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Susan Mackem

Research Profile

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Megan Bowers; Liane Eng; Xiaozhong Bao; Zhimin Lao; Susan Mackem; Elyn Riedel; Rowena K Turnbull; Alexandra L Joyner
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
Anne Gegonne; Terry Guinter; Jeffrey Hanson; Karen Hathcock; Susan Mackem; Daoud Meerzaman; Jaime Rodriguez-Canales; Alfred Singer; Xuguang Tai; Lino Tessarollo; Gang Wu; Zhihui Yang; Aki Yoshimoto; Jinghui Zhang; Jianjian Zhu; Ken Buetow; Qing-Rong Chen; Constance Cultraro; dinah singer
The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells.
Jianjian Zhu; Eiichiro Nakamura; Minh-Thanh Nguyen; Junming Yang; Susan Mackem
Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway.

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All Publications

2012: Megan Bowers; Liane Eng; Xiaozhong Bao; Zhimin Lao; Susan Mackem; Elyn Riedel; Rowena K Turnbull; Alexandra L Joyner
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
Developmental biology 2012;370(1):110-24.
2012: Anne Gegonne; Terry Guinter; Jeffrey Hanson; Karen Hathcock; Susan Mackem; Daoud Meerzaman; Jaime Rodriguez-Canales; Alfred Singer; Xuguang Tai; Lino Tessarollo; Gang Wu; Zhihui Yang; Aki Yoshimoto; Jinghui Zhang; Jianjian Zhu; Ken Buetow; Qing-Rong Chen; Constance Cultraro; dinah singer
The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells.
Molecular and cellular biology 2012;32(10):1984-97.
2012: Jianjian Zhu; Eiichiro Nakamura; Minh-Thanh Nguyen; Junming Yang; Susan Mackem
Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway.
Genesis (New York, N.Y. : 2000) 2012;50(2):102-11.
2011: Yongmei Wang; Daniel D Bikle; Zhiqiang Cheng; Thomas Landes Clemens; Hashem Z Elalieh; Susan Mackem; Eiichiro Nakamura; Minh-Thanh Nguyen; Wenhan Chang
IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(7):1437-46.
2011: Susan Mackem; Mark Lewandoski
Development. Limb cells don't tell time.
Science (New York, N.Y.) 2011;332(6033):1038-9.
2011: Jianjian Zhu; Susan Mackem
Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen.
Developmental dynamics : an official publication of the American Association of Anatomists 2011;240(5):1303-10.
2011: Derek E Gildea; Erin S Luetkemeier; Xiaozhong Bao; Stacie K Loftus; Susan Mackem; Yingzi Yang; william pavan; Leslie G Biesecker
The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(5):1596-605.
2011: Arjun Sebastian; Takehiko Matsushita; Aya Kawanami; Susan Mackem; Gary Landreth; Shunichi Murakami
Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2011;29(3):375-9.
2011: Mark Lewandoski; Susan Mackem
Developmental biology: extending the limb and body with vectors and scalars.
Current biology : CB 2011;21(1):R34-6.
2011: Takao Hirai; Andrei S Chagin; Tatsuya Kobayashi; Susan Mackem; Henry M Kronenberg
Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):191-6.
2011: Yoo Hun Suh; Aki Yoshimoto-Furusawa; Karis A Weih; Lino Tessarollo; Katherine W Roche; Susan Mackem; Paul A Roche
Deletion of SNAP-23 results in pre-implantation embryonic lethality in mice.
PloS one 2011;6(3):e18444.
2010: Christa Maes; Tatsuya Kobayashi; Martin K Selig; Sophie Torrekens; Sanford I Roth; Susan Mackem; Geert Carmeliet; Henry M Kronenberg
Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.
Developmental cell 2010;19(2):329-44.
2010: Kazu Matsumoto; Fumitoshi Irie; Susan Mackem; Yu Yamaguchi
A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(24):10932-7.
2010: Antonella Galli; Dimitri Robay; Marco Osterwalder; Xiaozhong Bao; Jean-Denis Bénazet; Muhammad Tariq; Renato Paro; Susan Mackem; Rolf Zeller
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.
PLoS genetics 2010;6(4):e1000901.
2009: Takahito Yuasa; Naoki Kondo; Rika Yasuhara; Kengo Shimono; Susan Mackem; Maurizio Pacifici; Masahiro Iwamoto; Motomi Enomoto-Iwamoto
Transient activation of Wnt/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice.
The American journal of pathology 2009;175(5):1993-2003.
2009: Mark Lewandoski; Susan Mackem
Limb development: the rise and fall of retinoic acid.
Current biology : CB 2009;19(14):R558-61.
2009: Minh-Thanh Nguyen; Jianjian Zhu; Eiichiro Nakamura; Xiaozhong Bao; Susan Mackem
Tamoxifen-dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbud.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(2):467-74.
2009: Keisuke Nagao; Jianjian Zhu; Mallorie B Heneghan; Jeffrey C Hanson; Maria I Morasso; Lino Tessarollo; Susan Mackem; Mark C Udey
Abnormal placental development and early embryonic lethality in EpCAM-null mice.
