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Ravinder Maini

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Eugene Eyo Akujuru; Ravinder N Maini
Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?
Ravinder N Maini
Anti-TNF therapy from the bench to the clinic: a paradigm of translational research.
Josef S Smolen; C Han; D M F M van der Heijde; P Emery; Joan M Bathon; Edward Keystone; Ravinder N Maini; Joachim R Kalden; Daniel Aletaha; D Baker; J Han; M Bala; E William St Clair
Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: the impacts of remission and tumour necrosis factor blockade.

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All Publications

2010: Eugene Eyo Akujuru; Ravinder N Maini
Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?
Journal of immunology (Baltimore, Md. : 1950) 2010;185(2):791-4.
2010: Ravinder N Maini
Anti-TNF therapy from the bench to the clinic: a paradigm of translational research.
Clinical medicine (London, England) 2010;10(2):161-2.
2009: Josef S Smolen; C Han; D M F M van der Heijde; P Emery; Joan M Bathon; Edward Keystone; Ravinder N Maini; Joachim R Kalden; Daniel Aletaha; D Baker; J Han; M Bala; E William St Clair
Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: the impacts of remission and tumour necrosis factor blockade.
Annals of the rheumatic diseases 2009;68(6):823-7.
2008: Michael J Elliot; Ravinder N Maini; Eugene Eyo Akujuru; Alice Long-Fox; Peter Charles; Peter Katasikis; Fionula M Brennan; Hanny Bijl; John Ghrayeb; James N Woody
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
Arthritis and rheumatism 2008;58(2 Suppl):S92-S101.
2008: Iain Hrynaszkiewicz; Peter E Lipsky; Ravinder N Maini
Introducing Arthritis Research & Therapy's 10th anniversary issue, 'The Scientific Basis of Rheumatology: A Decade of Progress'.
Arthritis research & therapy 2008;10(5):119.
2007: Ravinder N Maini; Marc Feldmann
The pitfalls in the development of biologic therapy.
Nature clinical practice. Rheumatology 2007;3(1):1.
2006: Ravinder N Maini; PC Taylor; J Szechinski; K Pavelka; J Bröll; G Balint; P Emery; F Raemen; J Petersen; J Smolen; D Thomson; T Kishimoto
Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate.
Arthritis and rheumatism 2006;54(9):2817-29.
2006: Josef S Smolen; Chenglong Han; Désirée van der Heijde; Paul Emery; Joan M Bathon; Edward Keystone; Joachim R Kalden; Michael Schiff; Mohan Bala; Daniel Baker; John Han; Ravinder N Maini; E William St Clair
Infliximab treatment maintains employability in patients with early rheumatoid arthritis.
Arthritis and rheumatism 2006;54(3):716-22.
2006: Josef S Smolen; Désirée van der Heijde; E William St Clair; Paul Emery; Joan M Bathon; Edward Keystone; Ravinder N Maini; Joachim R Kalden; Michael Schiff; Daniel Baker; Chenglong Han; John Han; Mohan Bala
Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trial.
Arthritis and rheumatism 2006;54(3):702-10.
2006: Josef S Smolen; Ravinder N Maini
Interleukin-6: a new therapeutic target.
Arthritis research & therapy 2006;8 Suppl 2():S5.
2006: PC Taylor; A Steuer; Johann Gruber; Catherine McClinton; David O Cosgrove; Martin J K Blomley; PA Marsters; C L Wagner; Ravinder N Maini
Ultrasonographic and radiographic results from a two-year controlled trial of immediate or one-year-delayed addition of infliximab to ongoing methotrexate therapy in patients with erosive early rheumatoid arthritis.
Arthritis and rheumatism 2006;54(1):47-53.
2005: Ravinder N Maini
The 2005 International Symposium on Advances in Targeted Therapies: what have we learned in the 2000s and where are we going?
Annals of the rheumatic diseases 2005;64 Suppl 4():iv106-8.
2005: Josef S Smolen; Chenglong Han; Mohan Bala; Ravinder N Maini; Joachim R Kalden; Désirée van der Heijde; Ferdinand C Breedveld; D E Furst; P E Lipsky
Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study.
Arthritis and rheumatism 2005;52(4):1020-30.
2004: E William St Clair; Désirée van der Heijde; Josef S Smolen; Ravinder N Maini; Joan M Bathon; Paul Emery; Edward Keystone; Michael Schiff; Joachim R Kalden; Ben Wang; Kimberly Dewoody; Roberta Weiss; Daniel Baker
Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial.
Arthritis and rheumatism 2004;50(11):3432-43.
2004: PC Taylor; A Steuer; Johann Gruber; David O Cosgrove; Martin J K Blomley; PA Marsters; C L Wagner; Catherine McClinton; Ravinder N Maini
Comparison of ultrasonographic assessment of synovitis and joint vascularity with radiographic evaluation in a randomized, placebo-controlled study of infliximab therapy in early rheumatoid arthritis.
Arthritis and rheumatism 2004;50(4):1107-16.
2004: Ravinder N Maini; F C Breedveld; Joachim R Kalden; J S Smolen; D Furst; M H Weisman; E William St Clair; Gregory F Keenan; Désirée van der Heijde; PA Marsters; P E Lipsky
Sustained improvement over two years in physical function, structural damage, and signs and symptoms among patients with rheumatoid arthritis treated with infliximab and methotrexate.
Arthritis and rheumatism 2004;50(4):1051-65.
2004: Eugene Eyo Akujuru; Fionula M Brennan; Richard O Williams; Jim Woody; Ravinder N Maini
The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.
Best practice & research. Clinical rheumatology 2004;18(1):59-80.
2004: Ravinder N Maini
Current and new antitumor necrosis factor agents in perspective.
Arthritis research & therapy 2004;6 Suppl 2():S1-2.
2004: Eugene Eyo Akujuru; Fionula M Brennan; Ewa Paleolog; Andrew P Cope; Peter Taylor; Richard Williams; Jim Woody; Ravinder N Maini
Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?
Novartis Foundation symposium 2004;256():53-69; discussion 69-73, 106-11, 266-9.
2003: Marvin Fritzler; Allan Wiik; Eng M Tan; Josef S Smolen; J Steven McDougal; Edward Chan; Thomas P Gordon; John Hardin; Joachim R Kalden; Robert G Lahita; Ravinder N Maini; Westley H Reeves; Naomi F Rothfield; Yoshinari Takasaki; Merlin Wilson; Martha G Byrd; Lloyd Slivka; James A Koziol
A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. III. Comparative performance characteristics of academic and manufacturers' laboratories.
The Journal of rheumatology 2003;30(11):2374-81.
2003: Eugene Eyo Akujuru; Ravinder N Maini
Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases.
Nature medicine 2003;9(10):1245-50.
2002: Peter E Lipsky; David T Felson; Ravinder N Maini
Blocking tumor necrosis factor inhibits radiographic damage even in patients who show minimal or no clinical improvement: comment on the concise communication by Boers.
Arthritis and rheumatism 2002;46(10):2817-8; author reply 2718-21.
2002: Evangelos Andreakos; Brian M J Foxwell; Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
Cytokines and anti-cytokine biologicals in autoimmunity: present and future.
Cytokine & growth factor reviews 2002;13(4-5):299-313.
2002: J Vencovský; E Zd'árský; SP Moyes; Al Hajeer; S Ruzicková; Z Cimburek; WE Ollier; Ravinder N Maini; RA Mageed
Polymorphism in the immunoglobulin VH gene V1-69 affects susceptibility to rheumatoid arthritis in subjects lacking the HLA-DRB1 shared epitope.
