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Inger Helene Madshus

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Tram Thu Vuong; Christian Berger; Vibeke Bertelsen; Marianne Skeie Rødland; espen stang; Inger Helene Madshus
Preubiquitinated chimeric ErbB2 is constitutively endocytosed and subsequently degraded in lysosomes.
Christian Berger; Inger Helene Madshus; espen stang
Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis.
Malgorzata Magdalena Sak; Espen Stang; Vibeke Bertelsen; Kamilla Breen; Nina Marie Pedersen; Sissel Beate Rønning; Inger Helene Madshus
The oncoprotein ErbB3 is endocytosed in the absence of added ligand in a clathrin-dependent manner.

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All Publications

2013: Tram Thu Vuong; Christian Berger; Vibeke Bertelsen; Marianne Skeie Rødland; espen stang; Inger Helene Madshus
Preubiquitinated chimeric ErbB2 is constitutively endocytosed and subsequently degraded in lysosomes.
Experimental cell research 2013;319(3):32-45.
2012: Christian Berger; Inger Helene Madshus; espen stang
Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis.
Experimental cell research 2012;318(20):2578-91.
2012: Malgorzata Magdalena Sak; Espen Stang; Vibeke Bertelsen; Kamilla Breen; Nina Marie Pedersen; Sissel Beate Rønning; Inger Helene Madshus
The oncoprotein ErbB3 is endocytosed in the absence of added ligand in a clathrin-dependent manner.
Carcinogenesis 2012;33(5):1031-9.
2012: Michael V Grandal; Lene M Grøvdal; Lasse Henriksen; Mikkel R Holst; Inger Helene Madshus; Mette H Andersen; Bo van Deurs
Differential roles of Grb2 and AP-2 in p38 MAPK- and EGF-induced EGFR internalization.
Traffic (Copenhagen, Denmark) 2012;13(4):576-85.
2011: Sissel Beate Rønning; Inger Helene Madshus; Nina Marie Pedersen; espen stang
CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor.
Experimental cell research 2011;317(13):1804-16.
2011: Vibeke Bertelsen; Malgorzata Magdalena Sak; Kamilla Breen; Marianne S Rødland; Lene E Johannessen; Linton Traub; espen stang; Inger Helene Madshus
A chimeric pre-ubiquitinated EGF receptor is constitutively endocytosed in a clathrin-dependent, but kinase-independent manner.
Traffic (Copenhagen, Denmark) 2011;12(4):507-20.
2009: Inger Helene Madshus; espen stang
Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking.
Journal of cell science 2009;122(Pt 19):3433-9.
2009: Juliana Bentes Hughes; Christian Berger; Marianne Skeie Rødland; Max Hasmann; Espen Stang; Inger Helene Madshus
Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization.
Molecular cancer therapeutics 2009;8(7):1885-92.
2009: Nina Marie Pedersen; Kamilla Breen; Marianne Skeie Rødland; Camilla Haslekås; espen stang; Inger Helene Madshus
Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2.
Molecular cancer research : MCR 2009;7(2):275-84.
2009: Maja Kazazic; Vibeke Bertelsen; Ketil Winther Pedersen; Tram Thu Vuong; Michael Vibo Grandal; Marianne Skeie Rødland; Linton M Traub; espen stang; Inger Helene Madshus
Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits.
Traffic (Copenhagen, Denmark) 2009;10(2):235-45.
2008: Michael Vibo Grandal; Inger Helene Madshus
Epidermal growth factor receptor and cancer: control of oncogenic signalling by endocytosis.
Journal of cellular and molecular medicine 2008;12(5A):1527-34.
2008: Lene Melsaether Grøvdal; Lene E Johannessen; Marianne Skeie Rødland; Inger Helene Madshus; espen stang
Dysregulation of Ack1 inhibits down-regulation of the EGF receptor.
Experimental cell research 2008;314(6):1292-300.
2008: Nina Marie Pedersen; Inger Helene Madshus; Camilla Haslekås; espen stang
Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent.
Molecular cancer research : MCR 2008;6(3):491-500.
2007: Vibeke Bertelsen; Kamilla Breen; Kirsten Sandvig; espen stang; Inger Helene Madshus
The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis.
Experimental cell research 2007;313(8):1696-709.
2006: Maja Kazazic; Kirstine Roepstorff; Lene E Johannessen; Nina Marie Pedersen; Bo van Deurs; espen stang; Inger Helene Madshus
EGF-induced activation of the EGF receptor does not trigger mobilization of caveolae.
Traffic (Copenhagen, Denmark) 2006;7(11):1518-27.
2006: Frøydis D Myromslien; Lene Melsaether Grøvdal; Camilla Raiborg; Harald Stenmark; Inger Helene Madshus; espen stang
Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor.
Experimental cell research 2006;312(16):3036-48.
2006: Inger Helene Madshus
