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William MacNee

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
MacNee William; Tuder Rubin M
New paradigms in the pathogenesis of chronic obstructive pulmonary disease I.
Pinnock Hilary; Hanley Janet; Lewis Stephanie; MacNee William; Pagliari Claudia; van der Pol Marjon; Sheikh Aziz; McKinstry Brian;
The impact of a telemetric chronic obstructive pulmonary disease monitoring service: randomised controlled trial with economic evaluation and nested qualitative study.
Maclay John D; McAllister David A; Mills Nicholas L; Paterson Finny P; Ludlam Christopher A; Drost Ellen M; Newby David E; Macnee William
Vascular dysfunction in chronic obstructive pulmonary disease.

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All Publications

2009: MacNee William; Tuder Rubin M
New paradigms in the pathogenesis of chronic obstructive pulmonary disease I.
Proceedings of the American Thoracic Society 2009;6(6):527-31.
2009: Pinnock Hilary; Hanley Janet; Lewis Stephanie; MacNee William; Pagliari Claudia; van der Pol Marjon; Sheikh Aziz; McKinstry Brian;
The impact of a telemetric chronic obstructive pulmonary disease monitoring service: randomised controlled trial with economic evaluation and nested qualitative study.
Primary care respiratory journal : journal of the General Practice Airways Group 2009;18(3):233-5.
2009: Maclay John D; McAllister David A; Mills Nicholas L; Paterson Finny P; Ludlam Christopher A; Drost Ellen M; Newby David E; Macnee William
Vascular dysfunction in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2009;180(6):513-20.
2009: MacNee William
Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD).
Biochemical Society transactions 2009;37(Pt 4):819-23.
2009: Baillie J K; Thompson A A R; Irving J B; Bates M G D; Sutherland A I; Macnee W; Maxwell S R J; Webb D J
Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial.
QJM : monthly journal of the Association of Physicians 2009;102(5):341-8.
2009: Maclay John D; Rabinovich Roberto A; MacNee William
Update in chronic obstructive pulmonary disease 2008.
American journal of respiratory and critical care medicine 2009;179(7):533-41.
2009: Lu Senlin; Duffin Rodger; Poland Craig; Daly Paul; Murphy Fiona; Drost Ellen; Macnee William; Stone Vicki; Donaldson Ken
Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation.
Environmental health perspectives 2009;117(2):241-7.
2009: Schünemann Holger J; Woodhead Mark; Anzueto Antonio; Buist Sonia; Macnee William; Rabe Klaus F; Heffner John
A vision statement on guideline development for respiratory disease: the example of COPD.
Lancet 2009;373(9665):774-9.
2009: Behr Jürgen; Demedts Maurits; Buhl Roland; Costabel Ulrich; Dekhuijzen Richard P N; Jansen Henk M; MacNee William; Thomeer Michiel; Wallaert Benoit; Laurent Francois; Nicholson Andrew G; Verbeken Eric K; Verschakelen Johny; Flower C D R; Petruzzelli Stefano; De Vuyst Paul; van den Bosch J M M; Rodriguez-Becerra Eulogio; Lankhorst Ida; Sardina Marco; Boissard Gabrielle;
Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial.
Respiratory research 2009;10():101.
2009: Anderson David; Macnee William
Targeted treatment in COPD: a multi-system approach for a multi-system disease.
International journal of chronic obstructive pulmonary disease 2009;4(2):321-35.
2008: Macnee William; Maclay John; McAllister David
Cardiovascular injury and repair in chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2008;5(8):824-33.
2008: Poland Craig A; Duffin Rodger; Kinloch Ian; Maynard Andrew; Wallace William A H; Seaton Anthony; Stone Vicki; Brown Simon; Macnee William; Donaldson Ken
Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study.
Nature nanotechnology 2008;3(7):423-8.
2008: Mills Nicholas L; Robinson Simon D; Fokkens Paul H B; Leseman Daan L A C; Miller Mark R; Anderson David; Freney Evelyn J; Heal Mathew R; Donovan Robert J; Blomberg Anders; Sandström Thomas; MacNee William; Boon Nicholas A; Donaldson Ken; Newby David E; Cassee Flemming R
Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease.
Environmental health perspectives 2008;116(6):709-15.
2008: MacNee William
Update in chronic obstructive pulmonary disease 2007.
American journal of respiratory and critical care medicine 2008;177(8):820-9.
2008: Mills N L; Miller J J; Anand A; Robinson S D; Frazer G A; Anderson D; Breen L; Wilkinson I B; McEniery C M; Donaldson K; Newby D E; Macnee W
Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk.
Thorax 2008;63(4):306-11.
2008: Carder M; McNamee R; Beverland I; Elton R; Van Tongeren M; Cohen G R; Boyd J; Macnee W; Agius R M
Interacting effects of particulate pollution and cold temperature on cardiorespiratory mortality in Scotland.
Occupational and environmental medicine 2008;65(3):197-204.
2008: Mroz R M; Schins R P F; Li H; Jimenez L A; Drost E M; Holownia A; MacNee W; Donaldson K
Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(2):241-51.
