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Rajiv Machado

Research Profile

Chemicals & Drugs

Disorders

Physiology

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Procedures

DNA Mutational Analysis

Anatomy

Genes & Molecular Sequences

Dominant Genes

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Publications

TOP 3
Elaine Soon; Alan M Holmes; Carmen M Treacy; Natalie J Doughty; Laura Southgate; Rajiv D Machado; Richard C Trembath; Simon Jennings; Lucy Barker; Paul Nicklin; Christoph Walker; David C Budd; Joanna Pepke-Zaba; Nicholas W Morrell
Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension.
Micheala A Aldred; Rajiv D Machado; Victoria James; Nicholas W Morrell; Richard C Trembath
Characterization of the BMPR2 5'-untranslated region and a novel mutation in pulmonary hypertension.
Jay Suntharalingam; Rajiv D Machado; Linda D Sharples; Mark R Toshner; Karen K K Sheares; Rodney J Hughes; David P Jenkins; Richard C Trembath; Nicholas W Morrell; Joanna Pepke-Zaba
Demographic features, BMPR2 status and outcomes in distal chronic thromboembolic pulmonary hypertension.

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All Publications

2010: Elaine Soon; Alan M Holmes; Carmen M Treacy; Natalie J Doughty; Laura Southgate; Rajiv D Machado; Richard C Trembath; Simon Jennings; Lucy Barker; Paul Nicklin; Christoph Walker; David C Budd; Joanna Pepke-Zaba; Nicholas W Morrell
Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension.
Circulation 2010;122(9):920-7.
2007: Micheala A Aldred; Rajiv D Machado; Victoria James; Nicholas W Morrell; Richard C Trembath
Characterization of the BMPR2 5'-untranslated region and a novel mutation in pulmonary hypertension.
American journal of respiratory and critical care medicine 2007;176(8):819-24.
2007: Jay Suntharalingam; Rajiv D Machado; Linda D Sharples; Mark R Toshner; Karen K K Sheares; Rodney J Hughes; David P Jenkins; Richard C Trembath; Nicholas W Morrell; Joanna Pepke-Zaba
Demographic features, BMPR2 status and outcomes in distal chronic thromboembolic pulmonary hypertension.
Thorax 2007;62(7):617-22.
2006: Rajiv D Machado; Rolf Koehler; Eric Glissmeyer; Colin Veal; Jay Suntharalingam; Miryoung Kim; John F Carlquist; Margaret Town; C Gregory Elliott; Marius M Hoeper; Anna Fijalkowska; Marcin Kurzyna; Jennifer R Thomson; Simon R Gibbs; Martin R Wilkins; Werner Seeger; Nicholas W Morrell; Ekkehard Gruenig; Richard C Trembath; Bart Janssen
Genetic association of the serotonin transporter in pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2006;173(7):793-7.
2005: Rajiv D Machado; Victoria James; Mark Southwood; Rachel E Harrison; Carl Atkinson; Susan Stewart; Nicholas W Morrell; Richard C Trembath; Micheala A Aldred
Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension.
Circulation 2005;111(5):607-13.
2003: Rajiv D Machado; Nung Rudarakanchana; Carl Atkinson; Julia A Flanagan; Rachel Harrison; Nicholas W Morrell; Richard C Trembath
Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.
Human molecular genetics 2003;12(24):3277-86.
2003: Rachel E Harrison; Julia A Flanagan; M Sankelo; S A Abdalla; J Rowell; Rajiv D Machado; C Gregory Elliott; Ivan M Robbins; H Olschewski; Vallerie V McLaughlin; Ekkehard Gruenig; F Kermeen; Maija Halme; Anne Räisänen-Sokolowski; Tarja Laitinen; Nicholas W Morrell; Richard C Trembath
Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia.
Journal of medical genetics 2003;40(12):865-71.
2001: Richard C Trembath; Jennifer R Thomson; Rajiv D Machado; NV Morgan; Carl Atkinson; Ingrid Winship; Gérald Simonneau; Nazzareno Galie; James E Loyd; Marc Humbert; William C Nichols; Nicholas W Morrell; J Berg; Alessandra Manes; Julie McGaughran; Michael W Pauciulo; Lisa Wheeler
Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia.
The New England journal of medicine 2001;345(5):325-34.
2001: Rajiv D Machado; Michael W Pauciulo; Jennifer R Thomson; Kirk B Lane; NV Morgan; Lisa Wheeler; John A Phillips; J Newman; D Williams; Nazzareno Galiè; Alessandra Manes; K McNeil; M Yacoub; Ghada W Mikhail; P Rogers; Paul A Corris; Marc Humbert; D Donnai; G Martensson; L Tranebjaerg; James E Loyd; Richard C Trembath; William C Nichols
BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension.
American journal of human genetics 2001;68(1):92-102.
2000: Jennifer R Thomson; Rajiv D Machado; Michael W Pauciulo; NV Morgan; Marc Humbert; G C Elliott; K Ward; M Yacoub; Ghada W Mikhail; P Rogers; J Newman; Lisa Wheeler; T Higenbottam; J S Gibbs; J Egan; A Crozier; Andrew Peacock; R Allcock; Paul A Corris; James E Loyd; Richard C Trembath; William C Nichols
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family.
Journal of medical genetics 2000;37(10):741-5.
2000: K B Lane; Rajiv D Machado; Michael W Pauciulo; Jennifer R Thomson; John A Phillips; James E Loyd; William C Nichols; Richard C Trembath
Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension.
Nature genetics 2000;26(1):81-4.
2000: Rajiv D Machado; Michael W Pauciulo; N Fretwell; Colin Veal; Jennifer R Thomson; Carles vilarino-guell; Micheala A Aldred; C A Brannon; Richard C Trembath; William C Nichols
A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium.
Genomics 2000;68(2):220-8.