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Robert Mach

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Aixiao Li; Shihong Li; Robert R Luedtke; Maninder Malik; Yogesh Mishra; David E Reichert; Michelle Taylor; Qi Wang; Robert H Mach
Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands.
Jinbin Xu; Wenhua Chu; Jinquan Cui; Jinda Fan; Lynne A Jones; Shihong Li; Joel S Perlmutter; Zhude Tu; Suwanna Vangveravong; Ruike Wang; Robert H Mach
Positron emission tomography imaging of dopamine D2 receptors using a highly selective radiolabeled D2 receptor partial agonist.
Farrokh Dehdashti; Feng Gao; Friederike H Kreisel; Richard Laforest; Brian Nussenbaum; Kooresh I Shoghi; Nina Wagner-Johnson; Nina Wagner-Johnston; Rebecca L Aft; Nancy L Bartlett; Amanda F Cashen; Robert H Mach
Assessment of cellular proliferation in tumors by PET using 18F-ISO-1.

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2013: Aixiao Li; Shihong Li; Robert R Luedtke; Maninder Malik; Yogesh Mishra; David E Reichert; Michelle Taylor; Qi Wang; Robert H Mach
Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands.
Bioorganic & medicinal chemistry 2013;21(11):2988-98.
2013: Jinbin Xu; Wenhua Chu; Jinquan Cui; Jinda Fan; Lynne A Jones; Shihong Li; Joel S Perlmutter; Zhude Tu; Suwanna Vangveravong; Ruike Wang; Robert H Mach
Positron emission tomography imaging of dopamine D2 receptors using a highly selective radiolabeled D2 receptor partial agonist.
NeuroImage 2013;71():168-74.
2013: Farrokh Dehdashti; Feng Gao; Friederike H Kreisel; Richard Laforest; Brian Nussenbaum; Kooresh I Shoghi; Nina Wagner-Johnson; Nina Wagner-Johnston; Rebecca L Aft; Nancy L Bartlett; Amanda F Cashen; Robert H Mach
Assessment of cellular proliferation in tumors by PET using 18F-ISO-1.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013;54(3):350-7.
2013: Chang Yang; Rong Zeng; Lynne I Collins; Jennifer L Davis; Roberta Faccio; Robert H Mach; David Piwnica-Worms; Xinming Su; Suwanna Vangveravong; Paras Vora; Katherine N Weilbaecher; Deborah Veis Novack
Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation.
Cancer discovery 2013;3(2):212-23.
2013: Devika P Bagchi; Robert H Mach; Joel S Perlmutter; Zhude Tu; Jinbin Xu; Lihai Yu; Paul T Kotzbauer
Binding of the radioligand SIL23 to α-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent.
PloS one 2013;8(2):e55031.
2012: Robert R Luedtke; Cathy Bell-Horner; Glenn H Dillon; Suzy A Griffin; Ren-Qi Huang; Yogesh Mishra; David E Reichert; Michelle Taylor; Suwanna Vangveravong; Qi Wang; Robert H Mach
Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds.
ACS chemical neuroscience 2012;3(12):1050-62.
2012: Kiran Kumar Solingapuram Sai; Zhude Tu; Michael J Welch; Justin Rothfuss; Kooresh I Shoghi; Wenhua Chu; Brian N Finck; Robert J Gropler; Kun-Eek Kil; Robert H Mach
Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.
Bioorganic & medicinal chemistry letters 2012;22(19):6233-6.
2012: Robert R Luedtke; Robert H Mach; Evelyn Perez; Zhude Tu; Suwanna Vangveravong; Shao-Hua Yang; Ran Liu; James W Simpkins
Neuroprotective effects of high affinity Σ1 receptor selective compounds.
Brain research 2012;1441():17-26.
2012: Chenbo Zeng; J Zhang; Katherine C Chang; Wenhua Chu; Richard Hotchkiss; F Pan; Justin Rothfuss; Zhude Tu; Suwanna Vangveravong; Robert H Mach
Sigma-2 ligands induce tumour cell death by multiple signalling pathways.
British journal of cancer 2012;106(4):693-701.
2012: Jianjun Sun; Jinbin Xu; Nigel J Cairns; Joel S Perlmutter; Robert H Mach
Dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2) and dopamine transporter (DAT) densities in aged human brain.
PloS one 2012;7(11):e49483.
2012: John R Hornick; Robert H Mach; Dirk Spitzer; Suwanna Vangveravong; Carmen Abate; Francesco Berardi; Peter S Goedegebuure; William G Hawkins
Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.
