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Peter Macklem

Research Profile

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Publications

TOP 3
Andrew J E Seely; Stuart A Kauffman; Jason H T Bates; Peter T Macklem; Béla Suki; John C Marshall; Andriy I Batchinsky; Jose Luis Perez-Velazquez; Adam Seiver; Carolyn McGregor; Geoffrey Maksym; Markad V Kamath; Thomas Similowski; Timothy G Buchman; Christophe Letellier; Marcel Filoche; Martin G Frasch; Christian Straus; Leon Glass; Paul J Godin; John A Morris; Daby Sow; Vera Nenadovic; Ryan C Arnold; Patrick Norris; J Randall Moorman
Proceedings from the Montebello Round Table Discussion. Second annual conference on Complexity and Variability discusses research that brings innovation to the bedside.
Peter T Macklem
Susceptibility to exacerbation in COPD.
Andrea Aliverti; Barbara Uva; Marianna Laviola; Dario Bovio; Antonella Lo Mauro; Cantor Tarperi; Edoardo Colombo; Bryan Loomas; Antonio Pedotti; Thomas Similowski; Peter T Macklem
Concomitant ventilatory and circulatory functions of the diaphragm and abdominal muscles.

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All Publications

2011: Andrew J E Seely; Stuart A Kauffman; Jason H T Bates; Peter T Macklem; Béla Suki; John C Marshall; Andriy I Batchinsky; Jose Luis Perez-Velazquez; Adam Seiver; Carolyn McGregor; Geoffrey Maksym; Markad V Kamath; Thomas Similowski; Timothy G Buchman; Christophe Letellier; Marcel Filoche; Martin G Frasch; Christian Straus; Leon Glass; Paul J Godin; John A Morris; Daby Sow; Vera Nenadovic; Ryan C Arnold; Patrick Norris; J Randall Moorman
Proceedings from the Montebello Round Table Discussion. Second annual conference on Complexity and Variability discusses research that brings innovation to the bedside.
Journal of critical care 2011;26(3):325-7.
2010: Peter T Macklem
Susceptibility to exacerbation in COPD.
The New England journal of medicine 2010;363(27):2670; author reply 2671.
2010: Andrea Aliverti; Barbara Uva; Marianna Laviola; Dario Bovio; Antonella Lo Mauro; Cantor Tarperi; Edoardo Colombo; Bryan Loomas; Antonio Pedotti; Thomas Similowski; Peter T Macklem
Concomitant ventilatory and circulatory functions of the diaphragm and abdominal muscles.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;109(5):1432-40.
2010: Peter T Macklem
Stephen Hales, an unrecognized giant of medicine.
Osler Library newsletter 2010;(114):1-4.
2010: Peter T Macklem; Andrew Seely
Towards a definition of life.
Perspectives in biology and medicine 2010;53(3):330-40.
2009: Peter T Macklem
In memoriam: Jere Mead (1920-2009).
Journal of applied physiology (Bethesda, Md. : 1985) 2009;107(6):1679.
2009: Caterina Salito; Andrea Aliverti; David S Gierada; Gaetan Deslée; Richard A Pierce; Peter T Macklem; Jason C Woods
Quantification of trapped gas with CT and 3 He MR imaging in a porcine model of isolated airway obstruction.
Radiology 2009;253(2):380-9.
2009: Andrea Aliverti; Dario Bovio; Irene Fullin; Raffaele L Dellacà; A Lo Mauro; Antonio Pedotti; Peter T Macklem
The abdominal circulatory pump.
PloS one 2009;4(5):e5550.
2008: Cliff K Choong; Peter T Macklem; John A Pierce; Nitin Das; Barbara A Lutey; Carlo O Martinez; Joel D Cooper
Airway bypass improves the mechanical properties of explanted emphysematous lungs.
American journal of respiratory and critical care medicine 2008;178(9):902-5.
2008: Andrea Aliverti; Peter T Macklem
Last Word on Point:Counterpoint: The major limitation to exercise performance in COPD is 1) inadequate energy supply to the respiratory and locomotor muscles, 2) lower limb muscle dysfunction, 3) dynamic hyperinflation.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(2):763.
2008: Andrea Aliverti; Peter T Macklem
The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(2):749-51; discussion 755-7.
2008: Peter T Macklem; Charles G Irvin
Dividing the FEV1 into its component parts.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(1):392; author reply 393.
