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Fabienne Mackay

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Xue Q Liu; Fabienne Mackay; David Narum; Susan K Pierce; Katryn J Stacey; Jasmyn A Cridland; Katja Fischer; Joshua M Horne-Debets; Michelle Wykes
Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival.
Laurence Macia; Fabienne Mackay; Priya T Rao; Frederic Sierro; Julie Wheway; Herbert Herzog
Y1 signalling has a critical role in allergic airway inflammation.
Claudia Bossen; Aubry Tardivel; Laure Willen; Carrie A Fletcher; M Perroud; Friedrich Beermann; Antonius G Rolink; Martin L Scott; Fabienne Mackay; Pascal Schneider
Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.

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2012: Xue Q Liu; Fabienne Mackay; David Narum; Susan K Pierce; Katryn J Stacey; Jasmyn A Cridland; Katja Fischer; Joshua M Horne-Debets; Michelle Wykes
Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival.
European journal of immunology 2012;42(12):3291-301.
2011: Laurence Macia; Fabienne Mackay; Priya T Rao; Frederic Sierro; Julie Wheway; Herbert Herzog
Y1 signalling has a critical role in allergic airway inflammation.
Immunology and cell biology 2011;89(8):882-8.
2011: Claudia Bossen; Aubry Tardivel; Laure Willen; Carrie A Fletcher; M Perroud; Friedrich Beermann; Antonius G Rolink; Martin L Scott; Fabienne Mackay; Pascal Schneider
Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.
European journal of immunology 2011;41(3):787-97.
2008: Fabienne Mackay; Pascal Schneider
TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties.
Cytokine & growth factor reviews 2008;19(3-4):263-76.
2008: eliana marino; Marcel Batten; Joanna Groom; Stacey Walters; David Liuwantara; Fabienne Mackay; Shane T Grey
Marginal-zone B-cells of nonobese diabetic mice expand with diabetes onset, invade the pancreatic lymph nodes, and present autoantigen to diabetogenic T-cells.
Diabetes 2008;57(2):395-404.
2008: Claudia Bossen; Teresa G Cachero; Aubry Tardivel; Karine Ingold; Laure Willen; Max Dobles; Martin L Scott; Aris Maquelin; Elodie Belnoue; Claire-Anne Siegrist; Stéphane Chevrier; Hans Acha-Orbea; Helen Leung; Fabienne Mackay; Jürg Tschopp; Pascal Schneider
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.
Blood 2008;111(3):1004-12.
2008: Joanna Groom; Fabienne Mackay
B cells flying solo.
Immunology and cell biology 2008;86(1):40-6.
2007: Frederic Sierro; Christine Biben; Laura Martínez-Muñoz; Mario Mellado; Richard M Ransohoff; Meizhang Li; Blanche Woehl; Helen Leung; Joanna Groom; Marcel Batten; Richard P Harvey; Carlos Martínez-A; Charles R Mackay; Fabienne Mackay
Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(37):14759-64.
2007: Fabienne Mackay; Joanna Groom; Stuart G Tangye
An important role for B-cell activation factor and B cells in the pathogenesis of Sjögren's syndrome.
Current opinion in rheumatology 2007;19(5):406-13.
2007: Joanna Groom; Carrie A Fletcher; Stacey N Walters; Shane T Grey; Sally V Watt; Mathew J Sweet; Mark J Smyth; Charles R Mackay; Fabienne Mackay
BAFF and MyD88 signals promote a lupuslike disease independent of T cells.
The Journal of experimental medicine 2007;204(8):1959-71.
2007: Fabienne Mackay; Pablo Alejandro Silveira; Robert Brink
B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling.
Current opinion in immunology 2007;19(3):327-36.
2007: Julie Wheway; Herbert Herzog; Fabienne Mackay
The Y1 receptor for NPY: a key modulator of the adaptive immune system.
Peptides 2007;28(2):453-8.
2007: Julie Wheway; Herbert Herzog; Fabienne Mackay
NPY and receptors in immune and inflammatory diseases.
Current topics in medicinal chemistry 2007;7(17):1743-52.
2007: Alexander Viardot; Shane T Grey; Fabienne Mackay; Donald Chisholm
Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype.
Endocrinology 2007;148(1):346-53.
2006: Andrew Sutherland; Fabienne Mackay; Charles R Mackay
Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas.
Pharmacology & therapeutics 2006;112(3):774-86.
2006: Carrie A Fletcher; Andrew Sutherland; Joanna Groom; Marcel Batten; Lai Guan Ng; Jennifer L Gommerman; Fabienne Mackay
Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells.
European journal of immunology 2006;36(9):2504-14.
2006: Lai Guan Ng; Chee-Hoe Ng; Blanche Woehl; Andrew Sutherland; Jianxin Huo; Shengli Xu; Fabienne Mackay; Kong-Peng Lam
BAFF costimulation of Toll-like receptor-activated B-1 cells.
European journal of immunology 2006;36(7):1837-46.
