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Ian Mackenzie

Research Profile

Disorders

Anatomy

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Immunohistochemistry

Physiology

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Kohji Mori; Manuela Neumann; Christine Van Broeckhoven; Sonja Zilow; Thomas Arzberger; Marc Cruts; Dieter Edbauer; Ignasi Forné; Jochen Herms; Jonathan Janssens; Gernot Kleinberger; Hans A Kretzschmar; Sven Lammich; Ian R A Mackenzie; Christian Haass
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations.
Dorothee Dormann; Claudia Abou-Ajram; Olaf Ansorge; Eva Bentmann; Elisabeth Kremmer; Ian R A Mackenzie; Tobias Madl; Manuela Neumann; Sabina Tahirovic; Chiara F Valori; Christian Haass
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.
Manuela Neumann; Chiara F Valori; Osamu Yokota; David G Munoz; Lee Cyn Ang; Olaf Ansorge; Juan M Bilbao; Kenji Ishihara; Hans A Kretzschmar; Hirofumi Kusaka; Ian R A Mackenzie
Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

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All Publications

2013: Kohji Mori; Manuela Neumann; Christine Van Broeckhoven; Sonja Zilow; Thomas Arzberger; Marc Cruts; Dieter Edbauer; Ignasi Forné; Jochen Herms; Jonathan Janssens; Gernot Kleinberger; Hans A Kretzschmar; Sven Lammich; Ian R A Mackenzie; Christian Haass
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations.
Acta neuropathologica 2013;125(3):413-23.
2012: Dorothee Dormann; Claudia Abou-Ajram; Olaf Ansorge; Eva Bentmann; Elisabeth Kremmer; Ian R A Mackenzie; Tobias Madl; Manuela Neumann; Sabina Tahirovic; Chiara F Valori; Christian Haass
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.
The EMBO journal 2012;31(22):4258-75.
2012: Manuela Neumann; Chiara F Valori; Osamu Yokota; David G Munoz; Lee Cyn Ang; Olaf Ansorge; Juan M Bilbao; Kenji Ishihara; Hans A Kretzschmar; Hirofumi Kusaka; Ian R A Mackenzie
Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.
Acta neuropathologica 2012;124(5):705-16.
2012: B W Wang; M Assaly; B L Beattie; Claudia Jacova; Philip E Lee; E Lu; Ian R A Mackenzie; Ging-Yuek R Hsiung
Multiple pathologies are common in Alzheimer patients in clinical trials.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2012;39(5):592-9.
2012: Glenda Halliday; Ian R A Mackenzie; Eileen H Bigio; Nigel J Cairns; Manuela Neumann; David M A Mann
Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects.
Acta neuropathologica 2012;124(3):373-82.
2012: Ian R A Mackenzie; Manuela Neumann
FET proteins in frontotemporal dementia and amyotrophic lateral sclerosis.
Brain research 2012;1462():40-3.
2012: Ging-Yuek R Hsiung; Bonnie Leung; Rosa Rademakers; Nicola J Rutherford; Pheth Sengdy; Matt Baker; Phoenix Bouchard-Kerr; Rachel Butler; Mariely DeJesus-Hernandez; Emily Dwosh; Howard H Feldman; Alice Fok; Ian R A Mackenzie
Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p.
Brain : a journal of neurology 2012;135(Pt 3):709-22.
2012: Heather Stewart; Rosa Rademakers; Nicola J Rutherford; Matt Baker; Hannah Briemberg; Neil Cashman; Mariely DeJesus-Hernandez; Andrew Eisen; Marife Fabros; Alice Fok; Charles Krieger; Ian R A Mackenzie
Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p.
Acta neuropathologica 2012;123(3):409-17.
2012: Tawny Hung; Ronald C Neafie; Ian R A Mackenzie
Baylisascaris procyonis infection in elderly person, British Columbia, Canada.
Emerging infectious diseases 2012;18(2):341-2.
