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Matilde Maiorino

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Valentina Bosello-Travain; Marcus Conrad; Giorgio Cozza; Alessandro Negro; Silvia Quartesan; Monica Rossetto; Antonella Roveri; Stefano Toppo; Fulvio Ursini; Mattia Zaccarin; Matilde Maiorino
Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.
Alexander M Mannes; Alexander Seiler; Valentina Bosello; Matilde Maiorino; Marcus Conrad
Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.
Fulvio Ursini; Matilde Maiorino
Redox pioneer: Professor Leopold Flohé.

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All Publications

2013: Valentina Bosello-Travain; Marcus Conrad; Giorgio Cozza; Alessandro Negro; Silvia Quartesan; Monica Rossetto; Antonella Roveri; Stefano Toppo; Fulvio Ursini; Mattia Zaccarin; Matilde Maiorino
Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.
Biochimica et biophysica acta 2013;1830(6):3846-57.
2011: Alexander M Mannes; Alexander Seiler; Valentina Bosello; Matilde Maiorino; Marcus Conrad
Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(7):2135-44.
2010: Fulvio Ursini; Matilde Maiorino
Redox pioneer: Professor Leopold Flohé.
Antioxidants & redox signaling 2010;13(10):1617-22.
2010: Pierluigi Mauri; Stefano Toppo; Antonella De Palma; Louise Benazzi; Matilde Maiorino; Fulvio Ursini
Identification by MS/MS of disulfides produced by a functional redox transition.
Methods in enzymology 2010;473():217-25.
2009: Stefano Toppo; Leopold Flohé; Ursini Fulvio; Stefano Vanin; Matilde Maiorino
Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme.
Biochimica et biophysica acta 2009;1790(11):1486-500.
2009: Manuela Schneider; Heidi Förster; Auke Boersma; Alexander Seiler; Helga Wehnes; Fred Sinowatz; Christine Neumüller; Manuel J Deutsch; Axel Walch; Martin Hrabé De Angelis; Wolfgang Wurst; Fulvio Ursini; Antonella Roveri; Marek Maleszewski; Matilde Maiorino; Marcus Conrad
Mitochondrial glutathione peroxidase 4 disruption causes male infertility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(9):3233-42.
2008: Silvio C E Tosatto; Valentina Bosello; Federico Fogolari; Pierluigi Mauri; Antonella Roveri; Stefano Toppo; Leopold Flohé; Fulvio Ursini; Matilde Maiorino
The catalytic site of glutathione peroxidases.
Antioxidants & redox signaling 2008;10(9):1515-26.
2008: Antonella Roveri; Maria Pia Vitale; Elena Serain; Mattia Zaccarin; Pierluigi Mauri; Dario Di Silvestre; Antonella De Palma; Massimo Gion; Stefano Toppo; Matilde Maiorino; Fulvio Ursini
Differential liquid phase proteomic analysis of the effect of selenium supplementation in LNCaP cells.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;865(1-2):63-73.
2008: Stefano Toppo; Antonella Roveri; Maria Pia Vitale; Mattia Zaccarin; Elena Serain; Emanuele Apostolidis; Massimo Gion; Matilde Maiorino; Fulvio Ursini
MPA: a multiple peak alignment algorithm to perform multiple comparisons of liquid-phase proteomic profiles.
Proteomics 2008;8(2):250-3.
2007: Matilde Maiorino; Fulvio Ursini; Valentina Bosello; Stefano Toppo; Silvio C E Tosatto; Pierluigi Mauri; Katja Becker; Antonella Roveri; Cristiana Bulato; Louise Benazzi; Antonella De Palma; Leopold Flohé
The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases.
Journal of molecular biology 2007;365(4):1033-46.
2007: Cristiana Bulato; Valentina Bosello; Fulvio Ursini; Matilde Maiorino
Effect of mercury on selenium utilization and selenoperoxidase activity in LNCaP cells.
Free radical biology & medicine 2007;42(1):118-23.
2005: Matilde Maiorino; Antonella Roveri; Louise Benazzi; Valentina Bosello; Pierluigi Mauri; Stefano Toppo; Silvio C E Tosatto; Fulvio Ursini
Functional interaction of phospholipid hydroperoxide glutathione peroxidase with sperm mitochondrion-associated cysteine-rich protein discloses the adjacent cysteine motif as a new substrate of the selenoperoxidase.
