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Dean Madden

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Jeanine F Amacher; Christopher D Bahl; Tobias Beck; Patrick R Cushing; Dean R Madden
Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop.
Alicia E Ballok; Emily L Dolben; Deborah A Hogan; Allia K Lindsay; Dean R Madden; Christopher D Bahl; Jessica D St Laurent; George A O'Toole
Epoxide-mediated CifR repression of cif gene expression utilizes two binding sites in Pseudomonas aeruginosa.
Christopher D Bahl; Dean R Madden
Pseudomonas aeruginosa Cif defines a distinct class of α/β epoxide hydrolases utilizing a His/Tyr ring-opening pair.

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All Publications

2013: Jeanine F Amacher; Christopher D Bahl; Tobias Beck; Patrick R Cushing; Dean R Madden
Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop.
The Journal of biological chemistry 2013;288(7):5114-26.
2012: Alicia E Ballok; Emily L Dolben; Deborah A Hogan; Allia K Lindsay; Dean R Madden; Christopher D Bahl; Jessica D St Laurent; George A O'Toole
Epoxide-mediated CifR repression of cif gene expression utilizes two binding sites in Pseudomonas aeruginosa.
Journal of bacteriology 2012;194(19):5315-24.
2012: Christopher D Bahl; Dean R Madden
Pseudomonas aeruginosa Cif defines a distinct class of α/β epoxide hydrolases utilizing a His/Tyr ring-opening pair.
Protein and peptide letters 2012;19(2):186-93.
2011: Jeanine F Amacher; Patrick R Cushing; Joshua A Weiner; Dean R Madden
Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 5):600-3.
2010: Patrick R Cushing; Lars Vouilleme; Maria Pellegrini; Prisca Boisguerin; Dean R Madden
A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR.
Angewandte Chemie (International ed. in English) 2010;49(51):9907-11.
2010: Christopher D Bahl; Christophe Morisseau; Jennifer M Bomberger; Bruce A Stanton; Bruce D Hammock; George A O'Toole; Dean R Madden
Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor.
Journal of bacteriology 2010;192(7):1785-95.
2010: Amanda Birdsey-Benson; Avinash Gill; Leslie P Henderson; Dean R Madden
Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(4):1463-70.
2010: Christopher D Bahl; Daniel P MacEachran; George A O'Toole; Dean R Madden
Purification, crystallization and preliminary X-ray diffraction analysis of Cif, a virulence factor secreted by Pseudomonas aeruginosa.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 1):26-8.
2008: Charles R Midgett; Dean R Madden
The quaternary structure of a calcium-permeable AMPA receptor: conservation of shape and symmetry across functionally distinct subunit assemblies.
Journal of molecular biology 2008;382(3):578-84.
2008: Patrick R Cushing; Abigail Fellows; Daniel Villone; Prisca Boisguérin; Dean R Madden
The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling.
Biochemistry 2008;47(38):10084-98.
2008: Avinash Gill; Dean R Madden
Purification and crystallization of a non-GluR2 AMPA-receptor ligand-binding domain: a case of cryo-incompatibility addressed by room-temperature data collection.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 9):831-5.
2007: Charles R Midgett; Dean R Madden
Breaking the bottleneck: eukaryotic membrane protein expression for high-resolution structural studies.
Journal of structural biology 2007;160(3):265-74.
2007: Michael Wolde; Abigail Fellows; Jie Cheng; Aleksandr Kivenson; Bonita Coutermarsh; Laleh Talebian; Katherine H Karlson; Andrea Piserchio; Dale F Mierke; Bruce A Stanton; William B Guggino; Dean R Madden
Targeting CAL as a negative regulator of DeltaF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach.
The Journal of biological chemistry 2007;282(11):8099-109.
2007: Dean R Madden; Markus Safferling
Baculoviral expression of an integral membrane protein for structural studies.
Methods in molecular biology (Clifton, N.J.) 2007;363():39-57.
2005: Andrea Piserchio; Abigail Fellows; Dean R Madden; Dale F Mierke
Association of the cystic fibrosis transmembrane regulator with CAL: structural features and molecular dynamics.
Biochemistry 2005;44(49):16158-66.
2005: James Féthière; David Venzke; Dean R Madden; Bettina Böttcher
Peripheral stator of the yeast V-ATPase: stoichiometry and specificity of interaction between the EG complex and subunits C and H.
