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Tak Mak

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Erawan Borkham-Kamphorst; Ute Haas; Karlin Raja Karlmark; Tak W Mak; Frank Tacke; Lidia Tihaa; Eddy Van de Leur; Thorsten Berger; Henning W Zimmermann; Ralf Weiskirchen
Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis.
Rachel Sarig; Yehudit Zaltsman; Richard Flavell; Tak W Mak; Richard C Marcellus; Atan Gross
BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts.
Filio Billia; Daniela Grothe; Ludger Hauck; Raymond H Kim; Filip Konecny; Vivek Rao; Tak W Mak
Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo.

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All Publications

2013: Erawan Borkham-Kamphorst; Ute Haas; Karlin Raja Karlmark; Tak W Mak; Frank Tacke; Lidia Tihaa; Eddy Van de Leur; Thorsten Berger; Henning W Zimmermann; Ralf Weiskirchen
Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis.
Biochimica et biophysica acta 2013;1832(5):660-73.
2013: Rachel Sarig; Yehudit Zaltsman; Richard Flavell; Tak W Mak; Richard C Marcellus; Atan Gross
BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts.
The Journal of biological chemistry 2013;288(16):11503.
2013: Filio Billia; Daniela Grothe; Ludger Hauck; Raymond H Kim; Filip Konecny; Vivek Rao; Tak W Mak
Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(15):6085-90.
2013: David R McIlwain; Thorsten Berger; Tak W Mak
Caspase functions in cell death and disease.
Cold Spring Harbor perspectives in biology 2013;5(4):a008656.
2013: N Sanchez-Macedo; K Tsuchihara; S L Berger; D Bungard; N Chang; A Elia; B Faubert; Jianhua Feng; R G Jones; Tak W Mak; E J Rushing; K Zaugg
Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model.
Cell death and differentiation 2013;20(4):659-68.
2013: Philipp A Lang; Tak W Mak; D R McIlwain; B Odermatt; Pamela S Ohashi; Aleksandra A Pandyra; V I Pozdeev; Mike Recher; N Shaabani; H C Xu; R M Zinkernagel; S Kumar Maney; D Brenner; M Grusdat; I S Harris; Dieter Haussinger; H Hengartner; N Honke; E Lang; Karl S Lang
Reactive oxygen species delay control of lymphocytic choriomeningitis virus.
Cell death and differentiation 2013;20(4):649-58.
2013: P T Reilly; W L Teo; S Pettersson; A A Amoyo-Brion; T Berger; C Dominguez-Brauer; A J Elia; G Greicius; M J Low; Tak W Mak
Lipocalin 2 performs contrasting, location-dependent roles in APCmin tumor initiation and progression.
Oncogene 2013;32(10):1233-9.
2013: David R McIlwain; Thorsten Berger; Tak W Mak
Caspase functions in cell death and disease.
Cold Spring Harbor perspectives in medicine 2013;3(3):a008656.
2013: Philipp A Lang; Tak W Mak; Andreas Meryk; Pamela S Ohashi; Mike Recher; Stefanie Scheu; Namir Shaabani; Adrian J Thrasher; Carmen Barthuber; Sarah Booth; Stephanie Borkens; Gerben Bouma; Dirk Brenner; Gillian M Griffiths; Dieter Haussinger; Nadine Honke; Karl S Lang
Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency.
The Journal of allergy and clinical immunology 2013;131(3):815-24.
2013: Karl S Lang; Philipp A Lang; Kyeong-Hee Lee; Louis-Martin Boucher; Pauline Funkner; Joachim R Göthert; Jillian Haight; Dieter Haussinger; Yasumichi Hitoshi; Nadine Honke; Vishal Khairnar; David R McIlwain; Katja Merches; Andreas Meryk; Alexander A Navarini; Garry P Nolan; Pamela S Ohashi; Aleksandra A Pandyra; Linda Z Penn; Vitaly I Pozdeev; Mike Recher; Namir Shaabani; Michael W Tusche; Admar Verschoor; Andrew Wakeham; Annick J You-Ten; Tak W Mak
Involvement of Toso in activation of monocytes, macrophages, and granulocytes.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(7):2593-8.
2013: Priya Darshinee A Issuree; Lionel B Ivashkiv; George D Kalliolias; Philipp A Lang; Tak W Mak; Thorsten Maretzky; David R McIlwain; Sébastien Monette; Kyung-Hyun Park-Min; Xiaoping Qing; Jane E Salmon; Steven L Swendeman; Anna Yarilina; Nikolaus Binder; Keisuke Horiuchi; Carl P Blobel
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.
The Journal of clinical investigation 2013;123(2):928-32.
2013: richard tomasini; Sophie Vasseur; M Wilhelm; P Berthezene; E Calvo; Tak W Mak; Gerry Melino; J Nigri; L Pouyet; V Secq; A K Thakur; Juan L Iovanna
TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses.
Cell death and differentiation 2013;20(2):293-301.
2013: Colin Reardon; Mauricio Rosas-Ballina; Kevin Tracey; Michael W Tusche; Peder S Olofsson; Peder Olofsson; Dirk Brenner; Anne Brüstle; Gordon S Duncan; Tak W Mak
Lymphocyte-derived ACh regulates local innate but not adaptive immunity.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(4):1410-5.
2013: Kirsten Labbus; Tak W Mak; Helmut E Meyer; Ralf Weiskirchen; Thorsten Berger; Erawan Borkham-Kamphorst; Cordelia Geisler; Marc Henning; Ruth Knüchel; Corinna Henkel
Proteomic profiling in Lipocalin 2 deficient mice under normal and inflammatory conditions.
Journal of proteomics 2013;78():188-96.
2013: Magdalena Huber; Katharina Jeltsch; Thomas Kamradt; Nadine Bollig; Dirk Brenner; Anne Brüstle; Thorsten Buch; Anna Guralnik; Christina Heinemann; Sylvia Heink; Tak W Mak; Hans-Willi Mittrücker; Axel Pagenstecher; Olivia Prazeres da Costa; Katharina Reinhard; Josephine Ritter; Björn Tackenberg; Alexander Visekruna; Eva Wittmann; Michael Lohoff
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.
The Journal of clinical investigation 2013;123(1):247-60.
2013: Peiyan Wong; Xiaodong Zhang; Vonny I Leo; Meijun Low; Tak W Mak; Patrick T Reilly
Targeted ANP32E Mutant Mice Do Not Demonstrate Obvious Movement Defects.
PloS one 2013;8(5):e63815.
2013: Amy E Lin; Tak W Mak; Pamela S Ohashi; Yongkai Ow; James P Cooney; Dilan Dissanayake; Gordon Duncan; Gregor Ebert; Raymond H Kim; Simon P Preston; Samuel D Saibil; Masato Sasaki; Hamish W Scott; Arda Shahinian; Jennifer Silvester; Jesse G Toe; Andrew Wakeham; Annick You-Ten; Marc Pellegrini
ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system.
Nature immunology 2013;14(1):27-33.
2012: Gordon S Duncan; Andrew Elia; Christiane B Knobbe; Peter H Krammer; Mark R Bray; Dirk Brenner; Anne Brüstle; Thomas Mock; Michael W Tusche; Tak W Mak
2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(51):21034-9.
2012: Miki Nishio; Fumihito Noguchi; Hiroshi Nojima; Masato Sasaki; Takehiko Sasaki; Satoshi O Suzuki; Masaaki Tokuda; Norikazu Yabuta; Shuhei Chiba; Youyi Dong; Jonathan Eggenschwiler; Koichi Hamada; Yutaka Hata; Hiroki Hikasa; Satoshi Itami; Kohichi Kawahara; Tak W Mak; Koshi Mimori; Kensaku Mizuno; Masaki Mori; Takumi Morikawa; Kentaro Nakagawa; Toru Nakano; Hiroshi Nishina; Akira Suzuki
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.
The Journal of clinical investigation 2012;122(12):4505-18.
2012: Anne Brüstle; Brian M Hershenfield; Christiane B Knobbe; Sonja M Lacher; Philipp A Lang; Pamela S Ohashi; Colin Reardon; Jürgen Ruland; Carl Virtanen; Dirk Brenner; Tak W Mak
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.
The Journal of clinical investigation 2012;122(12):4698-709.
2012: Alvin P Joselin; Raymond H Kim; Tak W Mak; Steven M Callaghan; Young-Hwa Chung; Sarah J Hewitt; Jie Shen; Ruth S Slack; David S Park
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.
Human molecular genetics 2012;21(22):4888-903.
2012: Patrick T Reilly; Tak W Mak
Molecular pathways: tumor cells Co-opt the brain-specific metabolism gene CPT1C to promote survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(21):5850-5.
2012: Youqi Han; Yan Lu; Tak W Mak; Enrico Arpaia; Jie Cui; Stephanie Sue; Mark D Minden
FCHSD2 predicts response to chemotherapy in acute myeloid leukemia patients.
Leukemia research 2012;36(11):1339-46.
2012: Maxime W C Rousseaux; Michael G Schlossmacher; Sarah Seang; ruth slack; Sarah J Hewitt; Raymond H Kim; Diane C Lagace; Tak W Mak; Paul C Marcogliese; Dianbo Qu; David S Park
Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(39):15918-23.
2012: Manu Rangachari; Kaori Sakuishi; Raymond A Sobel; Andrew Wakeham; Sheng Xiao; Chen Zhu; Marylyn M Addo; Ana C Anderson; Mathieu Angin; Andrew Chen; Edward A Greenfield; Jozsef Karman; Tak W Mak; Peter J McKinnon; Hitoshi Okada; Vijay K Kuchroo
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.
Nature medicine 2012;18(9):1394-400.
2012: Masato Sasaki; Stefanie Schalm; Shinsan M Su; Carl Virtanen; Andrew Wakeham; Annick You-Ten; Juan Carlos Zúñiga-Pflücker; Ari Melnick; Joshua C Munger; Pamela S Ohashi; Guido Reifenberger; Dwayne L Barber; Dirk Brenner; Anne Brüstle; Maria E Figueroa; Jillian Haight; Isaac S Harris; Roxanne Holmes; Christiane B Knobbe; Wanda Y Li; Evan F Lind; Tak W Mak
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.
Nature 2012;488(7413):656-9.
2012: Gladys W Wong; Adolfo Ferrando; Gisele C Knowles; Tak W Mak; Juan Carlos Zúñiga-Pflücker
HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.
Blood 2012;120(7):1439-48.
2012: A F Ghiam; Tak W Mak; A Meng; J Thoms; O Ahmed; R A Cairns; A Dal Pra; R G Bristow
IDH mutation status in prostate cancer.
Oncogene 2012;31(33):3826.
2012: Ann J McPherson; Laura M Snell; Tak W Mak; Tania H Watts
Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells.
The Journal of biological chemistry 2012;287(27):23010-9.
2012: Dongwei He; Hironobu Ikehata; Jun-ichiro Komura; Huiying Li; Tak W Mak; Yali Chen; Maiko Furuya; Yoshihiko Uehara; Tetsuya Ono
Role of the Msh2 gene in genome maintenance and development in mouse fetuses.
Mutation research 2012;734(1-2):50-5.
2012: Christopher P Dillon; Tehila Ben-Moshe; Laura J Janke; Tae-Bong Kang; Tak W Mak; Andrew Oberst; David Wallach; Ricardo Weinlich; Douglas R Green
Survival function of the FADD-CASPASE-8-cFLIP(L) complex.
Cell reports 2012;1(5):401-7.
2012: Nadine Bollig; Evita Bothur; Cornelia Brendel; Anne Brüstle; Bärbel Camara; Chen Dong; Alexandra Elli; Gavin Giel; Magdalena Huber; Ralf Jacob; Kerstin Kellner; Richard A Kroczek; Tak W Mak; Roza Nurieva; Christoph Paul; Hartmann Raifer; Elfadil Abass; Waltraud Ackermann; Michael Lohoff
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(22):8664-9.
2012: Rahul D Pawar; Milena Pitashny; Thorsten Berger; Sean R Campbell; Simona Gindea; Beatrice Goilav; Leal Herlitz; Benjamin Levine; Tak W Mak; Xiaoping Qing; David B Thomas; Arlene Tan Tieng; Yumin Xia; Chaim Putterman
Neutrophil gelatinase-associated lipocalin is instrumental in the pathogenesis of antibody-mediated nephritis in mice.
Arthritis and rheumatism 2012;64(5):1620-31.
2012: Feng Wang; Kazuo Yamamoto; Geneviève M C Gasmi-Seabrook; Guang-Yao Li; Tak W Mak; Christopher B Marshall; Hitoshi Okada; Mitsuhiko Ikura
Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):6078-83.
2012: Yiru Zhang; Lei Zhang; Tak W Mak; Yang Mei; Yuqian Xing; Kazuo Yamamoto; Han You
Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(15):5717-22.
2012: Rob A Cairns; Li Chong Chan; Wing-Chung Chan; Laurence de Leval; Philippe Gaulard; Javeed Iqbal; Jean-Philippe Jais; Can Kucuk; François Lemonnier; Antoine Martin; Marie Parrens; Luc Xerri; Pierre Brousset; Tak W Mak
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma.
Blood 2012;119(8):1901-3.
2012: E Arpaia; H Blaser; A Brüstle; G Duncan; C K Fleming; H S Leong; J D Lewis; E F Lind; S C Nambiar; P S Ohashi; Miguel Quintela-Fandino; A Rufini; J Silvester; M W Tusche; A Ablack; Tak W Mak
The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk.
Oncogene 2012;31(7):884-96.
2012: Sophie Vasseur; S Afzal; F Guillaumond; Tak W Mak; Joël Tardivel-Lacombe; richard tomasini; Juan L Iovanna
Consequences of DJ-1 upregulation following p53 loss and cell transformation.
Oncogene 2012;31(5):664-70.
2012: Philipp A Lang; Tak W Mak; Ian A Parish; Ramtin Rahbar; Mike Recher; Namir Shaabani; Charles W Tran; Casey T Weaver; Haifeng C Xu; Anne Brüstle; James R Carlyle; Peter Chen; Salim Dhanji; Andreas Diefenbach; Dilan Dissanayake; Alisha R Elford; Jason Fine; Magar Ghazarian; Melanie Grusdat; Dieter Häussinger; Susan M Kaech; Christoph Klose; Karl S Lang; Pamela S Ohashi
Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(4):1210-5.
2012: Zhenyue Hao; Elias Hobeika; Claire Hong; Andrea Jurisicova; Philipp A Lang; Qinxi Li; Wanda Y Li; Susan McCracken; Pamela S Ohashi; Michael Reth; Yi Sheng; Jennifer Silvester; Yu-Wen Su; Andrew Wakeham; Xiaodong Wang; Han You; Annick You-Ten; Qing Zhong; Dirk Brenner; Jacqui Detmar; Gordon S Duncan; Andrew Elia; Chiara Gorrini; Jillian Haight; Tak W Mak
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
The Journal of experimental medicine 2012;209(1):173-86.
2012: David R McIlwain; Aditya Murthy; Pamela S Ohashi; Kazuhito Ohishi; Andrew Wakeham; Haifeng C Xu; Sathish Kumar Maney; Thorsten Maretzky; Thorsten Berger; Carl P Blobel; Gordon Duncan; Koichi Hamada; Dieter Häussinger; Annick Itie-Youten; Rama Khokha; Karl S Lang; Philipp A Lang; Tak W Mak
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.
Science (New York, N.Y.) 2012;335(6065):229-32.
2012: Tatiana Lipina; Tak W Mak; Alexander McGirr; John C Roder; Thorsten Berger; Paul C Boutros; Fahmida Nipa Haque; Albert H C Wong
Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice.
PloS one 2012;7(12):e51562.
2012: Lokesh Guglani; Beth Fallert Junecko; John F Alcorn; Thorsten Berger; Yvonne Chan; Radha Gopal; Yinyao Lin; Tak W Mak; Troy D Randall; Javier Rangel Moreno; Todd A Reinhart; Shabaana A Khader
Lipocalin 2 regulates inflammation during pulmonary mycobacterial infections.
PloS one 2012;7(11):e50052.
2012: Bo Yang; Jessie Ws Yue; Aimin Xu; Thorsten Berger; Pengcheng Fan; Karen Sl Lam; Tak W Mak; Erfei Song; Gary Sweeney; Hung-Fat Tse; Paul M Vanhoutte; Yu Wang
Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling.
American journal of translational research 2012;4(1):60-71.
2011: Wissam Assaily; Lauren Brown-Endres; Yunping Lin; Weili Ma; Tak W Mak; Daniel A Rubinger; Katsuya Tsuchihara; Keith Wheaton; Wanli Xuan; Samuel Benchimol
ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.
Molecular cell 2011;44(3):491-501.
2011: Wenbin Ma; Tak W Mak; Michael R Blackburn; eliseo fernando castillo; Mary Hall; Sara Herrera-Rodriguez; Morgan McKeller; Hitoshi Okada; Blanca Ortiz-Quintero; Roberto Rangel; Kimberly Schluns; Woong-Kyung Suh; Huiyuan Zhang; Yang Zhou; Hector Martinez-Valdez
Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice.
