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Manuela Bartolini
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Research Profile (preview)
Chemicals & Drugs
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Procedures
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Occupations
Phenomena
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Network (preview)
35
Andrisano, Vincenza
17
Cavalli, Andrea
17
Melchiorre, Carlo
16
Recanatini, Maurizio
14
Rosini, Michela
12
Bolognesi, Maria Laura
10
Minarini, Anna
9
Belluti, Federica
9
Cavrini, Vanni
9
Tumiatti, Vincenzo
9
Rampa, Angela
8
Piazzi, Lorna
8
Bisi, Alessandra
7
Gobbi, Silvia
5
Bertucci, Carlo
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All Publications
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2009: Bolognesi Maria Laura; Bartolini Manuela; Rosini Michela; Andrisano Vincenza; Melchiorre Carlo
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.
Bioorganic & medicinal chemistry letters 2009;19(15):4312-5.
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2009: Rizzo Stefano; Cavalli Andrea; Ceccarini Luisa; Bartolini Manuela; Belluti Federica; Bisi Alessandra; Andrisano Vincenza; Recanatini Maurizio; Rampa Angela
Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine.
ChemMedChem 2009;4(4):670-9.
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2009: Bartolini Manuela; Greig Nigel H; Yu Qian-Sheng; Andrisano Vincenza
Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease.
Journal of chromatography. A 2009;1216(13):2730-8.
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2009: Belluti Federica; Piazzi Lorna; Bisi Alessandra; Gobbi Silvia; Bartolini Manuela; Cavalli Andrea; Valenti Piero; Rampa Angela
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.
European journal of medicinal chemistry 2009;44(3):1341-8.
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2009: Bolognesi M L; Rosini M; Andrisano V; Bartolini M; Minarini A; Tumiatti V; Melchiorre C
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.
Current pharmaceutical design 2009;15(6):601-13.
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2008: Tumiatti Vincenzo; Milelli Andrea; Minarini Anna; Rosini Michela; Bolognesi Maria Laura; Micco Marialuisa; Andrisano Vincenza; Bartolini Manuela; Mancini Francesca; Recanatini Maurizio; Cavalli Andrea; Melchiorre Carlo
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.
Journal of medicinal chemistry 2008;51(22):7308-12.
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2008: Rosini Michela; Simoni Elena; Bartolini Manuela; Cavalli Andrea; Ceccarini Luisa; Pascu Nicoleta; McClymont David W; Tarozzi Andrea; Bolognesi Maria L; Minarini Anna; Tumiatti Vincenzo; Andrisano Vincenza; Mellor Ian R; Melchiorre Carlo
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.
Journal of medicinal chemistry 2008;51(15):4381-4.
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2008: Petraglio Gabriele; Bartolini Manuela; Branduardi Davide; Andrisano Vincenza; Recanatini Maurizio; Gervasio Francesco Luigi; Cavalli Andrea; Parrinello Michele
The role of Li+, Na+, and K+ in the ligand binding inside the human acetylcholinesterase gorge.
Proteins 2008;70(3):779-85.
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2008: Piazzi Lorna; Cavalli Andrea; Colizzi Francesco; Belluti Federica; Bartolini Manuela; Mancini Francesca; Recanatini Maurizio; Andrisano Vincenza; Rampa Angela
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.
Bioorganic & medicinal chemistry letters 2008;18(1):423-6.
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2007: Bolognesi Maria Laura; Cavalli Andrea; Valgimigli Luca; Bartolini Manuela; Rosini Michela; Andrisano Vincenza; Recanatini Maurizio; Melchiorre Carlo
Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.
Journal of medicinal chemistry 2007;50(26):6446-9.
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2007: Bartolini Manuela; Bertucci Carlo; Bolognesi Maria Laura; Cavalli Andrea; Melchiorre Carlo; Andrisano Vincenza
Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of action.
Chembiochem : a European journal of chemical biology 2007;8(17):2152-61.
