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Hiroshi Maegawa

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Shinji Kume; Hiroshi Maegawa; Keizo Kanasaki; Munehiro Kitada; Daisuke Koya
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Chisato Kusunoki; Atsushi Ishikado; Atsunori Kashiwagi; Motoyuki Kondo; Katsutaro Morino; Fumiyuki Nakagawa; Yoshihiko Nishio; Osamu Sekine; Satoshi Ugi; Liu Yang; Takeshi Yoshizaki; Hiroshi Maegawa
Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes.
Hiroshi Urabe; Hitoshi Yasuda; Hideto Kojima; Asako Kumagai; Hiroshi Maegawa; Nobuhiro Ogawa; Kazuhiro Oka; Tomoya Terashima; Akihiro Asakawa; Lawrence Chan; Yutaka Eguchi; Kazunori Fujino; Akio Inui; Atsunori Kashiwagi; Miwako Katagi; Hiromichi Kawai; Hiroshi Kimura
Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus.

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All Publications

2013: Shinji Kume; Hiroshi Maegawa; Keizo Kanasaki; Munehiro Kitada; Daisuke Koya
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Archives of pharmacal research 2013;36(2):230-6.
2013: Chisato Kusunoki; Atsushi Ishikado; Atsunori Kashiwagi; Motoyuki Kondo; Katsutaro Morino; Fumiyuki Nakagawa; Yoshihiko Nishio; Osamu Sekine; Satoshi Ugi; Liu Yang; Takeshi Yoshizaki; Hiroshi Maegawa
Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes.
Biochemical and biophysical research communications 2013;430(1):225-30.
2013: Hiroshi Urabe; Hitoshi Yasuda; Hideto Kojima; Asako Kumagai; Hiroshi Maegawa; Nobuhiro Ogawa; Kazuhiro Oka; Tomoya Terashima; Akihiro Asakawa; Lawrence Chan; Yutaka Eguchi; Kazunori Fujino; Akio Inui; Atsunori Kashiwagi; Miwako Katagi; Hiromichi Kawai; Hiroshi Kimura
Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus.
Nature communications 2013;4():1526.
2012: Hirotaka Yamamoto; Takeshi Yoshizaki; Atsunori Kashiwagi; Katsutaro Morino; Yoshihiko Nishio; Satoshi Ugi; Hiroshi Maegawa
MicroRNA-494 regulates mitochondrial biogenesis in skeletal muscle through mitochondrial transcription factor A and Forkhead box j3.
American journal of physiology. Endocrinology and metabolism 2012;303(12):E1419-27.
2012: Shinji Kume; Hiroshi Maegawa; Takashi Uzu; Daisuke Koya
Autophagy: a novel therapeutic target for kidney diseases.
Clinical and experimental nephrology 2012;16(6):827-32.
2012: Takashi Uzu; Keiko Nakao; Satoshi Ugi; Hisazumi Araki; Shin-Ichi Araki; Keiji Isshiki; Atsunori Kashiwagi; Hiromichi Kawai; Shinji Kume; Hiroshi Maegawa
High sodium intake is associated with masked hypertension in Japanese patients with type 2 diabetes and treated hypertension.
American journal of hypertension 2012;25(11):1170-4.
2012: Akira Sekikawa; Chol Shin; Laufey Steingrimsdottir; Bolli Thorsson; Hirotsugu Ueshima; Bradley J Willcox; J David Curb; Jina Choo; Gudny Eiriksdottir; Rhobert W Evans; Akira Fujiyoshi; Melisa E Garcia; Tamara B Harris; Alda M Hauksdottir; Aya Kadota; Lewis H Kuller; Lenore J Launer; Hiroshi Maegawa; Kamal Masaki; Katsuyuki Miura; Vilmundur Gudnason
Serum levels of marine-derived n-3 fatty acids in Icelanders, Japanese, Koreans, and Americans--a descriptive epidemiologic study.
Prostaglandins, leukotrienes, and essential fatty acids 2012;87(1):11-6.
2012: Satoshi Ugi; Hiroshi Maegawa
[Fixed dose of combination of pioglitazone/metformin].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 3():627-32.
2012: Shin-ichi Araki; Satoshi Iimuro; Hideki Ito; Atsunori Kashiwagi; Hiroshi Maegawa; Yoshihiko Nishio; Yasuo Ohashi; Takashi Sakurai; Hiroyuki Umegaki; Takashi Uzu; Atsushi Araki
Factors associated with progression of diabetic nephropathy in Japanese elderly patients with type 2 diabetes: sub-analysis of the Japanese Elderly Diabetes Intervention Trial.
Geriatrics & gerontology international 2012;12 Suppl 1():127-33.
2012: Masahiro Aoyama; Hisazumi Araki; Shin-Ichi Araki; Masami Chin-Kanasaki; Masakazu Haneda; Keiji Isshiki; Atsunori Kashiwagi; Daisuke Koya; Shinji Kume; Hiroshi Maegawa; Takashi Uzu
Fructose induces tubulointerstitial injury in the kidney of mice.
Biochemical and biophysical research communications 2012;419(2):244-9.
2012: Takashi Uzu; Atsushi Yamauchi; Daisuke Koya; Shinji Kume; Hiroshi Maegawa; Shin-Ichi Araki; Masakazu Haneda; Keiji Isshiki; Atsunori Kashiwagi; Yasuo Kida; Ryuichi Kikkawa
The effects of blood pressure control levels on the renoprotection of type 2 diabetic patients without overt proteinuria.
Journal of the American Society of Hypertension : JASH 2012;6(2):124-31.
2012: Naoko Deji; Masakazu Haneda; Keiji Isshiki; Atsunori Kashiwagi; Daisuke Koya; Shinji Kume; Hiroshi Maegawa; Akira Nishiyama; Yuki Tanaka; Hisazumi Araki; Shin-ichi Araki; Masami Chin-Kanasaki; Takashi Uzu
Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension.
Biochemical and biophysical research communications 2012;418(3):559-64.
