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Margaret MacLean

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Loredana Ciuclan; Ieuan Clay; Nicholas Duggan; Roy Fox; Robert Good; Martin J Hussey; Gabor Jarai; Peter Jones; Irena Konstantinova; Margaret R MacLean; Andrew Pearce; David J Rowlands; Sarah Beach; Olivier Bonneau; Victoria Burton; John Westwick; Matthew Thomas
Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.
Kevin White; Annabel Campbell; Loredana Ciuclan; Anne Katrine Johansen; Lynn Loughlin; Kirsty M Mair; John D McClure; Ian Morecroft; Margaret Nilsen; Leigh Paton; Matthew Thomas; Emma Wallace; Margaret R MacLean
Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension.
Ian Morecroft; Margaret Nilsen; Paul N Reynolds; Katie White; Raul Alba; Andrew H Baker; Paola Caruso; Sergei M Danilov; Lynn Loughlin; Margaret R MacLean
Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.

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All Publications

2013: Loredana Ciuclan; Ieuan Clay; Nicholas Duggan; Roy Fox; Robert Good; Martin J Hussey; Gabor Jarai; Peter Jones; Irena Konstantinova; Margaret R MacLean; Andrew Pearce; David J Rowlands; Sarah Beach; Olivier Bonneau; Victoria Burton; John Westwick; Matthew Thomas
Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.
American journal of respiratory and critical care medicine 2013;187(1):78-89.
2012: Kevin White; Annabel Campbell; Loredana Ciuclan; Anne Katrine Johansen; Lynn Loughlin; Kirsty M Mair; John D McClure; Ian Morecroft; Margaret Nilsen; Leigh Paton; Matthew Thomas; Emma Wallace; Margaret R MacLean
Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension.
Circulation 2012;126(9):1087-98.
2012: Ian Morecroft; Margaret Nilsen; Paul N Reynolds; Katie White; Raul Alba; Andrew H Baker; Paola Caruso; Sergei M Danilov; Lynn Loughlin; Margaret R MacLean
Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(8):1516-28.
2012: Paola Caruso; Yvonne Dempsie; Lu Long; Ruifang Lu; Margaret R MacLean; Kirsty M Mair; John D McClure; Robert A McDonald; Nicholas W Morrell; Eric N Olson; Mark Southwood; Hannah C Stevens; Paul Upton; Eva van Rooij; Kevin White; Mei Xin; Andrew H Baker
A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples.
Circulation research 2012;111(3):290-300.
2012: Robert A McDonald; Nicholas W Morrell; Akiko Hata; Margaret R MacLean; Andrew H Baker
MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling.
Cardiovascular research 2012;93(4):594-604.
2011: Kevin White; Yvonne Dempsie; Margaret Nilsen; Audrey F Wright; Lynn Loughlin; Margaret R MacLean
The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension.
Cardiovascular research 2011;90(2):373-82.
2011: Kevin White; Lynn Loughlin; Zakia Maqbool; Margaret Nilsen; John McClure; Yvonne Dempsie; Andrew H Baker; Margaret R MacLean
Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH.
Physiological genomics 2011;43(8):417-37.
2011: Yvonne Dempsie; Lynn Loughlin; Noona Ambartsumian; Kirsty M Mair; Margaret Nilsen; Marlene Rabinovitch; Kevin White; Margaret R MacLean
Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females.
Respiratory research 2011;12():159.
2010: Paola Caruso; Margaret R MacLean; Raya Khanin; John McClure; Elaine Soon; Mark Southgate; Robert A MacDonald; Jenny A Greig; Keith E Robertson; Rachel Masson; Laura Denby; Yvonne Dempsie; Lu Long; Nicholas W Morrell; Andrew H Baker
Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(4):716-23.
2010: Ian Morecroft; Louisa Pang; Marta Baranowska; Margaret Nilsen; Lynn Loughlin; Yvonne Dempsie; Caroline Millet; Margaret R MacLean
In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
Cardiovascular research 2010;85(3):593-603.