Cell research 2011;21(11):1564-77.
2011: Mauricio Rosas-Ballina; Michael W Tusche; Sergio I Valdés-Ferrer; Ulf Andersson; Sangeeta Chavan; Yaakov A Levine; Tak W Mak; Mahendar Ochani; Peder S Olofsson; Valentin A Pavlov; Colin Reardon; Kevin Tracey
Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit.
Science (New York, N.Y.) 2011;334(6052):98-101.
2011: Christiane B Knobbe; Tak W Mak; Howard T J Mount; Timothy J Revett; Yu Bai; Christopher Böhm; Vinca Chow; Sepehr Ehsani; Amy Hye Won Jeon; Thomas Kislinger; Peter St George-Hyslop; Gerold Schmitt-Ulms
Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90.
Journal of proteome research 2011;10(10):4388-404.
2011: Melanie G Gareau; Stephen E Girardin; Nathan K Ho; Lionel Lebourhis; Tak W Mak; Dana J Philpott; Dirk Brenner; Andrew J Sousa; Philip M Sherman
Enterohaemorrhagic, but not enteropathogenic, Escherichia coli infection of epithelial cells disrupts signalling responses to tumour necrosis factor-alpha.
Microbiology (Reading, England) 2011;157(Pt 10):2963-73.
2011: Robert Karisch; Tak W Mak; Michael F Moran; Jun Mori; Yotis A Senis; Jonathan R St-Germain; Paul Taylor; Carl Virtanen; Arne Östman; Minerva Fernandez; Isaac S Harris; Lily L Jin; Benjamin G Neel
Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome".
Cell 2011;146(5):826-40.
2011: Julia Fang Gao; Stephen C Juvet; Xujian Li; Tak W Mak; Megan S Ford McIntyre; Ramesh B Vanama; Mark S Cattral; Jun Diao; Li Zhang
Regulation of antigen-expressing dendritic cells by double negative regulatory T cells.
European journal of immunology 2011;41(9):2699-708.
2011: Colin Reardon; Naomi Shuman; Steven F Ziegler; Dana Philpott; Anne Brüstle; Melanie G Gareau; Matthias Lechmann; Tak W Mak
Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation.
Immunity 2011;35(2):223-35.
2011: Samah El Ghamrasni; Ashwin Pamidi; Marie Jo Halaby; Miyuki Bohgaki; Renato Cardoso; Li Li; Shriram Venkatesan; Swaminathan Sethu; Atsushi Hirao; Tak W Mak; M Prakash Hande; Anne Hakem; Raza Hakem
Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.
PLoS genetics 2011;7(5):e1001385.
2011: Alessandro Rufini; Berna S Sayan; Richard Tomasini; Tania Velletri; Massimiliano Agostini; Franco Conforti; Francesca Grespi; Tak W Mak; Antonio Mastino; Gerry Melino; Maria Victoria Niklison-Chirou; Richard A Knight
p73 in Cancer.
Genes & cancer 2011;2(4):491-502.
2011: Arnold J Levine; Richard Tomasini; Frank D McKeon; Tak W Mak; Gerry Melino
The p53 family: guardians of maternal reproduction.
Nature reviews. Molecular cell biology 2011;12(4):259-65.
2011: Richard Killick; Maria Niklison-Chirou; Richard Tomasini; Daniele Bano; Alessandro Rufini; Francesca Grespi; Tania Velletri; Paola Tucci; Berna S Sayan; Franco Conforti; Ewen Gallagher; Pierluigi Nicotera; Tak W Mak; Gerry Melino; Richard A Knight; Massimiliano Agostini
p73: a multifunctional protein in neurobiology.
Molecular neurobiology 2011;43(2):139-46.
2011: Yoshifumi Tada; Seiji Kondo; Shigehisa Aoki; Syuichi Koarada; Hisako Inoue; Rie Suematsu; Akihide Ohta; Tak W Mak; Kohei Nagasawa
Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice.
Arthritis and rheumatism 2011;63(3):738-48.
2011: Marc Pellegrini; Thomas Calzascia; Jesse G Toe; Simon P Preston; Amy E Lin; Alisha R Elford; Arda Shahinian; Philipp A Lang; Karl S Lang; Michel MORRE; Brigitte Assouline; Katharina Lahl; Tim D. Sparwasser; Thomas F Tedder; Ji-Hye Paik; Ronald A DePinho; Sameh Basta; Pamela S Ohashi; Tak W Mak
IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology.
Cell 2011;144(4):601-13.
2011: R Sean McNally; Beckley K Davis; Casey M Clements; Mary Ann Accavitti-Loper; Tak W Mak; Jenny P-Y Ting
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.
The Journal of biological chemistry 2011;286(6):4098-106.
2011: Rob A Cairns; Isaac S Harris; Tak W Mak
Regulation of cancer cell metabolism.
Nature reviews. Cancer 2011;11(2):85-95.
2011: Patrick J Shaw; Maggie J Barr; John R Lukens; Maureen A McGargill; Hongbo Chi; Tak W Mak; Thirumala-Devi Kanneganti
Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity.
Immunity 2011;34(1):75-84.
2011: Yu-Wen Su; Zhenyue Hao; Atsushi Hirao; Kazuo Yamamoto; Wen Jye Lin; Ashley Young; Gordon S Duncan; Hiroki Yoshida; Andrew Wakeham; Philipp A Lang; Kiichi Murakami; Heiko Hermeking; Bert Vogelstein; Pamela S Ohashi; Tak W Mak
14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1555-60.
2011: Masahito Kawazu; Kayoko Saso; Kit I Tong; Tracy McQuire; Kouichiro Goto; Dong-Ok Son; Andrew Wakeham; Makoto Miyagishi; Tak W Mak; Hitoshi Okada
Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.
PloS one 2011;6(3):e17830.
2011: Elize A Shirdel; Wing Xie; Tak W Mak; Igor Jurisica
NAViGaTing the micronome--using multiple microRNA prediction databases to identify signalling pathway-associated microRNAs.
PloS one 2011;6(2):e17429.
2010: Kiichi Murakami; Nicole Liadis; Janice Sarmiento; Alisha R Elford; Minna Woo; Linh T Nguyen; Tak W Mak; Pamela S Ohashi
Caspase 3 is not essential for the induction of anergy or multiple pathways of CD8+ T-cell death.
European journal of immunology 2010;40(12):3372-7.
2010: Linyuan Wang; Yunfeng Liu; Shun Yan Lu; Kinh-Tung T Nguyen; Stephanie A Schroer; Akira Suzuki; Tak W Mak; Herbert Gaisano; Minna Woo
Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes.
Diabetes 2010;59(12):3117-26.
2010: Min Fang; Zhirong Shen; Song Huang; Liping Zhao; She Chen; Tak W Mak; Xiaodong Wang
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.
Cell 2010;143(5):711-24.
2010: Masashi Fujitani; Gonzalo I Cancino; Chandrasagar B Dugani; Ian C G Weaver; Andrée Gauthier-Fisher; Annie Paquin; Tak W Mak; Martin J Wojtowicz; Freda D Miller; David R Kaplan
TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors.
Current biology : CB 2010;20(22):2058-65.
2010: Alexandra Berger; Patricia Benveniste; Steven A Corfe; Anne H Tran; Mary Barbara; Andrew Wakeham; Tak W Mak; Norman N Iscove; Christopher J Paige
Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development.
Blood 2010;116(19):3792-801.
2010: Irene M Patzak; Sebastian Königsberger; Akira Suzuki; Tak W Mak; Friedemann Kiefer
HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion.
European journal of immunology 2010;40(11):3220-5.
2010: Takeshi Ueda; Masato Sasaki; Andrew J Elia; Iok In Christine Chio; Koichi Hamada; Rikiro Fukunaga; Tak W Mak
Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):13984-90.
2010: Saraswati Lassen; Maciej Lech; Christoph Römmele; Hans-Willi Mittruecker; Tak W Mak; Hans-Joachim Anders
Ischemia reperfusion induces IFN regulatory factor 4 in renal dendritic cells, which suppresses postischemic inflammation and prevents acute renal failure.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(3):1976-83.
2010: Marc Pellegrini; Tak W Mak; Pamela S Ohashi
Fighting cancers from within: augmenting tumor immunity with cytokine therapy.
Trends in pharmacological sciences 2010;31(8):356-63.
2010: Nicolas Prevot; Claire Briet; Hans Lassmann; Isabelle Tardivel; Edwige Roy; Joëlle Morin; Tak W Mak; Anna Tafuri; Christian Boitard
Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system.
European journal of immunology 2010;40(8):2267-76.
2010: Berna S Sayan; Ai Li Yang; Franco Conforti; Paola Tucci; Maria Cristina Piro; Gareth J Browne; Massimiliano Agostini; Sergio Bernardini; Richard A Knight; Tak W Mak; Gerry Melino
Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(29):12877-82.
2010: David R McIlwain; Qun Pan; Patrick T Reilly; Andrew Elia; Susan McCracken; Andrew Wakeham; Annick Itie-Youten; Benjamin J Blencowe; Tak W Mak
Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(27):12186-91.
2010: Marc Pellegrini; Tak W Mak
Tumor immune therapy: lessons from infection and implications for cancer - can IL-7 help overcome immune inhibitory networks?
European journal of immunology 2010;40(7):1852-61.
2010: Ivy K M Law; Aimin Xu; Karen S L Lam; Thorsten Berger; Tak W Mak; Paul M Vanhoutte; Jacky T C Liu; Gary Sweeney; Mingyan Zhou; Bo Yang; Yu Wang
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity.
Diabetes 2010;59(4):872-82.
2010: Zhenyue Hao; Tak W Mak
Type I and type II pathways of Fas-mediated apoptosis are differentially controlled by XIAP.
Journal of molecular cell biology 2010;2(2):63-4.
2010: Margareta T Wilhelm; Alessandro Rufini; Monica K Wetzel; Katsuya Tsuchihara; Satoshi Inoue; richard tomasini; Annick Itie-Youten; Andrew Wakeham; Marie Arsenian-Henriksson; Gerry Melino; David R Kaplan; Freda D Miller; Tak W Mak
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.
Genes & development 2010;24(6):549-60.
2010: Miguel Quintela-Fandino; Christophe Le Tourneau; Ignacio Duran; Eric X Chen; Lisa Wang; Ming Tsao; Bizhan Bandarchi-Chamkhaleh; Nhu-Ann Pham; Trevor Do; Martha MacLean; Rakesh Nayyar; Michael W Tusche; Ur Metser; John J Wright; Tak W Mak; Lillian L Siu
Phase I combination of sorafenib and erlotinib therapy in solid tumors: safety, pharmacokinetic, and pharmacodynamic evaluation from an expansion cohort.
Molecular cancer therapeutics 2010;9(3):751-60.
2010: Elissa K Deenick; Alisha R Elford; Marc Pellegrini; Håkan Hall; Tak W Mak; Pamela S Ohashi
c-Rel but not NF-kappaB1 is important for T regulatory cell development.
European journal of immunology 2010;40(3):677-81.
2010: Elissa K Deenick; Leslie Po; Laurence Chapatte; Kiichi Murakami; Yong-Chen Lu; Alisha R Elford; Samuel D Saibil; Jürgen Ruland; Steve Gerondakis; Tak W Mak; Pamela S Ohashi
c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.
European journal of immunology 2010;40(3):867-77.
2010: Geneviève M C Gasmi-Seabrook; Christopher B Marshall; Melissa Cheung; Bryan Kim; Feng Wang; Ying Ju Jang; Tak W Mak; Vuk Stambolic; Mitsuhiko Ikura
Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF.
The Journal of biological chemistry 2010;285(8):5137-45.
2010: Hossein Aleyasin; Rousseaux Maxime; Paul C Marcogliese; Sarah J Hewitt; Isabella Irrcher; Alvin P Joselin; Mohammad Parsanejad; Raymond H Kim; Patrizia Rizzu; Steven M Callaghan; ruth slack; Tak W Mak; David Park
DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3186-91.
2010: Thorsten Berger; Carol C Cheung; Andrew J Elia; Tak W Mak
Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):2995-3000.
2010: Stefan Gross; Rob A Cairns; Mark D Minden; Edward M Driggers; Mark A Bittinger; Hyun Gyung Jang; Masato Sasaki; Shengfang Jin; David P Schenkein; Shinsan M Su; Lenny Dang; Valeria R Fantin; Tak W Mak
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.
The Journal of experimental medicine 2010;207(2):339-44.
2010: Miguel Quintela-Fandino; Enrico Arpaia; Dirk Brenner; Theo Goh; Faith Au Yeung; Heiko Blaser; Roumiana Alexandrova; Evan F Lind; Mike W Tusche; Andrew Wakeham; Pamela S Ohashi; Tak W Mak
HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2622-7.
2010: Jumpei Asano; Hiroyuki Tada; Nobuyuki Onai; Taku Sato; Yasuo Horie; Yukari Fujimoto; Koichi Fukase; Akira Suzuki; Tak W Mak; Toshiaki Ohteki
Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):736-45.
2010: Patrick T Reilly; Samia Afzal; Andrew Wakeham; Jillian Haight; Annick You-Ten; Kathrin Zaugg; Joanna Dembowy; Ashley Young; Tak W Mak
Generation and characterization of the Anp32e-deficient mouse.
PloS one 2010;5(10):e13597.
2009: Shintaro Kamizono; Gordon S Duncan; Markus G Seidel; Akira Morimoto; Koichi Hamada; Gerard Grosveld; Koichi Akashi; Evan F Lind; Jillian P Haight; Pamela S Ohashi; A Thomas Look; Tak W Mak
Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo.
The Journal of experimental medicine 2009;206(13):2977-86.
2009: Feng Wang; Christopher B Marshall; Guang-Yao Li; Kazuo Yamamoto; Tak W Mak; Mitsuhiko Ikura
Synergistic interplay between promoter recognition and CBP/p300 coactivator recruitment by FOXO3a.
ACS chemical biology 2009;4(12):1017-27.
2009: Mathieu Gigoux; Jijun Shang; Youngshil Pak; Minghong Xu; Jongseon Choe; Tak W Mak; Woong-Kyung Suh
Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20371-6.
2009: Dirk Brenner; Tak W Mak
Mitochondrial cell death effectors.
Current opinion in cell biology 2009;21(6):871-7.
2009: Michael W Tusche; Lesley A Ward; Frances Vu; Doug McCarthy; Miguel Quintela-Fandino; Jurgen Ruland; Jennifer L Gommerman; Tak W Mak
Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets.
The Journal of experimental medicine 2009;206(12):2671-83.
2009: Hisako Kayama; Ritsuko Koga; Koji Atarashi; Megumi Okuyama; Taishi Kimura; Tak W Mak; Satoshi Uematsu; Shizuo Akira; Hiroshi Takayanagi; Kenya Honda; Masahiro Yamamoto; Kiyoshi Takeda
NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.
PLoS pathogens 2009;5(7):e1000514.
2009: Colin Reardon; Tak W Mak
cIAP proteins: keystones in NOD receptor signal transduction.
Immunity 2009;30(6):755-6.
2009: Manuela Raffatellu; Michael D George; Yuko Akiyama; Michael J Hornsby; Sean-Paul Nuccio; Tatiane A Paixao; Brian P Butler; Hiutung Chu; Renato L Santos; Thorsten Berger; Tak W Mak; Renée M Tsolis; Charles L Bevins; Jay V Solnick; Satya Dandekar; Andreas J Baumler
Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine.
Cell host & microbe 2009;5(5):476-86.
2009: Marc Pellegrini; Thomas Calzascia; Alisha R Elford; Arda Shahinian; Amy E Lin; Dilan Dissanayake; Salim Dhanji; Linh T Nguyen; Matthew A Gronski; Michel MORRE; Brigitte Assouline; Katharina Lahl; Tim D. Sparwasser; Pamela S Ohashi; Tak W Mak
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.
Nature medicine 2009;15(5):528-36.
2009: Yvonne Chan; Jessica S Liu; Derek A Pociask; Mingquan Zheng; Timothy A Mietzner; Thorsten Berger; Tak W Mak; Matthew C Clifton; Roland K Strong; Prabir Ray; Jay K Kolls
Lipocalin 2 is required for pulmonary host defense against Klebsiella infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4947-56.
2009: Yang Mei; Yiru Zhang; Kazuo Yamamoto; Wei Xie; Tak W Mak; Han You
FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5153-8.
2009: Patrizia Vernole; Michael H Neale; Daniela Barcaroli; Eliana Munarriz; Richard A Knight; Richard Tomasini; Tak W Mak; Gerry Melino; Vincenzo de Laurenzi
TAp73alpha binds the kinetochore proteins Bub1 and Bub3 resulting in polyploidy.
Cell cycle (Georgetown, Tex.) 2009;8(3):421-9.
2009: Anna Radziszewska; Diana Choi; Kinh-Tung T Nguyen; Stephanie A Schroer; Panteha Tajmir; Linyuan Wang; Akira Suzuki; Tak W Mak; Gerard I Evan; Minna Woo
PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells.
The Journal of biological chemistry 2009;284(5):2917-22.
