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Gregory MacEwen

Research Profile

Living Beings

Dogs
Cats

Disorders

Chemicals & Drugs

Anatomy

Tumor Cells, Cultured

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Publications

TOP 3
Douglas Thamm; Erin B Dickerson; Nasim Akhtar; Rachel Lewis; Robert Auerbach; Stuart C Helfand; E Gregory MacEwen
Biological and molecular characterization of a canine hemangiosarcoma-derived cell line.
A N Alexander; Mike Huelsmeyer; Ann Mitzey; Richard R Dubielzig; Ilene D Kurzman; E Gregory MacEwen; David M Vail
Development of an allogeneic whole-cell tumor vaccine expressing xenogeneic gp100 and its implementation in a phase II clinical trial in canine patients with malignant melanoma.
Douglas Thamm; Ilene D Kurzman; Ivan King; Zujin Li; Mario Sznol; Richard R Dubielzig; David M Vail; E Gregory MacEwen
Systemic administration of an attenuated, tumor-targeting Salmonella typhimurium to dogs with spontaneous neoplasia: phase I evaluation.

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All Publications

2006: Douglas Thamm; Erin B Dickerson; Nasim Akhtar; Rachel Lewis; Robert Auerbach; Stuart C Helfand; E Gregory MacEwen
Biological and molecular characterization of a canine hemangiosarcoma-derived cell line.
Research in veterinary science 2006;81(1):76-86.
2006: A N Alexander; Mike Huelsmeyer; Ann Mitzey; Richard R Dubielzig; Ilene D Kurzman; E Gregory MacEwen; David M Vail
Development of an allogeneic whole-cell tumor vaccine expressing xenogeneic gp100 and its implementation in a phase II clinical trial in canine patients with malignant melanoma.
Cancer immunology, immunotherapy : CII 2006;55(4):433-42.
2005: Douglas Thamm; Ilene D Kurzman; Ivan King; Zujin Li; Mario Sznol; Richard R Dubielzig; David M Vail; E Gregory MacEwen
Systemic administration of an attenuated, tumor-targeting Salmonella typhimurium to dogs with spontaneous neoplasia: phase I evaluation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4827-34.
2004: E Gregory MacEwen; Josep Pastor; Jonathan Kutzke; Rachel Tsan; Ilene D Kurzman; Douglas Thamm; Mike Wilson; Robert Radinsky
IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma.
Journal of cellular biochemistry 2004;92(1):77-91.
2003: Douglas Thamm; Ilene D Kurzman; E Gregory MacEwen; Rhonda Feinmehl; Todd L Towell; Susan L Longhofer; Christine M Johnson; Frank J Geoly; Dan T Stinchcomb
Intralesional lipid-complexed cytokine/superantigen immunogene therapy for spontaneous canine tumors.
Cancer immunology, immunotherapy : CII 2003;52(8):473-80.
2003: E Gregory MacEwen; Jon Kutzke; Jennifer Carew; Josep Pastor; Julie A Schmidt; Rachel Tsan; Douglas Thamm; Robert Radinsky
c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells.
Clinical & experimental metastasis 2003;20(5):421-30.
2002: Douglas Thamm; E Gregory MacEwen; Brenda S Phillips; A Elizabeth Hershey; Kristine M Burgess; George R Pettit; David M Vail
Preclinical study of dolastatin-10 in dogs with spontaneous neoplasia.
Cancer chemotherapy and pharmacology 2002;49(3):251-5.
2000: Ruthanne Chun; Ilene D Kurzman; C G Couto; J Klausner; C Henry; E Gregory MacEwen
Cisplatin and doxorubicin combination chemotherapy for the treatment of canine osteosarcoma: a pilot study.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2000;14(5):495-8.
2000: Leslie E Fox; R C Rosenthal; R R King; P B Levine; David M Vail; Stuart C Helfand; E Gregory MacEwen; Roman Perez-Soler; M Calderwood-Mays; Ilene D Kurzman
