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Yoshiharu Machida

Research Profile

Chemicals & Drugs

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Chemistry, Pharmaceutical

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Microspheres

Disorders

Sarcoma 180

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Publications

TOP 3
Hiraku Onishi; Minoru Uchida; Yu Imura; Yoshiharu Machida
Enhancement potential of sucrose laurate (L-1695) on intestinal absorption of water-soluble high molecular weight compounds.
Hiraku Onishi; Hisashi Kikuchi; Yoshiharu Machida
Comparison of simple Eudragit microparticles loaded with prednisolone and Eudragit-coated chitosan-succinyl-prednisolone conjugate microparticles: Part I. Particle characteristics and in vitro evaluation as a colonic delivery system.
Osamu Sakata; Yoshiharu Machida; Hiraku Onishi
Semi-solid dosage form of clonazepam for rapid oral mucosal absorption.

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2012: Hiraku Onishi; Minoru Uchida; Yu Imura; Yoshiharu Machida
Enhancement potential of sucrose laurate (L-1695) on intestinal absorption of water-soluble high molecular weight compounds.
Current drug delivery 2012;9(5):487-94.
2012: Hiraku Onishi; Hisashi Kikuchi; Yoshiharu Machida
Comparison of simple Eudragit microparticles loaded with prednisolone and Eudragit-coated chitosan-succinyl-prednisolone conjugate microparticles: Part I. Particle characteristics and in vitro evaluation as a colonic delivery system.
Drug development and industrial pharmacy 2012;38(7):800-7.
2011: Osamu Sakata; Yoshiharu Machida; Hiraku Onishi
Semi-solid dosage form of clonazepam for rapid oral mucosal absorption.
Drug development and industrial pharmacy 2011;37(7):809-14.
2011: Hiraku Onishi; Yuta Saito; Masanaho Sasatsu; Yoshiharu Machida
Kinetic analysis of in vitro and in vivo release of prednisolone from the conjugate of glycol-chitosan and succinyl-prednisolone.
International journal of pharmaceutics 2011;410(1-2):17-22.
2010: Yayoi Kawano; Akihiko Ito; Masanaho Sasatsu; Yoshiharu Machida; Hiraku Onishi
[Preparation and evaluation of taste masked orally disintegrating tablets with granules made by the wet granulation method].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(12):1737-42.
2010: Takashi Masutomi; Hiraku Onishi; Yuri Takahashi; Yoshiharu Machida
Biodistribution study using Egg Protein ELISA kit after administration of FITC-labeled ovalbumin solution and its double liposomes in the in situ loop method, and its implication in oral immunization.
Current drug delivery 2010;7(5):447-52.
2010: Hiraku Onishi; Kennichi Koyama; Osamu Sakata; Yoshiharu Machida
Preparation of chitosan/alginate/calcium complex microparticles loaded with lactoferrin and their efficacy on carrageenan-induced edema in rats.
Drug development and industrial pharmacy 2010;36(8):879-84.
2010: Osamu Sakata; Hiraku Onishi; Yoshiharu Machida
[Development of semisolid dosage form of clonazepam for oral cavity administration].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(1):119-25.
2010: Yayoi Kawano; Akihiko Ito; Masanaho Sasatsu; Yoshiharu Machida
Preparation of orally disintegrating tablets with taste-masking function: masking effect in granules prepared with correctives using the dry granulation method and evaluation of tablets prepared using the taste-masked granules.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(1):81-6.
2010: Yayoi Kawano; Akihiko Ito; Masanaho Sasatsu; Yoshiharu Machida
[Preparation of orally disintegrating tablets for masking of unpleasant taste: comparison with corrective-adding methods].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(1):75-80.
2009: Kenta Yamamoto; Akihiko Ito; Yoshiharu Machida
Preparation and evaluation of medicinal carbon tablets with different saccharides as binders.
Chemical & pharmaceutical bulletin 2009;57(10):1058-60.
2009: Tadakazu Tokumura; Atsushi Muraoka; Yoshiharu Machida
Improvement of oral bioavailability of flurbiprofen from flurbiprofen/beta-cyclodextrin inclusion complex by action of cinnarizine.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2009;73(1):202-4.
