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Robert Mahley

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Turkey

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Co-Publications
Name
47
Weisgraber, Karl
29
Huang, Yadong
29
Innerarity, Thomas
23
Rall, SC
22
Bersot, Thomas
19
Ji, Zhong-Sheng
17
Pitas, Robert
10
Taylor, John
10
Grundy, Scott
9
Sanan, David
8
Brecht, Walter
8
Bellosta, Stefano
7
Mucke, Lennart
7
Hui, David
6
Xu, Qin

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Publications

TOP 3
Mahley Robert W; Huang Yadong
Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches.
Ling Hua; Waterworth Dawn M; Stirnadel Heide A; Pollin Toni I; Barter Philip J; Kesäniemi Y Antero; Mahley Robert W; McPherson Ruth; Waeber Gérard; Bersot Thomas P; Cohen Jonathan C; Grundy Scott M; Mooser Vincent E; Mitchell Braxton D
Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.
Mahley Robert W; Weisgraber Karl H; Huang Yadong
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

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All Publications

2009: Mahley Robert W; Huang Yadong
Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches.
Annals of neurology 2009;65(6):623-5.
2009: Ling Hua; Waterworth Dawn M; Stirnadel Heide A; Pollin Toni I; Barter Philip J; Kesäniemi Y Antero; Mahley Robert W; McPherson Ruth; Waeber Gérard; Bersot Thomas P; Cohen Jonathan C; Grundy Scott M; Mooser Vincent E; Mitchell Braxton D
Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.
Obesity (Silver Spring, Md.) 2009;17(4):737-44.
2009: Mahley Robert W; Weisgraber Karl H; Huang Yadong
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.
Journal of lipid research 2009;50 Suppl():S183-8.
2008: Tanyolaç Sinan; Mahley Robert W; Hodoglugil Ugur; Goldfine Ira D
Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.
Obesity (Silver Spring, Md.) 2008;16(11):2468-71.
2008: Burt Trevor D; Agan Brian K; Marconi Vincent C; He Weijing; Kulkarni Hemant; Mold Jeffrey E; Cavrois Marielle; Huang Yadong; Mahley Robert W; Dolan Matthew J; McCune Joseph M; Ahuja Sunil K
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8718-23.
2008: Sandhu Manjinder S; Waterworth Dawn M; Debenham Sally L; Wheeler Eleanor; Papadakis Konstantinos; Zhao Jing Hua; Song Kijoung; Yuan Xin; Johnson Toby; Ashford Sofie; Inouye Michael; Luben Robert; Sims Matthew; Hadley David; McArdle Wendy; Barter Philip; Kesäniemi Y Antero; Mahley Robert W; McPherson Ruth; Grundy Scott M; Bingham Sheila A; Khaw Kay-Tee; Loos Ruth J F; Waeber Gérard; Barroso Inês; Strachan David P; Deloukas Panagiotis; Vollenweider Peter; Wareham Nicholas J; Mooser Vincent
LDL-cholesterol concentrations: a genome-wide association study.
Lancet 2008;371(9611):483-91.
2008: Brodbeck Jens; Balestra Maureen E; Saunders Ann M; Roses Allen D; Mahley Robert W; Huang Yadong
Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(4):1343-6.
2007: Mahley Robert W; Huang Yadong; Weisgraber Karl H
Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease.
Current Alzheimer research 2007;4(5):537-40.
2007: Barter Philip; McPherson Y Ruth; Song Kijoung; Kesäniemi Y Antero; Mahley Robert; Waeber Gérard; Bersot Thomas; Mooser Vincent; Waterworth Dawn; Grundy Scott M
Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia.
The Journal of clinical endocrinology and metabolism 2007;92(6):2041-5.
2007: Mahley Robert W; Huang Yadong
Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing.
The Journal of clinical investigation 2007;117(1):94-8.
2006: Safar Jiri G; Wille Holger; Geschwind Michael D; Deering Camille; Latawiec Diane; Serban Ana; King David J; Legname Giuseppe; Weisgraber Karl H; Mahley Robert W; Miller Bruce L; Dearmond Stephen J; Prusiner Stanley B
Human prions and plasma lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11312-7.