Use of cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II), a liposomal cisplatin analogue, in cats with oral squamous cell carcinoma.
American journal of veterinary research 2000;61(7):791-5.
2000: David M Vail; E Gregory MacEwen
Spontaneously occurring tumors of companion animals as models for human cancer.
Cancer investigation 2000;18(8):781-92.
1999: E Gregory MacEwen; Ilene D Kurzman; David M Vail; Richard R Dubielzig; K Everlith; Bruce R Madewell; Carlos O Rodriguez; B Phillips; C H Zwahlen; Joyce E Obradovich; R C Rosenthal; Leslie E Fox; M Rosenberg; C Henry; J Fidel
Adjuvant therapy for melanoma in dogs: results of randomized clinical trials using surgery, liposome-encapsulated muramyl tripeptide, and granulocyte macrophage colony-stimulating factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4249-58.
1999: S A Soergel; E Gregory MacEwen; David M Vail; D M Potter; Paul M Sondel; Stuart C Helfand
The immunotherapeutic potential of activated canine alveolar macrophages and antitumor monoclonal antibodies in metastatic canine melanoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1999;22(5):443-53.
1999: Ilene D Kurzman; F Shi; David M Vail; E Gregory MacEwen
In vitro and in vivo enhancement of canine pulmonary alveolar macrophage cytotoxic activity against canine osteosarcoma cells.
Cancer biotherapy & radiopharmaceuticals 1999;14(2):121-8.
1999: Leslie E Fox; K Toshach; M Calderwood-Mays; Abdul R Khokhar; Paul S Kubilis; Roman Perez-Soler; E Gregory MacEwen
Evaluation of toxicosis of liposome-encapsulated cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) in clinically normal cats.
American journal of veterinary research 1999;60(2):257-63.
1999: G S Hogge; JK Burkholder; J Culp; Mark R Albertini; Richard R Dubielzig; Ning-Sun Yang; E Gregory MacEwen
Preclinical development of human granulocyte-macrophage colony-stimulating factor-transfected melanoma cell vaccine using established canine cell lines and normal dogs.
Cancer gene therapy 1999;6(1):26-36.
1998: William M Adams; Paul E Miller; David M Vail; Lisa J Forrest; E Gregory MacEwen
An accelerated technique for irradiation of malignant canine nasal and paranasal sinus tumors.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 1998;39(5):475-81.
1998: G S Hogge; JK Burkholder; J Culp; Mark R Albertini; Richard R Dubielzig; Evan T Keller; Ning-Sun Yang; E Gregory MacEwen
Development of human granulocyte-macrophage colony-stimulating factor-transfected tumor cell vaccines for the treatment of spontaneous canine cancer.
Human gene therapy 1998;9(13):1851-61.
1998: Ilene D Kurzman; D L Panciera; J B Miller; E Gregory MacEwen
The effect of dehydroepiandrosterone combined with a low-fat diet in spontaneously obese dogs: a clinical trial.
Obesity research 1998;6(1):20-8.
1997: Lisa J Forrest; Elizabeth Galbreath; Richard R Dubielzig; E Gregory MacEwen
Peripheral neuroblastoma in a dog.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 1997;38(6):457-60.
1997: David M Vail; L D Kravis; A James Cooley; Ruthanne Chun; E Gregory MacEwen
Preclinical trial of doxorubicin entrapped in sterically stabilized liposomes in dogs with spontaneously arising malignant tumors.
Cancer chemotherapy and pharmacology 1997;39(5):410-6.
1996: David M Vail; W C Kisseberth; J E Obradovich; F M Moore; CA London; E Gregory MacEwen; Mark A Ritter