2010: Margaret R MacLean; Yvonne Dempsie
The serotonin hypothesis of pulmonary hypertension revisited.
Advances in experimental medicine and biology 2010;661():309-22.
2009: Nicholas W Morrell; Serge Adnot; Stephen L Archer; Jocelyn Dupuis; Peter Lloyd Jones; Margaret R MacLean; Ivan F McMurtry; Kurt R Stenmark; Patricia A Thistlethwaite; Norbert Weissmann; Jason X-J Yuan; E Kenneth Weir
Cellular and molecular basis of pulmonary arterial hypertension.
Journal of the American College of Cardiology 2009;54(1 Suppl):S20-31.
2009: Margaret R MacLean; Yvonne Dempsie
Serotonin and pulmonary hypertension--from bench to bedside?
Current opinion in pharmacology 2009;9(3):281-6.
2008: K M Mair; Margaret R MacLean; Ian Morecroft; Yvonne Dempsie; Timothy Palmer
Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts.
British journal of pharmacology 2008;155(4):606-16.
2008: Yvonne Dempsie; Margaret R MacLean
Pulmonary hypertension: therapeutic targets within the serotonin system.
British journal of pharmacology 2008;155(4):455-62.
2008: Yvonne Dempsie; Ian Morecroft; David J Welsh; Neil A MacRitchie; Nigel Herold; Lynn Loughlin; Margaret Nilsen; Andrew J Peacock; Anthony J Harmar; Michael Bader; Margaret R MacLean
Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice.
Circulation 2008;117(22):2928-37.
2007: Margaret R MacLean
Pulmonary hypertension and the serotonin hypothesis: where are we now?
International journal of clinical practice. Supplement 2007;(156):27-31.
2007: Ian Morecroft; Yvonne Dempsie; Michael Bader; Diego J Walther; Katarina Kotnik; Lynn Loughlin; Margaret Nilsen; Margaret R MacLean
Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension.
Hypertension 2007;49(1):232-6.
2006: Jennifer Millen; Margaret R MacLean; Miles D Houslay
Hypoxia-induced remodelling of PDE4 isoform expression and cAMP handling in human pulmonary artery smooth muscle cells.
European journal of cell biology 2006;85(7):679-91.
2006: Graeme A Deuchar; Ian Morecroft; Yvonne Dempsie; Nigel Herold; Margaret Nilsen; Martin N Hicks; Margaret R MacLean
The in vivo effects of human urotensin II in the rabbit and rat pulmonary circulation: effects of experimental pulmonary hypertension.
European journal of pharmacology 2006;537(1-3):135-42.
2006: Lu Long; Margaret R MacLean; Trina K Jeffery; Ian Morecroft; Xudong Yang; Nung Rudarakanchana; Mark Southwood; Victoria James; Richard C Trembath; Nicholas W Morrell
Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice.
Circulation research 2006;98(6):818-27.
2005: Ian Morecroft; Lynn Loughlin; Margaret Nilsen; Janet Colston; Yvonne Dempsie; John Sheward; Anthony J Harmar; Margaret R MacLean
Functional interactions between 5-hydroxytryptamine receptors and the serotonin transporter in pulmonary arteries.
The Journal of pharmacology and experimental therapeutics 2005;313(2):539-48.
2005: Graeme A Deuchar; Martin N Hicks; Margaret R MacLean
The role of 5-hydroxytryptamine in the control of pulmonary vascular tone in a rabbit model of pulmonary hypertension secondary to left ventricular dysfunction.
Pulmonary pharmacology & therapeutics 2005;18(1):23-31.
2004: Marc Humbert; Nicholas W Morrell; Stephen L Archer; Kurt R Stenmark; Margaret R MacLean; Irene M Lang; Brian W Christman; E Kenneth Weir; Oliver Eickelberg; Norbert F Voelkel; Marlene Rabinovitch
Cellular and molecular pathobiology of pulmonary arterial hypertension.