2012: Takeshi Yoshizaki; Atsunori Kashiwagi; Motoyuki Kondo; Shinji Kume; Chisato Kusunoki; Katsutaro Morino; Yoshihiko Nishio; Osamu Sekine; Satoshi Ugi; Takashi Uzu; Mako Yasuda; Hiroshi Maegawa
Autophagy regulates inflammation in adipocytes.
Biochemical and biophysical research communications 2012;417(1):352-7.
2012: Yuki Tanaka; Takashi Uzu; Keizo Kanasaki; Munehiro Kitada; Shinji Kume; Hiroshi Maegawa; Daisuke Koya
Autophagy as a therapeutic target in diabetic nephropathy.
Experimental diabetes research 2012;2012():628978.
2011: Isamu Yamakawa; Hitoshi Yasuda; Lawrence Chan; Miwako Katagi; Hiromichi Kawai; Hideto Kojima; Hiroshi Maegawa; Jiro Oi; Mitsuru Sanada; Tomoya Terashima; Hiroshi Urabe; Hiroshi Kimura
Inactivation of TNF-α ameliorates diabetic neuropathy in mice.
American journal of physiology. Endocrinology and metabolism 2011;301(5):E844-52.
2011: Tetsuro Koyama; Shinji Kume; Hiroshi Maegawa; Takeshi Sugaya; Toshiro Sugimoto; Shin-ichi Araki; Masami Chin-Kanasaki; Masakazu Haneda; Keiji Isshiki; Atsunori Kashiwagi; Daisuke Koya; Takashi Uzu
SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells.
Free radical biology & medicine 2011;51(6):1258-67.
2011: Takashi Uzu; Shin-ichi Araki; Keiji Isshiki; Hiroshi Maegawa
Furosemide-associated nephrocalcinosis and renal cysts.
Kidney international 2011;80(5):556.
2011: Motoyuki Kondo; Satoshi Ugi; Katsutaro Morino; Tomoya Fuke; Toshiyuki Obata; Takeshi Yoshizaki; Yoshihiko Nishio; Shiro Maeda; Atsunori Kashiwagi; Hiroshi Maegawa
Postprandial activation of protein kinase Cµ regulates the expression of adipocytokines via the transcription factor AP-2β.
International journal of molecular medicine 2011;28(1):95-100.
2011: Itsuko Miyazawa; Shin-ichi Araki; Toshiyuki Obata; Takeshi Yoshizaki; Katsutaro Morino; Aya Kadota; Satoshi Ugi; Hiromichi Kawai; Takashi Uzu; Yoshihiko Nishio; Daisuke Koya; Masakazu Haneda; Atsunori Kashiwagi; Hiroshi Maegawa
Association between serum soluble TNFα receptors and renal dysfunction in type 2 diabetic patients without proteinuria.
Diabetes research and clinical practice 2011;92(2):174-80.
2011: Yuki Tanaka; Shinji Kume; Shin-ichi Araki; Keiji Isshiki; Masami Chin-Kanasaki; Masayoshi Sakaguchi; Toshiro Sugimoto; Daisuke Koya; Masakazu Haneda; Atsunori Kashiwagi; Hiroshi Maegawa; Takashi Uzu
Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis.
Kidney international 2011;79(8):871-82.
2011: Takashi Uzu; Hiroki Yokoyama; Hirofumi Itoh; Daisuke Koya; Atsushi Nakagawa; Makoto Nishizawa; Hiroshi Maegawa; Yukiyo Yokomaku; Shin-Ichi Araki; Atsuko Abiko; Masakazu Haneda
Elevated serum levels of interleukin-18 in patients with overt diabetic nephropathy: effects of miglitol.
Clinical and experimental nephrology 2011;15(1):58-63.
2011: Xu Yang; Shin-ichi Araki; Masami Chin-Kanasaki; Ping Han; Masakazu Haneda; Keiji Isshiki; Atsunori Kashiwagi; Daisuke Koya; Shinji Kume; Detian Li; Hiroshi Maegawa; Yoshihiko Nishio; Takeshi Sugaya; Toshiro Sugimoto; Yuki Tanaka; Takashi Uzu
GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice.
PloS one 2011;6(9):e25271.
2011: Satoshi Ugi; Hiroshi Maegawa; Shiro Maeda
[Role of TFAP2B and WntSB in adipose tissue].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 1():269-74.
2010: Hiroko Nakamura; Wei-Guang Ding; Mitsuru Sanada; Kengo Maeda; Hiromichi Kawai; Hiroshi Maegawa; Hiroshi Matsuura
Presence and functional role of the rapidly activating delayed rectifier K(+) current in left and right atria of adult mice.
European journal of pharmacology 2010;649(1-3):14-22.
2010: Mariko Soumura; Shinji Kume; Keiji Isshiki; Naoko Takeda; Shin-ichi Araki; Yuki Tanaka; Toshiro Sugimoto; Masami Chin-Kanasaki; Yoshihiko Nishio; Masakazu Haneda; Daisuke Koya; Atsunori Kashiwagi; Hiroshi Maegawa; Takashi Uzu
Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell.
Biochemical and biophysical research communications 2010;402(2):265-71.
2010: Atsushi Ishikado; Yoshihiko Nishio; Katsutaro Morino; Satoshi Ugi; Hajime Kondo; Taketoshi Makino; Atsunori Kashiwagi; Hiroshi Maegawa
Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells.
Biochemical and biophysical research communications 2010;402(1):99-104.
2010: Akira Sekikawa; Takashi Kadowaki; J David Curb; Rhobert W Evans; Hiroshi Maegawa; Robert D Abbott; Kim Sutton-Tyrrell; Tomonori Okamura; Chol Shin; Daniel Edmundowicz; Aya Kadota; Jina Choo; Aiman El-Saed; Hirotsugu Ueshima; Lewis H Kuller
Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, white, and Japanese American middle-aged men.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010;30(7):541-8.