Biochemistry 2005;44(48):15906-14.
2005: Dean R Madden; Neali Armstrong; Dmitri I Svergun; Javier Pérez; Patrice Vachette
Solution X-ray scattering evidence for agonist- and antagonist-induced modulation of cleft closure in a glutamate receptor ligand-binding domain.
The Journal of biological chemistry 2005;280(25):23637-42.
2004: Dean R Madden; Qing Cheng; Shalita Thiran; Shanti Rajan; Frank Rigo; Kari Keinänen; Stefan Reinelt; Herbert Zimmermann; Vasanthi Jayaraman
Stereochemistry of glutamate receptor agonist efficacy: engineering a dual-specificity AMPA/kainate receptor.
Biochemistry 2004;43(50):15838-44.
2004: Willem Tichelaar; Markus Safferling; Kari Keinänen; Holger Stark; Dean R Madden
The Three-dimensional Structure of an Ionotropic Glutamate Receptor Reveals a Dimer-of-dimers Assembly.
Journal of molecular biology 2004;344(2):435-42.
2003: Stefan Reinelt; Eckhard Hofmann; Tanja Gerharz; Michael Bott; Dean R Madden
The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain.
The Journal of biological chemistry 2003;278(40):39189-96.
2003: Arja Pasternack; Sarah K Coleman; James Féthière; Dean R Madden; Jean-Pierre LeCaer; Jean Rossier; Michael Pasternack; Kari Keinänen
Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain.
Journal of neurochemistry 2003;84(5):1184-92.
2002: Dean R Madden
The inner workings of the AMPA receptors.
Current opinion in drug discovery & development 2002;5(5):741-8.
2002: Dean R Madden
The structure and function of glutamate receptor ion channels.
Nature reviews. Neuroscience 2002;3(2):91-101.
2002: Boris Klockow; Willem Tichelaar; Dean R Madden; Hartmut H Niemann; Toshihiko Akiba; Keiko Hirose; Dietmar J Manstein
The dynamin A ring complex: molecular organization and nucleotide-dependent conformational changes.
The EMBO journal 2002;21(3):240-50.
2001: Markus Safferling; Willem Tichelaar; G Kümmerle; Annukka Jouppila; A Kuusinen; Kari Keinänen; Dean R Madden
First images of a glutamate receptor ion channel: oligomeric state and molecular dimensions of GluRB homomers.
Biochemistry 2001;40(46):13948-53.
2001: Dean R Madden; Shalita Thiran; H Zimmermann; J Romm; Vasanthi Jayaraman
Stereochemistry of quinoxaline antagonist binding to a glutamate receptor investigated by Fourier transform infrared spectroscopy.
The Journal of biological chemistry 2001;276(41):37821-6.
2000: James Féthière; A Andersson; Kari Keinänen; Dean R Madden
Crystallization of an AMPA receptor binding domain without agonist: importance of carbohydrate content and flash-cooling conditions.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 12):1625-9.
2000: Vasanthi Jayaraman; R Keesey; Dean R Madden
Ligand--protein interactions in the glutamate receptor.
Biochemistry 2000;39(30):8693-7.
2000: R Abele; K Keinanen; Dean R Madden
Agonist-induced isomerization in a glutamate receptor ligand-binding domain. A kinetic and mutagenetic analysis.
The Journal of biological chemistry 2000;275(28):21355-63.
2000: Dean R Madden; R Abele; A Andersson; Kari Keinänen
Large-scale expression and thermodynamic characterization of a glutamate receptor agonist-binding domain.
European journal of biochemistry / FEBS 2000;267(13):4281-9.
2000: Vasanthi Jayaraman; Shalita Thiran; Dean R Madden
Fourier transform infrared spectroscopic characterization of a photolabile precursor of glutamate.
FEBS letters 2000;475(3):278-82.
1999: A Kuusinen; R Abele; Dean R Madden; Kari Keinänen
Oligomerization and ligand-binding properties of the ectodomain of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit GluRD.
The Journal of biological chemistry 1999;274(41):28937-43.
1999: R Abele; D Svergun; Kari Keinänen; M H Koch; Dean R Madden
A molecular envelope of the ligand-binding domain of a glutamate receptor in the presence and absence of agonist.
Biochemistry 1999;38(34):10949-57.
1998: R Abele; Milla Lampinen; Kari Keinänen; Dean R Madden
Disulfide bonding and cysteine accessibility in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluRD. Implications for redox modulation of glutamate receptors.
The Journal of biological chemistry 1998;273(39):25132-8.
1995: Dean R Madden
The three-dimensional structure of peptide-MHC complexes.
Annual review of immunology 1995;13():587-622.