Tak Mak

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Kayama Hisako; Koga Ritsuko; Atarashi Koji; Okuyama Megumi; Kimura Taishi; Mak Tak W; Uematsu Satoshi; Akira Shizuo; Takayanagi Hiroshi; Honda Kenya; Yamamoto Masahiro; Takeda Kiyoshi
NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.
Reardon Colin; Mak Tak W
cIAP proteins: keystones in NOD receptor signal transduction.
Raffatellu Manuela; George Michael D; Akiyama Yuko; Hornsby Michael J; Nuccio Sean-Paul; Paixao Tatiane A; Butler Brian P; Chu Hiutung; Santos Renato L; Berger Thorsten; Mak Tak W; Tsolis Renée M; Bevins Charles L; Solnick Jay V; Dandekar Satya; Bäumler Andreas J
Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine.

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All Publications

2009: Kayama Hisako; Koga Ritsuko; Atarashi Koji; Okuyama Megumi; Kimura Taishi; Mak Tak W; Uematsu Satoshi; Akira Shizuo; Takayanagi Hiroshi; Honda Kenya; Yamamoto Masahiro; Takeda Kiyoshi
NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.
PLoS pathogens 2009;5(7):e1000514.
2009: Reardon Colin; Mak Tak W
cIAP proteins: keystones in NOD receptor signal transduction.
Immunity 2009;30(6):755-6.
2009: Raffatellu Manuela; George Michael D; Akiyama Yuko; Hornsby Michael J; Nuccio Sean-Paul; Paixao Tatiane A; Butler Brian P; Chu Hiutung; Santos Renato L; Berger Thorsten; Mak Tak W; Tsolis Renée M; Bevins Charles L; Solnick Jay V; Dandekar Satya; Bäumler Andreas J
Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine.
Cell host & microbe 2009;5(5):476-86.
2009: Pellegrini Marc; Calzascia Thomas; Elford Alisha R; Shahinian Arda; Lin Amy E; Dissanayake Dilan; Dhanji Salim; Nguyen Linh T; Gronski Matthew A; Morre Michel; Assouline Brigitte; Lahl Katharina; Sparwasser Tim; Ohashi Pamela S; Mak Tak W
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.
Nature medicine 2009;15(5):528-36.
2009: Chan Yvonne R; Liu Jessica S; Pociask Derek A; Zheng Mingquan; Mietzner Timothy A; Berger Thorsten; Mak Tak W; Clifton Matthew C; Strong Roland K; Ray Prabir; Kolls Jay K
Lipocalin 2 is required for pulmonary host defense against Klebsiella infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4947-56.
2009: Mei Yang; Zhang Yiru; Yamamoto Kazuo; Xie Wei; Mak Tak W; You Han
FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5153-8.
2009: Vernole Patrizia; Neale Michael H; Barcaroli Daniela; Munarriz Eliana; Knight Richard A; Tomasini Richard; Mak Tak W; Melino Gerry; De Laurenzi Vincenzo
TAp73alpha binds the kinetochore proteins Bub1 and Bub3 resulting in polyploidy.
Cell cycle (Georgetown, Tex.) 2009;8(3):421-9.
2009: Tomasini Richard; Tsuchihara Katsuya; Tsuda Chiharu; Lau Suzanne K; Wilhelm Margareta; Ruffini Alessandro; Tsao Ming-sound; Iovanna Juan L; Jurisicova Andrea; Melino Gerry; Mak Tak W
TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):797-802.
2009: Kaufmann Thomas; Jost Philipp J; Pellegrini Marc; Puthalakath Hamsa; Gugasyan Raffi; Gerondakis Steve; Cretney Erika; Smyth Mark J; Silke John; Hakem Razq; Bouillet Philippe; Mak Tak W; Dixit Vishva M; Strasser Andreas
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.
Immunity 2009;30(1):56-66.
2009: Radziszewska Anna; Choi Diana; Nguyen Kinh-Tung T; Schroer Stephanie A; Tajmir Panteha; Wang Linyuan; Suzuki Akira; Mak Tak W; Evan Gerard I; Woo Minna
PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells.
The Journal of biological chemistry 2009;284(5):2917-22.
2008: Zarnegar Brian J; Wang Yaya; Mahoney Douglas J; Dempsey Paul W; Cheung Herman H; He Jeannie; Shiba Travis; Yang Xiaolu; Yeh Wen-Chen; Mak Tak W; Korneluk Robert G; Cheng Genhong
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
Nature immunology 2008;9(12):1371-8.
2008: Wang Feng; Marshall Christopher B; Yamamoto Kazuo; Li Guang-Yao; Plevin Michael J; You Han; Mak Tak W; Ikura Mitsuhiko
Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53.
Journal of molecular biology 2008;384(3):590-603.
2008: Kim Jin Woo; Kang Kyung Hwa; Burrola Patrick; Mak Tak W; Lemke Greg
Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium.
Genes & development 2008;22(22):3147-57.
2008: Hao Zhenyue; Duncan Gordon S; Seagal Jane; Su Yu-Wen; Hong Claire; Haight Jillian; Chen Nien-Jung; Elia Andrew; Wakeham Andrew; Li Wanda Y; Liepa Jennifer; Wood Geoffrey A; Casola Stefano; Rajewsky Klaus; Mak Tak W
Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.
Immunity 2008;29(4):615-27.
2008: Tomasini Richard; Tsuchihara Katsuya; Wilhelm Margareta; Fujitani Masashi; Rufini Alessandro; Cheung Carol C; Khan Fatima; Itie-Youten Annick; Wakeham Andrew; Tsao Ming-Sound; Iovanna Juan L; Squire Jeremy; Jurisica Igor; Kaplan David; Melino Gerry; Jurisicova Andrea; Mak Tak W
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.
Genes & development 2008;22(19):2677-91.
2008: Rumble Julie M; Bertrand Mathieu J M; Csomos Rebecca A; Wright Casey W; Albert Lori; Mak Tak W; Barker Philip A; Duckett Colin S
Apoptotic sensitivity of murine IAP-deficient cells.
The Biochemical journal 2008;415(1):21-5.
2008: Knobbe C B; Lapin V; Suzuki A; Mak T W
The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey.
Oncogene 2008;27(41):5398-415.
2008: Choi Diana; Nguyen Kinh-Tung T; Wang Linyuan; Schroer Stephanie A; Suzuki Akira; Mak Tak W; Woo Minna
Partial deletion of Pten in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone.
Endocrinology 2008;149(9):4382-6.
2008: Chen Nien-Jung; Chio Iok In Christine; Lin Wen-Jye; Duncan Gordon; Chau Hien; Katz David; Huang Huey-Lan; Pike Kelly A; Hao Zhenyue; Su Yu-Wen; Yamamoto Kazuo; de Pooter Renée F; Zúñiga-Pflücker Juan Carlos; Wakeham Andrew; Yeh Wen-Chen; Mak Tak W
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12429-34.
2008: Lechmann Matthias; Shuman Naomi; Wakeham Andrew; Mak Tak W
The CD83 reporter mouse elucidates the activity of the CD83 promoter in B, T, and dendritic cell populations in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11887-92.
2008: Ow Yong-Ling P; Green Douglas R; Hao Zhenyue; Mak Tak W
Cytochrome c: functions beyond respiration.
Nature reviews. Molecular cell biology 2008;9(7):532-42.
2008: Berezovski Maxim V; Lechmann Matthias; Musheev Michael U; Mak Tak W; Krylov Sergey N
Aptamer-facilitated biomarker discovery (AptaBiD).
Journal of the American Chemical Society 2008;130(28):9137-43.
2008: Arpaia Enrico; Mak Tak W
Micromanagement of lymphomas.
PLoS biology 2008;6(6):e156.
2008: Tomasini Richard; Mak Tak W; Melino Gerry
The impact of p53 and p73 on aneuploidy and cancer.
Trends in cell biology 2008;18(5):244-52.
2008: Kuroda Shoko; Nishio Miki; Sasaki Takehiko; Horie Yasuo; Kawahara Koichi; Sasaki Masato; Natsui Miyuki; Matozaki Takashi; Tezuka Hiroyuki; Ohteki Toshiaki; Förster Irmgard; Mak Tak W; Nakano Toru; Suzuki Akira
Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages.
European journal of immunology 2008;38(5):1331-40.
2008: Dufner Almut; Duncan Gordon S; Wakeham Andrew; Elford Alisha R; Hall Håkan T; Ohashi Pamela S; Mak Tak W
CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.
Molecular and cellular biology 2008;28(5):1541-52.
2008: Calzascia Thomas; Pellegrini Marc; Lin Albert; Garza Kristine M; Elford Alisha R; Shahinian Arda; Ohashi Pamela S; Mak Tak W
CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2999-3004.
2008: Emerling Brooke M; Weinberg Frank; Liu Juinn-Lin; Mak Tak W; Chandel Navdeep S
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2622-7.
2008: Xue Ling; Nolla Hector; Suzuki Akira; Mak Tak W; Winoto Astar
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):2022-7.
2008: Hall Håkan T L; Wilhelm Margareta T; Saibil Samuel D; Mak Tak W; Flavell Richard A; Ohashi Pamela S
RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses.
European journal of immunology 2008;38(1):64-72.
2007: Bakker Walbert J; Harris Isaac S; Mak Tak W
FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2.
Molecular cell 2007;28(6):941-53.
2007: Lin Amy Erica; Mak Tak W
The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells.
Current opinion in immunology 2007;19(6):665-73.
2007: Calzascia Thomas; Pellegrini Marc; Hall Håkan; Sabbagh Laurent; Ono Nobuyuki; Elford Alisha R; Mak Tak W; Ohashi Pamela S
TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice.
The Journal of clinical investigation 2007;117(12):3833-45.
2007: Aleyasin Hossein; Rousseaux Maxime W C; Phillips Maryam; Kim Raymond H; Bland Ross J; Callaghan Steve; Slack Ruth S; During Matthew J; Mak Tak W; Park David S
The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18748-53.
2007: Mak Tak W
The T cell antigen receptor: "The Hunting of the Snark".
European journal of immunology 2007;37 Suppl 1():S83-93.
2007: Brüstle Anne; Heink Sylvia; Huber Magdalena; Rosenplänter Christine; Stadelmann Christine; Yu Philipp; Arpaia Enrico; Mak Tak W; Kamradt Thomas; Lohoff Michael
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4.
Nature immunology 2007;8(9):958-66.
2007: Ho Andrew T; Li Qin H; Okada Hitoshi; Mak Tak W; Zacksenhaus Eldad
XIAP activity dictates Apaf-1 dependency for caspase 9 activation.
Molecular and cellular biology 2007;27(16):5673-85.
2007: Bakker Walbert J; van Dijk Thamar B; Parren-van Amelsvoort Martine; Kolbus Andrea; Yamamoto Kazuo; Steinlein Peter; Verhaak Roel G W; Mak Tak W; Beug Hartmut; Löwenberg Bob; von Lindern Marieke
Differential regulation of Foxo3a target genes in erythropoiesis.
Molecular and cellular biology 2007;27(10):3839-3854.
2007: Pan James G; Mak Tak W
Metabolic targeting as an anticancer strategy: dawn of a new era?
Science's STKE : signal transduction knowledge environment 2007;2007(381):pe14.
2007: Sasaki Toru; Gan Eugene C; Wakeham Andrew; Kornbluth Sally; Mak Tak W; Okada Hitoshi
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
Genes & development 2007;21(7):848-61.
2007: Rueda Daniel; Gaide Olivier; Ho Liza; Lewkowicz Elodie; Niedergang Florence; Hailfinger Stephan; Rebeaud Fabien; Guzzardi Montserrat; Conne Béatrice; Thelen Marcus; Delon Jérôme; Ferch Uta; Mak Tak W; Ruland Jürgen; Schwaller Jürg; Thome Margot
Bcl10 controls TCR- and FcgammaR-induced actin polymerization.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4373-84.
2007: Suzuki A; Hamada K; Sasaki T; Mak T W; Nakano T
Role of PTEN/PI3K pathway in endothelial cells.
Biochemical Society transactions 2007;35(Pt 2):172-6.
2007: Zaugg Kathrin; Su Yu-Wen; Reilly Patrick T; Moolani Yasmin; Cheung Carol C; Hakem Razquallah; Hirao Atsushi; Liu Qinghua; Elledge Stephen J; Mak Tak W
Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3805-10.
