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Kamel Mabrouk

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Nadège Handké; Kamel Mabrouk; Marion Rollet; Denis Bertin; Thierry Delair; Damien Ficheux; Didier Gigmes; Bernard Verrier; Thomas Trimaille
Lysine-tagged peptide coupling onto polylactide nanoparticles coated with activated ester-based amphiphilic copolymer: a route to highly peptide-functionalized biodegradable carriers.
Maram Morjen; Houcemeddine Othman; Libia Sanz; Najet Srairi-Abid; Raoudha Zouari-Kessentini; Amine Bazaa; Juan José Calvete; Mohamed El Ayeb; Olfa Kallech-Ziri; José Luis; Kamel Mabrouk; Naziha Marrakchi
PIVL, a new serine protease inhibitor from Macrovipera lebetina transmediterranea venom, impairs motility of human glioblastoma cells.
Ilhem Rjeibi; Kamel Mabrouk; Hend Mosrati; Caroline Berenguer; Hafedh Mejdoub; Claude Villard; Daniel Laffitte; Denis Bertin; L'Houcine Ouafik; José Luis; Mohamed Elayeb; Najet Srairi-Abid
Purification, synthesis and characterization of AaCtx, the first chlorotoxin-like peptide from Androctonus australis scorpion venom.

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All Publications

2013: Nadège Handké; Kamel Mabrouk; Marion Rollet; Denis Bertin; Thierry Delair; Damien Ficheux; Didier Gigmes; Bernard Verrier; Thomas Trimaille
Lysine-tagged peptide coupling onto polylactide nanoparticles coated with activated ester-based amphiphilic copolymer: a route to highly peptide-functionalized biodegradable carriers.
Colloids and surfaces. B, Biointerfaces 2013;103():298-303.
2013: Maram Morjen; Houcemeddine Othman; Libia Sanz; Najet Srairi-Abid; Raoudha Zouari-Kessentini; Amine Bazaa; Juan José Calvete; Mohamed El Ayeb; Olfa Kallech-Ziri; José Luis; Kamel Mabrouk; Naziha Marrakchi
PIVL, a new serine protease inhibitor from Macrovipera lebetina transmediterranea venom, impairs motility of human glioblastoma cells.
Matrix biology : journal of the International Society for Matrix Biology 2013;32(1):52-62.
2011: Ilhem Rjeibi; Kamel Mabrouk; Hend Mosrati; Caroline Berenguer; Hafedh Mejdoub; Claude Villard; Daniel Laffitte; Denis Bertin; L'Houcine Ouafik; José Luis; Mohamed Elayeb; Najet Srairi-Abid
Purification, synthesis and characterization of AaCtx, the first chlorotoxin-like peptide from Androctonus australis scorpion venom.
Peptides 2011;32(4):656-63.
2007: Kamel Mabrouk; Narendra Ram; Sylvie Boisseau; Flavie Strappazzon; Amel Rehaim; Rémy Sadoul; Hervé Darbon; Michel Ronjat; Michel De Waard
Critical amino acid residues of maurocalcine involved in pharmacology, lipid interaction and cell penetration.
Biochimica et biophysica acta 2007;1768(10):2528-40.
2007: Xavier Altafaj; Julien France; Janos Almassy; Istvan Jona; Daniela Rossi; Vincenzo Sorrentino; Kamel Mabrouk; Michel De Waard; Michel Ronjat
Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification.
The Biochemical journal 2007;406(2):309-15.
2006: Sylvie Boisseau; Kamel Mabrouk; Narendra Ram; Nicolas Garmy; Véronique Collin; Abir Tadmouri; Mohamad A Mikati; Jean-Marc Sabatier; Michel Ronjat; Jacques Fantini; Michel De Waard
Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor.
Biochimica et biophysica acta 2006;1758(3):308-19.
2005: Eric Estève; Kamel Mabrouk; Alain Dupuis; Sophia Smida-Rezgui; Xavier Altafaj; Didier Grunwald; jeanclaude platel; nicolas andreotti; Isabelle Marty; Jean-Marc Sabatier; Michel Ronjat; Michel De Waard
Transduction of the scorpion toxin maurocalcine into cells. Evidence that the toxin crosses the plasma membrane.
The Journal of biological chemistry 2005;280(13):12833-9.
2004: Besma Jouirou; Amor Mosbah; Violeta Visan; Stephan Grissmer; Sarrah M'barek; Ziad Fajloun; Jurphaas van Rietschoten; Christiane Devaux; Hervé Rochat; Guy Lippens; Mohamed El Ayeb; Michel De Waard; Kamel Mabrouk; Jean-Marc Sabatier
Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels.