2012: Terri L Petkau; Lynn A Raymond; Howard H Feldman; Jenny Gregg; Austin M Hill; Ge Lu; Ian R A Mackenzie; Ada Mew; Austen Milnerwood; Scott J Neal; Paul C Orban; Blair R Leavitt
Synaptic dysfunction in progranulin-deficient mice.
Neurobiology of disease 2012;45(2):711-22.
2011: Richard A Armstrong; Eileen H Bigio; Felix F Cruz-Sanchez; Charles Duyckaerts; Marla Gearing; Ian R A Mackenzie; Robert H Perry; Kari Skullerud; Hideaki Yokoo; Nigel J Cairns
Spatial patterns of FUS-immunoreactive neuronal cytoplasmic inclusions (NCI) in neuronal intermediate filament inclusion disease (NIFID).
Journal of neural transmission (Vienna, Austria : 1996) 2011;118(11):1651-7.
2011: Ian R A Mackenzie; David G Munoz; Manuela Neumann; Nigel J Cairns; Adrian M Isaacs
Novel types of frontotemporal lobar degeneration: beyond tau and TDP-43.
Journal of molecular neuroscience : MN 2011;45(3):402-8.
2011: Mariely DeJesus-Hernandez; Dennis W Dickson; Howard Feldman; NiCole A Finch; Heather Flynn; Daniel Geschwind; Neill R Graff-Radford; Ging-Yuek R Hsiung; Keith A Josephs; Anna Karydas; David S Knopman; Naomi Kouri; Ian R A Mackenzie; Bruce L Miller; Alexandra M Nicholson; Ronald C Petersen; Jennifer Adamson; Matt Baker; Bradley F Boeve; Adam L Boxer; Kevin B Boylan; Giovanni Coppola; Nicola J Rutherford; William W Seeley; Pheth Sengdy; Aleksandra Wojtas; Zbigniew K Wszolek; Rosa Rademakers
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS.
Neuron 2011;72(2):245-56.
2011: Manuela Neumann; Rosa Rademakers; Sigrun Roeber; Osamu Yokota; David G Munoz; Lee Cyn Ang; Olaf Ansorge; Eva Bentmann; Juan Bilbao; Mariely DeJesus-Hernandez; Dorothee Dormann; Christian Haass; Ali Jawaid; Hans A Kretzschmar; Hirofumi Kusaka; Ian R A Mackenzie
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.
Brain : a journal of neurology 2011;134(Pt 9):2595-609.
2011: Ian R A Mackenzie; David M A Mann; Manuela Neumann; Robert H Perry; Deepak M Sampathu; John Q Trojanowski; Atik Baborie; Daniel Du Plessis; Evelyn Jaros; Virginia M-Y Lee
A harmonized classification system for FTLD-TDP pathology.
Acta neuropathologica 2011;122(1):111-3.
2011: Ian R A Mackenzie; Lee Cyn Ang; Olaf Ansorge; Matt Baker; Juan Bilbao; Andrew Eisen; Rosa Rademakers; Heather Stewart; Michael Strong; Lorne H Zinman; Manuela Neumann
Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation.
Acta neuropathologica 2011;122(1):87-98.
2011: Ian R A Mackenzie; David G Munoz; Hirofumi Kusaka; Osamu Yokota; Kenji Ishihara; Sigrun Roeber; Hans A Kretzschmar; Nigel J Cairns; Manuela Neumann
Distinct pathological subtypes of FTLD-FUS.
Acta neuropathologica 2011;121(2):207-18.
2011: Richard A Armstrong; Marla Gearing; Eileen H Bigio; Felix F Cruz-Sanchez; Charles Duyckaerts; Ian R A Mackenzie; Robert H Perry; Kari Skullerud; Hedeaki Yokoo; Nigel J Cairns
The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease.
Acta neuropathologica 2011;121(2):219-28.