2007: Perez G I; Acton B M; Jurisicova A; Perkins G A; White A; Brown J; Trbovich A M; Kim M-R; Fissore R; Xu J; Ahmady A; D'Estaing S G; Li H; Kagawa W; Kurumizaka H; Yokoyama S; Okada H; Mak T W; Ellisman M H; Casper R F; Tilly J L
Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure.
Cell death and differentiation 2007;14(3):524-33.
2007: Yanai Hideyuki; Chen Hui-Min; Inuzuka Takayuki; Kondo Seiji; Mak Tak W; Takaoka Akinori; Honda Kenya; Taniguchi Tadatsugu
Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3402-7.
2007: Jost Philipp J; Weiss Stephanie; Ferch Uta; Gross Olaf; Mak Tak W; Peschel Christian; Ruland Jürgen
Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):953-60.
2007: Ito Keisuke; Takubo Keiyo; Arai Fumio; Satoh Hitoshi; Matsuoka Sahoko; Ohmura Masako; Naka Kazuhito; Azuma Masaki; Miyamoto Kana; Hosokawa Kentaro; Ikeda Yasuo; Mak Tak W; Suda Toshio; Hirao Atsushi
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):103-10.
2007: Nishio Miki; Watanabe Ken-ichi; Sasaki Junko; Taya Choji; Takasuga Shunsuke; Iizuka Ryota; Balla Tamas; Yamazaki Masakazu; Watanabe Hiroshi; Itoh Reietsu; Kuroda Shoko; Horie Yasuo; Förster Irmgard; Mak Tak W; Yonekawa Hiromichi; Penninger Josef M; Kanaho Yasunori; Suzuki Akira; Sasaki Takehiko
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1.
Nature cell biology 2007;9(1):36-44.
2007: McAllister-Lucas Linda M; Ruland Jürgen; Siu Katy; Jin Xiaohong; Gu Shufang; Kim David S L; Kuffa Peter; Kohrt Dawn; Mak Tak W; Nuñez Gabriel; Lucas Peter C
CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):139-44.
2007: Klemm Stefanie; Zimmermann Stephanie; Peschel Christian; Mak Tak W; Ruland Jürgen
Bcl10 and Malt1 control lysophosphatidic acid-induced NF-kappaB activation and cytokine production.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):134-8.
2007: Berezovski Maxim V; Mak Tak W; Krylov Sergey N
Cell lysis inside the capillary facilitated by transverse diffusion of laminar flow profiles (TDLFP).
Analytical and bioanalytical chemistry 2007;387(1):91-6.
2006: Cheung Alison M; Mak Tak W
PTEN in the haematopoietic system and its therapeutic indications.
Trends in molecular medicine 2006;12(11):503-5.
2006: Clements Casey M; McNally Richard S; Conti Brian J; Mak Tak W; Ting Jenny P-Y
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15091-6.
2006: Suh Woong-Kyung; Wang Seng; Duncan Gordon S; Miyazaki Yoshiyuki; Cates Elizabeth; Walker Tina; Gajewska Beata U; Deenick Elissa; Dawicki Wojciech; Okada Hitoshi; Wakeham Andrew; Itie Annick; Watts Tania H; Ohashi Pamela S; Jordana Manel; Yoshida Hiroki; Mak Tak W
Generation and characterization of B7-H4/B7S1/B7x-deficient mice.
Molecular and cellular biology 2006;26(17):6403-11.
2006: Zhang Dong; Zaugg Kathrin; Mak Tak W; Elledge Stephen J
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.
Cell 2006;126(3):529-42.
2006: Wegener Elmar; Oeckinghaus Andrea; Papadopoulou Nikoletta; Lavitas Liron; Schmidt-Supprian Marc; Ferch Uta; Mak Tak W; Ruland Jürgen; Heissmeyer Vigo; Krappmann Daniel
Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.
Molecular cell 2006;23(1):13-23.
2006: You Han; Pellegrini Marc; Tsuchihara Katsuya; Yamamoto Kazuo; Hacker Georg; Erlacher Miriam; Villunger Andreas; Mak Tak W
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.
The Journal of experimental medicine 2006;203(7):1657-63.
2006: Plum Leona; Ma Xiaosong; Hampel Brigitte; Balthasar Nina; Coppari Roberto; Münzberg Heike; Shanabrough Marya; Burdakov Denis; Rother Eva; Janoschek Ruth; Alber Jens; Belgardt Bengt F; Koch Linda; Seibler Jost; Schwenk Frieder; Fekete Csaba; Suzuki Akira; Mak Tak W; Krone Wilhelm; Horvath Tamas L; Ashcroft Frances M; Brüning Jens C
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.
The Journal of clinical investigation 2006;116(7):1886-901.
2006: Nguyen Kinh-Tung T; Tajmir Panteha; Lin Chia Hung; Liadis Nicole; Zhu Xu-Dong; Eweida Mohammed; Tolasa-Karaman Gunce; Cai Fang; Wang Rennian; Kitamura Tadahiro; Belsham Denise D; Wheeler Michael B; Suzuki Akira; Mak Tak W; Woo Minna
Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo.
Molecular and cellular biology 2006;26(12):4511-8.
2006: Dufner Almut; Mak Tak W
CARD tricks: controlling the interactions of CARD6 with RICK and microtubules.
Cell cycle (Georgetown, Tex.) 2006;5(8):797-800.
2006: Kim R H; Mak T W
Tumours and tremors: how PTEN regulation underlies both.
British journal of cancer 2006;94(5):620-4.
2006: Cully Megan; You Han; Levine Arnold J; Mak Tak W
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.
Nature reviews. Cancer 2006;6(3):184-92.
2006: Levine Arnold J; Feng Zhaohui; Mak Tak W; You Han; Jin Shengkan
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways.
Genes & development 2006;20(3):267-75.
2006: Berger Thorsten; Togawa Atsushi; Duncan Gordon S; Elia Andrew J; You-Ten Annick; Wakeham Andrew; Fong Hannah E H; Cheung Carol C; Mak Tak W
Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1834-9.
2006: Klemm Stefanie; Gutermuth Jan; Hültner Lothar; Sparwasser Tim; Behrendt Heidrun; Peschel Christian; Mak Tak W; Jakob Thilo; Ruland Jürgen
The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation.
The Journal of experimental medicine 2006;203(2):337-47.
2006: Masumoto Junya; Yang Kangkang; Varambally Sooryanarayana; Hasegawa Mizuho; Tomlins Scott A; Qiu Su; Fujimoto Yukari; Kawasaki Akiko; Foster Simon J; Horie Yasuo; Mak Tak W; Núñez Gabriel; Chinnaiyan Arul M; Fukase Koichi; Inohara Naohiro
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo.
The Journal of experimental medicine 2006;203(1):203-13.
2006: Dufner Almut; Pownall Scott; Mak Tak W
Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):988-93.
2006: Smookler David S; Mohammed Fazilat F; Kassiri Zamaneh; Duncan Gordon S; Mak Tak W; Khokha Rama
Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):721-5.
2006: White Eric S; Atrasz Rachelle G; Hu Biao; Phan Sem H; Stambolic Vuk; Mak Tak W; Hogaboam Cory M; Flaherty Kevin R; Martinez Fernando J; Kontos Christopher D; Toews Galen B
Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10).
American journal of respiratory and critical care medicine 2006;173(1):112-21.
2005: Vidric Mariana; Suh Woong-Kyung; Dianzani Umberto; Mak Tak W; Watts Tania H
Cooperation between 4-1BB and ICOS in the immune response to influenza virus revealed by studies of CD28/ICOS-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7288-96.
2005: Cully Megan; Shiu Jessica; Piekorz Roland P; Muller William J; Done Susan J; Mak Tak W
Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis.
Cancer research 2005;65(22):10363-70.
2005: Asagiri Masataka; Sato Kojiro; Usami Takako; Ochi Sae; Nishina Hiroshi; Yoshida Hiroki; Morita Ikuo; Wagner Erwin F; Mak Tak W; Serfling Edgar; Takayanagi Hiroshi
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.
The Journal of experimental medicine 2005;202(9):1261-9.
2005: Davies Clare C; Mak Tak W; Young Lawrence S; Eliopoulos Aristides G
TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells.
Molecular and cellular biology 2005;25(22):9806-19.
2005: Berube Christina; Boucher Louis-Martin; Ma Weili; Wakeham Andrew; Salmena Leonardo; Hakem Razqallah; Yeh Wen-Chen; Mak Tak W; Benchimol Samuel
Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14314-20.
2005: Diacovo Thomas G; Blasius Amanda L; Mak Tak W; Cella Marina; Colonna Marco
Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes.
The Journal of experimental medicine 2005;202(5):687-96.
2005: Hakem Anne; Sanchez-Sweatman Otto; You-Ten Annick; Duncan Gordon; Wakeham Andrew; Khokha Rama; Mak Tak W
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis.
Genes & development 2005;19(17):1974-9.
2005: Alonso Laura; Okada Hitoshi; Pasolli Hilda Amalia; Wakeham Andrew; You-Ten Annick Itie; Mak Tak W; Fuchs Elaine
Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle.
The Journal of cell biology 2005;170(4):559-70.
2005: Chau Hien; Wong Veronica; Chen Nien-Jung; Huang Huey-Lan; Lin Wen-Jye; Mirtsos Christine; Elford Alisha R; Bonnard Madeleine; Wakeham Andrew; You-Ten Annick Itie; Lemmers Bénédicte; Salmena Leonardo; Pellegrini Marc; Hakem Razq; Mak Tak W; Ohashi Pamela; Yeh Wen-Chen
Cellular FLICE-inhibitory protein is required for T cell survival and cycling.
The Journal of experimental medicine 2005;202(3):405-13.
2005: Hao Zhenyue; Duncan Gordon S; Chang Chia-Che; Elia Andrew; Fang Min; Wakeham Andrew; Okada Hitoshi; Calzascia Thomas; Jang YingJu; You-Ten Annick; Yeh Wen-Chen; Ohashi Pamela; Wang Xiaodong; Mak Tak W
Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis.
Cell 2005;121(4):579-91.
2005: Priceputu Elena; Rodrigue Isabelle; Chrobak Pavel; Poudrier Johanne; Mak Tak W; Hanna Zaher; Hu Chunyan; Kay Denis G; Jolicoeur Paul
The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1beta-converting enzyme-deficient or Bcl2-expressing transgenic mice.
Journal of virology 2005;79(10):6377-91.
2005: Kim Raymond H; Smith Patrice D; Aleyasin Hossein; Hayley Shawn; Mount Matthew P; Pownall Scott; Wakeham Andrew; You-Ten Annick J; Kalia Suneil K; Horne Patrick; Westaway David; Lozano Andres M; Anisman Hymie; Park David S; Mak Tak W
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):5215-20.
2005: Taylor Patricia A; Panoskaltsis-Mortari Angela; Freeman Gordon J; Sharpe Arlene H; Noelle Randolph J; Rudensky Alexander Y; Mak Tak W; Serody Jonathan S; Blazar Bruce R
Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).
Blood 2005;105(8):3372-80.
2005: Kim Raymond H; Peters Malte; Jang YingJu; Shi Wei; Pintilie Melania; Fletcher Graham C; DeLuca Carmela; Liepa Jennifer; Zhou Lily; Snow Bryan; Binari Richard C; Manoukian Armen S; Bray Mark R; Liu Fei-Fei; Tsao Ming-Sound; Mak Tak W
DJ-1, a novel regulator of the tumor suppressor PTEN.
Cancer cell 2005;7(3):263-73.
2005: Gajewska Beata U; Tafuri Anna; Swirski Filip K; Walker Tina; Johnson Jill R; Shea Theresa; Shahinian Arda; Goncharova Susanna; Mak Tak W; Stämpfli Martin R; Jordana Manel
B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):3000-5.
2005: Takaoka Akinori; Yanai Hideyuki; Kondo Seiji; Duncan Gordon; Negishi Hideo; Mizutani Tatsuaki; Kano Shin-Ichi; Honda Kenya; Ohba Yusuke; Mak Tak W; Taniguchi Tadatsugu
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.
Nature 2005;434(7030):243-9.
2005: Lohoff Michael; Mak Tak W
Roles of interferon-regulatory factors in T-helper-cell differentiation.
Nature reviews. Immunology 2005;5(2):125-35.