Journal of the American College of Cardiology 2004;43(12 Suppl S):13S-24S.
2004: Margaret R MacLean; Graeme A Deuchar; Martin N Hicks; Ian Morecroft; Sanbing Shen; John Sheward; Janet Colston; Lynn Loughlin; Margaret Nilsen; Yvonne Dempsie; Anthony J Harmar
Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.
Circulation 2004;109(17):2150-5.
2003: R Murdoch; Ian Morecroft; Margaret R MacLean
5-HT moduline: an endogenous inhibitor of 5-HT(1B/1D)-mediated contraction in pulmonary arteries.
British journal of pharmacology 2003;138(5):795-800.
2002: William Mullen; Jennifer McGinn; M E J Lean; Margaret R MacLean; Peter Gardner; Garry G Duthie; Takoa Yokota; Alan Crozier
Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties.
Journal of agricultural and food chemistry 2002;50(18):5191-6.
2002: Graeme A Deuchar; Andrew Docherty; Margaret R MacLean; Martin N Hicks
Pulmonary hypertension secondary to left ventricular dysfunction: the role of nitric oxide and endothelin-1 in the control of pulmonary vascular tone.
British journal of pharmacology 2002;135(4):1060-8.
2001: A Keegan; Ian Morecroft; D Smillie; Martin N Hicks; Margaret R MacLean
Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935.
Circulation research 2001;89(12):1231-9.
2001: Margaret R MacLean; Ian Morecroft
Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy.
British journal of pharmacology 2001;134(3):614-20.
2001: Alison Stirrat; M Gallagher; Stephen Douglas; Eliot ohlstein; C Berry; Alison Kirk; M Richardson; Margaret R MacLean
Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries.
American journal of physiology. Heart and circulatory physiology 2001;280(2):H925-8.
2000: Margaret R MacLean; Philippe Herve; Saadia Eddahibi; S Adnot
5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension.
British journal of pharmacology 2000;131(2):161-8.
2000: Margaret R MacLean; D Alexander; Alison Stirrat; M Gallagher; Stephen Douglas; Eliot ohlstein; Ian Morecroft; KE Polland
Contractile responses to human urotensin-II in rat and human pulmonary arteries: effect of endothelial factors and chronic hypoxia in the rat.
British journal of pharmacology 2000;130(2):201-4.
2000: Ian Mullaney; D M Vaughan; Margaret R MacLean
Regional modulation of cyclic nucleotides by endothelin-1 in rat pulmonary arteries: direct activation of G(i)2-protein in the main pulmonary artery.
British journal of pharmacology 2000;129(5):1042-8.
2000: Jennifer Burns; Peter T Gardner; J O'Neil; S Crawford; Ian Morecroft; Donald B McPhail; C Lister; D Matthews; Margaret R MacLean; M E J Lean; Garry G Duthie; Alan Crozier
Relationship among antioxidant activity, vasodilation capacity, and phenolic content of red wines.
Journal of agricultural and food chemistry 2000;48(2):220-30.
1999: Margaret R MacLean
Pulmonary hypertension, anorexigens and 5-HT: pharmacological synergism in action?
Trends in pharmacological sciences 1999;20(12):490-5.
1999: Rob A Clayton; JE Nally; Margaret R MacLean; Neil C Thomson; John C McGrath
Chronic exposure to hypoxia attenuates contractile responses in rat airways in vitro: a possible role for nitric oxide.
European journal of pharmacology 1999;385(1):29-37.
1999: Ian Morecroft; R P Heeley; HM Prentice; Alison Kirk; Margaret R MacLean
5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor.
British journal of pharmacology 1999;128(3):730-4.
1999: Peter J Cowburn; John G F Cleland; John D McArthur; Margaret R MacLean; john mcmurray; Henry J Dargie; James J Morton
Endothelin B receptors are functionally important in mediating vasoconstriction in the systemic circulation in patients with left ventricular systolic dysfunction.