2009: Takuma Koseki; Hiraku Onishi; Yuri Takahashi; Minoru Uchida; Yoshiharu Machida
Preparation and evaluation of novel directly-compressed fast-disintegrating furosemide tablets with sucrose stearic acid ester.
Biological & pharmaceutical bulletin 2009;32(6):1126-30.
2009: Keisuke Yamato; Yuri Takahashi; Hidero Akiyama; Kazuyuki Tsuji; Hiraku Onishi; Yoshiharu Machida
Effect of penetration enhancers on transdermal delivery of propofol.
Biological & pharmaceutical bulletin 2009;32(4):677-83.
2008: Osamu Sakata; Hiraku Onishi; Yoshiharu Machida
Clonazepam oral droplets for the treatment of acute epileptic seizures.
Drug development and industrial pharmacy 2008;34(12):1376-80.
2008: Takuma Koseki; Hiraku Onishi; Yuri Takahashi; Minoru Uchida; Yoshiharu Machida
Development of novel fast-disintegrating tablets by direct compression using sucrose stearic acid ester as a disintegration-accelerating agent.
Chemical & pharmaceutical bulletin 2008;56(10):1384-8.
2008: Masanaho Sasatsu; Hiraku Onishi; Yoshiharu Machida
Preparation and biodisposition of methoxypolyethylene glycol amine-poly(DL-lactic acid) copolymer nanoparticles loaded with pyrene-ended poly(DL-lactic acid).
International journal of pharmaceutics 2008;358(1-2):271-7.
2008: Hiraku Onishi; Tomoko Oosegi; Yoshiharu Machida
Efficacy and toxicity of Eudragit-coated chitosan-succinyl-prednisolone conjugate microspheres using rats with 2,4,6-trinitrobenzenesulfonic acid-induced colitis.
International journal of pharmaceutics 2008;358(1-2):296-302.
2008: Motonori Okuno; Yuri Takahashi; Koichi Isowa; Yoshiharu Machida
Effect of iontophoresis and switching iontophoresis on skin accumulation of ketoprofen.
Biological & pharmaceutical bulletin 2008;31(3):487-92.
2008: Tomoko Oosegi; Hiraku Onishi; Yoshiharu Machida
Gastrointestinal distribution and absorption behavior of Eudragit-coated chitosan-prednisolone conjugate microspheres in rats with TNBS-induced colitis.
International journal of pharmaceutics 2008;348(1-2):80-8.
2008: Tomoko Oosegi; Hiraku Onishi; Yoshiharu Machida
Novel preparation of enteric-coated chitosan-prednisolone conjugate microspheres and in vitro evaluation of their potential as a colonic delivery system.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(2):260-6.
2008: Hiraku Onishi; Yoshiharu Machida
In vitro and in vivo evaluation of microparticulate drug delivery systems composed of macromolecular prodrugs.
Molecules (Basel, Switzerland) 2008;13(9):2136-55.
2008: Ryotaro Kunii; Hiraku Onishi; Ken-ichi Ueki; Ken-ichi Koyama; Yoshiharu Machida
Particle characteristics and biodistribution of camptothecin-loaded PLA/(PEG-PPG-PEG) nanoparticles.
Drug delivery 2008;15(1):3-10.
2008: Atsushi Muraoka; Tadakazu Tokumura; Yoshiharu Machida
[In-vitro evaluation of cinnarizine as a competing agent to beta-cyclodextrin inclusion complexes: effect of cinnarizine on the membrane permeation rate of progesterone from its beta-cyclodextrin inclusion complex].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008;128(1):89-95.
2007: Kaori Hirose; Hiraku Onishi; Masanaho Sasatsu; Kazuo Takeshita; Kazuto Kouzuma; Koichi Isowa; Yoshiharu Machida
In vivo evaluation of Kumazasa extract and chitosan films containing the extract against deep skin ulcer model in rats.
Biological & pharmaceutical bulletin 2007;30(12):2406-11.
2007: Yuri Takahashi; C Takeda; I Seto; G Kawano; Yoshiharu Machida
Formulation and evaluation of lactoferrin bioadhesive tablets.
International journal of pharmaceutics 2007;343(1-2):220-7.
2007: Hiraku Onishi; Tomoko Oosegi; Yoshiharu Machida; James W McGinity
Eudragit coating of chitosan-prednisolone conjugate microspheres and in vitro evaluation of coated microspheres.
