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Alberto Machado

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Sandro Argüelles; Mercedes Cano; Alberto Machado; Mario F Muñoz; Antonio Ayala
In vitro and in vivo protection by melatonin against the decline of elongation factor-2 caused by lipid peroxidation: preservation of protein synthesis.
Ma Carmen Hernández-Romero; Antonio J Herrera; Sandro Argüelles; Manuel J Bández; Josefina Cano; Rocío M de Pablos; M José Delgado-Cortés; Ana María Espinosa-Oliva; Raquel Mauriño; Marti Santiago; Manuel Sarmiento; José L Venero; Ruth F Villarán; Alberto Machado
Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system.
Alberto Machado; Antonio J Herrera; José L Venero; Marti Santiago; Rocío M de Pablos; R F Villarán; A M Espinosa-Oliva; Sandro Argüelles; M Sarmiento; M J Delgado-Cortés; R Mauriño; Josefina Cano
Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: possible implication in Parkinson's disease incidence.

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2012: Sandro Argüelles; Mercedes Cano; Alberto Machado; Mario F Muñoz; Antonio Ayala
In vitro and in vivo protection by melatonin against the decline of elongation factor-2 caused by lipid peroxidation: preservation of protein synthesis.
Journal of pineal research 2012;53(1):1-10.
2012: Ma Carmen Hernández-Romero; Antonio J Herrera; Sandro Argüelles; Manuel J Bández; Josefina Cano; Rocío M de Pablos; M José Delgado-Cortés; Ana María Espinosa-Oliva; Raquel Mauriño; Marti Santiago; Manuel Sarmiento; José L Venero; Ruth F Villarán; Alberto Machado
Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system.
Neurotoxicology 2012;33(3):347-60.
2011: Alberto Machado; Antonio J Herrera; José L Venero; Marti Santiago; Rocío M de Pablos; R F Villarán; A M Espinosa-Oliva; Sandro Argüelles; M Sarmiento; M J Delgado-Cortés; R Mauriño; Josefina Cano
Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: possible implication in Parkinson's disease incidence.
Parkinson's disease 2011;2011():393769.
2011: Sandro Argüelles; Mercedes Cano; Alberto Machado; Antonio Ayala
Effect of aging and oxidative stress on elongation factor-2 in hypothalamus and hypophysis.
Mechanisms of ageing and development 2011;132(1-2):55-64.
2011: M A Burguillos; N Hajji; E Englund; A Persson; A M Cenci; Alberto Machado; Josefina Cano; B Joseph; José L Venero
Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: evidence in Parkinson's disease patients.
Neurobiology of disease 2011;41(1):177-88.
2011: A M Espinosa-Oliva; Rocío M de Pablos; R F Villarán; Sandro Argüelles; José L Venero; Alberto Machado; Josefina Cano
Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus.
Neurobiology of aging 2011;32(1):85-102.
2010: José L Venero; Raquel Mauriño; Alberto Machado; Marti Santiago
Striatal ablation of GABAergic neurons prevents the in vivo neuroprotective effect of DCG-IV against the MPP+-induced neurotoxicity on dopaminergic nerve terminals.
Neurochemistry international 2010;57(8):979-84.
2010: Sandro Argüelles; José L Venero; S García-Rodriguez; M Tomas-Camardiel; Antonio Ayala; Josefina Cano; Alberto Machado
Use of haptoglobin and transthyretin as potential biomarkers for the preclinical diagnosis of Parkinson's disease.
Neurochemistry international 2010;57(3):227-34.
2010: Ruth F Villarán; Ana M Espinosa-Oliva; Manuel Sarmiento; Rocío M de Pablos; Sandro Argüelles; María J Delgado-Cortés; Verónica Sobrino; Nico van Rooijen; José L Venero; Antonio J Herrera; Josefina Cano; Alberto Machado
Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease.
Journal of neurochemistry 2010;114(6):1687-700.
2010: Raquel Mauriño; Alberto Machado; Marti Santiago
Effect of in vivo striatal perfusion of lipopolysaccharide on dopamine metabolites.
Neuroscience letters 2010;475(3):121-3.
2010: Sandro Argüelles; Antonio J Herrera; Eloisa Carreño-Müller; Rocío M de Pablos; Ruth F Villarán; Ana M Espinosa-Oliva; Alberto Machado; Josefina Cano
Degeneration of dopaminergic neurons induced by thrombin injection in the substantia nigra of the rat is enhanced by dexamethasone: role of monoamine oxidase enzyme.
Neurotoxicology 2010;31(1):55-66.
2009: Sandro Argüelles; Alberto Machado; Antonio Ayala
Adduct formation of 4-hydroxynonenal and malondialdehyde with elongation factor-2 in vitro and in vivo.
Free radical biology & medicine 2009;47(3):324-30.
2009: Ruth F Villarán; Rocío M de Pablos; Sandro Argüelles; Ana M Espinosa-Oliva; Mayka Tomás-Camardiel; Antonio J Herrera; Josefina Cano; Alberto Machado
The intranigral injection of tissue plasminogen activator induced blood-brain barrier disruption, inflammatory process and degeneration of the dopaminergic system of the rat.
Neurotoxicology 2009;30(3):403-13.
2009: Marti Santiago; Mari Carmen Hernández-Romero; Alberto Machado; Josefina Cano
Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not.