2009: richard tomasini; Katsuya Tsuchihara; Chiharu Tsuda; Suzanne K Lau; Margareta Wilhelm; Alessandro Ruffini; Ming Tsao; Juan L Iovanna; Andrea Jurisicova; Gerry Melino; Tak W Mak
TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):797-802.
2009: Thomas Kaufmann; Philipp J Jost; Marc Pellegrini; Hamsa Puthalakath; Raffi Gugasyan; Steve Gerondakis; Erika Cretney; Mark J Smyth; John Silke; Razq Hakem; Philippe Bouillet; Tak W Mak; Xiaodong Huang; Andreas Strasser
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.
Immunity 2009;30(1):56-66.
2008: Feng Wang; Christopher B Marshall; Kazuo Yamamoto; Guang-Yao Li; Michael J Plevin; Han You; Tak W Mak; Mitsuhiko Ikura
Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53.
Journal of molecular biology 2008;384(3):590-603.
2008: Brian J Zarnegar; Yaya Wang; Douglas J Mahoney; Paul W Dempsey; Herman H Cheung; Jeannie He; Travis Shiba; Xiaolu Yang; Wen-Chen Yeh; Tak W Mak; Robert G Korneluk; Genhong Cheng
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
Nature immunology 2008;9(12):1371-8.
2008: Jin Woo Kim; Kyung Hwa Kang; Patrick Burrola; Tak W Mak; Greg Lemke
Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium.
Genes & development 2008;22(22):3147-57.
2008: Zhenyue Hao; Gordon S Duncan; Jane Seagal; Yu-Wen Su; Claire Hong; Jillian Haight; Nien-Jung Chen; Andrew Elia; Andrew Wakeham; Wanda Y Li; Jennifer Liepa; Geoffrey A Wood; Stefano Casola; Klaus Rajewsky; Tak W Mak
Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.
Immunity 2008;29(4):615-27.
2008: richard tomasini; Katsuya Tsuchihara; Margareta Wilhelm; Masashi Fujitani; Alessandro Rufini; Carol C Cheung; Fatima Khan; Annick Itie-Youten; Andrew Wakeham; Ming Tsao; Juan L Iovanna; Jeremy Squire; Igor Jurisica; David Kaplan; Gerry Melino; Andrea Jurisicova; Tak W Mak
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.
Genes & development 2008;22(19):2677-91.
2008: Julie M Rumble; Mathieu J M Bertrand; Rebecca A Csomos; Casey W Wright; Lori Albert; Tak W Mak; Philip A Barker; Colin S Duckett
Apoptotic sensitivity of murine IAP-deficient cells.
The Biochemical journal 2008;415(1):21-5.
2008: C B Knobbe; V Lapin; Akira Suzuki; Tak W Mak
The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey.
Oncogene 2008;27(41):5398-415.
2008: Diana Choi; Kinh-Tung T Nguyen; Linyuan Wang; Stephanie A Schroer; Akira Suzuki; Tak W Mak; Minna Woo
Partial deletion of Pten in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone.
Endocrinology 2008;149(9):4382-6.
2008: Nien-Jung Chen; Iok In Christine Chio; Wen Jye Lin; Gordon Duncan; Hien Chau; David Katz; Huey-Lan Huang; Kelly A Pike; Zhenyue Hao; Yu-Wen Su; Kazuo Yamamoto; Renée F de Pooter; Juan Carlos Zúñiga-Pflücker; Andrew Wakeham; Wen-Chen Yeh; Tak W Mak
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12429-34.
2008: Matthias Lechmann; Naomi Shuman; Andrew Wakeham; Tak W Mak
The CD83 reporter mouse elucidates the activity of the CD83 promoter in B, T, and dendritic cell populations in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11887-92.
2008: Maxim V. Berezovski; Matthias Lechmann; Michael Musheev; Tak W Mak; Sergey Krylov
Aptamer-facilitated biomarker discovery (AptaBiD).
Journal of the American Chemical Society 2008;130(28):9137-43.
2008: Yong-Ling P Ow; Douglas R Green; Zhenyue Hao; Tak W Mak
Cytochrome c: functions beyond respiration.
Nature reviews. Molecular cell biology 2008;9(7):532-42.
2008: Enrico Arpaia; Tak W Mak
Micromanagement of lymphomas.
PLoS biology 2008;6(6):e156.
2008: richard tomasini; Tak W Mak; Gerry Melino
The impact of p53 and p73 on aneuploidy and cancer.
Trends in cell biology 2008;18(5):244-52.
2008: Shoko Kuroda; Miki Nishio; Takehiko Sasaki; Yasuo Horie; Koichi Kawahara; Masato Sasaki; Miyuki Natsui; Takashi Matozaki; Hiroyuki Tezuka; Toshiaki Ohteki; Irmgard Förster; Tak W Mak; Toru Nakano; Akira Suzuki
Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages.
European journal of immunology 2008;38(5):1331-40.
2008: Almut Dufner; Gordon S Duncan; Andrew Wakeham; Alisha R Elford; Håkan T Hall; Pamela S Ohashi; Tak W Mak
CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.
Molecular and cellular biology 2008;28(5):1541-52.
2008: Thomas Calzascia; Marc Pellegrini; Albert Lin; Kristine M Garza; Alisha R Elford; Arda Shahinian; Pamela S Ohashi; Tak W Mak
CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2999-3004.
2008: Brooke M Emerling; Frank Weinberg; Juinn-Lin Liu; Tak W Mak; Navdeep S Chandel
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2622-7.
2008: Ling Xue; Hector Nolla; Akira Suzuki; Tak W Mak; Astar Winoto
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):2022-7.
2008: Håkan T L Hall; Margareta T Wilhelm; Samuel D Saibil; Tak W Mak; Richard A Flavell; Pamela S Ohashi
RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses.
European journal of immunology 2008;38(1):64-72.
2007: Walbert J Bakker; Isaac S Harris; Tak W Mak
FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2.
Molecular cell 2007;28(6):941-53.
2007: Amy Erica Lin; Tak W Mak
The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells.
Current opinion in immunology 2007;19(6):665-73.
2007: Thomas Calzascia; Marc Pellegrini; Håkan Hall; Laurent Sabbagh; Nobuyuki Ono; Alisha R Elford; Tak W Mak; Pamela S Ohashi
TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice.
The Journal of clinical investigation 2007;117(12):3833-45.
2007: Hossein Aleyasin; Maxime W C Rousseaux; Maryam Phillips; Raymond H Kim; Ross J Bland; Steven M Callaghan; ruth slack; Matthew J During; Tak W Mak; Rousseaux Maxime
The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18748-53.
2007: Tak W Mak
The T cell antigen receptor: "The Hunting of the Snark".
European journal of immunology 2007;37 Suppl 1():S83-93.
2007: Anne Brüstle; Sylvia Heink; Magdalena Huber; Christine Rosenplänter; Christine Stadelmann; Philipp Yu; Enrico Arpaia; Tak W Mak; Thomas Kamradt; Michael Lohoff
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4.
Nature immunology 2007;8(9):958-66.
2007: Andrew T Ho; Qin H Li; Hitoshi Okada; Tak W Mak; Eldad Zacksenhaus
XIAP activity dictates Apaf-1 dependency for caspase 9 activation.
Molecular and cellular biology 2007;27(16):5673-85.
2007: Walbert J Bakker; Thamar B van Dijk; Martine Parren-van Amelsvoort; Andrea Kolbus; Kazuo Yamamoto; Peter Steinlein; Roel G W Verhaak; Tak W Mak; Hartmut Beug; Bob Löwenberg; Marieke von Lindern
Differential regulation of Foxo3a target genes in erythropoiesis.
Molecular and cellular biology 2007;27(10):3839-3854.
2007: James G Pan; Tak W Mak
Metabolic targeting as an anticancer strategy: dawn of a new era?
Science's STKE : signal transduction knowledge environment 2007;2007(381):pe14.
2007: Toru Sasaki; Eugene C Gan; Andrew Wakeham; Sally Kornbluth; Tak W Mak; Hitoshi Okada
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
Genes & development 2007;21(7):848-61.
2007: Daniel Rueda; Olivier Gaide; Liza Ho; Elodie Lewkowicz; Florence Niedergang; Stephan Hailfinger; Fabien Rebeaud; Montserrat Guzzardi; Béatrice Conne; Marcus Thelen; Jérôme Delon; Uta Ferch; Tak W Mak; Jürgen Ruland; Juerg Schwaller; Margot Thome
Bcl10 controls TCR- and FcgammaR-induced actin polymerization.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4373-84.
2007: Akira Suzuki; Koichi Hamada; Takehiko Sasaki; Tak W Mak; Toru Nakano
Role of PTEN/PI3K pathway in endothelial cells.
Biochemical Society transactions 2007;35(Pt 2):172-6.
2007: Kathrin Zaugg; Yu-Wen Su; Patrick T Reilly; Yasmin Moolani; Carol C Cheung; Raza Hakem; Atsushi Hirao; Qinghua Liu; Stephen J Elledge; Tak W Mak
Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3805-10.
2007: Gloria I Perez; Beth M Acton; Andrea Jurisicova; Guy Perkins; A White; J Brown; Alexander M Trbovich; Mee-Ran Kim; R Fissore; J Xu; A Ahmady; S G D'Estaing; H Li; Wataru Kagawa; Hitoshi Kurumizaka; Shigeyuki Yokoyama; H Okada; Tak W Mak; M H Ellisman; Robert Casper; Jonathan L Tilly
Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure.
Cell death and differentiation 2007;14(3):524-33.
2007: Hideyuki Yanai; Hui-Min Chen; Takayuki Inuzuka; Seiji Kondo; Tak W Mak; Akinori Takaoka; Kenya Honda; Tadatsugu Taniguchi
Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3402-7.
2007: Philipp J Jost; Stephanie Weiss; Uta Ferch; Olaf Gross; Tak W Mak; Christian Peschel; Jürgen Ruland
Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):953-60.
2007: Linda M McAllister-Lucas; Jürgen Ruland; Katy Siu; Xiaohong Jin; Shufang Gu; David S L Kim; Peter Kuffa; Dawn Kohrt; Tak W Mak; Gabriel Nuñez; Peter C Lucas
CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):139-44.
2007: Stefanie Klemm; Stephanie Zimmermann; Christian Peschel; Tak W Mak; Jürgen Ruland
Bcl10 and Malt1 control lysophosphatidic acid-induced NF-kappaB activation and cytokine production.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):134-8.
2007: Keisuke Ito; Keiyo Takubo; Fumio Arai; Hitoshi Satoh; Sahoko Matsuoka; Masako Ohmura; Kazuhito Naka; Masaki Azuma; Kana Miyamoto; Kentaro Hosokawa; Yasuo Ikeda; Tak W Mak; Toshio Suda; Atsushi Hirao
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):103-10.
2007: Miki Nishio; Ken-ichi Watanabe; Junko Sasaki; Choji Taya; Shunsuke Takasuga; Ryota Iizuka; Tamas Balla; Masakazu Yamazaki; Hiroshi Watanabe; Reietsu Itoh; Shoko Kuroda; Yasuo Horie; Irmgard Förster; Tak W Mak; Hiromichi Yonekawa; Josef M Penninger; Yasunori Kanaho; Akira Suzuki; Takehiko Sasaki
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1.
Nature cell biology 2007;9(1):36-44.
2007: Maxim V. Berezovski; Tak W Mak; Sergey Krylov
Cell lysis inside the capillary facilitated by transverse diffusion of laminar flow profiles (TDLFP).
Analytical and bioanalytical chemistry 2007;387(1):91-6.
2006: Alison M Cheung; Tak W Mak
PTEN in the haematopoietic system and its therapeutic indications.
Trends in molecular medicine 2006;12(11):503-5.
2006: Casey M Clements; Richard S McNally; Brian J Conti; Tak W Mak; Jenny P-Y Ting
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15091-6.
2006: Woong-Kyung Suh; Seng Wang; Gordon S Duncan; Yoshiyuki Miyazaki; Elizabeth Cates; Tina Walker; Beata U Gajewska; Elissa Deenick; Wojciech Dawicki; Hitoshi Okada; Andrew Wakeham; Annick Itie; Tania H Watts; Pamela S Ohashi; Manel Jordana; Hiroki Yoshida; Tak W Mak
Generation and characterization of B7-H4/B7S1/B7x-deficient mice.
Molecular and cellular biology 2006;26(17):6403-11.
2006: Dong Zhang; Kathrin Zaugg; Tak W Mak; Stephen J Elledge
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.
Cell 2006;126(3):529-42.
2006: Han You; Marc Pellegrini; Katsuya Tsuchihara; Kazuo Yamamoto; Georg Hacker; Miriam Erlacher; Andreas Villunger; Tak W Mak
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.
The Journal of experimental medicine 2006;203(7):1657-63.
2006: Elmar Wegener; Andrea Oeckinghaus; Nikoletta Papadopoulou; Liron Lavitas; Marc Schmidt-Supprian; Uta Ferch; Tak W Mak; Jürgen Ruland; Vigo Heissmeyer; Daniel Krappmann
Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.
Molecular cell 2006;23(1):13-23.
2006: Leona Plum; Xiaosong Ma; Brigitte Hampel; Nina Balthasar; Roberto Coppari; Heike Münzberg; Marya Shanabrough; Denis Burdakov; Eva Rother; Ruth Janoschek; Jens Alber; Bengt F Belgardt; Linda Koch; Jost Seibler; Frieder Schwenk; Csaba Fekete; Akira Suzuki; Tak W Mak; Wilhelm Krone; Tamas L Horvath; Frances M Ashcroft; Jens C Brüning
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.
The Journal of clinical investigation 2006;116(7):1886-901.
2006: Kinh-Tung T Nguyen; Panteha Tajmir; Chia Hung Lin; Nicole Liadis; Xu-Dong Zhu; Mohamed Eweida; Gunce Tolasa-Karaman; Fang Cai; Rennian Wang; Tadahiro Kitamura; Denise D Belsham; Michael B Wheeler; Akira Suzuki; Tak W Mak; Minna Woo
Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo.
Molecular and cellular biology 2006;26(12):4511-8.
2006: Almut Dufner; Tak W Mak
CARD tricks: controlling the interactions of CARD6 with RICK and microtubules.
Cell cycle (Georgetown, Tex.) 2006;5(8):797-800.
2006: Raymond H Kim; Tak W Mak
Tumours and tremors: how PTEN regulation underlies both.
British journal of cancer 2006;94(5):620-4.
2006: Megan Cully; Han You; Arnold J Levine; Tak W Mak
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.
Nature reviews. Cancer 2006;6(3):184-92.
2006: Stefanie Klemm; Jan Gutermuth; Lothar Hültner; Tim D. Sparwasser; Heidrun Behrendt; Christian Peschel; Tak W Mak; Thilo Jakob; Jürgen Ruland
The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation.
The Journal of experimental medicine 2006;203(2):337-47.
2006: Thorsten Berger; Atsushi Togawa; Gordon S Duncan; Andrew Elia; Annick You-Ten; Andrew Wakeham; Hannah E H Fong; Carol C Cheung; Tak W Mak
Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1834-9.
2006: Arnold J Levine; Zhaohui Feng; Tak W Mak; Han You; Shengkan Jin
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways.
Genes & development 2006;20(3):267-75.
2006: Almut Dufner; Scott Pownall; Tak W Mak
Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):988-93.
2006: Junya Masumoto; Kangkang Yang; Sooryanarayana Lnu; Mizuho Hasegawa; Scott A Tomlins; Su Qiu; Yukari Fujimoto; Akiko Kawasaki; Simon J Foster; Yasuo Horie; Tak W Mak; Gabriel Núñez; Arul M Chinnaiyan; Koichi Fukase; Naohiro Inohara
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo.
The Journal of experimental medicine 2006;203(1):203-13.
2006: David S Smookler; Fazilat F Mohammed; Zamaneh Kassiri; Gordon S Duncan; Tak W Mak; Rama Khokha
Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):721-5.
2006: Eric White; Rachelle G Atrasz; Biao Hu; Sem H Phan; Vuk Stambolic; Tak W Mak; Cory M Hogaboam; Kevin R Flaherty; Fernando J Martinez; Christopher D Kontos; Galen Toews
Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10).
American journal of respiratory and critical care medicine 2006;173(1):112-21.
2005: Mariana Vidric; Woong-Kyung Suh; Umberto Dianzani; Tak W Mak; Tania H Watts
Cooperation between 4-1BB and ICOS in the immune response to influenza virus revealed by studies of CD28/ICOS-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7288-96.
2005: Megan Cully; Jessica Shiu; Roland P Piekorz; William J Muller; Susan J Done; Tak W Mak
Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis.
Cancer research 2005;65(22):10363-70.
2005: Masataka Asagiri; kojiro sato; Takako Usami; Sae Ochi; Hiroshi Nishina; Hiroki Yoshida; Ikuo Morita; Erwin F Wagner; Tak W Mak; Edgar Serfling; Hiroshi Takayanagi
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.
The Journal of experimental medicine 2005;202(9):1261-9.
2005: Clare C Davies; Tak W Mak; Lawrence S Young; Aristides G Eliopoulos
TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells.