The Biochemical journal 2004;377(Pt 1):37-49.
2002: Mohamed Fathallah; guillaume sandoz; Kamel Mabrouk; Sandrine Geib; Julie Urbani; Michel Villaz; Michel Ronjat; Jean-Marc Sabatier; Michel De Waard
Modelling of the III-IV loop, a domain involved in calcium channel Ca(v)2.1 inactivation, highlights a structural homology with the gamma subunit of G proteins.
The European journal of neuroscience 2002;16(2):219-28.
2002: Jean de Mareuil; Kamel Mabrouk; Evelyne Doria; Maxime Moulard; Stéphanie de Chasteigner; Razika Oughideni; Jurphaas van Rietschoten; Hervé Rochat; Michel De Waard; Jean-Marc Sabatier
Liposomal encapsulation enhances antiviral efficacy of SPC3 against human immunodeficiency virus type-1 infection in human lymphocytes.
Antiviral research 2002;54(3):175-88.
2002: Sandrine Geib; guillaume sandoz; Kamel Mabrouk; Alessandra Matavel; Pascale Marchot; Toshinori Hoshi; Michel Villaz; Michel Ronjat; Raymond Miquelis; Christian Lévêque; Michel De Waard
Use of a purified and functional recombinant calcium-channel beta4 subunit in surface-plasmon resonance studies.
The Biochemical journal 2002;364(Pt 1):285-92.
2002: Sandrine Geib; guillaume sandoz; Véronique Cornet; Kamel Mabrouk; Odile Fund-Saunier; Delphine Bichet; Michel Villaz; Toshinori Hoshi; Jean-Marc Sabatier; Michel De Waard
The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner.
The Journal of biological chemistry 2002;277(12):10003-13.
2001: M Ferchichi; Jacques Frère; Kamel Mabrouk; Mohamed Manai
Lactococcin MMFII, a novel class IIa bacteriocin produced by Lactococcus lactis MMFII, isolated from a Tunisian dairy product.
FEMS microbiology letters 2001;205(1):49-55.
2001: M Ferchichi; Mohamed Fathallah; Pascal Mansuelle; Hervé Rochat; Jean-Marc Sabatier; Mohamed Manai; Kamel Mabrouk
Chemical synthesis, molecular modeling, and antimicrobial activity of a novel bacteriocin, MMFII.
Biochemical and biophysical research communications 2001;289(1):13-8.
2001: Naziha Marrakchi; Kamel Mabrouk; Imed Regaya; Sameh Sarray; Mohamed Fathallah; Hervé Rochat; Mohamed El Ayeb
Lebetin peptides: potent platelet aggregation inhibitors.
Haemostasis 2001;31(3-6):207-10.
2000: Edmond Carlier; Kamel Mabrouk; Maxime Moulard; Ziad Fajloun; Hervé Rochat; Michel De Waard; Jean-Marc Sabatier
Ion channel activation by SPC3, a peptide derived from the HIV-1 gp120 V3 loop.
The journal of peptide research : official journal of the American Peptide Society 2000;56(6):427-37.
2000: Ziad Fajloun; Edmond Carlier; C Lecomte; Sandrine Geib; eric di Luccio; Delphine Bichet; Kamel Mabrouk; Hervé Rochat; Michel De Waard; Jean-Marc Sabatier
Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels.
European journal of biochemistry / FEBS 2000;267(16):5149-55.
2000: Ziad Fajloun; Gilles Ferrat; Edmond Carlier; Mohamed Fathallah; C Lecomte; guillaume sandoz; eric di Luccio; Kamel Mabrouk; Christian Legros; Hervé Darbon; Hervé Rochat; Jean-Marc Sabatier; Michel De Waard
Synthesis, 1H NMR structure, and activity of a three-disulfide-bridged maurotoxin analog designed to restore the consensus motif of scorpion toxins.
The Journal of biological chemistry 2000;275(18):13605-12.
1999: Maxime Moulard; Kamel Mabrouk; I Martin; Jurphaas van Rietschoten; Hervé Rochat; Jean-Marc Sabatier
V3 loop-derived peptide SPC3 inhibits infection of CD4- and galactosylceramide- cells by LAV-2/B.
The journal of peptide research : official journal of the American Peptide Society 1999;53(6):647-55.
1998: Rym Barbouche; Naziha Marrakchi; Kamel Mabrouk; Mohamed Naceur Krifi; Jurphaas van Rietschoten; Emmanuel Fenouillet; Mohamed El Ayeb; Hervé Rochat
Anti-platelet activity of the peptides composing the lebetin 1 family, a new class of inhibitors of platelet aggregation.