2008: Bathoorn Erik; Kerstjens Huib; Postma Dirkje; Timens Wim; MacNee William
Airways inflammation and treatment during acute exacerbations of COPD.
International journal of chronic obstructive pulmonary disease 2008;3(2):217-29.
2007: McAllister David A; Maclay John D; Mills Nicholas L; Mair Grant; Miller Joy; Anderson David; Newby David E; Murchison John T; Macnee William
Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2007;176(12):1208-14.
2007: Mroz R M; Schins R P F; Li H; Drost E M; Macnee W; Donaldson K
Nanoparticle carbon black driven DNA damage induces growth arrest and AP-1 and NFkappaB DNA binding in lung epithelial A549 cell line.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2007;58 Suppl 5(Pt 2):461-70.
2007: Mroz R M; Holownia A; Chyczewska E; Drost E M; Braszko J J; Noparlik J; Donaldson K; Macnee W
Cytoplasm-nuclear trafficking of CREB and CREB phosphorylation at Ser133 during therapy of chronic obstructive pulmonary disease.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2007;58 Suppl 5(Pt 2):437-44.
2007: Chappell S; Daly L; Morgan K; Baranes T G; Roca J; Rabinovich R; Millar A; Donnelly S C; Keatings V; Macnee W; Stolk J; Hiemstra P S; Miniati M; Monti S; O'Connor C M; Kalsheker N
Variation in the tumour necrosis factor gene is not associated with susceptibility to COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;30(4):810-2.
2007: Maclay John D; McAllister David A; Macnee William
Cardiovascular risk in chronic obstructive pulmonary disease.
Respirology (Carlton, Vic.) 2007;12(5):634-41.
2007: Macnee William
Pathogenesis of chronic obstructive pulmonary disease.
Clinics in chest medicine 2007;28(3):479-513, v.
2007: Monteiller Claire; Tran Lang; MacNee William; Faux Steve; Jones Alan; Miller Brian; Donaldson Ken
The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area.
Occupational and environmental medicine 2007;64(9):609-15.
2007: Törnqvist Håkan; Mills Nicholas L; Gonzalez Manuel; Miller Mark R; Robinson Simon D; Megson Ian L; Macnee William; Donaldson Ken; Söderberg Stefan; Newby David E; Sandström Thomas; Blomberg Anders
Persistent endothelial dysfunction in humans after diesel exhaust inhalation.
American journal of respiratory and critical care medicine 2007;176(4):395-400.
2006: Morrison Douglas; Rahman Irfan; MacNee William
Permeability, inflammation and oxidant status in airspace epithelium exposed to ozone.
Respiratory medicine 2006;100(12):2227-34.
2006: Roghanian Ali; Drost Ellen M; MacNee William; Howie Sarah E M; Sallenave Jean-Michel
Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase.
American journal of respiratory and critical care medicine 2006;174(11):1189-98.
2006: Chappell Sally; Daly Leslie; Morgan Kevin; Baranes Tamar Guetta; Roca Josep; Rabinovich Roberto; Millar Ann; Donnelly Seamas C; Keatings Vera; MacNee William; Stolk Jan; Hiemstra Pieter S; Miniati Massimo; Monti Simonetta; O'Connor Clare M; Kalsheker Noor
The SERPINE2 gene and chronic obstructive pulmonary disease.
American journal of human genetics 2006;79(1):184-6; author reply 186-7.
2006: Szulakowski Patryk; Crowther Ann J L; Jiménez Luis A; Donaldson Kenneth; Mayer Ruth; Leonard Thomas B; MacNee William; Drost Ellen M
The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2006;174(1):41-50.
2006: Marwick John A; Stevenson Christopher S; Giddings June; MacNee William; Butler Keith; Rahman Irfan; Kirkham Paul A
Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition.
American journal of physiology. Lung cellular and molecular physiology 2006;290(5):L897-908.
2006: Morlá M; Busquets X; Pons J; Sauleda J; MacNee W; Agustí A G N
Telomere shortening in smokers with and without COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;27(3):525-8.
2006: Mills Nicholas L; Amin Nadia; Robinson Simon D; Anand Atul; Davies John; Patel Dilip; de la Fuente Jesus M; Cassee Flemming R; Boon Nicholas A; Macnee William; Millar Alistair M; Donaldson Ken; Newby David E
Do inhaled carbon nanoparticles translocate directly into the circulation in humans?
American journal of respiratory and critical care medicine 2006;173(4):426-31.
2006: Chappell Sally; Daly Leslie; Morgan Kevin; Guetta Baranes Tamar; Roca Josep; Rabinovich Roberto; Millar Ann; Donnelly Seamas C; Keatings Vera; MacNee William; Stolk Jan; Hiemstra Pieter; Miniati Massimo; Monti Simonetta; O'Connor Clare M; Kalsheker Noor
Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease.
Human mutation 2006;27(1):103-9.