2011: Adam L Boxer; Ian R A Mackenzie; Bradley Boeve; Matthew Baker; William W Seeley; Richard Crook; Howard Feldman; Ging-Yuek R Hsiung; Nicola Rutherford; Victor Laluz; Jennifer Whitwell; Dean Foti; Eric McDade; Jennifer Molano; Anna Karydas; Aleksandra Wojtas; Jill Goldman; Jacob Mirsky; Pheth Sengdy; Stephen Dearmond; Bruce L Miller; Rosa Rademakers
Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family.
Journal of neurology, neurosurgery, and psychiatry 2011;82(2):196-203.
2011: Ging-Yuek R Hsiung; Alice Fok; Howard H Feldman; Rosa Rademakers; Ian R A Mackenzie
rs5848 polymorphism and serum progranulin level.
Journal of the neurological sciences 2011;300(1-2):28-32.
2010: Dorothee Dormann; Ramona Rodde; Dieter Edbauer; Eva Bentmann; Ingeborg Fischer; Alexander Hruscha; Manuel E Than; Ian R A Mackenzie; Anja Capell; Bettina Schmid; Manuela Neumann; Christian Haass
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.
The EMBO journal 2010;29(16):2841-57.
2010: Rosa Rademakers; Heather Stewart; Mariely Dejesus-Hernandez; Charles Krieger; Neill Graff-Radford; Marife Fabros; Hannah Briemberg; Neil Cashman; Andrew Eisen; Ian R A Mackenzie
Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis.
Muscle & nerve 2010;42(2):170-6.
2010: John Woulfe; Douglas A Gray; Ian R A Mackenzie
FUS-immunoreactive intranuclear inclusions in neurodegenerative disease.
Brain pathology (Zurich, Switzerland) 2010;20(3):589-97.
2010: Richard A Armstrong; William G Ellis; Ronald L Hamilton; Ian R A Mackenzie; John Hedreen; Marla Gearing; Thomas Montine; Jean-Paul Vonsattel; Elizabeth Head; Andrew P Lieberman; Nigel J Cairns
Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis.
Journal of neural transmission (Vienna, Austria : 1996) 2010;117(2):227-39.
2010: Ian R A Mackenzie; Manuela Neumann; Eileen H Bigio; Nigel J Cairns; Irina Alafuzoff; Jillian Kril; Gabor Geza Kovacs; Bernardino Ghetti; Glenda Halliday; Ida E Holm; Paul Geoffrey Ince; Wouter Kamphorst; Tamas Revesz; Annemieke J M Rozemuller; Samir Kumar-Singh; Haruhiko Akiyama; Atik Baborie; Salvatore Spina; dennis dickson; John Q Trojanowski; D M A Mann
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update.
Acta neuropathologica 2010;119(1):1-4.
2009: Ida Elisabeth Holm; Adrian M Isaacs; Ian R A Mackenzie
Absence of FUS-immunoreactive pathology in frontotemporal dementia linked to chromosome 3 (FTD-3) caused by mutation in the CHMP2B gene.
Acta neuropathologica 2009;118(5):719-20.
2009: Manuela Neumann; Rosa Rademakers; Sigrun Roeber; Matt Baker; Hans A Kretzschmar; Ian R A Mackenzie
A new subtype of frontotemporal lobar degeneration with FUS pathology.
Brain : a journal of neurology 2009;132(Pt 11):2922-31.
2009: Manuela Neumann; Sigrun Roeber; Hans A Kretzschmar; Rosa Rademakers; Matt Baker; Ian R A Mackenzie
Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease.
Acta neuropathologica 2009;118(5):605-16.
2009: Tetsuaki Arai; Ian R A Mackenzie; Masato Hasegawa; Takashi Nonoka; Kazhuhiro Niizato; Kuniaki Tsuchiya; Shuji Iritani; Mitsumoto Onaya; Haruhiko Akiyama
Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.
Acta neuropathologica 2009;117(2):125-36.
2009: Manuela Neumann; Markus Tolnay; Ian R A Mackenzie
The molecular basis of frontotemporal dementia.
Expert reviews in molecular medicine 2009;11():e23.