2010: Satoshi Ugi; Yoshihiko Nishio; Hiroshi Yamamoto; Kazuhiro Ikeda; Masaaki Kobayashi; Shuichi Tsukada; Motoyuki Kondo; Katsutaro Morino; Toshiyuki Obata; Takeshi Yoshizaki; Takashi Uzu; Hiroyuki Naitoh; Toru Tani; Shiro Maeda; Atsunori Kashiwagi; Hiroshi Maegawa
Relation of the expression of transcriptional factor TFAP2B to that of adipokines in subcutaneous and omental adipose tissues.
Obesity (Silver Spring, Md.) 2010;18(7):1277-82.
2010: Keiko Kondo; Katsutaro Morino; Yoshihiko Nishio; Motoyuki Kondo; Tomoya Fuke; Satoshi Ugi; Hiromi Iwakawa; Atsunori Kashiwagi; Hiroshi Maegawa
Effects of a fish-based diet on the serum adiponectin concentration in young, non-obese, healthy Japanese subjects.
Journal of atherosclerosis and thrombosis 2010;17(6):628-37.
2010: T Fuke; Takeshi Yoshizaki; M Kondo; Katsutaro Morino; Toshiyuki Obata; Satoshi Ugi; Yoshihiko Nishio; Shiro Maeda; Atsunori Kashiwagi; Hiroshi Maegawa
Transcription factor AP-2beta inhibits expression and secretion of leptin, an insulin-sensitizing hormone, in 3T3-L1 adipocytes.
International journal of obesity (2005) 2010;34(4):670-8.
2009: Shin-ichi Araki; Hiroyuki Matsuno; Masakazu Haneda; Daisuke Koya; Yosuke Kanno; Junko Itho; Akio Kishi; Keiji Isshiki; Toshiro Sugimoto; Hiroshi Maegawa; Atsunori Kashiwagi; Takashi Uzu
Correlation between albuminuria and spontaneous platelet microaggregate formation in type 2 diabetic patients.
Diabetes care 2009;32(11):2062-7.
2009: Satoshi Ugi; Kun Shi; Yoshihiko Nishio; Shinya Shimizu; Baoliang Guo; Osamu Sekine; Kazuhiro Ikeda; Katsuya Egawa; Takeshi Yoshizaki; Yoshio Nagai; Daisuke Koya; Tatsuyuki Takada; Ryuzo Torii; Hiroshi Kimura; Atsunori Kashiwagi; Hiroshi Maegawa
Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression and consequent hypertriglyceridaemia.
Journal of biochemistry 2009;146(4):541-7.
2009: Tomonori Okamura; Akira Sekikawa; Takashi Kadowaki; Aiman El-Saed; Robert D Abbott; J David Curb; Daniel Edmundowicz; Yasuyuki Nakamura; Kiyoshi Murata; Atsunori Kashiwagi; Kim Sutton-Tyrrell; Rhobert W Evans; Joseph Zmuda; Hiroshi Maegawa; Atsushi Hozawa; Ken-Ichi Mitsunami; Yoshihiko Nishio; Iva Miljkovic-Gacic; Minoru Horie; Naomi Miyamatsu; Yoshitaka Murakami; Lewis H Kuller; Hirotsugu Ueshima
Cholesteryl ester transfer protein, coronary calcium, and intima-media thickness of the carotid artery in middle-age Japanese men.
The American journal of cardiology 2009;104(6):818-22.
2009: Atsushi Ishikado; Yoshihiko Nishio; Kazuko Yamane; Atsushi Mukose; Katsutaro Morino; Yoko Murakami; Osamu Sekine; Taketoshi Makino; Hiroshi Maegawa; Atsunori Kashiwagi
Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells.
Atherosclerosis 2009;205(2):404-12.
2009: Yasuyuki Nakamura; Akira Sekikawa; Takashi Kadowaki; Aya Kadota; Sayaka Kadowaki; Hiroshi Maegawa; Yoshikuni Kita; Rhobert W Evans; Daniel Edmundowicz; J David Curb; Hirotsugu Ueshima
Visceral and subcutaneous adiposity and adiponectin in middle-aged Japanese men: the ERA JUMP study.
Obesity (Silver Spring, Md.) 2009;17(6):1269-73.
2009: Eiji Suzuki; Toru Yoshimura; Yasushi Omura; Masayoshi Sakaguchi; Yoshihiko Nishio; Hiroshi Maegawa; Akitaka Hisatomi; Kazuma Fujimoto; Jun Takeda; Atsunori Kashiwagi
Higher arterial stiffness, greater peripheral vascular resistance and lower blood flow in lower-leg arteries are associated with long-term hyperglycaemia in type 2 diabetic patients with normal ankle-brachial index.
Diabetes/metabolism research and reviews 2009;25(4):363-9.
2009: Yasushi Omura; Yoshihiko Nishio; Tadashi Takemoto; Chikako Ikeuchi; Osamu Sekine; Katsutaro Morino; Yasuhiro Maeno; Toshiyuki Obata; Satoshi Ugi; Hiroshi Maegawa; Hiroshi Kimura; Atsunori Kashiwagi
SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.
BMB reports 2009;42(4):232-7.
2009: Motoyuki Kondo; Hiroshi Maegawa; Toshiyuki Obata; Satoshi Ugi; Kazuhiro Ikeda; Katsutaro Morino; Yukie Nakai; Yoshihiko Nishio; Shiro Maeda; Atsunori Kashiwagi
Transcription factor activating protein-2beta: a positive regulator of monocyte chemoattractant protein-1 gene expression.
Endocrinology 2009;150(4):1654-61.
2009: Hiroshi Maegawa; Atsunori Kashiwagi
[Obesity as risk for developing diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(2):339-43.
2009: Akio Kishi; Yumiko Kawabata; Satoshi Ugi; Tamaki Iwai; Yuki Tanaka; Takeshi Yoshizaki; Takashi Uzu; Yoshihiko Nishio; Hiroshi Ikegami; Atsunori Kashiwagi; Hiroshi Maegawa
The onset of diabetes in three out of four sisters: a Japanese family with type 1 diabetes. A case report.