2008: Peter T Macklem
Emergent phenomena and the secrets of life.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;104(6):1844-6.
2008: Peter T Macklem
At Last! A Realistic Animal Model of Severe Asthma.
American journal of respiratory and critical care medicine 2008;177(3):245-6.
2008: Isabelle Cossette; Pierpaolo Monaco; Andrea Aliverti; Peter T Macklem
Chest wall dynamics and muscle recruitment during professional flute playing.
Respiratory physiology & neurobiology 2008;160(2):187-95.
2007: Peter T Macklem
Canada's contribution to respiratory physiology and pathophysiology.
Canadian respiratory journal : journal of the Canadian Thoracic Society 2007;14(7):383-92.
2007: Henry E Fessler; Peter T Macklem
Percolation and phase transitions.
American journal of respiratory and critical care medicine 2007;176(6):530-1.
2007: Andrea Aliverti; Bengt Kayser; Peter T Macklem
A human model of the pathophysiology of chronic obstructive pulmonary disease.
Respirology (Carlton, Vic.) 2007;12(4):478-85.
2007: Cliff K Choong; Peter T Macklem; John A Pierce; Stephen S Lefrak; Jason C Woods; Mark S Conradi; Dmitriy A Yablonskiy; James C Hogg; Kimiaki Chino; Joel D Cooper
Transpleural ventilation of explanted human lungs.
Thorax 2007;62(7):623-30.
2007: Peter T Macklem
Bronchial thermoplasty.
The New England journal of medicine 2007;356(26):2744; author reply 2745.
2007: Ioannis Vogiatzis; Spyros Zakynthinos; Olga Georgiadou; Spyretta Golemati; Antonio Pedotti; Peter T Macklem; Charis Roussos; Andrea Aliverti
Oxygen kinetics and debt during recovery from expiratory flow-limited exercise in healthy humans.
European journal of applied physiology 2007;99(3):265-74.
2006: Jason C Woods; Cliff K Choong; Dmitriy A Yablonskiy; John Bentley; Jonathan Wong; John A Pierce; Joel D Cooper; Peter T Macklem; Mark S Conradi; James C Hogg
Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;56(6):1293-300.
2005: Jason C Woods; Dmitriy A Yablonskiy; Cliff K Choong; Kimiaki Chino; John A Pierce; James C Hogg; John Bentley; Joel D Cooper; Mark S Conradi; Peter T Macklem
Long-range diffusion of hyperpolarized 3He in explanted normal and emphysematous human lungs via magnetization tagging.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;99(5):1992-7.
2005: Andrea Aliverti; Raffaele L Dellacà; Pamela Lotti; S Bertini; Roberto Duranti; Giorgio Scano; J Heyman; A Lo Mauro; Antonio Pedotti; Peter T Macklem
Influence of expiratory flow-limitation during exercise on systemic oxygen delivery in humans.
European journal of applied physiology 2005;95(2-3):229-42.
2004: Andrew J E Seely; Peter T Macklem
Complex systems and the technology of variability analysis.
Critical care (London, England) 2004;8(6):R367-84.
2004: Peter T Macklem
Cell and molecular biology is not the only way to a better understanding of pathogenesis of lung disease.
American journal of respiratory and critical care medicine 2004;170(1):ii-iii; author reply iv.
2004: Peter T Macklem
A century of the mechanics of breathing.
American journal of respiratory and critical care medicine 2004;170(1):10-5.
2004: Andrea Aliverti; Bengt Kayser; Peter T Macklem
Breath-by-breath assessment of alveolar gas stores and exchange.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(4):1464-9.
2004: Peter T Macklem
Con: Greater funding of cell and molecular biology has not delivered what was promised to respiratory medicine.
American journal of respiratory and critical care medicine 2004;169(4):438-9; discussion 439-40.
2004: Raffaele L Dellacà; Pierachille Santus; Andrea Aliverti; Nicola J Stevenson; Stefano Centanni; Peter T Macklem; Antonio Pedotti; P M A Calverley
Detection of expiratory flow limitation in COPD using the forced oscillation technique.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;23(2):232-40.
2003: Peter T Macklem
The molecular-clinical divorce.
American journal of respiratory and critical care medicine 2003;168(4):500.
2003: Riccardo Pellegrino; Raffaele Dellaca; Peter T Macklem; Andrea Aliverti; Stefania Bertini; Pamela Lotti; PierGiuseppe Agostoni; Alessandro Locatelli; Vito Brusasco
Effects of rapid saline infusion on lung mechanics and airway responsiveness in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(2):728-34.