European journal of pharmacology 2009;609(1-3):58-64.
2008: J T García Navia; M A Burguillos; A Ramón-Cueto; Alberto Machado; Josefina Cano; José L Venero
Regional-specific regulation of BDNF and trkB correlates with nigral dopaminergic cell sprouting following unilateral nigrostriatal axotomy.
Journal of neuroscience research 2008;86(9):2016-27.
2008: Antonio J Herrera; Rocío M de Pablos; Eloisa Carreño-Müller; Ruth F Villarán; José L Venero; Mayka Tomás-Camardiel; Josefina Cano; Alberto Machado
The intrastriatal injection of thrombin in rat induced a retrograde apoptotic degeneration of nigral dopaminergic neurons through synaptic elimination.
Journal of neurochemistry 2008;105(3):750-62.
2008: María del Carmen Hernández-Romero; Sandro Argüelles; Ruth F Villarán; Rocío M de Pablos; María José Delgado-Cortés; Marti Santiago; Antonio J Herrera; Josefina Cano; Alberto Machado
Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide.
Journal of neurochemistry 2008;105(2):445-59.
2008: Ruth F Villarán; Mayka Tomás-Camardiel; Rocío M de Pablos; Marti Santiago; Antonio J Herrera; Ana Navarro; Alberto Machado; Josefina Cano
Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production.
Neurotoxicology 2008;29(2):244-58.
2008: Inmaculada Rite; Alberto Machado; Josefina Cano; José L Venero
Intracerebral VEGF injection highly upregulates AQP4 mRNA and protein in the perivascular space and glia limitans externa.
Neurochemistry international 2008;52(4-5):897-903.
2007: Inmaculada Rite; Sandro Argüelles; José L Venero; S García-Rodriguez; Antonio Ayala; Josefina Cano; Alberto Machado
Proteomic identification of biomarkers in the cerebrospinal fluid in a rat model of nigrostriatal dopaminergic degeneration.
Journal of neuroscience research 2007;85(16):3607-18.
2007: Inmaculada Rite; Alberto Machado; Josefina Cano; José L Venero
Blood-brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons.
Journal of neurochemistry 2007;101(6):1567-82.
2007: Sandro Argüelles; Alberto Machado; Antonio Ayala
'In vitro' protective effect of a hydrophilic vitamin E analogue on the decrease in levels of elongation factor 2 in conditions of oxidative stress.
Gerontology 2007;53(5):282-8.
2007: Antonio Ayala; José L Venero; Josefina Cano; Alberto Machado
Mitochondrial toxins and neurodegenerative diseases.
Frontiers in bioscience : a journal and virtual library 2007;12():986-1007.
2006: Marti Santiago; Esperanza R Matarredona; Alberto Machado; Josefina Cano
Acute perfusion of BMAA in the rat's striatum by in vivo microdialysis.
Toxicology letters 2006;167(1):34-9.
2006: Sandro Argüelles; Maria José Machado; Antonio Ayala; Alberto Machado; Blas Hervías
Correlation between circulating biomarkers of oxidative stress of maternal and umbilical cord blood at birth.
Free radical research 2006;40(6):565-70.
2006: Rocío M de Pablos; R F Villarán; Sandro Argüelles; Antonio J Herrera; José L Venero; Antonio Ayala; Josefina Cano; Alberto Machado
Stress increases vulnerability to inflammation in the rat prefrontal cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(21):5709-19.
2006: Sandro Argüelles; Alberto Machado; Antonio Ayala
"In vitro" effect of lipid peroxidation metabolites on elongation factor-2.
Biochimica et biophysica acta 2006;1760(3):445-52.
2005: Rocío M de Pablos; Antonio J Herrera; Mayka Tomás-Camardiel; Alberto Machado; Josefina Cano
Deprenyl enhances the striatal neuronal damage produced by quinolinic acid.
Brain research. Molecular brain research 2005;141(1):48-57.
2005: Mati Revuelta; Angélica Castaño; Alberto Machado; Josefina Cano; José L Venero
Kainate-induced zinc translocation from presynaptic terminals causes neuronal and astroglial cell death and mRNA loss of BDNF receptors in the hippocampal formation and amygdala.
Journal of neuroscience research 2005;82(2):184-95.
2005: Mayka Tomás-Camardiel; José L Venero; Antonio J Herrera; Rocío M de Pablos; José A Pintor-Toro; Alberto Machado; Josefina Cano
Blood-brain barrier disruption highly induces aquaporin-4 mRNA and protein in perivascular and parenchymal astrocytes: protective effect by estradiol treatment in ovariectomized animals.
Journal of neuroscience research 2005;80(2):235-46.
2005: Inmaculada Rite; Alberto Machado; Josefina Cano; José L Venero
Divergent regulatory mechanisms governing BDNF mRNA expression in cerebral cortex and substantia nigra in response to striatal target ablation.
Experimental neurology 2005;192(1):142-55.
2005: Rocío M de Pablos; Antonio J Herrera; Ruth F Villarán; Josefina Cano; Alberto Machado
Dopamine-dependent neurotoxicity of lipopolysaccharide in substantia nigra.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(3):407-9.