2005: Wijesekara Nadeeja; Konrad Daniel; Eweida Mohamed; Jefferies Craig; Liadis Nicole; Giacca Adria; Crackower Mike; Suzuki Akira; Mak Tak W; Kahn C Ronald; Klip Amira; Woo Minna
Muscle-specific Pten deletion protects against insulin resistance and diabetes.
Molecular and cellular biology 2005;25(3):1135-45.
2005: White Eric S; Atrasz Rachelle G; Dickie Emily G; Aronoff David M; Stambolic Vuk; Mak Tak W; Moore Bethany B; Peters-Golden Marc
Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity.
American journal of respiratory cell and molecular biology 2005;32(2):135-41.
2005: You Han; Mak Tak W
Crosstalk between p53 and FOXO transcription factors.
Cell cycle (Georgetown, Tex.) 2005;4(1):37-8.
2004: Ito Keisuke; Hirao Atsushi; Arai Fumio; Matsuoka Sahoko; Takubo Keiyo; Hamaguchi Isao; Nomiyama Kana; Hosokawa Kentaro; Sakurada Kazuhiro; Nakagata Naomi; Ikeda Yasuo; Mak Tak W; Suda Toshio
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.
Nature 2004;431(7011):997-1002.
2004: Cully Megan; Elia Andrew; Ong Siew-Hwa; Stambolic Vuk; Pawson Tony; Tsao Ming-Sound; Mak Tak W
grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15358-63.
2004: Alstergren Per; Zhu Baoqian; Glogauer Michael; Mak Tak W; Ellen Richard P; Sodek Jaro
Polarization and directed migration of murine neutrophils is dependent on cell surface expression of CD44.
Cellular immunology 2004;231(1-2):146-57.
2004: You Han; Jang YingJu; You-Ten Annick Itie; Okada Hitoshi; Liepa Jennifer; Wakeham Andrew; Zaugg Kathrin; Mak Tak W
p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):14057-62.
2004: Blazar Bruce R; Levy Robert B; Mak Tak W; Panoskaltsis-Mortari Angela; Muta Hiromi; Jones Monica; Roskos Melinda; Serody Jonathan S; Yagita Hideo; Podack Eckhard R; Taylor Patricia A
CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):2933-41.
2004: Sakai Takashi; Liu Li; Teng Xichuan; Mukai-Sakai Rika; Shimada Hidenori; Kaji Ryuji; Mitani Tasuku; Matsumoto Mitsuru; Toida Kazunori; Ishimura Kazunori; Shishido Yuji; Mak Tak W; Fukui Kiyoshi
Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis.
The Journal of biological chemistry 2004;279(39):41131-40.
2004: Cho Dong-Hyung; Hong Yeon-Mi; Lee Ho-June; Woo Ha-Na; Pyo Jong-Ok; Mak Tak W; Jung Yong-Keun
Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein.
The Journal of biological chemistry 2004;279(38):39942-50.
2004: Suh W-K; Wang S X; Jheon A H; Moreno L; Yoshinaga S K; Ganss B; Sodek J; Grynpas M D; Mak T W
The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):12969-73.
2004: Okada Hitoshi; Mak Tak W
Pathways of apoptotic and non-apoptotic death in tumour cells.
Nature reviews. Cancer 2004;4(8):592-603.
2004: Lohoff Michael; Mittrücker Hans-Willi; Brüstle Anne; Sommer Frank; Casper Bärbel; Huber Magda; Ferrick David A; Duncan Gordon S; Mak Tak W
Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells.
The Journal of experimental medicine 2004;200(2):247-53.
2004: McPherson John Peter; Lemmers Bénédicte; Hirao Atsushi; Hakem Anne; Abraham Jacinth; Migon Eva; Matysiak-Zablocki Elzbieta; Tamblyn Laura; Sanchez-Sweatman Otto; Khokha Rama; Squire Jeremy; Hande M Prakash; Mak Tak W; Hakem Razqallah
Collaboration of Brca1 and Chk2 in tumorigenesis.
Genes & development 2004;18(10):1144-53.
2004: Suh Woong-Kyung; Tafuri Anna; Berg-Brown Nancy N; Shahinian Arda; Plyte Suzanne; Duncan Gordon S; Okada Hitoshi; Wakeham Andrew; Odermatt Bernhard; Ohashi Pamela S; Mak Tak W
The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5917-23.
2004: Trieu Young; Wen Xiao-Yan; Skinnider Brian F; Bray Mark R; Li Zhihua; Claudio Jaime O; Masih-Khan Esther; Zhu Yuan-Xiao; Trudel Suzanne; McCart J Andrea; Mak Tak W; Stewart A Keith
Soluble interleukin-13Ralpha2 decoy receptor inhibits Hodgkin's lymphoma growth in vitro and in vivo.
Cancer research 2004;64(9):3271-5.
2004: Weng Xiaoduan; Priceputu Elena; Chrobak Pavel; Poudrier Johanne; Kay Denis G; Hanna Zaher; Mak Tak W; Jolicoeur Paul
CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease.
Journal of virology 2004;78(10):5244-57.
2004: Suzuki A; Sasaki T; Mak T W; Nakano T
Functional analysis of the tumour suppressor gene PTEN in murine B cells and keratinocytes.
Biochemical Society transactions 2004;32(Pt 2):362-5.
2004: Cheung Alison M Y; Elia Andrew; Tsao Ming-Sound; Done Susan; Wagner Kay-Uwe; Hennighausen Lothar; Hakem Razqallah; Mak Tak W
Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.
Cancer research 2004;64(6):1959-65.
2004: Yamanaka Atsushi; Hamano Shinjiro; Miyazaki Yoshiyuki; Ishii Kazunari; Takeda Atsunobu; Mak Tak W; Himeno Kunisuke; Yoshimura Akihiko; Yoshida Hiroki
Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3590-6.
2004: Jiang Zhengfan; Mak Tak W; Sen Ganes; Li Xiaoxia
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3533-8.
2004: Okada Hitoshi; Bakal Chris; Shahinian Arda; Elia Andrew; Wakeham Andrew; Suh Woong-Kyung; Duncan Gordon S; Ciofani Maria; Rottapel Robert; Zúñiga-Pflücker Juan Carlos; Mak Tak W
Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death.
The Journal of experimental medicine 2004;199(3):399-410.
2004: Backman Stéphanie A; Ghazarian Danny; So Kelvin; Sanchez Otto; Wagner Kay-Uwe; Hennighausen Lothar; Suzuki Akira; Tsao Ming-Sound; Chapman William B; Stambolic Vuk; Mak Tak W
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(6):1725-30.
2004: Ho Andrew T; Li Qin H; Hakem Razqallah; Mak Tak W; Zacksenhaus Eldad
Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific.
The EMBO journal 2004;23(2):460-72.
2004: Nishitai Gen; Shimizu Nao; Negishi Takahiro; Kishimoto Hiroyuki; Nakagawa Kentaro; Kitagawa Daiju; Watanabe Tomomi; Momose Haruka; Ohata Shinya; Tanemura Shuhei; Asaka Satoshi; Kubota Junko; Saito Ryota; Yoshida Hiroki; Mak Tak W; Wada Teiji; Penninger Josef M; Azuma Noriyuki; Nishina Hiroshi; Katada Toshiaki
Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells.
The Journal of biological chemistry 2004;279(3):1621-6.
2004: Hariri Mehrdad; Wood Geoffrey A; DiGrappa Marco A; MacPherson Michelle; Backman Stephanie A; Yaffe Martin J; Mak Tak W; Boyd Norman F; Khokha Rama
Experimental manipulation of radiographic density in mouse mammary gland.
Breast cancer research : BCR 2004;6(5):R540-5.
2003: Jolicoeur Paul; Hu Chunyan; Mak Tak W; Martinou Jean-Claude; Kay Denis G
Protection against murine leukemia virus-induced spongiform myeloencephalopathy in mice overexpressing Bcl-2 but not in mice deficient for interleukin-6, inducible nitric oxide synthetase, ICE, Fas, Fas ligand, or TNF-R1 genes.
Journal of virology 2003;77(24):13161-70.
2003: Ruland Jürgen; Duncan Gordon S; Wakeham Andrew; Mak Tak W
Differential requirement for Malt1 in T and B cell antigen receptor signaling.
Immunity 2003;19(5):749-58.
2003: Hamano Shinjiro; Himeno Kunisuke; Miyazaki Yoshiyuki; Ishii Kazunari; Yamanaka Atsushi; Takeda Atsunobu; Zhang Manxin; Hisaeda Hajime; Mak Tak W; Yoshimura Akihiko; Yoshida Hiroki
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production.
Immunity 2003;19(5):657-67.
2003: Tada Yoshifumi; Koarada Syuichi; Morito Fumitaka; Ushiyama Osamu; Haruta Yoshio; Kanegae Futoshi; Ohta Akihide; Ho Alexandra; Mak Tak W; Nagasawa Kohei
Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1.
Arthritis and rheumatism 2003;48(11):3280-90.
2003: Woo Minna; Hakem Razqallah; Furlonger Caren; Hakem Anne; Duncan Gordon S; Sasaki Takehiko; Bouchard Denis; Lu Liwei; Wu Gillian E; Paige Christopher J; Mak Tak W
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.
Nature immunology 2003;4(10):1016-22.
2003: Suh Woong-Kyung; Gajewska Beata U; Okada Hitoshi; Gronski Matthew A; Bertram Edward M; Dawicki Wojciech; Duncan Gordon S; Bukczynski Jacob; Plyte Suzanne; Elia Andrew; Wakeham Andrew; Itie Annick; Chung Stephen; Da Costa Joan; Arya Sudha; Horan Tom; Campbell Pauline; Gaida Kevin; Ohashi Pamela S; Watts Tania H; Yoshinaga Steven K; Bray Mark R; Jordana Manel; Mak Tak W
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.
Nature immunology 2003;4(9):899-906.
2003: Keramaris Elizabeth; Hirao Atsushi; Slack Ruth S; Mak Tak W; Park David S
Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.
The Journal of biological chemistry 2003;278(39):37782-9.
2003: Mak Tak W; Shahinian Arda; Yoshinaga Steve K; Wakeham Andrew; Boucher Louis-Martin; Pintilie Melania; Duncan Gordon; Gajewska Beata U; Gronski Matthew; Eriksson Urs; Odermatt Bernhard; Ho Alexandra; Bouchard Denis; Whorisky John S; Jordana Manel; Ohashi Pamela S; Pawson Tony; Bladt Friedhelm; Tafuri Anna
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses.
Nature immunology 2003;4(8):765-72.
2003: Suzuki Shinobu; Suzuki Nobutaka; Mirtsos Christine; Horacek Thomas; Lye Elizabeth; Noh Seo-Kyu; Ho Alexandra; Bouchard Denis; Mak Tak W; Yeh Wen-Chen
Nur77 as a survival factor in tumor necrosis factor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8276-80.
2003: Chamaillard Mathias; Hashimoto Masahito; Horie Yasuo; Masumoto Junya; Qiu Su; Saab Lisa; Ogura Yasunori; Kawasaki Akiko; Fukase Koichi; Kusumoto Shoichi; Valvano Miguel A; Foster Simon J; Mak Tak W; Nuñez Gabriel; Inohara Naohiro
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.
Nature immunology 2003;4(7):702-7.
2003: Ruland Jürgen; Mak Tak W
From antigen to activation: specific signal transduction pathways linking antigen receptors to NF-kappaB.
Seminars in immunology 2003;15(3):177-83.
2003: Mak Tak W
'Order from disorder sprung': recognition and regulation in the immune system.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2003;361(1807):1235-50.
2003: Ruland Jürgen; Mak Tak W
Transducing signals from antigen receptors to nuclear factor kappaB.
Immunological reviews 2003;193():93-100.
2003: Takada Hidetoshi; Chen Nien-Jung; Mirtsos Christine; Suzuki Shinobu; Suzuki Nobutaka; Wakeham Andrew; Mak Tak W; Yeh Wen-Chen
Role of SODD in regulation of tumor necrosis factor responses.
Molecular and cellular biology 2003;23(11):4026-33.
2003: Takeda Atsunobu; Hamano Shinjiro; Yamanaka Atsushi; Hanada Toshikatsu; Ishibashi Tatsuro; Mak Tak W; Yoshimura Akihiko; Yoshida Hiroki
Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):4886-90.
2003: Kimura Tohru; Suzuki Akira; Fujita Yukiko; Yomogida Kentaro; Lomeli Hilda; Asada Noriko; Ikeuchi Megumi; Nagy Andras; Mak Tak W; Nakano Toru
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production.