Toxicon : official journal of the International Society on Toxinology 1998;36(12):1939-47.
1998: Hervé Rochat; Riadh Kharrat; Jean-Marc Sabatier; Pascal Mansuelle; Marcel Crest; Marie-France Martin-Eauclaire; François Sampieri; Razika Oughideni; Kamel Mabrouk; Guy Jacquet; Jurphaas van Rietschoten; Mohamed El Ayeb
Maurotoxin, a four disulfide bridges scorpion toxin acting on K+ channels.
Toxicon : official journal of the International Society on Toxinology 1998;36(11):1609-11.
1998: Maxime Moulard; L Chaloin; S Canarelli; Kamel Mabrouk; Hervé Darbon; L Challoin
Retroviral envelope glycoprotein processing: structural investigation of the cleavage site.
Biochemistry 1998;37(13):4510-7.
1997: Christiane Devaux; Olivier Clot-Faybesse; MA Juin; Kamel Mabrouk; Jean-Marc Sabatier; Hervé Rochat
Monoclonal antibodies neutralizing the toxin II from Androctonus australis hector scorpion venom: usefulness of a synthetic, non-toxic analog.
FEBS letters 1997;412(3):456-60.
1996: Riadh Kharrat; Kamel Mabrouk; Marcel Crest; Hervé Darbon; Razika Oughideni; Marie-France Martin-Eauclaire; Guy Jacquet; Mohamed El Ayeb; Jurphaas van Rietschoten; Hervé Rochat; Jean-Marc Sabatier
Chemical synthesis and characterization of maurotoxin, a short scorpion toxin with four disulfide bridges that acts on K+ channels.
European journal of biochemistry / FEBS 1996;242(3):491-8.
1996: Jean-Marc Sabatier; Kamel Mabrouk; Maxime Moulard; Hervé Rochat; Jurphaas van Rietschoten; Emmanuel Fenouillet
Anti-HIV activity of multibranched peptide constructs derived either from the cleavage sequence or from the transmembrane domain (gp41) of the human immunodeficiency virus type 1 envelope.
Virology 1996;223(2):406-8.
1996: Jean-Marc Sabatier; C Lecomte; Kamel Mabrouk; Hervé Darbon; Razika Oughideni; S Canarelli; Hervé Rochat; Marie-France Martin-Eauclaire; Jurphaas van Rietschoten
Synthesis and characterization of leiurotoxin I analogs lacking one disulfide bridge: evidence that disulfide pairing 3-21 is not required for full toxin activity.
Biochemistry 1996;35(33):10641-7.
1995: Christiane Devaux; M Knibiehler; M L Defendini; Kamel Mabrouk; Hervé Rochat; Jurphaas van Rietschoten; Daniel Baty; Claude Granier
Recombinant and chemical derivatives of apamin. Implication of post-transcriptional C-terminal amidation of apamin in biological activity.
European journal of biochemistry / FEBS 1995;231(3):544-50.
1995: Kamel Mabrouk; Jurphaas van Rietschoten; Hervé Rochat; E P Loret
Correlation of antiviral activity with beta-turn types for V3 synthetic multibranched peptides from HIV-1 gp120.
Biochemistry 1995;34(26):8294-8.
1995: Nouara Yahi; Jacques Fantini; S Baghdiguian; Kamel Mabrouk; Catherine Tamalet; H Rochat; Jurphaas van Rietschoten; Jean-Marc Sabatier
SPC3, a synthetic peptide derived from the V3 domain of human immunodeficiency virus type 1 (HIV-1) gp120, inhibits HIV-1 entry into CD4+ and CD4- cells by two distinct mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4867-71.
1995: Olivier Delezay; B Verrier; Kamel Mabrouk; Jurphaas van Rietschoten; Jacques Fantini; J Mauchamp; C Gerard
Characterization of an electrogenic sodium/glucose cotransporter in a human colon epithelial cell line.
Journal of cellular physiology 1995;163(1):120-8.
1994: Nouara Yahi; Jean-Marc Sabatier; P Nickel; Kamel Mabrouk; F Gonzalez-Scarano; Jacques Fantini
Suramin inhibits binding of the V3 region of HIV-1 envelope glycoprotein gp120 to galactosylceramide, the receptor for HIV-1 gp120 on human colon epithelial cells.
The Journal of biological chemistry 1994;269(39):24349-53.
