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Janet Macpherson

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Rhona E Aird; M Thomson; Janet S Macpherson; D E Thurston; D I Jodrell; S M Guichard
ABCB1 genetic polymorphism influences the pharmacology of the new pyrrolobenzodiazepine derivative SJG-136.
Sylvie M Guichard; Janet S Macpherson; Iain Mayer; Eilidh Reid; M Muir; Michael Dodds; Susan Alexander; Duncan I Jodrell
Gene expression predicts differential capecitabine metabolism, impacting on both pharmacokinetics and antitumour activity.
Sylvie M Guichard; M L Hua; P Kang; Janet S Macpherson; Duncan I Jodrell
Short hairpin RNAs targeting Bcl-xL modulate senescence and apoptosis following SN-38 and irinotecan exposure in a colon cancer model.

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2008: Rhona E Aird; M Thomson; Janet S Macpherson; D E Thurston; D I Jodrell; S M Guichard
ABCB1 genetic polymorphism influences the pharmacology of the new pyrrolobenzodiazepine derivative SJG-136.
The pharmacogenomics journal 2008;8(4):289-96.
2008: Sylvie M Guichard; Janet S Macpherson; Iain Mayer; Eilidh Reid; M Muir; Michael Dodds; Susan Alexander; Duncan I Jodrell
Gene expression predicts differential capecitabine metabolism, impacting on both pharmacokinetics and antitumour activity.
European journal of cancer (Oxford, England : 1990) 2008;44(2):310-7.
2007: Sylvie M Guichard; M L Hua; P Kang; Janet S Macpherson; Duncan I Jodrell
Short hairpin RNAs targeting Bcl-xL modulate senescence and apoptosis following SN-38 and irinotecan exposure in a colon cancer model.
Cancer chemotherapy and pharmacology 2007;60(5):651-60.
2006: Stéphanie Arnould; Victoria J Spanswick; Janet S Macpherson; John A Hartley; David E Thurston; Duncan I Jodrell; Sylvie M Guichard
Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling.
Molecular cancer therapeutics 2006;5(6):1602-9.
2006: Janet S Macpherson; Duncan I Jodrell; Sylvie M Guichard
Validation of real-time reverse-transcription-polymerase chain reaction for quantification of capecitabine-metabolizing enzymes.
Analytical biochemistry 2006;350(1):71-80.
2005: Sylvie M Guichard; Janet S Macpherson; David E Thurston; Duncan I Jodrell
Influence of P-glycoprotein expression on in vitro cytotoxicity and in vivo antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136.
European journal of cancer (Oxford, England : 1990) 2005;41(12):1811-8.
2005: Richard L Hayward; Q C Schornagel; R Tente; Janet S Macpherson; Rhona E Aird; Sylvie M Guichard; Abraha Habtemariam; Peter J Sadler; Duncan I Jodrell
Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175.
Cancer chemotherapy and pharmacology 2005;55(6):577-83.
2004: Richard L Hayward; Janet S Macpherson; Jeff Cummings; Brett P Monia; John F Smyth; Duncan I Jodrell
Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect.
Molecular cancer therapeutics 2004;3(2):169-78.
2003: Jeff Cummings; Brian T Ethell; Lesley Jardine; Gary Boyd; Janet S Macpherson; Brian Burchell; John F Smyth; Duncan I Jodrell
Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives.
Cancer research 2003;63(23):8443-50.
2003: Richard L Hayward; Janet S Macpherson; Jeff Cummings; Brett P Monia; John F Smyth; Duncan I Jodrell
Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2856-65.
2002: Jeff Cummings; Gary Boyd; Janet S Macpherson; Helga Wolf; Gillian Smith; John F Smyth; Duncan I Jodrell
Factors influencing the cellular accumulation of SN-38 and camptothecin.
Cancer chemotherapy and pharmacology 2002;49(3):194-200.
2002: Jeff Cummings; Gary Boyd; Brian T Ethell; Janet S Macpherson; Brian Burchell; John F Smyth; Duncan I Jodrell
Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation.
Biochemical pharmacology 2002;63(4):607-13.
1997: Janet S Macpherson; Jeff Cummings; I Meikle; Eric P Miller; John F Smyth
Cell cycle effects of the novel topoisomerase I inhibitor NU/ICRF 505 in a panel of Chinese hamster ovary cell lines.
European journal of cancer (Oxford, England : 1990) 1997;33(2):280-3.