2006: Xu Qin; Bernardo Aubrey; Walker David; Kanegawa Tiffany; Mahley Robert W; Huang Yadong
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(19):4985-94.
2006: Mahley Robert W; Huang Yadong; Weisgraber Karl H
Putting cholesterol in its place: apoE and reverse cholesterol transport.
The Journal of clinical investigation 2006;116(5):1226-9.
2006: Huang Yadong; Mahley Robert W
Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(2):71-3.
2006: Mahley Robert W; Weisgraber Karl H; Huang Yadong
Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5644-51.
2006: Mahley Robert W; Bersot Thomas P
High density lipoprotein cholesterol in coronary artery patients: is it as low as expected?
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 2006;6(1):94-6; author reply 96.
2006: Hodoglugil Ugur; Mahley Robert W
Smoking and obesity make a bad problem worse: genetics and lifestyle affect high density lipoprotein levels in Turks.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 2006;6(1):60-7.
2006: Ji Zhong-Sheng; Müllendorff Karin; Cheng Irene H; Miranda R Dennis; Huang Yadong; Mahley Robert W
Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.
The Journal of biological chemistry 2006;281(5):2683-92.
2006: Hodoglugil Ugur; Tanyolaç Sinan; Williamson David W; Huang Yadong; Mahley Robert W
Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.
Journal of lipid research 2006;47(1):144-53.
2006: Mahley R W; Huang Y
Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.
Acta neurologica Scandinavica. Supplementum 2006;185():8-14.
2005: Chang Shengjun; ran Ma Tian; Miranda R Dennis; Balestra Maureen E; Mahley Robert W; Huang Yadong
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18694-9.
2005: Ye Shiming; Huang Yadong; Müllendorff Karin; Dong Liming; Giedt Gretchen; Meng Elaine C; Cohen Fred E; Kuntz Irwin D; Weisgraber Karl H; Mahley Robert W
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18700-5.
2005: Hodoglugil Ugur; Williamson David W; Huang Yadong; Mahley Robert W
Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks.
Atherosclerosis 2005;183(2):199-212.
2005: Yu Yi; Wyszynski Diego F; Waterworth Dawn M; Wilton Steven D; Barter Philip J; Kesäniemi Y Antero; Mahley Robert W; McPherson Ruth; Waeber Gérard; Bersot Thomas P; Ma Qianli; Sharma Sanjay S; Montgomery Douglas S; Middleton Lefkos T; Sundseth Scott S; Mooser Vincent; Grundy Scott M; Farrer Lindsay A
Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia.
Journal of lipid research 2005;46(10):2202-13.
2005: Mahley Robert W; Can Selçuk; Ozbayrakçi Sinan; Bersot Thomas P; Tanir Sibel; Palaoglu K Erhan; Pépin Guy M
Modulation of high-density lipoproteins in a population in istanbul, Turkey, with low levels of high-density lipoproteins.
The American journal of cardiology 2005;96(4):547-55.
2005: Hodoglugil U; Williamson D W; Huang Y; Mahley R W
An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks.
Clinical genetics 2005;68(2):118-27.
2005: Wyszynski Diego F; Waterworth Dawn M; Barter Philip J; Cohen Jonathan; Kesäniemi Y Antero; Mahley Robert W; McPherson Ruth; Waeber Gérard; Bersot Thomas P; Sharma Sanjay S; Nolan Vikki; Middleton Lefkos T; Sundseth Scott S; Farrer Lindsay A; Mooser Vincent; Grundy Scott M
Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project).
The American journal of cardiology 2005;95(2):194-8.
2004: Harris Faith M; Brecht Walter J; Xu Qin; Mahley Robert W; Huang Yadong
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
The Journal of biological chemistry 2004;279(43):44795-801.
2004: Xu Qin; Brecht Walter J; Weisgraber Karl H; Mahley Robert W; Huang Yadong
Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.
The Journal of biological chemistry 2004;279(24):25511-6.
2004: Brecht Walter J; Harris Faith M; Chang Shengjun; Tesseur Ina; Yu Gui-Qiu; Xu Qin; Dee Fish Jo; Wyss-Coray Tony; Buttini Manuel; Mucke Lennart; Mahley Robert W; Huang Yadong
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(10):2527-34.