Journal of experimental & clinical cancer research : CR 2012;31():41.
2012: LinLin Tian; HuChuan Xia; Jinbin Xu; Chris A Brown; Morvarid Karimi; Susan K Loftin; Robert H Mach; Joel S Perlmutter
No differential regulation of dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) binding in a primate model of Parkinson disease.
PloS one 2012;7(2):e31439.
2011: Jacquelyn A Brown; Kelly A Diggs-Andrews; Robert H Mach; David F Wozniak; Jinbin Xu; David H Gutmann
PET imaging for attention deficit preclinical drug testing in neurofibromatosis-1 mice.
Experimental neurology 2011;232(2):333-8.
2011: Zhanbin Zhang; Jinbin Xu; Xiaoxia Lu; Robert H Mach; Justin Rothfuss; Zhude Tu
Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.
European journal of medicinal chemistry 2011;46(9):3986-95.
2011: Robert H Mach; Zhude Tu; Jinbin Xu; Shihong Li; Lynne A Jones; Michelle Taylor; Robert R Luedtke; Colin P Derdeyn; Joel S Perlmutter; Mark A Mintun
Endogenous dopamine (DA) competes with the binding of a radiolabeled D₃ receptor partial agonist in vivo: a positron emission tomography study.
Synapse (New York, N.Y.) 2011;65(8):724-32.
2011: Miranda M Lim; David M Holtzman; Jinbin Xu; Robert H Mach
Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum.
Neuroreport 2011;22(10):489-93.
2011: Zhude Tu; Jinbin Xu; Wenhua Chu; Lynne A Jones; Shihong Li; Robert R Luedtke; Robert H Mach
Effect of cyclosporin A on the uptake of D3-selective PET radiotracers in rat brain.
Nuclear medicine and biology 2011;38(5):725-39.
2011: Suwanna Vangveravong; Zhanbin Zhang; Michelle Taylor; Melissa Bearden; Jinbin Xu; Jinquan Cui; Wei Wang; Robert R Luedtke; Robert H Mach
Synthesis and characterization of selective dopamine D₂ receptor ligands using aripiprazole as the lead compound.
Bioorganic & medicinal chemistry 2011;19(11):3502-11.
2011: Wenhua Chu; Justin Rothfuss; Dong Zhou; Robert H Mach
Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay.
Bioorganic & medicinal chemistry letters 2011;21(8):2192-7.
2011: Evan D Kharasch; Suwanna Vangveravong; N Buck; A London; T Kim; J Blood; Robert H Mach
Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil.
Clinical pharmacology and therapeutics 2011;89(4):562-70.
2011: Zhude Tu; Shihong Li; Jinquan Cui; Jinbin Xu; Michelle Taylor; David Ho; Robert R Luedtke; Robert H Mach
Synthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands.
Journal of medicinal chemistry 2011;54(6):1555-64.
2011: Zhude Tu; Jinda Fan; Shihong Li; Lynne A Jones; Jinquan Cui; Prashanth K Padakanti; Jinbin Xu; Dexing Zeng; Kooresh I Shoghi; Joel S Perlmutter; Robert H Mach
Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain.
Bioorganic & medicinal chemistry 2011;19(5):1666-73.
2011: Jinda Fan; Konrad Meissner; Gregory G Gaehle; Shihong Li; Evan D Kharasch; Robert H Mach; Zhude Tu
Automated radiosynthesis of [11C]morphine for clinical investigation.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2011;69(2):431-5.
2011: Byung Hee Han; David H Kim; Robert H Mach; Eric Milner; Ananth K Vellimana; Meng-liang Zhou; Wenhua Chu; Jacob K Greenberg; Gregory J Zipfel
Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy.
Molecular neurodegeneration 2011;6():86.
2011: Jinbin Xu; Chenbo Zeng; Dexing Zeng; Fanjie Zhang; Dong Zhou; Katherine C Chang; Wenhua Chu; William G Hawkins; Richard S Hotchkiss; Fabian Johnston; Fenghui Pan; Justin M Rothfuss; Dirk Spitzer; Zhude Tu; Suwanna Vangveravong; Kenneth T Wheeler; Robert H Mach
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.
Nature communications 2011;2():380.
2011: Morvarid Karimi; Stephen M Moerlein; Tom O Videen; Robert R Luedtke; Michelle Taylor; Robert H Mach; Joel S Perlmutter
Decreased striatal dopamine receptor binding in primary focal dystonia: a D2 or D3 defect?
Movement disorders : official journal of the Movement Disorder Society 2011;26(1):100-6.