2005: Antonio J Herrera; Mayka Tomás-Camardiel; José L Venero; Josefina Cano; Alberto Machado
Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(1):111-9.
2004: Sandro Argüelles; Sonia García; Mariam Maldonado; Alberto Machado; Antonio Ayala
Do the serum oxidative stress biomarkers provide a reasonable index of the general oxidative stress status?
Biochimica et biophysica acta 2004;1674(3):251-9.
2004: Mayka Tomás-Camardiel; José L Venero; Rocío M de Pablos; Inmaculada Rite; Alberto Machado; Josefina Cano
In vivo expression of aquaporin-4 by reactive microglia.
Journal of neurochemistry 2004;91(4):891-9.
2004: Mayka Tomás-Camardiel; Inmaculada Rite; Antonio J Herrera; Rocío M de Pablos; Josefina Cano; Alberto Machado; José L Venero
Minocycline reduces the lipopolysaccharide-induced inflammatory reaction, peroxynitrite-mediated nitration of proteins, disruption of the blood-brain barrier, and damage in the nigral dopaminergic system.
Neurobiology of disease 2004;16(1):190-201.
2004: José L Venero; Alberto Machado; Josefina Cano
Importance of aquaporins in the physiopathology of brain edema.
Current pharmaceutical design 2004;10(18):2153-61.
2003: Juan Parrado; E H Absi; Alberto Machado; Antonio Ayala
"In vitro" effect of cumene hydroperoxide on hepatic elongation factor-2 and its protection by melatonin.
Biochimica et biophysica acta 2003;1624(1-3):139-44.
2003: Sonia Garcia-Rodriguez; Sandro Argüelles Castilla; Alberto Machado; Antonio Ayala
Comparison of methods for sample preparation of individual rat cerebrospinal fluid samples prior to two-dimensional polyacrylamide gel electrophoresis.
Biotechnology letters 2003;25(22):1899-903.
2003: Inmaculada Rite; José L Venero; Mayka Tomás-Camardiel; Alberto Machado; Josefina Cano
Expression of BDNF mRNA in substantia nigra is dependent on target integrity and independent of neuronal activation.
Journal of neurochemistry 2003;87(3):709-21.
2003: Marina Romero-Ramos; José L Venero; Sonia Garcia-Rodriguez; Antonio Ayala; Alberto Machado; Josefina Cano
Semichronic inhibition of glutathione reductase promotes oxidative damage to proteins and induces both transcription and translation of tyrosine hydroxylase in the nigrostriatal system.
Free radical research 2003;37(9):1003-12.
2003: S García-Rodríguez; Sandro Argüelles; R Llopis; Maria Luisa Murillo; Alberto Machado; Olimpia Carreras; Antonio Ayala
Effect of prenatal exposure to ethanol on hepatic elongation factor-2 and proteome in 21 d old rats: protective effect of folic acid.
Free radical biology & medicine 2003;35(4):428-37.
2003: Eloisa Carreño-Müller; Antonio J Herrera; Rocío M de Pablos; Mayka Tomás-Camardiel; José L Venero; Josefina Cano; Alberto Machado
Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia.
Journal of neurochemistry 2003;84(5):1201-14.
2003: José L Venero; Mati Revuelta; Leila Atiki; Marti Santiago; Mayka C Toms-Camardiel; Josefina Cano; Alberto Machado
Evidence for dopamine-derived hydroxyl radical formation in the nigrostriatal system in response to axotomy.
Free radical biology & medicine 2003;34(1):111-23.
2002: Elhadi Absi; Juan Parrado; Antonio Ayala; Alberto Machado
Decrease of 1-methyl-1,2,3,4-tetrahydroisoquinoline synthesizing enzyme activity in the brain areas of aged rat.
Brain research 2002;955(1-2):161-3.
2002: Mayka Tomás-Camardiel; Antonio J Herrera; José L Venero; Mari Cruz Sánchez-Hidalgo; Josefina Cano; Alberto Machado
Differential regulation of glutamic acid decarboxylase mRNA and tyrosine hydroxylase mRNA expression in the aged manganese-treated rats.
Brain research. Molecular brain research 2002;103(1-2):116-29.
2002: Angélica Castaño; Antonio J Herrera; Josefina Cano; Alberto Machado
The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma.
Journal of neurochemistry 2002;81(1):150-7.
2002: José L Venero; Marti Santiago; Mayka Tomás-Camardiel; Esperanza R Matarredona; Josefina Cano; Alberto Machado
DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury.
Neuroscience 2002;113(4):857-69.
2002: José L Venero; Elhadi Absi; Josefina Cano; Alberto Machado
Melatonin induces tyrosine hydroxylase mRNA expression in the ventral mesencephalon but not in the hypothalamus.
Journal of pineal research 2002;32(1):6-14.
2002: M Tomas-Camardiel; M C Sanchez-Hidalgo; M J Sanchez del Pino; A Navarro; Alberto Machado; Josefina Cano
Comparative study of the neuroprotective effect of dehydroepiandrosterone and 17beta-estradiol against 1-methyl-4-phenylpyridium toxicity on rat striatum.
Neuroscience 2002;109(3):569-84.
2001: Marisa Vizuete; José L Venero; vargas camila; Mati Revuelta; Alberto Machado; Josefina Cano
Potential role of endogenous brain-derived neurotrophic factor in long-term neuronal reorganization of the superior colliculus after bilateral visual deprivation.