Endocrine journal 2009;56(6):767-72.
2008: Toru Yoshimura; Eiji Suzuki; Isamu Ito; Masayoshi Sakaguchi; Takashi Uzu; Yoshihiko Nishio; Hiroshi Maegawa; Shigehiro Morikawa; Toshiro Inubushi; Akitaka Hisatomi; Kazuma Fujimoto; Jun Takeda; Atsunori Kashiwagi
Impaired peripheral circulation in lower-leg arteries caused by higher arterial stiffness and greater vascular resistance associates with nephropathy in type 2 diabetic patients with normal ankle-brachial indices.
Diabetes research and clinical practice 2008;80(3):416-23.
2008: Akira Sekikawa; Hirotsugu Ueshima; Kim Sutton-Tyrrell; Takashi Kadowaki; Aiman El-Saed; Tomonori Okamura; Tomoko Takamiya; Yoshiki Ueno; Rhobert W Evans; Yasuyuki Nakamura; Daniel Edmundowicz; Atsunori Kashiwagi; Hiroshi Maegawa; Lewis H Kuller
Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40 to 49 years between whites in the United States and the Japanese in Japan for the ERA JUMP study.
Metabolism: clinical and experimental 2008;57(2):177-82.
2008: Hiroshi Yamamoto; Hiroshi Tsuchihashi; Hiroya Akabori; Hiroyuki Naitoh; Hiroshi Maegawa; Tohru Tani
Postprandial hyperglycemia after a gastrectomy and the prediabetic state: a comparison between a distal and total gastrectomy.
Surgery today 2008;38(8):685-90.
2007: Kun Shi; Satoshi Ugi; S Shimizu; Osamu Sekine; K Ikeda; Katsuya Egawa; Takeshi Yoshizaki; Yoshio Nagai; Yoshihiko Nishio; Tatsuyuki Takada; Ryuzo Torii; Hiroshi Kimura; Atsunori Kashiwagi; Hiroshi Maegawa
Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression.
Biochemical and biophysical research communications 2007;363(3):626-32.
2007: Yasushi Omura; Satoshi Ugi; Toshiro Sugimoto; Yoshihiko Nishio; Hiroshi Maegawa; Atsunori Kashiwagi
Massive pericardial effusion secondary to Hashimoto's disease.
European journal of internal medicine 2007;18(5):438-40.
2007: Hiroshi Maegawa; Yoshihiko Nishio; Keiko Nakao; Satoshi Ugi; Kendo Maeda; Takashi Uzu; Atsunori Kashiwagi
Short-term low-dosage pioglitazone treatment improves vascular dysfunction in patients with type 2 diabetes.
Endocrine journal 2007;54(4):613-8.
2007: Takashi Uzu; Makoto Sawaguchi; Hiroshi Maegawa; Atsunori Kashiwagi
Reduction of microalbuminuria in patients with type 2 diabetes: the Shiga Microalbuminuria Reduction Trial (SMART).
Diabetes care 2007;30(6):1581-3.
2007: Akira Sekikawa; Hirotsugu Ueshima; Takashi Kadowaki; Aiman El-Saed; Tomonori Okamura; Tomoko Takamiya; Atsunori Kashiwagi; Daniel Edmundowicz; Kiyoshi Murata; Kim Sutton-Tyrrell; Hiroshi Maegawa; Rhobert W Evans; Yoshikuni Kita; Lewis H Kuller
Less subclinical atherosclerosis in Japanese men in Japan than in White men in the United States in the post-World War II birth cohort.
American journal of epidemiology 2007;165(6):617-24.
2007: Y Sato; Yoshihiko Nishio; Osamu Sekine; K Kodama; Yoshio Nagai; Takaaki Nakamura; Hiroshi Maegawa; Atsunori Kashiwagi
Increased expression of CCAAT/enhancer binding protein-beta and -delta and monocyte chemoattractant protein-1 genes in aortas from hyperinsulinaemic rats.
Diabetologia 2007;50(2):481-9.
2007: Tadashi Takemoto; Yoshihiko Nishio; Osamu Sekine; Chikako Ikeuchi; Yoshio Nagai; Yasuhiro Maeno; Hiroshi Maegawa; Hiroshi Kimura; Atsunori Kashiwagi
RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.
FEBS letters 2007;581(2):218-22.
2006: Hiroshi Maegawa; Shiro Maeda
[Role of TFAP2B and Wnt5B in adipose tissue].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():244-8.
2006: Takashi Kadowaki; Akira Sekikawa; Tomonori Okamura; Tomoko Takamiya; Atsunori Kashiwagi; Wahid R Zaky; Hiroshi Maegawa; Aiman El-Saed; Yasuyuki Nakamura; Rhobert W Evans; Daniel Edmundowicz; Yoshikuni Kita; Lewis H Kuller; Hirotsugu Ueshima
Higher levels of adiponectin in American than in Japanese men despite obesity.
Metabolism: clinical and experimental 2006;55(12):1561-3.
2006: Kazuhiro Ikeda; Hiroshi Maegawa; Satoshi Ugi; Yukari Tao; Yoshihiko Nishio; Shuichi Tsukada; Shiro Maeda; Atsunori Kashiwagi
Transcription factor activating enhancer-binding protein-2beta. A negative regulator of adiponectin gene expression.
The Journal of biological chemistry 2006;281(42):31245-53.
2006: Satoshi Nomura; Takaaki Nakamura; Tetsuya Hashimoto; Yoshihiko Nishio; Hiroshi Maegawa; Motoi Kudo; Atsunori Kashiwagi
MafA differentiates rat intestinal cells into insulin-producing cells.
Biochemical and biophysical research communications 2006;349(1):136-43.