2009: Ian R A Mackenzie; Manuela Neumann; Eileen H Bigio; Nigel J Cairns; Irina Alafuzoff; Jillian Kril; Gabor Geza Kovacs; Bernardino Ghetti; Glenda Halliday; Ida E Holm; Paul Geoffrey Ince; Wouter Kamphorst; Tamas Revesz; Annemieke J M Rozemuller; Samir Kumar-Singh; Haruhiko Akiyama; Atik Baborie; Salvatore Spina; dennis dickson; John Q Trojanowski; D M A Mann
Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations.
Acta neuropathologica 2009;117(1):15-8.
2008: Ian R A Mackenzie; Rosa Rademakers
The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia.
Current opinion in neurology 2008;21(6):693-700.
2008: Howard H Feldman; Luis F Maia; Ian R A Mackenzie; Bruce B Forster; Jeff Martzke; Andrew Woolfenden
Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease.
Stroke; a journal of cerebral circulation 2008;39(10):2894-7.
2008: Sigrun Roeber; Ian R A Mackenzie; Hans A Kretzschmar; Manuela Neumann
TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD.
Acta neuropathologica 2008;116(2):147-57.
2008: Ian R A Mackenzie; Dean Foti; John Woulfe; Trevor A Hurwitz
Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions.
Brain : a journal of neurology 2008;131(Pt 5):1282-93.
2008: Jason Eriksen; Ian R A Mackenzie
Progranulin: normal function and role in neurodegeneration.
Journal of neurochemistry 2008;104(2):287-97.
2007: Bradley J Hallam; Noah D Silverberg; Amanda K Lamarre; Ian R A Mackenzie; Howard H Feldman
Clinical presentation of prodromal frontotemporal dementia.
American journal of Alzheimer's disease and other dementias 2007;22(6):456-67.
2007: Ian R A Mackenzie; Rosa Rademakers
The molecular genetics and neuropathology of frontotemporal lobar degeneration: recent developments.
Neurogenetics 2007;8(4):237-48.
2007: Julie S Snowden; Stuart M Pickering-Brown; Daniel Du Plessis; Ian R A Mackenzie; Anoop Varma; D M A Mann; David Neary
Progressive anomia revisited: focal degeneration associated with progranulin gene mutation.
Neurocase 2007;13(5):366-77.
2007: Ian R A Mackenzie
The neuropathology of FTD associated With ALS.
Alzheimer disease and associated disorders 2007;21(4):S44-9.
2007: Ida Elisabeth Holm; Elisabet Englund; Ian R A Mackenzie; Peter Johannsen; Adrian M Isaacs
A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3.
Journal of neuropathology and experimental neurology 2007;66(10):884-91.
2007: Nigel J Cairns; Manuela Neumann; Eileen H Bigio; Ida E Holm; Dirk Troost; Kimmo J Hatanpaa; Chan Foong; Charles L White; Julie A Schneider; Hans A Kretzschmar; Deborah Carter; Lisa Taylor-Reinwald; Katherine Paulsmeyer; Jeffrey Strider; Michael Gitcho; Alison Goate; John C Morris; Manjari Mishra; Linda K Kwong; Anna Stieber; Yan Xu; Mark S Forman; John Q Trojanowski; Virginia M-Y Lee; Ian R A Mackenzie
TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.
The American journal of pathology 2007;171(1):227-40.
2007: Nigel J Cairns; Eileen H Bigio; Ian R A Mackenzie; Manuela Neumann; Virginia M-Y Lee; Kimmo J Hatanpaa; Charles L White; Julie A Schneider; Lea Tenenholz Grinberg; Glenda Halliday; Charles Duyckaerts; James S Lowe; Ida E Holm; Markus Tolnay; Koichi Okamoto; Hideaki Yokoo; Shigeo Murayama; John Woulfe; David G Munoz; dennis dickson; Paul Geoffrey Ince; John Q Trojanowski; D M A Mann
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration.
Acta neuropathologica 2007;114(1):5-22.
2007: Ian R A Mackenzie
The neuropathology and clinical phenotype of FTD with progranulin mutations.