2006: Szulakowski Patryk; Mróz Robert M; Pierzchala Wladyslaw; Chyczewska Elzbieta; MacNee William
[Pathogenesis of chronic obstructive pulmonary disease. Molecular mechanisms (part II)]
Wiadomosci lekarskie (Warsaw, Poland : 1960) 2006;59(3-4):250-4.
2006: Mróz Robert M; Szulakowski Patryk; Pierzchala Wliadyslaw; Chyczewska Elzbieta; MacNee William
[Pathogenesis of chronic obstructive pulmonary disease. Cellular mechanisms (part I)]
Wiadomosci lekarskie (Warsaw, Poland : 1960) 2006;59(1-2):92-6.
2005: MacNee William
Oxidants and COPD.
Current drug targets. Inflammation and allergy 2005;4(6):627-41.
2005: Mills Nicholas L; Törnqvist Håkan; Robinson Simon D; Gonzalez Manuel; Darnley Kareen; MacNee William; Boon Nicholas A; Donaldson Ken; Blomberg Anders; Sandstrom Thomas; Newby David E
Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis.
Circulation 2005;112(25):3930-6.
2005: Celli Bartolome R; Calverley Peter M A; Rennard Stephen I; Wouters Emiel F M; Agusti Alvar; Anthonisen Nicholas; Macnee William; Jones Paul; Pride Neil; Rodriguez-Roisin Roberto; Rossi Andrea; Wanner Adam
Proposal for a multidimensional staging system for chronic obstructive pulmonary disease.
Respiratory medicine 2005;99(12):1546-54.
2005: Demedts Maurits; Behr Juergen; Buhl Roland; Costabel Ulrich; Dekhuijzen Richard; Jansen Henk M; MacNee William; Thomeer Michiel; Wallaert Benoit; Laurent François; Nicholson Andrew G; Verbeken Eric K; Verschakelen Johny; Flower Christopher D R; Capron Frédérique; Petruzzelli Stefano; De Vuyst Paul; van den Bosch Jules M M; Rodriguez-Becerra Eulogio; Corvasce Giuseppina; Lankhorst Ida; Sardina Marco; Montanari Mauro;
High-dose acetylcysteine in idiopathic pulmonary fibrosis.
The New England journal of medicine 2005;353(21):2229-42.
2005: Donaldson Ken; Tran Lang; Jimenez Luis Albert; Duffin Rodger; Newby David E; Mills Nicholas; MacNee William; Stone Vicki
Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure.
Particle and fibre toxicology 2005;2():10.
2005: Macnee William
Prescription of oxygen: still problems after all these years.
American journal of respiratory and critical care medicine 2005;172(5):517-8.
2005: Donaldson Ken; Mills Nicholas; MacNee William; Robinson Simon; Newby David
Role of inflammation in cardiopulmonary health effects of PM.
Toxicology and applied pharmacology 2005;207(2 Suppl):483-8.
2005: McNeilly J D; Jiménez L A; Clay M F; MacNee W; Howe A; Heal M R; Beverland I J; Donaldson K
Soluble transition metals in welding fumes cause inflammation via activation of NF-kappaB and AP-1.
Toxicology letters 2005;158(2):152-7.
2005: Echazarreta Andrés L; Rahman Irfan; Peinado Victor; Barberà Joan Albert; Roca Josep; MacNee William; Rodríguez-Roisin Robert
Lack of systemic oxidative stress during PAF challenge in mild asthma.
Respiratory medicine 2005;99(5):519-23.
2005: Drost E M; Skwarski K M; Sauleda J; Soler N; Roca J; Agusti A; MacNee W
Oxidative stress and airway inflammation in severe exacerbations of COPD.
Thorax 2005;60(4):293-300.
2005: Fabbri Leonardo; Peters Stephen P; Pavord Ian; Wenzel Sally E; Lazarus Stephen C; Macnee William; Lemaire François; Abraham Edward
Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004.
American journal of respiratory and critical care medicine 2005;171(7):686-98.
2005: Bradley T Douglas; Miller York E; Martinez Fernando J; Angus Derek C; Macnee William; Abraham Edward
Interstitial lung disease, lung cancer, lung transplantation, pulmonary vascular disorders, and sleep-disordered breathing in AJRCCM in 2004.
American journal of respiratory and critical care medicine 2005;171(7):675-85.
2005: Nemery Benoit; Yew Wing Wai; Albert Rick; Brun-Buisson Christian; Macnee William; Martinez Fernando J; Angus Derek C; Abraham Edward
Tuberculosis, nontuberculous lung infection, pleural disorders, pulmonary function, respiratory muscles, occupational lung disease, pulmonary infections, and social issues in AJRCCM in 2004.
American journal of respiratory and critical care medicine 2005;171(6):554-62.
2005: Bush Andrew; Accurso Frank; Macnee William; Lazarus Stephen C; Abraham Edward
Cystic fibrosis, pediatrics, control of breathing, pulmonary physiology and anatomy, and surfactant biology in AJRCCM in 2004.
American journal of respiratory and critical care medicine 2005;171(6):545-53.