Development (Cambridge, England) 2003;130(8):1691-700.
2003: Sarig Rachel; Zaltsman Yehudit; Marcellus Richard C; Flavell Richard; Mak Tak W; Gross Atan
BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts.
The Journal of biological chemistry 2003;278(12):10707-15.
2003: Kim Shinyop; La Motte-Mohs Ross N A; Rudolph Dorothea; Zuniga-Pflucker Juan Carlos; Mak Tak W
The role of nuclear factor-kappaB essential modulator (NEMO) in B cell development and survival.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1203-8.
2002: Takayanagi Hiroshi; Kim Sunhwa; Koga Takako; Nishina Hiroshi; Isshiki Masashi; Yoshida Hiroki; Saiura Akio; Isobe Miho; Yokochi Taeko; Inoue Jun-ichiro; Wagner Erwin F; Mak Tak W; Kodama Tatsuhiko; Taniguchi Tadatsugu
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.
Developmental cell 2002;3(6):889-901.
2002: Bertram Edward M; Tafuri Anna; Shahinian Arda; Chan Vera S F; Hunziker Lukas; Recher Mike; Ohashi Pamela S; Mak Tak W; Watts Tania H
Role of ICOS versus CD28 in antiviral immunity.
European journal of immunology 2002;32(12):3376-85.
2002: Dixit Vishva; Mak Tak W
NF-kappaB signaling. Many roads lead to madrid.
Cell 2002;111(5):615-9.
2002: Ensminger Stephan M; Spriewald Bernd M; Steger Ulrich; Morris Peter J; Mak Tak W; Wood Kathryn J
Platelet-endothelial cell adhesion molecule-1 (CD31) expression on donor endothelial cells attenuates the development of transplant arteriosclerosis.
Transplantation 2002;74(9):1267-73.
2002: Cheung Alison M Y; Hande M Prakash; Jalali Farid; Tsao Ming-Sound; Skinnider Brian; Hirao Atsushi; McPherson J Peter; Karaskova Jana; Suzuki Akira; Wakeham Andrew; You-Ten Annick; Elia Andrew; Squire Jeremy; Bristow Rob; Hakem Razqallah; Mak Tak W
Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.
Cancer research 2002;62(21):6194-204.
2002: Watanabe Tomomi; Nakagawa Kentaro; Ohata Shinya; Kitagawa Daiju; Nishitai Gen; Seo Jungwon; Tanemura Shuhei; Shimizu Nao; Kishimoto Hiroyuki; Wada Teiji; Aoki Junken; Arai Hiroyuki; Iwatsubo Takeshi; Mochita Miyuki; Watanabe Toshio; Satake Masanobu; Ito Yoshiaki; Matsuyama Toshifumi; Mak Tak W; Penninger Josef M; Nishina Hiroshi; Katada Toshiaki
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.
Developmental biology 2002;250(2):332-47.
2002: Hirao Atsushi; Cheung Alison; Duncan Gordon; Girard Pierre-Marie; Elia Andrew J; Wakeham Andrew; Okada Hitoshi; Sarkissian Talin; Wong Jorge A; Sakai Takashi; De Stanchina Elisa; Bristow Robert G; Suda Toshio; Lowe Scott W; Jeggo Penny A; Elledge Stephen J; Mak Tak W
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Molecular and cellular biology 2002;22(18):6521-32.
2002: Lohoff Michael; Mittrücker Hans-Willi; Prechtl Stefan; Bischof Susi; Sommer Frank; Kock Sonja; Ferrick David A; Duncan Gordon S; Gessner Andre; Mak Tak W
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11808-12.
2002: Mak Tak W; Yeh Wen-Chen
Immunology: a block at the toll gate.
Nature 2002;418(6900):835-6.
2002: Peters Malte; DeLuca Carmela; Hirao Atsushi; Stambolic Vuk; Potter Julia; Zhou Lily; Liepa Jennifer; Snow Bryan; Arya Sudha; Wong Jorge; Bouchard Denis; Binari Richard; Manoukian Armen S; Mak Tak W
Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11305-10.
2002: Muto Akihiro; Ruland Jürgen; McAllister-Lucas Linda M; Lucas Peter C; Yamaoka Shoji; Chen Felicia F; Lin Amy; Mak Tak W; Núñez Gabriel; Inohara Naohiro
Protein kinase C-associated kinase (PKK) mediates Bcl10-independent NF-kappa B activation induced by phorbol ester.
The Journal of biological chemistry 2002;277(35):31871-6.
2002: Jack Melissa T; Woo Richard A; Hirao Atsushi; Cheung Alison; Mak Tak W; Lee Patrick W K
Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9825-9.
2002: Skinnider Brian F; Kapp Ursula; Mak Tak W
The role of interleukin 13 in classical Hodgkin lymphoma.
Leukemia & lymphoma 2002;43(6):1203-10.
2002: Skinnider Brian F; Mak Tak W
The role of cytokines in classical Hodgkin lymphoma.
Blood 2002;99(12):4283-97.
2002: Okada Hitoshi; Suh Woong-Kyung; Jin Jianping; Woo Minna; Du Chunying; Elia Andrew; Duncan Gordon S; Wakeham Andrew; Itie Annick; Lowe Scott W; Wang Xiaodong; Mak Tak W
Generation and characterization of Smac/DIABLO-deficient mice.
Molecular and cellular biology 2002;22(10):3509-17.
2002: Weber Georg F; Bronson Roderick T; Ilagan John; Cantor Harvey; Schmits Rudolf; Mak Tak W
Absence of the CD44 gene prevents sarcoma metastasis.
Cancer research 2002;62(8):2281-6.
2002: Hitoshi Seiji; Alexson Tania; Tropepe Vincent; Donoviel Dorit; Elia Andrew J; Nye Jeffrey S; Conlon Ronald A; Mak Tak W; Bernstein Alan; van der Kooy Derek
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.
Genes & development 2002;16(7):846-58.
2002: Suzuki Nobutaka; Suzuki Shinobu; Duncan Gordon S; Millar Douglas G; Wada Teiji; Mirtsos Christine; Takada Hidetoshi; Wakeham Andrew; Itie Annick; Li Shyun; Penninger Josef M; Wesche Holger; Ohashi Pamela S; Mak Tak W; Yeh Wen-Chen
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.
Nature 2002;416(6882):750-6.
2002: Tang Damu; Wu Dongcheng; Hirao Atsushi; Lahti Jill M; Liu Lieqi; Mazza Brie; Kidd Vincent J; Mak Tak W; Ingram Alistair J
ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.
The Journal of biological chemistry 2002;277(15):12710-7.
2002: Hara Hiromitsu; Takeda Atsunobu; Takeuchi Michiyo; Wakeham Andrew C; Itié Annick; Sasaki Masafumi; Mak Tak W; Yoshimura Akihiko; Nomoto Kikuo; Yoshida Hiroki
The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2288-95.
2002: Skinnider Brian F; Elia Andrew J; Gascoyne Randy D; Patterson Bruce; Trumper Lorenz; Kapp Ursula; Mak Tak W
Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.
Blood 2002;99(2):618-26.
2002: Mak Tak W; Yeh Wen-Chen
Signaling for survival and apoptosis in the immune system.
Arthritis research 2002;4 Suppl 3():S243-52.
2001: Skinnider B F; Kapp U; Mak T W
Interleukin 13: a growth factor in hodgkin lymphoma.
International archives of allergy and immunology 2001;126(4):267-76.
2001: Backman S A; Stambolic V; Suzuki A; Haight J; Elia A; Pretorius J; Tsao M S; Shannon P; Bolon B; Ivy G O; Mak T W
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.
Nature genetics 2001;29(4):396-403.
2001: Sasaki T; Wada T; Kishimoto H; Irie-Sasaki J; Matsumoto G; Goto T; Yao Z; Wakeham A; Mak T W; Suzuki A; Cho S K; Zuniga-Pflucker J C; Oliveira-dos-Santos A J; Katada T; Nishina H; Penninger J M
The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.
The Journal of experimental medicine 2001;194(6):757-68.
2001: Leco K J; Waterhouse P; Sanchez O H; Gowing K L; Poole A R; Wakeham A; Mak T W; Khokha R
Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3).
The Journal of clinical investigation 2001;108(6):817-29.
2001: Tang D; Okada H; Ruland J; Liu L; Stambolic V; Mak T W; Ingram A J
Akt is activated in response to an apoptotic signal.
The Journal of biological chemistry 2001;276(32):30461-6.
2001: McAllister-Lucas L M; Inohara N; Lucas P C; Ruland J; Benito A; Li Q; Chen S; Chen F F; Yamaoka S; Verma I M; Mak T W; Núñez G
Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction.
The Journal of biological chemistry 2001;276(33):30589-97.
2001: Schimmer A D; Hedley D W; Chow S; Pham N A; Chakrabartty A; Bouchard D; Mak T W; Trus M R; Minden M D
The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2.
Cell death and differentiation 2001;8(7):725-33.
2001: Miyazaki K; Yoshida H; Sasaki M; Hara H; Kimura G; Mak T W; Nomoto K
Caspase-independent cell death and mitochondrial disruptions observed in the Apaf1-deficient cells.
Journal of biochemistry 2001;129(6):963-9.
2001: Suzuki A; Yamaguchi M T; Ohteki T; Sasaki T; Kaisho T; Kimura Y; Yoshida R; Wakeham A; Higuchi T; Fukumoto M; Tsubata T; Ohashi P S; Koyasu S; Penninger J M; Nakano T; Mak T W
T cell-specific loss of Pten leads to defects in central and peripheral tolerance.
Immunity 2001;14(5):523-34.
2001: Tropepe V; Hitoshi S; Sirard C; Mak T W; Rossant J; van der Kooy D
Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism.
Neuron 2001;30(1):65-78.
2001: Okkenhaug K; Wu L; Garza K M; La Rose J; Khoo W; Odermatt B; Mak T W; Ohashi P S; Rottapel R
A point mutation in CD28 distinguishes proliferative signals from survival signals.
Nature immunology 2001;2(4):325-32.
2001: Joza N; Susin S A; Daugas E; Stanford W L; Cho S K; Li C Y; Sasaki T; Elia A J; Cheng H Y; Ravagnan L; Ferri K F; Zamzami N; Wakeham A; Hakem R; Yoshida H; Kong Y Y; Mak T W; Zúñiga-Pflücker J C; Kroemer G; Penninger J M
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death.
Nature 2001;410(6828):549-54.
2001: Sommer F; Faller G; Röllinghoff M; Kirchner T; Mak T W; Lohoff M
Lack of gastritis and of an adaptive immune response in interferon regulatory factor-1-deficient mice infected with Helicobacter pylori.
European journal of immunology 2001;31(2):396-402.
2001: Ruland J; Sirard C; Elia A; MacPherson D; Wakeham A; Li L; de la Pompa J L; Cohen S N; Mak T W
p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1859-64.
2001: Tafuri A; Shahinian A; Bladt F; Yoshinaga S K; Jordana M; Wakeham A; Boucher L M; Bouchard D; Chan V S; Duncan G; Odermatt B; Ho A; Itie A; Horan T; Whoriskey J S; Pawson T; Penninger J M; Ohashi P S; Mak T W
ICOS is essential for effective T-helper-cell responses.
Nature 2001;409(6816):105-9.
2001: Ruland J; Duncan G S; Elia A; del Barco Barrantes I; Nguyen L; Plyte S; Millar D G; Bouchard D; Wakeham A; Ohashi P S; Mak T W
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.
Cell 2001;104(1):33-42.
2001: Skinnider B F; Elia A J; Gascoyne R D; Trümper L H; von Bonin F; Kapp U; Patterson B; Snow B E; Mak T W
Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.
Blood 2001;97(1):250-5.
2000: Woo M; Hakem R; Mak T W
Executionary pathway for apoptosis: lessons from mutant mice.
Cell research 2000;10(4):267-78.
2000: Wang B; Fujisawa H; Zhuang L; Freed I; Howell B G; Shahid S; Shivji G M; Mak T W; Sauder D N
CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6783-90.
2000: Boehmelt G; Wakeham A; Elia A; Sasaki T; Plyte S; Potter J; Yang Y; Tsang E; Ruland J; Iscove N N; Dennis J W; Mak T W
Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells.
The EMBO journal 2000;19(19):5092-104.
2000: Lomaga M A; Henderson J T; Elia A J; Robertson J; Noyce R S; Yeh W C; Mak T W
Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(19):7384-93.