2003: Brent E McParland; Peter T Macklem; Peter D Pare
Airway wall remodeling: friend or foe?
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(1):426-34.
2003: Peter T Macklem
Is cell and molecular biology divorcing from clinical practice?
American journal of respiratory and critical care medicine 2003;167(9):1164-5.
2003: Andrea Aliverti; G Ghidoli; Raffaele L Dellacà; Antonio Pedotti; Peter T Macklem
Chest wall kinematic determinants of diaphragm length by optoelectronic plethysmography and ultrasonography.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;94(2):621-30.
2002: Cheng-Li Que; Christof Kolmaga; Louis-Gilles Durand; Suzanne M Kelly; Peter T Macklem
Phonospirometry for noninvasive measurement of ventilation: methodology and preliminary results.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(4):1515-26.
2002: Andrea Aliverti; Iacopo Iandelli; Roberto Duranti; Stephen J Cala; Bengt Kayser; Susan Kelly; Gianni Misuri; Antonio Pedotti; Giorgio Scano; Pawel Sliwinski; Sheng Yan; Peter T Macklem
Respiratory muscle dynamics and control during exercise with externally imposed expiratory flow limitation.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(5):1953-63.
2002: Iacopo Iandelli; Andrea Aliverti; Bengt Kayser; Raffaele L Dellacà; Stephen J Cala; Roberto Duranti; Susan Kelly; Giorgio Scano; Pawel Sliwinski; Sheng Yan; Peter T Macklem; Antonio Pedotti
Determinants of exercise performance in normal men with externally imposed expiratory flow limitation.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(5):1943-52.
2001: Cheng-Li Que; CM Kenyon; Ron Olivenstein; Peter T Macklem; GN Maksym
Homeokinesis and short-term variability of human airway caliber.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(3):1131-41.
2001: Andrea Aliverti; Peter T Macklem
How and why exercise is impaired in COPD.
Respiration; international review of thoracic diseases 2001;68(3):229-39.
2000: I Cossette; Pawel Sliwinski; Peter T Macklem
Respiratory parameters during professional flute playing.
Respiration physiology 2000;121(1):33-44.
2000: Cheng-Li Que; GN Maksym; Peter T Macklem
Deciphering the homeokinetic code of airway smooth muscle.
American journal of respiratory and critical care medicine 2000;161(3 Pt 2):S161-3.
2000: R Chen; Bengt Kayser; Sheng Yan; Peter T Macklem
Twitch transdiaphragmatic pressure depends critically on thoracoabdominal configuration.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(1):54-60.
1999: S Johnston; Sheng Yan; Pawel Sliwinski; Peter T Macklem
Modified Campbell diagram to assess respiratory muscle action in speech.
Respirology (Carlton, Vic.) 1999;4(3):213-22.
1999: J Suzuki; R Tanaka; Sheng Yan; R Chen; Peter T Macklem; Bengt Kayser
Assessment of abdominal muscle contractility, strength, and fatigue.
American journal of respiratory and critical care medicine 1999;159(4 Pt 1):1052-60.
1998: Peter T Macklem
New methods of imaging the respiratory system.
Respirology (Carlton, Vic.) 1998;3(2):101-2.
1998: Peter T Macklem
The physiology of small airways.
American journal of respiratory and critical care medicine 1998;157(5 Pt 2):S181-3.
1998: Peter T Macklem
The mechanics of breathing.
American journal of respiratory and critical care medicine 1998;157(4 Pt 2):S88-94.
1998: Stephen J Cala; CM Kenyon; A Lee; Lloyd Kenneth Watkin; Peter T Macklem; D F Rochester
Respiratory ultrasonography of human parasternal intercostal muscle in vivo.
Ultrasound in medicine & biology 1998;24(3):313-26.
1998: Peter T Macklem
Relationship between airway smooth muscle dysfunction and airway inflammation in asthma.
Canadian respiratory journal : journal of the Canadian Thoracic Society 1998;5(1):40.
1997: S M Kelly; Y L Jia; Peter T Macklem
Measurement of elastic properties of Xenopus oocytes.
Comparative biochemistry and physiology. Part A, Physiology 1997;118(3):607-13.