2005: Angus Derek; Ishizaka Akitoshi; Matthay Michael; Lemaire François; Macnee William; Abraham Edward
Critical care in AJRCCM 2004.
American journal of respiratory and critical care medicine 2005;171(6):537-44.
2005: Gilmour P S; Morrison E R; Vickers M A; Ford I; Ludlam C A; Greaves M; Donaldson K; MacNee W
The procoagulant potential of environmental particles (PM10).
Occupational and environmental medicine 2005;62(3):164-71.
2005: MacNee William
Pathogenesis of chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2005;2(4):258-66; discussion 290-1.
2005: MacNee William
Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2005;2(1):50-60.
2004: Chappell Sally; Guetta-Baranés Tamar; Batowski Kathryn; Yiannakis Eftihia; Morgan Kevin; O'Connor Clare; MacNee William; Kalsheker Noor
Haplotypes of the alpha-1 antitrypsin gene in healthy controls and Z deficiency patients.
Human mutation 2004;24(6):535-6.
2004: Marwick John A; Kirkham Paul A; Stevenson Christopher S; Danahay Henry; Giddings June; Butler Keith; Donaldson Kenneth; Macnee William; Rahman Irfan
Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.
American journal of respiratory cell and molecular biology 2004;31(6):633-42.
2004: MacNee William
Guidelines for chronic obstructive pulmonary disease.
BMJ (Clinical research ed.) 2004;329(7462):361-3.
2004: Antonicelli Frank; Brown David; Parmentier Maryline; Drost Ellen M; Hirani Nik; Rahman Irfan; Donaldson Ken; MacNee William
Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn.
American journal of physiology. Lung cellular and molecular physiology 2004;286(6):L1319-27.
2004: Noguera Aina; Sala Ernest; Pons Antonia R; Iglesias Julio; MacNee William; Agustí Alvar G N
Expression of adhesion molecules during apoptosis of circulating neutrophils in COPD.
Chest 2004;125(5):1837-42.
2004: McNeilly Jane D; Heal Mathew R; Beverland Iain J; Howe Alan; Gibson Mark D; Hibbs Leon R; MacNee William; Donaldson Ken
Soluble transition metals cause the pro-inflammatory effects of welding fumes in vitro.
Toxicology and applied pharmacology 2004;196(1):95-107.
2004: Gilmour Peter S; Ziesenis Axel; Morrison E Rona; Vickers Mark A; Drost Ellen M; Ford Isobel; Karg Erwin; Mossa Claudia; Schroeppel Andreas; Ferron George A; Heyder Joachim; Greaves Michael; MacNee William; Donaldson Kenneth
Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles.
Toxicology and applied pharmacology 2004;195(1):35-44.
2003: Wickenden Julie A; Clarke Murray C H; Rossi Adriano G; Rahman Irfan; Faux Stephen P; Donaldson Kenneth; MacNee William
Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis.
American journal of respiratory cell and molecular biology 2003;29(5):562-70.
2003: Donaldson Ken; Stone Vicki; Borm Paul J A; Jimenez Luis A; Gilmour Peter S; Schins Roel P F; Knaapen Ad M; Rahman Irfan; Faux Stephen P; Brown David M; MacNee William
Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10).
Free radical biology & medicine 2003;34(11):1369-82.
2003: MacNee W; Calverley P M A
Chronic obstructive pulmonary disease . 7: Management of COPD.
Thorax 2003;58(3):261-5.
2003: Gilmour Peter S; Rahman Irfan; Donaldson Kenneth; MacNee William
Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles.
American journal of physiology. Lung cellular and molecular physiology 2003;284(3):L533-40.
2003: Kim Huijung; Liu Xiangde; Kobayashi Tetsu; Kohyama Tadashi; Wen Fu-Qiang; Romberger Debra J; Conner Heather; Gilmour Peter S; Donaldson Kenneth; MacNee William; Rennard Stephen I
Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction.
American journal of respiratory cell and molecular biology 2003;28(1):111-21.
2002: Marwick John A; Kirkham Paul; Gilmour Peter S; Donaldson Kenneth; MacNEE William; Rahman Irfan
Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells.
Annals of the New York Academy of Sciences 2002;973():278-83.
2002: Rahman Irfan; van Schadewijk Annemarie A M; Crowther Ann J L; Hiemstra Pieter S; Stolk Jan; MacNee William; De Boer Willem I
4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2002;166(4):490-5.
2002: Kim Hui Jung; Liu Xiangde; Wang Hangjun; Kohyama Tadashi; Kobayashi Tetsu; Wen Fu-Qiang; Romberger Debra J; Abe Shinji; MacNee William; Rahman Irfan; Rennard Stephen I
Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke.
American journal of physiology. Lung cellular and molecular physiology 2002;283(2):L409-17.
2002: Jardine Hazel; MacNee William; Donaldson Kenneth; Rahman Irfan
Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1.
The Journal of biological chemistry 2002;277(24):21158-66.
2002: Rahman Irfan; Gilmour Peter S; Jimenez Luis Albert; MacNee William
Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation.
Molecular and cellular biochemistry 2002;234-235(1-2):239-48.