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2007: Bolognesi Maria Laura; Banzi Rita; Bartolini Manuela; Cavalli Andrea; Tarozzi Andrea; Andrisano Vincenza; Minarini Anna; Rosini Michela; Tumiatti Vincenzo; Bergamini Christian; Fato Romana; Lenaz Giorgio; Hrelia Patrizia; Cattaneo Antonino; Recanatini Maurizio; Melchiorre Carlo
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.
Journal of medicinal chemistry 2007;50(20):4882-97.
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2007: Piazzi Lorna; Cavalli Andrea; Belluti Federica; Bisi Alessandra; Gobbi Silvia; Rizzo Stefano; Bartolini Manuela; Andrisano Vincenza; Recanatini Maurizio; Rampa Angela
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.
Journal of medicinal chemistry 2007;50(17):4250-4.
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2007: Bartolini Manuela; Cavrini Vanni; Andrisano Vincenza
Characterization of reversible and pseudo-irreversible acetylcholinesterase inhibitors by means of an immobilized enzyme reactor.
Journal of chromatography. A 2007;1144(1):102-10.
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2007: Piazzi Lorna; Belluti Federica; Bisi Alessandra; Gobbi Silvia; Rizzo Stefano; Bartolini Manuela; Andrisano Vincenza; Recanatini Maurizio; Rampa Angela
Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.
Bioorganic & medicinal chemistry 2007;15(1):575-85.
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2007: Cavalli Andrea; Bolognesi Maria Laura; Capsoni Simona; Andrisano Vincenza; Bartolini Manuela; Margotti Elisa; Cattaneo Antonino; Recanatini Maurizio; Melchiorre Carlo
A small molecule targeting the multifactorial nature of Alzheimer's disease.
Angewandte Chemie (International ed. in English) 2007;46(20):3689-92.
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2006: Gotti R; Fiori J; Bartolini M; Cavrini V
Analysis of Amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis.
Journal of pharmaceutical and biomedical analysis 2006;42(1):17-24.
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2006: Temporini C; Perani E; Mancini F; Bartolini M; Calleri E; Lubda D; Felix G; Andrisano V; Massolini G
Optimization of a trypsin-bioreactor coupled with high-performance liquid chromatography-electrospray ionization tandem mass spectrometry for quality control of biotechnological drugs.
Journal of chromatography. A 2006;1120(1-2):121-31.
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2005: Bartolini M; Cavrini V; Andrisano V
Batchwise covalent immobilization of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies.
Analytical biochemistry 2005;342(1):163-6.
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2005: Belluti Federica; Rampa Angela; Piazzi Lorna; Bisi Alessandra; Gobbi Silvia; Bartolini Manuela; Andrisano Vincenza; Cavalli Andrea; Recanatini Maurizio; Valenti Piero
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation.
Journal of medicinal chemistry 2005;48(13):4444-56.
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2005: Bolognesi Maria Laura; Andrisano Vincenza; Bartolini Manuela; Cavalli Andrea; Minarini Anna; Recanatini Maurizio; Rosini Michela; Tumiatti Vincenzo; Melchiorre Carlo
Heterocyclic inhibitors of AChE acylation and peripheral sites.
Farmaco (Società chimica italiana : 1989) 2005;60(6-7):465-73.
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2005: Rosini Michela; Andrisano Vincenza; Bartolini Manuela; Bolognesi Maria L; Hrelia Patrizia; Minarini Anna; Tarozzi Andrea; Melchiorre Carlo
Rational approach to discover multipotent anti-Alzheimer drugs.
Journal of medicinal chemistry 2005;48(2):360-3.
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2005: Bolognesi Maria Laura; Andrisano Vincenza; Bartolini Manuela; Banzi Rita; Melchiorre Carlo
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.
Journal of medicinal chemistry 2005;48(1):24-7.
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2004: Tumiatti Vincenzo; Andrisano Vincenza; Banzi Rita; Bartolini Manuela; Minarini Anna; Rosini Michela; Melchiorre Carlo
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.