Ubiquitin binding in endocytosis--how tight should it be and where does it happen?
Traffic (Copenhagen, Denmark) 2006;7(3):258-61.
2006: Lene E Johannessen; Nina Marie Pedersen; Ketil Winther Pedersen; Inger Helene Madshus; espen stang
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits.
Molecular and cellular biology 2006;26(2):389-401.
2005: Camilla Haslekås; Kamilla Breen; Ketil Winther Pedersen; Lene E Johannessen; espen stang; Inger Helene Madshus
The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane.
Molecular biology of the cell 2005;16(12):5832-42.
2005: Karianne E Longva; Nina Marie Pedersen; Camilla Haslekås; espen stang; Inger Helene Madshus
Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2.
International journal of cancer. Journal international du cancer 2005;116(3):359-67.
2004: Lene Melsaether Grøvdal; espen stang; Alexander Sorkin; Inger Helene Madshus
Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation.
Experimental cell research 2004;300(2):388-95.
2004: espen stang; Frøydis D Blystad; Maja Kazazic; Vibeke Bertelsen; Tonje Brodahl; Camilla Raiborg; Harald Stenmark; Inger Helene Madshus
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits.
Molecular biology of the cell 2004;15(8):3591-604.
2003: Are P Normann; Thore Egeland; Inger Helene Madshus; Sverre Heim; Geir Tjønnfjord
CD7 expression by CD34+ cells in CML patients, of prognostic significance?
European journal of haematology 2003;71(4):266-75.
2002: Kristi G Bache; Camilla Raiborg; Anja Mehlum; Inger Helene Madshus; Harald Stenmark
Phosphorylation of Hrs downstream of the epidermal growth factor receptor.
European journal of biochemistry / FEBS 2002;269(16):3881-7.
2002: Camilla Raiborg; Kristi G Bache; David J Gillooly; Inger Helene Madshus; espen stang; Harald Stenmark
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes.
Nature cell biology 2002;4(5):394-8.
2002: Tove Ringerike; Frøydis D Blystad; Finn Olav Levy; Inger Helene Madshus; espen stang
Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae.
Journal of cell science 2002;115(Pt 6):1331-40.
2002: Karianne E Longva; Frøydis D Blystad; espen stang; Astrid M Larsen; Lene E Johannessen; Inger Helene Madshus
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies.
The Journal of cell biology 2002;156(5):843-54.
2002: M Oksvold; Henrik S Huitfeldt; espen stang; Inger Helene Madshus
Localizing the EGF receptor.
Nature cell biology 2002;4(2):E22; author reply E22-3.
2001: Lene E Johannessen; K E Haugen; Anne Carine Østvold; espen stang; Inger Helene Madshus
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms.
The Biochemical journal 2001;356(Pt 1):87-96.
2000: Lene E Johannessen; Tove Ringerike; J Molnes; Inger Helene Madshus
Epidermal growth factor receptor efficiently activates mitogen-activated protein kinase in HeLa cells and Hep2 cells conditionally defective in clathrin-dependent endocytosis.
Experimental cell research 2000;260(1):136-45.
2000: espen stang; Lene E Johannessen; S L Knardal; Inger Helene Madshus
Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation.
The Journal of biological chemistry 2000;275(18):13940-7.
1999: Lene E Johannessen; S L Knardal; Inger Helene Madshus
Epidermal growth factor increases the level of the cyclin-dependent kinase (CDK) inhibitor p21/CIP1 (CDK-interacting protein 1) in A431 cells by increasing the half-lives of the p21/CIP1 transcript and the p21/CIP1 protein.
The Biochemical journal 1999;337 ( Pt 3)():599-606.
1999: B Lindeman; Ellen Skarpen; G Hege Thoresen; Thoralf Christoffersen; Lene Wierød; Inger Helene Madshus; Henrik S Huitfeldt
Alteration of G1 cell-cycle protein expression and induction of p53 but not p21/waf1 by the DNA-modifying carcinogen 2-acetylaminofluorene in growth-stimulated hepatocytes in vitro.
Molecular carcinogenesis 1999;24(1):36-46.
1998: Ellen Skarpen; Lene E Johannessen; K Bjerk; H Fasteng; Tormod K Guren; B Lindeman; G Hege Thoresen; Thoralf Christoffersen; espen stang; Henrik S Huitfeldt; Inger Helene Madshus
Endocytosed epidermal growth factor (EGF) receptors contribute to the EGF-mediated growth arrest in A431 cells by inducing a sustained increase in p21/CIP1.
Experimental cell research 1998;243(1):161-72.
1998: Tove Ringerike; espen stang; Lene E Johannessen; Dagny Sandnes; Finn Olav Levy; Inger Helene Madshus
High-affinity binding of epidermal growth factor (EGF) to EGF receptor is disrupted by overexpression of mutant dynamin (K44A).
The Journal of biological chemistry 1998;273(27):16639-42.