Drug development and industrial pharmacy 2007;33(8):848-54.
2007: Chikako Takeda; Yuri Takahashi; Isamu Seto; Genji Kawano; Kozo Takayama; Hiraku Onishi; Yoshiharu Machida
Influence of pectins on preparation characteristics of lactoferrin bioadhesive tablets.
Chemical & pharmaceutical bulletin 2007;55(8):1164-8.
2007: Ryotaro Kunii; Hiraku Onishi; Yoshiharu Machida
Preparation and antitumor characteristics of PLA/(PEG-PPG-PEG) nanoparticles loaded with camptothecin.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;67(1):9-17.
2007: Hiraku Onishi; Yoshiharu Machida; Kenichi Koyama
Preparation and in vitro characteristics of lactoferrin-loaded chitosan microparticles.
Drug development and industrial pharmacy 2007;33(6):641-7.
2007: Shuichi Aoyagi; Hiraku Onishi; Yoshiharu Machida
Novel chitosan wound dressing loaded with minocycline for the treatment of severe burn wounds.
International journal of pharmaceutics 2007;330(1-2):138-45.
2007: Kenta Yamamoto; Hiraku Onishi; Akihiko Ito; Yoshiharu Machida
In vitro and in vivo evaluation of medicinal carbon granules and tablet on the adsorption of acetaminophen.
International journal of pharmaceutics 2007;328(2):105-11.
2006: Masanaho Sasatsu; Hiraku Onishi; Yoshiharu Machida
In vitro and in vivo characterization of nanoparticles made of MeO-PEG amine/PLA block copolymer and PLA.
International journal of pharmaceutics 2006;317(2):167-74.
2006: Shinsuke Ogue; Yuri Takahashi; Hiraku Onishi; Yoshiharu Machida
Preparation of double liposomes and their efficiency as an oral vaccine carrier.
Biological & pharmaceutical bulletin 2006;29(6):1223-8.
2006: Akihiko Ito; Hiraku Onishi; Kenta Yamamoto; Yoshiharu Machida
Evaluation of binders in the preparation of medicinal carbon tablets by wet granule compression.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2006;126(4):315-9.
2006: Kenta Yamamoto; Hiraku Onishi; Akihiko Ito; Yoshiharu Machida
Medicinal carbon tablets for treatment of acetaminophen intoxication: adsorption characteristics of medicinal carbon powder and its tablets.
Chemical & pharmaceutical bulletin 2006;54(3):359-62.
2006: Tadakazu Tokumura; Yoshiharu Machida
Preparation of amoxicillin intragastric buoyant sustained-release tablets and the dissolution characteristics.
Journal of controlled release : official journal of the Controlled Release Society 2006;110(3):581-6.
2006: Hiraku Onishi; Yoshiharu Machida
[Nanoparticles prepared with PLA derivatives].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(2):225-30.
2005: H Sakurai; Yuri Takahashi; Yoshiharu Machida
Influence of low-frequency massage device on transdermal absorption of ionic materials.
International journal of pharmaceutics 2005;305(1-2):112-21.
2005: Hiraku Onishi; Mari Takahashi; Yoshiharu Machida
PLGA implant tablet of ketoprofen: comparison of in vitro and in vivo releases.
Biological & pharmaceutical bulletin 2005;28(10):2011-5.
2005: Hiraku Onishi; Yoshiharu Machida
Macromolecular and nanotechnological modification of camptothecin and its analogs to improve the efficacy.
Current drug discovery technologies 2005;2(3):169-83.
2005: Hiraku Onishi; Osamu Sakata; Kosuke Masuda; Yoshiharu Machida
Novel mucoadhesive oral patch containing diazepam.
Drug development and industrial pharmacy 2005;31(7):607-13.
2005: Hiraku Onishi; Tomoko Oosegi; Yoshiharu Machida; James W McGinity
Preparation and in vitro evaluation of chitosan microspheres containing prednisolone: comparison of simple and conjugate microspheres.
Drug development and industrial pharmacy 2005;31(7):597-605.
2005: Mika Hori; Hiraku Onishi; Yoshiharu Machida
Evaluation of Eudragit-coated chitosan microparticles as an oral immune delivery system.
International journal of pharmaceutics 2005;297(1-2):223-34.