PloS one 2009;4(12):e8543.
2009: Susan Mackem; Mark Lewandoski
Limb development takes a measured step toward systems analysis.
Science signaling 2009;2(71):pe33.
2008: Jennifer Ohtola; John Myers; Batool Akhtar-Zaidi; Diana Zuzindlak; Pooja Sandesara; Karen Yeh; Susan Mackem; Radhika Atit
beta-Catenin has sequential roles in the survival and specification of ventral dermis.
Development (Cambridge, England) 2008;135(13):2321-9.
2008: Kinglun Kingston Mak; Henry M Kronenberg; Pao-Tien Chuang; Susan Mackem; Yingzi Yang
Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.
Development (Cambridge, England) 2008;135(11):1947-56.
2008: Jianjian Zhu; Eiichiro Nakamura; Minh-Thanh Nguyen; Xiaozhong Bao; Haruhiko Akiyama; Susan Mackem
Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.
Developmental cell 2008;14(4):624-32.
2007: Yukiko Maeda; Eiichiro Nakamura; Minh-Thanh Nguyen; Larry J Suva; Frances L Swain; Mohammed S Razzaque; Susan Mackem; Beate Lanske
Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6382-7.
2006: Eiichiro Nakamura; Minh-Thanh Nguyen; Susan Mackem
Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(9):2603-12.
2006: Takashi Furusawa; Jae-Hwan Lim; Frédéric Catez; Yehudit Birger; Susan Mackem; Michael Bustin
Down-regulation of nucleosomal binding protein HMGN1 expression during embryogenesis modulates Sox9 expression in chondrocytes.
Molecular and cellular biology 2006;26(2):592-604.
2004: Yuting Chen; Vladimir Knezevic; Valerie Ervin; Richard Hutson; Yvona Ward; Susan Mackem
Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh.
Development (Cambridge, England) 2004;131(10):2339-47.
2004: Chunqiao Liu; Vladimir Knezevic; Susan Mackem
Ventral tail bud mesenchyme is a signaling center for tail paraxial mesoderm induction.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;229(3):600-6.
2003: Chunqiao Liu; Eiichiro Nakamura; Vladimir Knezevic; Sherrie Hunter; Katherine Thompson; Susan Mackem
A role for the mesenchymal T-box gene Brachyury in AER formation during limb development.
Development (Cambridge, England) 2003;130(7):1327-37.
2001: Susan Mackem; Christopher T Baumann; Gordon L Hager
A glucocorticoid/retinoic acid receptor chimera that displays cytoplasmic/nuclear translocation in response to retinoic acid. A real time sensing assay for nuclear receptor ligands.
The Journal of biological chemistry 2001;276(49):45501-4.
2001: Vladimir Knezevic; Susan Mackem
Activation of epiblast gene expression by the hypoblast layer in the prestreak chick embryo.
Genesis (New York, N.Y. : 2000) 2001;30(4):264-73.
1999: Susan Mackem; Vladimir Knezevic
Do 5'Hoxd genes play a role in initiating or maintaining A-P polarizing signals in the limb?
Cell and tissue research 1999;296(1):27-31.
1998: Vladimir Knezevic; R De Santo; Susan Mackem
Continuing organizer function during chick tail development.
Development (Cambridge, England) 1998;125(10):1791-801.
1998: G Celli; WJ LaRochelle; Susan Mackem; Richard Sharp; Glenn Merlino
Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning.
The EMBO journal 1998;17(6):1642-55.
1997: Vladimir Knezevic; R De Santo; K Schughart; U Huffstadt; Chin Chiang; Kathleen A Mahon; Susan Mackem
Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop.
Development (Cambridge, England) 1997;124(22):4523-36.
1997: Vladimir Knezevic; R De Santo; Susan Mackem
Two novel chick T-box genes related to mouse Brachyury are expressed in different, non-overlapping mesodermal domains during gastrulation.
Development (Cambridge, England) 1997;124(2):411-9.
1996: E Hermesz; Susan Mackem; Kathleen A Mahon
Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo.
Development (Cambridge, England) 1996;122(1):41-52.
1995: Vladimir Knezevic; M Ranson; Susan Mackem
The organizer-associated chick homeobox gene, Gnot1, is expressed before gastrulation and regulated synergistically by activin and retinoic acid.
Developmental biology 1995;171(2):458-70.
1995: M Ranson; C Tickle; Kathleen A Mahon; Susan Mackem
Gnot1, a member of a new homeobox gene subfamily, is expressed in a dynamic, region-specific domain along the proximodistal axis of the developing limb.
Mechanisms of development 1995;51(1):17-30.
1993: Susan Mackem; M Ranson; Kathleen A Mahon
Limb-type differences in expression domains of certain chick Hox-4 genes and relationship to pattern modification for flight.
Progress in clinical and biological research 1993;383A():21-30.
1991: Susan Mackem; Kathleen A Mahon
Ghox 4.7: a chick homeobox gene expressed primarily in limb buds with limb-type differences in expression.
Development (Cambridge, England) 1991;112(3):791-806.