Molecular and cellular biology 2005;25(22):9806-19.
2005: Christina Berube; Lorrie Boucher; Weili Ma; Andrew Wakeham; Leonardo Salmena; Raza Hakem; Wen-Chen Yeh; Tak W Mak; Samuel Benchimol
Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14314-20.
2005: Thomas G Diacovo; Amanda L Blasius; Tak W Mak; Marina Cella; Marco COLONna
Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes.
The Journal of experimental medicine 2005;202(5):687-96.
2005: Anne Hakem; Otto Sanchez-Sweatman; Annick You-Ten; Gordon Duncan; Andrew Wakeham; Rama Khokha; Tak W Mak
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis.
Genes & development 2005;19(17):1974-9.
2005: Laura Alonso; Hitoshi Okada; H Amalia Pasolli; Andrew Wakeham; Annick You-Ten; Tak W Mak; Elaine Fuchs
Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle.
The Journal of cell biology 2005;170(4):559-70.
2005: Hien Chau; Veronica Wong; Nien-Jung Chen; Huey-Lan Huang; Wen Jye Lin; Christine Mirtsos; Alisha R Elford; Madeleine Bonnard; Andrew Wakeham; Annick You-Ten; Bénédicte Lemmers; Leonardo Salmena; Marc Pellegrini; Raza Hakem; Tak W Mak; Pamela S Ohashi; Wen-Chen Yeh
Cellular FLICE-inhibitory protein is required for T cell survival and cycling.
The Journal of experimental medicine 2005;202(3):405-13.
2005: Zhenyue Hao; Gordon S Duncan; Chia-Che Chang; Andrew Elia; Min Fang; Andrew Wakeham; Hitoshi Okada; Thomas Calzascia; YingJu Jang; Annick You-Ten; Wen-Chen Yeh; Pamela S Ohashi; Xiaodong Wang; Tak W Mak
Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis.
Cell 2005;121(4):579-91.
2005: Elena Priceputu; Isabelle Rodrigue; Pavel Chrobak; Johanne Poudrier; Tak W Mak; Zaher Hanna; Chunyan Hu; Denis George Kay; Paul Jolicoeur
The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1beta-converting enzyme-deficient or Bcl2-expressing transgenic mice.
Journal of virology 2005;79(10):6377-91.
2005: Patricia A Taylor; Angela Panoskaltsis-Mortari; Gordon J Freeman; Arlene H Sharpe; Randolph J Noelle; Alexander Y Rudensky; Tak W Mak; Jonathan S Serody; Bruce R Blazar
Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).
Blood 2005;105(8):3372-80.
2005: Raymond H Kim; Patrice D Smith; Hossein Aleyasin; Shawn Hayley; Matthew P Mount; Scott Pownall; Andrew Wakeham; Annick J You-Ten; Suneil K Kalia; Patrick Horne; David Westaway; Andres M Lozano; Hymie Anisman; David Park; Tak W Mak
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):5215-20.
2005: Akinori Takaoka; Hideyuki Yanai; Seiji Kondo; Gordon Duncan; Hideo Negishi; Tatsuaki Mizutani; Shin-Ichi Kano; Kenya Honda; Yusuke Ohba; Tak W Mak; Tadatsugu Taniguchi
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.
Nature 2005;434(7030):243-9.
2005: Raymond H Kim; Malte Peters; YingJu Jang; Wei Shi; Melania Pintilie; Graham C Fletcher; Carmela DeLuca; Jennifer Liepa; Lily Zhou; Bryan E Snow; Richard C Binari; Armen S Manoukian; Mark R Bray; Fei-Fei Liu; Ming Tsao; Tak W Mak
DJ-1, a novel regulator of the tumor suppressor PTEN.
Cancer cell 2005;7(3):263-73.
2005: Beata U Gajewska; Anna Tafuri; Filip K Swirski; Tina Walker; Jill R Johnson; Theresa Shea; Arda Shahinian; Susanna Goncharova; Tak W Mak; Martin R Stämpfli; Manel Jordana
B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):3000-5.
2005: Michael Lohoff; Tak W Mak
Roles of interferon-regulatory factors in T-helper-cell differentiation.
Nature reviews. Immunology 2005;5(2):125-35.
2005: Nadeeja Wijesekara; Daniel Konrad; Mohamed Eweida; Craig Jefferies; Nicole Liadis; Adria Giacca; Michael A Crackower; Akira Suzuki; Tak W Mak; C Ronald Kahn; Amira Klip; Minna Woo
Muscle-specific Pten deletion protects against insulin resistance and diabetes.
Molecular and cellular biology 2005;25(3):1135-45.
2005: Eric White; Rachelle G Atrasz; Emily G Dickie; David M Aronoff; Vuk Stambolic; Tak W Mak; Bethany B Moore; Marc Peters-Golden
Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity.
American journal of respiratory cell and molecular biology 2005;32(2):135-41.
2005: Han You; Tak W Mak
Crosstalk between p53 and FOXO transcription factors.
Cell cycle (Georgetown, Tex.) 2005;4(1):37-8.
2004: Megan Cully; Andrew Elia; Siew-Hwa Ong; Vuk Stambolic; Tony Pawson; Ming Tsao; Tak W Mak
grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15358-63.
2004: Keisuke Ito; Atsushi Hirao; Fumio Arai; Sahoko Matsuoka; Keiyo Takubo; Isao Hamaguchi; Kana Nomiyama; Kentaro Hosokawa; Kazuhiro Sakurada; Naomi Nakagata; Yasuo Ikeda; Tak W Mak; Toshio Suda
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.
Nature 2004;431(7011):997-1002.
2004: Han You; YingJu Jang; Annick You-Ten; Hitoshi Okada; Jennifer Liepa; Andrew Wakeham; Kathrin Zaugg; Tak W Mak
p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):14057-62.
2004: Takashi Sakai; Li Liu; Xichuan Teng; Rika Mukai-Sakai; Hidenori Shimada; Ryuji Kaji; Tasuku Mitani; Mitsuru Matsumoto; Kazunori Toida; Kazunori Ishimura; Yuji Shishido; Tak W Mak; Kiyoshi Fukui
Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis.
The Journal of biological chemistry 2004;279(39):41131-40.
2004: Dong-Hyung Cho; Yeon-Mi Hong; Ho-June Lee; Ha-Na Woo; Jong-Ok Pyo; Tak W Mak; Yong-Keun Jung
Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein.
The Journal of biological chemistry 2004;279(38):39942-50.
2004: Per Alstergren; Baoqian Zhu; Glogauer Michael; Michael Glougauer; Tak W Mak; Richard P Ellen; Jaro Sodek
Polarization and directed migration of murine neutrophils is dependent on cell surface expression of CD44.
Cellular immunology 2004;231(1-2):146-57.
2004: Bruce R Blazar; Robert B Levy; Tak W Mak; Angela Panoskaltsis-Mortari; Hiromi Muta; Monica Jones; Melinda Roskos; Jonathan S Serody; Hideo Yagita; Eckhard R Podack; Patricia A Taylor
CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):2933-41.
2004: Woong-Kyung Suh; S X Wang; Andrew Jheon; L Moreno; Steven K Yoshinaga; Bernhard Ganss; Jaro Sodek; Marc D Grynpas; Tak W Mak
The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):12969-73.
2004: Hitoshi Okada; Tak W Mak
Pathways of apoptotic and non-apoptotic death in tumour cells.
Nature reviews. Cancer 2004;4(8):592-603.
2004: Michael Lohoff; Hans-Willi Mittrücker; Anne Brüstle; Frank Sommer; Bärbel Casper; Magda Huber; David A Ferrick; Gordon S Duncan; Tak W Mak
Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells.
The Journal of experimental medicine 2004;200(2):247-53.
2004: John Peter McPherson; Bénédicte Lemmers; Atsushi Hirao; Anne Hakem; Jacinth Abraham; Eva Migon; Elzbieta Matysiak-Zablocki; Laura Tamblyn; Otto Sanchez-Sweatman; Rama Khokha; Jeremy Squire; M Prakash Hande; Tak W Mak; Raza Hakem
Collaboration of Brca1 and Chk2 in tumorigenesis.
Genes & development 2004;18(10):1144-53.
2004: Woong-Kyung Suh; Anna Tafuri; Nancy N Berg-Brown; Arda Shahinian; Suzanne Plyte; Gordon S Duncan; Hitoshi Okada; Andrew Wakeham; Bernhard Odermatt; Pamela S Ohashi; Tak W Mak
The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5917-23.
2004: Young Trieu; Xiao-Yan Wen; Brian F Skinnider; Mark R Bray; Zhihua Li; Jaime O Claudio; Esther Masih-Khan; Yuan Xiao Zhu; Suzanne Trudel; J Andrea McCart; Tak W Mak; A Keith Stewart
Soluble interleukin-13Ralpha2 decoy receptor inhibits Hodgkin's lymphoma growth in vitro and in vivo.
Cancer research 2004;64(9):3271-5.
2004: Xiaoduan Weng; Elena Priceputu; Pavel Chrobak; Johanne Poudrier; Denis George Kay; Zaher Hanna; Tak W Mak; Paul Jolicoeur
CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease.
Journal of virology 2004;78(10):5244-57.
2004: Akira Suzuki; Takehiko Sasaki; Tak W Mak; Toru Nakano
Functional analysis of the tumour suppressor gene PTEN in murine B cells and keratinocytes.
Biochemical Society transactions 2004;32(Pt 2):362-5.
2004: Alison M Y Cheung; Andrew Elia; Ming Tsao; Susan J Done; Kay-Uwe Wagner; Lothar Hennighausen; Raza Hakem; Tak W Mak
Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.
Cancer research 2004;64(6):1959-65.
2004: Atsushi Yamanaka; Shinjiro Hamano; Yoshiyuki Miyazaki; Kazunari Ishii; Atsunobu Takeda; Tak W Mak; Kunisuke Himeno; Akihiko Yoshimura; Hiroki Yoshida
Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3590-6.
2004: Zhengfan Jiang; Tak W Mak; Ganes Sen; Xiaoxia Li
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3533-8.
2004: Stéphanie A Backman; Danny Ghazarian; Kelvin So; Otto Sanchez; Kay-Uwe Wagner; Lothar Hennighausen; Akira Suzuki; Ming Tsao; William B Chapman; Vuk Stambolic; Tak W Mak
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(6):1725-30.
2004: Hitoshi Okada; Christopher Bakal; Arda Shahinian; Andrew Elia; Andrew Wakeham; Woong-Kyung Suh; Gordon S Duncan; Maria Ciofani; Robert Rottapel; Juan Carlos Zúñiga-Pflücker; Tak W Mak
Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death.
The Journal of experimental medicine 2004;199(3):399-410.
2004: Andrew T Ho; Qin H Li; Raza Hakem; Tak W Mak; Eldad Zacksenhaus
Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific.
The EMBO journal 2004;23(2):460-72.
2004: Gen Nishitai; Nao Shimizu; Takahiro Negishi; Hiroyuki Kishimoto; Kentaro Nakagawa; Daiju Kitagawa; Tomomi Watanabe; Haruka Momose; Shinya Ohata; Shuhei Tanemura; Satoshi Asaka; Junko Kubota; Ryota Saito; Hiroki Yoshida; Tak W Mak; Teiji Wada; Josef M Penninger; Noriyuki Azuma; Hiroshi Nishina; Toshiaki Katada
Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells.
The Journal of biological chemistry 2004;279(3):1621-6.
2004: Mehrdad Hariri; Geoffrey A Wood; Marco A DiGrappa; Michelle MacPherson; Stephanie A Backman; Martin J Yaffe; Tak W Mak; Norman F Boyd; Rama Khokha
Experimental manipulation of radiographic density in mouse mammary gland.
Breast cancer research : BCR 2004;6(5):R540-5.
2003: Paul Jolicoeur; Chunyan Hu; Tak W Mak; Jean-Claude Martinou; Denis George Kay
Protection against murine leukemia virus-induced spongiform myeloencephalopathy in mice overexpressing Bcl-2 but not in mice deficient for interleukin-6, inducible nitric oxide synthetase, ICE, Fas, Fas ligand, or TNF-R1 genes.
Journal of virology 2003;77(24):13161-70.
2003: Jürgen Ruland; Gordon S Duncan; Andrew Wakeham; Tak W Mak
Differential requirement for Malt1 in T and B cell antigen receptor signaling.
Immunity 2003;19(5):749-58.
2003: Shinjiro Hamano; Kunisuke Himeno; Yoshiyuki Miyazaki; Kazunari Ishii; Atsushi Yamanaka; Atsunobu Takeda; Manxin Zhang; Hajime Hisaeda; Tak W Mak; Akihiko Yoshimura; Hiroki Yoshida
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production.
Immunity 2003;19(5):657-67.
2003: Yoshifumi Tada; Syuichi Koarada; Fumitaka Morito; Osamu Ushiyama; Yoshio Haruta; Futoshi Kanegae; Akihide Ohta; Alexandra Ho; Tak W Mak; Kohei Nagasawa
Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1.
Arthritis and rheumatism 2003;48(11):3280-90.
2003: Minna Woo; Raza Hakem; Caren Furlonger; Anne Hakem; Gordon S Duncan; Takehiko Sasaki; Denis Bouchard; Liwei Lu; Gillian E Wu; Christopher J Paige; Tak W Mak
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.
Nature immunology 2003;4(10):1016-22.
2003: Elizabeth Keramaris; Atsushi Hirao; ruth slack; Tak W Mak; David Park
Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.
The Journal of biological chemistry 2003;278(39):37782-9.
2003: Woong-Kyung Suh; Beata U Gajewska; Hitoshi Okada; Matthew A Gronski; Edward M Bertram; Wojciech Dawicki; Gordon S Duncan; Jacob Bukczynski; Suzanne Plyte; Andrew Elia; Andrew Wakeham; Annick Itie; Stephen Chung; Joan Da Costa; Sudha Arya; Tom Horan; Pauline Campbell; Kevin Gaida; Pamela S Ohashi; Tania H Watts; Steven K Yoshinaga; Mark R Bray; Manel Jordana; Tak W Mak
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.
Nature immunology 2003;4(9):899-906.
2003: Tak W Mak; Arda Shahinian; Steven K Yoshinaga; Andrew Wakeham; Lorrie Boucher; Melania Pintilie; Gordon Duncan; Beata U Gajewska; Matthew A Gronski; Urs Eriksson; Bernhard Odermatt; Alexandra Ho; Denis Bouchard; John S Whorisky; Manel Jordana; Pamela S Ohashi; Tony Pawson; Friedhelm Bladt; Anna Tafuri
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses.
Nature immunology 2003;4(8):765-72.
2003: Shinobu Suzuki; Nobutaka Suzuki; Christine Mirtsos; Thomas Horacek; Elizabeth Lye; Seo-Kyu Noh; Alexandra Ho; Denis Bouchard; Tak W Mak; Wen-Chen Yeh
Nur77 as a survival factor in tumor necrosis factor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8276-80.
2003: Mathias Chamaillard; Masahito Hashimoto; Yasuo Horie; Junya Masumoto; Su Qiu; Lisa Saab; Yasunori Ogura; Akiko Kawasaki; Koichi Fukase; Shoichi Kusumoto; Miguel A Valvano; Simon J Foster; Tak W Mak; Gabriel Nuñez; Naohiro Inohara
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.
Nature immunology 2003;4(7):702-7.
2003: Tak W Mak
'Order from disorder sprung': recognition and regulation in the immune system.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2003;361(1807):1235-50.
2003: Jürgen Ruland; Tak W Mak
From antigen to activation: specific signal transduction pathways linking antigen receptors to NF-kappaB.
Seminars in immunology 2003;15(3):177-83.
2003: Jürgen Ruland; Tak W Mak
Transducing signals from antigen receptors to nuclear factor kappaB.
Immunological reviews 2003;193():93-100.
2003: Hidetoshi Takada; Nien-Jung Chen; Christine Mirtsos; Shinobu Suzuki; Nobutaka Suzuki; Andrew Wakeham; Tak W Mak; Wen-Chen Yeh
Role of SODD in regulation of tumor necrosis factor responses.
Molecular and cellular biology 2003;23(11):4026-33.
2003: Atsunobu Takeda; Shinjiro Hamano; Atsushi Yamanaka; Toshikatsu Hanada; Tatsuro Ishibashi; Tak W Mak; Akihiko Yoshimura; Hiroki Yoshida
Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):4886-90.
2003: Tohru Kimura; Akira Suzuki; Yukiko Fujita; Kentaro Yomogida; Hilda Lomeli; Noriko Asada; Megumi Ikeuchi; Andras Nagy; Tak W Mak; Toru Nakano
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production.
Development (Cambridge, England) 2003;130(8):1691-700.
2003: Rachel Sarig; Yehudit Zaltsman; Richard C Marcellus; Richard Flavell; Tak W Mak; Atan Gross
BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts.
The Journal of biological chemistry 2003;278(12):10707-15.
2003: Shinyop Kim; Ross N A La Motte-Mohs; Dorothea Rudolph; Juan Carlos Zuniga-Pflucker; Tak W Mak
The role of nuclear factor-kappaB essential modulator (NEMO) in B cell development and survival.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1203-8.