2000: Bonnard M; Mirtsos C; Suzuki S; Graham K; Huang J; Ng M; Itié A; Wakeham A; Shahinian A; Henzel W J; Elia A J; Shillinglaw W; Mak T W; Cao Z; Yeh W C
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.
The EMBO journal 2000;19(18):4976-85.
2000: Sasaki T; Irie-Sasaki J; Horie Y; Bachmaier K; Fata J E; Li M; Suzuki A; Bouchard D; Ho A; Redston M; Gallinger S; Khokha R; Mak T W; Hawkins P T; Stephens L; Scherer S W; Tsao M; Penninger J M
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.
Nature 2000;406(6798):897-902.
2000: Scanga S E; Ruel L; Binari R C; Snow B; Stambolic V; Bouchard D; Peters M; Calvieri B; Mak T W; Woodgett J R; Manoukian A S
The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila.
Oncogene 2000;19(35):3971-7.
2000: Susin S A; Daugas E; Ravagnan L; Samejima K; Zamzami N; Loeffler M; Costantini P; Ferri K F; Irinopoulou T; Prévost M C; Brothers G; Mak T W; Penninger J; Earnshaw W C; Kroemer G
Two distinct pathways leading to nuclear apoptosis.
The Journal of experimental medicine 2000;192(4):571-80.
2000: Lohoff M; Duncan G S; Ferrick D; Mittrücker H W; Bischof S; Prechtl S; Röllinghoff M; Schmitt E; Pahl A; Mak T W
Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells.
The Journal of experimental medicine 2000;192(3):325-36.
2000: Stambolic V; Tsao M S; Macpherson D; Suzuki A; Chapman W B; Mak T W
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.
Cancer research 2000;60(13):3605-11.
2000: Mak T W; Hakem A; McPherson J P; Shehabeldin A; Zablocki E; Migon E; Duncan G S; Bouchard D; Wakeham A; Cheung A; Karaskova J; Sarosi I; Squire J; Marth J; Hakem R
Brcal required for T cell lineage development but not TCR loci rearrangement.
Nature immunology 2000;1(1):77-82.
2000: Yeh W C; Itie A; Elia A J; Ng M; Shu H B; Wakeham A; Mirtsos C; Suzuki N; Bonnard M; Goeddel D V; Mak T W
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.
Immunity 2000;12(6):633-42.
2000: Boehmelt G; Fialka I; Brothers G; McGinley M D; Patterson S D; Mo R; Hui C C; Chung S; Huber L A; Mak T W; Iscove N N
Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association.
The Journal of biological chemistry 2000;275(17):12821-32.
2000: Rudolph D; Yeh W C; Wakeham A; Rudolph B; Nallainathan D; Potter J; Elia A J; Mak T W
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.
Genes & development 2000;14(7):854-62.
2000: Hirao A; Kong Y Y; Matsuoka S; Wakeham A; Ruland J; Yoshida H; Liu D; Elledge S J; Mak T W
DNA damage-induced activation of p53 by the checkpoint kinase Chk2.
Science (New York, N.Y.) 2000;287(5459):1824-7.
2000: Nguyen L T; McKall-Faienza K; Zakarian A; Speiser D E; Mak T W; Ohashi P S
TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions.
European journal of immunology 2000;30(2):683-8.
2000: Sasaki T; Irie-Sasaki J; Jones R G; Oliveira-dos-Santos A J; Stanford W L; Bolon B; Wakeham A; Itie A; Bouchard D; Kozieradzki I; Joza N; Mak T W; Ohashi P S; Suzuki A; Penninger J M
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
Science (New York, N.Y.) 2000;287(5455):1040-6.
2000: Sirard C; Kim S; Mirtsos C; Tadich P; Hoodless P A; Itié A; Maxson R; Wrana J L; Mak T W
Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.
The Journal of biological chemistry 2000;275(3):2063-70.
1999: Yoshinaga S K; Whoriskey J S; Khare S D; Sarmiento U; Guo J; Horan T; Shih G; Zhang M; Coccia M A; Kohno T; Tafuri-Bladt A; Brankow D; Campbell P; Chang D; Chiu L; Dai T; Duncan G; Elliott G S; Hui A; McCabe S M; Scully S; Shahinian A; Shaklee C L; Van G; Mak T W; Senaldi G
T-cell co-stimulation through B7RP-1 and ICOS.
Nature 1999;402(6763):827-32.
1999: Senaldi G; Shaklee C L; Guo J; Martin L; Boone T; Mak T W; Ulich T R
Protection against the mortality associated with disease models mediated by TNF and IFN-gamma in mice lacking IFN regulatory factor-1.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6820-6.
1999: Stambolic V; Mak T W; Woodgett J R
Modulation of cellular apoptotic potential: contributions to oncogenesis.
Oncogene 1999;18(45):6094-103.
1999: Woo M; Hakem A; Elia A J; Hakem R; Duncan G S; Patterson B J; Mak T W
In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4909-16.
1999: Hoeflich K P; Yeh W C; Yao Z; Mak T W; Woodgett J R
Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1).
Oncogene 1999;18(42):5814-20.
1999: Nguyen L T; Duncan G S; Mirtsos C; Ng M; Speiser D E; Shahinian A; Marino M W; Mak T W; Ohashi P S; Yeh W C
TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.
Immunity 1999;11(3):379-89.
1999: Bachmann M F; Speiser D E; Mak T W; Ohashi P S
Absence of co-stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo.
European journal of immunology 1999;29(7):2156-66.
1999: Yeh W C; Hakem R; Woo M; Mak T W
Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling.
Immunological reviews 1999;169():283-302.
1999: Kapp U; Yeh W C; Patterson B; Elia A J; Kägi D; Ho A; Hessel A; Tipsword M; Williams A; Mirtsos C; Itie A; Moyle M; Mak T W
Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells.
The Journal of experimental medicine 1999;189(12):1939-46.
1999: Barrantes I B; Elia A J; Wünsch K; Hrabe de Angelis M H; Mak T W; Rossant J; Conlon R A; Gossler A; de la Pompa J L
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse.
Current biology : CB 1999;9(9):470-80.
1999: Senaldi G; Shaklee C L; Mak T W; Ulich T R
Corynebacterium parvum- and Mycobacterium bovis Bacillus Calmette and Guerin-induced granuloma formation in mice lacking CD4 and CD8.
Cellular immunology 1999;193(2):155-61.
1999: Lomaga M A; Yeh W C; Sarosi I; Duncan G S; Furlonger C; Ho A; Morony S; Capparelli C; Van G; Kaufman S; van der Heiden A; Itie A; Wakeham A; Khoo W; Sasaki T; Cao Z; Penninger J M; Paige C J; Lacey D L; Dunstan C R; Boyle W J; Goeddel D V; Mak T W
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Genes & development 1999;13(8):1015-24.
1999: Kägi D; Ho A; Odermatt B; Zakarian A; Ohashi P S; Mak T W
TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4598-605.
1999: Oliveira-dos-Santos A J; Ho A; Tada Y; Lafaille J J; Tonegawa S; Mak T W; Penninger J M
CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4490-5.
1999: Ohteki T; Maki C; Koyasu S; Mak T W; Ohashi P S
Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):3753-6.
1999: Bachmaier K; Neu N; Yeung R S; Mak T W; Liu P; Penninger J M
Generation of humanized mice susceptible to peptide-induced inflammatory heart disease.
Circulation 1999;99(14):1885-91.
1999: Soengas M S; Alarcón R M; Yoshida H; Giaccia A J; Hakem R; Mak T W; Lowe S W
Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.
Science (New York, N.Y.) 1999;284(5411):156-9.
1999: Duncan G S; Andrew D P; Takimoto H; Kaufman S A; Yoshida H; Spellberg J; Luis de la Pompa J; Elia A; Wakeham A; Karan-Tamir B; Muller W A; Senaldi G; Zukowski M M; Mak T W
Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):3022-30.
1999: Zhuang L; Wang B; Shinder G A; Shivji G M; Mak T W; Sauder D N
TNF receptor p55 plays a pivotal role in murine keratinocyte apoptosis induced by ultraviolet B irradiation.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1440-7.
1999: Kong Y Y; Yoshida H; Sarosi I; Tan H L; Timms E; Capparelli C; Morony S; Oliveira-dos-Santos A J; Van G; Itie A; Khoo W; Wakeham A; Dunstan C R; Lacey D L; Mak T W; Boyle W J; Penninger J M
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.
Nature 1999;397(6717):315-23.
1999: Mak T W; Yeh W C
Genetic analysis of apoptotic and survival signals.
Cold Spring Harbor symposia on quantitative biology 1999;64():335-42.
1998: Fujii H; Ogasawara K; Otsuka H; Suzuki M; Yamamura K; Yokochi T; Miyazaki T; Suzuki H; Mak T W; Taki S; Taniguchi T
Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations.
The EMBO journal 1998;17(22):6551-7.
1998: Hakem R; de la Pompa J L; Mak T W
Developmental studies of Brca1 and Brca2 knock-out mice.
Journal of mammary gland biology and neoplasia 1998;3(4):431-45.
1998: Penninger J M; Mak T W
Thymocyte selection in Vav and IRF-1 gene-deficient mice.
Immunological reviews 1998;165():149-66.
1998: Suzuki A; de la Pompa J L; Stambolic V; Elia A J; Sasaki T; del Barco Barrantes I; Ho A; Wakeham A; Itie A; Khoo W; Fukumoto M; Mak T W
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
Current biology : CB 1998;8(21):1169-78.
1998: Stambolic V; Suzuki A; de la Pompa J L; Brothers G M; Mirtsos C; Sasaki T; Ruland J; Penninger J M; Siderovski D P; Mak T W
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.
Cell 1998;95(1):29-39.
1998: Yoshida H; Kong Y Y; Yoshida R; Elia A J; Hakem A; Hakem R; Penninger J M; Mak T W
Apaf1 is required for mitochondrial pathways of apoptosis and brain development.
Cell 1998;94(6):739-50.
1998: Boyd R; Kozieradzki I; Chidgey A; Mittrücker H W; Bouchard D; Timms E; Kishihara K; Ong C J; Chui D; Marth J D; Mak T W; Penninger J M
Receptor-specific allelic exclusion of TCRV alpha-chains during development.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1718-27.
1998: Hakem R; Hakem A; Duncan G S; Henderson J T; Woo M; Soengas M S; Elia A; de la Pompa J L; Kagi D; Khoo W; Potter J; Yoshida R; Kaufman S A; Lowe S W; Penninger J M; Mak T W
Differential requirement for caspase 9 in apoptotic pathways in vivo.
Cell 1998;94(3):339-52.
1998: Huber M; Timms E; Mak T W; Röllinghoff M; Lohoff M
Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice.
Infection and immunity 1998;66(8):3968-70.
1998: Andrew D P; Spellberg J P; Takimoto H; Schmits R; Mak T W; Zukowski M M
Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice.
European journal of immunology 1998;28(6):1959-69.
1998: Saoulli K; Lee S Y; Cannons J L; Yeh W C; Santana A; Goldstein M D; Bangia N; DeBenedette M A; Mak T W; Choi Y; Watts T H
CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.
The Journal of experimental medicine 1998;187(11):1849-62.
1998: Wen T; Trümper L; Fung-Leung W; Rahemtulla A; Klein E; Klein G; Mak T W
Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts.
Immunology letters 1998;61(2-3):187-90.
1998: McKall-Faienza K J; Kawai K; Kündig T M; Odermatt B; Bachmann M F; Zakarian A; Mak T W; Ohashi P S
Absence of TNFRp55 influences virus-induced autoimmunity despite efficient lymphocytic infiltration.
International immunology 1998;10(4):405-12.
1998: de la Pompa J L; Timmerman L A; Takimoto H; Yoshida H; Elia A J; Samper E; Potter J; Wakeham A; Marengere L; Langille B L; Crabtree G R; Mak T W
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum.
Nature 1998;392(6672):182-6.
1998: Woo M; Hakem R; Soengas M S; Duncan G S; Shahinian A; Kägi D; Hakem A; McCurrach M; Khoo W; Kaufman S A; Senaldi G; Howard T; Lowe S W; Mak T W
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes.
Genes & development 1998;12(6):806-19.
1998: Yeh W C; Pompa J L; McCurrach M E; Shu H B; Elia A J; Shahinian A; Ng M; Wakeham A; Khoo W; Mitchell K; El-Deiry W S; Lowe S W; Goeddel D V; Mak T W
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.