2004: Harris Faith M; Tesseur Ina; Brecht Walter J; Xu Qin; Mullendorff Karin; Chang Shengjun; Wyss-Coray Tony; Mahley Robert W; Huang Yadong
Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.
The Journal of biological chemistry 2004;279(5):3862-8.
2004: Huang Yadong; Weisgraber Karl H; Mucke Lennart; Mahley Robert W
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.
Journal of molecular neuroscience : MN 2004;23(3):189-204.
2003: Bersot Thomas P; Pépin Guy M; Mahley Robert W
Risk determination of dyslipidemia in populations characterized by low levels of high-density lipoprotein cholesterol.
American heart journal 2003;146(6):1052-9.
2003: Harris Faith M; Brecht Walter J; Xu Qin; Tesseur Ina; Kekonius Lisa; Wyss-Coray Tony; Fish Jo Dee; Masliah Eliezer; Hopkins Paul C; Scearce-Levie Kimberly; Weisgraber Karl H; Mucke Lennart; Mahley Robert W; Huang Yadong
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10966-71.
2002: Bersot Thomas P; Palaoglu K Erhan; Mahley Robert W
Managing dyslipidemia in Turkey: suggested guidelines for a population characterized by low levels of high density lipoprotein cholesterol.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 2002;2(4):315-22.
2002: Ludwig Erwin H; Mahley R W; Palaoglu E; Ozbayrakçi S; Balestra M E; Borecki I B; Innerarity T L; Farese R V
DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women.
Clinical genetics 2002;62(1):68-73.
2002: Ji Zhong-Sheng; Miranda R Dennis; Newhouse Yvonne M; Weisgraber Karl H; Huang Yadong; Mahley Robert W
Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.
The Journal of biological chemistry 2002;277(24):21821-8.
2002: Shohet Ralph V; Vega Gloria L; Bersot Thomas P; Mahley Robert W; Grundy Scott M; Guerra Rudy; Cohen Jonathan C
Sources of variability in genetic association studies: insights from the analysis of hepatic lipase (LIPC).
Human mutation 2002;19(5):536-42.
2001: Mahley R W; Arslan P; Pekcan G; Pépin G M; Agaçdiken A; Karaagoglu N; Rakicioglu N; Nursal B; Dayanikli P; Palaoglu K E; Bersot T P
Plasma lipids in Turkish children: impact of puberty, socioeconomic status, and nutrition on plasma cholesterol and HDL.
Journal of lipid research 2001;42(12):1996-2006.
2001: Huang Y; Liu X Q; Wyss-Coray T; Brecht W J; Sanan D A; Mahley R W
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8838-43.
2001: Dichek H L; Johnson S M; Akeefe H; Lo G T; Sage E; Yap C E; Mahley R W
Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice.
Journal of lipid research 2001;42(2):201-10.
2000: Nguyen T T; Kruckeberg K E; O'Brien J F; Ji Z S; Karnes P S; Crotty T B; Hay I D; Mahley R W; O'Brien T
Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)].
The Journal of clinical endocrinology and metabolism 2000;85(11):4354-8.
2000: Mahley R W; Pépin J; Palaoglu K E; Malloy M J; Kane J P; Bersot T P
Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase. High density lipoprotein characterization and gender-specific effects of apolipoprotein e genotype.
Journal of lipid research 2000;41(8):1290-301.
2000: Raber J; Wong D; Yu G Q; Buttini M; Mahley R W; Pitas R E; Mucke L
Apolipoprotein E and cognitive performance.
Nature 2000;404(6776):352-4.
2000: Mahley R W; Rall S C
Apolipoprotein E: far more than a lipid transport protein.
Annual review of genomics and human genetics 2000;1():507-37.
2000: Buttini M; Akeefe H; Lin C; Mahley R W; Pitas R E; Wyss-Coray T; Mucke L
Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease.
Neuroscience 2000;97(2):207-10.
1999: Huang Y; Ji Z S; Brecht W J; Rall S C; Taylor J M; Mahley R W
Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(12):2952-9.
1999: Mahley R W; Huang Y; Rall S C
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.