2002: Hiroshi Takayanagi; Sunhwa Kim; Takako Koga; Hiroshi Nishina; Masashi Isshiki; Hiroki Yoshida; Akio Saiura; Miho Isobe; Taeko Yokochi; Jun-Ichiro Inoue; Erwin F Wagner; Tak W Mak; Tatsuhiko Kodama; Tadatsugu Taniguchi
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.
Developmental cell 2002;3(6):889-901.
2002: Edward M Bertram; Anna Tafuri; Arda Shahinian; Vera S F Chan; Lukas Hunziker; Mike Recher; Pamela S Ohashi; Tak W Mak; Tania H Watts
Role of ICOS versus CD28 in antiviral immunity.
European journal of immunology 2002;32(12):3376-85.
2002: Vishva Dixit; Tak W Mak
NF-kappaB signaling. Many roads lead to madrid.
Cell 2002;111(5):615-9.
2002: Stephan Ensminger; Bernd M Spriewald; Ulrich Steger; Peter J Morris; Tak W Mak; Kathryn J Wood
Platelet-endothelial cell adhesion molecule-1 (CD31) expression on donor endothelial cells attenuates the development of transplant arteriosclerosis.
Transplantation 2002;74(9):1267-73.
2002: Alison M Y Cheung; M Prakash Hande; Farid Jalali; Ming Tsao; Brian F Skinnider; Atsushi Hirao; John Peter McPherson; Jana Karaskova; Akira Suzuki; Andrew Wakeham; Annick You-Ten; Andrew Elia; Jeremy Squire; Robert Bristow; Raza Hakem; Tak W Mak
Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.
Cancer research 2002;62(21):6194-204.
2002: Tomomi Watanabe; Kentaro Nakagawa; Shinya Ohata; Daiju Kitagawa; Gen Nishitai; Jungwon Seo; Shuhei Tanemura; Nao Shimizu; Hiroyuki Kishimoto; Teiji Wada; Junken Aoki; Hiroyuki Arai; Takeshi Iwatsubo; Miyuki Mochita; Toshio Watanabe; Masanobu Satake; Yoshiaki Ito; Toshifumi Matsuyama; Tak W Mak; Josef M Penninger; Hiroshi Nishina; Toshiaki Katada
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.
Developmental biology 2002;250(2):332-47.
2002: Michael Lohoff; Hans-Willi Mittrücker; Stefan Prechtl; Susi Bischof; Frank Sommer; Sonja Kock; David A Ferrick; Gordon S Duncan; André Gessner; Tak W Mak
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11808-12.
2002: Atsushi Hirao; Alison Cheung; Gordon Duncan; Pierre-Marie Girard; Andrew Elia; Andrew Wakeham; Hitoshi Okada; Talin Sarkissian; Jorge A Wong; Takashi Sakai; Elisa de Stanchina; Robert G Bristow; Toshio Suda; Scott W Lowe; Penny A Jeggo; Stephen J Elledge; Tak W Mak
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Molecular and cellular biology 2002;22(18):6521-32.
2002: Akihiro Muto; Jürgen Ruland; Linda M McAllister-Lucas; Peter C Lucas; Shoji Yamaoka; Felicia F Chen; Amy Lin; Tak W Mak; Gabriel Núñez; Naohiro Inohara
Protein kinase C-associated kinase (PKK) mediates Bcl10-independent NF-kappa B activation induced by phorbol ester.
The Journal of biological chemistry 2002;277(35):31871-6.
2002: Tak W Mak; Wen-Chen Yeh
Immunology: a block at the toll gate.
Nature 2002;418(6900):835-6.
2002: Malte Peters; Carmela DeLuca; Atsushi Hirao; Vuk Stambolic; Julia Potter; Lily Zhou; Jennifer Liepa; Bryan E Snow; Sudha Arya; Jorge Wong; Denis Bouchard; Richard C Binari; Armen S Manoukian; Tak W Mak
Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11305-10.
2002: Melissa T Jack; Richard A Woo; Atsushi Hirao; Alison Cheung; Tak W Mak; Patrick W K Lee
Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9825-9.
2002: Brian F Skinnider; Tak W Mak
The role of cytokines in classical Hodgkin lymphoma.
Blood 2002;99(12):4283-97.
2002: Brian F Skinnider; Ursula Kapp; Tak W Mak
The role of interleukin 13 in classical Hodgkin lymphoma.
Leukemia & lymphoma 2002;43(6):1203-10.
2002: Hitoshi Okada; Woong-Kyung Suh; Jianping Jin; Minna Woo; Chunying Du; Andrew Elia; Gordon S Duncan; Andrew Wakeham; Annick Itie; Scott W Lowe; Xiaodong Wang; Tak W Mak
Generation and characterization of Smac/DIABLO-deficient mice.
Molecular and cellular biology 2002;22(10):3509-17.
2002: Nobutaka Suzuki; Shinobu Suzuki; Gordon S Duncan; Douglas G Millar; Teiji Wada; Christine Mirtsos; Hidetoshi Takada; Andrew Wakeham; Annick Itie; Shyun Li; Josef M Penninger; Holger Wesche; Pamela S Ohashi; Tak W Mak; Wen-Chen Yeh
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.
Nature 2002;416(6882):750-6.
2002: Georg F Weber; Roderick T Bronson; John Ilagan; Harvey Cantor; Rudolf Schmits; Tak W Mak
Absence of the CD44 gene prevents sarcoma metastasis.
Cancer research 2002;62(8):2281-6.
2002: Damu Tang; Dongcheng Wu; Atsushi Hirao; Jill Lahti; Lieqi Liu; Brie Mazza; Vincent J Kidd; Tak W Mak; Alistair J Ingram
ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.
The Journal of biological chemistry 2002;277(15):12710-7.
2002: Seiji Hitoshi; Tania O Alexson; Vincent Tropepe; Dorit B Donoviel; Andrew Elia; Jeffrey S Nye; Ronald A Conlon; Tak W Mak; alan bernstein; Derek van der Kooy
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.
Genes & development 2002;16(7):846-58.
2002: Hiromitsu Hara; Atsunobu Takeda; Michiyo Takeuchi; Andrew Wakeham; Annick Itié; Masafumi Sasaki; Tak W Mak; Akihiko Yoshimura; Kikuo Nomoto; Hiroki Yoshida
The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2288-95.
2002: Brian F Skinnider; Andrew Elia; Randy D Gascoyne; Bruce Patterson; Lorenz Trumper; Ursula Kapp; Tak W Mak
Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.
Blood 2002;99(2):618-26.
2002: Tak W Mak; Wen-Chen Yeh
Signaling for survival and apoptosis in the immune system.
Arthritis research 2002;4 Suppl 3():S243-52.
2001: Brian F Skinnider; Ursula Kapp; Tak W Mak
Interleukin 13: a growth factor in hodgkin lymphoma.
International archives of allergy and immunology 2001;126(4):267-76.
2001: Stéphanie A Backman; Vuk Stambolic; Akira Suzuki; James S J Haight; Andrew Elia; Jim Pretorius; Ming Tsao; Patrick Shannon; Brad Bolon; Gwen O Ivy; Tak W Mak
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.
Nature genetics 2001;29(4):396-403.
2001: Takehiko Sasaki; T Wada; Hiroyuki Kishimoto; Junko Irie-Sasaki; Goichi Matsumoto; T Goto; Z Yao; Andrew Wakeham; Tak W Mak; A Suzuki; S K Cho; J C Zuniga-Pflucker; Antonio J Oliveira-dos-Santos; T Katada; Hiroshi Nishina; Josef M Penninger
The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.
The Journal of experimental medicine 2001;194(6):757-68.
2001: Kevin J Leco; P Waterhouse; Otto H Sanchez; K L Gowing; A R Poole; A Wakeham; Tak W Mak; Rama Khokha
Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3).
The Journal of clinical investigation 2001;108(6):817-29.
2001: Linda M McAllister-Lucas; Naohiro Inohara; Peter C Lucas; Jürgen Ruland; Adalberto Benito; Quanwen Li; Shiming Chen; Felicia F Chen; Shoji Yamaoka; Inder M Verma; Tak W Mak; Gabriel Núñez
Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction.
The Journal of biological chemistry 2001;276(33):30589-97.
2001: Damu Tang; H Okada; Jürgen Ruland; Lieqi Liu; Vuk Stambolic; Tak W Mak; Alistair J Ingram
Akt is activated in response to an apoptotic signal.
The Journal of biological chemistry 2001;276(32):30461-6.
2001: Aaron D Schimmer; David W Hedley; Sue Chow; Nhu-An Pham; Avijit Chakrabartty; D Bouchard; Tak W Mak; Michael R Trus; Mark D Minden
The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2.
Cell death and differentiation 2001;8(7):725-33.
2001: K Miyazaki; Hiroki Yoshida; Masafumi Sasaki; Hiromitsu Hara; G Kimura; Tak W Mak; Kikuo Nomoto
Caspase-independent cell death and mitochondrial disruptions observed in the Apaf1-deficient cells.
Journal of biochemistry 2001;129(6):963-9.
2001: Akira Suzuki; M T Yamaguchi; Toshiaki Ohteki; T Sasaki; Tsuneyasu Kaisho; Y Kimura; R Yoshida; Andrew Wakeham; T Higuchi; M Fukumoto; T Tsubata; P S Ohashi; Shigeo Koyasu; J M Penninger; Toru Nakano; Tak W Mak
T cell-specific loss of Pten leads to defects in central and peripheral tolerance.
Immunity 2001;14(5):523-34.
2001: Vincent Tropepe; Seiji Hitoshi; C Sirard; Tak W Mak; Janet Rossant; Derek van der Kooy
Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism.
Neuron 2001;30(1):65-78.
2001: Klaus Okkenhaug; Linda Wu; K M Garza; Jose La Rose; W Khoo; Bernhard Odermatt; Tak W Mak; Pamela S Ohashi; Robert Rottapel
A point mutation in CD28 distinguishes proliferative signals from survival signals.
Nature immunology 2001;2(4):325-32.
2001: Nicholas Joza; Santos A Susin; Eric Daugas; William L Stanford; S K Cho; C Y Li; Takehiko Sasaki; Andrew Elia; Hai-Ying M Cheng; Luigi Ravagnan; Karine F Ferri; Naoufal Zamzami; Andrew Wakeham; Raza Hakem; H Yoshida; Young-Yun Kong; Tak W Mak; J C Zúñiga-Pflücker; Guido Kroemer; Josef M Penninger
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death.
Nature 2001;410(6828):549-54.
2001: Jürgen Ruland; C Sirard; Andrew Elia; D MacPherson; Andrew Wakeham; L Li; José Luis de la Pompa; S N Cohen; Tak W Mak
p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1859-64.
2001: Frank Sommer; Gerhard Faller; Martin Röllinghoff; Thomas Kirchner; Tak W Mak; Michael Lohoff
Lack of gastritis and of an adaptive immune response in interferon regulatory factor-1-deficient mice infected with Helicobacter pylori.
European journal of immunology 2001;31(2):396-402.
2001: Jürgen Ruland; Gordon S Duncan; Andrew Elia; I del Barco Barrantes; L Nguyen; Suzanne Plyte; Douglas G Millar; Denis Bouchard; Andrew Wakeham; Pamela S Ohashi; Tak W Mak
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.
Cell 2001;104(1):33-42.
2001: Anna Tafuri; Arda Shahinian; Friedhelm Bladt; Steven K Yoshinaga; Manel Jordana; Andrew Wakeham; Lorrie Boucher; Denis Bouchard; Vera S F Chan; Gordon Duncan; Bernhard Odermatt; Alexandra Ho; Annick Itie; Tom Horan; John S Whoriskey; Tony Pawson; Josef M Penninger; Pamela S Ohashi; Tak W Mak
ICOS is essential for effective T-helper-cell responses.
Nature 2001;409(6816):105-9.
2001: Brian F Skinnider; Andrew Elia; Randy D Gascoyne; L H Trümper; F von Bonin; Ursula Kapp; Bruce Patterson; B E Snow; Tak W Mak
Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.
Blood 2001;97(1):250-5.
2000: B Wang; H Fujisawa; L Zhuang; Irwin Freed; Brandon G Howell; S Shahid; GM Shivji; Tak W Mak; Daniel N Sauder
CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6783-90.
2000: Minna Woo; Raza Hakem; Tak W Mak
Executionary pathway for apoptosis: lessons from mutant mice.
Cell research 2000;10(4):267-78.
2000: G Boehmelt; Andrew Wakeham; Andrew Elia; Takehiko Sasaki; Suzanne Plyte; J Potter; Y Yang; E Tsang; Jürgen Ruland; Norman N Iscove; James W Dennis; Tak W Mak
Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells.
The EMBO journal 2000;19(19):5092-104.
2000: Mark A Lomaga; Dr. Jeffrey Henderson; Andrew Elia; J Robertson; R S Noyce; Wen-Chen Yeh; Tak W Mak
Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(19):7384-93.
2000: Madeleine Bonnard; Christine Mirtsos; Shinobu Suzuki; K Graham; J Huang; M Ng; A Itié; Andrew Wakeham; Arda Shahinian; WJ Henzel; Andrew Elia; W Shillinglaw; Tak W Mak; Z Cao; Wen-Chen Yeh
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.
The EMBO journal 2000;19(18):4976-85.
2000: Takehiko Sasaki; Junko Irie-Sasaki; Y Horie; Kurt Bachmaier; Jimmie E Fata; M Li; Akira Suzuki; Denis Bouchard; Alexandra Ho; Mark Redston; Steven Gallinger; Rama Khokha; Tak W Mak; Phillip T Hawkins; Len Stephens; Stephen W Scherer; May Tsao; Josef M Penninger
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.
Nature 2000;406(6798):897-902.
2000: Santos A Susin; Eric Daugas; Luigi Ravagnan; K Samejima; Naoufal Zamzami; M Loeffler; P Costantini; Karine F Ferri; T Irinopoulou; Marie-Christine Prévost; Greg M Brothers; Tak W Mak; Josef M Penninger; W C Earnshaw; Guido Kroemer
Two distinct pathways leading to nuclear apoptosis.
The Journal of experimental medicine 2000;192(4):571-80.
2000: S E Scanga; L Ruel; Richard C Binari; Bryan E Snow; Vuk Stambolic; D Bouchard; Malte Peters; B Calvieri; Tak W Mak; James R Woodgett; Armen S Manoukian
The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila.
Oncogene 2000;19(35):3971-7.
2000: Michael Lohoff; Gordon S Duncan; David A Ferrick; Hans-Willi Mittrücker; Susi Bischof; Stefan Prechtl; Martin Röllinghoff; E Schmitt; A Pahl; Tak W Mak
Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells.
The Journal of experimental medicine 2000;192(3):325-36.
2000: Vuk Stambolic; Ming Tsao; D Macpherson; Akira Suzuki; William B Chapman; Tak W Mak
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.
Cancer research 2000;60(13):3605-11.
2000: Tak W Mak; Anne Hakem; John Peter McPherson; Amro Shehabeldin; E Zablocki; Eva Migon; Gordon S Duncan; Denis Bouchard; Andrew Wakeham; A Cheung; Jana Karaskova; Ildiko Sarosi; Jeremy Squire; Jamey D Marth; Raza Hakem
Brca1 required for T cell lineage development but not TCR loci rearrangement.
Nature immunology 2000;1(1):77-82.
2000: Wen-Chen Yeh; Annick Itie; Andrew Elia; M Ng; HB Shu; Andrew Wakeham; Christine Mirtsos; Nobutaka Suzuki; Madeleine Bonnard; David V Goeddel; Tak W Mak
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.
Immunity 2000;12(6):633-42.
2000: G Boehmelt; Irene Fialka; G Brothers; MD McGinley; Scott D Patterson; Rong Mo; Chi-Chung Hui; S Chung; Lukas A Huber; Tak W Mak; Norman N Iscove
Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association.
The Journal of biological chemistry 2000;275(17):12821-32.
2000: D Rudolph; Wen-Chen Yeh; Andrew Wakeham; B Rudolph; D Nallainathan; J Potter; Andrew Elia; Tak W Mak
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.
Genes & development 2000;14(7):854-62.
2000: Atsushi Hirao; Young-Yun Kong; S Matsuoka; Andrew Wakeham; Jürgen Ruland; H Yoshida; D Liu; Stephen J Elledge; Tak W Mak
DNA damage-induced activation of p53 by the checkpoint kinase Chk2.
Science (New York, N.Y.) 2000;287(5459):1824-7.
2000: Takehiko Sasaki; Junko Irie-Sasaki; Russell G Jones; Antonio J Oliveira-dos-Santos; William L Stanford; B Bolon; Andrew Wakeham; Annick Itie; Denis Bouchard; Ivona Kozieradzki; Nicholas Joza; Tak W Mak; Pamela S Ohashi; Akira Suzuki; Josef M Penninger
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
Science (New York, N.Y.) 2000;287(5455):1040-6.
2000: Linh T Nguyen; Kim J McKall-Faienza; Arsen Zakarian; DE Speiser; Tak W Mak; Pamela S Ohashi
TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions.