Assessment of potential doubling time (Tpot), argyrophilic nucleolar organizer regions (AgNOR), and proliferating cell nuclear antigen (PCNA) as predictors of therapy response in canine non-Hodgkin's lymphoma.
Experimental hematology 1996;24(7):807-15.
1996: Evan T Keller; JK Burkholder; F Shi; Thomas D Pugh; D McCabe; James S Malter; E Gregory MacEwen; Ning-Sun Yang; William B. Ershler
In vivo particle-mediated cytokine gene transfer into canine oral mucosa and epidermis.
Cancer gene therapy 1996;3(3):186-91.
1996: P J Bergman; E Gregory MacEwen; Ilene D Kurzman; C J Henry; A S Hammer; D W Knapp; A Hale; S A Kruth; M K Klein; J Klausner; A M Norris; Dudley L McCaw; Rodney C Straw; Stephen J Withrow
Amputation and carboplatin for treatment of dogs with osteosarcoma: 48 cases (1991 to 1993).
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 1996;10(2):76-81.
1996: E Gregory MacEwen; Ilene D Kurzman
Canine osteosarcoma: amputation and chemoimmunotherapy.
The Veterinary clinics of North America. Small animal practice 1996;26(1):123-33.
1995: Ilene D Kurzman; E Gregory MacEwen; R C Rosenthal; Leslie E Fox; Evan T Keller; Stuart C Helfand; David M Vail; Richard R Dubielzig; Bruce R Madewell; C O Rodriguez
Adjuvant therapy for osteosarcoma in dogs: results of randomized clinical trials using combined liposome-encapsulated muramyl tripeptide and cisplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(12):1595-601.
1995: W C Kisseberth; E Gregory MacEwen; Stuart C Helfand; David M Vail; C L London; Evan T Keller
Response to liposome-encapsulated doxorubicin (TLC D-99) in a dog with myeloma.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 1995;9(6):425-8.
1995: David M Vail; E Gregory MacEwen; Ilene D Kurzman; Richard R Dubielzig; Stuart C Helfand; W C Kisseberth; CA London; J E Obradovich; Bruce R Madewell; C O Rodriguez
Liposome-encapsulated muramyl tripeptide phosphatidylethanolamine adjuvant immunotherapy for splenic hemangiosarcoma in the dog: a randomized multi-institutional clinical trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(10):1165-70.
1995: Jane Christopher-Hennings; Ilene D Kurzman; A L Haffa; Joseph Kemnitz; E Gregory MacEwen
The effect of high fat diet and dehydroepiandrosterone (DHEA) administration in the rhesus monkey.
In vivo (Athens, Greece) 1995;9(5):415-20.
1995: F Shi; Ilene D Kurzman; E Gregory MacEwen
In vitro and in vivo production of interleukin-6 induced by muramyl peptides and lipopolysaccharide in normal dogs.
Cancer biotherapy 1995;10(4):317-25.
1995: Leslie E Fox; E Gregory MacEwen; Ilene D Kurzman; Richard R Dubielzig; Stuart C Helfand; David M Vail; W Kisseberth; C London; Bruce R Madewell; C O Rodriguez
Liposome-encapsulated muramyl tripeptide phosphatidylethanolamine for the treatment of feline mammary adenocarcinoma--a multicenter randomized double-blind study.
Cancer biotherapy 1995;10(2):125-30.
1994: Erik Teske; P van Heerde; Gerard Rutteman; Ilene D Kurzman; Peter F Moore; E Gregory MacEwen
Prognostic factors for treatment of malignant lymphoma in dogs.
Journal of the American Veterinary Medical Association 1994;205(12):1722-8.
1994: A L Haffa; E Gregory MacEwen; Ilene D Kurzman; Joseph Kemnitz
Hypocholesterolemic effect of exogenous dehydroepiandrosterone administration in the rhesus monkey.
In vivo (Athens, Greece) 1994;8(6):993-7.
1994: Leslie E Fox; R R King; F Shi; Ilene D Kurzman; E Gregory MacEwen; Paul S Kubilis