Journal of lipid research 1999;40(11):1933-49.
1999: Mahley R W; Rall S C
Is epsilon4 the ancestral human apoE allele?
Neurobiology of aging 1999;20(4):429-30.
1999: Mahley R W; Huang Y
Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond.
Current opinion in lipidology 1999;10(3):207-17.
1999: Buttini M; Orth M; Bellosta S; Akeefe H; Pitas R E; Wyss-Coray T; Mucke L; Mahley R W
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(12):4867-80.
1999: Bersot T P; Vega G L; Grundy S M; Palaoglu K E; Atagündüz P; Ozbayrakçi S; Gökdemir O; Mahley R W
Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population.
Journal of lipid research 1999;40(3):432-8.
1999: Mahley R W; Ji Z S
Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E.
Journal of lipid research 1999;40(1):1-16.
1998: Huang Y; Liu X Q; Rall S C; Taylor J M; von Eckardstein A; Assmann G; Mahley R W
Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia.
The Journal of biological chemistry 1998;273(41):26388-93.
1998: Raber J; Wong D; Buttini M; Orth M; Bellosta S; Pitas R E; Mahley R W; Mucke L
Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10914-9.
1998: Vega G L; Gao J; Bersot T P; Mahley R W; Verstraete R; Grundy S M; White A; Cohen J C
The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity.
Journal of lipid research 1998;39(7):1520-4.
1998: Huang Y; Liu X Q; Rall S C; Mahley R W
Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins.
The Journal of biological chemistry 1998;273(28):17483-90.
1998: Zhu Y; Bellosta S; Langer C; Bernini F; Pitas R E; Mahley R W; Assmann G; von Eckardstein A
Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7585-90.
1998: Pitas R E; Ji Z S; Weisgraber K H; Mahley R W
Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E.
Biochemical Society transactions 1998;26(2):257-62.
1998: Fan J; Ji Z S; Huang Y; de Silva H; Sanan D; Mahley R W; Innerarity T L; Taylor J M
Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.
The Journal of clinical investigation 1998;101(10):2151-64.
1998: Ji Z S; Pitas R E; Mahley R W
Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4.
The Journal of biological chemistry 1998;273(22):13452-60.
1998: Dichek H L; Brecht W; Fan J; Ji Z S; McCormick S P; Akeefe H; Conzo L; Sanan D A; Weisgraber K H; Young S G; Taylor J M; Mahley R W
Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake.
The Journal of biological chemistry 1998;273(4):1896-903.
1997: Ji Z S; Dichek H L; Miranda R D; Mahley R W
Heparan sulfate proteoglycans participate in hepatic lipaseand apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins.
The Journal of biological chemistry 1997;272(50):31285-92.
1997: Huang Y; Rall S C; Mahley R W
Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2817-24.
1997: Huang Y; Schwendner S W; Rall S C; Sanan D A; Mahley R W
Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis.
The Journal of biological chemistry 1997;272(36):22685-94.
1997: Hussain M M; Goldberg I J; Weisgraber K H; Mahley R W; Innerarity T L
Uptake of chylomicrons by the liver, but not by the bone marrow, is modulated by lipoprotein lipase activity.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(7):1407-13.
1997: McGeer P L; Walker D G; Pitas R E; Mahley R W; McGeer E G
Apolipoprotein E4 (ApoE4) but not ApoE3 or ApoE2 potentiates beta-amyloid protein activation of complement in vitro.
Brain research 1997;749(1):135-8.
1996: Weisgraber K H; Mahley R W
Human apolipoprotein E: the Alzheimer's disease connection.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(13):1485-94.
1996: Huang Y; Schwendner S W; Rall S C; Mahley R W
Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.
The Journal of biological chemistry 1996;271(46):29146-51.
1996: Mahley R W
Heparan sulfate proteoglycan/low density lipoprotein receptor-related protein pathway involved in type III hyperlipoproteinemia and Alzheimer's disease.
Israel journal of medical sciences 1996;32(6):414-29.
1996: Mahley R W; Nathan B P; Pitas R E
Apolipoprotein E. Structure, function, and possible roles in Alzheimer's disease.