2002: Antonicelli Frank; Parmentier Maryline; Drost Ellen M; Hirani Nik; Rahman Irfan; Donaldson Ken; MacNee William
Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappaB nuclear binding in alveolar epithelial cells.
Free radical biology & medicine 2002;32(6):492-502.
2002: Drost Ellen M; MacNee William
Potential role of IL-8, platelet-activating factor and TNF-alpha in the sequestration of neutrophils in the lung: effects on neutrophil deformability, adhesion receptor expression, and chemotaxis.
European journal of immunology 2002;32(2):393-403.
2002: Jiménez L A; Drost E M; Gilmour P S; Rahman I; Antonicelli F; Ritchie H; MacNee W; Donaldson K
PM(10)-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-alpha.
American journal of physiology. Lung cellular and molecular physiology 2002;282(2):L237-48.
2002: Donaldson Ken; Brown David; Clouter Anna; Duffin Rodger; MacNee William; Renwick Louise; Tran Lang; Stone Vicki
The pulmonary toxicology of ultrafine particles.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2002;15(2):213-20.
2001: Duffin R; Gilmour P S; Schins R P; Clouter A; Guy K; Brown D M; MacNee W; Borm P J; Donaldson K; Stone V
Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression, and nuclear factor-kappaB activation.
Toxicology and applied pharmacology 2001;176(1):10-7.
2001: Brown D M; Wilson M R; MacNee W; Stone V; Donaldson K
Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines.
Toxicology and applied pharmacology 2001;175(3):191-9.
2001: Rahman I; Mulier B; Gilmour P S; Watchorn T; Donaldson K; Jeffery P K; MacNee W
Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB.
Biochemical pharmacology 2001;62(6):787-94.
2001: Gilmour P S; Rahman I; Hayashi S; Hogg J C; Donaldson K; MacNee W
Adenoviral E1A primes alveolar epithelial cells to PM(10)-induced transcription of interleukin-8.
American journal of physiology. Lung cellular and molecular physiology 2001;281(3):L598-606.
2001: Donaldson K; Stone V; Seaton A; MacNee W
Ambient particle inhalation and the cardiovascular system: potential mechanisms.
Environmental health perspectives 2001;109 Suppl 4():523-7.
2001: Noguera A; Batle S; Miralles C; Iglesias J; Busquets X; MacNee W; Agustí A G
Enhanced neutrophil response in chronic obstructive pulmonary disease.
Thorax 2001;56(6):432-7.
2001: Donaldson K; Stone V; Clouter A; Renwick L; MacNee W
Ultrafine particles.
Occupational and environmental medicine 2001;58(3):211-6, 199.
2000: Parmentier M; Hirani N; Rahman I; Donaldson K; MacNee W; Antonicelli F
Regulation of lipopolysaccharide-mediated interleukin-1beta release by N-acetylcysteine in THP-1 cells.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;16(5):933-9.
2000: Brown D M; Stone V; Findlay P; MacNee W; Donaldson K
Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components.
Occupational and environmental medicine 2000;57(10):685-91.
2000: Rahman I; MacNee W
Oxidative stress and regulation of glutathione in lung inflammation.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;16(3):534-54.
2000: Schins R P; McAlinden A; MacNee W; Jimenez L A; Ross J A; Guy K; Faux S P; Donaldson K
Persistent depletion of I kappa B alpha and interleukin-8 expression in human pulmonary epithelial cells exposed to quartz particles.
Toxicology and applied pharmacology 2000;167(2):107-17.
2000: Miralles C; Busquets X; Santos C; Togores B; Hussain S; Rahman I; MacNee W; Agustí A G
Regulation of iNOS expression and glutathione levels in rat liver by oxygen tension.
FEBS letters 2000;476(3):253-7.
2000: Jiménez L A; Thompson J; Brown D A; Rahman I; Antonicelli F; Duffin R; Drost E M; Hay R T; Donaldson K; MacNee W
Activation of NF-kappaB by PM(10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation.
Toxicology and applied pharmacology 2000;166(2):101-10.
2000: Rahman I; MacNee W
Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches.
Free radical biology & medicine 2000;28(9):1405-20.
2000: MacNee W; Donaldson K
Exacerbations of COPD: environmental mechanisms.
Chest 2000;117(5 Suppl 2):390S-7S.
2000: MacNee W
Oxidants/antioxidants and COPD.
Chest 2000;117(5 Suppl 1):303S-17S.
2000: Rahman I; van Schadewijk A A; Hiemstra P S; Stolk J; van Krieken J H; MacNee W; de Boer W I
Localization of gamma-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease.
Free radical biology & medicine 2000;28(6):920-5.
2000: Stone V; Tuinman M; Vamvakopoulos J E; Shaw J; Brown D; Petterson S; Faux S P; Borm P; MacNee W; Michaelangeli F; Donaldson K
Increased calcium influx in a monocytic cell line on exposure to ultrafine carbon black.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;15(2):297-303.
1999: Rahman I; MacNee W
Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease.
The American journal of physiology 1999;277(6 Pt 1):L1067-88.