Neurobiology of disease 2001;8(5):866-80.
2001: Marti Santiago; Alberto Machado; Josefina Cano
Validity of a quantitative technique to study striatal dopaminergic neurodegeneration by in vivo microdialysis.
Journal of neuroscience methods 2001;108(2):181-7.
2001: José L Venero; Marisa Vizuete; Alberto Machado; Josefina Cano
Aquaporins in the central nervous system.
Progress in neurobiology 2001;63(3):321-36.
2001: Mati Revuelta; Angélica Castaño; José L Venero; Alberto Machado; Josefina Cano
Long-lasting induction of brain-derived neurotrophic factor is restricted to resistant cell populations in an animal model of status epilepticus.
Neuroscience 2001;103(4):955-69.
2001: Esperanza R Matarredona; Marti Santiago; José L Venero; Josefina Cano; Alberto Machado
Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction.
Journal of neurochemistry 2001;76(2):351-60.
2000: Marina Romero-Ramos; José L Venero; Josefina Cano; Alberto Machado
Low selenium diet induces tyrosine hydroxylase enzyme in nigrostriatal system of the rat.
Brain research. Molecular brain research 2000;84(1-2):7-16.
2000: Antonio J Herrera; Angélica Castaño; José L Venero; Josefina Cano; Alberto Machado
The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system.
Neurobiology of disease 2000;7(4):429-47.
2000: Elhadi Absi; Antonio Ayala; Alberto Machado; Juan Parrado
Protective effect of melatonin against the 1-methyl-4-phenylpyridinium-induced inhibition of complex I of the mitochondrial respiratory chain.
Journal of pineal research 2000;29(1):40-7.
2000: Marisa Vizuete; M Merino; José L Venero; Marti Santiago; Josefina Cano; Alberto Machado
Histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra.
Journal of neurochemistry 2000;75(2):540-52.
2000: Juan Parrado; Elhadi Absi; Antonio Ayala; Angélica Castaño; Josefina Cano; Alberto Machado
The endogenous amine 1-methyl-1,2,3,4- tetrahydroisoquinoline prevents the inhibition of complex I of the respiratory chain produced by MPP(+).
Journal of neurochemistry 2000;75(1):65-71.
2000: Marti Santiago; Esperanza R Matarredona; L Granero; Josefina Cano; Alberto Machado
Neurotoxic relationship between dopamine and iron in the striatal dopaminergic nerve terminals.
Brain research 2000;858(1):26-32.
2000: Marina Romero-Ramos; José L Venero; Marti Santiago; J A Rodriguez-Gómez; Marisa Vizuete; Josefina Cano; Alberto Machado
Decreased messenger RNA expression of key markers of the nigrostriatal dopaminergic system following vitamin E deficiency in the rat.
Neuroscience 2000;101(4):1029-36.
2000: José L Venero; Marisa Vizuete; Mati Revuelta; vargas camila; Josefina Cano; Alberto Machado
Upregulation of BDNF mRNA and trkB mRNA in the nigrostriatal system and in the lesion site following unilateral transection of the medial forebrain bundle.
Experimental neurology 2000;161(1):38-48.
1999: Marisa Vizuete; José L Venero; vargas camila; Anunciación A Ilundáin; Miriam Echevarría; Alberto Machado; Josefina Cano
Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema.
Neurobiology of disease 1999;6(4):245-58.
1999: M Merino; Marisa Vizuete; Josefina Cano; Alberto Machado
The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+.
Journal of neurochemistry 1999;73(2):750-7.
1999: Juan Parrado; M Bougria; Antonio Ayala; Alberto Machado
Induced mono-(ADP)-ribosylation of rat liver cytosolic proteins by lipid peroxidant agents.
Free radical biology & medicine 1999;26(9-10):1079-84.
1999: Juan Parrado; M Bougria; Antonio Ayala; Angélica Castaño; Alberto Machado
Effects of aging on the various steps of protein synthesis: fragmentation of elongation factor 2.
Free radical biology & medicine 1999;26(3-4):362-70.
1999: José L Venero; Mati Revuelta; Alberto Machado; Josefina Cano
Delayed apoptotic pyramidal cell death in CA4 and CA1 hippocampal subfields after a single intraseptal injection of kainate.
Neuroscience 1999;94(4):1071-81.
1999: José L Venero; Marisa Vizuete; Anunciación A Ilundáin; Alberto Machado; M Echevarria; Josefina Cano
Detailed localization of aquaporin-4 messenger RNA in the CNS: preferential expression in periventricular organs.
Neuroscience 1999;94(1):239-50.
1999: Mati Revuelta; José L Venero; Alberto Machado; Josefina Cano
Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transection of the medial forebrain bundle. Correlation with reactive microglial and astroglial populations.
Neuroscience 1999;91(2):567-77.
1998: Marti Santiago; Esperanza R Matarredona; Alberto Machado; Josefina Cano
Influence of serotoninergic drugs on in vivo dopamine extracellular output in rat striatum.
Journal of neuroscience research 1998;52(5):591-8.
1998: Angélica Castaño; Antonio J Herrera; Josefina Cano; Alberto Machado
Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system.