2010: Zhude Tu; Shihong Li; Terry L Sharp; Pilar Herrero; Carmen S Dence; Robert J Gropler; Robert H Mach
Synthesis and evaluation of 15-(4-(2-[¹⁸F]Fluoroethoxy)phenyl)pentadecanoic acid: a potential PET tracer for studying myocardial fatty acid metabolism.
Bioconjugate chemistry 2010;21(12):2313-9.
2010: Zhude Tu; Jinbin Xu; Lynne A Jones; Shihong Li; Dexing Zeng; Mei-Ping Kung; Hank F Kung; Robert H Mach
Radiosynthesis and biological evaluation of a promising sigma(2)-receptor ligand radiolabeled with fluorine-18 or iodine-125 as a PET/SPECT probe for imaging breast cancer.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2010;68(12):2268-73.
2010: Carmen S Dence; Richard Laforest; Xiankai Sun; Terry L Sharp; Michael J Welch; Robert H Mach
Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [¹¹C] methylated LY2181308.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2010;12(6):608-15.
2010: Qi Wang; Robert H Mach; Robert R Luedtke; David E Reichert
Subtype selectivity of dopamine receptor ligands: insights from structure and ligand-based methods.
Journal of chemical information and modeling 2010;50(11):1970-85.
2010: Andrei G Vlassenko; S Neil Vaishnavi; Lars Couture; Dana Sacco; Benjamin J Shannon; Robert H Mach; John C Morris; Marcus E Raichle; Mark A Mintun
Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(41):17763-7.
2010: Suwanna Vangveravong; Michelle Taylor; Jinbin Xu; Jinquan Cui; Wesley Calvin; Sonja Babic; Robert R Luedtke; Robert H Mach
Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.
Bioorganic & medicinal chemistry 2010;18(14):5291-300.
2010: Jinbin Xu; Babak Hassanzadeh; Wenhua Chu; Zhude Tu; Lynne A Jones; Robert R Luedtke; Joel S Perlmutter; Mark A Mintun; Robert H Mach
[3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamen.
Synapse (New York, N.Y.) 2010;64(6):449-59.
2010: Zhude Tu; Jinbin Xu; Lynne A Jones; Shihong Li; Robert H Mach
Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation.
Nuclear medicine and biology 2010;37(4):509-16.
2010: S M N Efange; AB Khare; Krystyna von Hohenberg; Robert H Mach; SM Parsons; Zhude Tu
Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter.
Journal of medicinal chemistry 2010;53(7):2825-35.
2010: Chenbo Zeng; Fenghui Pan; Lynne A Jones; Miranda M Lim; Elizabeth A Griffin; Yvette I Sheline; Mark A Mintun; David M Holtzman; Robert H Mach
Evaluation of 5-ethynyl-2'-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system.
Brain research 2010;1319():21-32.
2010: John R Hornick; Jinbin Xu; Suwanna Vangveravong; Zhude Tu; Jonathan B Mitchem; Dirk Spitzer; Peter S Goedegebuure; Robert H Mach; William G Hawkins
The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine.
Molecular cancer 2010;9():298.
2010: Z Tu; Robert H Mach
C-11 radiochemistry in cancer imaging applications.
Current topics in medicinal chemistry 2010;10(11):1060-95.
2009: Anne M Fagan; Mark A Mintun; Aarti R Shah; Patricia Aldea; Catherine M Roe; Robert H Mach; Daniel Marcus; John C Morris; David M Holtzman
Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease.
EMBO molecular medicine 2009;1(8-9):371-80.
2009: Robert H Mach; Kenneth Theodore Wheeler
Development of molecular probes for imaging sigma-2 receptors in vitro and in vivo.
Central nervous system agents in medicinal chemistry 2009;9(3):230-45.
2009: Jinbin Xu; Wenhua Chu; Zhude Tu; Lynne A Jones; Robert R Luedtke; Joel S Perlmutter; Mark A Mintun; Robert H Mach
[(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterization.
Synapse (New York, N.Y.) 2009;63(9):717-28.
2009: Delphine L Chen; Dong Zhou; Wenhua Chu; Phillip E Herrbrich; Lynne A Jones; Justin Rothfuss; Jacquelyn T Engle; Marco Geraci; Michael J Welch; Robert H Mach
Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography.
Nuclear medicine and biology 2009;36(6):651-8.
2009: Qi Wang; Robert H Mach; David E Reichert
Docking and 3D-QSAR studies on isatin sulfonamide analogues as caspase-3 inhibitors.