Annals of the New York Academy of Sciences 1996;777():139-45.
1995: Bellosta S; Mahley R W; Sanan D A; Murata J; Newland D L; Taylor J M; Pitas R E
Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.
The Journal of clinical investigation 1995;96(5):2170-9.
1995: Bellosta S; Nathan B P; Orth M; Dong L M; Mahley R W; Pitas R E
Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth.
The Journal of biological chemistry 1995;270(45):27063-71.
1995: Holtzman D M; Pitas R E; Kilbridge J; Nathan B; Mahley R W; Bu G; Schwartz A L
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9480-4.
1995: Nathan B P; Chang K C; Bellosta S; Brisch E; Ge N; Mahley R W; Pitas R E
The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization.
The Journal of biological chemistry 1995;270(34):19791-9.
1995: Mahley R W; Nathan B P; Bellosta S; Pitas R E
Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease.
Current opinion in lipidology 1995;6(2):86-91.
1995: Hussain M M; Innerarity T L; Brecht W J; Mahley R W
Chylomicron metabolism in normal, cholesterol-fed, and Watanabe heritable hyperlipidemic rabbits. Saturation of the sequestration step of the remnant clearance pathway.
The Journal of biological chemistry 1995;270(15):8578-87.
1995: Mahley R W; Palaoglu K E; Atak Z; Dawson-Pepin J; Langlois A M; Cheung V; Onat H; Fulks P; Mahley L L; Vakar F
Turkish Heart Study: lipids, lipoproteins, and apolipoproteins.
Journal of lipid research 1995;36(4):839-59.
1995: Ji Z S; Sanan D A; Mahley R W
Intravenous heparinase inhibits remnant lipoprotein clearance from the plasma and uptake by the liver: in vivo role of heparan sulfate proteoglycans.
Journal of lipid research 1995;36(3):583-92.
1994: Ji Z S; Mahley R W
Lactoferrin binding to heparan sulfate proteoglycans and the LDL receptor-related protein. Further evidence supporting the importance of direct binding of remnant lipoproteins to HSPG.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(12):2025-31.
1994: Fazio S; Sanan D A; Lee Y L; Ji Z S; Mahley R W; Rall S C
Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142).
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(11):1873-9.
1994: Dong L M; Wilson C; Wardell M R; Simmons T; Mahley R W; Weisgraber K H; Agard D A
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.
The Journal of biological chemistry 1994;269(35):22358-65.
1994: Mahley R W; Ji Z S; Brecht W J; Miranda R D; He D
Role of heparan sulfate proteoglycans and the LDL receptor-related protein in remnant lipoprotein metabolism.
Annals of the New York Academy of Sciences 1994;737():39-52.
1994: Fan J; Wang J; Bensadoun A; Lauer S J; Dang Q; Mahley R W; Taylor J M
Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8724-8.
1994: Sanan D A; Weisgraber K H; Russell S J; Mahley R W; Huang D; Saunders A; Schmechel D; Wisniewski T; Frangione B; Roses A D
Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.
The Journal of clinical investigation 1994;94(2):860-9.
1994: Wilson C; Mau T; Weisgraber K H; Wardell M R; Mahley R W; Agard D A
Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.
Structure (London, England : 1993) 1994;2(8):713-8.
1994: de Silva H V; Más-Oliva J; Taylor J M; Mahley R W
Identification of apolipoprotein B-100 low density lipoproteins, apolipoprotein B-48 remnants, and apolipoprotein E-rich high density lipoproteins in the mouse.
Journal of lipid research 1994;35(7):1297-310.
1994: Ji Z S; Lauer S J; Fazio S; Bensadoun A; Taylor J M; Mahley R W
Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture.
The Journal of biological chemistry 1994;269(18):13429-36.
1994: Ji Z S; Fazio S; Mahley R W
Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia.
The Journal of biological chemistry 1994;269(18):13421-8.
1994: Nathan B P; Bellosta S; Sanan D A; Weisgraber K H; Mahley R W; Pitas R E
Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro.
Science (New York, N.Y.) 1994;264(5160):850-2.
1994: Ji Z S; Fazio S; Lee Y L; Mahley R W
Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans.