Rheumatology (Oxford, England) 2002;41(4):401-10.
2002: L Marinova-Mutafchieva; Richard O Williams; K Funa; Ravinder N Maini; Nathan J Zvaifler
Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal cells in experimental arthritis.
Arthritis and rheumatism 2002;46(2):507-13.
2002: Ravinder N Maini; Eugene Eyo Akujuru
How does infliximab work in rheumatoid arthritis?
Arthritis research 2002;4 Suppl 2():S22-8.
2002: Eugene Eyo Akujuru; Ravinder N Maini
Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies.
Joint, bone, spine : revue du rhumatisme 2002;69(1):12-8.
2002: Eng M Tan; Josef S Smolen; J Steven McDougal; Marvin Fritzler; Thomas Gordon; John Hardin; Joachim R Kalden; Robert G Lahita; Ravinder N Maini; Westley H Reeves; Naomi F Rothfield; Yoshinari Takasaki; Allan Wiik; Merlin Wilson; James A Koziol
A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. II. Potential for quantitation of antibody content.
The Journal of rheumatology 2002;29(1):68-74.
2001: SC Ballara; PC Taylor; Petra Reusch; Dieter Marmé; Eugene Eyo Akujuru; Ravinder N Maini; Ewa Paleolog
Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis.
Arthritis and rheumatism 2001;44(9):2055-64.
2001: Anne-Marie Malfait; Richard O Williams; AS Malik; Ravinder N Maini; Eugene Eyo Akujuru
Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.
Arthritis and rheumatism 2001;44(5):1215-24.
2001: J Bondeson; Ravinder N Maini
Tumour necrosis factor as a therapeutic target in rheumatoid arthritis and other chronic inflammatory diseases: the clinical experience with infliximab (REMICADE).
International journal of clinical practice 2001;55(3):211-6.
2001: Eugene Eyo Akujuru; Ravinder N Maini; J Bondeson; P Taylor; Brian M J Foxwell; Fionula M Brennan
Cytokine blockade in rheumatoid arthritis.
Advances in experimental medicine and biology 2001;490():119-27.
2001: Eugene Eyo Akujuru; Ravinder N Maini
Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
Annual review of immunology 2001;19():163-96.
2000: Richard O Williams; L Marinova-Mutafchieva; Eugene Eyo Akujuru; Ravinder N Maini
Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7240-5.
2000: P J Charles; RJ Smeenk; J De Jong; Eugene Eyo Akujuru; Ravinder N Maini
Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: findings in open-label and randomized placebo-controlled trials.
Arthritis and rheumatism 2000;43(11):2383-90.
2000: Eugene Eyo Akujuru; JM Miotla; Ewa Paleolog; R Williams; Anne-Marie Malfait; P Taylor; Fionula M Brennan; Ravinder N Maini
Future prospects for anti-cytokine treatment.
Annals of the rheumatic diseases 2000;59 Suppl 1():i119-22.
2000: R O Williams; Eugene Eyo Akujuru; Ravinder N Maini
Cartilage destruction and bone erosion in arthritis: the role of tumour necrosis factor alpha.
Annals of the rheumatic diseases 2000;59 Suppl 1():i75-80.
2000: L Marinova-Mutafchieva; P Taylor; K Funa; Ravinder N Maini; Nathan J Zvaifler
Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint.
Arthritis and rheumatism 2000;43(9):2046-55.
2000: L Marinova-Mutafchieva; Richard O Williams; C Mauri; LJ Mason; MJ Walmsley; P C Taylor; Eugene Eyo Akujuru; Ravinder N Maini
A comparative study into the mechanisms of action of anti-tumor necrosis factor alpha, anti-CD4, and combined anti-tumor necrosis factor alpha/anti-CD4 treatment in early collagen-induced arthritis.
Arthritis and rheumatism 2000;43(3):638-44.
2000: Nathan J Zvaifler; L Marinova-Mutafchieva; G Adams; C J Edwards; J Moss; Jan A Burger; Ravinder N Maini
Mesenchymal precursor cells in the blood of normal individuals.
Arthritis research 2000;2(6):477-88.
2000: P C Taylor; A M Peters; Ewa Paleolog; P T Chapman; M J Elliott; R McCloskey; Eugene Eyo Akujuru; Ravinder N Maini
Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis.
Arthritis and rheumatism 2000;43(1):38-47.
1999: Eugene Eyo Akujuru; Ravinder N Maini
The role of cytokines in the pathogenesis of rheumatoid arthritis.
Rheumatology (Oxford, England) 1999;38 Suppl 2():3-7.
1999: Richard O Williams; Anne-Marie Malfait; DM Butler; MJ Walmsley; Eugene Eyo Akujuru; Ravinder N Maini
Combination therapy with DMARDs and biological agents in collagen-induced arthritis.
Clinical and experimental rheumatology 1999;17(6 Suppl 18):S115-20.
1999: Ravinder N Maini; P C Taylor; Ewa Paleolog; P Charles; SC Ballara; Fionula M Brennan; Eugene Eyo Akujuru
Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis.
Annals of the rheumatic diseases 1999;58 Suppl 1():I56-60.
1999: Eugene Eyo Akujuru; J Bondeson; Fionula M Brennan; Brian M J Foxwell; Ravinder N Maini
The rationale for the current boom in anti-TNFalpha treatment. Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha and minimise hazards?
Annals of the rheumatic diseases 1999;58 Suppl 1():I27-31.
1999: P Charles; M J Elliott; D Davis; A Potter; J R Kalden; C Antoni; F C Breedveld; J S Smolen; G Eberl; K deWoody; Eugene Eyo Akujuru; Ravinder N Maini
Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1521-8.
1999: Anne-Marie Malfait; AS Malik; L Marinova-Mutafchieva; DM Butler; Ravinder N Maini; Eugene Eyo Akujuru
The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):6278-83.
1999: SC Ballara; QAISAR SIRAJ; Ravinder N Maini; Patrick J W Venables
Sustained response to doxycycline therapy in two patients with SAPHO syndrome.
Arthritis and rheumatism 1999;42(4):819-21.
1999: Eng M Tan; Josef S Smolen; J S McDougal; BT Butcher; D Conn; R Dawkins; Marvin Fritzler; T Gordon; John Hardin; Joachim R Kalden; Robert G Lahita; Ravinder N Maini; Naomi F Rothfield; RJ Smeenk; Y Takasaki; Walther J van Venrooij; Allan Wiik; M Wilson; J A Koziol
A critical evaluation of enzyme immunoassays for detection of antinuclear autoantibodies of defined specificities. I. Precision, sensitivity, and specificity.
Arthritis and rheumatism 1999;42(3):455-64.
1998: Richard O Williams; C Mauri; LJ Mason; L Marinova-Mutafchieva; S E Ross; Eugene Eyo Akujuru; Ravinder N Maini
Therapeutic actions of cyclosporine and anti-tumor necrosis factor alpha in collagen-induced arthritis and the effect of combination therapy.
Arthritis and rheumatism 1998;41(10):1806-12.
1998: Ravinder N Maini; F C Breedveld; Joachim R Kalden; J S Smolen; D Davis; J D Macfarlane; Christian Antoni; Burkhard F Leeb; MJ Elliott; Jim Woody; Thomas F Schaible; Eugene Eyo Akujuru
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis.
Arthritis and rheumatism 1998;41(9):1552-63.
1998: SP Moyes; Ravinder N Maini; RA Mageed
Differential use of immunoglobulin light chain genes and B lymphocyte expansion at sites of disease in rheumatoid arthritis (RA) compared with circulating B lymphocytes.
