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Shyamala Maheswaran

Research Profile

Chemicals & Drugs

Anatomy

Genes & Molecular Sequences

Wilms' Tumor Genes

Disorders

Breast Neoplasms

Physiology

Living Beings

Mouse
Rats

Concepts & Ideas

Zinc Fingers

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Publications

TOP 3
Emre Ozkumur; Sudarshana Sengupta; Lecia V Sequist; Ajay M Shah; Alice T Shaw; Kyle Smith; Philipp S Spuhler; Shannon L Stott; James P Sullivan; David T Ting; Julie Trautwein; John R Walsh; Min Yu; Thomas A Barber; Aditya Bardia; Elena Brachtel; Pin-i Chen; Jordan C Ciciliano; Benjamin L Emmink; Daniel A Haber; Ravi Kapur; Nezihi Murat Karabacak; Anya Kimura; Richard J Lee; David N Louis; Xi Luo; Shyamala Maheswaran; David T Miyamoto; Bailey Morgan; Mehmet Toner
Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells.
Min Yu; Aditya Bardia; Jose Baselga; Elena F Brachtel; Jordan C Ciciliano; Kyle F Concannon; Maria C Donaldson; Daniel A Haber; Steven J Isakoff; Sridhar Ramaswamy; Lecia V Sequist; Dennis Sgroi; Ajay M Shah; Malgorzata E Smas; Shannon L Stott; David T Ting; Mehmet Toner; Marissa N Wells; Ben S Wittner; Shyamala Maheswaran
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.
David T Miyamoto; Sridhar Ramaswamy; Lecia V Sequist; Malgorzata E Smas; Matthew R Smith; Shannon L Stott; David T Ting; Mehmet Toner; Julie Trautwein; Matthew Ulman; Ben S Wittner; Chin-Lee Wu; Neil H Bander; Brian W Brannigan; Richard J Lee; Jenna B Lord; Shyamala Maheswaran; Daniel A Haber
Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.