2005: Tadakazu Tokumura; Atsushi Muraoka; Takashi Masutomi; Yoshiharu Machida
Stability of spironolactone in rat plasma: strict temperature control of blood and plasma samples is required in rat pharmacokinetic studies.
Biological & pharmaceutical bulletin 2005;28(6):1126-8.
2005: Yuri Takahashi; Keisuke Yamato; Hidero Akiyama; Kazuyuki Tsuji; Hiraku Onishi; Yoshiharu Machida
Transdermal absorption of propofol in rats.
Biological & pharmaceutical bulletin 2005;28(5):870-5.
2005: Masanaho Sasatsu; Hiraku Onishi; Yoshiharu Machida
Preparation of a PLA-PEG block copolymer using a PLA derivative with a formyl terminal group and its application to nanoparticulate formulation.
International journal of pharmaceutics 2005;294(1-2):233-45.
2004: Mari Takahashi; Hiraku Onishi; Yoshiharu Machida
Development of implant tablet for a week-long sustained release.
Journal of controlled release : official journal of the Controlled Release Society 2004;100(1):63-74.
2004: Atsushi Muraoka; Tadakazu Tokumura; Yoshiharu Machida
Evaluation of the bioavailability of flurbiprofen and its beta-cyclodextrin inclusion complex in four different doses upon oral administration to rats.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2004;58(3):667-71.
2004: Nobuyuki Ishiki; Hiraku Onishi; Yoshiharu Machida
Evaluation of antitumor and toxic side effects of mitomycin C-estradiol conjugates.
International journal of pharmaceutics 2004;279(1-2):81-93.
2004: Hiroyuki Suzuki; Hiraku Onishi; Seiji Hisamatsu; Kosuke Masuda; Yuri Takahashi; Masanori Iwata; Yoshiharu Machida
Acetaminophen-containing chewable tablets with suppressed bitterness and improved oral feeling.
International journal of pharmaceutics 2004;278(1):51-61.
2004: Hidetaka Miura; Hiraku Onishi; Masanaho Sasatsu; Yoshiharu Machida
Antitumor characteristics of methoxypolyethylene glycol-poly(DL-lactic acid) nanoparticles containing camptothecin.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(1):101-13.
2004: Hiroaki Takahashi; Hiraku Onishi; Yoshiharu Machida
Glycyrrhetic acid-loaded microparticles: liver-specific delivery and therapeutic potential against carbon tetrachloride-induced hepatitis.
The Journal of pharmacy and pharmacology 2004;56(4):437-44.
2004: Yoshinori Kato; Hiraku Onishi; Yoshiharu Machida
N-succinyl-chitosan as a drug carrier: water-insoluble and water-soluble conjugates.
Biomaterials 2004;25(5):907-15.
2003: Yoshinori Kato; Hiraku Onishi; Yoshiharu Machida
Application of chitin and chitosan derivatives in the pharmaceutical field.
Current pharmaceutical biotechnology 2003;4(5):303-9.
2003: Ken Katayama; Yoshinori Kato; Hiraku Onishi; Tsuneji Nagai; Yoshiharu Machida
Double liposomes: hypoglycemic effects of liposomal insulin on normal rats.
Drug development and industrial pharmacy 2003;29(7):725-31.
2003: Kenji Yamabe; Yoshinori Kato; Hiraku Onishi; Yoshiharu Machida
In vitro characteristics of liposomes and double liposomes prepared using a novel glass beads method.
Journal of controlled release : official journal of the Controlled Release Society 2003;90(1):71-9.
2003: Kenji Yamabe; Yoshinori Kato; Hiraku Onishi; Yoshiharu Machida
Potentiality of double liposomes containing salmon calcitonin as an oral dosage form.
Journal of controlled release : official journal of the Controlled Release Society 2003;89(3):429-36.
2003: Tomoaki Yoshino; Yoshiharu Machida; Hiraku Onishi; Tsuneji Nagai
Preparation and characterization of chitosan microspheres containing doxifluridine.
Drug development and industrial pharmacy 2003;29(4):417-27.
2003: Hiroyuki Suzuki; Hiraku Onishi; Yuri Takahashi; Masanori Iwata; Yoshiharu Machida
Development of oral acetaminophen chewable tablets with inhibited bitter taste.
International journal of pharmaceutics 2003;251(1-2):123-32.