1999: Macnee W; Rahman I
Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 1999;160(5 Pt 2):S58-65.
1999: Rahman I; Skwarska E; Henry M; Davis M; O'Connor C M; FitzGerald M X; Greening A; MacNee W
Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis.
Free radical biology & medicine 1999;27(1-2):60-8.
1999: Rahman I; Antonicelli F; MacNee W
Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-alpha and dexamethasone in human alveolar epithelial cells.
The Journal of biological chemistry 1999;274(8):5088-96.
1999: Morrison D; Rahman I; Lannan S; MacNee W
Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers.
American journal of respiratory and critical care medicine 1999;159(2):473-9.
1999: Lapperre T S; Jimenez L A; Antonicelli F; Drost E M; Hiemstra P S; Stolk J; MacNee W; Rahman I
Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells.
FEBS letters 1999;443(2):235-9.
1998: Skwarski K M; Morrison D; Barratt A; Lee M; MacNee W
Effects of hypoxia on renal hormonal balance in normal subjects and in patients with COPD.
Respiratory medicine 1998;92(12):1331-6.
1998: Morrison D; Strieter R M; Donnelly S C; Burdick M D; Kunkel S L; MacNee W
Neutrophil chemokines in bronchoalveolar lavage fluid and leukocyte-conditioned medium from nonsmokers and smokers.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;12(5):1067-72.
1998: Noguera A; Busquets X; Sauleda J; Villaverde J M; MacNee W; Agustí A G
Expression of adhesion molecules and G proteins in circulating neutrophils in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 1998;158(5 Pt 1):1664-8.
1998: Rahman I; MacNee W
Role of transcription factors in inflammatory lung diseases.
Thorax 1998;53(7):601-12.
1998: Rahman I; Bel A; Mulier B; Donaldson K; MacNee W
Differential regulation of glutathione by oxidants and dexamethasone in alveolar epithelial cells.
The American journal of physiology 1998;275(1 Pt 1):L80-6.
1998: Rahman I; Smith C A; Antonicelli F; MacNee W
Characterisation of gamma-glutamylcysteine synthetase-heavy subunit promoter: a critical role for AP-1.
FEBS letters 1998;427(1):129-33.
1998: Li X Y; Donaldson K; MacNee W
Lipopolysaccharide-induced alveolar epithelial permeability: the role of nitric oxide.
American journal of respiratory and critical care medicine 1998;157(4 Pt 1):1027-33.
1998: Mulier B; Rahman I; Watchorn T; Donaldson K; MacNee W; Jeffery P K
Hydrogen peroxide-induced epithelial injury: the protective role of intracellular nonprotein thiols (NPSH).
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;11(2):384-91.
1997: Biernacki W; Redpath A T; Best J J; MacNee W
Measurement of CT lung density in patients with chronic asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(11):2455-9.
1997: Gilmour P S; Brown D M; Beswick P H; MacNee W; Rahman I; Donaldson K
Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors.
Environmental health perspectives 1997;105 Suppl 5():1313-7.
1997: Donaldson K; Brown D M; Mitchell C; Dineva M; Beswick P H; Gilmour P; MacNee W
Free radical activity of PM10: iron-mediated generation of hydroxyl radicals.
Environmental health perspectives 1997;105 Suppl 5():1285-9.
1997: Li X Y; Gilmour P S; Donaldson K; MacNee W
In vivo and in vitro proinflammatory effects of particulate air pollution (PM10).
Environmental health perspectives 1997;105 Suppl 5():1279-83.
1997: Rahman I; Skwarska E; MacNee W
Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease.
Thorax 1997;52(6):565-8.
1997: Morrison D; Skwarski K M; MacNee W
The adequacy of oxygenation in patients with hypoxic chronic obstructive pulmonary disease treated with long-term domiciliary oxygen.
Respiratory medicine 1997;91(5):287-91.
1996: Li X Y; Gilmour P S; Donaldson K; MacNee W
Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro.
Thorax 1996;51(12):1216-22.
1996: Gilmour P S; Brown D M; Lindsay T G; Beswick P H; MacNee W; Donaldson K
Adverse health effects of PM10 particles: involvement of iron in generation of hydroxyl radical.
Occupational and environmental medicine 1996;53(12):817-22.
1996: Rahman I; Bel A; Mulier B; Lawson M F; Harrison D J; Macnee W; Smith C A
Transcriptional regulation of gamma-glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells.
Biochemical and biophysical research communications 1996;229(3):832-7.
1996: Rahman I; Smith C A; Lawson M F; Harrison D J; MacNee W
Induction of gamma-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells.
FEBS letters 1996;396(1):21-5.
1996: Rahman I; Morrison D; Donaldson K; MacNee W
Systemic oxidative stress in asthma, COPD, and smokers.
American journal of respiratory and critical care medicine 1996;154(4 Pt 1):1055-60.
1996: Li X Y; Rahman I; Donaldson K; MacNee W
Mechanisms of cigarette smoke induced increased airspace permeability.
Thorax 1996;51(5):465-71.