The Journal of biological chemistry 2005;280(46):38395-402.
2005: Marcus Conrad; Stéphanie G Moreno; Fred Sinowatz; Ursini Fulvio; Sabine Kölle; Antonella Roveri; Markus Brielmeier; Wolfgang Wurst; Matilde Maiorino; Georg W Bornkamm
The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability.
Molecular and cellular biology 2005;25(17):7637-44.
2005: Andrea Garolla; Matilde Maiorino; Alberto Roverato; Antonella Roveri; Fulvio Ursini; Carlo Foresta
Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels.
Fertility and sterility 2005;83(2):355-61.
2005: Fulvio Ursini; Matilde Maiorino
Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR) does not differ between normo- and hypomotile human sperm samples.
International journal of andrology 2005;28(1):61-2; author reply 63-4.
2005: Matilde Maiorino; Pierluigi Mauri; Antonella Roveri; Louise Benazzi; Stefano Toppo; Valentina Bosello; Fulvio Ursini
Primary structure of the nuclear forms of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in rat spermatozoa.
FEBS letters 2005;579(3):667-70.
2003: Matilde Maiorino; Margherita Scapin; Fulvio Ursini; Mariangela Biasolo; Valentina Bosello; Leopold Flohé
Distinct promoters determine alternative transcription of gpx-4 into phospholipid-hydroperoxide glutathione peroxidase variants.
The Journal of biological chemistry 2003;278(36):34286-90.
2003: Pierluigi Mauri; Louise Benazzi; Leopold Flohé; Matilde Maiorino; Piergiorgio Pietta; Sandra Pilawa; Antonella Roveri; Fulvio Ursini
Versatility of selenium catalysis in PHGPx unraveled by LC/ESI-MS/MS.
Biological chemistry 2003;384(4):575-88.
2003: Matilde Maiorino; Valentina Bosello; Fulvio Ursini; Carlo Foresta; Andrea Garolla; Margherita Scapin; Helena Sztajer; Leopold Flohe
Genetic variations of gpx-4 and male infertility in humans.
Biology of reproduction 2003;68(4):1134-41.
2002: Leopold Flohé; Carlo Foresta; Andrea Garolla; Matilde Maiorino; Antonella Roveri; Fulvio Ursini
Metamorphosis of the selenoprotein PHGPx during spermatogenesis.
Annals of the New York Academy of Sciences 2002;973():287-8.
2002: Carlo Foresta; Leopold Flohé; Andrea Garolla; Antonella Roveri; Fulvio Ursini; Matilde Maiorino
Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase.
Biology of reproduction 2002;67(3):967-71.
2002: Fulvio Ursini; Kelvin J A Davies; Matilde Maiorino; Tiziana Parasassi; Alex Sevanian
Atherosclerosis: another protein misfolding disease?
Trends in molecular medicine 2002;8(8):370-4.
2002: Matilde Maiorino; Fulvio Ursini
Oxidative stress, spermatogenesis and fertility.
Biological chemistry 2002;383(3-4):591-7.
2002: Antonella Roveri; Leopold Flohé; Matilde Maiorino; Fulvio Ursini
Phospholipid-hydroperoxide glutathione peroxidase in sperm.
Methods in enzymology 2002;347():208-12.
2001: Antonella Roveri; Fulvio Ursini; Leopold Flohé; Matilde Maiorino
PHGPx and spermatogenesis.
BioFactors (Oxford, England) 2001;14(1-4):213-22.
2000: A M Pastorino; Matilde Maiorino; Fulvio Ursini
Kinetic analysis of lipid-hydroperoxides in plasma.
Free radical biology & medicine 2000;29(5):397-402.
2000: Leopold Flohé; J R Andreesen; Regina Brigelius-Flohé; Matilde Maiorino; Fulvio Ursini
Selenium, the element of the moon, in life on earth.
IUBMB life 2000;49(5):411-20.
2000: R Tolando; A Jovanovic; Regina Brigelius-Flohé; Fulvio Ursini; Matilde Maiorino
Reactive oxygen species and proinflammatory cytokine signaling in endothelial cells: effect of selenium supplementation.
Free radical biology & medicine 2000;28(6):979-86.
1999: Fulvio Ursini; S Heim; M Kiess; Matilde Maiorino; Antonella Roveri; Josef Wissing; Leopold Flohé
Dual function of the selenoprotein PHGPx during sperm maturation.