Journal of chemical information and modeling 2009;49(8):1963-73.
2009: Rakesh Kumar; Lindsay R Riddle; Suzy A Griffin; Wenhua Chu; Suwanna Vangveravong; Janet Neisewander; Robert H Mach; Robert R Luedtke
Evaluation of D2 and D3 dopamine receptor selective compounds on L-dopa-dependent abnormal involuntary movements in rats.
Neuropharmacology 2009;56(6-7):956-69.
2009: Wenhua Chu; Justin Rothfuss; Yunxiang Chu; Dong Zhou; Robert H Mach
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.
Journal of medicinal chemistry 2009;52(8):2188-91.
2009: Dong Zhou; Hsiaoju Lee; Justin Rothfuss; Delphine L Chen; Datta E Ponde; Michael J Welch; Robert H Mach
Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.
Journal of medicinal chemistry 2009;52(8):2443-53.
2009: Dong Zhou; Wenhua Chu; Delphine L Chen; Qi Wang; David E Reichert; Justin Rothfuss; Andre D'Avignon; Michael J Welch; Robert H Mach
[18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98.
Organic & biomolecular chemistry 2009;7(7):1337-48.
2009: Zhude Tu; Simon M N Efange; Jinbin Xu; Shihong Li; Lynne A Jones; Stanley M Parsons; Robert H Mach
Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter.
Journal of medicinal chemistry 2009;52(5):1358-69.
2009: Wenhua Chu; Jinbin Xu; Dong Zhou; Fanjie Zhang; Lynne A Jones; Kenneth T Wheeler; Robert H Mach
New N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl phenylcarbamate analogs as sigma2 receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents.
Bioorganic & medicinal chemistry 2009;17(3):1222-31.
2007: Wenhua Chu; Justin Rothfuss; André d'Avignon; Chenbo Zeng; Dong Zhou; Richard S Hotchkiss; Robert H Mach
Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.
Journal of medicinal chemistry 2007;50(15):3751-5.
2007: Chenbo Zeng; Suwanna Vangveravong; Jinbin Xu; Katherine C Chang; Richard S Hotchkiss; Kenneth T Wheeler; Duanwen Shen; Zhi-Ping Zhuang; Hank F Kung; Robert H Mach
Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy.
Cancer research 2007;67(14):6708-16.
2007: Zhude Tu; Jinbin Xu; Lynne A Jones; Shihong Li; Craig Dumstorff; Suwanna Vangveravong; Delphine L Chen; Kenneth T Wheeler; Michael J Welch; Robert H Mach
Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography.
Journal of medicinal chemistry 2007;50(14):3194-204.
2006: Suwanna Vangveravong; Jinbin Xu; Chenbo Zeng; Robert H Mach
Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl carbamate analogs as sigma2 receptor ligands.
Bioorganic & medicinal chemistry 2006;14(20):6988-97.
2006: Hsiaoju Lee; Brian N Finck; Lynne A Jones; Michael J Welch; Robert H Mach
Synthesis and evaluation of a bromine-76-labeled PPARgamma antagonist 2-bromo-5-nitro-N-phenylbenzamide.
Nuclear medicine and biology 2006;33(7):847-54.
2006: Dong Zhou; Wenhua Chu; Justin Rothfuss; Chenbo Zeng; Jinbin Xu; Lynne Jones; Michael J Welch; Robert H Mach
Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis.
Bioorganic & medicinal chemistry letters 2006;16(19):5041-6.
2006: Mark A Mintun; Gina N LaRossa; Yvette I Sheline; Carmen S Dence; S Y Lee; Robert H Mach; William E Klunk; Chester A Mathis; Steven T DeKosky; John C Morris
[11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease.
Neurology 2006;67(3):446-52.
2006: Michael A Nader; Drake Morgan; H Donald Gage; Susan H Nader; Tonya L Calhoun; Nancy Buchheimer; Richard L Ehrenkaufer; Robert H Mach
PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys.
Nature neuroscience 2006;9(8):1050-6.
2006: Douglas Rowland; Zhude Tu; Jinbin Xu; Datta E Ponde; Robert H Mach; Michael J Welch
Synthesis and in vivo evaluation of 2 high-affinity 76Br-labeled sigma2-receptor ligands.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(6):1041-8.
2006: Anne M Fagan; Mark A Mintun; Robert H Mach; Sang-Yoon Lee; Carmen S Dence; Aarti R Shah; Gina N LaRossa; Michael L Spinner; William E Klunk; Chester A Mathis; Steven T DeKosky; John C Morris; David M Holtzman
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.