2006: Takashi Uzu; Genjiro Kimura; Atsushi Yamauchi; Masami Kanasaki; Keiji Isshiki; Shin-ichi Araki; Toshiro Sugiomoto; Yoshihiko Nishio; Hiroshi Maegawa; Daisuke Koya; Masakazu Haneda; Atsunori Kashiwagi
Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension.
Journal of hypertension 2006;24(8):1627-32.
2006: Toru Yoshimura; Eiji Suzuki; Katsuya Egawa; Yoshihiko Nishio; Hiroshi Maegawa; Shigehiro Morikawa; Toshiro Inubushi; Akitaka Hisatomi; Kazuma Fujimoto; Atsunori Kashiwagi
Low blood flow estimates in lower-leg arteries predict cardiovascular events in Japanese patients with type 2 diabetes with normal ankle-brachial indexes.
Diabetes care 2006;29(8):1884-90.
2006: Tomonori Okamura; Takashi Kadowaki; Akira Sekikawa; Kiyoshi Murata; Naomi Miyamatsu; Yasuyuki Nakamura; Aiman El-Saed; Atsunori Kashiwagi; Hiroshi Maegawa; Yoshihiko Nishio; Tomoko Takamiya; Hideyuki Kanda; Kenichi Mitsunami; Yoshikuni Kita; Daniel Edmundowicz; Shinji Tamaki; Yasuyuki Tsujita; Lewis H Kuller; Hirotsugu Ueshima
Alcohol consumption and coronary artery calcium in middle-aged Japanese men.
The American journal of cardiology 2006;98(2):141-4.
2006: Takashi Kadowaki; Akira Sekikawa; Kiyoshi Murata; Hiroshi Maegawa; Tomoko Takamiya; Tomonori Okamura; Aiman El-Saed; Naomi Miyamatsu; Daniel Edmundowicz; Yoshikuni Kita; Kim Sutton-Tyrrell; Lewis H Kuller; Hirotsugu Ueshima
Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study.
International journal of obesity (2005) 2006;30(7):1163-5.
2006: Yukari Tao; Hiroshi Maegawa; Satoshi Ugi; Kazuhiro Ikeda; Yoshio Nagai; Katsuya Egawa; Takaaki Nakamura; Shuichi Tsukada; Yoshihiko Nishio; Shiro Maeda; Atsunori Kashiwagi
The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3T3-L1 adipocytes.
Endocrinology 2006;147(4):1685-96.
2005: Masanobu Tsuchiya; Eiji Suzuki; Katsuya Egawa; Yoshihiko Nishio; Hiroshi Maegawa; Shigehiro Morikawa; Toshiro Inubushi; Atsunori Kashiwagi
Abnormal peripheral circulation in type 2 diabetic patients with normal ankle-brachial index associates with coronary atherosclerosis, large artery stiffness, and peripheral vascular resistance.
Diabetes research and clinical practice 2005;70(3):253-62.
2005: Ken-ichi Kodama; Yoshihiko Nishio; Osamu Sekine; Yoshinori Sato; Katsuya Egawa; Hiroshi Maegawa; Atsunori Kashiwagi
Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells.
American journal of physiology. Cell physiology 2005;289(3):C582-90.
2005: Hiroshi Maegawa; Atsunori Kashiwagi
[Assessment of microvascular complication in diabetic subjects].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 6():37-42.
2005: Akira Sekikawa; Hirotsugu Ueshima; Wahid R Zaky; Takashi Kadowaki; Daniel Edmundowicz; Tomonori Okamura; Kim Sutton-Tyrrell; Yasuyuki Nakamura; Katsuya Egawa; Hideyuki Kanda; Atsunori Kashiwagi; Yoshiyuki Kita; Hiroshi Maegawa; Kenichi Mitsunami; Kiyoshi Murata; Yoshihiko Nishio; Shinji Tamaki; Yoshiki Ueno; Lewis H Kuller
Much lower prevalence of coronary calcium detected by electron-beam computed tomography among men aged 40-49 in Japan than in the US, despite a less favorable profile of major risk factors.
International journal of epidemiology 2005;34(1):173-9.
2005: Tetsuya Hashimoto; Takaaki Nakamura; Hiroshi Maegawa; Yoshihiko Nishio; Katsuya Egawa; Atsunori Kashiwagi
Regulation of ATP-sensitive potassium channel subunit Kir6.2 expression in rat intestinal insulin-producing progenitor cells.
The Journal of biological chemistry 2005;280(3):1893-900.
2004: Masanobu Tsuchiya; Eiji Suzuki; Katsuya Egawa; Yoshihiko Nishio; Hiroshi Maegawa; Shinji Inoue; Kenichi Mitsunami; Shigehiro Morikawa; Toshiro Inubushi; Atsunori Kashiwagi
Stiffness and impaired blood flow in lower-leg arteries are associated with severity of coronary artery calcification among asymptomatic type 2 diabetic patients.
Diabetes care 2004;27(10):2409-15.
2004: Satoshi Ugi; Takeshi Imamura; Hiroshi Maegawa; Katsuya Egawa; Takeshi Yoshizaki; Kun Shi; Toshiyuki Obata; Yousuke Ebina; Atsunori Kashiwagi; Jerrold M Olefsky
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes.
Molecular and cellular biology 2004;24(19):8778-89.
2004: Ryoko Nagata; Yoshihiko Nishio; Osamu Sekine; Yoshio Nagai; Yasuhiro Maeno; Satoshi Ugi; Hiroshi Maegawa; Atsunori Kashiwagi
Single nucleotide polymorphism (-468 Gly to A) at the promoter region of SREBP-1c associates with genetic defect of fructose-induced hepatic lipogenesis [corrected].
The Journal of biological chemistry 2004;279(28):29031-42.
2004: Kun Shi; Katsuya Egawa; Hiroshi Maegawa; Takaaki Nakamura; Satoshi Ugi; Yoshihiko Nishio; Atsunori Kashiwagi
Protein-tyrosine phosphatase 1B associates with insulin receptor and negatively regulates insulin signaling without receptor internalization.
Journal of biochemistry 2004;136(1):89-96.