The Journal of biological chemistry 1994;269(4):2764-72.
1994: de Silva H V; Lauer S J; Wang J; Simonet W S; Weisgraber K H; Mahley R W; Taylor J M
Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E.
The Journal of biological chemistry 1994;269(3):2324-35.
1993: Chiesa G; Johnson D F; Yao Z; Innerarity T L; Mahley R W; Young S G; Hammer R H; Hobbs H H
Expression of human apolipoprotein B100 in transgenic mice. Editing of human apolipoprotein B100 mRNA.
The Journal of biological chemistry 1993;268(32):23747-50.
1993: Bersot T P; Russell S J; Thatcher S R; Pomernacki N K; Mahley R W; Weisgraber K H; Innerarity T L; Fox C S
A unique haplotype of the apolipoprotein B-100 allele associated with familial defective apolipoprotein B-100 in a Chinese man discovered during a study of the prevalence of this disorder.
Journal of lipid research 1993;34(7):1149-54.
1993: de Silva H V; Lauer S J; Mahley R W; Weisgraber K H; Taylor J M
Apolipoproteins E and C-III have opposing roles in the clearance of lipoprotein remnants in transgenic mice.
Biochemical Society transactions 1993;21(2):483-7.
1993: Ji Z S; Brecht W J; Miranda R D; Hussain M M; Innerarity T L; Mahley R W
Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells.
The Journal of biological chemistry 1993;268(14):10160-7.
1992: Handelmann G E; Boyles J K; Weisgraber K H; Mahley R W; Pitas R E
Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro.
Journal of lipid research 1992;33(11):1677-88.
1992: Rall S C; Mahley R W
The role of apolipoprotein E genetic variants in lipoprotein disorders.
Journal of internal medicine 1992;231(6):653-9.
1991: Hussain M M; Maxfield F R; Más-Oliva J; Tabas I; Ji Z S; Innerarity T L; Mahley R W
Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.
The Journal of biological chemistry 1991;266(21):13936-40.
1991: Wilson C; Wardell M R; Weisgraber K H; Mahley R W; Agard D A
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.
Science (New York, N.Y.) 1991;252(5014):1817-22.
1991: Mahley R W; Weisgraber K H; Innerarity T L; Rall S C
Genetic defects in lipoprotein metabolism. Elevation of atherogenic lipoproteins caused by impaired catabolism.
JAMA : the journal of the American Medical Association 1991;265(1):78-83.
1990: Weisgraber K H; Mahley R W; Kowal R C; Herz J; Goldstein J L; Brown M S
Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1990;265(36):22453-9.
1990: Innerarity T L; Mahley R W; Weisgraber K H; Bersot T P; Krauss R M; Vega G L; Grundy S M; Friedl W; Davignon J; McCarthy B J
Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
Journal of lipid research 1990;31(8):1337-49.
1990: Crook D; Weisgraber K H; Boyles J K; Mahley R W
Isolation and characterization of plasma lipoproteins of common marmoset monkey. Comparison of effects of control and atherogenic diets.
Arteriosclerosis (Dallas, Tex.) 1990;10(4):633-47.
1990: Crook D; Weisgraber K H; Rall S C; Mahley R W
Isolation and characterization of several plasma apolipoproteins of common marmoset monkey.
Arteriosclerosis (Dallas, Tex.) 1990;10(4):625-32.
1990: Kowal R C; Herz J; Weisgraber K H; Mahley R W; Brown M S; Goldstein J L
Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1990;265(18):10771-9.
1990: Weisgraber K H; Innerarity T L; Rall S C; Mahley R W
Atherogenic lipoproteins resulting from genetic defects of apolipoproteins B and E.
Annals of the New York Academy of Sciences 1990;598():37-48.
1989: Hussain M M; Mahley R W; Boyles J K; Lindquist P A; Brecht W J; Innerarity T L
Chylomicron metabolism. Chylomicron uptake by bone marrow in different animal species.
The Journal of biological chemistry 1989;264(30):17931-8.
1989: Mahley R W; Weisgraber K H; Hussain M M; Greenman B; Fisher M; Vogel T; Gorecki M
Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits.
The Journal of clinical investigation 1989;83(6):2125-30.