Science (New York, N.Y.) 1998;279(5358):1954-8.
1998: Bachmann M F; Waterhouse P; Speiser D E; McKall-Faienza K; Mak T W; Ohashi P S
Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):95-100.
1998: Yoshida H; Nishina H; Takimoto H; Marengère L E; Wakeham A C; Bouchard D; Kong Y Y; Ohteki T; Shahinian A; Bachmann M; Ohashi P S; Penninger J M; Crabtree G R; Mak T W
The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.
Immunity 1998;8(1):115-24.
1998: Sirard C; de la Pompa J L; Elia A; Itie A; Mirtsos C; Cheung A; Hahn S; Wakeham A; Schwartz L; Kern S E; Rossant J; Mak T W
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.
Genes & development 1998;12(1):107-19.
1997: Wang B; Fujisawa H; Zhuang L; Kondo S; Shivji G M; Kim C S; Mak T W; Sauder D N
Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6148-55.
1997: Ohteki T; Ho S; Suzuki H; Mak T W; Ohashi P S
Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5931-5.
1997: Yeh W C; Shahinian A; Speiser D; Kraunus J; Billia F; Wakeham A; de la Pompa J L; Ferrick D; Hum B; Iscove N; Ohashi P; Rothe M; Goeddel D V; Mak T W
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.
Immunity 1997;7(5):715-25.
1997: Bachmann M F; McKall-Faienza K; Schmits R; Bouchard D; Beach J; Speiser D E; Mak T W; Ohashi P S
Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation.
Immunity 1997;7(4):549-57.
1997: Marengère L E; Okkenhaug K; Clavreul A; Couez D; Gibson S; Mills G B; Mak T W; Rottapel R
The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3220-9.
1997: Schmits R; Filmus J; Gerwin N; Senaldi G; Kiefer F; Kundig T; Wakeham A; Shahinian A; Catzavelos C; Rak J; Furlonger C; Zakarian A; Simard J J; Ohashi P S; Paige C J; Gutierrez-Ramos J C; Mak T W
CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity.
Blood 1997;90(6):2217-33.
1997: Nishina H; Bachmann M; Oliveira-dos-Santos A J; Kozieradzki I; Fischer K D; Odermatt B; Wakeham A; Shahinian A; Takimoto H; Bernstein A; Mak T W; Woodgett J R; Ohashi P S; Penninger J M
Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.
The Journal of experimental medicine 1997;186(6):941-53.
1997: Reitmair A H; Risley R; Bristow R G; Wilson T; Ganesh A; Jang A; Peacock J; Benchimol S; Hill R P; Mak T W; Fishel R; Meuth M
Mutator phenotype in Msh2-deficient murine embryonic fibroblasts.
Cancer research 1997;57(17):3765-71.
1997: Waterhouse P; Bachmann M F; Penninger J M; Ohashi P S; Mak T W
Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice.
European journal of immunology 1997;27(8):1887-92.
1997: Penninger J M; Sirard C; Mittrücker H W; Chidgey A; Kozieradzki I; Nghiem M; Hakem A; Kimura T; Timms E; Boyd R; Taniguchi T; Matsuyama T; Mak T W
The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.
Immunity 1997;7(2):243-54.
1997: Bachmaier K; Neu N; Pummerer C; Duncan G S; Mak T W; Matsuyama T; Penninger J M
iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1.
Circulation 1997;96(2):585-91.
1997: Hakem R; de la Pompa J L; Elia A; Potter J; Mak T W
Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.
Nature genetics 1997;16(3):298-302.
1997: Marengère L E; Mirtsos C; Kozieradzki I; Veillette A; Mak T W; Penninger J M
Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):70-6.
1997: Lohoff M; Ferrick D; Mittrucker H W; Duncan G S; Bischof S; Rollinghoff M; Mak T W
Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo.
Immunity 1997;6(6):681-9.
1997: Speiser D E; Bachmann M F; Frick T W; McKall-Faienza K; Griffiths E; Pfeffer K; Mak T W; Ohashi P S
TNF receptor p55 controls early acute graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5185-90.
1997: Sebzda E; Choi M; Fung-Leung W P; Mak T W; Ohashi P S
Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.
Immunity 1997;6(5):643-53.
1997: Suzuki A; de la Pompa J L; Hakem R; Elia A; Yoshida R; Mo R; Nishina H; Chuang T; Wakeham A; Itie A; Koo W; Billia P; Ho A; Fukumoto M; Hui C C; Mak T W
Brca2 is required for embryonic cellular proliferation in the mouse.
Genes & development 1997;11(10):1242-52.
1997: Tamura T; Ishihara M; Lamphier M S; Tanaka N; Oishi I; Aizawa S; Matsuyama T; Mak T W; Taki S; Taniguchi T
DNA damage-induced apoptosis and Ice gene induction in mitogenically activated T lymphocytes require IRF-1.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11 Suppl 3():439-40.
1997: Boucher L M; Marengère L E; Lu Y; Thukral S; Mak T W
Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.
Biochemical and biophysical research communications 1997;233(3):592-600.
1997: Wallace V A; Penninger J M; Kishihara K; Timms E; Shahinian A; Pircher H; Kündig T M; Ohashi P S; Mak T W
Alterations in the level of CD45 surface expression affect the outcome of thymic selection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3205-14.
1997: Kozieradzki I; Kündig T; Kishihara K; Ong C J; Chiu D; Wallace V A; Kawai K; Timms E; Ionescu J; Ohashi P; Marth J D; Mak T W; Penninger J M
T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3130-9.
1997: Lowsky R; DeCoteau J F; Reitmair A H; Ichinohasama R; Dong W F; Xu Y; Mak T W; Kadin M E; Minden M D
Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL).
Blood 1997;89(7):2276-82.
1997: Speiser D E; Bachmann M F; Shahinian A; Mak T W; Ohashi P S
Acute graft-versus-host disease without costimulation via CD28.
Transplantation 1997;63(7):1042-4.
1997: Suzuki H; Duncan G S; Takimoto H; Mak T W
Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain.
The Journal of experimental medicine 1997;185(3):499-505.
1997: Bachmaier K; Pummerer C; Kozieradzki I; Pfeffer K; Mak T W; Neu N; Penninger J M
Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease.
Circulation 1997;95(3):655-61.
1997: Tada Y; Ho A; Matsuyama T; Mak T W
Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1.
The Journal of experimental medicine 1997;185(2):231-8.
1997: Bachmann M F; Kündig T M; Speiser D E; McKall-Faienza K; Kishara K; Mak T W; Ohashi P S
T-cell-independent antiviral B cell responses in CD45-deficient mice.
Cellular immunology 1997;175(1):12-5.
1997: Nishina H; Fischer K D; Radvanyi L; Shahinian A; Hakem R; Rubie E A; Bernstein A; Mak T W; Woodgett J R; Penninger J M
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3.
Nature 1997;385(6614):350-3.
1997: Mittrücker H W; Matsuyama T; Grossman A; Kündig T M; Potter J; Shahinian A; Wakeham A; Patterson B; Ohashi P S; Mak T W
Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.
Science (New York, N.Y.) 1997;275(5299):540-3.
1997: DeBenedette M A; Shahinian A; Mak T W; Watts T H
Costimulation of CD28- T lymphocytes by 4-1BB ligand.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):551-9.
1996: Speiser D E; Sebzda E; Ohteki T; Bachmann M F; Pfeffer K; Mak T W; Ohashi P S
Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo.
European journal of immunology 1996;26(12):3055-60.
1996: Penninger J M; Wallace V A; Molina T; Mak T W
Lineage-specific control of superantigen-induced cell death by the protein tyrosine kinase p56(lck).
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5359-66.
1996: Senaldi G; Yin S; Shaklee C L; Piguet P F; Mak T W; Ulich T R
Corynebacterium parvum- and Mycobacterium bovis bacillus Calmette-Guerin-induced granuloma formation is inhibited in TNF receptor I (TNF-RI) knockout mice and by treatment with soluble TNF-RI.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5022-6.
1996: Duncan G S; Mittrücker H W; Kägi D; Matsuyama T; Mak T W
The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo.
The Journal of experimental medicine 1996;184(5):2043-8.
1996: Waterhouse P; Marengère L E; Mittrücker H W; Mak T W
CTLA-4, a negative regulator of T-lymphocyte activation.
Immunological reviews 1996;153():183-207.
1996: Grossman A; Mittrücker H W; Nicholl J; Suzuki A; Chung S; Antonio L; Suggs S; Sutherland G R; Siderovski D P; Mak T W
Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25.
Genomics 1996;37(2):229-33.
1996: Bachmann M F; Sebzda E; Kündig T M; Shahinian A; Speiser D E; Mak T W; Ohashi P S
T cell responses are governed by avidity and co-stimulatory thresholds.
European journal of immunology 1996;26(9):2017-22.
1996: Bachmaier K; Pummerer C; Shahinian A; Ionescu J; Neu N; Mak T W; Penninger J M
Induction of autoimmunity in the absence of CD28 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1752-7.
1996: Tanaka N; Ishihara M; Lamphier M S; Nozawa H; Matsuyama T; Mak T W; Aizawa S; Tokino T; Oren M; Taniguchi T
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage.
Nature 1996;382(6594):816-8.
1996: Reitmair A H; Redston M; Cai J C; Chuang T C; Bjerknes M; Cheng H; Hay K; Gallinger S; Bapat B; Mak T W
Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.
Cancer research 1996;56(16):3842-9.
1996: Kündig T M; Shahinian A; Kawai K; Mittrücker H W; Sebzda E; Bachmann M F; Mak T W; Ohashi P S
Duration of TCR stimulation determines costimulatory requirement of T cells.
Immunity 1996;5(1):41-52.
1996: Reitmair A H; Cai J C; Bjerknes M; Redston M; Cheng H; Pind M T; Hay K; Mitri A; Bapat B V; Mak T W; Gallinger S
MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis.
Cancer research 1996;56(13):2922-6.
1996: Wang B; Kondo S; Shivji G M; Fujisawa H; Mak T W; Sauder D N
Tumour necrosis factor receptor II (p75) signalling is required for the migration of Langerhans' cells.
Immunology 1996;88(2):284-8.
1996: Mittrücker H W; Shahinian A; Bouchard D; Kündig T M; Mak T W
Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice.
The Journal of experimental medicine 1996;183(6):2481-8.
1996: Hakem R; de la Pompa J L; Sirard C; Mo R; Woo M; Hakem A; Wakeham A; Potter J; Reitmair A; Billia F; Firpo E; Hui C C; Roberts J; Rossant J; Mak T W
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
Cell 1996;85(7):1009-23.
1996: Yeung R S; Penninger J M; Kündig T; Khoo W; Ohashi P S; Kroemer G; Mak T W
Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen-induced septic shock.
European journal of immunology 1996;26(5):1074-82.
1996: Marengère L E; Waterhouse P; Duncan G S; Mittrücker H W; Feng G S; Mak T W
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.
Science (New York, N.Y.) 1996;272(5265):1170-3.
1996: Kondo S; Beissert S; Wang B; Fujisawa H; Kooshesh F; Stratigos A; Granstein R D; Mak T W; Sauder D N
Hyporesponsiveness in contact hypersensitivity and irritant contact dermatitis in CD4 gene targeted mouse.
The Journal of investigative dermatology 1996;106(5):993-1000.
1996: Suzuki A; Andrew D P; Gonzalo J A; Fukumoto M; Spellberg J; Hashiyama M; Takimoto H; Gerwin N; Webb I; Molineux G; Amakawa R; Tada Y; Wakeham A; Brown J; McNiece I; Ley K; Butcher E C; Suda T; Gutierrez-Ramos J C; Mak T W
CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein.
Blood 1996;87(9):3550-62.
1996: Schmits R; Kündig T M; Baker D M; Shumaker G; Simard J J; Duncan G; Wakeham A; Shahinian A; van der Heiden A; Bachmann M F; Ohashi P S; Mak T W; Hickstein D D
LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.
The Journal of experimental medicine 1996;183(4):1415-26.
1996: Kawai K; Shahinian A; Mak T W; Ohashi P S
Skin allograft rejection in CD28-deficient mice.
Transplantation 1996;61(3):352-5.
1996: Amakawa R; Hakem A; Kundig T M; Matsuyama T; Simard J J; Timms E; Wakeham A; Mittruecker H W; Griesser H; Takimoto H; Schmits R; Shahinian A; Ohashi P; Penninger J M; Mak T W
Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice.
