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Marion MacFarlane

Research Profile

Chemicals & Drugs

Anatomy

Jurkat Cells

Physiology

Enzyme Activation

Co-author Network

Publications

TOP 3
G L Robinson; David Dinsdale; Marion MacFarlane; Kelvin Cain
Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL.
Laura S Dickens; Louise Fairall; Michelle A Hughes; Rebekah Jukes-Jones; Robert S Boyd; Kelvin Cain; Gemma L Robinson; John W R Schwabe; Marion MacFarlane
A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death.
Mahesh Vaishnav; Marion MacFarlane; Martin Dickens
Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.

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All Publications

2012: G L Robinson; David Dinsdale; Marion MacFarlane; Kelvin Cain
Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL.
Oncogene 2012;31(48):4996-5006.
2012: Laura S Dickens; Louise Fairall; Michelle A Hughes; Rebekah Jukes-Jones; Robert S Boyd; Kelvin Cain; Gemma L Robinson; John W R Schwabe; Marion MacFarlane
A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death.
Molecular cell 2012;47(2):291-305.
2011: Mahesh Vaishnav; Marion MacFarlane; Martin Dickens
Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.
Experimental cell research 2011;317(7):1028-39.
2010: Kenneth W Young; Lucia G P Piñón; Dalbir Dhiraj; Davina Twiddy; Marion MacFarlane; John Hickman; Pierluigi Nicotera
Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737.
Neuropharmacology 2010;58(8):1258-67.
2009: Michelle A Hughes; Nicholas Harper; Michael Butterworth; Kelvin Cain; Gerald M Cohen; Marion MacFarlane
Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.
Molecular cell 2009;35(3):265-79.
2008: Nicholas Harper; Marion MacFarlane
Recombinant TRAIL and TRAIL receptor analysis.
Methods in enzymology 2008;446():293-313.
2007: Alessandro Natoni; Marion MacFarlane; Satoshi Inoue; Renata Walewska; Aneela Majid; Deborah Knee; David R Stover; Martin J S Dyer; Gerald M Cohen
TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2.
British journal of haematology 2007;139(4):568-77.
2006: Davina Twiddy; Gerald M Cohen; Marion MacFarlane; Kelvin Cain
Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex.
The Journal of biological chemistry 2006;281(7):3876-88.
2005: Marion MacFarlane; Susan L Kohlhaas; Michael J Sutcliffe; Martin J S Dyer; Gerald M Cohen
TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies.
Cancer research 2005;65(24):11265-70.
2005: Marion MacFarlane; Satoshi Inoue; Susan L Kohlhaas; Aneela Majid; Nicholas Harper; D B J Kennedy; Martin J S Dyer; Gerald M Cohen
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1.
Cell death and differentiation 2005;12(7):773-82.
2004: Satoshi Inoue; Marion MacFarlane; Nicholas Harper; L M C Wheat; Martin J S Dyer; Gerald M Cohen
Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies.
Cell death and differentiation 2004;11 Suppl 2():S193-206.
2004: Marion MacFarlane; Ann C Williams
Apoptosis and disease: a life or death decision.
EMBO reports 2004;5(7):674-8.
2004: Davina Twiddy; David G Brown; colin adrain; Rebekah Jukes; Seamus Martin; Gerald M Cohen; Marion MacFarlane; Kelvin Cain
Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.
The Journal of biological chemistry 2004;279(19):19665-82.
2004: Xiao-Ming Sun; Michael Butterworth; Marion MacFarlane; Wolfgang Dubiel; Aaron Ciechanover; Gerald M Cohen
Caspase activation inhibits proteasome function during apoptosis.
Molecular cell 2004;14(1):81-93.
2003: Nicholas Harper; Michelle A Hughes; Stuart N Farrow; Gerald M Cohen; Marion MacFarlane
Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling.
The Journal of biological chemistry 2003;278(45):44338-47.
2003: Nicholas Harper; Michelle Hughes; Marion MacFarlane; Gerald M Cohen
Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis.
The Journal of biological chemistry 2003;278(28):25534-41.
2003: Marion MacFarlane
TRAIL-induced signalling and apoptosis.