1989: Hussain M M; Mahley R W; Boyles J K; Fainaru M; Brecht W J; Lindquist P A
Chylomicron-chylomicron remnant clearance by liver and bone marrow in rabbits. Factors that modify tissue-specific uptake.
The Journal of biological chemistry 1989;264(16):9571-82.
1989: Lalazar A; Mahley R W
Human apolipoprotein E. Receptor binding activity of truncated variants with carboxyl-terminal deletions.
The Journal of biological chemistry 1989;264(15):8447-50.
1989: Rall S C; Newhouse Y M; Clarke H R; Weisgraber K H; McCarthy B J; Mahley R W; Bersot T P
Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant.
The Journal of clinical investigation 1989;83(4):1095-101.
1989: Boyles J K; Zoellner C D; Anderson L J; Kosik L M; Pitas R E; Weisgraber K H; Hui D Y; Mahley R W; Gebicke-Haerter P J; Ignatius M J
A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.
The Journal of clinical investigation 1989;83(3):1015-31.
1989: Weisgraber K H; Newhouse Y M; Taylor J M; Tuan B; Nestruck A C; Davignon J; Mahley R W
Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes.
Arteriosclerosis (Dallas, Tex.) 1989;9(1):50-7.
1989: Mahley R W; Hui D Y; Innerarity T L; Beisiegel U
Chylomicron remnant metabolism. Role of hepatic lipoprotein receptors in mediating uptake.
Arteriosclerosis (Dallas, Tex.) 1989;9(1 Suppl):I14-8.
1988: Weisgraber K H; Newhouse Y M; Mahley R W
Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide probes.
Biochemical and biophysical research communications 1988;157(3):1212-7.
1988: Weisgraber K H; Innerarity T L; Newhouse Y M; Young S G; Arnold K S; Krauss R M; Vega G L; Grundy S M; Mahley R W
Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9758-62.
1988: Koo C; Wernette-Hammond M E; Garcia Z; Malloy M J; Uauy R; East C; Bilheimer D W; Mahley R W; Innerarity T L
Uptake of cholesterol-rich remnant lipoproteins by human monocyte-derived macrophages is mediated by low density lipoprotein receptors.
The Journal of clinical investigation 1988;81(5):1332-40.
1988: Beisiegel U; Weber W; Havinga J R; Ihrke G; Hui D Y; Wernette-Hammond M E; Turck C W; Innerarity T L; Mahley R W
Apolipoprotein E-binding proteins isolated from dog and human liver.
Arteriosclerosis (Dallas, Tex.) 1988;8(3):288-97.
1988: Mahley R W
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
Science (New York, N.Y.) 1988;240(4852):622-30.
1988: Fainaru M; Funke H; Boyles J K; Ludwig E H; Innerarity T L; Mahley R W
Metabolism of canine beta-very low density lipoproteins in normal and cholesterol-fed dogs.
Arteriosclerosis (Dallas, Tex.) 1988;8(2):130-9.
1988: Lalazar A; Weisgraber K H; Rall S C; Giladi H; Innerarity T L; Levanon A Z; Boyles J K; Amit B; Gorecki M; Mahley R W
Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions.
The Journal of biological chemistry 1988;263(8):3542-5.
1987: Innerarity T L; Young S G; Poksay K S; Mahley R W; Smith R S; Milne R W; Marcel Y L; Weisgraber K H
Structural relationship of human apolipoprotein B48 to apolipoprotein B100.
The Journal of clinical investigation 1987;80(6):1794-8.
1987: Friedman G; Wernette-Hammond M E; Hui D Y; Mahley R W; Innerarity T L
Characterization of lipoprotein receptors on rat Fu5AH hepatoma cells.
Journal of lipid research 1987;28(12):1482-94.
1987: Corsini A; Spilman C H; Innerarity T L; Arnold K S; Rall S C; Boyles J K; Mahley R W
Receptor binding activity of lipid recombinants of apolipoprotein B-100 thrombolytic fragments.
Journal of lipid research 1987;28(12):1410-23.
1987: Innerarity T L; Weisgraber K H; Arnold K S; Mahley R W; Krauss R M; Vega G L; Grundy S M
Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(19):6919-23.
