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Betty Maddux

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Umesh Masharani; Shelley McCoy; Christine Gjerde; Ira D Goldfine; Danielle Hessler; Betty A Maddux; Jack F Youngren
Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity.
Umesh B Masharani; Betty A Maddux; Xiaojuan Li; Giorgos K Sakkas; Kathleen Mulligan; Morris Schambelan; Ira D Goldfine; Jack F Youngren
Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.
Charles J Ryan; Marianna Zavodovskaya; Jack F Youngren; Michael Campbell; Marc Diamond; Jeremy Jones; Laura Shiry; Geoffrey Allan; Betty A Maddux; Ira D Goldfine
Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells.

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All Publications

2012: Umesh Masharani; Shelley McCoy; Christine Gjerde; Ira D Goldfine; Danielle Hessler; Betty A Maddux; Jack F Youngren
Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity.
BMC endocrine disorders 2012;12():31.
2011: Umesh B Masharani; Betty A Maddux; Xiaojuan Li; Giorgos K Sakkas; Kathleen Mulligan; Morris Schambelan; Ira D Goldfine; Jack F Youngren
Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.
PloS one 2011;6(5):e19878.
2008: Charles J Ryan; Marianna Zavodovskaya; Jack F Youngren; Michael Campbell; Marc Diamond; Jeremy Jones; Laura Shiry; Geoffrey Allan; Betty A Maddux; Ira D Goldfine
Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells.
The Prostate 2008;68(11):1232-40.
2008: Ira D Goldfine; Betty A Maddux; Jack F Youngren; Gerald Reaven; Domenico Accili; Vincenzo Trischitta; Riccardo Vigneri; Lucia Frittitta
The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.
Endocrine reviews 2008;29(1):62-75.
2008: Marianna Zavodovskaya; Michael J Campbell; Betty A Maddux; Laura Shiry; Geoffrey Allan; Leslie Hodges; Peter Kushner; John A Kerner; Jack F Youngren; Ira D Goldfine
Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells.
Journal of cellular biochemistry 2008;103(2):624-35.
2007: Gary E Meyer; Louis Chesler; Dandan Liu; Karissa L Gable; Betty A Maddux; David D Goldenberg; Jack F Youngren; Ira D Goldfine; William A Weiss; Katherine K Matthay; Stephen M Rosenthal
Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
Journal of cellular biochemistry 2007;102(6):1529-41.
2006: Marc O Anderson; Hong Yu; Cristina Penaranda; Betty A Maddux; Ira D Goldfine; Jack F Youngren; R Kiplin Guy
Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor.
Journal of combinatorial chemistry 2006;8(5):784-90.
2006: Betty A Maddux; Adelene Chan; Elena A De Filippis; Lawrence J. Manderino; Ira D Goldfine
IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance.
Diabetes care 2006;29(7):1535-7.
2006: Karissa L Gable; Betty A Maddux; Cristina Penaranda; Marianna Zavodovskaya; Michael J Campbell; Margaret Lobo; Louise Robinson; Steven Schow; John A Kerner; Ira D Goldfine; Jack F Youngren
Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.
Molecular cancer therapeutics 2006;5(4):1079-86.
2006: Betty A Maddux; Yow-Ning Chang; Domenico Accili; Owen P McGuinness; Jack F Youngren; Ira D Goldfine
Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.
American journal of physiology. Endocrinology and metabolism 2006;290(4):E746-9.
2005: Jack F Youngren; Karissa L Gable; Cristina Penaranda; Betty A Maddux; Marianna Zavodovskaya; Margaret Lobo; Michael Campbell; John Kerner; Ira D Goldfine
Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.
Breast cancer research and treatment 2005;94(1):37-46.
2005: David Meyre; Nabila Bouatia-Naji; Agnès Tounian; Chantal Samson; Cécile Lecoeur; Vincent Vatin; Maya Ghoussaini; Christophe Wachter; Serge Hercberg; Guillaume Charpentier; Wolfgang Patsch; François Pattou; Marie-Aline Charles; Patrick Tounian; Karine Clément; Béatrice Jouret; Jacques Weill; Betty A Maddux; Ira D Goldfine; Andrew J Walley; Philippe Boutin; Christian Dina; philippe froguel
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.
Nature genetics 2005;37(8):863-7.
2005: Joseph L Evans; Betty A Maddux; Ira D Goldfine
The molecular basis for oxidative stress-induced insulin resistance.
Antioxidants & redox signaling 2005;7(7-8):1040-52.
2005: Celia Pender; Ira D Goldfine; Jennifer L Kulp; Charles J Tanner; Betty A Maddux; Kenneth G MacDonald; Joseph A Houmard; Jack F Youngren
Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects.
Metabolism: clinical and experimental 2005;54(5):598-603.
2005: Hengjiang Dong; Betty A Maddux; Jennifer Altomonte; Marcia Meseck; Domenico Accili; Robert Terkeltaub; Kristen Johnson; Jack F Youngren; Ira D Goldfine
Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.
Diabetes 2005;54(2):367-72.