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All Publications

2013: Emre Ozkumur; Sudarshana Sengupta; Lecia V Sequist; Ajay M Shah; Alice T Shaw; Kyle Smith; Philipp S Spuhler; Shannon L Stott; James P Sullivan; David T Ting; Julie Trautwein; John R Walsh; Min Yu; Thomas A Barber; Aditya Bardia; Elena Brachtel; Pin-i Chen; Jordan C Ciciliano; Benjamin L Emmink; Daniel A Haber; Ravi Kapur; Nezihi Murat Karabacak; Anya Kimura; Richard J Lee; David N Louis; Xi Luo; Shyamala Maheswaran; David T Miyamoto; Bailey Morgan; Mehmet Toner
Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells.
Science translational medicine 2013;5(179):179ra47.
2013: Min Yu; Aditya Bardia; Jose Baselga; Elena F Brachtel; Jordan C Ciciliano; Kyle F Concannon; Maria C Donaldson; Daniel A Haber; Steven J Isakoff; Sridhar Ramaswamy; Lecia V Sequist; Dennis Sgroi; Ajay M Shah; Malgorzata E Smas; Shannon L Stott; David T Ting; Mehmet Toner; Marissa N Wells; Ben S Wittner; Shyamala Maheswaran
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.
Science (New York, N.Y.) 2013;339(6119):580-4.
2012: David T Miyamoto; Sridhar Ramaswamy; Lecia V Sequist; Malgorzata E Smas; Matthew R Smith; Shannon L Stott; David T Ting; Mehmet Toner; Julie Trautwein; Matthew Ulman; Ben S Wittner; Chin-Lee Wu; Neil H Bander; Brian W Brannigan; Richard J Lee; Jenna B Lord; Shyamala Maheswaran; Daniel A Haber
Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.
Cancer discovery 2012;2(11):995-1003.
2012: Min Yu; Brinda Alagesan; Nabeel Bardeesy; Brian W Brannigan; Jordan C Ciciliano; Gianmarco Contino; Anna J Gilman; Shyamala Maheswaran; Patrice M Milos; Fatih Ozsolak; Suchismita Paul; Sridhar Ramaswamy; David P Ryan; Lecia V Sequist; Malgorzata E Smas; Shannon L Stott; David T Ting; Mehmet Toner; Matthew J Ulman; Daniel Winokur; Ben S Wittner; Kristina Xega; Daniel A Haber
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.
Nature 2012;487(7408):510-3.
2012: Hirohito Seki; Maiko Takahashi; Shyamala Maheswaran; Makio Mukai; Michio Sakata; Tetsu Hayashida; Shigemichi Hirose; Hiromitsu Jinno; Yuko Kitagawa
HOXB9 expression promoting tumor cell proliferation and angiogenesis is associated with clinical outcomes in breast cancer patients.
Annals of surgical oncology 2012;19(6):1831-40.
2012: Ajay M Shah; Shannon L Stott; Matthew Ulman; Min Yu; Jordan Ciciliano; Daniel A Haber; Kenneth Kotz; Shyamala Maheswaran; Zev Nakamura; Mehmet Toner
Biopolymer system for cell recovery from microfluidic cell capture devices.
Analytical chemistry 2012;84(8):3682-8.
2012: Naokazu Chiba; Valentine Comaills; Daniel A Haber; Tetsu Hayashida; Elena F Brachtel; Toshiyuki Shimada; Bunsyo Shiotani; Ken Tajima; Fumiyuki Takahashi; Maria d M Vivanco; Henning Willers; Daniel Winokur; Lee Zou; Shyamala Maheswaran
Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):2760-5.
2011: F Takahashi; M Takahashi; Elena F Brachtel; N Chiba; E J Edelman; T Hayashida; H Moriyama; S Ramaswamy; T Shimada; K Tajima; Shyamala Maheswaran
Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB/HER inhibitor lapatinib.
Oncogene 2011;30(27):3084-95.
2011: Min Yu; Shannon Stott; Mehmet Toner; Shyamala Maheswaran; Daniel A Haber
Circulating tumor cells: approaches to isolation and characterization.
The Journal of cell biology 2011;192(3):373-82.
2011: David T Ting; Doron Lipson; Suchismita Paul; Brian W Brannigan; Sara Akhavanfard; Erik J Coffman; Gianmarco Contino; Vikram Deshpande; A John Iafrate; Stan Letovsky; Miguel N Rivera; Nabeel Bardeesy; Shyamala Maheswaran; Daniel A Haber
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.
Science (New York, N.Y.) 2011;331(6017):593-6.
2011: Chuanwei Yang; Tetsu Hayashida; Nicole Forster; Cuiqi Li; Dejun Shen; Shyamala Maheswaran; L Chen; Karen S Anderson; Leif W Ellisen; Dennis C Sgroi; Emmett V Schmidt
The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers.
Cancer research 2011;71(3):937-45.