Induction of serum tumor necrosis factor-alpha and interleukin-6 activity by liposome-encapsulated muramyl tripeptide-phosphatidylethanolamine (L-MTP-PE) in normal cats.
Cancer biotherapy 1994;9(4):329-40.
1994: E Gregory MacEwen; Ilene D Kurzman; Stuart C Helfand; David M Vail; C London; W Kisseberth; R C Rosenthal; Leslie E Fox; Evan T Keller; J Obradovich
Current studies of liposome muramyl tripeptide (CGP 19835A lipid) therapy for metastasis in spontaneous tumors: a progress review.
Journal of drug targeting 1994;2(5):391-6.
1994: Ilene D Kurzman; H Cheng; E Gregory MacEwen
Effect of liposome-muramyl tripeptide combined with recombinant canine granulocyte colony-stimulating factor on canine monocyte activity.
Cancer biotherapy 1994;9(2):113-21.
1993: F Shi; E Gregory MacEwen; Ilene D Kurzman
In vitro and in vivo effect of doxorubicin combined with liposome-encapsulated muramyl tripeptide on canine monocyte activation.
Cancer research 1993;53(17):3986-91.
1993: Evan T Keller; E Gregory MacEwen; R C Rosenthal; Stuart C Helfand; Leslie E Fox
Evaluation of prognostic factors and sequential combination chemotherapy with doxorubicin for canine lymphoma.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 1993;7(5):289-95.
1993: Ilene D Kurzman; F Shi; E Gregory MacEwen
In vitro and in vivo canine mononuclear cell production of tumor necrosis factor induced by muramyl peptides and lipopolysaccharide.
Veterinary immunology and immunopathology 1993;38(1-2):45-56.
1993: David M Vail; Adnan A Elfarra; A James Cooley; D L Panciera; E Gregory MacEwen; S A Soergel
Methimazole as a protectant against cisplatin-induced nephrotoxicity using the dog as a model.
Cancer chemotherapy and pharmacology 1993;33(1):25-30.
1993: B W Smith; Ilene D Kurzman; KT Schultz; C J Czuprynski; E Gregory MacEwen
Muramyl peptides augment the in vitro and in vivo cytostatic activity of canine plastic-adherent mononuclear cells against canine osteosarcoma cells.
Cancer biotherapy 1993;8(2):137-44.
1992: B K Collins; E Gregory MacEwen; Richard R Dubielzig; J F Swanson
Idiopathic granulomatous disease with ocular adnexal and cutaneous involvement in a dog.
Journal of the American Veterinary Medical Association 1992;201(2):313-6.
1992: E Gregory MacEwen; R C Rosenthal; Leslie E Fox; A S Loar; Ilene D Kurzman
Evaluation of L-asparaginase: polyethylene glycol conjugate versus native L-asparaginase combined with chemotherapy. A randomized double-blind study in canine lymphoma.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 1992;6(4):230-4.
1991: E Gregory MacEwen; Ilene D Kurzman
Obesity in the dog: role of the adrenal steroid dehydroepiandrosterone (DHEA).
The Journal of nutrition 1991;121(11 Suppl):S51-5.
1990: E Gregory MacEwen
Spontaneous tumors in dogs and cats: models for the study of cancer biology and treatment.
Cancer metastasis reviews 1990;9(2):125-36.
1990: Leslie E Fox; R C Rosenthal; D C Twedt; Richard R Dubielzig; E Gregory MacEwen; G F Grauer
Plasma histamine and gastrin concentrations in 17 dogs with mast cell tumors.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 1990;4(5):242-6.
1990: E Gregory MacEwen
Biologic response modifiers: the future of cancer therapy?
The Veterinary clinics of North America. Small animal practice 1990;20(4):1055-73.
1990: R C Rosenthal; E Gregory MacEwen
Treatment of lymphoma in dogs.
Journal of the American Veterinary Medical Association 1990;196(5):774-81.
1990: Ilene D Kurzman; E Gregory MacEwen; A L Haffa