1997: Andrea Aliverti; Stephen J Cala; Roberto Duranti; Giancarlo Ferrigno; CM Kenyon; Antonio Pedotti; Giorgio Scano; Pawel Sliwinski; Peter T Macklem; Sheng Yan
Human respiratory muscle actions and control during exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;83(4):1256-69.
1997: CM Kenyon; Stephen J Cala; Sheng Yan; Andrea Aliverti; Giorgio Scano; Roberto Duranti; Antonio Pedotti; Peter T Macklem
Rib cage mechanics during quiet breathing and exercise in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;83(4):1242-55.
1997: Bengt Kayser; Pawel Sliwinski; Sheng Yan; M Tobiasz; Peter T Macklem
Respiratory effort sensation during exercise with induced expiratory-flow limitation in healthy humans.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;83(3):936-47.
1997: Pawel Sliwinski; Peter T Macklem
Inspiratory muscle dysfunction as a cause of death in COPD patients.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 1997;52(4):380-3.
1996: Stephen J Cala; CM Kenyon; Giancarlo Ferrigno; P Carnevali; Andrea Aliverti; Antonio Pedotti; Peter T Macklem; D F Rochester
Chest wall and lung volume estimation by optical reflectance motion analysis.
Journal of applied physiology (Bethesda, Md. : 1985) 1996;81(6):2680-9.
1996: Sheng Yan; Pawel Sliwinski; Peter T Macklem
Association of chest wall motion and tidal volume responses during CO2 rebreathing.
Journal of applied physiology (Bethesda, Md. : 1985) 1996;81(4):1528-34.
1996: K Chihara; CM Kenyon; Peter T Macklem
Human rib cage distortability.
Journal of applied physiology (Bethesda, Md. : 1985) 1996;81(1):437-47.
1996: P Sliwiński; Sheng Yan; A P Gauthier; Peter T Macklem
Influence of global inspiratory muscle fatigue on breathing during exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1996;80(4):1270-8.
1996: Katherine Gray-Donald; L Gibbons; S H Shapiro; Peter T Macklem; James G Martin
Nutritional status and mortality in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 1996;153(3):961-6.
1996: W J Gibbons; A Sharma; D Lougheed; Peter T Macklem
Detection of excessive bronchoconstriction in asthma.
American journal of respiratory and critical care medicine 1996;153(2):582-9.
1996: P Sliwiński; Sheng Yan; A P Gauthier; Peter T Macklem
[Effect of respiratory muscle fatigue on their function during exercise].
Pneumonologia i alergologia polska 1996;64(9-10):590-603.
1996: P Sliwiński; Sheng Yan; A P Gauthier; Peter T Macklem
[Function of the diaphragm during exercise].
Pneumonologia i alergologia polska 1996;64(9-10):577-89.
1996: M Yanai; CM Kenyon; J P Butler; Peter T Macklem; S M Kelly
Intracellular pressure is a motive force for cell motion in Amoeba proteus.
Cell motility and the cytoskeleton 1996;33(1):22-9.
1995: A P Gauthier; Sheng Yan; Pawel Sliwinski; Peter T Macklem
Effects of fatigue, fiber length, and aminophylline on human diaphragm contractility.
American journal of respiratory and critical care medicine 1995;152(1):204-10.
1995: Peter T Macklem
Theoretical basis of airway instability. Roger S. Mitchell Lecture.
Chest 1995;107(3 Suppl):87S-88S.
1994: A P Gauthier; Sylvia Verbanck; Marc Estenne; C Segebarth; Peter T Macklem; Manuel Paiva
Three-dimensional reconstruction of the in vivo human diaphragm shape at different lung volumes.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(2):495-506.
1993: Sheng Yan; Peter T Macklem
Effect of diaphragmatic and global inspiratory muscle fatigue on chemical control of breathing.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 1993;48(5):386-8.
1993: Sheng Yan; Pawel Sliwinski; A P Gauthier; I Lichros; S Zakynthinos; Peter T Macklem
Effect of global inspiratory muscle fatigue on ventilatory and respiratory muscle responses to CO2.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(3):1371-7.
1993: Sheng Yan; I Lichros; S Zakynthinos; Peter T Macklem
Effect of diaphragmatic fatigue on control of respiratory muscles and ventilation during CO2 rebreathing.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(3):1364-70.
1993: S J Johnston; Lloyd Kenneth Watkin; Peter T Macklem
Lung volume changes during relatively fluent speech in stutterers.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(2):696-703.