Clinical and experimental immunology 1998;113(2):276-88.
1998: Ewa Paleolog; S Young; A C Stark; R V McCloskey; Eugene Eyo Akujuru; Ravinder N Maini
Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis.
Arthritis and rheumatism 1998;41(7):1258-65.
1998: Anne-Marie Malfait; DM Butler; D H Presky; Ravinder N Maini; Fionula M Brennan; Eugene Eyo Akujuru
Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis.
Clinical and experimental immunology 1998;111(2):377-83.
1998: Eugene Eyo Akujuru; P Charles; P Taylor; Ravinder N Maini
Biological insights from clinical trials with anti-TNF therapy.
Springer seminars in immunopathology 1998;20(1-2):211-28.
1998: F M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
Role of pro-inflammatory cytokines in rheumatoid arthritis.
Springer seminars in immunopathology 1998;20(1-2):133-47.
1998: Eugene Eyo Akujuru; Ravinder N Maini
Rheumatoid arthritis: introduction.
Springer seminars in immunopathology 1998;20(1-2):3-4.
1997: S E Ross; Richard O Williams; LJ Mason; C Mauri; L Marinova-Mutafchieva; Anne-Marie Malfait; Ravinder N Maini; Eugene Eyo Akujuru
Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6253-9.
1997: A C Horsfall; DM Butler; L Marinova; P J Warden; Richard O Williams; Ravinder N Maini; Eugene Eyo Akujuru
Suppression of collagen-induced arthritis by continuous administration of IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5687-96.
1997: DM Butler; Anne-Marie Malfait; LJ Mason; P J Warden; george kollias; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2867-76.
1997: D Davis; P J Charles; A Potter; Eugene Eyo Akujuru; Ravinder N Maini; M J Elliott
Anaemia of chronic disease in rheumatoid arthritis: in vivo effects of tumour necrosis factor alpha blockade.
British journal of rheumatology 1997;36(9):950-6.
1997: Eng M Tan; T E Feltkamp; Josef S Smolen; BT Butcher; R Dawkins; Marvin Fritzler; T Gordon; John Hardin; Joachim R Kalden; Robert G Lahita; Ravinder N Maini; J S McDougal; Naomi F Rothfield; RJ Smeenk; Y Takasaki; Allan Wiik; M R Wilson; J A Koziol
Range of antinuclear antibodies in "healthy" individuals.
Arthritis and rheumatism 1997;40(9):1601-11.
1997: Fionula M Brennan; K A Browne; P A Green; J M Jaspar; Ravinder N Maini; Eugene Eyo Akujuru
Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy.
British journal of rheumatology 1997;36(6):643-50.
1997: MJ Elliott; P Woo; P Charles; A Long-Fox; Jim Woody; Ravinder N Maini
Suppression of fever and the acute-phase response in a patient with juvenile chronic arthritis treated with monoclonal antibody to tumour necrosis factor-alpha (cA2).
British journal of rheumatology 1997;36(5):589-93.
1997: J Vencovský; Ravinder N Maini; WE Ollier; RA Mageed
Immunoglobulin variable region (IgV) gene expression in rheumatoid factors from monozygotic twins with rheumatoid arthritis.
Annals of the New York Academy of Sciences 1997;815():324-6.
1997: RA Mageed; SP Moyes; J Vencovský; Ravinder N Maini
Somatic mutation and CDR3 length of immunoglobulin lambda variable region genes in the synovium of patients with rheumatoid arthritis.
Annals of the New York Academy of Sciences 1997;815():319-23.
1997: Ravinder N Maini; M Elliott; Fionula M Brennan; Richard O Williams; Eugene Eyo Akujuru
TNF blockade in rheumatoid arthritis: implications for therapy and pathogenesis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1997;105(4):257-63.
1997: Josef S Smolen; BT Butcher; Marvin Fritzler; T Gordon; John Hardin; Joachim R Kalden; Robert G Lahita; Ravinder N Maini; Westley Reeves; M Reichlin; Naomi F Rothfield; Y Takasaki; Walther J van Venrooij; Eng M Tan
Reference sera for antinuclear antibodies. II. Further definition of antibody specificities in international antinuclear antibody reference sera by immunofluorescence and western blotting.
Arthritis and rheumatism 1997;40(3):413-8.
1997: L Marinova-Mutafchieva; Richard O Williams; LJ Mason; C Mauri; Eugene Eyo Akujuru; Ravinder N Maini
Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA).
Clinical and experimental immunology 1997;107(3):507-12.
1997: Eugene Eyo Akujuru; MJ Elliott; Jim Woody; Ravinder N Maini
Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis.
Advances in immunology 1997;64():283-350.
1996: A C Horsfall; J M Li; Ravinder N Maini
Placental and fetal cardiac laminin are targets for cross-reacting autoantibodies from mothers of children with congenital heart block.
Journal of autoimmunity 1996;9(4):561-8.
1996: Ravinder N Maini
The role of cytokines in rheumatoid arthritis. The Croonian Lecture 1995.
Journal of the Royal College of Physicians of London 1996;30(4):344-51.
1996: SP Moyes; C M Brown; B B Scott; Ravinder N Maini; RA Mageed
Analysis of V kappa genes in rheumatoid arthritis (RA) synovial B lymphocytes provides evidence for both polyclonal activation and antigen-driven selection.
Clinical and experimental immunology 1996;105(1):89-98.
1996: Ewa Paleolog; M Hunt; M J Elliott; Eugene Eyo Akujuru; Ravinder N Maini; J N Woody
Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis.
Arthritis and rheumatism 1996;39(7):1082-91.
1996: L M Williams; D L Gibbons; A Gearing; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.
The Journal of clinical investigation 1996;97(12):2833-41.
1996: P C Taylor; Cong-Qiu Chu; C Plater-Zyberk; Ravinder N Maini
Transfer of type II collagen-induced arthritis from DBA/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1.
Immunology 1996;88(2):315-21.
1996: MJ Walmsley; P D Katsikis; E Abney; S Parry; Richard O Williams; Ravinder N Maini; Eugene Eyo Akujuru
Interleukin-10 inhibition of the progression of established collagen-induced arthritis.
Arthritis and rheumatism 1996;39(3):495-503.
1996: SM Brookes; Shara Cohen; E J Price; L M Webb; Eugene Eyo Akujuru; Ravinder N Maini; Patrick J W Venables
T cell clones from a Sjögren's syndrome salivary gland biopsy produce high levels of IL-10.
Clinical and experimental immunology 1996;103(2):268-72.
1995: M J Elliott; Ravinder N Maini
Anti-cytokine therapy in rheumatoid arthritis.
Baillière's clinical rheumatology 1995;9(4):633-52.
1995: Eugene Eyo Akujuru; F M Brennan; M J Elliott; R O Williams; Ravinder N Maini
TNF alpha is an effective therapeutic target for rheumatoid arthritis.
Annals of the New York Academy of Sciences 1995;766():272-8.
1995: Ravinder N Maini
A perspective on anti-cytokine and anti-T cell-directed therapies in rheumatoid arthritis.
Clinical and experimental rheumatology 1995;13 Suppl 12():S35-40.
1995: R Misra; K Darton; R F Jewkes; C M Black; Ravinder N Maini
Arthritis in scleroderma.
British journal of rheumatology 1995;34(9):831-7.
1995: Ravinder N Maini; M J Elliott; Fionula M Brennan; Eugene Eyo Akujuru
Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)
Clinical and experimental immunology 1995;101(2):207-12.
1995: DM Butler; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist.