2003: Hiraku Onishi; Yoshiharu Machida; Yoshiharu Machida
Antitumor properties of irinotecan-containing nanoparticles prepared using poly(DL-lactic acid) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol).
Biological & pharmaceutical bulletin 2003;26(1):116-9.
2002: Osamu Ishikawa; Yoshinori Kato; Hiraku Onishi; Tsuneji Nagai; Yoshiharu Machida
Enhancement of transdermal absorption by switching iontophoresis.
International journal of pharmaceutics 2002;249(1-2):81-8.
2002: Ken Katayama; Yoshinori Kato; Hiraku Onishi; Tsuneji Nagai; Yoshiharu Machida
Preparation of novel double liposomes using the glass-filter method.
International journal of pharmaceutics 2002;248(1-2):93-9.
2002: Junko Takishima; Hiraku Onishi; Yoshiharu Machida
Prolonged intestinal absorption of cephradine with chitosan-coated ethylcellulose microparticles in rats.
Biological & pharmaceutical bulletin 2002;25(11):1498-502.
2002: Nobuyuki Ishiki; Hiraku Onishi; Yoshiharu Machida
Antitumor activities of conjugates of mitomycin C with estradiol benzoate and estradiol via glutaric acid in suspension dosage form.
Biological & pharmaceutical bulletin 2002;25(10):1373-7.
2002: Yoshinori Kato; Hiraku Onishi; Yoshiharu Machida
Tumour cell uptake of lactosaminated and intact N-succinyl-chitosans and antitumour effects of conjugates with mitomycin C.
Anticancer research 2002;22(5):2771-6.
2002: Yoshinori Kato; Hiraku Onishi; Yoshiharu Machida
Efficacy of lactosaminated and intact N-succinylchitosan-mitomycin C conjugates against M5076 liver metastatic cancer.
The Journal of pharmacy and pharmacology 2002;54(4):529-37.
2002: Yoshinori Kato; Hiraku Onishi; Yoshiharu Machida
Depolymerization of N-succinyl-chitosan by hydrochloric acid.
Carbohydrate research 2002;337(6):561-4.
2001: Tadakazu Tokumura; Yoshiharu Machida
UV absorption method should not be applied for determining amoxycillin in acidic dissolution test medium.
International journal of pharmaceutics 2001;228(1-2):1-4.
2001: Yoshinori Kato; Hiraku Onishi; Yoshiharu Machida
Lactosaminated and intact N-succinyl-chitosans as drug carriers in liver metastasis.
International journal of pharmaceutics 2001;226(1-2):93-106.
2001: T Yamada; Hiraku Onishi; Yoshiharu Machida
Sustained release ketoprofen microparticles with ethylcellulose and carboxymethylethylcellulose.
Journal of controlled release : official journal of the Controlled Release Society 2001;75(3):271-82.
2001: Hiraku Onishi; H Takahashi; M Yoshiyasu; Yoshiharu Machida
Preparation and in vitro properties of N-succinylchitosan- or carboxymethylchitin-mitomycin C conjugate microparticles with specified size.
Drug development and industrial pharmacy 2001;27(7):659-67.
2001: J Shimoda; Hiraku Onishi; Yoshiharu Machida
Bioadhesive characteristics of chitosan microspheres to the mucosa of rat small intestine.
Drug development and industrial pharmacy 2001;27(6):567-76.
2001: Yoshinori Kato; Hiraku Onishi; Yoshiharu Machida
Biological characteristics of lactosaminated N-succinyl-chitosan as a liver-specific drug carrier in mice.
Journal of controlled release : official journal of the Controlled Release Society 2001;70(3):295-307.
2000: Yoshinori Kato; Hiraku Onishi; Yoshiharu Machida
Biological fate of highly-succinylated N-succinyl-chitosan and antitumor characteristics of its water-soluble conjugate with mitomycin C at i.v. and i.p. administration into tumor-bearing mice.
Biological & pharmaceutical bulletin 2000;23(12):1497-503.
2000: H Hata; Hiraku Onishi; Yoshiharu Machida
Preparation of CM-chitin microspheres by complexation with iron(III) in w/o emulsion and their biodisposition characteristics in mice.
Biomaterials 2000;21(17):1779-88.
2000: Yoshinori Kato; Hiraku Onishi; Yoshiharu Machida
Evaluation of N-succinyl-chitosan as a systemic long-circulating polymer.