European journal of immunology 2000;30(2):683-8.
2000: C Sirard; S Kim; Christine Mirtsos; P Tadich; PA Hoodless; A Itié; R Maxson; Jeffrey L Wrana; Tak W Mak
Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.
The Journal of biological chemistry 2000;275(3):2063-70.
1999: Steven K Yoshinaga; John S Whoriskey; SD Khare; Ulla Sarmiento; Jane Guo; Tom Horan; G Shih; Ming Zhang; MA Coccia; Tadahiko Kohno; A Tafuri-Bladt; D Brankow; P Campbell; D Chang; L Chiu; T Dai; Gordon Duncan; Gary S Elliott; A Hui; S M McCabe; Sheila Scully; Arda Shahinian; Christine L Shaklee; Gwyneth Van; Tak W Mak; Giorgio Senaldi
T-cell co-stimulation through B7RP-1 and ICOS.
Nature 1999;402(6763):827-32.
1999: Giorgio Senaldi; Christine L Shaklee; Jane Guo; L Martin; Tom Boone; Tak W Mak; TR Ulich
Protection against the mortality associated with disease models mediated by TNF and IFN-gamma in mice lacking IFN regulatory factor-1.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6820-6.
1999: Vuk Stambolic; Tak W Mak; James R Woodgett
Modulation of cellular apoptotic potential: contributions to oncogenesis.
Oncogene 1999;18(45):6094-103.
1999: Minna Woo; Anne Hakem; Andrew Elia; Raza Hakem; Gordon S Duncan; B J Patterson; Tak W Mak
In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4909-16.
1999: Klaus P Hoeflich; Wen-Chen Yeh; Z Yao; Tak W Mak; James R Woodgett
Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1).
Oncogene 1999;18(42):5814-20.
1999: Linh T Nguyen; Gordon S Duncan; Christine Mirtsos; M Ng; DE Speiser; Arda Shahinian; M W Marino; Tak W Mak; Pamela S Ohashi; Wen-Chen Yeh
TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.
Immunity 1999;11(3):379-89.
1999: Martin F Bachmann; DE Speiser; Tak W Mak; Pamela S Ohashi
Absence of co-stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo.
European journal of immunology 1999;29(7):2156-66.
1999: Ursula Kapp; Wen-Chen Yeh; Bruce Patterson; Andrew Elia; D Kägi; Alexandra Ho; A Hessel; M Tipsword; A Williams; Christine Mirtsos; Annick Itie; M Moyle; Tak W Mak
Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells.
The Journal of experimental medicine 1999;189(12):1939-46.
1999: Wen-Chen Yeh; Raza Hakem; Minna Woo; Tak W Mak
Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling.
Immunological reviews 1999;169():283-302.
1999: I B Barrantes; Andrew Elia; K Wünsch; MH Hrabe de Angelis; Tak W Mak; Janet Rossant; Ronald A Conlon; Achim Gossler; José Luis de la Pompa
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse.
Current biology : CB 1999;9(9):470-80.
1999: Giorgio Senaldi; Christine L Shaklee; Tak W Mak; TR Ulich
Corynebacterium parvum- and Mycobacterium bovis Bacillus Calmette and Guerin-induced granuloma formation in mice lacking CD4 and CD8.
Cellular immunology 1999;193(2):155-61.
1999: Mark A Lomaga; Wen-Chen Yeh; Ildiko Sarosi; Gordon S Duncan; Caren Furlonger; Alexandra Ho; Sean Morony; Charles Capparelli; Gwyneth Van; Stephen Kaufman; A van der Heiden; Annick Itie; Andrew Wakeham; W Khoo; Takehiko Sasaki; Z Cao; Josef M Penninger; Christopher J Paige; David L Lacey; Colin R Dunstan; william boyle; David V Goeddel; Tak W Mak
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Genes & development 1999;13(8):1015-24.
1999: D Kägi; A Ho; Bernhard Odermatt; Arsen Zakarian; Pamela S Ohashi; Tak W Mak
TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4598-605.
1999: Antonio J Oliveira-dos-Santos; A Ho; Y Tada; JJ Lafaille; Susumu Tonegawa; Tak W Mak; Josef M Penninger
CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4490-5.
1999: Kurt Bachmaier; N Neu; Raymond S Yeung; Tak W Mak; Peter Liu; Josef M Penninger
Generation of humanized mice susceptible to peptide-induced inflammatory heart disease.
Circulation 1999;99(14):1885-91.
1999: MS Soengas; R M Alarcón; H Yoshida; A J Giaccia; Raza Hakem; Tak W Mak; Scott W Lowe
Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.
Science (New York, N.Y.) 1999;284(5411):156-9.
1999: Toshiaki Ohteki; Chikako Maki; Shigeo Koyasu; Tak W Mak; Pamela S Ohashi
Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):3753-6.
1999: Gordon S Duncan; David Andrew; H Takimoto; Stephen A Kaufman; H Yoshida; JP Spellberg; Andrew Elia; Andrew Wakeham; B Karan-Tamir; WA Muller; Giorgio Senaldi; MM Zukowski; J L de la Pompa; Tak W Mak
Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):3022-30.
1999: L Zhuang; B Wang; G A Shinder; GM Shivji; Tak W Mak; Daniel N Sauder
TNF receptor p55 plays a pivotal role in murine keratinocyte apoptosis induced by ultraviolet B irradiation.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1440-7.
1999: Young-Yun Kong; H Yoshida; Ildiko Sarosi; Hong Lin Tan; E Timms; Charles Capparelli; Sean Morony; Antonio J Oliveira-dos-Santos; Gwyneth Van; Annick Itie; W Khoo; Andrew Wakeham; Colin R Dunstan; David L Lacey; Tak W Mak; william boyle; Josef M Penninger
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.
Nature 1999;397(6717):315-23.
1999: Tak W Mak; W C Yeh
Genetic analysis of apoptotic and survival signals.
Cold Spring Harbor symposia on quantitative biology 1999;64():335-42.
1998: H Fujii; Kouetsu Ogasawara; H Otsuka; M Suzuki; K Yamamura; Taeko Yokochi; Tsuyoshi Miyazaki; Hiroshi Suzuki; Tak W Mak; Shinsuke Taki; Tadatsugu Taniguchi
Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations.
The EMBO journal 1998;17(22):6551-7.
1998: Akira Suzuki; José Luis de la Pompa; Vuk Stambolic; Andrew Elia; Takehiko Sasaki; I del Barco Barrantes; Alexandra Ho; Andrew Wakeham; Annick Itie; W Khoo; M Fukumoto; Tak W Mak
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
Current biology : CB 1998;8(21):1169-78.
1998: Vuk Stambolic; Akira Suzuki; José Luis de la Pompa; Greg M Brothers; Christine Mirtsos; Takehiko Sasaki; Jürgen Ruland; Josef M Penninger; David Siderovski; Tak W Mak
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.
Cell 1998;95(1):29-39.
1998: Raza Hakem; José Luis de la Pompa; Tak W Mak
Developmental studies of Brca1 and Brca2 knock-out mice.
Journal of mammary gland biology and neoplasia 1998;3(4):431-45.
1998: Josef M Penninger; Tak W Mak
Thymocyte selection in Vav and IRF-1 gene-deficient mice.
Immunological reviews 1998;165():149-66.
1998: H Yoshida; Young-Yun Kong; R Yoshida; Andrew Elia; Anne Hakem; Raza Hakem; Josef M Penninger; Tak W Mak
Apaf1 is required for mitochondrial pathways of apoptosis and brain development.
Cell 1998;94(6):739-50.
1998: Richard Boyd; Ivona Kozieradzki; Ann P Chidgey; HW Mittrücker; Denis Bouchard; E Timms; K Kishihara; Christopher J Ong; Daniel Chui; Jamey D Marth; Tak W Mak; Josef M Penninger
Receptor-specific allelic exclusion of TCRV alpha-chains during development.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1718-27.
1998: Raza Hakem; Anne Hakem; Gordon S Duncan; Dr. Jeffrey Henderson; Minna Woo; MS Soengas; Andrew Elia; José Luis de la Pompa; D Kagi; W Khoo; J Potter; R Yoshida; Stephen A Kaufman; Scott W Lowe; Josef M Penninger; Tak W Mak
Differential requirement for caspase 9 in apoptotic pathways in vivo.
Cell 1998;94(3):339-52.
1998: M Huber; E Timms; Tak W Mak; Martin Röllinghoff; Michael Lohoff
Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice.
Infection and immunity 1998;66(8):3968-70.
1998: David Andrew; JP Spellberg; H Takimoto; R Schmits; Tak W Mak; MM Zukowski
Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice.
European journal of immunology 1998;28(6):1959-69.
1998: K Saoulli; S Y Lee; Jennifer L Cannons; Wen-Chen Yeh; A Santana; MD Goldstein; Naveen Bangia; Mark DeBenedette; Tak W Mak; Y Choi; Tania H Watts
CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.
The Journal of experimental medicine 1998;187(11):1849-62.
1998: T Wen; L Trümper; W Fung-Leung; Amin Rahemtulla; E Klein; G Klein; Tak W Mak
Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts.
Immunology letters 1998;61(2-3):187-90.
1998: Kim J McKall-Faienza; K Kawai; TM Kündig; Bernhard Odermatt; Martin F Bachmann; Arsen Zakarian; Tak W Mak; Pamela S Ohashi
Absence of TNFRp55 influences virus-induced autoimmunity despite efficient lymphocytic infiltration.
International immunology 1998;10(4):405-12.
1998: Wen-Chen Yeh; J L Pompa; Mila E McCurrach; HB Shu; Andrew Elia; Arda Shahinian; M Ng; Andrew Wakeham; W Khoo; K Mitchell; Wafik S El-Deiry; Scott W Lowe; David V Goeddel; Tak W Mak
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.
Science (New York, N.Y.) 1998;279(5358):1954-8.
1998: Minna Woo; Raza Hakem; MS Soengas; Gordon S Duncan; Arda Shahinian; D Kägi; Anne Hakem; Mila E McCurrach; W Khoo; Stephen A Kaufman; Giorgio Senaldi; T Howard; Scott W Lowe; Tak W Mak
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes.
Genes & development 1998;12(6):806-19.
1998: José Luis de la Pompa; Luika Timmerman; H Takimoto; H Yoshida; Andrew Elia; E Samper; J Potter; Andrew Wakeham; L Marengere; B Lowell Langille; Gerald R Crabtree; Tak W Mak
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum.
Nature 1998;392(6672):182-6.
1998: Martin F Bachmann; P Waterhouse; DE Speiser; Kim J McKall-Faienza; Tak W Mak; Pamela S Ohashi
Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):95-100.
1998: H Yoshida; Hiroshi Nishina; H Takimoto; LE Marengère; Andrew Wakeham; Denis Bouchard; Young-Yun Kong; Toshiaki Ohteki; Arda Shahinian; M Bachmann; Pamela S Ohashi; Josef M Penninger; Gerald R Crabtree; Tak W Mak
The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.
Immunity 1998;8(1):115-24.
1998: C Sirard; José Luis de la Pompa; Andrew Elia; Annick Itie; Christine Mirtsos; A Cheung; S Hahn; Andrew Wakeham; L Schwartz; Scott E Kern; Janet Rossant; Tak W Mak
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.
Genes & development 1998;12(1):107-19.
1997: B Wang; H Fujisawa; L Zhuang; S Kondo; GM Shivji; C S Kim; Tak W Mak; Daniel N Sauder
Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6148-55.
1997: Toshiaki Ohteki; S Ho; H Suzuki; Tak W Mak; Pamela S Ohashi
Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5931-5.
1997: Wen-Chen Yeh; Arda Shahinian; D Speiser; J Kraunus; Filio Billia; Andrew Wakeham; José Luis de la Pompa; David A Ferrick; B Hum; Norman N Iscove; Pamela S Ohashi; M Rothe; David V Goeddel; Tak W Mak
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.
Immunity 1997;7(5):715-25.
1997: Martin F Bachmann; Kim J McKall-Faienza; R Schmits; Denis Bouchard; J Beach; DE Speiser; Tak W Mak; Pamela S Ohashi
Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation.
Immunity 1997;7(4):549-57.
1997: LE Marengère; Klaus Okkenhaug; A Clavreul; Dominique Couez; S Gibson; Gordon B Mills; Tak W Mak; Robert Rottapel
The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3220-9.
1997: R Schmits; J Filmus; Nicole Gerwin; Giorgio Senaldi; F Kiefer; T Kundig; Andrew Wakeham; Arda Shahinian; C Catzavelos; J Rak; Caren Furlonger; A Zakarian; J J Simard; Pamela S Ohashi; Christopher J Paige; Jose-Carlos Gutierrez-Ramos; Tak W Mak
CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity.
Blood 1997;90(6):2217-33.
1997: Hiroshi Nishina; M Bachmann; Antonio J Oliveira-dos-Santos; Ivona Kozieradzki; Klaus-Dieter Fischer; Bernhard Odermatt; Andrew Wakeham; Arda Shahinian; H Takimoto; alan bernstein; Tak W Mak; James R Woodgett; Pamela S Ohashi; Josef M Penninger
Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.
The Journal of experimental medicine 1997;186(6):941-53.
1997: Armin Reitmair; R Risley; Robert G Bristow; Teresa Wilson; A Ganesh; Anne Jang; Jim Peacock; Samuel Benchimol; Richard P Hill; Tak W Mak; Richard Fishel; Mark Meuth
Mutator phenotype in Msh2-deficient murine embryonic fibroblasts.
Cancer research 1997;57(17):3765-71.
1997: P Waterhouse; M F Bachmann; Josef M Penninger; Pamela S Ohashi; Tak W Mak
Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice.
European journal of immunology 1997;27(8):1887-92.
1997: Josef M Penninger; C Sirard; HW Mittrücker; Ann P Chidgey; Ivona Kozieradzki; Mai Nghiem; Anne Hakem; T Kimura; E Timms; R Boyd; T Taniguchi; Takeshi Matsuyama; Tak W Mak
The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.
Immunity 1997;7(2):243-54.
1997: Kurt Bachmaier; N Neu; CL Pummerer; Gordon S Duncan; Tak W Mak; Takeshi Matsuyama; Josef M Penninger
iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1.
Circulation 1997;96(2):585-91.
1997: Raza Hakem; José Luis de la Pompa; Andrew Elia; J Potter; Tak W Mak
Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.
Nature genetics 1997;16(3):298-302.
1997: LE Marengère; Christine Mirtsos; Ivona Kozieradzki; André Veillette; Tak W Mak; Josef M Penninger
Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):70-6.
1997: Michael Lohoff; David A Ferrick; H W Mittrucker; Gordon S Duncan; Susi Bischof; M Rollinghoff; Tak W Mak
Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo.
Immunity 1997;6(6):681-9.
1997: DE Speiser; Martin F Bachmann; T W Frick; Kim J McKall-Faienza; E Griffiths; K Pfeffer; Tak W Mak; Pamela S Ohashi
TNF receptor p55 controls early acute graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5185-90.
1997: A Suzuki; José Luis de la Pompa; Raza Hakem; Andrew Elia; R Yoshida; Rong Mo; Hiroshi Nishina; T Chuang; Andrew Wakeham; Annick Itie; W Koo; P Billia; Alexandra Ho; M Fukumoto; Chi-Chung Hui; Tak W Mak
Brca2 is required for embryonic cellular proliferation in the mouse.
Genes & development 1997;11(10):1242-52.
1997: E Sebzda; M Choi; W P Fung-Leung; Tak W Mak; Pamela S Ohashi
Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.
Immunity 1997;6(5):643-53.
1997: Lorrie Boucher; LE Marengère; Y Lu; S Thukral; Tak W Mak
Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.
Biochemical and biophysical research communications 1997;233(3):592-600.
1997: DE Speiser; Martin F Bachmann; Arda Shahinian; Tak W Mak; Pamela S Ohashi
Acute graft-versus-host disease without costimulation via CD28.
Transplantation 1997;63(7):1042-4.
1997: T Tamura; M Ishihara; M S Lamphier; N Tanaka; Isao Oishi; S Aizawa; T Matsuyama; Tak W Mak; S Taki; Tadatsugu Taniguchi
DNA damage-induced apoptosis and Ice gene induction in mitogenically activated T lymphocytes require IRF-1.
Leukemia 1997;11 Suppl 3():439-40.
1997: V A Wallace; Josef M Penninger; K Kishihara; E Timms; Arda Shahinian; H Pircher; TM Kündig; Pamela S Ohashi; Tak W Mak
Alterations in the level of CD45 surface expression affect the outcome of thymic selection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3205-14.
1997: Ivona Kozieradzki; TM Kündig; K Kishihara; Christopher J Ong; D Chiu; V A Wallace; K Kawai; E Timms; J Ionescu; Pamela S Ohashi; Jamey D Marth; Tak W Mak; Josef M Penninger
T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3130-9.
1997: R Lowsky; John F DeCoteau; Armin Reitmair; Ryo Ichinohasama; Wei-Feng Dong; Y Xu; Tak W Mak; Marshall E Kadin; Mark D Minden
Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL).