1994: Nouara Yahi; Jacques Fantini; Kamel Mabrouk; Catherine Tamalet; P de Micco; Jurphaas van Rietschoten; H Rochat; Jean-Marc Sabatier
Multibranched V3 peptides inhibit human immunodeficiency virus infection in human lymphocytes and macrophages.
Journal of virology 1994;68(9):5714-20.
1994: Jean-Marc Sabatier; V Fremont; Kamel Mabrouk; Marcel Crest; Hervé Darbon; Hervé Rochat; Jurphaas van Rietschoten; Marie-France Martin-Eauclaire
Leiurotoxin I, a scorpion toxin specific for Ca(2+)-activated K+ channels. Structure-activity analysis using synthetic analogs.
International journal of peptide and protein research 1994;43(5):486-95.
1994: Abdelaziz Benjouad; Kamel Mabrouk; Jean Claude Gluckman; Emmanuel Fenouillet
Effect of sialic acid removal on the antibody response to the third variable domain of human immunodeficiency virus type-1 envelope glycoprotein.
FEBS letters 1994;341(2-3):244-50.
1993: Jacques Fantini; Nouara Yahi; Kamel Mabrouk; Jurphaas van Rietschoten; H Rochat; Jean-Marc Sabatier
Multi-branched peptides based on the HIV-1 V3 loop consensus motif inhibit HIV-1 and HIV-2 infection in CD4+ and CD4- cells.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1993;316(11):1381-7.
1993: M Tordjeman; G Fontan; V Rabillon; J Martin; C Trepo; A Hoffenbach; Kamel Mabrouk; Jean-Marc Sabatier; Jurphaas van Rietschoten; G Somme
Characterization of minor and major antigenic regions within the hepatitis B virus nucleocapsid.
Journal of medical virology 1993;41(3):221-9.
1993: Kamel Mabrouk; Maxime Moulard; J C Gluckman; R Romi; Hervé Rochat; Jurphaas van Rietschoten; Elmostafa Bahraoui
Evaluation of structure-antigenicity relationship of peptides from human immunodeficiency virus type 1 (HIV-1) p18 protein by circular dichroism.
Molecular immunology 1993;30(5):503-12.
1993: Jean-Marc Sabatier; H Zerrouk; Hervé Darbon; Kamel Mabrouk; A Benslimane; Hervé Rochat; Marie-France Martin-Eauclaire; Jurphaas van Rietschoten
P05, a new leiurotoxin I-like scorpion toxin: synthesis and structure-activity relationships of the alpha-amidated analog, a ligand of Ca(2+)-activated K+ channels with increased affinity.
Biochemistry 1993;32(11):2763-70.
1993: Abdelaziz Benjouad; Kamel Mabrouk; Maxime Moulard; J C Gluckman; Hervé Rochat; Jurphaas van Rietschoten; Jean-Marc Sabatier
Cytotoxic effect on lymphocytes of Tat from human immunodeficiency virus (HIV-1).
FEBS letters 1993;319(1-2):119-24.
1992: Kamel Mabrouk; Abdelaziz Benjouad; J C Gluckman; Hervé Rochat; Jurphaas van Rietschoten; Elmostafa Bahraoui
Specificity of anti-P25 antibodies produced against whole HIV-1 particles or soluble forms of the protein.
Molecular immunology 1992;29(11):1309-18.
1991: Kamel Mabrouk; Jurphaas van Rietschoten; E Vives; Hervé Darbon; Hervé Rochat; Jean-Marc Sabatier
Lethal neurotoxicity in mice of the basic domains of HIV and SIV Rev proteins. Study of these regions by circular dichroism.
FEBS letters 1991;289(1):13-7.
1991: Jean-Marc Sabatier; E Vives; Kamel Mabrouk; Abdelaziz Benjouad; Hervé Rochat; A Duval; Bernard Hue; Elmostafa Bahraoui
Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1.
Journal of virology 1991;65(2):961-7.
1990: Jean-Marc Sabatier; G Fontan; E Loret; Kamel Mabrouk; Hervé Rochat; Jean Claude Gluckman; Luc Montagnier; Claude Granier; Elmostafa Bahraoui; Jurphaas van Rietschoten
Large fragments of nef-protein and gp110 envelope glycoprotein from HIV-1. Synthesis, CD analysis and immunoreactivity.
International journal of peptide and protein research 1990;35(1):63-72.
1990: Luc Montagnier; D Berneman; Denise Guétard; Alain Blanchard; S Chamaret; V Rame; Jurphaas van Rietschoten; Kamel Mabrouk; Elmostafa Bahraoui
[Infectivity inhibition of HIV prototype strains by antibodies directed against a peptide sequence of mycoplasma].
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1990;311(12):425-30.