Science (New York, N.Y.) 1999;285(5432):1393-6.
1999: Matilde Maiorino; Leopold Flohé; Antonella Roveri; Peter Steinert; Josef Wissing; Fulvio Ursini
Selenium and reproduction.
BioFactors (Oxford, England) 1999;10(2-3):251-6.
1999: A M Pastorino; A Zamburlini; L Zennaro; Matilde Maiorino; Fulvio Ursini
Measurement of lipid hydroperoxides in human plasma and lipoproteins by kinetic analysis of photon emission.
Methods in enzymology 1999;300():33-43.
1998: Matilde Maiorino; Josef Wissing; Regina Brigelius-Flohé; F Calabrese; Antonella Roveri; Peter Steinert; Fulvio Ursini; Leopold Flohé
Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(13):1359-70.
1998: Fulvio Ursini; A Zamburlini; G Cazzolato; Matilde Maiorino; Gabriele Bittolo Bon; Alex Sevanian
Postprandial plasma lipid hydroperoxides: a possible link between diet and atherosclerosis.
Free radical biology & medicine 1998;25(2):250-2.
1998: Franco Tubaro; Andrea Ghiselli; P Rapuzzi; Matilde Maiorino; Fulvio Ursini
Analysis of plasma antioxidant capacity by competition kinetics.
Free radical biology & medicine 1998;24(7-8):1228-34.
1998: Matilde Maiorino; KD Aumann; Regina Brigelius-Flohé; D Doria; J van den Heuvel; J McCarthy; Antonella Roveri; Fulvio Ursini; Leopold Flohé
Probing the presumed catalytic triad of a selenium-containing peroxidase by mutational analysis.
Zeitschrift für Ernährungswissenschaft 1998;37 Suppl 1():118-21.
1998: S Maurer; C Friedrich; M Leist; Matilde Maiorino; Regina Brigelius-Flohé
Attempt to differentiate between individual glutathione peroxidases in biological samples.
Zeitschrift für Ernährungswissenschaft 1998;37 Suppl 1():110-3.
1997: Fulvio Ursini; Matilde Maiorino; Antonella Roveri
Phospholipid hydroperoxide glutathione peroxidase (PHGPx): more than an antioxidant enzyme?
Biomedical and environmental sciences : BES 1997;10(2-3):327-32.
1997: Matilde Maiorino; R Pierce; Leopold Flohé
Product of the Schistosoma mansoni glutathione peroxidase gene is a selenium containing phospholipid hydroperoxide glutathione peroxidase (PHGPx) sharing molecular weight and substrate specificity with its mammalian counterpart.
Biomedical and environmental sciences : BES 1997;10(2-3):209-13.
1997: Alex Sevanian; Gabriele Bittolo Bon; G Cazzolato; Howard N Hodis; Juliana Hwang; A Zamburlini; Matilde Maiorino; Fulvio Ursini
LDL- is a lipid hydroperoxide-enriched circulating lipoprotein.
Journal of lipid research 1997;38(3):419-28.
1996: Matilde Maiorino; C Roche; M Kiess; K Koenig; D Gawlik; M Matthes; E Naldini; R Pierce; Leopold Flohé
A selenium-containing phospholipid-hydroperoxide glutathione peroxidase in Schistosoma mansoni.
European journal of biochemistry / FEBS 1996;238(3):838-44.
1995: A Zamburlini; Matilde Maiorino; P Barbera; Antonella Roveri; Fulvio Ursini
Direct measurement by single photon counting of lipid hydroperoxides in human plasma and lipoproteins.
Analytical biochemistry 1995;232(1):107-13.
1995: Matilde Maiorino; K D Aumann; Regina Brigelius-Flohé; D Doria; J van den Heuvel; J McCarthy; Antonella Roveri; Fulvio Ursini; Leopold Flohé
Probing the presumed catalytic triad of selenium-containing peroxidases by mutational analysis of phospholipid hydroperoxide glutathione peroxidase (PHGPx).
Biological chemistry Hoppe-Seyler 1995;376(11):651-60.
1995: A Zamburlini; Matilde Maiorino; P Barbera; Antonio M Pastorino; Antonella Roveri; Luciano Cominacini; Fulvio Ursini
Measurement of lipid hydroperoxides in plasma lipoproteins by a new highly-sensitive 'single photon counting' luminometer.