Toxicology letters 2003;139(2-3):89-97.
2002: Marion MacFarlane; Nicholas Harper; Roger T Snowden; Martin J S Dyer; Georgina A Barnett; James Pringle; Gerald M Cohen
Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia.
Oncogene 2002;21(44):6809-18.
2002: Marion MacFarlane; Wendy Merrison; Shawn B Bratton; Gerald M Cohen
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
The Journal of biological chemistry 2002;277(39):36611-6.
2002: Xiao-Ming Sun; Shawn B Bratton; Michael Butterworth; Marion MacFarlane; Gerald M Cohen
Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein.
The Journal of biological chemistry 2002;277(13):11345-51.
2001: L Bouchier-Hayes; H Conroy; H Egan; colin adrain; Emma M Creagh; Marion MacFarlane; Seamus Martin
CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.
The Journal of biological chemistry 2001;276(47):44069-77.
2001: Nicholas Harper; Stuart N Farrow; A Kaptein; Gerald M Cohen; Marion MacFarlane
Modulation of tumor necrosis factor apoptosis-inducing ligand- induced NF-kappa B activation by inhibition of apical caspases.
The Journal of biological chemistry 2001;276(37):34743-52.
2001: Peter Greaves; Richard Edwards; Gerald M Cohen; Marion MacFarlane
"Have you seen this?" Diffuse hepatic apoptosis.
Toxicologic pathology 2001;29(3):398-400.
2001: DL Roberts; Wendy Merrison; Marion MacFarlane; Gerald M Cohen
The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity.
The Journal of cell biology 2001;153(1):221-8.
2000: Marion MacFarlane; Gerald M Cohen; Martin Dickens
JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation.
The Biochemical journal 2000;348 Pt 1():93-101.
2000: Shawn B Bratton; Marion MacFarlane; Kelvin Cain; Gerald M Cohen
Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis.
Experimental cell research 2000;256(1):27-33.
2000: Marion MacFarlane; Wendy Merrison; David Dinsdale; Gerald M Cohen
Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis.
The Journal of cell biology 2000;148(6):1239-54.
2000: Mark J Coldwell; Sally A Mitchell; Mark Stoneley; Marion MacFarlane; Anne E Willis
Initiation of Apaf-1 translation by internal ribosome entry.
Oncogene 2000;19(7):899-905.
2000: Mark Stoneley; SA Chappell; Catherine L Jopling; Martin Dickens; Marion MacFarlane; Anne E Willis
c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis.
Molecular and cellular biology 2000;20(4):1162-9.
1999: Salmaan H Inayat-Hussain; Annuar Bin Osman; Laily Bin Din; AM Ali; Roger T Snowden; Marion MacFarlane; Kelvin Cain
Caspases-3 and -7 are activated in goniothalamin-induced apoptosis in human Jurkat T-cells.
FEBS letters 1999;456(3):379-83.
1999: Xiao-Ming Sun; Marion MacFarlane; J Zhuang; BB Wolf; Douglas R Green; Gerald M Cohen
Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.
The Journal of biological chemistry 1999;274(8):5053-60.
1999: Sek C Chow; EA Slee; Marion MacFarlane; Gerald M Cohen
Caspase-1 is not involved in CD95/Fas-induced apoptosis in Jurkat T cells.
Experimental cell research 1999;246(2):491-500.
1998: J M Chandler; Gerald M Cohen; Marion MacFarlane
Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver.
The Journal of biological chemistry 1998;273(18):10815-8.
1997: Marion MacFarlane; Kelvin Cain; Xiao-Ming Sun; E S Alnemri; Gerald M Cohen
Processing/activation of at least four interleukin-1beta converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells.
The Journal of cell biology 1997;137(2):469-79.
1997: J M Chandler; E S Alnemri; Gerald M Cohen; Marion MacFarlane
Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis.
The Biochemical journal 1997;322 ( Pt 1)():19-23.
1996: EA Slee; H Zhu; Sek C Chow; Marion MacFarlane; D W Nicholson; Gerald M Cohen
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.
The Biochemical journal 1996;315 ( Pt 1)():21-4.
1994: Gerald M Cohen; Xiao-Ming Sun; Howard Fearnhead; Marion MacFarlane; D G Brown; R T Snowden; David Dinsdale
Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):507-16.