Journal of neurochemistry 1998;70(4):1584-92.
1998: Antonio Ayala; Juan Parrado; Alberto Machado
Use of Rotofor preparative isoelectrofocusing cell in protein purification procedure.
Applied biochemistry and biotechnology 1998;69(1):11-6.
1997: Esperanza R Matarredona; Marti Santiago; Josefina Cano; Alberto Machado
Involvement of iron in MPP+ toxicity in substantia nigra: protection by desferrioxamine.
Brain research 1997;773(1-2):76-81.
1997: JA Rodríguez-Gómez; Marina Romero-Ramos; Marisa Vizuete; José L Venero; Josefina Cano; Alberto Machado
Increased activity and expression of tyrosine hydroxylase in the rat substantia nigra after chronic treatment with nomifensine.
Molecular pharmacology 1997;52(4):641-7.
1997: Mati Revuelta; José L Venero; Alberto Machado; Josefina Cano
Deprenyl induces GFAP immunoreactivity in the intact and injured dopaminergic nigrostriatal system but fails to counteract axotomy-induced degenerative changes.
Glia 1997;21(2):204-16.
1997: Marisa Vizuete; M Merino; Josefina Cano; Alberto Machado
In vivo protection of striatal dopaminergic system against 1-methyl-4-phenylpyridinium neurotoxicity by phenobarbital.
Journal of neuroscience research 1997;49(3):301-8.
1997: Esperanza R Matarredona; Marti Santiago; Alberto Machado; Josefina Cano
Lack of involvement of glutamate-induced excitotoxicity in MPP+ toxicity in striatal dopaminergic terminals: possible involvement of ascorbate.
British journal of pharmacology 1997;121(5):1038-44.
1997: JA Rodríguez-Gómez; José L Venero; Marisa Vizuete; Josefina Cano; Alberto Machado
Deprenyl induces the tyrosine hydroxylase enzyme in the rat dopaminergic nigrostriatal system.
Brain research. Molecular brain research 1997;46(1-2):31-8.
1997: José L Venero; Mati Revuelta; Josefina Cano; Alberto Machado
Time course changes in the dopaminergic nigrostriatal system following transection of the medial forebrain bundle: detection of oxidatively modified proteins in substantia nigra.
Journal of neurochemistry 1997;68(6):2458-68.
1997: Angélica Castaño; Antonio Ayala; JA Rodríguez-Gómez; Antonio J Herrera; Josefina Cano; Alberto Machado
Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat.
Neurochemistry international 1997;30(6):549-55.
1997: C P De la Cruz; Elisa Revilla; JA Rodríguez-Gómez; Marisa Vizuete; Josefina Cano; Alberto Machado
(-)-Deprenyl treatment restores serum insulin-like growth factor-I (IGF-I) levels in aged rats to young rat level.
European journal of pharmacology 1997;327(2-3):215-20.
1997: Marisa Vizuete; José L Venero; Elisabeth Traiffort; vargas camila; Alberto Machado; Josefina Cano
Expression of 5-HT7 receptor mRNA in rat brain during postnatal development.
Neuroscience letters 1997;227(1):53-6.
1997: José L Venero; Marisa Vizuete; Alberto Machado; Josefina Cano
Developmental expression of 5-HT7 receptor mRNA in rat brain visual structures after neonatal enucleation.
Neuroreport 1997;8(6):1531-5.
1997: Mati Revuelta; Marina Romero-Ramos; José L Venero; Francisco Millan; Alberto Machado; Josefina Cano
Less induced 1-methyl-4-phenylpyridinium ion neurotoxicity on striatal slices from guinea-pigs fed with a vitamin C-deficient diet.
Neuroscience 1997;77(1):167-74.
1997: Marti Santiago; Esperanza R Matarredona; L Granero; Josefina Cano; Alberto Machado
Neuroprotective effect of the iron chelator desferrioxamine against MPP+ toxicity on striatal dopaminergic terminals.
Journal of neurochemistry 1997;68(2):732-8.
1997: Marina Romero-Ramos; JA Rodríguez-Gómez; José L Venero; Josefina Cano; Alberto Machado
Chronic inhibition of the high-affinity dopamine uptake system increases oxidative damage to proteins in the aged rat substantia nigra.
Free radical biology & medicine 1997;23(1):1-7.
1996: José L Venero; Marti Santiago; Alberto Machado; Josefina Cano
MK-801 partially protects against the acute MPP+ depleting effect on dopamine levels in rat striatal slices.
Neurochemistry international 1996;29(4):411-6.
1996: Antonio Ayala; Juan Parrado; M Bougria; Alberto Machado
Effect of oxidative stress, produced by cumene hydroperoxide, on the various steps of protein synthesis. Modifications of elongation factor-2.
The Journal of biological chemistry 1996;271(38):23105-10.
1996: C P de la Cruz; E Revilla; V Steffen; JA Rodríguez-Gómez; Josefina Cano; Alberto Machado
Protection of the aged substantia nigra of the rat against oxidative damage by (-)-deprenyl.
British journal of pharmacology 1996;117(8):1756-60.
1996: M Santiago; Alberto Machado; Josefina Cano
Nigral and striatal comparative study of the neurotoxic action of 1-methyl-4-phenylpyridinium ion: involvement of dopamine uptake system.
