Pacher; Robert Power; Garry J Southan; Andrew L Salzman; Csaba Szabó
Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetes.
Molecular medicine (Cambridge, Mass.) 2003;9(3-4):96-104.
2003: Pal Pacher; Lucas Liaudet; Péter Bai; Jon G Mabley; Pawel M Kaminski; Laszlo Virag; Amitabha Deb; Eva Szabó; Zoltán Ungvári; Michael S Wolin; John T Groves; Csaba Szabó
Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction.
Circulation 2003;107(6):896-904.
2003: Lucas Liaudet; Csaba Szabó; Oleg V Evgenov; Kanneganti G K Murthy; Pal Pacher; Laszlo Virag; Jon G Mabley; Anita Marton; Francisco Soriano; Mikhail Y Kirov; Lars J Bjertnaes; Andrew L Salzman
Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis.
Shock (Augusta, Ga.) 2003;19(2):131-7.
2003: Jon G Mabley; Pal Pacher; Lucas Liaudet; Francisco Soriano; György Haskó; Anita Marton; Csaba Szabó; Andrew L Salzman
Inosine reduces inflammation and improves survival in a murine model of colitis.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(1):G138-44.
2002: Jon G Mabley; Lucas Liaudet; Pal Pacher; Garry J Southan; John T Groves; Andrew L Salzman; Csaba Szabó
Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis.
Molecular medicine (Cambridge, Mass.) 2002;8(10):581-90.
2002: Csaba Szabó; Jon G Mabley; Suzanne M Moeller; Roman Shimanovich; Pal Pacher; Laszlo Virag; Francisco Soriano; John Van Duzer; William Williams; Andrew L Salzman; John T Groves
Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst.
Molecular medicine (Cambridge, Mass.) 2002;8(10):571-80.
2002: Jon G Mabley; György Haskó; Lucas Liaudet; Francisco Soriano; F Soriano; Garry J Southan; Andrew L Salzman; Csaba Szabó
NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes.
The Journal of endocrinology 2002;173(3):457-64.
2002: Pal Pacher; Jon G Mabley; Francisco Soriano; Lucas Liaudet; Csaba Szabó
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging.
International journal of molecular medicine 2002;9(6):659-64.
2002: György Haskó; Jon G Mabley; Zoltán H Németh; Pal Pacher; Edwin A Deitch; Csaba Szabó
Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation.
Molecular medicine (Cambridge, Mass.) 2002;8(5):283-9.
2002: Prakash Jagtap; Francisco Soriano; Laszlo Virag; Lucas Liaudet; Jon G Mabley; Eva Szabó; György Haskó; Anita Marton; Clara Batista Lorigados; Ferenc Gallyas Jr; Balázs Sümegi; Dale G Hoyt; Erkan Baloglu; John VanDuzer; Andrew L Salzman; Garry J Southan; Csaba Szabó
Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents.
Critical care medicine 2002;30(5):1071-82.
2002: Francisco Soriano; Lucas Liaudet; Eva Szabó; Laszlo Virag; Jon G Mabley; Pal Pacher; Csaba Szabó
Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice.
Shock (Augusta, Ga.) 2002;17(4):286-92.
2002: Lucas Liaudet; Jon G Mabley; Pal Pacher; Laszlo Virag; Francisco Soriano; Anita Marton; György Haskó; Edwin A Deitch; Csaba Szabó
Inosine exerts a broad range of antiinflammatory effects in a murine model of acute lung injury.
Annals of surgery 2002;235(4):568-78.
2002: Pal Pacher; Jon G Mabley; Francisco Soriano; Lucas Liaudet; Katalin Komjáti; Csaba Szabó
Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation.
British journal of pharmacology 2002;135(6):1347-50.
2002: Lucas Liaudet; Pal Pacher; Jon G Mabley; Laszlo Virag; Francisco Soriano; György Haskó; Csaba Szabó
Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation.
American journal of respiratory and critical care medicine 2002;165(3):372-7.
2002: Pal Pacher; Lucas Liaudet; Francisco Soriano; Jon G Mabley; Eva Szabó; Csaba Szabó
The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes.
Diabetes 2002;51(2):514-21.
2002: Lucas Liaudet; Kanneganti G K Murthy; Jon G Mabley; Pal Pacher; Francisco Soriano; Andrew L Salzman; Csaba Szabó
Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide.
Infection and immunity 2002;70(1):192-8.
2001: Jon G Mabley; Prakash Jagtap; M Perretti; S J Getting; Andrew L Salzman; Laszlo Virag; Eva Szabó; Francisco Soriano; Lucas Liaudet; GE Abdelkarim; György Haskó; Anita Marton; Garry J Southan; Csaba Szabó
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2001;50(11):561-9.
2001: Francisco Soriano; Pal Pacher; Jon G Mabley; Lucas Liaudet; Csaba Szabó
Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase.
Circulation research 2001;89(8):684-91.
2001: Lucas Liaudet; Jon G Mabley; Francisco Soriano; Pal Pacher; Anita Marton; György Haskó; Csaba Szabó
Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture.
American journal of respiratory and critical care medicine 2001;164(7):1213-20.
2001: Wilma L Suarez-Pinzon; Jon G Mabley; Ken Strynadka; RF Power; Csaba Szabó; Alex Rabinovitch
An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice.
Journal of autoimmunity 2001;16(4):449-55.
2000: Lucas Liaudet; Francisco Soriano; Eva Szabó; Laszlo Virag; Jon G Mabley; Andrew L Salzman; Csaba Szabó
Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10203-8.