2004: Fei Ye; Hiroshi Maegawa; Katsutaro Morino; Atsunori Kashiwagi; Ryuichi Kikkawa; Mingzhi Xie; Zhufang Shen
A simple and sensitive method for glutamine:fructose-6-phosphate amidotransferase assay.
Journal of biochemical and biophysical methods 2004;59(3):201-8.
2004: Takeshi Yoshizaki; Hiroshi Maegawa; Katsuya Egawa; Satoshi Ugi; Yoshihiko Nishio; Takeshi Imamura; Takayasu Kobayashi; Shinri Tamura; Jerrold M Olefsky; Atsunori Kashiwagi
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.
The Journal of biological chemistry 2004;279(21):22715-26.
2003: Shinya Shimizu; Satoshi Ugi; Hiroshi Maegawa; Katsuya Egawa; Yoshihiko Nishio; Takeshi Yoshizaki; Kun Shi; Yoshio Nagai; Katsutaro Morino; Ken-ichi Nemoto; Takaaki Nakamura; Michael Bryer-Ash; Atsunori Kashiwagi
Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression.
The Journal of biological chemistry 2003;278(44):43095-101.
2003: Eiji Suzuki; Katsuya Egawa; Yoshihiko Nishio; Hiroshi Maegawa; Masanobu Tsuchiya; Masakazu Haneda; Hitoshi Yasuda; Shigehiro Morikawa; Toshiro Inubushi; Atsunori Kashiwagi
Prevalence and major risk factors of reduced flow volume in lower extremities with normal ankle-brachial index in Japanese patients with type 2 diabetes.
Diabetes care 2003;26(6):1764-9.
2003: Akio Kishi; Takaaki Nakamura; Yoshihiko Nishio; Hiroshi Maegawa; Atsunori Kashiwagi
Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation.
American journal of physiology. Endocrinology and metabolism 2003;284(4):E830-40.
2002: Shinya Shimizu; Hiroshi Maegawa; Katsuya Egawa; Kun Shi; Michael Bryer-Ash; Atsunori Kashiwagi
Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytes.
Endocrinology 2002;143(12):4563-9.
2002: Katsuya Egawa; Hiroshi Maegawa; Kun Shi; Takaaki Nakamura; Toshiyuki Obata; Takeshi Yoshizaki; Katsutaro Morino; Shinya Shimizu; Yoshihiko Nishio; Eiji Suzuki; Atsunori Kashiwagi
Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes.
The Journal of biological chemistry 2002;277(41):38863-9.
2002: Osamu Sekine; Yoshihiko Nishio; Katsuya Egawa; Takaaki Nakamura; Hiroshi Maegawa; Atsunori Kashiwagi
Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells.
The Journal of biological chemistry 2002;277(39):36631-9.
2002: Hiroshi Maegawa
[Insulin receptor dysfunction and insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():553-8.
2002: Hideto Kojima; Takaaki Nakamura; Yukihiro Fujita; Akio Kishi; Mineko Fujimiya; Syu Yamada; Motoi Kudo; Yoshihiko Nishio; Hiroshi Maegawa; Masakazu Haneda; Hitoshi Yasuda; Itaru Kojima; Masaharu Seno; Norman C W Wong; Ryuichi Kikkawa; Atsunori Kashiwagi
Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin.
Diabetes 2002;51(5):1398-408.
2002: Yoshio Nagai; Yoshihiko Nishio; Takaaki Nakamura; Hiroshi Maegawa; Ryuichi Kikkawa; Atsunori Kashiwagi
Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha.
American journal of physiology. Endocrinology and metabolism 2002;282(5):E1180-90.
2001: Eiji Suzuki; Atsunori Kashiwagi; Yoshihiko Nishio; Katsuya Egawa; S Shimizu; Hiroshi Maegawa; Masakazu Haneda; Hitoshi Yasuda; Shigehiro Morikawa; Toshiro Inubushi; Ryuichi Kikkawa
Increased arterial wall stiffness limits flow volume in the lower extremities in type 2 diabetic patients.
Diabetes care 2001;24(12):2107-14.
2001: Katsutaro Morino; Hiroshi Maegawa; T Fujita; N Takahara; Katsuya Egawa; Atsunori Kashiwagi; Ryuichi Kikkawa
Insulin-induced c-Jun N-terminal kinase activation is negatively regulated by protein kinase C delta.
Endocrinology 2001;142(6):2669-76.
2001: Hiroshi Maegawa; Ryuichi Kikkawa
[Nutritional support for diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 5():667-70.
2001: Takaaki Nakamura; Akio Kishi; Yoshihiko Nishio; Hiroshi Maegawa; K Egawa; Norman C W Wong; Hideto Kojima; Mineko Fujimiya; R Arai; Atsunori Kashiwagi; Ryuichi Kikkawa
Insulin production in a neuroectodermal tumor that expresses islet factor-1, but not pancreatic-duodenal homeobox 1.
The Journal of clinical endocrinology and metabolism 2001;86(4):1795-800.
2001: Katsuya Egawa; Hiroshi Maegawa; Shinya Shimizu; Katsutaro Morino; Yoshihiko Nishio; Michael Bryer-Ash; Anthony T Cheung; Jay K Kolls; Ryuichi Kikkawa; Atsunori Kashiwagi
Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells.
The Journal of biological chemistry 2001;276(13):10207-11.
2000: Eiji Suzuki; Atsunori Kashiwagi; Yoshihiko Nishio; Hideto Kojima; Hiroshi Maegawa; Masakazu Haneda; Hitoshi Yasuda; Shigehiro Morikawa; Toshiro Inubushi; Ryuichi Kikkawa
Usefulness of waveform analysis of popliteal artery in type II diabetic patients using gated magnetic resonance 2D-cine-PC imaging and 31P spectroscopy.
Diabetologia 2000;43(8):1031-8.