Annals of neurology 2006;59(3):512-9.
2006: Suwanna Vangveravong; Elizabeth McElveen; Michelle Taylor; Jinbin Xu; Zhude Tu; Robert R Luedtke; Robert H Mach
Synthesis and characterization of selective dopamine D2 receptor antagonists.
Bioorganic & medicinal chemistry 2006;14(3):815-25.
2005: Robert H Mach; H Donald Gage; Nancy Buchheimer; Yunsheng Huang; Ross Kuhner; Li Wu; Thomas E Morton; Richard L Ehrenkaufer
N-[18F]4'-fluorobenzylpiperidin-4yl-(2-fluorophenyl) acetamide ([18F]FBFPA): a potential fluorine-18 labeled PET radiotracer for imaging sigma-1 receptors in the CNS.
Synapse (New York, N.Y.) 2005;58(4):267-74.
2005: Wenhua Chu; Jun Zhang; Chenbo Zeng; Justin Rothfuss; Zhude Tu; Yunxiang Chu; David E Reichert; Michael J Welch; Robert H Mach
N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.
Journal of medicinal chemistry 2005;48(24):7637-47.
2005: Jinbin Xu; Zhude Tu; Lynne A Jones; Suwanna Vangveravong; Kenneth T Wheeler; Robert H Mach
[3H]N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methylbenzamide: a novel sigma-2 receptor probe.
European journal of pharmacology 2005;525(1-3):8-17.
2005: Zhude Tu; Wenhua Chu; Jun Zhang; Carmen S Dence; Michael J Welch; Robert H Mach
Synthesis and in vivo evaluation of [11C]PJ34, a potential radiotracer for imaging the role of PARP-1 in necrosis.
Nuclear medicine and biology 2005;32(5):437-43.
2005: Zhude Tu; Carmen S Dence; Datta E Ponde; Lynne Jones; Kenneth T Wheeler; Michael J Welch; Robert H Mach
Carbon-11 labeled sigma2 receptor ligands for imaging breast cancer.
Nuclear medicine and biology 2005;32(5):423-30.
2005: Wenhua Chu; Zhude Tu; Elizabeth McElveen; Jinbin Xu; Michelle Taylor; Robert R Luedtke; Robert H Mach
Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.
Bioorganic & medicinal chemistry 2005;13(1):77-87.
2004: Frederic H Fahey; H Donald Gage; Nancy Buchheimer; Holly C Smith; Beth A Harkness; Rodney C Williams; Michael C Bounds; Jennifer Mercier; Mike E Robbins; R Mark Payne; Kathryn A Morton; Robert H Mach
Evaluation of the quantitative capability of a high-resolution positron emission tomography scanner for small animal imaging.
Journal of computer assisted tomography 2004;28(6):842-8.
2004: Paige B Clark; H Donald Gage; Clive Brown-Proctor; Nancy Buchheimer; J Calles-Escandon; Robert H Mach; K A Morton
Neurofunctional imaging of the pancreas utilizing the cholinergic PET radioligand [18F]4-fluorobenzyltrozamicol.
European journal of nuclear medicine and molecular imaging 2004;31(2):258-60.
2004: Robert H Mach; Yunsheng Huang; Rebekah A Freeman; Li Wu; Suwanna Vangveravong; Robert R Luedtke
Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands.
Bioorganic & medicinal chemistry letters 2004;14(1):195-202.
2004: Carmen S Dence; Pilar Herrero; Sally W Schwarz; Robert H Mach; Robert J Gropler; Michael J Welch
Imaging myocardium enzymatic pathways with carbon-11 radiotracers.
Methods in enzymology 2004;385():286-315.
2003: Robert H Mach; Yunsheng Huang; Rebekah A Freeman; Li Wu; Suwanna Blair; Robert R Luedtke
Synthesis of 2-(5-bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues and their binding affinities for dopamine D2, D3, and D4 receptors.
Bioorganic & medicinal chemistry 2003;11(2):225-33.
2003: Robert R Luedtkea; Robert H Mach
Progress in developing D3 dopamine receptor ligands as potential therapeutic agents for neurological and neuropsychiatric disorders.
Current pharmaceutical design 2003;9(8):643-71.
2002: Michael A Nader; Rachna S Sinnott; Robert H Mach; Drake Morgan
Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist.
Psychopharmacology 2002;163(3-4):292-301.
2002: Drake Morgan; Kathleen A Grant; H Donald Gage; Robert H Mach; Jay R Kaplan; Osric Prioleau; Susan H Nader; Nancy Buchheimer; Richard L Ehrenkaufer; Michael A Nader
Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration.