1996: MacNee W; Morrison D; Rahman I; Li X Y; Donaldson K
Cigarette smoke and ozone-induced epithelial perturbation in vivo and in vitro. The role of glutathione.
Chest 1996;109(3 Suppl):39S.
1996: Drost E M; Macnee W; Smith S F
The effect of lipocortin 1 on neutrophil deformability.
Mediators of inflammation 1996;5(3):188-90.
1996: Rahman I; MacNee W
Role of oxidants/antioxidants in smoking-induced lung diseases.
Free radical biology & medicine 1996;21(5):669-81.
1995: Brown D M; Drost E; Donaldson K; MacNee W
Deformability and CD11/CD18 expression of sequestered neutrophils in normal and inflamed lungs.
American journal of respiratory cell and molecular biology 1995;13(5):531-9.
1995: Morrison D; Skwarski K; MacNee W
Review of the prescription of domiciliary long term oxygen therapy in Scotland.
Thorax 1995;50(10):1103-5.
1995: Rahman I; Li X Y; Donaldson K; Harrison D J; MacNee W
Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress.
The American journal of physiology 1995;269(3 Pt 1):L285-92.
1995: MacNee W; Rahman I
Oxidants/antioxidants in idiopathic pulmonary fibrosis.
Thorax 1995;50 Suppl 1():S53-8.
1995: Li X Y; Donaldson K; Brown D; MacNee W
The role of tumor necrosis factor in increased airspace epithelial permeability in acute lung inflammation.
American journal of respiratory cell and molecular biology 1995;13(2):185-95.
1995: Rahman I; Li X Y; Donaldson K; Macnee W
Cigarette smoke, glutathione metabolism and epithelial permeability in rat lungs.
Biochemical Society transactions 1995;23(2):235S.
1995: Li X; Donaldson K; MacNee W
Nitric oxide production, alveolar macrophages and type II alveolar epithelial cells in response to LPS in vivo and in vitro.
Biochemical Society transactions 1995;23(2):233S.
1994: MacNee W
Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease. Part two.
American journal of respiratory and critical care medicine 1994;150(4):1158-68.
1994: MacNee W
Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease. Part One.
American journal of respiratory and critical care medicine 1994;150(3):833-52.
1994: Bridgeman M M; Marsden M; Selby C; Morrison D; MacNee W
Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue.
Thorax 1994;49(7):670-5.
1994: Selby C; Drost E; Gillooly M; Cameron E; Lamb D; MacNee W
Neutrophil sequestration in lungs removed at surgery. The effect of microscopic emphysema.
American journal of respiratory and critical care medicine 1994;149(6):1526-33.
1994: Li X Y; Donaldson K; Rahman I; MacNee W
An investigation of the role of glutathione in increased epithelial permeability induced by cigarette smoke in vivo and in vitro.
American journal of respiratory and critical care medicine 1994;149(6):1518-25.
1993: Drost E M; Selby C; Bridgeman M M; MacNee W
Decreased leukocyte deformability after acute cigarette smoking in humans.
The American review of respiratory disease 1993;148(5):1277-83.
1993: Lamb D; McLean A; Gillooly M; Warren P M; Gould G A; MacNee W
Relation between distal airspace size, bronchiolar attachments, and lung function.
Thorax 1993;48(10):1012-7.
1993: Selby C; MacNee W
Factors affecting neutrophil transit during acute pulmonary inflammation: minireview.
Experimental lung research 1993;19(4):407-28.
1993: Skwarski K; Lee M; Turnbull L; MacNee W
Atrial natriuretic peptide in stable and decompensated chronic obstructive pulmonary disease.
Thorax 1993;48(7):730-5.
1993: Gould G A; Redpath A T; Ryan M; Warren P M; Best J J; Cameron E J; MacNee W
Parenchymal emphysema measured by CT lung density correlates with lung function in patients with bullous disease.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(5):698-704.
1993: Skwarski K M; Gorecka D; Sliwinski P; Hogg J C; MacNee W
The effects of cigarette smoking on pulmonary hemodynamics.
Chest 1993;103(4):1166-72.
1993: MacNee W; Selby C
New perspectives on basic mechanisms in lung disease. 2. Neutrophil traffic in the lungs: role of haemodynamics, cell adhesion, and deformability.
Thorax 1993;48(1):79-88.
1992: Selby C; Drost E; Brown D; Howie S; MacNee W
Inhibition of neutrophil adherence and movement by acute cigarette smoke exposure.
Experimental lung research 1992;18(6):813-27.
1992: McLean A; Warren P M; Gillooly M; MacNee W; Lamb D
Microscopic and macroscopic measurements of emphysema: relation to carbon monoxide gas transfer.
Thorax 1992;47(3):144-9.
1992: Drost E M; Selby C; Lannan S; Lowe G D; MacNee W
Changes in neutrophil deformability following in vitro smoke exposure: mechanism and protection.
American journal of respiratory cell and molecular biology 1992;6(3):287-95.