Reduction in body weight and cholesterol in spontaneously obese dogs by dehydroepiandrosterone.
International journal of obesity 1990;14(2):95-104.
1990: D L Panciera; E Gregory MacEwen; Clarke E Atkins; W T Bosu; Kent R Refsal; Raymond F Nachreiner
Thyroid function tests in euthyroid dogs treated with L-thyroxine.
American journal of veterinary research 1990;51(1):22-6.
1990: D L Panciera; Clarke E Atkins; W T Bosu; E Gregory MacEwen
Quantitative morphologic study of the pituitary and thyroid glands of dogs administered L-thyroxine.
American journal of veterinary research 1990;51(1):27-31.
1989: E Gregory MacEwen; Ilene D Kurzman; R C Rosenthal; B W Smith; P A Manley; J K Roush; P E Howard
Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide.
Journal of the National Cancer Institute 1989;81(12):935-8.
1989: S C Mooney; A A Hayes; E Gregory MacEwen; R E Matus; A Geary; B A Shurgot
Treatment and prognostic factors in lymphoma in cats: 103 cases (1977-1981).
Journal of the American Veterinary Medical Association 1989;194(5):696-702.
1987: S C Mooney; A A Hayes; R E Matus; E Gregory MacEwen
Renal lymphoma in cats: 28 cases (1977-1984).
Journal of the American Veterinary Medical Association 1987;191(11):1473-7.
1987: E Gregory MacEwen; R Rosenthal; R Matus; A T Viau; A Abuchowski
A preliminary study on the evaluation of asparaginase. Polyethylene glycol conjugate against canine malignant lymphoma.
Cancer 1987;59(12):2011-5.
1987: S C Mooney; Amiya K Patnaik; A A Hayes; E Gregory MacEwen
Generalized lymphadenopathy resembling lymphoma in cats: six cases (1972-1976).
Journal of the American Veterinary Medical Association 1987;190(7):897-900.
1987: E Gregory MacEwen; A A Hayes; R E Matus; Ilene D Kurzman
Evaluation of some prognostic factors for advanced multicentric lymphosarcoma in the dog: 147 cases (1978-1981).
Journal of the American Veterinary Medical Association 1987;190(5):564-8.
1987: C E Leifer; R L Page; R E Matus; Amiya K Patnaik; E Gregory MacEwen
Proliferative glomerulonephritis and chronic active hepatitis with cirrhosis associated with Corynebacterium parvum immunotherapy in a dog.
Journal of the American Veterinary Medical Association 1987;190(1):78-80.
1986: R E Matus; C E Leifer; E Gregory MacEwen; A I Hurvitz
Prognostic factors for multiple myeloma in the dog.
Journal of the American Veterinary Medical Association 1986;188(11):1288-92.
1986: E Gregory MacEwen; Amiya K Patnaik; H J Harvey; A A Hayes; R Matus
Canine oral melanoma: comparison of surgery versus surgery plus Corynebacterium parvum.
Cancer investigation 1986;4(5):397-402.
1985: E Gregory MacEwen; H J Harvey; A K Patnaik; S Mooney; A Hayes; Ilene D Kurzman; W D Hardy
Evaluation of effects of levamisole and surgery on canine mammary cancer.
Journal of biological response modifiers 1985;4(4):418-26.
1985: E Gregory MacEwen; A A Hayes; S Mooney; A Patnaik; Ilene D Kurzman; W D Hardy
Levamisole as adjuvant to chemotherapy for canine lymphosarcoma.
Journal of biological response modifiers 1985;4(4):427-33.
1985: N O Brown; Amiya K Patnaik; E Gregory MacEwen
Canine hemangiosarcoma: retrospective analysis of 104 cases.
Journal of the American Veterinary Medical Association 1985;186(1):56-8.
1984: E Gregory MacEwen; A A Hayes; S Mooney; A K Patnaik; H J Harvey; S Passe; W D Hardy
Evaluation of effect of levamisole on feline mammary cancer.
Journal of biological response modifiers 1984;3(5):541-6.