Blood 1997;89(7):2276-82.
1997: Kurt Bachmaier; CL Pummerer; Ivona Kozieradzki; K Pfeffer; Tak W Mak; N Neu; Josef M Penninger
Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease.
Circulation 1997;95(3):655-61.
1997: H Suzuki; Gordon S Duncan; H Takimoto; Tak W Mak
Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain.
The Journal of experimental medicine 1997;185(3):499-505.
1997: HW Mittrücker; Takeshi Matsuyama; A Grossman; TM Kündig; J Potter; Arda Shahinian; Andrew Wakeham; B Patterson; Pamela S Ohashi; Tak W Mak
Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.
Science (New York, N.Y.) 1997;275(5299):540-3.
1997: Hiroshi Nishina; Klaus-Dieter Fischer; LG Radvanyi; Arda Shahinian; Raza Hakem; EA Rubie; alan bernstein; Tak W Mak; James R Woodgett; Josef M Penninger
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3.
Nature 1997;385(6614):350-3.
1997: Y Tada; Alexandra Ho; Takeshi Matsuyama; Tak W Mak
Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1.
The Journal of experimental medicine 1997;185(2):231-8.
1997: Mark DeBenedette; Arda Shahinian; Tak W Mak; Tania H Watts
Costimulation of CD28- T lymphocytes by 4-1BB ligand.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):551-9.
1997: Martin F Bachmann; T M Kündig; DE Speiser; Kim J McKall-Faienza; K Kishara; Tak W Mak; Pamela S Ohashi
T-cell-independent antiviral B cell responses in CD45-deficient mice.
Cellular immunology 1997;175(1):12-5.
1996: Josef M Penninger; V A Wallace; T Molina; Tak W Mak
Lineage-specific control of superantigen-induced cell death by the protein tyrosine kinase p56(lck).
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5359-66.
1996: DE Speiser; E Sebzda; Toshiaki Ohteki; Martin F Bachmann; Klaus Pfeffer; Tak W Mak; Pamela S Ohashi
Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo.
European journal of immunology 1996;26(12):3055-60.
1996: Giorgio Senaldi; S Yin; Christine L Shaklee; P F Piguet; Tak W Mak; TR Ulich
Corynebacterium parvum- and Mycobacterium bovis bacillus Calmette-Guerin-induced granuloma formation is inhibited in TNF receptor I (TNF-RI) knockout mice and by treatment with soluble TNF-RI.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5022-6.
1996: Gordon S Duncan; Hans-Willi Mittrücker; D Kägi; Takeshi Matsuyama; Tak W Mak
The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo.
The Journal of experimental medicine 1996;184(5):2043-8.
1996: A Grossman; Hans-Willi Mittrücker; J Nicholl; A Suzuki; S Chung; L Antonio; S Suggs; G R Sutherland; David Siderovski; Tak W Mak
Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25.
Genomics 1996;37(2):229-33.
1996: P Waterhouse; LE Marengère; Hans-Willi Mittrücker; Tak W Mak
CTLA-4, a negative regulator of T-lymphocyte activation.
Immunological reviews 1996;153():183-207.
1996: Martin F Bachmann; E Sebzda; TM Kündig; Arda Shahinian; DE Speiser; Tak W Mak; Pamela S Ohashi
T cell responses are governed by avidity and co-stimulatory thresholds.
European journal of immunology 1996;26(9):2017-22.
1996: N Tanaka; M Ishihara; M S Lamphier; H Nozawa; T Matsuyama; Tak W Mak; Shin Aizawa; T Tokino; M Oren; Tadatsugu Taniguchi
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage.
Nature 1996;382(6594):816-8.
1996: Kurt Bachmaier; CL Pummerer; Arda Shahinian; J Ionescu; N Neu; Tak W Mak; Josef M Penninger
Induction of autoimmunity in the absence of CD28 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1752-7.
1996: Armin Reitmair; Mark Redston; J C Cai; T C Chuang; Matthew Bjerknes; Hazel Cheng; K Hay; Steven Gallinger; Bharati Bapat; Tak W Mak
Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.
Cancer research 1996;56(16):3842-9.
1996: TM Kündig; Arda Shahinian; K Kawai; Hans-Willi Mittrücker; E Sebzda; Martin F Bachmann; Tak W Mak; Pamela S Ohashi
Duration of TCR stimulation determines costimulatory requirement of T cells.
Immunity 1996;5(1):41-52.
1996: Armin Reitmair; J C Cai; Matthew Bjerknes; Mark Redston; Hazel Cheng; M T Pind; K Hay; A Mitri; Bharati Bapat; Tak W Mak; Steven Gallinger
MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis.
Cancer research 1996;56(13):2922-6.
1996: Raza Hakem; José Luis de la Pompa; C Sirard; Rong Mo; Minna Woo; Anne Hakem; Andrew Wakeham; J Potter; Armin Reitmair; Filio Billia; E Firpo; Chi-Chung Hui; J Roberts; Janet Rossant; Tak W Mak
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
Cell 1996;85(7):1009-23.
1996: B Wang; S Kondo; GM Shivji; H Fujisawa; Tak W Mak; Daniel N Sauder
Tumour necrosis factor receptor II (p75) signalling is required for the migration of Langerhans' cells.
Immunology 1996;88(2):284-8.
1996: Hans-Willi Mittrücker; Arda Shahinian; Denis Bouchard; TM Kündig; Tak W Mak
Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice.
The Journal of experimental medicine 1996;183(6):2481-8.
1996: LE Marengère; P Waterhouse; Gordon S Duncan; Hans-Willi Mittrücker; G S Feng; Tak W Mak
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.
Science (New York, N.Y.) 1996;272(5265):1170-3.
1996: Raymond S Yeung; Josef M Penninger; TM Kündig; W Khoo; P S Ohashi; G Kroemer; Tak W Mak
Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen-induced septic shock.
European journal of immunology 1996;26(5):1074-82.
1996: S Kondo; Stefan Beissert; B Wang; H Fujisawa; F Kooshesh; A Stratigos; Richard D Granstein; Tak W Mak; Daniel N Sauder
Hyporesponsiveness in contact hypersensitivity and irritant contact dermatitis in CD4 gene targeted mouse.
The Journal of investigative dermatology 1996;106(5):993-1000.
1996: A Suzuki; David Andrew; Jose-Angel Gonzalo; M Fukumoto; JP Spellberg; M Hashiyama; H Takimoto; Nicole Gerwin; I Webb; Graham Molineux; R Amakawa; Y Tada; Andrew Wakeham; J Brown; Ian K McNiece; K Ley; E C Butcher; T Suda; Jose-Carlos Gutierrez-Ramos; Tak W Mak
CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein.
Blood 1996;87(9):3550-62.
1996: R Schmits; TM Kündig; D M Baker; G Shumaker; J J Simard; G Duncan; Andrew Wakeham; Arda Shahinian; A van der Heiden; Martin F Bachmann; Pamela S Ohashi; Tak W Mak; Dennis D Hickstein
LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.
The Journal of experimental medicine 1996;183(4):1415-26.
1996: R Amakawa; Anne Hakem; T M Kundig; Takeshi Matsuyama; J J Simard; E Timms; Andrew Wakeham; H W Mittruecker; H Griesser; H Takimoto; R Schmits; Arda Shahinian; Pamela S Ohashi; Josef M Penninger; Tak W Mak
Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice.
Cell 1996;84(4):551-62.
1996: K Kawai; Arda Shahinian; Tak W Mak; Pamela S Ohashi
Skin allograft rejection in CD28-deficient mice.
Transplantation 1996;61(3):352-5.
1996: T Kimura; Y Kadokawa; H Harada; M Matsumoto; Masamitsu Sato; Y Kashiwazaki; M Tarutani; R S Tan; T Takasugi; T Matsuyama; Tak W Mak; S Noguchi; Tadatsugu Taniguchi
Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(1):115-24.
1996: T Benatar; Rita Carsetti; Caren Furlonger; N Kamalia; Tak W Mak; Christopher J Paige
Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.
The Journal of experimental medicine 1996;183(1):329-34.
1995: Tak W Mak
Funding, education, and training in the context of industry-academia relations.
The American journal of medicine 1995;99(6A):84S-86S.
1995: Hans-Willi Mittrücker; K Pfeffer; R Schmits; Tak W Mak
T-lymphocyte development and function in gene-targeted mutant mice.
Immunological reviews 1995;148():115-50.
1995: P Waterhouse; Josef M Penninger; E Timms; Andrew Wakeham; Arda Shahinian; K P Lee; Craig Thompson; H Griesser; Tak W Mak
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.
Science (New York, N.Y.) 1995;270(5238):985-8.
1995: T Wen; L Zhang; S K Kung; T J Molina; Richard G Miller; Tak W Mak
Allo-skin graft rejection, tumor rejection and natural killer activity in mice lacking p56lck.
European journal of immunology 1995;25(11):3155-9.
1995: Josef M Penninger; E Timms; Arda Shahinian; A Jezo-Bremond; Hiroshi Nishina; J Ionescu; S M Hedrick; Tak W Mak
Alloreactive gamma delta thymocytes utilize distinct costimulatory signals from peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3847-55.
1995: S Kondo; B Wang; H Fujisawa; GM Shivji; B Echtenacher; Tak W Mak; Daniel N Sauder
Effect of gene-targeted mutation in TNF receptor (p55) on contact hypersensitivity and ultraviolet B-induced immunosuppression.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3801-5.
1995: C Oka; Tomomi Nakano; Andrew Wakeham; José Luis de la Pompa; Chisato Mori; T Sakai; S Okazaki; M Kawaichi; K Shiota; Tak W Mak; Tasuku Honjo
Disruption of the mouse RBP-J kappa gene results in early embryonic death.
Development (Cambridge, England) 1995;121(10):3291-301.
1995: D R Koh; A Ho; Amin Rahemtulla; Wai-Ping Fung-Leung; H Griesser; Tak W Mak
Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells.
European journal of immunology 1995;25(9):2558-62.
1995: T Tamura; M Ishihara; M S Lamphier; N Tanaka; Isao Oishi; Shin Aizawa; T Matsuyama; Tak W Mak; Shinsuke Taki; Tadatsugu Taniguchi
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes.
Nature 1995;376(6541):596-9.
1995: HK Wu; Hong-Qiang Heng; XM Shi; Donald R Forsdyke; Lap-Chee Tsui; Tak W Mak; Mark D Minden; David Siderovski
Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31.
Leukemia 1995;9(8):1291-8.
1995: Josef M Penninger; M W Schilham; E Timms; V A Wallace; Tak W Mak
T cell repertoire and clonal deletion of Mtv superantigen-reactive T cells in mice lacking CD4 and CD8 molecules.
European journal of immunology 1995;25(7):2115-8.
1995: Takeshi Matsuyama; A Grossman; Hans-Willi Mittrücker; David Siderovski; F Kiefer; T Kawakami; Christopher D Richardson; T Taniguchi; S K Yoshinaga; Tak W Mak
Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE).
Nucleic acids research 1995;23(12):2127-36.
1995: Josef M Penninger; T Wen; E Timms; J Potter; V A Wallace; T Matsuyama; D Ferrick; Beate C Sydora; Mitchell Kronenberg; Tak W Mak
Spontaneous resistance to acute T-cell leukaemias in TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice.
Nature 1995;375(6528):241-4.
1995: Wai-Ping Fung-Leung; Kenji Kishihara; D Gray; H S Teh; C Y Lau; Tak W Mak
Intestinal T cells in CD8 alpha knockout mice and T cell receptor transgenic mice.
Advances in experimental medicine and biology 1995;371A():121-4.
1995: K Kawai; Kenji Kishihara; T J Molina; V A Wallace; Tak W Mak; Pamela S Ohashi
Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice.
The Journal of experimental medicine 1995;181(1):345-9.
1994: Josef M Penninger; Tak W Mak
Signal transduction, mitotic catastrophes, and death in T-cell development.
Immunological reviews 1994;142():231-72.
1994: Raymond S Yeung; Josef M Penninger; TM Kündig; Y Law; K Yamamoto; N Kamikawaji; L Burkly; T Sasazuki; R Flavell; Pamela S Ohashi; Tak W Mak
Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.
The Journal of experimental medicine 1994;180(5):1911-20.
1994: Wai-Ping Fung-Leung; TM Kündig; Karen Ngo; J Panakos; J De Sousa-Hitzler; E Wang; Pamela S Ohashi; Tak W Mak; C Y Lau
Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.
The Journal of experimental medicine 1994;180(3):959-67.
1994: D R Koh; A Ho; Amin Rahemtulla; Josef M Penninger; Tak W Mak
Experimental allergic encephalomyelitis (EAE) in mice lacking CD4+ T cells.
European journal of immunology 1994;24(9):2250-3.
1994: Amin Rahemtulla; TM Kündig; A Narendran; M F Bachmann; M Julius; Christopher J Paige; Pamela S Ohashi; Rolf M Zinkernagel; Tak W Mak
Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice.
European journal of immunology 1994;24(9):2213-8.
1994: P Mombaerts; S J Anderson; Roger M Perlmutter; Tak W Mak; Susumu Tonegawa
An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.
Immunity 1994;1(4):261-7.
1994: T Kimura; K Nakayama; J Penninger; M Kitagawa; H Harada; T Matsuyama; N Tanaka; R Kamijo; J Vilcek; Tak W Mak
Involvement of the IRF-1 transcription factor in antiviral responses to interferons.
Science (New York, N.Y.) 1994;264(5167):1921-4.
1994: N Tanaka; M Ishihara; M Kitagawa; H Harada; T Kimura; T Matsuyama; M S Lamphier; Shin Aizawa; Tak W Mak; Tadatsugu Taniguchi
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.
Cell 1994;77(6):829-39.
1994: V A Wallace; S Kondo; T Kono; Zhou Xing; E Timms; Caren Furlonger; E Keystone; Jack Gauldie; Daniel N Sauder; Tak W Mak
A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice.
European journal of immunology 1994;24(6):1463-6.
1994: Josef M Penninger; V A Wallace; E Timms; Tak W Mak
Maternal transfer of infectious mouse mammary tumor retroviruses does not depend on clonal deletion of superantigen-reactive V beta 14+ T cells.
European journal of immunology 1994;24(5):1102-8.
1994: Raymond S Yeung; Josef M Penninger; Tak W Mak
T-cell development and function in gene-knockout mice.
Current opinion in immunology 1994;6(2):298-307.
1994: E Sebzda; V A Wallace; J Mayer; Raymond S Yeung; Tak W Mak; Pamela S Ohashi
Positive and negative thymocyte selection induced by different concentrations of a single peptide.
Science (New York, N.Y.) 1994;263(5153):1615-8.
1994: L Zhang; J Shannon; J Sheldon; H S Teh; Tak W Mak; Richard G Miller
Role of infused CD8+ cells in the induction of peripheral tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2222-8.
1994: Brent Zanke; J Squire; H Griesser; M Henry; H Suzuki; B Patterson; Mark D Minden; Tak W Mak
A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1.
Leukemia 1994;8(2):236-44.
1994: H Griesser; Tak W Mak
The T-cell receptor--structure, function, and clinical application.
Hematologic pathology 1994;8(1-2):1-23.
1994: D A Ferrick; L Gemmell-Hori; Beate C Sydora; T Mulvania; Josef M Penninger; Mitchell Kronenberg; Tak W Mak
Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice.
International reviews of immunology 1994;11(4):295-304.
1993: Josef M Penninger; N Neu; E Timms; V A Wallace; D R Koh; Kenji Kishihara; CL Pummerer; Tak W Mak
The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected].
The Journal of experimental medicine 1993;178(5):1837-42.
1993: Wai-Ping Fung-Leung; M C Louie; A Limmer; Pamela S Ohashi; Karen Ngo; L Chen; K Kawai; Elizabeth Lacy; D Y Loh; Tak W Mak
The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes.
European journal of immunology 1993;23(11):2834-40.
1993: Amin Rahemtulla; Arda Shahinian; T Kundig; Rolf M Zinkernagel; Tak W Mak
CD4 negative mice as a model for immunodeficiency.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;342(1299):57-8.
1993: Josef M Penninger; V A Wallace; Kenji Kishihara; Tak W Mak
The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection.
Immunological reviews 1993;135():183-214.
1993: I T Chan; A Limmer; M C Louie; E D Bullock; Wai-Ping Fung-Leung; Tak W Mak; D Y Loh
Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association.
Science (New York, N.Y.) 1993;261(5128):1581-4.
1993: Raymond S Yeung; Josef M Penninger; Tak W Mak
Genetically modified animals and immunodeficiency.
Current opinion in immunology 1993;5(4):585-94.
1993: Arda Shahinian; Klaus Pfeffer; K P Lee; TM Kündig; Kenji Kishihara; Andrew Wakeham; K Kawai; Pamela S Ohashi; Craig Thompson; Tak W Mak
Differential T cell costimulatory requirements in CD28-deficient mice.
Science (New York, N.Y.) 1993;261(5121):609-12.
1993: T J Molina; Martin F Bachmann; TM Kündig; Rolf M Zinkernagel; Tak W Mak
Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):699-706.