European cytokine network 1995;6(4):225-30.
1995: Fionula M Brennan; D L Gibbons; A P Cope; P Katsikis; Ravinder N Maini; Eugene Eyo Akujuru
TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.
Scandinavian journal of immunology 1995;42(1):158-65.
1995: J Vencovsky; RA Mageed; W E R Ollier; Ravinder N Maini
Monozygotic rheumatoid arthritis twin pairs express similar levels of conserved immunoglobulin V gene in polyclonal rheumatoid factors irrespective of disease status.
Scandinavian journal of immunology 1995;42(1):147-57.
1995: Shara Cohen; P D Katsikis; Cong-Qiu Chu; H Thomssen; L M Webb; Ravinder N Maini; Marco Londei; Eugene Eyo Akujuru
High level of interleukin-10 production by the activated T cell population within the rheumatoid synovial membrane.
Arthritis and rheumatism 1995;38(7):946-52.
1995: Ravinder N Maini; M J Elliott; Fionula M Brennan; R O Williams; Cong-Qiu Chu; Ewa Paleolog; P J Charles; P C Taylor; Eugene Eyo Akujuru
Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease.
Immunological reviews 1995;144():195-223.
1995: Richard O Williams; J Ghrayeb; Eugene Eyo Akujuru; Ravinder N Maini
Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4.
Immunology 1995;84(3):433-9.
1995: C M Brown; K J Fitzgerald; SP Moyes; RA Mageed; david williams; Ravinder N Maini
Sequence analysis of immunoglobulin heavy-chain variable region genes from the synovium of a rheumatoid arthritis patient shows little evidence of mutation but diverse CDR3.
Immunology 1995;84(3):367-74.
1995: SM Brookes; E J Price; Patrick J W Venables; Ravinder N Maini
Interferon-gamma and epithelial cell activation in Sjögren's syndrome.
British journal of rheumatology 1995;34(3):226-31.
1995: P C Taylor; C Plater-Zyberk; Ravinder N Maini
The role of the B cells in the adoptive transfer of collagen-induced arthritis from DBA/1 (H-2q) to SCID (H-2d) mice.
European journal of immunology 1995;25(3):763-9.
1995: M J Elliott; M Feldmann; Ravinder N Maini
TNF alpha blockade in rheumatoid arthritis: rationale, clinical outcomes and mechanisms of action.
International journal of immunopharmacology 1995;17(2):141-5.
1995: Fionula M Brennan; A P Cope; P Katsikis; D L Gibbons; Ravinder N Maini; Eugene Eyo Akujuru
Selective immunosuppression of tumour necrosis factor-alpha in rheumatoid arthritis.
Chemical immunology 1995;60():48-60.
1994: C Plater-Zyberk; P C Taylor; M G Blaylock; Ravinder N Maini
Anti-CD5 therapy decreases severity of established disease in collagen type II-induced arthritis in DBA/1 mice.
Clinical and experimental immunology 1994;98(3):442-7.
1994: Ravinder N Maini; M Elliott; Fionula M Brennan; R O Williams; Eugene Eyo Akujuru
Targeting TNF alpha for the therapy of rheumatoid arthritis.
Clinical and experimental rheumatology 1994;12 Suppl 11():S63-6.
1994: M J Elliott; Ravinder N Maini; Eugene Eyo Akujuru; A Long-Fox; P Charles; H Bijl; J N Woody
Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis.
Lancet 1994;344(8930):1125-7.
1994: M J Elliott; Ravinder N Maini; Eugene Eyo Akujuru; J R Kalden; C Antoni; J S Smolen; Burkhard F Leeb; F C Breedveld; J D Macfarlane; H Bijl
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis.
Lancet 1994;344(8930):1105-10.
1994: A P Cope; Marco Londei; N R Chu; Shara Cohen; M J Elliott; Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.
The Journal of clinical investigation 1994;94(2):749-60.
1994: B B Scott; S Sadigh; E M Andrew; Ravinder N Maini; RA Mageed
Affinity maturation and isotype switch in clonally related anti-erythrocyte autoantibodies.
Scandinavian journal of immunology 1994;40(1):16-21.
1994: P D Katsikis; Cong-Qiu Chu; Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
Immunoregulatory role of interleukin 10 in rheumatoid arthritis.
The Journal of experimental medicine 1994;179(5):1517-27.
1994: S Sadigh; B B Scott; RA Mageed; A Malcolm; E M Andrew; Ravinder N Maini
Identification of hybridomas derived from mouse CD5+ B lymphocytes by fluorescent staining for cytoplasmic CD5 expression.
Immunology 1994;81(4):558-63.
1994: R O Williams; L J Mason; Eugene Eyo Akujuru; Ravinder N Maini
Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2762-6.
1994: RA Mageed; J Vencovsky; Ravinder N Maini
Rheumatoid factors and germline genes in rheumatoid arthritis: evidence of an intrinsic B-lymphocyte defect?
British journal of rheumatology 1994;33(2):105-7.
1994: Ravinder N Maini; M J Elliott; P J Charles; Eugene Eyo Akujuru
Immunological intervention reveals reciprocal roles for tumor necrosis factor-alpha and interleukin-10 in rheumatoid arthritis and systemic lupus erythematosus.
Springer seminars in immunopathology 1994;16(2-3):327-36.
1993: M J Elliott; Ravinder N Maini; Eugene Eyo Akujuru; A Long-Fox; P Charles; P Katsikis; Fionula M Brennan; J Walker; H Bijl; J Ghrayeb
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
Arthritis and rheumatism 1993;36(12):1681-90.
1993: P J Charles; Ravinder N Maini
The clinical implications of autoantibody detection in rheumatology.
Journal of the Royal College of Physicians of London 1993;27(4):358-62.
1993: D Aderka; A Wysenbeek; Hartmut Engelmann; A P Cope; F Brennan; Y Molad; V Hornik; Y Levo; Ravinder N Maini; Eugene Eyo Akujuru
Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus.
Arthritis and rheumatism 1993;36(8):1111-20.
1993: B B Scott; S Sadigh; M Stow; RA Mageed; E M Andrew; Ravinder N Maini
Anti-mouse red blood cell monoclonal antibodies use functionally rearranged genes from the VH J558 family and are derived from the CD5- B-lymphocyte subpopulation.
Immunology 1993;79(4):568-73.
1993: C T Pease; W Shattles; N K Barrett; Ravinder N Maini
The arthropathy of Sjögren's syndrome.
British journal of rheumatology 1993;32(7):609-13.
1993: C T Pease; P J Charles; W Shattles; J Markwick; Ravinder N Maini
Serological and immunogenetic markers of extraglandular primary Sjögren's syndrome.
British journal of rheumatology 1993;32(7):574-7.
1993: B B Scott; S Sadigh; M Stow; RA Mageed; E M Andrew; Ravinder N Maini
Molecular mechanisms resulting in pathogenic anti-mouse erythrocyte antibodies in New Zealand black mice.
Clinical and experimental immunology 1993;93(1):26-33.
1993: A P Cope; D L Gibbons; D Aderka; Brian M J Foxwell; David Wallach; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.
Cytokine 1993;5(3):205-12.
1993: Ravinder N Maini; Fionula M Brennan; R Williams; Cong-Qiu Chu; A P Cope; D Gibbons; M Elliott; Eugene Eyo Akujuru
TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.
Clinical and experimental rheumatology 1993;11 Suppl 8():S173-5.
1993: P J Charles; Ravinder N Maini
Antibodies to neutrophil cytoplasmic antigens in rheumatoid arthritis.