Nature neuroscience 2002;5(2):169-74.
2001: Yunsheng Huang; PS Hammond; Li Wu; Robert H Mach
Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent sigma1 receptor ligands.
Journal of medicinal chemistry 2001;44(25):4404-15.
2001: Yunsheng Huang; Robert R Luedtke; Rebekah A Freeman; Li Wu; Robert H Mach
Synthesis of 2-(2,3-dimethoxyphenyl)-4-(aminomethyl)imidazole analogues and their binding affinities for dopamine D(2) and D(3) receptors.
Bioorganic & medicinal chemistry 2001;9(12):3113-22.
2001: Yunsheng Huang; Robert R Luedtke; Rebekah A Freeman; Li Wu; Robert H Mach
Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.
Journal of medicinal chemistry 2001;44(11):1815-26.
2001: Robert H Mach; Yunsheng Huang; Nancy Buchheimer; Ross Kuhner; Li Wu; Thomas E Morton; L Wang; Richard L Ehrenkaufer; CA Wallen; Kenneth T Wheeler
[[(18)F]N-(4'-fluorobenzyl)-4-(3-bromophenyl) acetamide for imaging the sigma receptor status of tumors: comparison with [(18)F]FDG, and [(125)I]IUDR.
Nuclear medicine and biology 2001;28(4):451-8.
2001: H Donald Gage; J C Gage; Joseph R Tobin; AI Chiari; Chuanyao Tong; Z Xu; Robert H Mach; S M N Efange; Richard L Ehrenkaufer; James Eisenach
Morphine-induced spinal cholinergic activation: in vivo imaging with positron emission tomography.
Pain 2001;91(1-2):139-45.
2001: Mary Lou Voytko; Robert H Mach; H Donald Gage; Richard L Ehrenkaufer; S M N Efange; Joseph R Tobin
Cholinergic activity of aged rhesus monkeys revealed by positron emission tomography.
Synapse (New York, N.Y.) 2001;39(1):95-100.
2000: Robert R Luedtke; Rebekah A Freeman; V A Boundy; Michael W Martin; Yunsheng Huang; Robert H Mach
Characterization of (125)I-IABN, a novel azabicyclononane benzamide selective for D2-like dopamine receptors.
Synapse (New York, N.Y.) 2000;38(4):438-49.
2000: H Donald Gage; Mary Lou Voytko; Richard L Ehrenkaufer; Joseph R Tobin; S M N Efange; Robert H Mach
Reproducibility of repeated measures of cholinergic terminal density using.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(12):2069-76.
2000: S M N Efange; AB Khare; Z Tu; Robert H Mach; SM Parsons
Synthesis and biological characterization of stable and radioiodinated (+/-)-trans-2-hydroxy-3-P[4-(3-iodophenyl)piperidyl]-1,2,3,4-tetrahydronaphthalene (3'-IBVM).
Nuclear medicine and biology 2000;27(8):749-55.
2000: Robert H Mach; Michael A Nader; Richard L Ehrenkaufer; H Donald Gage; Steven R Childers; L M Hodges; M M Hodges; Huw Davies
Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter.
Synapse (New York, N.Y.) 2000;37(2):109-17.
2000: Kenneth T Wheeler; L M Wang; CA Wallen; Steven R Childers; J Mark Cline; P C Keng; Robert H Mach
Sigma-2 receptors as a biomarker of proliferation in solid tumours.
British journal of cancer 2000;82(6):1223-32.
1999: Michael A Nader; KL Green; Robert R Luedtke; Robert H Mach
The effects of benzamide analogues on cocaine self-administration in rhesus monkeys.
Psychopharmacology 1999;147(2):143-52.
1999: I al-Nabulsi; Robert H Mach; L M Wang; CA Wallen; P C Keng; K Sten; Steven R Childers; Kenneth T Wheeler
Effect of ploidy, recruitment, environmental factors, and tamoxifen treatment on the expression of sigma-2 receptors in proliferating and quiescent tumour cells.
British journal of cancer 1999;81(6):925-33.
1999: Michael A Nader; Kathleen A Grant; H Donald Gage; Richard L Ehrenkaufer; Jay R Kaplan; Robert H Mach
PET imaging of dopamine D2 receptors with [18F]fluoroclebopride in monkeys: effects of isoflurane- and ketamine-induced anesthesia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;21(4):589-96.