Cell 1996;84(4):551-62.
1996: Kimura T; Kadokawa Y; Harada H; Matsumoto M; Sato M; Kashiwazaki Y; Tarutani M; Tan R S; Takasugi T; Matsuyama T; Mak T W; Noguchi S; Taniguchi T
Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(1):115-24.
1996: Benatar T; Carsetti R; Furlonger C; Kamalia N; Mak T; Paige C J
Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.
The Journal of experimental medicine 1996;183(1):329-34.
1995: Mittrücker H W; Pfeffer K; Schmits R; Mak T W
T-lymphocyte development and function in gene-targeted mutant mice.
Immunological reviews 1995;148():115-50.
1995: Mak T W
Funding, education, and training in the context of industry-academia relations.
The American journal of medicine 1995;99(6A):84S-86S.
1995: Wen T; Zhang L; Kung S K; Molina T J; Miller R G; Mak T W
Allo-skin graft rejection, tumor rejection and natural killer activity in mice lacking p56lck.
European journal of immunology 1995;25(11):3155-9.
1995: Waterhouse P; Penninger J M; Timms E; Wakeham A; Shahinian A; Lee K P; Thompson C B; Griesser H; Mak T W
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.
Science (New York, N.Y.) 1995;270(5238):985-8.
1995: Oka C; Nakano T; Wakeham A; de la Pompa J L; Mori C; Sakai T; Okazaki S; Kawaichi M; Shiota K; Mak T W; Honjo T
Disruption of the mouse RBP-J kappa gene results in early embryonic death.
Development (Cambridge, England) 1995;121(10):3291-301.
1995: Penninger J M; Timms E; Shahinian A; Jezo-Bremond A; Nishina H; Ionescu J; Hedrick S M; Mak T W
Alloreactive gamma delta thymocytes utilize distinct costimulatory signals from peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3847-55.
1995: Kondo S; Wang B; Fujisawa H; Shivji G M; Echtenacher B; Mak T W; Sauder D N
Effect of gene-targeted mutation in TNF receptor (p55) on contact hypersensitivity and ultraviolet B-induced immunosuppression.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3801-5.
1995: Koh D R; Ho A; Rahemtulla A; Fung-Leung W P; Griesser H; Mak T W
Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells.
European journal of immunology 1995;25(9):2558-62.
1995: Wu H K; Heng H H; Shi X M; Forsdyke D R; Tsui L C; Mak T W; Minden M D; Siderovski D P
Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(8):1291-8.
1995: Tamura T; Ishihara M; Lamphier M S; Tanaka N; Oishi I; Aizawa S; Matsuyama T; Mak T W; Taki S; Taniguchi T
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes.
Nature 1995;376(6541):596-9.
1995: Penninger J M; Schilham M W; Timms E; Wallace V A; Mak T W
T cell repertoire and clonal deletion of Mtv superantigen-reactive T cells in mice lacking CD4 and CD8 molecules.
European journal of immunology 1995;25(7):2115-8.
1995: Matsuyama T; Grossman A; Mittrücker H W; Siderovski D P; Kiefer F; Kawakami T; Richardson C D; Taniguchi T; Yoshinaga S K; Mak T W
Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE).
Nucleic acids research 1995;23(12):2127-36.
1995: Penninger J M; Wen T; Timms E; Potter J; Wallace V A; Matsuyama T; Ferrick D; Sydora B; Kronenberg M; Mak T W
Spontaneous resistance to acute T-cell leukaemias in TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice.
Nature 1995;375(6528):241-4.
1995: Kawai K; Kishihara K; Molina T J; Wallace V A; Mak T W; Ohashi P S
Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice.
The Journal of experimental medicine 1995;181(1):345-9.
1995: Fung-Leung W P; Kishihara K; Gray D; Teh H S; Lau C Y; Mak T W
Intestinal T cells in CD8 alpha knockout mice and T cell receptor transgenic mice.
Advances in experimental medicine and biology 1995;371A():121-4.
1994: Penninger J M; Mak T W
Signal transduction, mitotic catastrophes, and death in T-cell development.
Immunological reviews 1994;142():231-72.
1994: Yeung R S; Penninger J M; Kündig T M; Law Y; Yamamoto K; Kamikawaji N; Burkly L; Sasazuki T; Flavell R; Ohashi P S; Mak T W
Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.
The Journal of experimental medicine 1994;180(5):1911-20.
1994: Fung-Leung W P; Kündig T M; Ngo K; Panakos J; De Sousa-Hitzler J; Wang E; Ohashi P S; Mak T W; Lau C Y
Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.
The Journal of experimental medicine 1994;180(3):959-67.
1994: Koh D R; Ho A; Rahemtulla A; Penninger J; Mak T W
Experimental allergic encephalomyelitis (EAE) in mice lacking CD4+ T cells.
European journal of immunology 1994;24(9):2250-3.
1994: Rahemtulla A; Kündig T M; Narendran A; Bachmann M F; Julius M; Paige C J; Ohashi P S; Zinkernagel R M; Mak T W
Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice.
European journal of immunology 1994;24(9):2213-8.
1994: Mombaerts P; Anderson S J; Perlmutter R M; Mak T W; Tonegawa S
An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.
Immunity 1994;1(4):261-7.
1994: Kimura T; Nakayama K; Penninger J; Kitagawa M; Harada H; Matsuyama T; Tanaka N; Kamijo R; Vilcek J; Mak T W
Involvement of the IRF-1 transcription factor in antiviral responses to interferons.
Science (New York, N.Y.) 1994;264(5167):1921-4.
1994: Tanaka N; Ishihara M; Kitagawa M; Harada H; Kimura T; Matsuyama T; Lamphier M S; Aizawa S; Mak T W; Taniguchi T
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.
Cell 1994;77(6):829-39.
1994: Wallace V A; Kondo S; Kono T; Xing Z; Timms E; Furlonger C; Keystone E; Gauldie J; Sauder D N; Mak T W
A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice.
European journal of immunology 1994;24(6):1463-6.
1994: Penninger J M; Wallace V A; Timms E; Mak T W
Maternal transfer of infectious mouse mammary tumor retroviruses does not depend on clonal deletion of superantigen-reactive V beta 14+ T cells.
European journal of immunology 1994;24(5):1102-8.
1994: Yeung R S; Penninger J; Mak T W
T-cell development and function in gene-knockout mice.
Current opinion in immunology 1994;6(2):298-307.
1994: Sebzda E; Wallace V A; Mayer J; Yeung R S; Mak T W; Ohashi P S
Positive and negative thymocyte selection induced by different concentrations of a single peptide.
Science (New York, N.Y.) 1994;263(5153):1615-8.
1994: Zhang L; Shannon J; Sheldon J; Teh H S; Mak T W; Miller R G
Role of infused CD8+ cells in the induction of peripheral tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2222-8.
1994: Zanke B; Squire J; Griesser H; Henry M; Suzuki H; Patterson B; Minden M; Mak T W
A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(2):236-44.
1994: Griesser H; Mak T W
The T-cell receptor--structure, function, and clinical application.
Hematologic pathology 1994;8(1-2):1-23.
1994: Ferrick D A; Gemmell-Hori L; Sydora B; Mulvania T; Penninger J M; Kronenberg M; Mak T W
Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice.
International reviews of immunology 1994;11(4):295-304.
1993: Penninger J M; Neu N; Timms E; Wallace V A; Koh D R; Kishihara K; Pummerer C; Mak T W
The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]
The Journal of experimental medicine 1993;178(5):1837-42.
1993: Fung-Leung W P; Louie M C; Limmer A; Ohashi P S; Ngo K; Chen L; Kawai K; Lacy E; Loh D Y; Mak T W
The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes.
European journal of immunology 1993;23(11):2834-40.
1993: Penninger J M; Wallace V A; Kishihara K; Mak T W
The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection.
Immunological reviews 1993;135():183-214.
1993: Rahemtulla A; Shahinian A; Kundig T; Zinkernagel R; Mak T W
CD4 negative mice as a model for immunodeficiency.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;342(1299):57-8.
1993: Chan I T; Limmer A; Louie M C; Bullock E D; Fung-Leung W P; Mak T W; Loh D Y
Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association.
Science (New York, N.Y.) 1993;261(5128):1581-4.
1993: Yeung R S; Penninger J; Mak T W
Genetically modified animals and immunodeficiency.
Current opinion in immunology 1993;5(4):585-94.
1993: Molina T J; Bachmann M F; Kündig T M; Zinkernagel R M; Mak T W
Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):699-706.
1993: Shahinian A; Pfeffer K; Lee K P; Kündig T M; Kishihara K; Wakeham A; Kawai K; Ohashi P S; Thompson C B; Mak T W
Differential T cell costimulatory requirements in CD28-deficient mice.
Science (New York, N.Y.) 1993;261(5121):609-12.
1993: Schilham M W; Fung-Leung W P; Rahemtulla A; Kuendig T; Zhang L; Potter J; Miller R G; Hengartner H; Mak T W
Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8.
European journal of immunology 1993;23(6):1299-304.
1993: Pfeffer K; Matsuyama T; Kündig T M; Wakeham A; Kishihara K; Shahinian A; Wiegmann K; Ohashi P S; Krönke M; Mak T W
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.
Cell 1993;73(3):457-67.
1993: Penninger J; Kishihara K; Molina T; Wallace V A; Timms E; Hedrick S M; Mak T W
Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells.
Science (New York, N.Y.) 1993;260(5106):358-61.
1993: Fung-Leung W P; Wallace V A; Gray D; Sha W C; Pircher H; Teh H S; Loh D Y; Mak T W
CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny.
European journal of immunology 1993;23(1):212-6.
1992: Wallace V A; Fung-Leung W P; Timms E; Gray D; Kishihara K; Loh D Y; Penninger J; Mak T W
CD45RA and CD45RBhigh expression induced by thymic selection events.
The Journal of experimental medicine 1992;176(6):1657-63.
1992: Wallace V A; Rahemtulla A; Timms E; Penninger J; Mak T W
CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.
The Journal of experimental medicine 1992;176(5):1459-63.
1992: Siderovski D P; Matsuyama T; Frigerio E; Chui S; Min X; Erfle H; Sumner-Smith M; Barnett R W; Mak T W
Random mutagenesis of the human immunodeficiency virus type-1 trans-activator of transcription (HIV-1 Tat).
Nucleic acids research 1992;20(20):5311-20.
1992: Trümper L H; Brady G; Vicini S; Cossman J; Mak T W
Gene expression in single Reed Sternberg cells of Hodgkin's disease: results from PCR generated single cell cDNA libraries.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1992;3 Suppl 4():25-6.
1992: Koh D R; Fung-Leung W P; Ho A; Gray D; Acha-Orbea H; Mak T W
Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice.
Science (New York, N.Y.) 1992;256(5060):1210-3.
1992: Mak T W; Rahemtulla A; Schilham M; Koh D R; Fung-Leung W P
Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting.
Journal of autoimmunity 1992;5 Suppl A():55-9.
1992: Zanke B; Suzuki H; Kishihara K; Mizzen L; Minden M; Pawson A; Mak T W
Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase).
European journal of immunology 1992;22(1):235-9.
1992: Mak T W; Rahemtulla A; Schilham M; Koh D R; Fung-Leung W P
Generation of mutant mice lacking surface expression of CD4 or CD8 gene targeting.
Advances in experimental medicine and biology 1992;323():73-7.
1991: Reis M D; Griesser H; Mak T W
Antigen receptor genes in hemopoietic malignancies.
Biochimica et biophysica acta 1991;1072(2-3):177-92.
1991: Fung-Leung W P; Kündig T M; Zinkernagel R M; Mak T W
Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression.
The Journal of experimental medicine 1991;174(6):1425-9.
1991: Martinez-Valdez H; Takihara Y; Champagne E; Minden M; Mak T W; Cohen A
Differential regulation of gamma and delta T cell antigen receptor gene expression by phorbol esters and Ca2+ ionophores in the acute lymphocyte leukemia DND41 cell line.
European journal of immunology 1991;21(10):2625-8.
1991: Hara J; Takihara Y; Yumura-Yagi K; Ishihara S; Tawa A; Mak T W; Gelfand E W; Okada S; Kawa-Ha K
Differential usage of delta recombining element and V delta genes during T-cell ontogeny.
Blood 1991;78(8):2075-81.