Journal of neurochemistry 1996;66(3):1182-90.
1996: C P De La Cruz; E Revilla; José L Venero; Antonio Ayala; Josefina Cano; Alberto Machado
Oxidative inactivation of tyrosine hydroxylase in substantia nigra of aged rat.
Free radical biology & medicine 1996;20(1):53-61.
1995: Angélica Castaño; Antonio Ayala; J A Rodriguez-Gomez; C P de la Cruz; E Revilla; Josefina Cano; Alberto Machado
Increase in dopamine turnover and tyrosine hydroxylase enzyme in hippocampus of rats fed on low selenium diet.
Journal of neuroscience research 1995;42(5):684-91.
1995: E Alvarez; Manuel Conde; Alberto Machado; Francisco Sobrino; C Santa Maria
Decrease in free-radical production with age in rat peritoneal macrophages.
The Biochemical journal 1995;312 ( Pt 2)():555-60.
1995: M Bougria; Javier Vitorica; Josefina Cano; Alberto Machado
Implication of dopamine transporter system on 1-methyl-4-phenylpyridinium and rotenone effect in striatal synaptosomes.
European journal of pharmacology 1995;291(3):407-15.
1995: V Steffen; Marti Santiago; C P de la Cruz; E Revilla; Alberto Machado; Josefina Cano
Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine.
Human & experimental toxicology 1995;14(11):865-71.
1995: C S Maria; E Revilla; Antonio Ayala; C P de la Cruz; Alberto Machado
Changes in the histidine residues of Cu/Zn superoxide dismutase during aging.
FEBS letters 1995;374(1):85-8.
1995: Marti Santiago; Alberto Machado; Josefina Cano
5-HT3 receptor agonist induced carrier-mediated release of dopamine in rat striatum in vivo.
British journal of pharmacology 1995;116(1):1545-50.
1995: Marti Santiago; Luis Granero; Alberto Machado; Josefina Cano
Complex I inhibitor effect on the nigral and striatal release of dopamine in the presence and absence of nomifensine.
European journal of pharmacology 1995;280(3):251-6.
1995: José L Venero; Marina Romero-Ramos; Mati Revuelta; Alberto Machado; Josefina Cano
Intrastriatal quinolinic acid injections protect against 6-hydroxydopamine-induced lesions of the dopaminergic nigrostriatal system.
Brain research 1995;672(1-2):153-8.
1995: Diego Ruano; Jesus Benavides; Alberto Machado; Javier Vitorica
Aging-associated changes in the pharmacological properties of the benzodiazepine (omega) receptor isotypes in the rat hippocampus.
Journal of neurochemistry 1995;64(2):867-73.
1995: JA Rodríguez-Gómez; C de la Roza; Alberto Machado; Josefina Cano
The effect of age on the monoamines of the hypothalamus.
Mechanisms of ageing and development 1995;77(3):185-95.
1994: Diego Ruano; F Araujo; Alberto Machado; Angel L De Blas; Javier Vitorica
Molecular characterization of type I GABAA receptor complex from rat cerebral cortex and hippocampus.
Brain research. Molecular brain research 1994;25(3-4):225-33.
1994: Marisa Vizuete; V Steffen; Alberto Machado; Josefina Cano
1-Methyl-4-phenylpyridinium has greater neurotoxic effect after selenium deficiency than after vitamin E deficiency in rat striatum.
European journal of pharmacology 1994;270(2-3):183-7.
1994: Diego Ruano; Z Khan; Angel L De Blas; Alberto Machado; Javier Vitorica
Molecular heterogeneity of the type I GABAA/benzodiazepine receptor complex.
European journal of pharmacology 1994;267(1):123-8.
1994: Marti Santiago; Alberto Machado; Josefina Cano
Effect of L-arginine/nitric oxide pathway on MPP(+)-induced cell injury in the striatum of rats.
British journal of pharmacology 1994;111(3):837-42.
1994: Antonio Ayala; Juan Parrado; Josefina Cano; Alberto Machado
Reduction of 1-methyl 1,2,3,4-tetrahydroisoquinoline level in substantia nigra of the aged rat.
Brain research 1994;638(1-2):334-6.
1994: V Steffen; Marisa Vizuete; Alberto Machado; Josefina Cano
The effect of a vitamin E-deficient diet on amino acid levels in the substantia nigra, striatum and hippocampus of rats.
Life sciences 1994;54(5):375-9.
1993: José L Venero; C de la Roza; Alberto Machado; Josefina Cano
Age-related changes on monoamine turnover in hippocampus of rats.
Brain research 1993;631(1):89-96.
1993: José L Venero; Alberto Machado; Josefina Cano
Effect of ageing on monoamine turnover in the prefrontal cortex of rats.
Mechanisms of ageing and development 1993;72(2):105-18.
1993: Marti Santiago; Alberto Machado; Josefina Cano
Regulation of the prefrontal cortical dopamine release by GABAA and GABAB receptor agonists and antagonists.
Brain research 1993;630(1-2):28-31.
1993: E Alvarez; C Santa María; Alberto Machado
Respiratory burst reaction changes with age in rat peritoneal macrophages.
Biochimica et biophysica acta 1993;1179(3):247-52.