Acta neuropathologica 2007;114(1):49-54.
2007: Luís F Maia; Ian R A Mackenzie; Howard H Feldman
Clinical phenotypes of Cerebral Amyloid Angiopathy.
Journal of the neurological sciences 2007;257(1-2):23-30.
2007: Jeremy M van Raamsdonk; Zoe Murphy; David M Selva; Reza Hamidizadeh; Jacqueline Pearson; Asa Petersén; Maria Björkqvist; Cameron Muir; Ian R A Mackenzie; Geoffrey L Hammond; A Wayne Vogl; Michael R Hayden; Blair R Leavitt
Testicular degeneration in Huntington disease.
Neurobiology of disease 2007;26(3):512-20.
2007: Ian R A Mackenzie; Eileen H Bigio; Paul Geoffrey Ince; Felix Geser; Manuela Neumann; Nigel J Cairns; Linda K Kwong; Mark S Forman; John Ravits; Heather Stewart; Andrew Eisen; Leo McClusky; Hans A Kretzschmar; Camelia M Monoranu; J Robin Highley; Janine Kirby; Teepu Siddique; Pamela J Shaw; Virginia M-Y Lee; John Q Trojanowski
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Annals of neurology 2007;61(5):427-34.
2007: Yvonne Davidson; Thomas Kelley; Ian R A Mackenzie; Stuart Pickering-Brown; Daniel Du Plessis; David Neary; Julie S Snowden; D M A Mann
Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43.
Acta neuropathologica 2007;113(5):521-33.
2007: Manuela Neumann; Ian R A Mackenzie; Nigel J Cairns; Philip J Boyer; William R Markesbery; Charles D Smith; J. Paul Taylor; Hans A Kretzschmar; Virginia E Kimonis; Mark S Forman
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
Journal of neuropathology and experimental neurology 2007;66(2):152-7.
2007: Zeshan Ahmed; Ian R A Mackenzie; Michael Hutton; dennis dickson
Progranulin in frontotemporal lobar degeneration and neuroinflammation.
Journal of neuroinflammation 2007;4():7.
2006: Stuart Pickering-Brown; Matt Baker; Jennifer Gass; Bradley Boeve; Clement T Loy; William S Brooks; Ian R A Mackenzie; Ralph N Martins; John B J Kwok; Linda Truong; Jillian J Kril; Peter R Schofield; D M A Mann; Michael Hutton
Mutations in progranulin explain atypical phenotypes with variants in MAPT.
Brain : a journal of neurology 2006;129(Pt 11):3124-6.
2006: Ian R A Mackenzie; Matt Baker; Stuart Pickering-Brown; Ging-Yuek R Hsiung; Caroline Lindholm; Emily Dwosh; Jennifer Gass; Ashley Cannon; Rosa Rademakers; Michael Hutton; Howard H Feldman
The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene.
Brain : a journal of neurology 2006;129(Pt 11):3081-90.
2006: Ian R A Mackenzie; Atik Baborie; Stuart Pickering-Brown; Daniel Du Plessis; Evelyn Jaros; Robert H Perry; David Neary; Julie S Snowden; D M A Mann
Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype.
Acta neuropathologica 2006;112(5):539-49.
2006: Julie S Snowden; Stuart Pickering-Brown; Ian R A Mackenzie; A M T Richardson; Anoop Varma; David Neary; D M A Mann
Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia.
Brain : a journal of neurology 2006;129(Pt 11):3091-102.
2006: Ian R A Mackenzie; Jing Shi; Catherine L Shaw; Daniel Duplessis; David Neary; Julie S Snowden; D M A Mann
Dementia lacking distinctive histology (DLDH) revisited.
Acta neuropathologica 2006;112(5):551-9.