Advances in experimental medicine and biology 1993;336():367-70.
1992: J Vencovsky; david williams; M Field; Ravinder N Maini
Clinical associations of IgG antibodies to the ribonucleoprotein p67 polypeptide in patients with systemic lupus erythematosus.
Annals of the rheumatic diseases 1992;51(12):1313-7.
1992: Cong-Qiu Chu; M Field; E Andrew; D Haskard; M Feldmann; Ravinder N Maini
Detection of cytokines at the site of tuberculin-induced delayed-type hypersensitivity in man.
Clinical and experimental immunology 1992;90(3):522-9.
1992: Bent Deleuran; Cong-Qiu Chu; M Field; Fionula M Brennan; P Katsikis; Eugene Eyo Akujuru; Ravinder N Maini
Localization of interleukin-1 alpha, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage/pannus junction in rheumatoid arthritis.
British journal of rheumatology 1992;31(12):801-9.
1992: SM Brookes; Y A Pandolfino; T J Mitchell; Patrick J W Venables; W G Shattles; D A Clark; A Entwistle; Ravinder N Maini
The immune response to and expression of cross-reactive retroviral gag sequences in autoimmune disease.
British journal of rheumatology 1992;31(11):735-42.
1992: Cong-Qiu Chu; M Field; S Allard; E Abney; Eugene Eyo Akujuru; Ravinder N Maini
Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair.
British journal of rheumatology 1992;31(10):653-61.
1992: Bent Deleuran; Cong-Qiu Chu; M Field; Fionula M Brennan; T Mitchell; Eugene Eyo Akujuru; Ravinder N Maini
Localization of tumor necrosis factor receptors in the synovial tissue and cartilage-pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor alpha.
Arthritis and rheumatism 1992;35(10):1170-8.
1992: A P Cope; D Aderka; M Doherty; Hartmut Engelmann; D Gibbons; A C Jones; Fionula M Brennan; Ravinder N Maini; David Wallach; Eugene Eyo Akujuru
Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases.
Arthritis and rheumatism 1992;35(10):1160-9.
1992: C M Brown; C Longhurst; G Haynes; C Plater-Zyberk; A Malcolm; Ravinder N Maini
Immunoglobulin heavy chain variable region gene utilization by B cell hybridomas derived from rheumatoid synovial tissue.
Clinical and experimental immunology 1992;89(2):230-8.
1992: W G Shattles; SM Brookes; Patrick J W Venables; D A Clark; Ravinder N Maini
Expression of antigen reactive with a monoclonal antibody to HTLV-1 P19 in salivary glands in Sjögren's syndrome.
Clinical and experimental immunology 1992;89(1):46-51.
1992: Fionula M Brennan; D L Gibbons; T Mitchell; A P Cope; Ravinder N Maini; Eugene Eyo Akujuru
Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints.
European journal of immunology 1992;22(7):1907-12.
1992: A P Cope; A Jones; M Brozovic; M S Shafi; Ravinder N Maini
Possible induction of systemic lupus erythematosus by human parvovirus.
Annals of the rheumatic diseases 1992;51(6):803-4.
1992: Richard O Williams; C Plater-Zyberk; david williams; Ravinder N Maini
Successful transfer of collagen-induced arthritis to severe combined immunodeficient (SCID) mice.
Clinical and experimental immunology 1992;88(3):455-60.
1992: C Plater-Zyberk; C M Brown; E M Andrew; Ravinder N Maini
CD5+B in rheumatoid arthritis.
Annals of the New York Academy of Sciences 1992;651():540-50.
1992: Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
TNF alpha--a pivotal role in rheumatoid arthritis?
British journal of rheumatology 1992;31(5):293-8.
1992: R Q Zheng; E R Abney; Cong-Qiu Chu; M Field; Ravinder N Maini; J R Lamb; Eugene Eyo Akujuru
Detection of in vivo production of tumour necrosis factor-alpha by human thyroid epithelial cells.
Immunology 1992;75(3):456-62.
1992: R O Williams; david williams; Ravinder N Maini
Anti-type II collagen ELISA. Increased disease specificity following removal of anionic contaminants from salt-fractionated type II collagen.
Journal of immunological methods 1992;147(1):93-100.
1992: Eugene Eyo Akujuru; Fionula M Brennan; Richard O Williams; A P Cope; D L Gibbons; P D Katsikis; Ravinder N Maini
Evaluation of the role of cytokines in autoimmune disease: the importance of TNF alpha in rheumatoid arthritis.
Progress in growth factor research 1992;4(3):247-55.
1991: Cong-Qiu Chu; M Field; E Abney; R Q Zheng; S Allard; Eugene Eyo Akujuru; Ravinder N Maini
Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction.
Clinical and experimental immunology 1991;86(3):380-6.
1991: Christina Baboonian; Patrick J W Venables; david williams; R O Williams; Ravinder N Maini
Cross reaction of antibodies to a glycine/alanine repeat sequence of Epstein-Barr virus nuclear antigen-1 with collagen, cytokeratin, and actin.
Annals of the rheumatic diseases 1991;50(11):772-5.
1991: C Haworth; Fionula M Brennan; David Chantry; M Turner; Ravinder N Maini; Eugene Eyo Akujuru
Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha.
European journal of immunology 1991;21(10):2575-9.
1991: P J Charles; J R Markwick; Patrick J W Venables; Ravinder N Maini
The association between HLA-DR3 and antibodies to the nuclear ribonucleoprotein La: differences between patients from northern Europe and those from the Indian subcontinent.
Disease markers 1991;9(5):297-9.
1991: S A Allard; K D Muirden; Ravinder N Maini
Correlation of histopathological features of pannus with patterns of damage in different joints in rheumatoid arthritis.
Annals of the rheumatic diseases 1991;50(5):278-83.
1991: P J Charles; M C Sweatman; J R Markwick; Ravinder N Maini
HLA-B40: a marker for susceptibility to lung disease in rheumatoid arthritis.
Disease markers 1991;9(2):97-101.
1991: A C Horsfall; Patrick J W Venables; P V Taylor; Ravinder N Maini
Ro and La antigens and maternal anti-La idiotype on the surface of myocardial fibres in congenital heart block.
Journal of autoimmunity 1991;4(1):165-76.
1991: Martin Stocks; david williams; Ravinder N Maini
Analysis of a positive feedback mechanism in the anti-Sm autoantibody response of MRL/MPJ-lpr/lpr mice.
European journal of immunology 1991;21(2):267-72.
1991: R Q Zheng; E Abney; Cong-Qiu Chu; M Field; Beatrix Grubeck-Loebenstein; Ravinder N Maini; Eugene Eyo Akujuru
Detection of interleukin-6 and interleukin-1 production in human thyroid epithelial cells by non-radioactive in situ hybridization and immunohistochemical methods.
Clinical and experimental immunology 1991;83(2):314-9.
1991: Fionula M Brennan; M Field; Cong-Qiu Chu; Eugene Eyo Akujuru; Ravinder N Maini
Cytokine expression in rheumatoid arthritis.
British journal of rheumatology 1991;30 Suppl 1():76-80.
1991: Patrick J W Venables; david williams; A C Horsfall; R O Williams; Martin Stocks; Ravinder N Maini
The immune response to autoantigens and viruses in rheumatic disease.
British journal of rheumatology 1991;30 Suppl 1():70-4.
1991: E M Andrew; C Plater-Zyberk; C M Brown; david williams; Ravinder N Maini
The potential role of B-lymphocytes in the pathogenesis of rheumatoid arthritis.
British journal of rheumatology 1991;30 Suppl 1():47-52.