1993: Angélica Castaño; Josefina Cano; Alberto Machado
Low selenium diet affects monoamine turnover differentially in substantia nigra and striatum.
Journal of neurochemistry 1993;61(4):1302-7.
1993: E Alvarez; Valentina Ruiz-Gutiérrez; C Santa María; Alberto Machado
Age-dependent modification of lipid composition and lipid structural order parameter of rat peritoneal macrophage membranes.
Mechanisms of ageing and development 1993;71(1-2):1-12.
1993: Marisa Vizuete; C de la Roza; V Steffen; Alberto Machado; Josefina Cano
Changes in neurotransmitters in superior colliculus after neonatal enucleation: biochemical and immunocytochemical studies.
Neuroscience 1993;56(1):165-76.
1993: M Santiago; Alberto Machado; Josefina Cano
Regulation of prefrontal cortical dopamine release by dopamine receptor agonists and antagonists.
European journal of pharmacology 1993;239(1-3):83-91.
1993: M Santiago; Alberto Machado; Josefina Cano
In vivo release of dopamine from rat striatum, substantia nigra and prefrontal cortex: differential modulation by baclofen.
British journal of pharmacology 1993;109(3):814-8.
1993: Diego Ruano; Alberto Machado; Javier Vitorica
Absence of modifications of the pharmacological properties of the GABAA receptor complex during aging, as assessed in 3- and 24-month-old rat cerebral cortex.
European journal of pharmacology 1993;246(1):81-7.
1993: Antonio J Herrera; Alberto Machado; Josefina Cano
Ageing and monoamine turnover in the lateral geniculate nucleus and visual cortex of the rat.
Neurochemistry international 1993;22(6):531-9.
1993: Marisa Vizuete; V Steffen; A Ayala; Josefina Cano; Alberto Machado
Protective effect of deprenyl against 1-methyl-4-phenylpyridinium neurotoxicity in rat striatum.
Neuroscience letters 1993;152(1-2):113-6.
1993: Marti Santiago; Alberto Machado; Josefina Cano
Effects of age and dopamine agonists and antagonists on striatal dopamine release in the rat: an in vivo microdialysis study.
Mechanisms of ageing and development 1993;67(3):261-7.
1993: Angélica Castaño; Antonio J Herrera; Josefina Cano; Alberto Machado
Effects of a short period of vitamin E-deficient diet in the turnover of different neurotransmitters in substantia nigra and striatum of the rat.
Neuroscience 1993;53(1):179-85.
1993: Angélica Castaño; Marisa Vizuete; Josefina Cano; Alberto Machado
Turnover of monoamines in hippocampus of rats fed on vitamin E-deficient diet.
Brain research 1993;604(1-2):154-9.
1993: Diego Ruano; Jesus Benavides; Alberto Machado; Javier Vitorica
Regional differences in the enhancement by GABA of [3H]zolpidem binding to omega 1 sites in rat brain membranes and sections.
Brain research 1993;600(1):134-40.
1993: Juan Parrado; Antonio Ayala; Alberto Machado
Direct quantitative determination of peptides and proteins in PVDF transfer membrane using a computing densitometer.
Peptide research 1993;6(1):13-6.
1992: Marti Santiago; Alberto Machado; Josefina Cano
Fast sodium channel dependency of the somatodendritic release of dopamine in the rat's brain.
Neuroscience letters 1992;148(1-2):145-7.
1992: José L Venero; Antonio J Herrera; Alberto Machado; Josefina Cano
Changes in neurotransmitter levels associated with the deficiency of some essential amino acids in the diet.
The British journal of nutrition 1992;68(2):409-20.
1992: Marti Santiago; José L Venero; Alberto Machado; Josefina Cano
In vivo protection of striatum from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists.
Brain research 1992;586(2):203-7.
1992: Angélica Castaño; José L Venero; Josefina Cano; Alberto Machado
Changes in the turnover of monoamines in prefrontal cortex of rats fed on vitamin E-deficient diet.
Journal of neurochemistry 1992;58(5):1889-95.
1992: Marisa Vizuete; V Steffen; Alberto Machado; Josefina Cano
Effects of neonatal enucleation on catecholamine and serotonin turnover and amino acid levels in lateral geniculate nucleus and visual cortex of the adult rat.
Brain research 1992;575(2):231-7.
1992: Diego Ruano; Marisa Vizuete; Josefina Cano; Alberto Machado; Javier Vitorica
Heterogeneity in the allosteric interaction between the gamma-aminobutyric acid (GABA) binding site and three different benzodiazepine binding sites of the GABAA/benzodiazepine receptor complex in the rat nervous system.
Journal of neurochemistry 1992;58(2):485-93.
1991: José L Venero; Alberto Machado; Josefina Cano
Age effects on monoamine turnover of the rat substantia nigra.
Brain research 1991;557(1-2):109-14.
1991: Antonio J Herrera; Alberto Machado; Josefina Cano
The influence of age on neurotransmitter turnover in the rat's superior colliculus.
Neurobiology of aging 1991;12(4):289-94.
1991: E Gordillo; Alberto Machado
Implication of lysine residues in the loss of 6-phosphogluconate dehydrogenase activity in aging human erythrocytes.
Mechanisms of ageing and development 1991;59(3):291-7.