2010: Shannon L Stott; Chia-Hsien Hsu; Dina Tsukrov; Min Yu; David T Miyamoto; Belinda A Waltman; S Michael Rothenberg; Ajay M Shah; Malgorzata E Smas; George K Korir; Frederick P Floyd; Anna J Gilman; Jenna B Lord; Daniel Winokur; Simeon Springer; daniel irimia; Sunitha Nagrath; Lecia V Sequist; Richard J Lee; Kurt J Isselbacher; Shyamala Maheswaran; Daniel A Haber; Mehmet Toner
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(43):18392-7.
2010: Sreenath V Sharma; Diana Y Lee; Bihua Li; Margaret P Quinlan; Fumiyuki Takahashi; Shyamala Maheswaran; Ultan McDermott; Nancy Azizian; Lee Zou; Michael A Fischbach; Kwok-Kin Wong; Kathleyn Brandstetter; Ben Wittner; Sridhar Ramaswamy; Marie Classon; Jeffrey Settleman
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.
Cell 2010;141(1):69-80.
2010: Shannon L Stott; Richard J Lee; Sunitha Nagrath; Min Yu; David T Miyamoto; Lindsey Ulkus; Elizabeth J Inserra; Matthew Ulman; Simeon Springer; Zev Nakamura; Alessandra L Moore; Dina Tsukrov; Maria E Kempner; Douglas M Dahl; Chin-Lee Wu; A John Iafrate; Matthew R Smith; Ronald G Tompkins; Lecia V Sequist; Mehmet Toner; Daniel A Haber; Shyamala Maheswaran
Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer.
Science translational medicine 2010;2(25):25ra23.
2010: Shyamala Maheswaran; Daniel A Haber
Circulating tumor cells: a window into cancer biology and metastasis.
Current opinion in genetics & development 2010;20(1):96-9.
2010: Tetsu Hayashida; Fumiyuki Takahashi; Naokazu Chiba; Elena Brachtel; Motomi Takahashi; Nadia Godin-Heymann; Kenneth W Gross; Maria d M Vivanco; Vasuki Wijendran; Toshihiro Shioda; Dennis C Sgroi; Patricia K Donahoe; Shyamala Maheswaran
HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(3):1100-5.
2009: Min Yu; Gromoslaw A Smolen; Jianmin Zhang; Ben Wittner; Benjamin J Schott; Elena Brachtel; Sridhar Ramaswamy; Shyamala Maheswaran; Daniel A Haber
A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression.
Genes & development 2009;23(15):1737-42.
2009: Ultan McDermott; Rachel Y Ames; A John Iafrate; Shyamala Maheswaran; Hannah Stubbs; Patricia Greninger; Kaitlin McCutcheon; Randy Milano; Angela Tam; Diana Y Lee; Laury Lucien; Brian W Brannigan; Lindsey Ulkus; Xiao-Jun Ma; Mark G Erlander; Daniel A Haber; Sreenath V Sharma; Jeffrey Settleman
Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors.
Cancer research 2009;69(9):3937-46.
2008: Shyamala Maheswaran; Lecia V Sequist; Sunitha Nagrath; Lindsey Ulkus; Brian Brannigan; Chey V Collura; Elizabeth Inserra; Sven Diederichs; A John Iafrate; Daphne W Bell; Subba R Digumarthy; Alona Muzikansky; daniel irimia; Jeffrey Settleman; Ronald G Tompkins; Thomas J Lynch; Mehmet Toner; Daniel A Haber
Detection of mutations in EGFR in circulating lung-cancer cells.
The New England journal of medicine 2008;359(4):366-77.
2008: Ultan McDermott; A John Iafrate; Nathanael S Gray; Toshi Shioda; Marie Classon; Shyamala Maheswaran; Wenjun Zhou; Hwan Geun Choi; Shannon L Smith; Lori Dowell; Lindsey Ulkus; Georgiana Kuhlmann; Patricia Greninger; James G Christensen; Daniel A Haber; Jeffrey Settleman
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.
Cancer research 2008;68(9):3389-95.
2008: Nadia Godin-Heymann; Lindsey Ulkus; Brian W Brannigan; Ultan McDermott; Jennifer Lamb; Shyamala Maheswaran; Jeffrey Settleman; Daniel A Haber
The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor.
Molecular cancer therapeutics 2008;7(4):874-9.
2007: Sunitha Nagrath; Lecia V Sequist; Shyamala Maheswaran; Daphne W Bell; daniel irimia; Lindsey Ulkus; Matthew R Smith; Eunice L Kwak; Subba Digumarthy; Alona Muzikansky; Paula Ryan; Ulysses J Balis; Ronald G Tompkins; Daniel A Haber; Mehmet Toner
Isolation of rare circulating tumour cells in cancer patients by microchip technology.
Nature 2007;450(7173):1235-9.
2007: Ultan McDermott; Sreenath V Sharma; Lori Dowell; Patricia Greninger; Clara Montagut; Jennifer Lamb; Heidi Archibald; Raul Raudales; Angela Tam; Diana Lee; S Michael Rothenberg; Jeffrey G Supko; Raffaella Sordella; Lindsey Ulkus; A John Iafrate; Shyamala Maheswaran; Ching-Ni Njauw; Hensin Tsao; Lisa Drew; Jeff H Hanke; Xiao-Jun Ma; Mark G Erlander; Nathanael S Gray; Daniel A Haber; Jeffrey Settleman