1999: AB Khare; R B Langason; SM Parsons; Robert H Mach; S M N Efange
N-(3-Iodophenyl)trozamicol (IPHT) and related inhibitors of vesicular acetylcholine transport: synthesis and preliminary biological characterization.
Nuclear medicine and biology 1999;26(6):609-17.
1999: S M N Efange; AB Khare; Robert H Mach; SM Parsons
Hydroxylated decahydroquinolines as ligands for the vesicular acetylcholine transporter: synthesis and biological evaluation.
Journal of medicinal chemistry 1999;42(15):2862-9.
1999: Rachna S Sinnott; Robert H Mach; Michael A Nader
Dopamine D2/D3 receptors modulate cocaine's reinforcing and discriminative stimulus effects in rhesus monkeys.
Drug and alcohol dependence 1999;54(2):97-110.
1999: S M N Efange; Michael A Nader; Richard L Ehrenkaufer; AB Khare; CR Smith; Thomas E Morton; Robert H Mach
(+)-p-([18F]fluorobenzyl)spirotrozamicol [(+)-[18F]spiro-FBT]: synthesis and biological evaluation of a high-affinity ligand for the vesicular acetylcholine transporter (VAChT).
Nuclear medicine and biology 1999;26(2):189-92.
1999: Robert H Mach; Li Wu; T West; BR Whirrett; Steven R Childers
The analgesic tropane analogue (+/-)-SM 21 has a high affinity for sigma2 receptors.
Life sciences 1999;64(10):PL131-7.
1999: H Donald Gage; J C Gage; AI Chiari; Z M Xu; Robert H Mach; S M N Efange; Richard L Ehrenkaufer; James Eisenach
In vivo imaging of the spinal cord cholinergic system with PET.
Journal of computer assisted tomography 1999;23(1):25-33.
1998: Yunsheng Huang; PS Hammond; BR Whirrett; Ross Kuhner; Li Wu; Steven R Childers; Robert H Mach
Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptor ligands.
Journal of medicinal chemistry 1998;41(13):2361-70.
1998: Kathleen A Grant; Carol A Shively; Michael A Nader; Richard L Ehrenkaufer; SW Line; Thomas E Morton; H Donald Gage; Robert H Mach
Effect of social status on striatal dopamine D2 receptor binding characteristics in cynomolgus monkeys assessed with positron emission tomography.
Synapse (New York, N.Y.) 1998;29(1):80-3.
1997: S M N Efange; A P Kamath; AB Khare; M P Kung; Robert H Mach; SM Parsons
N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.
Journal of medicinal chemistry 1997;40(24):3905-14.
1997: Robert H Mach; Michael A Nader; Richard L Ehrenkaufer; SW Line; CR Smith; H Donald Gage; Thomas E Morton
Use of positron emission tomography to study the dynamics of psychostimulant-induced dopamine release.
Pharmacology, biochemistry, and behavior 1997;57(3):477-86.
1997: Robert H Mach; Mary Lou Voytko; Richard L Ehrenkaufer; Michael A Nader; Joseph R Tobin; S M N Efange; SM Parsons; H Donald Gage; CR Smith; Thomas E Morton
Imaging of cholinergic terminals using the radiotracer [18F](+)-4-fluorobenzyltrozamicol: in vitro binding studies and positron emission tomography studies in nonhuman primates.
Synapse (New York, N.Y.) 1997;25(4):368-80.
1997: Michael A Nader; Kathleen A Grant; Huw Davies; Robert H Mach; Steven R Childers
The reinforcing and discriminative stimulus effects of the novel cocaine analog 2beta-propanoyl-3beta-(4-tolyl)-tropane in rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 1997;280(2):541-50.
1997: Carol A Shively; Kathleen A Grant; Richard L Ehrenkaufer; Robert H Mach; Michael A Nader
Social stress, depression, and brain dopamine in female cynomolgus monkeys.
Annals of the New York Academy of Sciences 1997;807():574-7.
1997: Robert H Mach; CR Smith; I al-Nabulsi; BR Whirrett; Steven R Childers; Kenneth T Wheeler
Sigma 2 receptors as potential biomarkers of proliferation in breast cancer.
Cancer research 1997;57(1):156-61.
1996: Robert H Mach; Michael A Nader; Richard L Ehrenkaufer; SW Line; CR Smith; R R Luedtke; Mei-Ping Kung; Hank F Kung; David Lyons; Thomas E Morton
Comparison of two fluorine-18 labeled benzamide derivatives that bind reversibly to dopamine D2 receptors: in vitro binding studies and positron emission tomography.
Synapse (New York, N.Y.) 1996;24(4):322-33.