2004: Christopher Tan; Lianhu Wei; F Peter Ottensmeyer; Ira D Goldfine; Betty A Maddux; Cecil C Yip; Robert A Batey; Lakshmi P Kotra
Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor.
Bioorganic & medicinal chemistry letters 2004;14(6):1407-10.
2003: Joseph L Evans; Ira D Goldfine; Betty A Maddux; Gerold M Grodsky
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
Diabetes 2003;52(1):1-8.
2002: Celia Pender; Ira D Goldfine; Vara Prasad Manchem; Joseph L Evans; Wayne R Spevak; Songyuan Shi; Sandhya Rao; Sonia Bajjalieh; Betty A Maddux; Jack F Youngren
Regulation of insulin receptor function by a small molecule insulin receptor activator.
The Journal of biological chemistry 2002;277(46):43565-71.
2002: Joseph L Evans; Ira D Goldfine; Betty A Maddux; Gerold M Grodsky
Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes.
Endocrine reviews 2002;23(5):599-622.
2002: Ming Li; Jack F Youngren; Andrea Dunaif; Ira D Goldfine; Betty A Maddux; Bei B Zhang; Joseph L Evans
Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.
The Journal of clinical endocrinology and metabolism 2002;87(9):4088-93.
2001: M Li; Jack F Youngren; Vara Prasad Manchem; M Kozlowski; Bei B Zhang; Betty A Maddux; Ira D Goldfine
Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells.
Diabetes 2001;50(10):2323-8.
2001: Betty A Maddux; W See; J C Lawrence; A L Goldfine; Ira D Goldfine; Joseph L Evans
Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid.
Diabetes 2001;50(2):404-10.
2001: Frank Rutsch; Sucheta M Vaingankar; Kristen Johnson; Ira D Goldfine; Betty A Maddux; P Schauerte; Hermann Kalhoff; K Sano; William A Boisvert; andrea superti-furga; Robert Terkeltaub
PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification.
The American journal of pathology 2001;158(2):543-54.
2000: Betty A Maddux; Ira D Goldfine
Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.
Diabetes 2000;49(1):13-9.
1999: Ira D Goldfine; Betty A Maddux; Jack F Youngren; Vincenzo Trischitta; Lucia Frittitta
Role of PC-1 in the etiology of insulin resistance.
Annals of the New York Academy of Sciences 1999;892():204-22.
1999: Lucia Frittitta; S Camastra; Roberto Baratta; BV Costanzo; Monica D'Adamo; S Graci; Daniela Spampinato; Betty A Maddux; Riccardo Vigneri; E Ferrannini; Vincenzo Trischitta
A soluble PC-1 circulates in human plasma: relationship with insulin resistance and associated abnormalities.
The Journal of clinical endocrinology and metabolism 1999;84(10):3620-5.
1998: Ira D Goldfine; Betty A Maddux; Jack F Youngren; Lucia Frittitta; Vincenzo Trischitta; G Lynis Dohm
Membrane glycoprotein PC-1 and insulin resistance.
Molecular and cellular biochemistry 1998;182(1-2):177-84.
1998: S Kumakura; Betty A Maddux; C K Sung
Overexpression of membrane glycoprotein PC-1 can influence insulin action at a post-receptor site.
Journal of cellular biochemistry 1998;68(3):366-77.
1996: Antonino Belfiore; Angela Costantino; Francesco Frasca; Giuseppe Pandini; Rossana Mineo; P Vigneri; Betty A Maddux; Ira D Goldfine; Riccardo Vigneri
Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity.
Molecular endocrinology (Baltimore, Md.) 1996;10(11):1318-26.
1996: Lucia Frittitta; Jack F Youngren; Riccardo Vigneri; Betty A Maddux; Vincenzo Trischitta; Ira D Goldfine
PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity.
Diabetologia 1996;39(10):1190-5.
1996: Jack F Youngren; Betty A Maddux; S Sasson; Paolo Sbraccia; E B Tapscott; M S Swanson; G L Dohm; Ira D Goldfine
Skeletal muscle content of membrane glycoprotein PC-1 in obesity. Relationship to muscle glucose transport.
Diabetes 1996;45(10):1324-8.
1995: Betty A Maddux; Paolo Sbraccia; S Kumakura; S Sasson; Jack F Youngren; A Fisher; S Spencer; A Grupe; W Henzel; Timothy A Stewart
Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus.
Nature 1995;373(6513):448-51.
1993: Betty A Maddux; Paolo Sbraccia; G M Reaven; D E Moller; Ira D Goldfine
Inhibitors of insulin receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action: evidence for a novel mechanism of postreceptor insulin resistance.
The Journal of clinical endocrinology and metabolism 1993;77(1):73-9.
1992: Giovanni Milazzo; Cecil C Yip; Betty A Maddux; Riccardo Vigneri; Ira D Goldfine
High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells.
The Journal of clinical investigation 1992;89(3):899-908.
1992: C K Sung; X L Han; Antonio Brunetti; Betty A Maddux; R Yamamoto-Honda; Ira D Goldfine
Regulation of biological functions by an insulin receptor monoclonal antibody in insulin receptor beta-subunit mutants.