1984: E Gregory MacEwen; A A Hayes; H J Harvey; Amiya K Patnaik; S Mooney; S Passe
Prognostic factors for feline mammary tumors.
Journal of the American Veterinary Medical Association 1984;185(2):201-4.
1984: E Gregory MacEwen; Amiya K Patnaik; G F Johnson; A I Hurvitz; R A Erlandson; P H Lieberman
Extramedullary plasmacytoma of the gastrointestinal tract in two dogs.
Journal of the American Veterinary Medical Association 1984;184(11):1396-8.
1984: E Gregory MacEwen; Amiya K Patnaik; A I Hurvitz; R Bradley; T F Claypoole; S J Withrow; R A Erlandson; P H Lieberman
Nonsecretory multiple myeloma in two dogs.
Journal of the American Veterinary Medical Association 1984;184(10):1283-6.
1984: Bruce R Gordon; R E Matus; A I Hurvitz; E Gregory MacEwen; Stuart D Saal; K H Stenzel; A L Rubin; H Hyden
Perfusion of plasma over Staphylococcus aureus: release of bacterial products is related to regression of tumor.
Journal of biological response modifiers 1984;3(3):266-70.
1983: R E Matus; C E Leifer; E Gregory MacEwen
Acute lymphoblastic leukemia in the dog: a review of 30 cases.
Journal of the American Veterinary Medical Association 1983;183(8):859-62.
1983: C E Leifer; R E Matus; Amiya K Patnaik; E Gregory MacEwen
Chronic myelogenous leukemia in the dog.
Journal of the American Veterinary Medical Association 1983;183(6):686-9.
1983: R E Matus; C E Leifer; Bruce R Gordon; E Gregory MacEwen; A I Hurvitz
Plasmapheresis and chemotherapy of hyperviscosity syndrome associated with monoclonal gammopathy in the dog.
Journal of the American Veterinary Medical Association 1983;183(2):215-8.
1983: Bruce R Gordon; R E Matus; Stuart D Saal; E Gregory MacEwen; A I Hurvitz; K H Stenzel; A L Rubin
Protein A-independent tumoricidal responses in dogs after extracorporeal perfusion of plasma over Staphylococcus aureus.
Journal of the National Cancer Institute 1983;70(6):1127-33.
1982: C A Calvert; C E Leifer; E Gregory MacEwen
Vincristine for treatment of transmissible venereal tumor in the dog--.
Journal of the American Veterinary Medical Association 1982;181(2):163-4.
1982: E Gregory MacEwen; A K Patnaik; H J Harvey; W B Panko
Estrogen receptors in canine mammary tumors.
Cancer research 1982;42(6):2255-9.
1981: E Gregory MacEwen; A K Patnaik; A A Hayes; R J Wilkins; W D Hardy; R L Kassel; Lloyd J Old
Temporary plasma-induced remission of lymphoblastic leukemia in a dog.
American journal of veterinary research 1981;42(8):1450-2.
1981: E Gregory MacEwen; N O Brown; Amiya K Patnaik; A A Hayes; S Passe
Cyclic combination chemotherapy of canine lymphosarcoma.
Journal of the American Veterinary Medical Association 1981;178(11):1178-81.
1981: H J Harvey; E Gregory MacEwen; D Braun; Amiya K Patnaik; S J Withrow; S Jongeward
Prognostic criteria for dogs with oral melanoma.
Journal of the American Veterinary Medical Association 1981;178(6):580-2.
1980: N O Brown; E Gregory MacEwen; C Clavert
Follow-up on chemotherapy of venereal tumors.
Journal of the American Veterinary Medical Association 1980;177(8):676.
1980: Bruce R Gordon; Scott Moroff; A I Hurvitz; R E Matus; E Gregory MacEwen; R A Good; N K Day
Circulating immune complexes in sera of dogs with benign and malignant breast disease.
Cancer research 1980;40(10):3627-31.
1980: N O Brown; C Calvert; E Gregory MacEwen
Chemotherapeutic management of transmissible venereal tumors in 30 dogs.
Journal of the American Veterinary Medical Association 1980;176(10 Pt 1):983-6.