2006: Jennifer Gass; Ashley Cannon; Ian R A Mackenzie; Bradley Boeve; Matt Baker; Jennifer Adamson; Richard Crook; Stacey Melquist; Karen Kuntz; Ronald C. Petersen; Keith A Josephs; Stuart Pickering-Brown; Neill R Graff-Radford; Ryan Uitti; dennis dickson; Zbigniew K Wszolek; John Gonzalez; Thomas Beach; Eileen H Bigio; Nancy Johnson; Sandra Weintraub; Marek-Marsel Mesulam; Charles L White; Bryan Woodruff; Richard Caselli; Ging-Yuek Hsiung; Howard Feldman; David S. Knopman; Michael Hutton; Rosa Rademakers
Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration.
Human molecular genetics 2006;15(20):2988-3001.
2006: Manuela Neumann; Deepak M Sampathu; Linda K Kwong; Adam C Truax; Matthew Micsenyi; Thomas T Chou; Jennifer Bruce; Theresa Schuck; Murray Grossman; Christopher M Clark; Leo McCluskey; Bruce L Miller; Eliezer Masliah; Ian R A Mackenzie; Howard Feldman; Wolfgang Feiden; Hans A Kretzschmar; John Q Trojanowski; Virginia M-Y Lee
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.) 2006;314(5796):130-3.
2006: Matt Baker; Ian R A Mackenzie; Stuart Pickering-Brown; Jennifer Gass; Rosa Rademakers; Caroline Lindholm; Julie Snowden; Jennifer Adamson; A Dessa Sadovnick; Sara Rollinson; Ashley Cannon; Emily Dwosh; David Neary; Stacey Melquist; Anna Richardson; dennis dickson; Zdenek Berger; Jason Eriksen; Todd Robinson; Cynthia Zehr; Chad A Dickey; Richard Crook; Eileen McGowan; D M A Mann; Bradley Boeve; Howard Feldman; Michael Hutton
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.
Nature 2006;442(7105):916-9.
2006: Zbigniew K Wszolek; Yasuhiko Baba; Ian R A Mackenzie; Ryan Uitti; Audrey Strongosky; Daniel F Broderick; Matthew C Baker; Stacey Melquist; Michael Hutton; Yoshio Tsuboi; J E Allanson; J Carr; A Kumar; Susan M Calne; Judith Miklossy; Patrick L McGeer; Donald B Calne; A Jon Stoessl
Autosomal dominant dystonia-plus with cerebral calcifications.
Neurology 2006;67(4):620-5.
2006: Mark S Forman; Ian R A Mackenzie; Nigel J Cairns; Eric Swanson; Philip J Boyer; David Drachman; Bharati S Jhaveri; Jason H T Karlawish; Alan Pestronk; Thomas W Smith; Pang-hsien Tu; Giles D J Watts; William R Markesbery; Charles D Smith; Virginia E Kimonis
Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations.
Journal of neuropathology and experimental neurology 2006;65(6):571-81.
2006: Ian R A Mackenzie; Matthew Baker; Gemma West; John Woulfe; Najeeb Qadi; Jennifer Gass; Ashley Cannon; Jennifer Adamson; Howard Feldman; Caroline Lindholm; Stacey Melquist; Rachel Pettman; A Dessa Sadovnick; Emily Dwosh; Sidney W Whiteheart; Michael Hutton; Stuart Pickering-Brown
A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17.
Brain : a journal of neurology 2006;129(Pt 4):853-67.
2006: Julia Mills; Agnieszka Niewmierzycka; Arusha Oloumi; Beatriz Rico; René St-Arnaud; Ian R A Mackenzie; Nasrin M Mawji; Jason Wilson; Louis F Reichardt; Shoukat Dedhar
Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(3):830-40.
2006: Ian R A Mackenzie; Stefanie L Butland; Rebecca S Devon; Emily Dwosh; Howard Feldman; Caroline Lindholm; Scott J Neal; B F Francis Ouellette; Blair R Leavitt
Familial frontotemporal dementia with neuronal intranuclear inclusions is not a polyglutamine expansion disease.
BMC neurology 2006;6():32.
2006: Nigel J Cairns; Eileen H Bigio; Ian R A Mackenzie
Letter to the editor.