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19936-41.
2007: Vandana Gupta; Giminna Yeo; Hirofumi Kawakubo; Vivek Rangnekar; Preethi Ramaswamy; Tetsu Hayashida; David T MacLaughlin; Patricia K Donahoe; Shyamala Maheswaran
Mullerian-inhibiting substance induces Gro-beta expression in breast cancer cells through a nuclear factor-kappaB-dependent and Smad1-dependent mechanism.
Cancer research 2007;67(6):2747-56.
2006: Trinh T Tran; Dorry L Segev; Vandana Gupta; Hirofumi Kawakubo; Giminna Yeo; Patricia K Donahoe; Shyamala Maheswaran
Mullerian inhibiting substance regulates androgen-induced gene expression and growth in prostate cancer cells through a nuclear factor-kappaB-dependent Smad-independent mechanism.
Molecular endocrinology (Baltimore, Md.) 2006;20(10):2382-91.
2006: Hirofumi Kawakubo; Elena F Brachtel; Tetsu Hayashida; Giminna Yeo; Joshua Kish; Alona Muzikansky; Paul D Walden; Shyamala Maheswaran
Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein.
Cancer research 2006;66(14):7075-82.
2005: Vandana Gupta; Jennifer L Carey; Hirofumi Kawakubo; Alona Muzikansky; Jeffrey E Green; Patricia K Donahoe; David T MacLaughlin; Shyamala Maheswaran
Mullerian inhibiting substance suppresses tumor growth in the C3(1)T antigen transgenic mouse mammary carcinoma model.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3219-24.
2004: Hirofumi Kawakubo; Jennifer L Carey; Elena F Brachtel; Vandana Gupta; Jeffrey E Green; Paul D Walden; Shyamala Maheswaran
Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer.
Oncogene 2004;23(50):8310-9.
2004: Vandana Gupta; D P Harkin; Hirofumi Kawakubo; Shyamala Maheswaran
Transforming Growth Factor-beta superfamily: evaluation as breast cancer biomarkers and preventive agents.
Current cancer drug targets 2004;4(2):165-82.
2004: Jennifer L Carey; Laura M Sasur; Hirofumi Kawakubo; Vandana Gupta; Benjamin Christian; Paul M Bailey; Shyamala Maheswaran
Mutually antagonistic effects of androgen and activin in the regulation of prostate cancer cell growth.
Molecular endocrinology (Baltimore, Md.) 2004;18(3):696-707.
2003: Thanh U Barbie; David A Barbie; David T MacLaughlin; Shyamala Maheswaran; Patricia K Donahoe
Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15601-6.
2003: Yasunori Hoshiya; Vandana Gupta; Hirofumi Kawakubo; Elena F Brachtel; Jennifer L Carey; Laura M Sasur; Andrew Scott; Patricia K Donahoe; Shyamala Maheswaran
Mullerian inhibiting substance promotes interferon gamma-induced gene expression and apoptosis in breast cancer cells.
The Journal of biological chemistry 2003;278(51):51703-12.
2003: Yasunori Hoshiya; Vandana Gupta; Dorry L Segev; Makiko Hoshiya; Jennifer L Carey; Laura M Sasur; Trinh T Tran; Thanh U Ha; Shyamala Maheswaran
Mullerian Inhibiting Substance induces NFkB signaling in breast and prostate cancer cells.
Molecular and cellular endocrinology 2003;211(1-2):43-9.
2003: Patricia K Donahoe; Trent Clarke; Jose Teixeira; Shyamala Maheswaran; David T MacLaughlin
Enhanced purification and production of Müllerian inhibiting substance for therapeutic applications.
Molecular and cellular endocrinology 2003;211(1-2):37-42.
2002: Dorry L Segev; Yasunori Hoshiya; Makiko Hoshiya; Trinh T Tran; Jennifer L Carey; Antonia E Stephen; David T MacLaughlin; Patricia K Donahoe; Shyamala Maheswaran
Mullerian-inhibiting substance regulates NF-kappa B signaling in the prostate in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):239-44.
2001: Jose Teixeira; Shyamala Maheswaran; Patricia K Donahoe
Müllerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications.
Endocrine reviews 2001;22(5):657-74.
2001: Paul B Mullan; Jennifer E Quinn; Paula M Gilmore; Stewart McWilliams; Heather N Andrews; C Gervin; Nuala McCabe; S McKenna; P White; Y H Song; Shyamala Maheswaran; E Liu; Daniel A Haber; Patrick G Johnston; D Paul Harkin
BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents.
Oncogene 2001;20(43):6123-31.
2001: Dorry L Segev; Yasunori Hoshiya; Antonia E Stephen; Makiko Hoshiya; Trinh T Tran; David T MacLaughlin; Patricia K Donahoe; Shyamala Maheswaran
Mullerian inhibiting substance regulates NFkappaB signaling and growth of mammary epithelial cells in vivo.
The Journal of biological chemistry 2001;276(29):26799-806.
2000: Thanh U Ha; Dorry L Segev; David A Barbie; Peter T Masiakos; Trinh T Tran; David Dombkowski; M Glander; TR Clarke; Hans Lorenzo; Patricia K Donahoe; Shyamala Maheswaran
Mullerian inhibiting substance inhibits ovarian cell growth through an Rb-independent mechanism.
The Journal of biological chemistry 2000;275(47):37101-9.
2000: Dorry L Segev; Thanh U Ha; Trinh T Tran; M Kenneally; P Harkin; M Jung; David T MacLaughlin; Patricia K Donahoe; Shyamala Maheswaran
Mullerian inhibiting substance inhibits breast cancer cell growth through an NFkappa B-mediated pathway.
The Journal of biological chemistry 2000;275(37):28371-9.
1999: Peter T Masiakos; David T MacLaughlin; Shyamala Maheswaran; Jose Teixeira; Arlan F Fuller; P C Shah; DJ Kehas; M K Kenneally; David Dombkowski; Thanh U Ha; Frederic Preffer; Patricia K Donahoe
Human ovarian cancer, cell lines, and primary ascites cells express the human Mullerian inhibiting substance (MIS) type II receptor, bind, and are responsive to MIS.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3488-99.
1999: D Paul Harkin; J M Bean; D Miklos; Y H Song; Vivi Truong; C Englert; F C Christians; Leif W Ellisen; Shyamala Maheswaran; Jonathan D Oliner; Daniel A Haber
Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.
Cell 1999;97(5):575-86.
1998: Shyamala Maheswaran; C Englert; Sean B Lee; R M Ezzel; Jeffrey Settleman; Daniel A Haber
E1B 55K sequesters WT1 along with p53 within a cytoplasmic body in adenovirus-transformed kidney cells.
Oncogene 1998;16(16):2041-50.
1998: Shyamala Maheswaran; C Englert; G Zheng; Sean B Lee; J Wong; D Paul Harkin; J Bean; Robert Ezzell; A J Garvin; Robert T McCluskey; James A DeCaprio; Daniel A Haber
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.
Genes & development 1998;12(8):1108-20.
1997: Sean B Lee; KA Kolquist; K Nichols; C Englert; Shyamala Maheswaran; Marc Ladanyi; William L Gerald; Daniel A Haber
The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour.
Nature genetics 1997;17(3):309-13.
1997: C Englert; Shyamala Maheswaran; A J Garvin; Jordan A Kreidberg; Daniel A Haber
Induction of p21 by the Wilms' tumor suppressor gene WT1.
Cancer research 1997;57(8):1429-34.
1996: Daniel A Haber; C Englert; Shyamala Maheswaran
Functional properties of WT1.
Medical and pediatric oncology 1996;27(5):453-5.
1995: C Englert; Marc Vidal; Shyamala Maheswaran; Y Ge; Robert Ezzell; Kurt J Isselbacher; Daniel A Haber
Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):11960-4.
1995: C Englert; X Hou; Shyamala Maheswaran; P Bennett; C Ngwu; Gian G Re; A Julian Garvin; M R Rosner; Daniel A Haber
WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.
The EMBO journal 1995;14(19):4662-75.
1995: Shyamala Maheswaran; C Englert; P Bennett; G Heinrich; Daniel A Haber
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.
Genes & development 1995;9(17):2143-56.
1993: Daniel A Haber; S Park; Shyamala Maheswaran; C Englert; Gian G Re; Debra J Hazen-Martin; Donald A Sens; A Julian Garvin
WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.
Science (New York, N.Y.) 1993;262(5142):2057-9.
1993: S Park; Martin Schalling; A Bernard; Shyamala Maheswaran; G C Shipley; D Roberts; J Fletcher; R Shipman; J Rheinwald; George D Demetri
The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma.
Nature genetics 1993;4(4):415-20.
1993: Shyamala Maheswaran; S Park; A Bernard; J F Morris; F J Rauscher; David E Hill; Daniel A Haber
Physical and functional interaction between WT1 and p53 proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5100-4.