2006: Kate L Jeffrey; Tilman Brummer; Michael S Rolph; Sue M Liu; Nuria A Callejas; Raelene J Grumont; Corine Gillieron; Fabienne Mackay; Shane T Grey; Montserrat Camps; Christian Rommel; Steve D Gerondakis; Charles R Mackay
Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1.
Nature immunology 2006;7(3):274-83.
2005: Julie Wheway; Charles R Mackay; Rebecca A Newton; Amanda Sainsbury; Dana Boey; Herbert Herzog; Fabienne Mackay
A fundamental bimodal role for neuropeptide Y1 receptor in the immune system.
The Journal of experimental medicine 2005;202(11):1527-38.
2005: William Stohl; Dong Xu; Kyoung Soo Kim; Michael N Koss; Trine N Jorgensen; Bisram Deocharan; Troy E Metzger; Sarah A Bixler; Yeon Sik Hong; Christine Ambrose; Fabienne Mackay; Laurence Morel; Chaim Putterman; Brian L Kotzin; Susan L Kalled
BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus.
Arthritis and rheumatism 2005;52(7):2080-91.
2005: Andrew Sutherland; Lai Guan Ng; Carrie A Fletcher; Bennett O V Shum; Rebecca A Newton; Shane T Grey; Michael S Rolph; Fabienne Mackay; Charles R Mackay
BAFF augments certain Th1-associated inflammatory responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5537-44.
2005: Lai Guan Ng; Charles R Mackay; Fabienne Mackay
The BAFF/APRIL system: life beyond B lymphocytes.
Molecular immunology 2005;42(7):763-72.
2005: Danielle T Avery; Julia I Ellyard; Fabienne Mackay; Lynn M Corcoran; Philip D Hodgkin; Stuart G Tangye
Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4034-42.
2005: Fabienne Mackay; Frederic Sierro; Shane T Grey; Tom P Gordon
The BAFF/APRIL system: an important player in systemic rheumatic diseases.
Current directions in autoimmunity 2005;8():243-65.
2004: Ingrid Mecklenbräuker; Susan L Kalled; Michael Leitges; Fabienne Mackay; Alexander Tarakhovsky
Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling.
Nature 2004;431(7007):456-61.
2004: Svetlana Shulga-Morskaya; Max Dobles; Meghan E Walsh; Lai Guan Ng; Fabienne Mackay; Sambasiva P Rao; Susan L Kalled; Martin L Scott
B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2331-41.
2004: Fabienne Mackay; Stuart G Tangye
The role of the BAFF/APRIL system in B cell homeostasis and lymphoid cancers.
Current opinion in pharmacology 2004;4(4):347-54.
2004: Lai Guan Ng; Andrew Sutherland; Rebecca Newton; Fang Qian; Teresa G Cachero; Martin L Scott; Jeffrey S Thompson; Julie Wheway; Tatyana Chtanova; Joanna Groom; Ian J Sutton; Cynthia Xin; Stuart G Tangye; Susan L Kalled; Fabienne Mackay; Charles R Mackay
B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):807-17.
2004: Marilyn Thien; Tri Giang Phan; Sandra Gardam; Michelle Amesbury; Antony Basten; Fabienne Mackay; Robert Brink
Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.
Immunity 2004;20(6):785-98.
2004: Aubry Tardivel; Antoine Tinel; Susanne M A Lens; Quynh-Giao Steiner; Estelle Sauberli; Anne Wilson; Fabienne Mackay; Antonius G Rolink; Friedrich Beermann; Jürg Tschopp; Pascal Schneider
The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF.
European journal of immunology 2004;34(2):509-18.
2004: Marcel Batten; Carrie Fletcher; Lai Guan Ng; Joanna Groom; Julie Wheway; Yacine LAABI; Xiaoguan Xin; Pascal Schneider; Jürg Tschopp; Charles R Mackay; Fabienne Mackay
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):812-22.
2003: Danielle T Avery; Susan L Kalled; Julia I Ellyard; Christine Ambrose; Sarah A Bixler; Marilyn Thien; Robert Brink; Fabienne Mackay; Philip D Hodgkin; Stuart G Tangye
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.
The Journal of clinical investigation 2003;112(2):286-97.
2003: Fabienne Mackay; Christine Ambrose
The TNF family members BAFF and APRIL: the growing complexity.
Cytokine & growth factor reviews 2003;14(3-4):311-24.
2003: Fabienne Mackay; Pascal Schneider; Paul D Rennert; Jeffrey Browning
BAFF AND APRIL: a tutorial on B cell survival.
Annual review of immunology 2003;21():231-64.
2002: Fabienne Mackay; Susan L Kalled
TNF ligands and receptors in autoimmunity: an update.
Current opinion in immunology 2002;14(6):783-90.
2002: Jennifer L Gommerman; Fabienne Mackay; Elina Donskoy; Werner Meier; Pauline Martin; Jeffrey L Browning
Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway.
The Journal of clinical investigation 2002;110(9):1359-69.
2002: Fabienne Mackay; Jeffrey L Browning
BAFF: a fundamental survival factor for B cells.
Nature reviews. Immunology 2002;2(7):465-75.