1996: Michael A Nader; Robert H Mach
Self-administration of the dopamine D3 agonist 7-OH-DPAT in rhesus monkeys is modified by prior cocaine exposure.
Psychopharmacology 1996;125(1):13-22.
1995: S M N Efange; Robert H Mach; CR Smith; AB Khare; C Foulon; S K Akella; S R Childers; SM Parsons
Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor.
Biochemical pharmacology 1995;49(6):791-7.
1995: Robert H Mach; Richard L Ehrenkaufer; Joel Greenberg; L Shao; Thomas E Morton; P H Evora; P A Nowak; R R Luedtke; D Cohen; Martin Reivich
PET imaging studies of dopamine D2 receptors: comparison of [18F]N-methylspiperone and the benzamide analogues [18F]MABN and [18F]MBP in baboon brain.
Synapse (New York, N.Y.) 1995;19(3):177-87.
1995: Robert H Mach; CR Smith; Steven R Childers
Ibogaine possesses a selective affinity for sigma 2 receptors.
Life sciences 1995;57(4):PL57-62.
1994: S M N Efange; Robert H Mach; AB Khare; R H Michelson; P A Nowak; P H Evora
p-[18F]fluorobenzyltrozamicol ([18F]FBT): molecular decomposition- reconstitution approach to vesamicol receptor radioligands for positron emission tomography.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1994;45(4):465-72.
1993: Robert H Mach; R R Luedtke; C D Unsworth; V A Boundy; P A Nowak; J G Scripko; S T Elder; J R Jackson; P L Hoffman; P H Evora
18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography.
Journal of medicinal chemistry 1993;36(23):3707-20.
1993: Robert H Mach; S T Elder; Thomas E Morton; P A Nowak; P H Evora; J G Scripko; R R Luedtke; C D Unsworth; T Filtz; A V Rao
The use of [18F]4-fluorobenzyl iodide (FBI) in PET radiotracer synthesis: model alkylation studies and its application in the design of dopamine D1 and D2 receptor-based imaging agents.
Nuclear medicine and biology 1993;20(6):777-94.
1993: Robert H Mach; P A Nowak; D A Moroney; Thomas E Morton; J R Jackson; Richard L Ehrenkaufer
Synthesis and in vivo evaluation of [18F]-N-(p-nitrobenzyl)spiperone ([18F]PNBS) in rats.
Nuclear medicine and biology 1993;20(3):269-78.
1993: S Chumpradit; Mei-Ping Kung; J Billings; Robert H Mach; Hank F Kung
Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.
Journal of medicinal chemistry 1993;36(2):221-8.
1992: R D Smith; Robert H Mach; Thomas E Morton; B S Dembowski; Richard L Ehrenkaufer
Optimization of [11C]CO2 trapping efficiencies from nitrogen gas streams.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1992;43(3):466-8.
1992: Robert H Mach; J R Jackson; R R Luedtke; K J Ivins; P B Molinoff; Richard L Ehrenkaufer
Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors.
Journal of medicinal chemistry 1992;35(3):423-30.
1991: Robert H Mach; Hank F Kung; P Jungwiwattanaporn; Y Z Guo
Synthesis and biodistribution of a new class of 99mTc-labeled fatty acid analogs for myocardial imaging.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(2):215-26.
1990: R R Luedtke; M Bush; Robert H Mach; R E Ehrenkaufer; Hank F Kung; P B Molinoff
Antibodies with high affinity for spiroperidol--II. Cross reactivity with iodobenzamide and domperidone.
Molecular immunology 1990;27(7):667-77.
1989: Robert H Mach; Hank F Kung; Y Z Guo; C C Yu; V Subramanyam; J C Calabrese
Synthesis, characterization and biodistribution of neutral and lipid-soluble 99mTc-PAT-HM and 99mTc-TMR for brain imaging.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1989;16(8):829-37.
1988: Hank F Kung; R Kasliwal; S G Pan; Mei-Ping Kung; Robert H Mach; Y Z Guo
Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide.
Journal of medicinal chemistry 1988;31(5):1039-43.
1988: Hank F Kung; J J Billings; Y Z Guo; Robert H Mach
Comparison of in vivo D-2 dopamine receptor binding of IBZM and NMSP in rat brain.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(2):203-8.
1988: Hank F Kung; Y Z Guo; J Billings; X Xu; Robert H Mach; M Blau; R E Ackerhalt
Preparation and biodistribution of [125I]IBZM: a potential CNS D-2 dopamine receptor imaging agent.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(2):195-201.