1987: Ludwig E H; Blackhart B D; Pierotti V R; Caiati L; Fortier C; Knott T; Scott J; Mahley R W; Levy-Wilson B; McCarthy B J
DNA sequence of the human apolipoprotein B gene.
DNA (Mary Ann Liebert, Inc.) 1987;6(4):363-72.
1987: Ignatius M J; Shooter E M; Pitas R E; Mahley R W
Lipoprotein uptake by neuronal growth cones in vitro.
Science (New York, N.Y.) 1987;236(4804):959-62.
1987: Scott J; Pease R J; Powell L M; Wallis S C; McCarthy B J; Mahley R W; Levy-Wilson B; Knott T J
Human apolipoprotein B: complete cDNA sequence and identification of structural domains of the protein.
Biochemical Society transactions 1987;15(2):195-9.
1987: Scott J; Pease R J; Powell L M; Wallis S C; McCarthy B J; Mahley R W; Levy-Wilson B; Knott T J
Apolipoprotein B gene: plasma cholesterol and atherosclerosis.
Biochemical Society symposium 1987;53():155-63.
1986: Knott T J; Wallis S C; Powell L M; Pease R J; Lusis A J; Blackhart B; McCarthy B J; Mahley R W; Levy-Wilson B; Scott J
Complete cDNA and derived protein sequence of human apolipoprotein B-100.
Nucleic acids research 1986;14(18):7501-3.
1986: Hui D Y; Brecht W J; Hall E A; Friedman G; Innerarity T L; Mahley R W
Isolation and characterization of the apolipoprotein E receptor from canine and human liver.
The Journal of biological chemistry 1986;261(9):4256-67.
1986: Bersot T P; Innerarity T L; Pitas R E; Rall S C; Weisgraber K H; Mahley R W
Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein [a] and that cause lipid accumulation in macrophages.
The Journal of clinical investigation 1986;77(2):622-30.
1986: Ignatius M J; Gebicke-Härter P J; Skene J H; Schilling J W; Weisgraber K H; Mahley R W; Shooter E M
Expression of apolipoprotein E during nerve degeneration and regeneration.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):1125-9.
1986: Mahley R W; Innerarity T L; Weisgraber K H; Rall S C; Hui D Y; Lalazar A; Boyles J K; Taylor J M; Levy-Wilson B
Cellular and molecular biology of lipoprotein metabolism: characterization of lipoprotein receptor-ligand interactions.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():821-8.
1986: Innerarity T L; Hui D Y; Bersot T P; Mahley R W
Type III hyperlipoproteinemia: a focus on lipoprotein receptor-apolipoprotein E2 interactions.
Advances in experimental medicine and biology 1986;201():273-88.
1985: Weisgraber K H; Newhouse Y M; Seymour J L; Rall S C; Mahley R W
Preparative immobiline isoelectric focusing of plasma apolipoproteins on vertical slab gels.
Analytical biochemistry 1985;151(2):455-61.
1984: Innerarity T L; Weisgraber K H; Arnold K S; Rall S C; Mahley R W
Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation.
The Journal of biological chemistry 1984;259(11):7261-7.
1984: Innerarity T L; Bersot T P; Arnold K S; Weisgraber K H; Davis P A; Forte T M; Mahley R W
Receptor binding activity of high-density lipoproteins containing apoprotein E from abetalipoproteinemic and normal neonate plasma.
Metabolism: clinical and experimental 1984;33(2):186-95.
1983: Rall S C; Weisgraber K H; Innerarity T L; Bersot T P; Mahley R W; Blum C B
Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype.
The Journal of clinical investigation 1983;72(4):1288-97.
1983: Bersot T P; Innerarity T L; Mahley R W; Havel R J
Cholesteryl ester accumulation in mouse peritoneal macrophages induced by beta-migrating very low density lipoproteins from patients with atypical dysbetalipoproteinemia.
The Journal of clinical investigation 1983;72(3):1024-33.
1983: Weisgraber K H; Rall S C; Bersot T P; Mahley R W; Franceschini G; Sirtori C R
Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I.
The Journal of biological chemistry 1983;258(4):2508-13.

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