1992: Skwarski K; Barratt A; MacNee W
Hemodynamic effects of ibopamine on the pulmonary circulation and right ventricular performance in patients with chronic obstructive pulmonary disease.
Cardiology 1992;80(5-6):349-55.
1991: Skwarski K; MacNee W; Wraith P K; Sliwinski P; Zielinski J
Predictors of survival in patients with chronic obstructive pulmonary disease treated with long-term oxygen therapy.
Chest 1991;100(6):1522-7.
1991: Selby C; Drost E; Wraith P K; MacNee W
In vivo neutrophil sequestration within lungs of humans is determined by in vitro "filterability".
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(5):1996-2003.
1991: Brown G M; Drost E; Donaldson K; MacGregor I; MacNee W
Reduction of the proteolytic activity of neutrophils by exposure to cigarette smoke in vitro.
Experimental lung research 1991;17(5):923-37.
1991: MacNee W; Bridgeman M M; Marsden M; Drost E; Lannan S; Selby C; Donaldson K
The effects of N-acetylcysteine and glutathione on smoke-induced changes in lung phagocytes and epithelial cells.
The American journal of medicine 1991;91(3C):60S-66S.
1991: Selby C; Drost E; Lannan S; Wraith P K; MacNee W
Neutrophil retention in the lungs of patients with chronic obstructive pulmonary disease.
The American review of respiratory disease 1991;143(6):1359-64.
1991: Drost E; Lannan S; Bridgeman M M; Brown D; Selby C; Donaldson K; MacNee W
Lack of effect of N-acetylcysteine on the release of oxygen radicals from neutrophils and alveolar macrophages.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1991;4(6):723-9.
1991: Gugger M; Gould G; Sudlow M F; Wraith P K; MacNee W
Extent of pulmonary emphysema in man and its relation to the loss of elastic recoil.
Clinical science (London, England : 1979) 1991;80(4):353-8.
1991: Gould G A; Redpath A T; Ryan M; Warren P M; Best J J; Flenley D C; MacNee W
Lung CT density correlates with measurements of airflow limitation and the diffusing capacity.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1991;4(2):141-6.
1991: Bridgeman M M; Marsden M; MacNee W; Flenley D C; Ryle A P
Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.
Thorax 1991;46(1):39-42.
1991: Selby C; Drost E; Wraith P K; MacNee W
Neutrophil traffic through the lungs in man.
Annals of the New York Academy of Sciences 1991;624():353-4.
1991: Donaldson K; Brown G M; Drost E; Selby C; MacNee W
Does cigarette smoke enhance the proteolytic activity of neutrophils?
Annals of the New York Academy of Sciences 1991;624():325-7.
1991: Brown G M; Drost E; Selby C; Donaldson K; MacNee W
Neutrophil sequestration in rat lungs.
Annals of the New York Academy of Sciences 1991;624():316-7.
1991: MacNee W; Gould G; Lamb D
Quantifying emphysema by CT scanning. Clinicopathologic correlates.
Annals of the New York Academy of Sciences 1991;624():179-94.
1990: Turnbull L W; Ridgway J P; Biernacki W; McRitchie H; Muir A L; Best J J; MacNee W
Assessment of the right ventricle by magnetic resonance imaging in chronic obstructive lung disease.
Thorax 1990;45(8):597-601.
1990: MacNee W
Should patients have cardiac catheterization prior to long-term oxygen treatment?
Lung 1990;168 Suppl():800-8.
1989: Biernacki W; Prince K; Whyte K; MacNee W; Flenley D C
The effect of six months of daily treatment with the beta-2 agonist oral pirbuterol on pulmonary hemodynamics in patients with chronic hypoxic cor pulmonale receiving long-term oxygen therapy.
The American review of respiratory disease 1989;139(2):492-7.
1988: Biernacki W; Flenley D C; Muir A L; MacNee W
Pulmonary hypertension and right ventricular function in patients with COPD.
Chest 1988;94(6):1169-75.
1988: France A J; Prescott R J; Biernacki W; Muir A L; MacNee W
Does right ventricular function predict survival in patients with chronic obstructive lung disease?
Thorax 1988;43(8):621-6.
1988: MacNee W; Wathen C G; Flenley D C; Muir A D
The effects of controlled oxygen therapy on ventricular function in patients with stable and decompensated cor pulmonale.
The American review of respiratory disease 1988;137(6):1289-95.
1988: Gould G A; MacNee W; McLean A; Warren P M; Redpath A; Best J J; Lamb D; Flenley D C
CT measurements of lung density in life can quantitate distal airspace enlargement--an essential defining feature of human emphysema.
The American review of respiratory disease 1988;137(2):380-92.
1988: MacNee W
Right ventricular function in cor pulmonale.
Cardiology 1988;75 Suppl 1():30-40.
1985: Catterall J R; Calverley P M; MacNee W; Warren P M; Shapiro C M; Douglas N J; Flenley D C
Mechanism of transient nocturnal hypoxemia in hypoxic chronic bronchitis and emphysema.
Journal of applied physiology (Bethesda, Md. : 1985) 1985;59(6):1698-703.

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