Biochemistry 1992;31(1):168-74.
1991: R Rafaeloff; Betty A Maddux; Antonio Brunetti; Paolo Sbraccia; C K Sung; R Patel; D M Hawley; Ira D Goldfine
Transmembrane signalling by insulin via an insulin receptor mutated at tyrosines 1158, 1162, and 1163.
Biochemical and biophysical research communications 1991;179(2):912-8.
1991: Vincenzo Papa; K K Hartmann; S M Rosenthal; Betty A Maddux; Pentti Siiteri; Ira D Goldfine
Progestins induce down-regulation of insulin-like growth factor-I (IGF-I) receptors in human breast cancer cells: potential autocrine role of IGF-II.
Molecular endocrinology (Baltimore, Md.) 1991;5(5):709-17.
1991: Betty A Maddux; Ira D Goldfine
Evidence that insulin plus ATP may induce a conformational change in the beta subunit of the insulin receptor without inducing receptor autophosphorylation.
The Journal of biological chemistry 1991;266(11):6731-6.
1991: F Giorgino; Antonino Belfiore; Giovanni Milazzo; Angela Costantino; Betty A Maddux; J Whittaker; Ira D Goldfine; Riccardo Vigneri
Overexpression of insulin receptors in fibroblast and ovary cells induces a ligand-mediated transformed phenotype.
Molecular endocrinology (Baltimore, Md.) 1991;5(3):452-9.
1991: Paolo Sbraccia; P A Goodman; Betty A Maddux; K Y Wong; Y D Chen; G M Reaven; Ira D Goldfine
Production of inhibitor of insulin-receptor tyrosine kinase in fibroblasts from patient with insulin resistance and NIDDM.
Diabetes 1991;40(2):295-9.
1990: P W Mamula; A R McDonald; Antonio Brunetti; Y Okabayashi; K Y Wong; Betty A Maddux; Craig D Logsdon; Ira D Goldfine
Regulating insulin-receptor-gene expression by differentiation and hormones.
Diabetes care 1990;13(3):288-301.
1989: C K Sung; Betty A Maddux; D M Hawley; Ira D Goldfine
Monoclonal antibodies mimic insulin activation of ribosomal protein S6 kinase without activation of insulin receptor tyrosine kinase. Studies in cells transfected with normal and mutant human insulin receptors.
The Journal of biological chemistry 1989;264(32):18951-9.
1989: Vincenzo Pezzino; Vincenzo Papa; Vincenzo Trischitta; Antonio Brunetti; P A Goodman; M K Treutelaar; John Williams; Betty A Maddux; Riccardo Vigneri; Ira D Goldfine
Human insulin receptor radioimmunoassay: applicability to insulin-resistant states.
The American journal of physiology 1989;257(3 Pt 1):E451-7.
1989: D M Hawley; Betty A Maddux; R G Patel; K Y Wong; P W Mamula; Gary L Firestone; Antonio Brunetti; E Verspohl; Ira D Goldfine
Insulin receptor monoclonal antibodies that mimic insulin action without activating tyrosine kinase.
The Journal of biological chemistry 1989;264(5):2438-44.
1989: Y Okabayashi; Betty A Maddux; A R McDonald; Craig D Logsdon; John Williams; Ira D Goldfine
Mechanisms of insulin-induced insulin-receptor downregulation. Decrease of receptor biosynthesis and mRNA levels.
Diabetes 1989;38(2):182-7.
1989: Antonio Brunetti; Betty A Maddux; K Y Wong; Ira D Goldfine
Muscle cell differentiation is associated with increased insulin receptor biosynthesis and messenger RNA levels.
The Journal of clinical investigation 1989;83(1):192-8.
1988: Cecil C Yip; H Hsu; R G Patel; D M Hawley; Betty A Maddux; Ira D Goldfine
Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor alpha-subunit.
Biochemical and biophysical research communications 1988;157(1):321-9.
1988: P W Mamula; K Y Wong; Betty A Maddux; A R McDonald; Ira D Goldfine
Sequence and analysis of promoter region of human insulin-receptor gene.
Diabetes 1988;37(9):1241-6.
1988: E J Verspohl; Betty A Maddux; Ira D Goldfine
Insulin and insulin-like growth factor I regulate the same biological functions in HEP-G2 cells via their own specific receptors.
The Journal of clinical endocrinology and metabolism 1988;67(1):169-74.
1988: Stefan Rosewicz; A R McDonald; Betty A Maddux; Ira D Goldfine; R L Miesfeld; Craig D Logsdon
Mechanism of glucocorticoid receptor down-regulation by glucocorticoids.
The Journal of biological chemistry 1988;263(6):2581-4.
1987: A R McDonald; Betty A Maddux; Y Okabayashi; K Y Wong; D M Hawley; Craig D Logsdon; Ira D Goldfine
Regulation of insulin-receptor mRNA levels by glucocorticoids.
Diabetes 1987;36(6):779-81.