1990: R Q Zheng; E R Abney; Beatrix Grubeck-Loebenstein; C Dayan; Ravinder N Maini; Eugene Eyo Akujuru
Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-3 on human thyroid epithelial cells in Graves' and Hashimoto's diseases.
Journal of autoimmunity 1990;3(6):727-36.
1990: Christina Baboonian; Patrick J W Venables; Ravinder N Maini; H O Kangro; H K Osman
Antibodies to human herpesvirus-6 in Sjögren's syndrome.
Arthritis and rheumatism 1990;33(11):1749-50.
1990: D Sethi; T C Morgan; Edwina A Brown; N R Cary; C C Erhardt; M Pazianas; Ravinder N Maini; D F Woodrow; P E Gower
Dialysis arthropathy: a clinical, biochemical, radiological and histological study of 36 patients.
The Quarterly journal of medicine 1990;77(282):1061-82.
1990: Fionula M Brennan; C O Zachariae; David Chantry; C G Larsen; M Turner; Ravinder N Maini; K Matsushima; Eugene Eyo Akujuru
Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells.
European journal of immunology 1990;20(9):2141-4.
1990: Ravinder N Maini; C Plater-Zyberk; C M Brown; S Aghamohammadi; Fionula M Brennan; Eugene Eyo Akujuru
CD5+B cells in rheumatoid arthritis and Sjögren's syndrome.
Clinical and experimental rheumatology 1990;8 Suppl 5():67-8.
1990: C M Brown; C Plater-Zyberk; R A Mageed; R Jefferis; Ravinder N Maini
Analysis of immunoglobulins secreted by hybridomas derived from rheumatoid synovia.
Clinical and experimental immunology 1990;80(3):366-72.
1990: D E Barkley; M Feldmann; Ravinder N Maini
Cells with dendritic morphology and bright interleukin-1 alpha staining circulate in the blood of patients with rheumatoid arthritis.
Clinical and experimental immunology 1990;80(1):25-31.
1990: E M Andrew; W Annis; M Kahan; Ravinder N Maini
CD5 (Ly-1)-negative, conventional splenic B cells make a substantial contribution to the bromelain plaque-forming cell response in CBA and BW mice.
Immunology 1990;69(4):515-8.
1990: J W Bijlsma; C Plater-Zyberk; P Mumford; Ravinder N Maini
Lack of natural antibodies in rheumatic diseases.
Rheumatology international 1990;10(3):107-12.
1989: Ravinder N Maini
Heberden Oration, 1988. Exploring immune pathways in rheumatoid arthritis.
British journal of rheumatology 1989;28(6):466-79.
1989: M Field; R D Melsom; Fionula M Brennan; david williams; L Schreiber; Desmond A McCarthy; Ravinder N Maini; R D Nelsom
Rapid clearance of the lupus antigen Sm is delayed by autoantibody: a possible mechanism of autoimmunity perpetuation.
Clinical and experimental immunology 1989;78(3):460-4.
1989: Christina Baboonian; Patrick J W Venables; J Booth; david williams; L M Roffe; Ravinder N Maini
Virus infection induces redistribution and membrane localization of the nuclear antigen La (SS-B): a possible mechanism for autoimmunity.
Clinical and experimental immunology 1989;78(3):454-9.
1989: A C Horsfall; L M Rose; Ravinder N Maini
Autoantibody synthesis in salivary glands of Sjögren's syndrome patients.
Journal of autoimmunity 1989;2(4):559-68.
1989: D Barkley; S Allard; M Feldmann; Ravinder N Maini
Increased expression of HLA-DQ antigens by interstitial cells and endothelium in the synovial membrane of rheumatoid arthritis patients compared with reactive arthritis patients.
Arthritis and rheumatism 1989;32(8):955-63.
1989: Patrick J W Venables; Christina Baboonian; A C Horsfall; D Halliday; Ravinder N Maini; C G Teo; R Mageed; G Millman
The response to Epstein-Barr virus infection in Sjögren's syndrome.
Journal of autoimmunity 1989;2(4):439-48.
1989: F Brennan; C Plater-Zyberk; Ravinder N Maini; Eugene Eyo Akujuru
Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjögren's syndrome.
Clinical and experimental immunology 1989;77(2):175-8.
1989: Fionula M Brennan; David Chantry; Andrew Jackson; Ravinder N Maini; Eugene Eyo Akujuru
Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis.
Lancet 1989;2(8657):244-7.
1989: D Barkley; M Feldmann; Ravinder N Maini
The detection by immunofluorescence of distinct cell populations producing interleukin-1 alpha and interleukin-1 beta in activated human peripheral blood.
Journal of immunological methods 1989;120(2):277-83.
1989: Patrick J W Venables; Christina Baboonian; Ravinder N Maini
Normal serologic response to Epstein-Barr virus in patients with Sjögren's syndrome.
Arthritis and rheumatism 1989;32(6):811-2.
1989: Fionula M Brennan; David Chantry; Andrew Jackson; Ravinder N Maini; Eugene Eyo Akujuru
Cytokine production in culture by cells isolated from the synovial membrane.
Journal of autoimmunity 1989;2 Suppl():177-86.
1989: C Plater-Zyberk; Fionula M Brennan; Eugene Eyo Akujuru; Ravinder N Maini
'Fetal-type' B and T lymphocytes in rheumatoid arthritis and primary Sjögren's syndrome.
Journal of autoimmunity 1989;2 Suppl():233-41.
1989: R A Hughes; S A Allard; Ravinder N Maini
Arthritis associated with adjuvant mycobacterial treatment for carcinoma of the bladder.
Annals of the rheumatic diseases 1989;48(5):432-4.
1989: C T Pease; W Shattles; P J Charles; Patrick J W Venables; Ravinder N Maini
Clinical, serological, and HLA phenotype subsets in Sjögren's syndrome.
Clinical and experimental rheumatology 1989;7(2):185-90.
1989: Patrick J W Venables; W Shattles; C T Pease; J E Ellis; P J Charles; Ravinder N Maini
Anti-La (SS-B): a diagnostic criterion for Sjögren's syndrome?
Clinical and experimental rheumatology 1989;7(2):181-4.
1989: C C Erhardt; P A Mumford; Patrick J W Venables; Ravinder N Maini
Factors predicting a poor life prognosis in rheumatoid arthritis: an eight year prospective study.
Annals of the rheumatic diseases 1989;48(1):7-13.
1989: A M Kissonerghis; Ravinder N Maini; Eugene Eyo Akujuru
High rate of HLA class II mRNA synthesis in rheumatoid arthritis joints and its persistence in culture: down-regulation by recombinant interleukin 2.
Scandinavian journal of immunology 1989;29(1):73-82.
1989: David Chantry; C G Winearls; Ravinder N Maini; Eugene Eyo Akujuru
Mechanism of immune complex-mediated damage: induction of interleukin 1 by immune complexes and synergy with interferon-gamma and tumor necrosis factor-alpha.
European journal of immunology 1989;19(1):189-92.
1989: Christina Baboonian; D Halliday; Patrick J W Venables; T Pawlowski; G Millman; Ravinder N Maini
Antibodies in rheumatoid arthritis react specifically with the glycine alanine repeat sequence of Epstein-Barr nuclear antigen-1.
Rheumatology international 1989;9(3-5):161-6.
1989: R Misra; Patrick J W Venables; C Plater-Zyberk; P F Watkins; Ravinder N Maini
Anti-cardiolipin antibodies in infectious mononucleosis react with the membrane of activated lymphocytes.