2002: Joanna Groom; Susan L Kalled; Anne H Cutler; Carl Olson; Stephen A Woodcock; Pascal Schneider; Jürg Tschopp; Teresa G Cachero; Marcel Batten; Julie Wheway; Davide Mauri; Dana Cavill; Tom P Gordon; Charles R Mackay; Fabienne Mackay
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome.
The Journal of clinical investigation 2002;109(1):59-68.
2001: Pascal Schneider; H Takatsuka; Anne Wilson; Fabienne Mackay; Aubry Tardivel; Susanne M A Lens; Teresa G Cachero; Daniela Finke; Friedrich Beermann; Jürg Tschopp
Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen.
The Journal of experimental medicine 2001;194(11):1691-7.
2001: William J Simmons; M Simms; Roberto Chiarle; Fabienne Mackay; Vincent K Tsiagbe; J Browning; Giorgio Inghirami; GJ Thorbecke
Induction of germinal centers by MMTV encoded superantigen on B cells.
Developmental immunology 2001;8(3-4):201-11.
2000: Marcel Batten; Joanna Groom; Teresa G Cachero; Fang Qian; Pascal Schneider; Jürg Tschopp; Jeffrey L Browning; Fabienne Mackay
BAFF mediates survival of peripheral immature B lymphocytes.
The Journal of experimental medicine 2000;192(10):1453-66.
2000: Jeffrey S Thompson; Pascal Schneider; Susan L Kalled; L Wang; Eric A Lefevre; Teresa G Cachero; Fabienne Mackay; Sarah A Bixler; Mohammad Zafari; Z Y Liu; Stephen A Woodcock; Fang Qian; Marcel Batten; Christine Madry; Yolande Richard; Christopher D Benjamin; Jeffrey L Browning; Andréas Tsapis; Jürg Tschopp; Christine Ambrose
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population.
The Journal of experimental medicine 2000;192(1):129-35.
1999: Fabienne Mackay; Stephen A Woodcock; P Lawton; Christine Ambrose; Manfred Baetscher; Pascal Schneider; Jürg Tschopp; Jeffrey L Browning
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations.
The Journal of experimental medicine 1999;190(11):1697-710.
1999: Pascal Schneider; Fabienne Mackay; V Steiner; Kay Hofmann; Jean-Luc Bodmer; Nils Holler; Christine Ambrose; P Lawton; Sarah A Bixler; Hans Acha-Orbea; Danila Valmori; Pedro Romero; Christiane Werner-Favre; Rudolf H Zubler; Jeffrey L Browning; Jürg Tschopp
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
The Journal of experimental medicine 1999;189(11):1747-56.
1998: Fabienne Mackay; Jeffrey L Browning; P Lawton; SA Shah; Martina Comiskey; Atul K Bhan; Emiko Mizoguchi; Cox Terhorst; Stephen J Simpson
Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis.
Gastroenterology 1998;115(6):1464-75.
1998: Fabienne Mackay; Jeffrey L Browning
Turning off follicular dendritic cells.
Nature 1998;395(6697):26-7.
1998: Paul D Rennert; D James; Fabienne Mackay; Jeffrey L Browning; Paula S Hochman
Lymph node genesis is induced by signaling through the lymphotoxin beta receptor.
Immunity 1998;9(1):71-9.
1998: M Gonzalez; Fabienne Mackay; Jeffrey L Browning; M H Kosco-Vilbois; Randolph J Noelle
The sequential role of lymphotoxin and B cells in the development of splenic follicles.
The Journal of experimental medicine 1998;187(7):997-1007.
1997: Fabienne Mackay; PR Bourdon; D A Griffiths; P Lawton; Mohammad Zafari; Irene Sizing; Konrad Miatkowski; Apinya Ngam-Ek; Christopher D Benjamin; Cathy Hession; Christine Ambrose; Werner Meier; Jeffrey L Browning
Cytotoxic activities of recombinant soluble murine lymphotoxin-alpha and lymphotoxin-alpha beta complexes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3299-310.
1997: Fabienne Mackay; Gerard R Majeau; P Lawton; Paula S Hochman; Jeffrey L Browning
Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice.
European journal of immunology 1997;27(8):2033-42.
1996: Paul D Rennert; Jeffrey L Browning; Reina E Mebius; Fabienne Mackay; Paula S Hochman
Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs.
The Journal of experimental medicine 1996;184(5):1999-2006.
1996: Fabienne Mackay; Gerard R Majeau; Paula S Hochman; Jeffrey L Browning
Lymphotoxin beta receptor triggering induces activation of the nuclear factor kappaB transcription factor in some cell types.
The Journal of biological chemistry 1996;271(40):24934-8.
1996: Jeffrey L Browning; Konrad Miatkowski; Irene Sizing; D Griffiths; Mohammad Zafari; Christopher D Benjamin; Werner Meier; Fabienne Mackay
Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines.
The Journal of experimental medicine 1996;183(3):867-78.
1995: Paula S Hochman; Gerard R Majeau; Fabienne Mackay; Jeffrey L Browning
Proinflammatory responses are efficiently induced by homotrimeric but not heterotrimeric lymphotoxin ligands.
Journal of inflammation 1995;46(4):220-34.