1991: Ferrick D A; Cumano A; Furlonger C; Min X; Iscove N N; Paige C J; Mak T W
Expansion of myelopoietic precursors and inhibition of B-cell precursors in mice that express a T-cell receptor gamma (V gamma 1.1J gamma 4C gamma 4) transgene.
Journal of cellular physiology 1991;148(3):457-63.
1991: Brändle D; Bürki K; Wallace V A; Rohrer U H; Mak T W; Malissen B; Hengartner H; Pircher H
Involvement of both T cell receptor V alpha and V beta variable region domains and alpha chain junctional region in viral antigen recognition.
European journal of immunology 1991;21(9):2195-202.
1991: Hara J; Kawa-Ha K; Takihara Y; Yumura-Yagi K; Ishihara S; Tawa A; Mak T W; Okada S; Gelfand E W
Developmental process of the T-cell receptor alpha and delta gene assembly in B-cell precursor acute lymphoblastic leukaemia.
British journal of haematology 1991;78(2):180-6.
1991: Fung-Leung W P; Schilham M W; Rahemtulla A; Kündig T M; Vollenweider M; Potter J; van Ewijk W; Mak T W
CD8 is needed for development of cytotoxic T cells but not helper T cells.
Cell 1991;65(3):443-9.
1991: Ferrick D A; Sydora B; Wallace V; Gemmell-Hori L; Kronenberg M; Mak T W
Self-reactive gamma delta T lymphocytes: implications for T-cell ontogeny and reactivity.
Immunological reviews 1991;120():51-69.
1991: Cheng S H; Penninger J M; Ferrick D A; Molina T J; Wallace V A; Mak T W
Biology of murine gamma delta T cells.
Critical reviews in immunology 1991;11(3-4):145-66.
1991: Penninger J; Wallace V A; Kishihara K; Molina T; Krause H; Mak T W
Molecular organization, ontogeny and expression of murine alpha beta and gamma delta T cell receptors.
Experimental and clinical immunogenetics 1991;8(2):57-74.
1991: Sheehy M J; Emler C A; Mak T W; Pandey J P
Human genes for the immunoglobulin gamma-chain (Gm) allotypes and for the T cell receptor alpha-chain are distantly linked or unlinked.
Experimental and clinical immunogenetics 1991;8(1):6-10.
1991: Ferrick D A; Gajewski D; Mak T W
First wave fetal thymocytes expressing V3J gamma 1C gamma 1-V delta 1J delta 2C delta T cell receptors are not required for alpha beta T cell receptor rearrangement and expression.
Advances in experimental medicine and biology 1991;292():47-51.
1990: Mak T W
Molecular similarities and differences between immunoglobulin and T cell receptors.
Behring Institute Mitteilungen 1990;(87):1-9.
1990: Ferrick D A; Ohashi P S; Wallace V A; Schilham M; Mak T W
Transgenic mice as an in vivo model for self-reactivity.
Immunological reviews 1990;118():257-83.
1990: Wallace V A; Ohashi P S; Hengartner H; Mak T W
Expression of CD4 can confer major histocompatibility complex class II-associated superantigen reactivity upon a T cell receptor derived from a CD8-dependent cytotoxic T lymphocyte clone.
European journal of immunology 1990;20(11):2471-7.
1990: Ohashi P S; Wallace V A; Broughton H; Ohashi C T; Ferrick D A; Jost V; Mak T W; Hengartner H; Pircher H
Specific deletion of the J-C delta locus in murine alpha/beta T cell clones and studies using transgenic mice.
European journal of immunology 1990;20(3):517-22.
1990: Pircher H; Ohashi P; Miescher G; Lang R; Zikopoulos A; Bürki K; Mak T W; MacDonald H R; Hengartner H
T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population.
European journal of immunology 1990;20(2):417-24.
1990: Reis M D; Griesser H; Mak T W
T cell receptor and immunoglobulin genes in hematologic malignancies.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1990;11 Suppl 1():59-77.
1990: Chan A; Du R P; Reis M; Meske L M; Sheehy M; Baillie E; Mak T W
Human T cell receptor V alpha gene polymorphism.
Experimental and clinical immunogenetics 1990;7(1):26-33.
1989: Ferrick D A; Ohashi P S; Wallace V; Schilham M; Mak T W
Thymic ontogeny and selection of alpha beta and gamma delta T cells.
Immunology today 1989;10(12):403-7.
1989: Sheehy M J; Meske L M; Emler C A; Rowe J R; Neme de Gimenez M H; Ingle C A; Chan A; Trucco M; Mak T W
Allelic T-cell receptor alpha complexes have little or no influence on susceptibility to type 1 diabetes.
Human immunology 1989;26(4):261-71.
1989: Yumura-Yagi K; Hara J; Terada N; Ishihara S; Tawa A; Takihara Y; Champagne E; Minden M D; Mak T W; Kawa-Ha K
Analysis of molecular events in leukemic cells arrested at an early stage of T-cell differentiation.
Blood 1989;74(6):2103-11.
1989: Hara J; Yumura-Yagi K; Tawa A; Ishihara S; Murata M; Terada N; Izumi Y; Champagne E; Takihara Y; Mak T W
Molecular analysis of acute undifferentiated leukemia: two distinct subgroups at the DNA and RNA levels.
Blood 1989;74(5):1738-46.
1989: Takadera T; Leung S; Gernone A; Koga Y; Takihara Y; Miyamoto N G; Mak T W
Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells.
Molecular and cellular biology 1989;9(5):2173-80.
1989: Griesser H; Tkachuk D; Reis M D; Mak T W
Gene rearrangements and translocations in lymphoproliferative diseases.
Blood 1989;73(6):1402-15.
1989: Ferrick D A; Sambhara S R; Ballhausen W; Iwamoto A; Pircher H; Walker C L; Yokoyama W M; Miller R G; Mak T W
T cell function and expression are dramatically altered in T cell receptor V gamma 1.1J gamma 4C gamma 4 transgenic mice.
Cell 1989;57(3):483-92.
1989: Champagne E; Takihara Y; Sagman U; de Sousa J; Burrow S; Lewis W H; Mak T W; Minden M D
The T-cell receptor delta chain locus is disrupted in the T-ALL associated t(11;14)(p13;q11) translocation.
Blood 1989;73(6):1672-6.
1989: Pircher H; Mak T W; Lang R; Ballhausen W; Rüedi E; Hengartner H; Zinkernagel R M; Bürki K
T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.
The EMBO journal 1989;8(3):719-27.
1989: Takihara Y; Champagne E; Ciccone E; Moretta L; Minden M; Mak T W
Organization and orientation of a human T cell receptor delta chain V gene segment that suggests an inversion mechanism is utilized in its rearrangement.
European journal of immunology 1989;19(3):571-4.
1989: Caccia N; Mak T W
Human T cell receptors.
Transplantation proceedings 1989;21(1 Pt 1):18-21.
1989: Takihara Y; Reimann J; Michalopoulos E; Ciccone E; Moretta L; Mak T W
Diversity and structure of human T cell receptor delta chain genes in peripheral blood gamma/delta-bearing T lymphocytes.
The Journal of experimental medicine 1989;169(2):393-405.
1989: Hara J; Benedict S H; Champagne E; Mak T W; Minden M; Gelfand E W
Relationship between rearrangement and transcription of the T-cell receptor alpha, beta, and gamma genes in B-precursor acute lymphoblastic leukemia.
Blood 1989;73(2):500-8.
1989: Reis M D; Griesser H; Mak T W
T cell receptor and immunoglobulin gene rearrangements in lymphoproliferative disorders.
Advances in cancer research 1989;52():45-80.
1989: Ferrick D A; Sambhara S R; Chadwick B S; Miller R G; Mak T W
The T-cell receptor repertoire is strikingly similar in older nude mice compared to normal adult mice.
Thymus 1989;13(1-2):103-11.
1989: Chan A; Du R P; Reis M; Baillie E; Meske L M; Sheehy M; Mak T W
Polymorphism of the human T cell receptor alpha chain variable genes: identification of a highly polymorphic V gene probe.
International immunology 1989;1(3):267-72.
1989: Ferrick D A; Min X; Gajewski D A; Mak T W
Phenotypic analysis of mice transgenic for the TCR C gamma 4 (V gamma 1.1J gamma 4C gamma 4) gene.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():57-60.
1989: Dutz J P; Chan A; Mak T; Siminovitch K A; Rubin L A
T cell receptor genes in rheumatoid arthritis.
Springer seminars in immunopathology 1989;11(3):289-99.
1989: Takihara Y; Caccia N; Yangai Y; Mak T W
Isolation of a T cell specific cDNA clone possibly involved in the T cell activation pathway.
International immunology 1989;1(1):59-65.
1988: Caccia N; Mak T W
T cell receptors.
The American journal of medicine 1988;85(6A):9-11.
1988: Hara J; Benedict S H; Champagne E; Takihara Y; Mak T W; Minden M; Gelfand E W
T cell receptor delta gene rearrangements in acute lymphoblastic leukemia.
The Journal of clinical investigation 1988;82(6):1974-82.
1988: Champagne E; Takihara Y; Sagman U; Burrow S; de Sousa J; Mak T W; Minden M D
The isolation of the human delta chain gene and its expression in normal T cells and T cell leukemias.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(11):717-21.
1988: Takihara Y; Tkachuk D; Michalopoulos E; Champagne E; Reimann J; Minden M; Mak T W
Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):6097-101.
1988: Tkachuk D C; Griesser H; Takihara Y; Champagne E; Minden M; Feller A C; Lennert K; Mak T W
Rearrangement of T-cell delta locus in lymphoproliferative disorders.
Blood 1988;72(1):353-7.
1988: Griesser H; Mak T W
Immunogenotyping in Hodgkin's disease.
Hematological oncology 1988;6(3):239-45.
1988: Champagne E; Sagman U; Biondi A; Lewis W H; Mak T W; Minden M D
Structure and rearrangement of the T cell receptor J alpha locus in T cells and leukemic T cell lines.
European journal of immunology 1988;18(7):1033-8.
1988: Koga Y; Lindstrom E; Fenyo E M; Wigzell H; Mak T W
High levels of heterodisperse RNAs accumulate in T cells infected with human immunodeficiency virus and in normal thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4521-5.
1988: Hara J; Benedict S H; Champagne E; Mak T W; Minden M; Gelfand E W
Comparison of T cell receptor alpha, beta, and gamma gene rearrangement and expression in T cell acute lymphoblastic leukemia.
The Journal of clinical investigation 1988;81(4):989-96.
1988: Ballhausen W G; Reske-Kunz A B; Tourvieille B; Ohashi P S; Parnes J R; Mak T W
Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma.
The Journal of experimental medicine 1988;167(4):1493-8.
1988: Griesser H; Champagne E; Tkachuk D; Takihara Y; Lalande M; Baillie E; Minden M; Mak T W
The human T cell receptor alpha-delta locus: a physical map of the variable, joining and constant region genes.
European journal of immunology 1988;18(4):641-4.
1988: Koga Y; Kimura N; Minowada J; Mak T W
Expression of the human T-cell-specific tyrosine kinase YT16 (lck) message in leukemic T-cell lines.
Cancer research 1988;48(4):856-9.
1988: Spolski R; Miescher G; Erard F; Risser R; MacDonald H R; Mak T W
Regulation of expression of T cell gamma chain, L3T4 and Ly-2 messages in Abelson/Moloney virus-transformed T cell lines.
European journal of immunology 1988;18(2):295-300.
1987: Hara J; Benedict S H; Mak T W; Gelfand E W
T cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia.
The Journal of clinical investigation 1987;80(6):1770-7.
1987: Pircher H; Michalopoulos E E; Iwamoto A; Ohashi P S; Baenziger J; Hengartner H; Zinkernagel R M; Mak T W
Molecular analysis of the antigen receptor of virus-specific cytotoxic T cells and identification of a new V alpha family.
European journal of immunology 1987;17(12):1843-6.
1987: Kimura N; Du R P; Mak T W
Rearrangement and organization of T cell receptor gamma chain genes in human leukemic T cell lines.
European journal of immunology 1987;17(11):1653-6.
1987: Reis M D; Mak T W
Monoclonality in human T-cell disorders.
Blood reviews 1987;1(2):89-96.
1981: Mager D; MacDonald M E; Robson I B; Mak T W; Bernstein A
Clonal analysis of the late stages of erythroleukemia induced by two distinct strains of Friend leukemia virus.
Molecular and cellular biology 1981;1(8):721-30.

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