Biomaterials 2000;21(15):1579-85.
2000: R Yahagi; Yoshiharu Machida; Hiraku Onishi
Mucoadhesive suppositories of ramosetron hydrochloride utilizing Carbopol.
International journal of pharmaceutics 2000;193(2):205-12.
1999: R Yahagi; Hiraku Onishi; Yoshiharu Machida
Preparation and evaluation of double-phased mucoadhesive suppositories of lidocaine utilizing Carbopol and white beeswax.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(1-2):1-8.
1999: K Kamiyama; Hiraku Onishi; Yoshiharu Machida
Biodisposition characteristics of N-succinyl-chitosan and glycol-chitosan in normal and tumor-bearing mice.
Biological & pharmaceutical bulletin 1999;22(2):179-86.
1999: Hiraku Onishi; Yoshiharu Machida
Biodegradation and distribution of water-soluble chitosan in mice.
Biomaterials 1999;20(2):175-82.
1998: Nobuyuki Ishiki; Hiraku Onishi; Yoshiharu Machida
In vivo properties of the conjugates of mitomycin C with estradiol benzoate and estradiol: pharmacokinetics and antitumor characteristics against P388 leukemia and sarcoma 180.
Biological & pharmaceutical bulletin 1998;21(11):1180-6.
1997: Nobuyuki Ishiki; Hiraku Onishi; Yoshiharu Machida
Biological properties of conjugates of mitomycin C with estradiol benzoate and estradiol: their stability characteristics in biological media and their binding abilities to estrogen receptor.
Biological & pharmaceutical bulletin 1997;20(10):1096-102.
1996: M Sato; Hiraku Onishi; J Takahara; Yoshiharu Machida; Tsuneji Nagai
In vivo drug release and antitumor characteristics of water-soluble conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan.
Biological & pharmaceutical bulletin 1996;19(9):1170-7.
1996: M Sato; Hiraku Onishi; M Kitano; Yoshiharu Machida; Tsuneji Nagai
Preparation and drug release characteristics of the conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan.
Biological & pharmaceutical bulletin 1996;19(2):241-5.
1993: Y Obata; Kozo Takayama; Yoshie Maitani; Yoshiharu Machida; Tsuneji Nagai
Effect of pretreatment of skin with cyclic monoterpenes on permeation of diclofenac in hairless rat.
Biological & pharmaceutical bulletin 1993;16(3):312-4.
1993: H Ichikawa; Hiraku Onishi; T Takahata; Yoshiharu Machida; Tsuneji Nagai
Evaluation of the conjugate between N4-(4-carboxybutyryl)-1-beta-D-arabinofuranosylcytosine and chitosan as a macromolecular prodrug of 1-beta-D-arabinofuranosylcytosine.
Drug design and discovery 1993;10(4):343-53.
1993: M Morishita; I Morishita; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin.
Biological & pharmaceutical bulletin 1993;16(1):68-72.
1991: Y Obata; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Combined effect of cyclic monoterpenes and ethanol on percutaneous absorption of diclofenac sodium.
Drug design and discovery 1991;8(2):137-44.
1990: Kozo Takayama; M Hirata; Yoshiharu Machida; T Masada; T Sannan; Tsuneji Nagai
Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablet consisting of chitosan and sodium hyaluronate.
Chemical & pharmaceutical bulletin 1990;38(7):1993-7.
1990: T Igawa; Yoshie Maitani; Yoshiharu Machida; Tsuneji Nagai
Intranasal administration of human fibroblast interferon in mice, rats, rabbits and dogs.
Chemical & pharmaceutical bulletin 1990;38(2):549-51.
1989: Yoshiharu Machida; K Inouye; T Tokumura; M Iwata; Tsuneji Nagai
Preparation and evaluation of intragastric buoyant preparations.
Drug design and delivery 1989;4(2):155-61.
1989: Yoshie Maitani; T Igawa; Yoshiharu Machida; Tsuneji Nagai
Plasma levels following intranasal and intravenous administration of human interferon-beta to rabbits.
Drug design and delivery 1989;4(2):109-19.
1989: T Igawa; Yoshie Maitani; Yoshiharu Machida; Tsuneji Nagai
Effect of absorption promoters in intranasal administration of human fibroblast interferon as a powder dosage form in rabbits.