Journal of neuropathology and experimental neurology 2006;65(1):97; author reply 97-8.
2005: Ian R A Mackenzie; Howard H Feldman
Ubiquitin immunohistochemistry suggests classic motor neuron disease, motor neuron disease with dementia, and frontotemporal dementia of the motor neuron disease type represent a clinicopathologic spectrum.
Journal of neuropathology and experimental neurology 2005;64(8):730-9.
2005: Judith Miklossy; Ian R A Mackenzie; Katerina Dorovini-Zis; Donald B Calne; Zbigniew K Wszolek; Andis Klegeris; Patrick L McGeer
Severe vascular disturbance in a case of familial brain calcinosis.
Acta neuropathologica 2005;109(6):643-53.
2004: Nigel J Cairns; Murray Grossman; Steven E Arnold; David J Burn; Evelyn Jaros; Robert H Perry; Charles Duyckaerts; B Stankoff; B Pillon; Kari Skullerud; F F Cruz-Sanchez; Eileen H Bigio; Ian R A Mackenzie; Marla Gearing; Jorge L Juncos; Jonathan D Glass; Hideaki Yokoo; Yoichi Nakazato; Sabrina Mosaheb; Julian R Thorpe; Kunihiro Uryu; Virginia M-Y Lee; John Q Trojanowski
Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease.
Neurology 2004;63(8):1376-84.
2004: Nigel J Cairns; Kunihiro Uryu; Eileen H Bigio; Ian R A Mackenzie; Marla Gearing; Charles Duyckaerts; Hideaki Yokoo; Yoichi Nakazato; Evelyn Jaros; Robert H Perry; Steven E Arnold; Virginia M-Y Lee; John Q Trojanowski
alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases.
Acta neuropathologica 2004;108(3):213-23.
2004: Ian R A Mackenzie; Howard Feldman
Neurofilament inclusion body disease with early onset frontotemporal dementia and primary lateral sclerosis.
Clinical neuropathology 2004;23(4):183-93.
2004: Nigel J Cairns; Victoria Zhukareva; Kunihiro Uryu; Bin Zhang; Eileen H Bigio; Ian R A Mackenzie; Marla Gearing; Charles Duyckaerts; Hideaki Yokoo; Yoichi Nakazato; Evelyn Jaros; Robert H Perry; Virginia M-Y Lee; John Q Trojanowski
alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease.
The American journal of pathology 2004;164(6):2153-61.
2004: Ian R A Mackenzie; Howard Feldman
Extrapyramidal features in patients with motor neuron disease and dementia; a clinicopathological correlative study.
Acta neuropathologica 2004;107(4):336-40.
2004: Ian R A Mackenzie; Howard Feldman
Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases.
Dementia and geriatric cognitive disorders 2004;17(4):333-6.
2003: Peerooz Saeed; Jack Rootman; Robert A Nugent; Valerie A White; Ian R A Mackenzie; Leo Koornneef
Optic nerve sheath meningiomas.
Ophthalmology 2003;110(10):2019-30.
2003: Ian R A Mackenzie; Howard Feldman
Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases.
Acta neuropathologica 2003;105(6):543-8.
2003: Ian R A Mackenzie; Howard Feldman
The relationship between extramotor ubiquitin-immunoreactive neuronal inclusions and dementia in motor neuron disease.
Acta neuropathologica 2003;105(2):98-102.
2003: David G Munoz; dennis dickson; Catherine Bergeron; Ian R A Mackenzie; André Delacourte; Victoria Zhukareva
The neuropathology and biochemistry of frontotemporal dementia.
Annals of neurology 2003;54 Suppl 5():S24-8.
2000: Ian R A Mackenzie
Activated microglia in dementia with Lewy bodies.
Neurology 2000;55(1):132-4.
2000: Ian R A Mackenzie
Anti-inflammatory drugs and Alzheimer-type pathology in aging.
Neurology 2000;54(3):732-4.
1998: Ian R A Mackenzie; David G Munoz
Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging.
Neurology 1998;50(4):986-90.