1993: M W Schilham; Wai-Ping Fung-Leung; Amin Rahemtulla; T Kuendig; L Zhang; J Potter; Richard G Miller; H Hengartner; Tak W Mak
Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8.
European journal of immunology 1993;23(6):1299-304.
1993: Klaus Pfeffer; Takeshi Matsuyama; TM Kündig; Andrew Wakeham; Kenji Kishihara; Arda Shahinian; Katja Wiegmann; Pamela S Ohashi; M Krönke; Tak W Mak
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.
Cell 1993;73(3):457-67.
1993: Josef M Penninger; Kenji Kishihara; T Molina; V A Wallace; E Timms; S M Hedrick; Tak W Mak
Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells.
Science (New York, N.Y.) 1993;260(5106):358-61.
1993: Wai-Ping Fung-Leung; V A Wallace; D Gray; W C Sha; Hanspeter Pircher; H S Teh; D Y Loh; Tak W Mak
CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny.
European journal of immunology 1993;23(1):212-6.
1992: V A Wallace; Wai-Ping Fung-Leung; E Timms; D Gray; Kenji Kishihara; D Y Loh; Josef M Penninger; Tak W Mak
CD45RA and CD45RBhigh expression induced by thymic selection events.
The Journal of experimental medicine 1992;176(6):1657-63.
1992: V A Wallace; Amin Rahemtulla; E Timms; Josef M Penninger; Tak W Mak
CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.
The Journal of experimental medicine 1992;176(5):1459-63.
1992: David Siderovski; T Matsuyama; E Frigerio; S Chui; X Min; H Erfle; M Sumner-Smith; R W Barnett; Tak W Mak
Random mutagenesis of the human immunodeficiency virus type-1 trans-activator of transcription (HIV-1 Tat).
Nucleic acids research 1992;20(20):5311-20.
1992: L H Trümper; G Brady; Stefano Vicini; J Cossman; Tak W Mak
Gene expression in single Reed Sternberg cells of Hodgkin's disease: results from PCR generated single cell cDNA libraries.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1992;3 Suppl 4():25-6.
1992: D R Koh; Wai-Ping Fung-Leung; A Ho; D Gray; H Acha-Orbea; Tak W Mak
Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice.
Science (New York, N.Y.) 1992;256(5060):1210-3.
1992: Tak W Mak; Amin Rahemtulla; M Schilham; D R Koh; Wai-Ping Fung-Leung
Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting.
Journal of autoimmunity 1992;5 Suppl A():55-9.
1992: Brent Zanke; H Suzuki; Kenji Kishihara; L Mizzen; Mark D Minden; A Pawson; Tak W Mak
Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase).
European journal of immunology 1992;22(1):235-9.
1992: Tak W Mak; Amin Rahemtulla; M Schilham; D R Koh; Wai-Ping Fung-Leung
Generation of mutant mice lacking surface expression of CD4 or CD8 gene targeting.
Advances in experimental medicine and biology 1992;323():73-7.
1991: MD Reis; H Griesser; Tak W Mak
Antigen receptor genes in hemopoietic malignancies.
Biochimica et biophysica acta 1991;1072(2-3):177-92.
1991: Wai-Ping Fung-Leung; TM Kündig; Rolf M Zinkernagel; Tak W Mak
Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression.
The Journal of experimental medicine 1991;174(6):1425-9.
1991: Junichi Hara; Y Takihara; Keiko Yumura-Yagi; S Ishihara; Akio Tawa; Tak W Mak; E W Gelfand; Shintaro Okada; K Kawa-Ha
Differential usage of delta recombining element and V delta genes during T-cell ontogeny.
Blood 1991;78(8):2075-81.
1991: H Martinez-Valdez; Y Takihara; E Champagne; Mark D Minden; Tak W Mak; A Cohen
Differential regulation of gamma and delta T cell antigen receptor gene expression by phorbol esters and Ca2+ ionophores in the acute lymphocyte leukemia DND41 cell line.
European journal of immunology 1991;21(10):2625-8.
1991: D A Ferrick; A Cumano; Caren Furlonger; X Min; Norman N Iscove; Christopher J Paige; Tak W Mak
Expansion of myelopoietic precursors and inhibition of B-cell precursors in mice that express a T-cell receptor gamma (V gamma 1.1J gamma 4C gamma 4) transgene.
Journal of cellular physiology 1991;148(3):457-63.
1991: D Brändle; K Bürki; V A Wallace; Urs Hoffmann-Rohrer; Tak W Mak; B Malissen; Hans Hengartner; Hanspeter Pircher
Involvement of both T cell receptor V alpha and V beta variable region domains and alpha chain junctional region in viral antigen recognition.
European journal of immunology 1991;21(9):2195-202.
1991: Junichi Hara; K Kawa-Ha; Y Takihara; Keiko Yumura-Yagi; S Ishihara; Akio Tawa; Tak W Mak; Shintaro Okada; E W Gelfand
Developmental process of the T-cell receptor alpha and delta gene assembly in B-cell precursor acute lymphoblastic leukaemia.
British journal of haematology 1991;78(2):180-6.
1991: Wai-Ping Fung-Leung; M W Schilham; Amin Rahemtulla; TM Kündig; M Vollenweider; J Potter; W van Ewijk; Tak W Mak
CD8 is needed for development of cytotoxic T cells but not helper T cells.
Cell 1991;65(3):443-9.
1991: D A Ferrick; Beate C Sydora; V Wallace; L Gemmell-Hori; Mitchell Kronenberg; Tak W Mak
Self-reactive gamma delta T lymphocytes: implications for T-cell ontogeny and reactivity.
Immunological reviews 1991;120():51-69.
1991: S H Cheng; Josef M Penninger; D A Ferrick; T J Molina; V A Wallace; Tak W Mak
Biology of murine gamma delta T cells.
Critical reviews in immunology 1991;11(3-4):145-66.
1991: Josef M Penninger; V A Wallace; Kenji Kishihara; T Molina; H Krause; Tak W Mak
Molecular organization, ontogeny and expression of murine alpha beta and gamma delta T cell receptors.
Experimental and clinical immunogenetics 1991;8(2):57-74.
1991: M J Sheehy; C A Emler; Tak W Mak; Janardan P Pandey
Human genes for the immunoglobulin gamma-chain (Gm) allotypes and for the T cell receptor alpha-chain are distantly linked or unlinked.
Experimental and clinical immunogenetics 1991;8(1):6-10.
1991: D A Ferrick; D Gajewski; Tak W Mak
First wave fetal thymocytes expressing V3J gamma 1C gamma 1-V delta 1J delta 2C delta T cell receptors are not required for alpha beta T cell receptor rearrangement and expression.
Advances in experimental medicine and biology 1991;292():47-51.
1990: Tak W Mak
Molecular similarities and differences between immunoglobulin and T cell receptors.
Behring Institute Mitteilungen 1990;(87):1-9.
1990: D A Ferrick; Pamela S Ohashi; V A Wallace; M Schilham; Tak W Mak
Transgenic mice as an in vivo model for self-reactivity.
Immunological reviews 1990;118():257-83.
1990: V A Wallace; Pamela S Ohashi; H Hengartner; Tak W Mak
Expression of CD4 can confer major histocompatibility complex class II-associated superantigen reactivity upon a T cell receptor derived from a CD8-dependent cytotoxic T lymphocyte clone.
European journal of immunology 1990;20(11):2471-7.
1990: Pamela S Ohashi; V A Wallace; H Broughton; C T Ohashi; D A Ferrick; V Jost; Tak W Mak; Hans Hengartner; Hanspeter Pircher
Specific deletion of the J-C delta locus in murine alpha/beta T cell clones and studies using transgenic mice.
European journal of immunology 1990;20(3):517-22.
1990: Hanspeter Pircher; Pamela S Ohashi; G Miescher; R Lang; A Zikopoulos; K Bürki; Tak W Mak; H R MacDonald; Hans Hengartner
T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population.
European journal of immunology 1990;20(2):417-24.
1990: MD Reis; H Griesser; Tak W Mak
T cell receptor and immunoglobulin genes in hematologic malignancies.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1990;11 Suppl 1():59-77.
1990: A Chan; R P Du; M Reis; L M Meske; M Sheehy; E Baillie; Tak W Mak
Human T cell receptor V alpha gene polymorphism.
Experimental and clinical immunogenetics 1990;7(1):26-33.
1989: D A Ferrick; Pamela S Ohashi; V Wallace; M Schilham; Tak W Mak
Thymic ontogeny and selection of alpha beta and gamma delta T cells.
Immunology today 1989;10(12):403-7.
1989: M J Sheehy; L M Meske; C A Emler; J R Rowe; M H Neme de Gimenez; C A Ingle; A Chan; Massimo Trucco; Tak W Mak
Allelic T-cell receptor alpha complexes have little or no influence on susceptibility to type 1 diabetes.
Human immunology 1989;26(4):261-71.
1989: Keiko Yumura-Yagi; Junichi Hara; N Terada; S Ishihara; Akio Tawa; Y Takihara; E Champagne; Mark D Minden; Tak W Mak; K Kawa-Ha
Analysis of molecular events in leukemic cells arrested at an early stage of T-cell differentiation.
Blood 1989;74(6):2103-11.
1989: Junichi Hara; Keiko Yumura-Yagi; Akio Tawa; S Ishihara; M Murata; N Terada; Y Izumi; E Champagne; Y Takihara; Tak W Mak
Molecular analysis of acute undifferentiated leukemia: two distinct subgroups at the DNA and RNA levels.
Blood 1989;74(5):1738-46.
1989: D A Ferrick; S R Sambhara; W Ballhausen; A Iwamoto; Hanspeter Pircher; C L Walker; W M Yokoyama; Richard G Miller; Tak W Mak
T cell function and expression are dramatically altered in T cell receptor V gamma 1.1J gamma 4C gamma 4 transgenic mice.
Cell 1989;57(3):483-92.
1989: T Takadera; S Leung; A Gernone; Y Koga; Y Takihara; N G Miyamoto; Tak W Mak
Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells.
Molecular and cellular biology 1989;9(5):2173-80.
1989: H Griesser; D Tkachuk; MD Reis; Tak W Mak
Gene rearrangements and translocations in lymphoproliferative diseases.
Blood 1989;73(6):1402-15.
1989: E Champagne; Y Takihara; U Sagman; J de Sousa; S Burrow; W H Lewis; Tak W Mak; Mark D Minden
The T-cell receptor delta chain locus is disrupted in the T-ALL associated t(11;14)(p13;q11) translocation.
Blood 1989;73(6):1672-6.
1989: Hanspeter Pircher; Tak W Mak; R Lang; W Ballhausen; E Rüedi; Hans Hengartner; Rolf M Zinkernagel; K Bürki
T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.
The EMBO journal 1989;8(3):719-27.
1989: Y Takihara; E Champagne; E Ciccone; L Moretta; Mark D Minden; Tak W Mak
Organization and orientation of a human T cell receptor delta chain V gene segment that suggests an inversion mechanism is utilized in its rearrangement.
European journal of immunology 1989;19(3):571-4.
1989: N Caccia; Tak W Mak
Human T cell receptors.
Transplantation proceedings 1989;21(1 Pt 1):18-21.
1989: Y Takihara; J Reimann; E Michalopoulos; E Ciccone; L Moretta; Tak W Mak
Diversity and structure of human T cell receptor delta chain genes in peripheral blood gamma/delta-bearing T lymphocytes.
The Journal of experimental medicine 1989;169(2):393-405.
1989: Junichi Hara; Stephen H Benedict; E Champagne; Tak W Mak; Mark D Minden; Erwin W Gelfand
Relationship between rearrangement and transcription of the T-cell receptor alpha, beta, and gamma genes in B-precursor acute lymphoblastic leukemia.
Blood 1989;73(2):500-8.
1989: MD Reis; H Griesser; Tak W Mak
T cell receptor and immunoglobulin gene rearrangements in lymphoproliferative disorders.
Advances in cancer research 1989;52():45-80.
1989: D A Ferrick; S R Sambhara; B S Chadwick; Richard G Miller; Tak W Mak
The T-cell receptor repertoire is strikingly similar in older nude mice compared to normal adult mice.
Thymus 1989;13(1-2):103-11.
1989: A Chan; R P Du; M Reis; E Baillie; L M Meske; M Sheehy; Tak W Mak
Polymorphism of the human T cell receptor alpha chain variable genes: identification of a highly polymorphic V gene probe.
International immunology 1989;1(3):267-72.
1989: D A Ferrick; X Min; D A Gajewski; Tak W Mak
Phenotypic analysis of mice transgenic for the TCR C gamma 4 (V gamma 1.1J gamma 4C gamma 4) gene.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():57-60.
1989: J P Dutz; A Chan; Tak W Mak; K A Siminovitch; L A Rubin
T cell receptor genes in rheumatoid arthritis.
Springer seminars in immunopathology 1989;11(3):289-99.
1989: Y Takihara; N Caccia; Y Yangai; Tak W Mak
Isolation of a T cell specific cDNA clone possibly involved in the T cell activation pathway.
International immunology 1989;1(1):59-65.
1988: N Caccia; Tak W Mak
T cell receptors.
The American journal of medicine 1988;85(6A):9-11.
1988: Junichi Hara; Stephen H Benedict; E Champagne; Y Takihara; Tak W Mak; Mark D Minden; Erwin W Gelfand
T cell receptor delta gene rearrangements in acute lymphoblastic leukemia.
The Journal of clinical investigation 1988;82(6):1974-82.
1988: E Champagne; Y Takihara; U Sagman; S Burrow; J de Sousa; Tak W Mak; Mark D Minden
The isolation of the human delta chain gene and its expression in normal T cells and T cell leukemias.
Leukemia 1988;2(11):717-21.
1988: Y Takihara; D Tkachuk; E Michalopoulos; E Champagne; J Reimann; Mark D Minden; Tak W Mak
Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):6097-101.
1988: D C Tkachuk; H Griesser; Y Takihara; E Champagne; Mark D Minden; A C Feller; K Lennert; Tak W Mak
Rearrangement of T-cell delta locus in lymphoproliferative disorders.
Blood 1988;72(1):353-7.
1988: H Griesser; Tak W Mak
Immunogenotyping in Hodgkin's disease.
Hematological oncology 1988;6(3):239-45.
1988: E Champagne; U Sagman; A Biondi; W H Lewis; Tak W Mak; Mark D Minden
Structure and rearrangement of the T cell receptor J alpha locus in T cells and leukemic T cell lines.
European journal of immunology 1988;18(7):1033-8.
1988: Y Koga; E Lindstrom; E M Fenyo; H Wigzell; Tak W Mak
High levels of heterodisperse RNAs accumulate in T cells infected with human immunodeficiency virus and in normal thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4521-5.
1988: Junichi Hara; Stephen H Benedict; E Champagne; Tak W Mak; Mark D Minden; Erwin W Gelfand
Comparison of T cell receptor alpha, beta, and gamma gene rearrangement and expression in T cell acute lymphoblastic leukemia.
The Journal of clinical investigation 1988;81(4):989-96.
1988: W G Ballhausen; A B Reske-Kunz; B Tourvieille; Pamela S Ohashi; Jane R Parnes; Tak W Mak
Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma.
The Journal of experimental medicine 1988;167(4):1493-8.
1988: H Griesser; E Champagne; D Tkachuk; Y Takihara; M Lalande; E Baillie; Mark D Minden; Tak W Mak
The human T cell receptor alpha-delta locus: a physical map of the variable, joining and constant region genes.
European journal of immunology 1988;18(4):641-4.
1988: Y Koga; N Kimura; J Minowada; Tak W Mak
Expression of the human T-cell-specific tyrosine kinase YT16 (lck) message in leukemic T-cell lines.
Cancer research 1988;48(4):856-9.
1988: R Spolski; G Miescher; F Erard; R Risser; H R MacDonald; Tak W Mak
Regulation of expression of T cell gamma chain, L3T4 and Ly-2 messages in Abelson/Moloney virus-transformed T cell lines.
European journal of immunology 1988;18(2):295-300.
1987: Junichi Hara; Stephen H Benedict; Tak W Mak; Erwin W Gelfand
T cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia.
The Journal of clinical investigation 1987;80(6):1770-7.
1987: Hanspeter Pircher; E E Michalopoulos; A Iwamoto; Pamela S Ohashi; J Baenziger; H Hengartner; Rolf M Zinkernagel; Tak W Mak
Molecular analysis of the antigen receptor of virus-specific cytotoxic T cells and identification of a new V alpha family.
European journal of immunology 1987;17(12):1843-6.
1987: N Kimura; R P Du; Tak W Mak
Rearrangement and organization of T cell receptor gamma chain genes in human leukemic T cell lines.
European journal of immunology 1987;17(11):1653-6.
1987: MD Reis; Tak W Mak
Monoclonality in human T-cell disorders.
Blood reviews 1987;1(2):89-96.
1981: D Mager; M E MacDonald; I B Robson; Tak W Mak; A Bernstein
Clonal analysis of the late stages of erythroleukemia induced by two distinct strains of Friend leukemia virus.
Molecular and cellular biology 1981;1(8):721-30.