1991: Antonio Ayala; I Fabregat; Alberto Machado
The role of NADPH in the regulation of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in rat adipose tissue.
Molecular and cellular biochemistry 1991;105(1):1-5.
1991: Antonio Ayala; E Gordillo; Angélica Castaño; M F Lobato; Alberto Machado
Involvement of diminution of glutathione, produced by deficiency of methionine in the diet, in the elevation of malic enzyme level in rat liver.
Biochimica et biophysica acta 1991;1084(1):48-52.
1991: José L Venero; Alberto Machado; Josefina Cano
Turnover of dopamine and serotonin and their metabolites in the striatum of aged rats.
Journal of neurochemistry 1991;56(6):1940-8.
1991: V Steffen; E Gordillo; Angélica Castaño; Josefina Cano; Alberto Machado
Age-dependent changes in the activity and isoenzymatic pattern of the phosphofructokinase in different areas of the central nervous systems.
Neuroscience letters 1991;125(1):15-8.
1991: Alberto Machado; Antonio Ayala; E Gordillo; E Revilla; C Santa Maria
Relationship between enzymatic activity loss and post-translational protein modification in aging.
Archives of gerontology and geriatrics 1991;12(2-3):187-97.
1991: Diego Ruano; Josefina Cano; Alberto Machado; Javier Vitorica
Pharmacologic characterization of GABAA/benzodiazepine receptor in rat hippocampus during aging.
The Journal of pharmacology and experimental therapeutics 1991;256(3):902-8.
1991: Marisa Vizuete; Marti Santiago; Antonio J Herrera; José L Venero; Alberto Machado; Josefina Cano
Effects of neonatal bilateral eye enucleation on postnatal development of the monoamines in posterior thalamus of the rat.
Journal of neural transmission. General section 1991;85(3):231-42.
1990: Marisa Vizuete; Antonio J Herrera; Marti Santiago; Alberto Machado; Josefina Cano
Effects of enucleation on postnatal development of catecholamines and serotonin metabolism in the superior colliculus of the rat.
Brain research 1990;523(2):281-7.
1990: Antonio Ayala; I Fabregat; Alberto Machado
Possible involvement of NADPH requirement in regulation of glucose-6-phosphate and 6-phosphogluconate dehydrogenase levels in rat liver.
Molecular and cellular biochemistry 1990;95(2):107-15.
1990: Marisa Vizuete; Marti Santiago; Antonio J Herrera; Alberto Machado; Josefina Cano
Neonatal enucleation alters catecholamine and serotonin metabolism in the lateral geniculate and visual cortex in developing rats.
Neurochemistry international 1990;17(3):415-24.
1989: E Gordillo; Antonio Ayala; J Bautista; Alberto Machado
Implication of lysine residues in the loss of enzymatic activity in rat liver 6-phosphogluconate dehydrogenase found in aging.
The Journal of biological chemistry 1989;264(29):17024-8.
1989: J L Venero; Alberto Machado; J Cano
Changes in monoamines and their metabolite levels in substantia nigra of aged rats.
Mechanisms of ageing and development 1989;49(3):227-33.
1989: C Villanueva; I Fabregat; Alberto Machado
Inhibition of fatty acid biosynthesis by bezafibrate in different rat cells.
Biochemical pharmacology 1989;38(15):2505-10.
1989: José L Venero; Marti Santiago; Alberto Machado; Josefina Cano
Determination of monoamines and both forms of monoamine oxidase in the rat's substantia nigra during postnatal development.
Life sciences 1989;45(14):1277-83.
1989: M Santiago; Alberto Machado; Josefina Cano
Age-related changes of catecholamines and their metabolites content in the visual system of the rat.
Mechanisms of ageing and development 1989;47(1):77-84.
1988: C Santa Maria; Alberto Machado
Changes in some hepatic enzyme activities related to phase II drug metabolism in male and female rats as a function of age.
Mechanisms of ageing and development 1988;44(2):115-25.
1988: E Gordillo; Antonio Ayala; M F-Lobato; J Bautista; Alberto Machado
Possible involvement of histidine residues in the loss of enzymatic activity of rat liver malic enzyme during aging.
The Journal of biological chemistry 1988;263(17):8053-7.
1988: M Santiago; Alberto Machado; F Reinoso-Suárez; Josefina Cano
Changes in biogenic amines in rat hippocampus during development and aging.
Life sciences 1988;42(24):2503-8.
1987: I Fabregat; E Revilla; Alberto Machado
Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPH/NADP ratio in rat adipocytes and hepatocytes.
Biochemical and biophysical research communications 1987;146(2):920-5.
1987: E Revilla; I Fabregat; C Santa María; Alberto Machado
The NADPH-producing pathways (pentose phosphate and malic enzyme) are regulated by the NADPH consumption in rat mammary gland.
Biochemistry international 1987;14(5):957-62.
1987: M Santiago; Josefina Cano; F Reinoso-Suárez; Alberto Machado
Age-related changes of serotonin and its metabolites content in the visual system of the rat.
Mechanisms of ageing and development 1987;38(2):157-65.
1987: I Fabregat; E Revilla; Alberto Machado
The NADPH consumption regulates the NADPH-producing pathways (pentose phosphate cycle and malic enzyme) in rat adipocytes.
Molecular and cellular biochemistry 1987;74(1):77-81.