2000: Eiji Suzuki; Atsunori Kashiwagi; Hideki Hidaka; Hiroshi Maegawa; Yoshihiko Nishio; Hideto Kojima; Masakazu Haneda; Hitoshi Yasuda; Shigehiro Morikawa; Toshiro Inubushi; Ryuichi Kikkawa
1H- and 31P-magnetic resonance spectroscopy and imaging as a new diagnostic tool to evaluate neuropathic foot ulcers in Type II diabetic patients.
Diabetologia 2000;43(2):165-72.
2000: Hiroshi Maegawa
[Impairments of insulin receptor function in insulin resistant states].
Nihon rinsho. Japanese journal of clinical medicine 2000;58(2):304-9.
1999: Atsunori Kashiwagi; Kazuya Shinozaki; Yoshihiko Nishio; Hiroshi Maegawa; Y Maeno; A Kanazawa; Hideto Kojima; Masakazu Haneda; Hideki Hidaka; Hitoshi Yasuda; Ryuichi Kikkawa
Endothelium-specific activation of NAD(P)H oxidase in aortas of exogenously hyperinsulinemic rats.
The American journal of physiology 1999;277(6 Pt 1):E976-83.
1999: Hiroshi Maegawa; M Hasegawa; S Sugai; Toshiyuki Obata; Satoshi Ugi; Katsutaro Morino; Katsuya Egawa; T Fujita; T Sakamoto; Yoshihiko Nishio; H Kojima; Masakazu Haneda; H Yasuda; Ryuichi Kikkawa; Atsunori Kashiwagi
Expression of a dominant negative SHP-2 in transgenic mice induces insulin resistance.
The Journal of biological chemistry 1999;274(42):30236-43.
1999: Hiroshi Maegawa
[Glucose].
Nihon rinsho. Japanese journal of clinical medicine 1999;57 Suppl():592-4.
1999: Hiroshi Maegawa; K Shi; Hideki Hidaka; N Iwai; Yoshihiko Nishio; K Egawa; Hideto Kojima; Masakazu Haneda; Hitoshi Yasuda; Y Nakamura; M Kinoshita; Ryuichi Kikkawa; Atsunori Kashiwagi
The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic Japanese population.
Diabetes 1999;48(7):1469-72.
1999: Hiroshi Maegawa; Atsunori Kashiwagi
[Molecular mechanism and clinical impact of insulin resistance in type 2 diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(3):539-44.
1999: Hiroshi Maegawa; Toshiyuki Obata; T Shibata; T Fujita; Satoshi Ugi; Katsutaro Morino; Yoshihiko Nishio; Hideto Kojima; Hideki Hidaka; Masakazu Haneda; Hitoshi Yasuda; Ryuichi Kikkawa; Atsunori Kashiwagi
A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle.
Diabetologia 1999;42(2):151-9.
1998: T Fujita; Hiroshi Maegawa; Atsunori Kashiwagi; H Hirai; Ryuichi Kikkawa
Opposite regulation of tyrosine-phosphorylation of p130(Cas) by insulin and insulin-like growth factor I.
Journal of biochemistry 1998;124(6):1111-6.
1998: Yoshihiko Nishio; Atsunori Kashiwagi; H Taki; Kazuya Shinozaki; Y Maeno; Hideto Kojima; Hiroshi Maegawa; Masakazu Haneda; Hideki Hidaka; Hitoshi Yasuda; Kihachiro Horiike; Ryuichi Kikkawa
Altered activities of transcription factors and their related gene expression in cardiac tissues of diabetic rats.
Diabetes 1998;47(8):1318-25.
1998: Hideto Kojima; Hideki Hidaka; K Matsumura; Y Fujita; Yoshihiko Nishio; Hiroshi Maegawa; Masakazu Haneda; Hitoshi Yasuda; M Fujimiya; Ryuichi Kikkawa; Atsunori Kashiwagi
Concerted regulation of early enterocyte differentiation by insulin-like growth factor I, insulin, and transforming growth factor-beta1.
Proceedings of the Association of American Physicians 1998;110(3):197-206.
1998: Toshiyuki Obata; Hiroshi Maegawa; Atsunori Kashiwagi; T S Pillay; Ryuichi Kikkawa
High glucose-induced abnormal epidermal growth factor signaling.
Journal of biochemistry 1998;123(5):813-20.
1997: N Takahara; Atsunori Kashiwagi; Yoshihiko Nishio; N Harada; Hideto Kojima; Hiroshi Maegawa; Hideki Hidaka; Ryuichi Kikkawa
Oxidized lipoproteins found in patients with NIDDM stimulate radical-induced monocyte chemoattractant protein-1 mRNA expression in cultured human endothelial cells.
Diabetologia 1997;40(6):662-70.
1997: Hiroshi Maegawa
[Assessment of insulin resistance by hyperinsulinemic euglycemic clamp].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl 1():248-51.
1997: H Hidaka; H Sugiura; Takaaki Nakamura; Hideto Kojima; M Fujita; N Sugie; H Okabe; Yoshihiko Nishio; Hiroshi Maegawa; Atsunori Kashiwagi; R Kikkawa
beta-Sitosterolemia with generalized eruptive xanthomatosis.
Endocrine journal 1997;44(1):59-64.
1996: Toshiyuki Obata; Atsunori Kashiwagi; Hiroshi Maegawa; Yoshihiko Nishio; Satoshi Ugi; Hideki Hidaka; Ryuichi Kikkawa
Insulin signaling and its regulation of system A amino acid uptake in cultured rat vascular smooth muscle cells.
Circulation research 1996;79(6):1167-76.
1996: Hiroshi Maegawa; Atsunori Kashiwagi; T Fujita; Satoshi Ugi; M Hasegawa; Toshiyuki Obata; Yoshihiko Nishio; Hideto Kojima; Hideki Hidaka; Ryuichi Kikkawa
SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates.
Biochemical and biophysical research communications 1996;228(1):122-7.