Journal of the American College of Cardiology 1999;33(4):932-8.
1999: Rob A Clayton; JE Nally; Margaret R MacLean; Neil C Thomson; John C McGrath
The effect of chronic hypoxia on endothelin receptor subtype-mediated responses in rat isolated airways.
Pulmonary pharmacology & therapeutics 1999;12(3):203-13.
1998: Ian Morecroft; Margaret R MacLean
Developmental changes in endothelium-dependent vasodilation and the influence of superoxide anions in perinatal rabbit pulmonary arteries.
British journal of pharmacology 1998;125(7):1585-93.
1998: Peter J Cowburn; John G F Cleland; John D McArthur; Margaret R MacLean; Henry J Dargie; john mcmurray; James J Morton
Endothelin-1 has haemodynamic effects at pathophysiological concentrations in patients with left ventricular dysfunction.
Cardiovascular research 1998;39(3):563-70.
1998: Ian Morecroft; Margaret R MacLean
5-hydroxytryptamine receptors mediating vasoconstriction and vasodilation in perinatal and adult rabbit small pulmonary arteries.
British journal of pharmacology 1998;125(1):69-78.
1998: Peter J Cowburn; John G F Cleland; John D McArthur; Margaret R MacLean; john mcmurray; Henry J Dargie
Short-term haemodynamic effects of BQ-123, a selective endothelin ET(A)-receptor antagonist, in chronic heart failure.
Lancet 1998;352(9123):201-2.
1998: CC Docherty; Margaret R MacLean
Development of endothelin receptors in perinatal rabbit pulmonary resistance arteries.
British journal of pharmacology 1998;124(6):1165-74.
1998: Graeme A Deuchar; Martin N Hicks; Stuart M Cobbe; CC Docherty; Margaret R MacLean
Pulmonary responses to 5-hydroxytryptamine and endothelin-1 in a rabbit model of left ventricular dysfunction.
Cardiovascular research 1998;38(2):500-7.
1998: Margaret R MacLean; CC Docherty; KM Mcculloch; Ian Morecroft
Effect of novel mixed ETA/ETB antagonists on responses to ET-1 in human small muscular pulmonary arteries.
Pulmonary pharmacology & therapeutics 1998;11(2-3):147-9.
1998: Margaret R MacLean
Endothelin-1: a mediator of pulmonary hypertension?
Pulmonary pharmacology & therapeutics 1998;11(2-3):125-32.
1998: KM Mcculloch; CC Docherty; Margaret R MacLean
Endothelin receptors mediating contraction of rat and human pulmonary resistance arteries: effect of chronic hypoxia in the rat.
British journal of pharmacology 1998;123(8):1621-30.
1998: Margaret R MacLean; KM Mcculloch
Influence of applied tension and nitric oxide on responses to endothelins in rat pulmonary resistance arteries: effect of chronic hypoxia.
British journal of pharmacology 1998;123(5):991-9.
1998: CC Docherty; Margaret R MacLean
EndothelinB receptors in rabbit pulmonary resistance arteries: effect of left ventricular dysfunction.
The Journal of pharmacology and experimental therapeutics 1998;284(3):895-903.
1998: Peter J Cowburn; John G F Cleland; John D McArthur; Margaret R MacLean; john mcmurray; Henry J Dargie
Pulmonary and systemic responses to exogenous endothelin-1 in patients with left ventricular dysfunction.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S290-3.
1998: Margaret R MacLean; JF Mackenzie; CC Docherty
Heterogeneity of endothelin-B receptors in rabbit pulmonary resistance arteries.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S115-8.
1997: Margaret R MacLean; E D Johnston; KM Mcculloch; L Pooley; Miles D Houslay; G Sweeney
Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension.
The Journal of pharmacology and experimental therapeutics 1997;283(2):619-24.