Biochimica et biophysica acta 1995;1256(2):233-40.
1995: Matilde Maiorino; A Zamburlini; Antonella Roveri; Fulvio Ursini
Copper-induced lipid peroxidation in liposomes, micelles, and LDL: which is the role of vitamin E?
Free radical biology & medicine 1995;18(1):67-74.
1995: Fulvio Ursini; Matilde Maiorino; Regina Brigelius-Flohé; K D Aumann; Antonella Roveri; Dietmar Schomburg; Leopold Flohé
Diversity of glutathione peroxidases.
Methods in enzymology 1995;252():38-53.
1994: Antonella Roveri; Matilde Maiorino; C Nisii; Fulvio Ursini
Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrial membranes.
Biochimica et biophysica acta 1994;1208(2):211-21.
1994: Matilde Maiorino; Fulvio Ursini; E Cadenas
Reactivity of metmyoglobin towards phospholipid hydroperoxides.
Free radical biology & medicine 1994;16(5):661-7.
1994: Fulvio Ursini; Matilde Maiorino; P Morazzoni; Antonella Roveri; G Pifferi
A novel antioxidant flavonoid (IdB 1031) affecting molecular mechanisms of cellular activation.
Free radical biology & medicine 1994;16(5):547-53.
1994: Antonio M Pastorino; Luciano Cominacini; Matilde Maiorino; Mario Campagnola; Ulisse Garbin; Anna Davoli; A De Santis; Vincenzo Lo Cascio
Effect of plasma on the degradation of hydroperoxides of unesterified linoleic acid and copper-peroxidized LDL.
Free radical biology & medicine 1994;16(4):459-63.
1994: Regina Brigelius-Flohé; K D Aumann; H Blöcker; G Gross; M Kiess; K D Klöppel; Matilde Maiorino; Antonella Roveri; R Schuckelt; F Usani
Phospholipid-hydroperoxide glutathione peroxidase. Genomic DNA, cDNA, and deduced amino acid sequence.
The Journal of biological chemistry 1994;269(10):7342-8.
1994: Antonella Roveri; Matilde Maiorino; Fulvio Ursini
Enzymatic and immunological measurements of soluble and membrane-bound phospholipid-hydroperoxide glutathione peroxidase.
Methods in enzymology 1994;233():202-12.
1992: Antonella Roveri; M Coassin; Matilde Maiorino; A Zamburlini; FT van Amsterdam; Emiliangelo Ratti; Fulvio Ursini
Effect of hydrogen peroxide on calcium homeostasis in smooth muscle cells.
Archives of biochemistry and biophysics 1992;297(2):265-70.
1992: Matilde Maiorino; Antonella Roveri; Fulvio Ursini
Antioxidant effect of Ebselen (PZ 51): peroxidase mimetic activity on phospholipid and cholesterol hydroperoxides vs free radical scavenger activity.
Archives of biochemistry and biophysics 1992;295(2):404-9.
1992: Andrea Bonanome; Antonio Pagnan; S Biffanti; A Opportuno; F Sorgato; M Dorella; Matilde Maiorino; Fulvio Ursini
Effect of dietary monounsaturated and polyunsaturated fatty acids on the susceptibility of plasma low density lipoproteins to oxidative modification.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(4):529-33.
1992: Antonella Roveri; A Casasco; Matilde Maiorino; P Dalan; A Calligaro; Fulvio Ursini
Phospholipid hydroperoxide glutathione peroxidase of rat testis. Gonadotropin dependence and immunocytochemical identification.
The Journal of biological chemistry 1992;267(9):6142-6.
1992: FT van Amsterdam; Antonella Roveri; Matilde Maiorino; Emiliangelo Ratti; Fulvio Ursini
Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity.
Free radical biology & medicine 1992;12(3):183-7.
1991: Matilde Maiorino; Fong-Fong Chu; Fulvio Ursini; K J Davies; James Doroshow; R Steven Esworthy
Phospholipid hydroperoxide glutathione peroxidase is the 18-kDa selenoprotein expressed in human tumor cell lines.
The Journal of biological chemistry 1991;266(12):7728-32.
1991: Matilde Maiorino; J P Thomas; A W Girotti; Fulvio Ursini
Reactivity of phospholipid hydroperoxide glutathione peroxidase with membrane and lipoprotein lipid hydroperoxides.