1996: Satoshi Ugi; Hiroshi Maegawa; Atsunori Kashiwagi; M Adachi; J M Olefsky; Ryuichi Kikkawa
Expression of dominant negative mutant SHPTP2 attenuates phosphatidylinositol 3'-kinase activity via modulation of phosphorylation of insulin receptor substrate-1.
The Journal of biological chemistry 1996;271(21):12595-602.
1996: N Takahara; Atsunori Kashiwagi; Hiroshi Maegawa; Y Shigeta
Lysophosphatidylcholine stimulates the expression and production of MCP-1 by human vascular endothelial cells.
Metabolism: clinical and experimental 1996;45(5):559-64.
1995: M Iwanishi; Toshiyuki Obata; S Yamada; Hiroshi Maegawa; R Tachikawa-Ide; Satoshi Ugi; M Hasegawa; Hideto Kojima; T Oguni; R Toudo
Clinical and laboratory characteristics in the families with diabetes and a mitochondrial tRNA(LEU(UUR)) gene mutation.
Diabetes research and clinical practice 1995;29(2):75-82.
1995: Hiroshi Maegawa; R Ide; M Hasegawa; Satoshi Ugi; K Egawa; M Iwanishi; Ryuichi Kikkawa; Y Shigeta; Atsunori Kashiwagi
Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities.
The Journal of biological chemistry 1995;270(13):7724-30.
1995: Hiroshi Maegawa; Atsunori Kashiwagi; Y Shigeta
[Obesity as a risk factor for developing non-insulin dependent diabetes mellitus--obesity and insulin resistance].
Nihon Naibunpi Gakkai zasshi 1995;71(2):97-104.
1995: Hiroshi Maegawa; Ryuichi Kikkawa
[Glucose].
Nihon rinsho. Japanese journal of clinical medicine 1995;53 Su Pt 1():527-31.
1995: Y Takagi; Atsunori Kashiwagi; Y Tanaka; Hiroshi Maegawa; Y Shigeta
Insulin-specific activation of S6 kinase and its desensitization in cultured rat vascular smooth muscle cells.
Atherosclerosis 1995;113(1):19-27.
1995: R Ide; Hiroshi Maegawa; Atsunori Kashiwagi; Ryuichi Kikkawa; Y Shigeta
High glucose condition desensitizes insulin action at the levels of receptor kinase.
Endocrine journal 1995;42(1):1-8.
1994: R Ide; Hiroshi Maegawa; Ryuichi Kikkawa; Y Shigeta; Atsunori Kashiwagi
High glucose condition activates protein tyrosine phosphatases and deactivates insulin receptor function in insulin-sensitive rat 1 fibroblasts.
Biochemical and biophysical research communications 1994;201(1):71-7.
1994: Hiroshi Maegawa; Satoshi Ugi; M Adachi; Y Hinoda; Ryuichi Kikkawa; A Yachi; Y Shigeta; Atsunori Kashiwagi
Insulin receptor kinase phosphorylates protein tyrosine phosphatase containing Src homology 2 regions and modulates its PTPase activity in vitro.
Biochemical and biophysical research communications 1994;199(2):780-5.
1994: Satoshi Ugi; Hiroshi Maegawa; J M Olefsky; Y Shigeta; Atsunori Kashiwagi
Src homology 2 domains of protein tyrosine phosphatase are associated in vitro with both the insulin receptor and insulin receptor substrate-1 via different phosphotyrosine motifs.
FEBS letters 1994;340(3):216-20.
1993: Hiroshi Maegawa; R Tachikawa-Ide; Satoshi Ugi; M Iwanishi; K Egawa; Ryuichi Kikkawa; Y Shigeta; Atsunori Kashiwagi
Pioglitazone ameliorates high glucose induced desensitization of insulin receptor kinase in Rat 1 fibroblasts in culture.
Biochemical and biophysical research communications 1993;197(3):1078-82.
1993: Hiroshi Maegawa; Atsunori Kashiwagi; T Haruta; K Egawa; Satoshi Ugi; R Tachikawa-Ide; M Hasegawa; Masashi Kobayashi; Y Shigeta
Co-expression of mutant and normal human insulin receptors in COS 7 cells.
Biochimica et biophysica acta 1993;1216(3):425-30.
1993: Tetsuro Haruta; Yoshimi Takata; M Iwanishi; Hiroshi Maegawa; T Imamura; K Egawa; T Itazu; Masashi Kobayashi
Ala1048-->Asp mutation in the kinase domain of insulin receptor causes defective kinase activity and insulin resistance.
Diabetes 1993;42(12):1837-44.
1993: Hiroshi Maegawa; Satoshi Ugi; O Ishibashi; R Tachikawa-Ide; N Takahara; Y Tanaka; Y Takagi; Ryuichi Kikkawa; Y Shigeta; Atsunori Kashiwagi
Src homology 2 domains of protein tyrosine phosphatase are phosphorylated by insulin receptor kinase and bind to the COOH-terminus of insulin receptors in vitro.
Biochemical and biophysical research communications 1993;194(1):208-14.
1992: K Sakamoto; H Masuzaki; N Fujimura; M Iwanishi; Hiroshi Maegawa; Masashi Kobayashi; Y Shigeta
[A case of Cushing syndrome caused by ACTH producing atypical lung carcinoid tumor].
Nihon Naibunpi Gakkai zasshi 1992;68(8):743-51.
1991: Hiroshi Maegawa; Y Shigeta; K Egawa; Masashi Kobayashi
Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM.
Diabetes 1991;40(7):815-9.
1991: Hiroshi Maegawa; Masashi Kobayashi; Y Shigeta
[Photoreactive insulin].
Nihon rinsho. Japanese journal of clinical medicine 1991;49 Suppl():576-80.
1990: Hiroshi Maegawa; Masashi Kobayashi; K Egawa; D A McClain; J M Olefsky; Y Shigeta
The ligand binding characteristics of a kinase-defective A/K1018 human insulin receptor expressed in Rat 1 fibroblasts.
Biochimica et biophysica acta 1990;1053(2-3):185-8.