1993: T Similowski; A P Gauthier; Sheng Yan; Peter T Macklem; François Bellemare
Assessment of diaphragm function using mouth pressure twitches in chronic obstructive pulmonary disease patients.
The American review of respiratory disease 1993;147(4):850-6.
1993: Sheng Yan; A P Gauthier; T Similowski; R Faltus; Peter T Macklem; François Bellemare
Force-frequency relationships of in vivo human and in vitro rat diaphragm using paired stimuli.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(2):211-8.
1993: A P Gauthier; R E Faltus; Peter T Macklem; François Bellemare
Effects of fatigue on the length-tetanic force relationship of the rat diaphragm.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(1):326-32.
1992: S H Shapiro; P Ernst; Katherine Gray-Donald; James G Martin; Sharon Wood-Dauphinee; A Beaupré; W O Spitzer; Peter T Macklem
Effect of negative pressure ventilation in severe chronic obstructive pulmonary disease.
Lancet 1992;340(8833):1425-9.
1992: F M Robatto; S Simard; H Orana; Peter T Macklem; Mara S Ludwig
Effect of lung volume on plateau response of airways and tissue to methacholine in dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(5):1908-13.
1992: Sheng Yan; A P Gauthier; T Similowski; Peter T Macklem; François Bellemare
Evaluation of human diaphragm contractility using mouth pressure twitches.
The American review of respiratory disease 1992;145(5):1064-9.
1992: Manuel Paiva; Sylvia Verbanck; Marc Estenne; B Poncelet; C Segebarth; Peter T Macklem
Mechanical implications of in vivo human diaphragm shape.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(4):1407-12.
1992: Michael E Ward; J W Ward; Peter T Macklem
Analysis of human chest wall motion using a two-compartment rib cage model.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(4):1338-47.
1992: Sheng Yan; T Similowski; A P Gauthier; Peter T Macklem; François Bellemare
Effect of fatigue on diaphragmatic function at different lung volumes.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(3):1064-7.
1992: Michael E Ward; Manuel Paiva; Peter T Macklem
Vector analysis in partitioning of inspiratory muscle action in dogs.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1992;5(2):219-27.
1991: T Similowski; Sheng Yan; A P Gauthier; Peter T Macklem; François Bellemare
Contractile properties of the human diaphragm during chronic hyperinflation.
The New England journal of medicine 1991;325(13):917-23.
1991: Peter T Macklem
Factors determining bronchial smooth muscle shortening.
The American review of respiratory disease 1991;143(3 Pt 2):S47-8.
1991: S H Shapiro; Peter T Macklem; Katherine Gray-Donald; James G Martin; P P Ernst; Sharon Wood-Dauphinee; T A Hutchinson; W O Spitzer
A randomized clinical trial of negative pressure ventilation in severe chronic obstructive pulmonary disease: design and methods.
Journal of clinical epidemiology 1991;44(6):483-96.
1990: M Ward; Peter T Macklem
The act of breathing and how it fails.
Chest 1990;97(3 Suppl):36S-39S.
1990: Peter T Macklem; David H Eidelman
Reexamination of the elastic properties of emphysematous lungs.
Respiration; international review of thoracic diseases 1990;57(3):187-92.
1989: Peter T Macklem
Mechanical factors determining maximum bronchoconstriction.
The European respiratory journal. Supplement 1989;6():516s-519s.
1989: Salvatore Bellofiore; David H Eidelman; Peter T Macklem; James G Martin
Effects of elastase-induced emphysema on airway responsiveness to methacholine in rats.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(2):606-12.
1988: Michael E Ward; David H Eidelman; D G Stubbing; François Bellemare; Peter T Macklem
Respiratory sensation and pattern of respiratory muscle activation during diaphragm fatigue.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(5):2181-9.
1988: P D Sly; K A Brown; Jason H T Bates; Peter T Macklem; Joseph Milic-Emili; James G Martin
Effect of lung volume on interrupter resistance in cats challenged with methacholine.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;64(1):360-6.
1975: J Dosman; F Bode; J Urbanetti; R Martin; Peter T Macklem
The Use of a Helium-Oxygen Mixture during Maximum Expiratory Flow to Demonstrate Obstruction in Small Airways in Smokers.
The Journal of clinical investigation 1975;55(5):1090-9.
1968: J Holland; Joseph Milic-Emili; Peter T Macklem; D V Bates
Regional distribution of pulmonary ventilation and perfusion in elderly subjects.
The Journal of clinical investigation 1968;47(1):81-92.