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Valentine Macaulay

Research Profile

Chemicals & Drugs

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RNA Interference

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Publications

TOP 3
Valentine M Macaulay; D Mery-Mignard; Mark R Middleton; Andrew Protheroe; C Sessa; R Bahleda; J-Y Blay; V Dieras; P LoRusso; A Tolcher; J-C Soria
Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors.
Benjamin W Turney; Yong Wang; Andrew Protheroe; Johann Riedemann; Mark A Rochester; Simon F Brewster; Meenali M Chitnis; Martin Kerr; Kunal Lodhia; Valentine M Macaulay
Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks.
Benjamin W Turney; Gareth D H Turner; Simon F Brewster; Valentine M Macaulay
Serial analysis of resected prostate cancer suggests up-regulation of type 1 IGF receptor with disease progression.

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All Publications

2013: Valentine M Macaulay; D Mery-Mignard; Mark R Middleton; Andrew Protheroe; C Sessa; R Bahleda; J-Y Blay; V Dieras; P LoRusso; A Tolcher; J-C Soria
Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2013;24(3):784-91.
2012: Benjamin W Turney; Yong Wang; Andrew Protheroe; Johann Riedemann; Mark A Rochester; Simon F Brewster; Meenali M Chitnis; Martin Kerr; Kunal Lodhia; Valentine M Macaulay
Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2012;103(3):402-9.
2011: Benjamin W Turney; Gareth D H Turner; Simon F Brewster; Valentine M Macaulay
Serial analysis of resected prostate cancer suggests up-regulation of type 1 IGF receptor with disease progression.
BJU international 2011;107(9):1488-99.
2009: John S P Yuen; Erdem Akkaya; Yong Wang; Megumi Takiguchi; Sandra Peak; Mark Sullivan; Andrew S Protheroe; Valentine M Macaulay
Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer.
Molecular cancer therapeutics 2009;8(6):1448-59.
2008: John S P Yuen; Valentine M Macaulay
Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer.
Expert opinion on therapeutic targets 2008;12(5):589-603.
2007: Mark A Rochester; Nilay Patel; Benjamin W Turney; David R Davies; Ian S D Roberts; Jeremy P Crew; Andrew Protheroe; Valentine M Macaulay
The type 1 insulin-like growth factor receptor is over-expressed in bladder cancer.
BJU international 2007;100(6):1396-401.
2007: J S P Yuen; Matthew E Cockman; M Sullivan; Andrew Protheroe; Gareth D H Turner; Ian S D Roberts; Christopher W Pugh; H Werner; Valentine M Macaulay
The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma.
Oncogene 2007;26(45):6499-508.
2007: Johann Riedemann; Muhammad Sohail; Valentine M Macaulay
Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells.
Biochemical and biophysical research communications 2007;355(3):700-6.
2007: Johann Riedemann; Megumi Takiguchi; Muhammad Sohail; Valentine M Macaulay
The EGF receptor interacts with the type 1 IGF receptor and regulates its stability.
Biochemical and biophysical research communications 2007;355(3):707-14.
2006: Johann Riedemann; Valentine M Macaulay
IGF1R signalling and its inhibition.
Endocrine-related cancer 2006;13 Suppl 1():S33-43.
2006: A H Yeh; Erin A Bohula; Valentine M Macaulay
Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs.
Oncogene 2006;25(50):6574-81.
2005: Mark A Rochester; Johann Riedemann; Giles O Hellawell; Simon F Brewster; Valentine M Macaulay
Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer.
Cancer gene therapy 2005;12(1):90-100.
2004: Valentine M Macaulay
The IGF receptor as anticancer treatment target.
Novartis Foundation symposium 2004;262():235-43; discussion 243-6, 265-8.
2003: Amanda J Salisbury; Valentine M Macaulay
Development of molecular agents for IGF receptor targeting.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(11-12):843-9.
2003: Erin A Bohula; Martin P Playford; Valentine M Macaulay
Targeting the type 1 insulin-like growth factor receptor as anti-cancer treatment.
Anti-cancer drugs 2003;14(9):669-82.
2003: Erin A Bohula; Amanda J Salisbury; Muhammad Sohail; Martin P Playford; Johann Riedemann; Edwin M Southern; Valentine M Macaulay
The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript.
The Journal of biological chemistry 2003;278(18):15991-7.
2003: Muhammad Sohail; Graeme Doran; Johann Riedemann; Valentine M Macaulay; Edwin M Southern
A simple and cost-effective method for producing small interfering RNAs with high efficacy.
Nucleic acids research 2003;31(7):e38.
2003: Giles O Hellawell; David J P Ferguson; Simon F Brewster; Valentine M Macaulay
Chemosensitization of human prostate cancer using antisense agents targeting the type 1 insulin-like growth factor receptor.
BJU international 2003;91(3):271-7.
2002: Giles O Hellawell; Gareth D H Turner; David R Davies; Richard Poulsom; Simon F Brewster; Valentine M Macaulay
Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease.
Cancer research 2002;62(10):2942-50.
2002: Andrew Bassim Hassan; Valentine M Macaulay
The insulin-like growth factor system as a therapeutic target in colorectal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13(3):349-56.
2001: Valentine M Macaulay; Amanda J Salisbury; Erin A Bohula; Martin P Playford; Nechama I Smorodinsky; Yosef Shiloh
Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase.
Oncogene 2001;20(30):4029-40.
2000: Martin P Playford; David C Bicknell; Walter F Bodmer; Valentine M Macaulay
Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12103-8.