Free radical research communications 1991;12-13 Pt 1():131-5.
1991: R Schuckelt; Regina Brigelius-Flohé; Matilde Maiorino; Antonella Roveri; J Reumkens; W Strassburger; Fulvio Ursini; B Wolf; Leopold Flohé
Phospholipid hydroperoxide glutathione peroxidase is a selenoenzyme distinct from the classical glutathione peroxidase as evident from cDNA and amino acid sequencing.
Free radical research communications 1991;14(5-6):343-61.
1990: Matilde Maiorino; C Gregolin; Fulvio Ursini
Phospholipid hydroperoxide glutathione peroxidase.
Methods in enzymology 1990;186():448-57.
1989: L P Zhang; Matilde Maiorino; Antonella Roveri; Fulvio Ursini
Phospholipid hydroperoxide glutathione peroxidase: specific activity in tissues of rats of different age and comparison with other glutathione peroxidases.
Biochimica et biophysica acta 1989;1006(1):140-3.
1989: Matilde Maiorino; M Coassin; Antonella Roveri; Fulvio Ursini
Microsomal lipid peroxidation: effect of vitamin E and its functional interaction with phospholipid hydroperoxide glutathione peroxidase.
Lipids 1989;24(8):721-6.
1989: Antonella Roveri; Roberta Bruni; Aldo Baritussio; M Coassin; M Benevento; Matilde Maiorino; Fulvio Ursini
Antioxidant defences of rabbit alveolar lining fluid.
Respiration; international review of thoracic diseases 1989;55 Suppl 1():68-73.
1989: Renata Barsacchi; M Coassin; Matilde Maiorino; G Pelosi; C Simonelli; Fulvio Ursini
Increased ultra weak chemiluminescence emission from rat heart at postischemic reoxygenation: protective role of vitamin E.
Free radical biology & medicine 1989;6(6):573-9.
1989: Fulvio Ursini; Matilde Maiorino; P Hochstein; L Ernster
Microsomal lipid peroxidation: mechanisms of initiation. The role of iron and iron chelators.
Free radical biology & medicine 1989;6(1):31-6.
1988: Matilde Maiorino; Antonella Roveri; M Coassin; Fulvio Ursini
Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51).
Biochemical pharmacology 1988;37(11):2267-71.
1986: Matilde Maiorino; Antonella Roveri; C Gregolin; Fulvio Ursini
Different effects of Triton X-100, deoxycholate, and fatty acids on the kinetics of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase.
Archives of biochemistry and biophysics 1986;251(2):600-5.
1986: Fulvio Ursini; Matilde Maiorino; C Gregolin
Phospholipid hydroperoxide glutathione peroxidase.
International journal of tissue reactions 1986;8(2):99-103.
1985: Fulvio Ursini; Matilde Maiorino; C Gregolin
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
Biochimica et biophysica acta 1985;839(1):62-70.
1985: Matilde Maiorino; Antonella Roveri; Fulvio Ursini; C Gregolin
Enzymatic determination of membrane lipid peroxidation.
Journal of free radicals in biology & medicine 1985;1(3):203-7.
1984: M Scarpa; A Rigo; Matilde Maiorino; Fulvio Ursini; C Gregolin
Formation of alpha-tocopherol radical and recycling of alpha-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes. An electron paramagnetic resonance study.
Biochimica et biophysica acta 1984;801(2):215-9.
1984: Renata Barsacchi; G Pelosi; P Camici; L Bonaldo; Matilde Maiorino; Fulvio Ursini
Glutathione depletion increases chemiluminescence emission and lipid peroxidation in the heart.
Biochimica et biophysica acta 1984;804(3):356-60.
1983: Renata Barsacchi; P Camici; U Bottigli; Piero A Salvadori; G Pelosi; Matilde Maiorino; Fulvio Ursini
Correlation between hydroperoxide-induced chemiluminescence of the heart and its function.
Biochimica et biophysica acta 1983;762(2):241-7.
1982: Fulvio Ursini; Matilde Maiorino; M Valente; L Ferri; C Gregolin
Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides.
Biochimica et biophysica acta 1982;710(2):197-211.
1981: Fulvio Ursini; Matilde Maiorino; L Ferri; M Valente; C Gregolin
Hydrogen peroxide and hematin in microsomal lipid peroxidation.
Journal of inorganic biochemistry 1981;15(2):163-9.