Journal of medicinal chemistry 2004;47(26):6490-8.
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2004: Bolognesi Maria Laura; Bartolini Manuela; Cavalli Andrea; Andrisano Vincenza; Rosini Michela; Minarini Anna; Melchiorre Carlo
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues.
Journal of medicinal chemistry 2004;47(24):5945-52.
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2004: Bartolini M; Cavrini V; Andrisano V
Monolithic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies.
Journal of chromatography. A 2004;1031(1-2):27-34.
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2003: Bertucci C; Bartolini M; Gotti R; Andrisano V
Drug affinity to immobilized target bio-polymers by high-performance liquid chromatography and capillary electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;797(1-2):111-29.
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2003: Bolognesi Maria Laura; Cavalli Andrea; Andrisano Vincenza; Bartolini Manuela; Banzi Rita; Antonello Alessandra; Rosini Michela; Melchiorre Carlo
Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors.
Farmaco (Società chimica italiana : 1989) 2003;58(9):917-28.
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2003: Andrisano V; Bartolini M; Bertucci C; Cavrini V; Luppi B; Cerchiara T
Analytical methods for the determination of folic acid in a polymeric micellar carrier.
Journal of pharmaceutical and biomedical analysis 2003;32(4-5):983-9.
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2003: Piazzi Lorna; Rampa Angela; Bisi Alessandra; Gobbi Silvia; Belluti Federica; Cavalli Andrea; Bartolini Manuela; Andrisano Vincenza; Valenti Piero; Recanatini Maurizio
3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.
Journal of medicinal chemistry 2003;46(12):2279-82.
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2003: Tumiatti Vincenzo; Rosini Michela; Bartolini Manuela; Cavalli Andrea; Marucci Gabriella; Andrisano Vincenza; Angeli Piero; Banzi Rita; Minarini Anna; Recanatini Maurizio; Melchiorre Carlo
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Journal of medicinal chemistry 2003;46(6):954-66.
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2003: Bartolini Manuela; Bertucci Carlo; Cavrini Vanni; Andrisano Vincenza
beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies.
Biochemical pharmacology 2003;65(3):407-16.
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2002: Bolognesi Maria L; Bixel M Gabriele; Marucci Gabriella; Bartolini Manuela; Krauss Michael; Angeli Piero; Antonello Alessandra; Rosini Michela; Tumiatti Vincenzo; Hucho Ferdinand; Melchiorre Carlo
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure.
Journal of medicinal chemistry 2002;45(15):3286-95.
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2002: Bartolini M; Bertucci C; Gotti R; Tumiatti V; Cavalli A; Recanatini M; Andrisano V
Determination of the dissociation constants (pKa) of basic acetylcholinesterase inhibitors by reversed-phase liquid chromatography.
Journal of chromatography. A 2002;958(1-2):59-67.
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2001: Rampa A; Piazzi L; Belluti F; Gobbi S; Bisi A; Bartolini M; Andrisano V; Cavrini V; Cavalli A; Recanatini M; Valenti P
Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.
Journal of medicinal chemistry 2001;44(23):3810-20.
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2001: Andrisano V; Bartolini M; Gotti R; Cavrini V; Felix G
Determination of inhibitors' potency (IC50) by a direct high-performance liquid chromatographic method on an immobilised acetylcholinesterase column.
Journal of chromatography. B, Biomedical sciences and applications 2001;753(2):375-83.
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2001: Bolognesi M L; Andrisano V; Bartolini M; Minarini A; Rosini M; Tumiatti V; Melchiorre C
Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.
Journal of medicinal chemistry 2001;44(1):105-9.
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2000: Recanatini M; Cavalli A; Belluti F; Piazzi L; Rampa A; Bisi A; Gobbi S; Valenti P; Andrisano V; Bartolini M; Cavrini V
SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues.
Journal of medicinal chemistry 2000;43(10):2007-18.
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