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Peter Mackenzie

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Yuji Ishii; Peter I Mackenzie; Yuu Miyauchi; Naoko Iida; Hideyuki Yamada
Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols.
Shuso Takeda; Yuji Ishii; Megumi Iwanaga; Arief Nurrochmad; Yuji Ito; Peter I Mackenzie; Kiyoshi Nagata; Yasushi Yamazoe; Kazuta Oguri; Hideyuki Yamada
Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction.
Yoshio Nishimura; Shingo Maeda; Shin-ichi Ikushiro; Peter I Mackenzie; Yuji Ishii; Hideyuki Yamada
Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanism.

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All Publications

2012: Yuji Ishii; Peter I Mackenzie; Yuu Miyauchi; Naoko Iida; Hideyuki Yamada
Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols.
Biological & pharmaceutical bulletin 2012;35(10):1811-7.
2009: Shuso Takeda; Yuji Ishii; Megumi Iwanaga; Arief Nurrochmad; Yuji Ito; Peter I Mackenzie; Kiyoshi Nagata; Yasushi Yamazoe; Kazuta Oguri; Hideyuki Yamada
Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction.
Molecular pharmacology 2009;75(4):956-64.
2007: Yoshio Nishimura; Shingo Maeda; Shin-ichi Ikushiro; Peter I Mackenzie; Yuji Ishii; Hideyuki Yamada
Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanism.
Biochimica et biophysica acta 2007;1770(11):1557-66.
2007: Yuji Ishii; Megumi Iwanaga; Yoshio Nishimura; Shuso Takeda; Shin-ichi Ikushiro; Kiyoshi Nagata; Yasushi Yamazoe; Peter I Mackenzie; Hideyuki Yamada
Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex.
Drug metabolism and pharmacokinetics 2007;22(5):367-76.
2006: Shuso Takeda; Yurie Kitajima; Yuji Ishii; Yoshio Nishimura; Peter I Mackenzie; Kazuta Oguri; Hideyuki Yamada
Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(8):1277-82.
2006: Kazuharu Okamura; Yuji Ishii; Shin-ichi Ikushiro; Peter I Mackenzie; Hideyuki Yamada
Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferases.
Biochemical and biophysical research communications 2006;345(4):1649-56.
2005: Shuso Takeda; Yuji Ishii; Peter I Mackenzie; Kiyoshi Nagata; Yasushi Yamazoe; Kazuta Oguri; Hideyuki Yamada
Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4.
Biological & pharmaceutical bulletin 2005;28(10):2026-7.
2005: Shuso Takeda; Yuji Ishii; Megumi Iwanaga; Peter I Mackenzie; Kiyoshi Nagata; Yasushi Yamazoe; Kazuta Oguri; Hideyuki Yamada
Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4.
Molecular pharmacology 2005;67(3):665-72.