Clinical and experimental immunology 1989;75(1):35-40.
1989: Marco Londei; C M Savill; A Verhoef; F Brennan; Z A Leech; V Duance; Ravinder N Maini; Eugene Eyo Akujuru
Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(2):636-40.
1988: Toshio Hirano; Toshio Matsuda; M Turner; N Miyasaka; G Buchan; B Tang; K Sato; Masahiko Shimizu; Ravinder N Maini; Eugene Eyo Akujuru
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis.
European journal of immunology 1988;18(11):1797-801.
1988: M Field; david williams; P Charles; Ravinder N Maini
Specificity of anti-Sm antibodies by ELISA for systemic lupus erythematosus: increased sensitivity of detection using purified peptide antigens.
Annals of the rheumatic diseases 1988;47(10):820-5.
1988: G Buchan; K Barrett; M Turner; David Chantry; Ravinder N Maini; Eugene Eyo Akujuru
Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.
Clinical and experimental immunology 1988;73(3):449-55.
1988: F M Brennan; S Allard; Marco Londei; C Savill; A Boylston; S Carrel; Ravinder N Maini; Eugene Eyo Akujuru
Heterogeneity of T cell receptor idiotypes in rheumatoid arthritis.
Clinical and experimental immunology 1988;73(3):417-23.
1988: D Sethi; Edwina A Brown; Ravinder N Maini; P E Gower
Renal transplantation for dialysis arthropathy.
Lancet 1988;2(8608):448-9.
1988: T D Kennedy; C Plater-Zyberk; T A Partridge; D F Woodrow; Ravinder N Maini
Morphometric comparison of synovium from patients with osteoarthritis and rheumatoid arthritis.
Journal of clinical pathology 1988;41(8):847-52.
1988: T D Kennedy; C Plater-Zyberk; T A Partridge; D F Woodrow; Ravinder N Maini
Representative sample of rheumatoid synovium: a morphometric study.
Journal of clinical pathology 1988;41(8):841-6.
1988: Fionula M Brennan; Marco Londei; Andrew Jackson; T Hercend; M B Brenner; Ravinder N Maini; Eugene Eyo Akujuru
T cells expressing gamma delta chain receptors in rheumatoid arthritis.
Journal of autoimmunity 1988;1(4):319-26.
1988: C Plater-Zyberk; K A Rockett; Ravinder N Maini
Spontaneous recovery of the decreased expression in vitro of interleukin 2 receptors in rheumatoid arthritis.
Clinical and experimental immunology 1988;73(1):93-7.
1988: Eugene Eyo Akujuru; Marco Londei; Beatrix Grubeck-Loebenstein; P De Berardinis; Z Leech; M Turner; K Barrett; G Buchan; Ravinder N Maini
Understanding what infiltrating cells do in autoimmunity: combination of cellular and molecular approaches.
Transplantation proceedings 1988;20(2):311-4.
1988: Patrick J W Venables; T Pawlowski; P A Mumford; C Brown; D H Crawford; Ravinder N Maini
Reaction of antibodies to rheumatoid arthritis nuclear antigen with a synthetic peptide corresponding to part of Epstein-Barr nuclear antigen 1.
Annals of the rheumatic diseases 1988;47(4):270-9.
1988: Fionula M Brennan; E M Andrew; david williams; Ravinder N Maini
Anti-nRNP anti-nuclear antibody-secreting cells are represented in the B-lymphocyte repertoire of normal and MRL/MP-lpr/lpr lupus mice.
Immunology 1988;63(2):213-7.
1988: G Buchan; K Barrett; T Fujita; T Taniguchi; Ravinder N Maini; Eugene Eyo Akujuru
Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma.
Clinical and experimental immunology 1988;71(2):295-301.
1988: A C Horsfall; P A Mumford; Patrick J W Venables; Ravinder N Maini
Anti-idiotypic induced suppression of Sjögren's syndrome associated anti-La autoantibody secretion in vitro.
Clinical and experimental immunology 1988;71(1):62-6.
1988: Patrick J W Venables; SP Rigby; P A Mumford; J Markwick; Ravinder N Maini
Autoimmunity to La (SS-B) in vitro is related to HLA-DR3 in healthy subjects.
Annals of the rheumatic diseases 1988;47(1):22-7.
1988: D Sethi; B R Muller; Edwina A Brown; Ravinder N Maini; P E Gower
C-reactive protein in haemodialysis patients with dialysis arthropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1988;3(3):269-71.
1988: E Andrew; W Annis; Ravinder N Maini
Both Ly-1 B cells and conventional B cells make autoantibodies to bromelain-treated autologous erythrocytes.
Advances in experimental medicine and biology 1988;237():119-23.
1988: Eugene Eyo Akujuru; A M Kissonerghis; G Buchan; F Brennan; M Turner; C Haworth; K Barrett; David Chantry; A Ziegler; Ravinder N Maini
Role of HLA class II and cytokine expression in rheumatoid arthritis.
Scandinavian journal of rheumatology. Supplement 1988;76():39-46.
1988: Ravinder N Maini; C P Zyberk
The significance of CD5+ B cells in rheumatic diseases.
Scandinavian journal of rheumatology. Supplement 1988;76():237-42.
1988: S A Allard; Ravinder N Maini; K D Muirden
Cells and matrix expressing cartilage components in fibroblastic tissue in rheumatoid pannus.
Scandinavian journal of rheumatology. Supplement 1988;76():125-9.
1988: A C Horsfall; Patrick J W Venables; S A Allard; Ravinder N Maini
Co-existent anti-La antibodies and rheumatoid factors bear distinct idiotypic markers.
Scandinavian journal of rheumatology. Supplement 1988;75():84-8.
1988: K D Muirden; S A Allard; K Rogers; Ravinder N Maini
Immuno-electron microscopy of chondrocyte-derived cells in the rheumatoid cartilage-pannus junction.
Rheumatology international 1988;8(5):231-4.
1988: Eugene Eyo Akujuru; Marco Londei; Z Leech; F Brennan; C Savill; Ravinder N Maini
Analysis of T cell clones in rheumatoid arthritis.
Springer seminars in immunopathology 1988;10(2-3):157-67.
1988: C Plater-Zyberk; Ravinder N Maini
Phenotypic and functional features of CD5+ B lymphocytes in rheumatoid arthritis.
Scandinavian journal of rheumatology. Supplement 1988;75():76-83.
1987: A C Horsfall; C M Brown; Ravinder N Maini
Purification of human autoantibodies from cross-linked antigen immunosorbents.
Journal of immunological methods 1987;104(1-2):43-9.
1987: M Field; Fionula M Brennan; D McCarthy; P Mumford; Ravinder N Maini
MRL-lpr/lpr mice show an impairment of IgG aggregate removal which relates to parameters of disease activity.
Immunology 1987;61(4):463-7.
1987: Ravinder N Maini; C Plater-Zyberk; E Andrew
Autoimmunity in rheumatoid arthritis. An approach via a study of B lymphocytes.
Rheumatic diseases clinics of North America 1987;13(2):319-38.
1987: S A Allard; K D Muirden; K L Camplejohn; Ravinder N Maini
Chondrocyte-derived cells and matrix at the rheumatoid cartilage-pannus junction identified with monoclonal antibodies.
Rheumatology international 1987;7(4):153-9.
1986: K Selmaj; C Plater-Zyberk; K A Rockett; Ravinder N Maini; R Alam; G D Perkin; F C Rose
Multiple sclerosis: increased expression of interleukin-2 receptors on lymphocytes.
Neurology 1986;36(10):1392-5.