Chemical & pharmaceutical bulletin 1989;37(2):418-21.
1989: K Inouye; Yoshiharu Machida; T Sannan; Tsuneji Nagai
Buoyant sustained release granules based on chitosan.
Drug design and delivery 1989;4(1):55-67.
1988: T Igawa; Yoshie Maitani; Yoshiharu Machida; Tsuneji Nagai
Enzyme immunoassay of human fibroblast interferon after intranasal administration with several excipients in rabbits.
Chemical & pharmaceutical bulletin 1988;36(8):3055-9.
1988: Y Akasaka; Haruhisa Ueda; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Preparation and evaluation of bovine serum albumin nanospheres coated with monoclonal antibodies.
Drug design and delivery 1988;3(1):85-97.
1988: Y Akitoshi; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Effect of cyclohexanone derivatives on percutaneous absorption of ketoprofen and indomethacin.
Drug design and delivery 1988;2(3):239-45.
1988: K Inouye; Yoshiharu Machida; T Sannan; Tsuneji Nagai
Buoyant sustained release tablets based on chitosan.
Drug design and delivery 1988;2(3):165-75.
1987: Y Nakagawa; Kozo Takayama; Haruhisa Ueda; Yoshiharu Machida; Tsuneji Nagai
Preparation of bovine serum albumin nanospheres as drug targeting carriers.
Drug design and delivery 1987;2(2):99-107.
1987: K Arai; Kozo Takayama; Y Nambu; N Nambu; Haruhisa Ueda; Yoshiharu Machida; Tsuneji Nagai
Preparation of polylactic acid-polylipoic acid nanospheres as drug targeting carriers.
Drug design and delivery 1987;2(2):109-20.
1987: J Szeman; Haruhisa Ueda; J Szejtli; E Fenyvesi; Y Watanabe; Yoshiharu Machida; Tsuneji Nagai
Enhanced percutaneous absorption of homogenized tolnaftate/beta-cyclodextrin polymer ground mixture.
Drug design and delivery 1987;1(4):325-32.
1987: K Inouye; Yoshiharu Machida; Tsuneji Nagai
Sustained release tablets based on chitosan and carboxymethylcellulose sodium.
Drug design and delivery 1987;1(4):297-305.
1987: T Ishikura; Tsuneji Nagai; Y Sakai; T Shishikura; H Ebisawa; Yoshiharu Machida
Enhanced percutaneous absorption of ionizable water-soluble drugs.
Drug design and delivery 1987;1(4):285-95.
1987: T Sekine; Yoshiharu Machida; Tsuneji Nagai
Gel ointment of verapamil for percutaneous absorption.
Drug design and delivery 1987;1(3):245-52.
1987: Yoshiharu Machida; T Tokumura; Tsuneji Nagai
Per-oral controlled release dosage form of theophylline using soybean protein.
Drug design and delivery 1987;1(3):187-92.
1987: Yoshiharu Machida; T Tokumura; Tsuneji Nagai
Use of soybean protein for controlled release of drugs administered orally.
Drug design and delivery 1987;1(3):179-86.
1987: M Iwata; Yoshiharu Machida; Tsuneji Nagai; H Masuda
Double-layered stick-type formulation of bleomycin for treatment of uterine cervical cancer.
Drug design and delivery 1987;1(3):253-60.
1987: J Szeman; Haruhisa Ueda; J Szejtli; E Fenyvesi; Yoshiharu Machida; Tsuneji Nagai
Complexation of several drugs with water-soluble cyclodextrin polymer.
Chemical & pharmaceutical bulletin 1987;35(1):282-8.
1986: T Ishikura; Tsuneji Nagai; Y Sakai; T Shishikura; H Ebisawa; Yoshiharu Machida
Comparison of the metabolism of diltiazem following percutaneous, subcutaneous, oral and intravenous administration.
Drug design and delivery 1986;1(2):151-6.
1986: Yoshiharu Machida; Tsuneji Nagai; M Abe; T Sannan
Use of chitosan and hydroxypropylchitosan in drug formulations to effect sustained release.
Drug design and delivery 1986;1(2):119-30.
1986: Yoshie Maitani; T Igawa; Yoshiharu Machida; Tsuneji Nagai
Intranasal administration of beta-interferon in rabbits.
Drug design and delivery 1986;1(1):65-70.