1996: KM Mcculloch; CC Docherty; Ian Morecroft; Margaret R MacLean
EndothelinB receptor-mediated contraction in human pulmonary resistance arteries.
British journal of pharmacology 1996;119(6):1125-30.
1996: Margaret R MacLean; G Sweeney; M Baird; KM Mcculloch; Miles D Houslay; Ian Morecroft
5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats.
British journal of pharmacology 1996;119(5):917-30.
1996: Margaret R MacLean; Rob A Clayton; A G Templeton; Ian Morecroft
Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery.
British journal of pharmacology 1996;119(2):277-82.
1996: V S Karamsetty; Margaret R MacLean; KM Mcculloch; Kathleen A Kane; Roger M Wadsworth
Hypoxic constrictor response in the isolated pulmonary artery from chronically hypoxic rats.
Respiration physiology 1996;105(1-2):85-93.
1995: Margaret R MacLean; KM Mcculloch; M Baird
Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries.
Journal of cardiovascular pharmacology 1995;26(5):822-30.
1995: G Sweeney; A Templeton; Rob A Clayton; M Baird; S Sheridan; E D Johnston; Margaret R MacLean
Contractile responses to sumatriptan in isolated bovine pulmonary artery rings: relationship to tone and cyclic nucleotide levels.
Journal of cardiovascular pharmacology 1995;26(5):751-60.
1995: KM Mcculloch; Margaret R MacLean
EndothelinB receptor-mediated contraction of human and rat pulmonary resistance arteries and the effect of pulmonary hypertension on endothelin responses in the rat.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S169-76.
1994: Margaret R MacLean; KM Mcculloch; M Baird
Endothelin ETA- and ETB-receptor-mediated vasoconstriction in rat pulmonary arteries and arterioles.
Journal of cardiovascular pharmacology 1994;23(5):838-45.
1994: Margaret R MacLean; Rob A Clayton; S W Hillis; P D McIntyre; A J Peacock; A G Templeton
5-HT1-receptor-mediated vasoconstriction in bovine isolated pulmonary arteries: influences of vascular endothelium and tone.
Pulmonary pharmacology 1994;7(1):65-72.
1994: Margaret R MacLean; J Graham; John C McGrath
Endogenous nitric oxide modulates vasopressor responses, but not depressor responses, to spinal sympathetic nerve stimulation in pithed rats.
Journal of cardiovascular pharmacology 1994;23(2):319-25.
1993: Margaret R MacLean; G C Smith; A G Templeton
Adverse reactions associated with sumatriptan.
Lancet 1993;341(8852):1092.
1993: Margaret R MacLean; KM Mcculloch; John C McGrath
Influences of the endothelium and hypoxia on alpha 1- and alpha 2-adrenoceptor-mediated responses in the rabbit isolated pulmonary artery.
British journal of pharmacology 1993;108(1):155-61.
1993: Margaret R MacLean; KM Mcculloch; Joyce Macmillan; John C McGrath
Influences of the endothelium and hypoxia on neurogenic transmission in the isolated pulmonary artery of the rabbit.
British journal of pharmacology 1993;108(1):150-4.
1992: Margaret R MacLean; A G Templeton; John C McGrath
The influence of endothelin-1 on human foeto-placental blood vessels: a comparison with 5-hydroxytryptamine.
British journal of pharmacology 1992;106(4):937-41.
1990: Margaret R MacLean; John C McGrath
Effects of endothelin-1 on isolated vascular beds from normotensive and spontaneously hypertensive rats.
European journal of pharmacology 1990;190(1-2):263-7.
1990: Margaret R MacLean; John C McGrath
Effects of pre-contraction with endothelin-1 on alpha 2-adrenoceptor- and (endothelium-dependent) neuropeptide Y-mediated contractions in the isolated vascular bed of the rat tail.
British journal of pharmacology 1990;101(1):205-11.