1986: D Jaraquemada; W E R Ollier; J Awad; A Young; A Silman; I M Roitt; M Corbett; Frank C Hay; J A Cosh; Ravinder N Maini
HLA and rheumatoid arthritis: a combined analysis of 440 British patients.
Annals of the rheumatic diseases 1986;45(8):627-36.
1986: M C Sweatman; J R Markwick; P J Charles; S E Jones; J M Prior; Ravinder N Maini; M E Turner-Warwick
Histocompatibility antigens in adult obliterative bronchiolitis with or without rheumatoid arthritis.
Disease markers 1986;4(1-2):19-26.
1986: A C Horsfall; Patrick J W Venables; P A Mumford; Ravinder N Maini
Idiotypes on antibodies to the La (SS-B) antigen are restricted and associated with the antigen binding site.
Clinical and experimental immunology 1986;63(2):395-401.
1986: R D Melsom; A C Horsfall; L Schrieber; P Charles; Ravinder N Maini
Anti-C1q affinity isolated circulating immune complexes correlate with extra-articular rheumatoid disease.
Rheumatology international 1986;6(5):227-31.
1985: Patrick J W Venables; M G Ross; P J Charles; R D Melsom; P D Griffiths; Ravinder N Maini
A seroepidemiological study of cytomegalovirus and Epstein-Barr virus in rheumatoid arthritis and sicca syndrome.
Annals of the rheumatic diseases 1985;44(11):742-6.
1985: Desmond A McCarthy; M Field; P Mumford; B K Pell; E J Holborow; Ravinder N Maini
The production of small IgG aggregates by glutaraldehyde cross-linking.
Journal of immunological methods 1985;82(2):349-58.
1985: Desmond A McCarthy; M Field; P Mumford; S R Moore; E J Holborow; Ravinder N Maini
Soluble IgG aggregates produced by heating remain stable on freeze-drying.
Journal of immunological methods 1985;82(1):155-60.
1985: C Plater-Zyberk; Ravinder N Maini; K Lam; T D Kennedy; G Janossy
A rheumatoid arthritis B cell subset expresses a phenotype similar to that in chronic lymphocytic leukemia.
Arthritis and rheumatism 1985;28(9):971-6.
1985: M Field; Fionula M Brennan; R D Melsom; D McCarthy; P Mumford; Ravinder N Maini
MRL mice show an age-related impairment of IgG aggregate removal from the circulation.
Clinical and experimental immunology 1985;61(1):195-202.
1985: C Plater-Zyberk; K Lam; T D Kennedy; Ravinder N Maini; G Janossy
Increased representation of a subpopulation of early B cells in the peripheral blood of patients with rheumatoid arthritis.
Advances in experimental medicine and biology 1985;186():957-61.
1985: P Mumford; G R Room; Patrick J W Venables; Ravinder N Maini
IgG antibodies to SS-B (La), RNP/Sm and DNA are produced by PWM-stimulated normal human lymphocytes in culture.
Rheumatology international 1985;5(3):109-12.
1985: Ravinder N Maini; P J Charles; Patrick J W Venables
Antinuclear antibodies in the immunotaxonomy of connective tissue diseases.
Scandinavian journal of rheumatology. Supplement 1985;56():49-57.
1984: W E R Ollier; Patrick J W Venables; P A Mumford; Ravinder N Maini; J Awad; D Jaraquemada; J D'Amaro; H Festenstein
HLA antigen associations with extra-articular rheumatoid arthritis.
Tissue antigens 1984;24(5):279-91.
1984: J R Chapman; P J Charles; Patrick J W Venables; P J Thompson; P L Haslam; Ravinder N Maini; M E Turner Warwick
Definition and clinical relevance of antibodies to nuclear ribonucleoprotein and other nuclear antigens in patients with cryptogenic fibrosing alveolitis.
The American review of respiratory disease 1984;130(3):439-43.
1984: L Schrieber; R D Melsom; Patrick J W Venables; Desmond A McCarthy; Ravinder N Maini
Specific autoantibody slows the rapid plasma clearance of 125I-SS-B (La) in mice.
Clinical and experimental immunology 1984;56(3):621-7.
1984: C C Erhardt; P Mumford; Ravinder N Maini
Differences in immunochemical characteristics of cryoglobulins in rheumatoid arthritis and systemic lupus erythematosus and their complement binding properties.
Annals of the rheumatic diseases 1984;43(3):451-6.
1984: L Schrieber; R D Melsom; Patrick J W Venables; Ravinder N Maini
Tissue uptake and catabolic studies of 125I SS-B (La) injected into mice.
Clinical immunology and immunopathology 1984;31(1):24-32.
1983: C Plater-Zyberk; M F Clarke; K Lam; P A Mumford; G R Room; Ravinder N Maini
In vitro immunoglobulin synthesis by lymphocytes from patients with rheumatoid arthritis. I. Effect of monocyte depletion and demonstration of an increased proportion of lymphocytes forming rosettes with mouse erythrocytes.
Clinical and experimental immunology 1983;52(3):505-11.
1983: L Schrieber; C C Erhardt; R D Melsom; Patrick J W Venables; Desmond A McCarthy; P A Mumford; A C Horsfall; Ravinder N Maini
In vivo fate of 125I SS-B (La) injected into mice.
Immunology 1983;48(4):771-8.
1983: Patrick J W Venables; P J Charles; R R Buchanan; T Yi; P A Mumford; L Schrieber; G R Room; Ravinder N Maini
Quantitation and detection of isotypes of anti-SS-B antibodies by ELISA and Farr assays using affinity purified antigens. An approach to the investigation of Sjögren's syndrome and systemic lupus erythematosus.
Arthritis and rheumatism 1983;26(2):146-55.
1983: R R Buchanan; Patrick J W Venables; A Morgan; N A Staines; P R Smith; Ravinder N Maini
Separation of two molecular species of the Sm antigen by affinity chromatography with murine monoclonal and human anti-nuclear autoantibodies.
Clinical and experimental immunology 1983;51(1):8-16.
1982: G R Room; C Plater-Zyberk; M F Clarke; Ravinder N Maini
B-lymphocyte subpopulation which forms rosettes with mouse erythrocytes increased in rheumatoid arthritis.
Rheumatology international 1982;2(4):175-8.
1981: Patrick J W Venables; L M Roffe; C C Erhardt; Ravinder N Maini; J M Edwards; A D Porter
Titers of antibodies to RANA in rheumatoid arthritis and normal sera. Relationship to Epstein-Barr virus infection.
Arthritis and rheumatism 1981;24(12):1459-68.
1981: Patrick J W Venables; P A Mumford; Ravinder N Maini
Antibodies to nuclear antigens in polymyositis: relationship to autoimmune 'overlap syndromes' and carcinoma.
Annals of the rheumatic diseases 1981;40(3):217-23.
1981: A C Horsfall; Patrick J W Venables; P A Mumford; Ravinder N Maini
Interpretation of the Raji cell assay in sera containing anti-nuclear antibodies and immune complexes.
Clinical and experimental immunology 1981;44(2):405-15.
1981: D McCarthy; D H Goddard; E J Holborow; A C Horsfall; P A Mumford; Ravinder N Maini
The effect of IgG aggregate size and concentration on reactivity in immune complex assays.
Journal of immunological methods 1981;47(3):349-58.
1980: Patrick J W Venables; C C Erhardt; Ravinder N Maini
Antibodies to extractable nuclear antigens in rheumatoid arthritis: relationship to vasculitis and circulating immune complexes.
Clinical and experimental immunology 1980;39(1):146-53.