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Nir Barzilai

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Kaori Kato; Clyde B Schechter; Joe Verghese; Richard Zweig; Nir Barzilai; Gil Atzmon
Personality, self-rated health, and cognition in centenarians: do personality and self-rated health relate to cognitive function in advanced age?
Yonah B Esterson; Nir Barzilai; Jill Crandall; Sylvia Kehlenbrink; Preeti Kishore; Sudha Koppaka; Stephanie Lawrence; Do-Eun Lee; Weijie Li; Julia Tonelli; Kehao Zhang; Meredith Hawkins
Fatty acid-induced production of plasminogen activator inhibitor-1 by adipose macrophages is greater in middle-aged versus younger adult participants.
Nir Barzilai; Luigi Ferrucci
Insulin resistance and aging: a cause or a protective response?

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2013: Kaori Kato; Clyde B Schechter; Joe Verghese; Richard Zweig; Nir Barzilai; Gil Atzmon
Personality, self-rated health, and cognition in centenarians: do personality and self-rated health relate to cognitive function in advanced age?
Aging 2013;5(3):183-91.
2012: Yonah B Esterson; Nir Barzilai; Jill Crandall; Sylvia Kehlenbrink; Preeti Kishore; Sudha Koppaka; Stephanie Lawrence; Do-Eun Lee; Weijie Li; Julia Tonelli; Kehao Zhang; Meredith Hawkins
Fatty acid-induced production of plasminogen activator inhibitor-1 by adipose macrophages is greater in middle-aged versus younger adult participants.
The journals of gerontology. Series A, Biological sciences and medical sciences 2012;67(12):1321-8.
2012: Nir Barzilai; Luigi Ferrucci
Insulin resistance and aging: a cause or a protective response?
The journals of gerontology. Series A, Biological sciences and medical sciences 2012;67(12):1329-31.
2012: Derek M Huffman; Eline P Slagboom; Kenny Ye; Nir Barzilai; Aviv Bergman; Joris Deelen; Gil Atzmon
Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.
The journals of gerontology. Series A, Biological sciences and medical sciences 2012;67(11):1153-60.
2012: Nir Barzilai; Leonard Guarente; Thomas B L Kirkwood; Linda Partridge; Thomas A Rando; P Eline Slagboom
The place of genetics in ageing research.
Nature reviews. Genetics 2012;13(8):589-94.
2012: Nir Barzilai; Derek M Huffman; Radhika Muzumdar; Andrzej Bartke
The critical role of metabolic pathways in aging.
Diabetes 2012;61(6):1315-22.
2012: Kaori Kato; Richard Zweig; Nir Barzilai; Gil Atzmon
Positive attitude towards life and emotional expression as personality phenotypes for centenarians.
Aging 2012;4(5):359-67.
2012: Guiqing Cai; Jonathan L Haines; Adam C Naj; Margaret Pericak-Vance; Mary Sano; Gil Atzmon; Nir Barzilai; Gary Beecham; Joseph Buxbaum
Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease.
Neurobiology of aging 2012;33(2):416-417.e3.
2012: Saurabh Gombar; Jan H J Hoeijmakers; Hwa Jin Jung; Joris Pothof; Gil Atzmon; Nir Barzilai; Brent Calder; Judith Campisi; Feng Dong; Xiao-Li Tian; Jan Vijg; Yousin Suh
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing.
BMC genomics 2012;13():353.
2012: Shani Ben-Shlomo; Nir Barzilai; Dikla Atias; Amir Shlomai; Francine Einstein; Isabel Zvibel; Zamir Halpern; Sigal Fishman
Perinephric and epididymal fat affect hepatic metabolism in rats.
Obesity (Silver Spring, Md.) 2012;20(1):151-6.
2011: Vafa Tabatabaie; Gil Atzmon; Nir Barzilai; Ruth Freeman; swapnil rajpathak; Jill Crandall
Exceptional longevity is associated with decreased reproduction.
Aging 2011;3(12):1202-5.
2011: Colette Knight; Tony K T Lam; Gary J Schwartz; Isabel Arrieta-Cruz; Nir Barzilai; Roger Gutierrez-Juarez; Loli Huang; Luciano Rossetti
Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats.
Diabetes 2011;60(11):2691-700.
2011: swapnil rajpathak; Saritha Reddy; Gil Atzmon; Orit Ben-David; Jill Crandall; Yingheng Liu; Nir Barzilai
Lifestyle factors of people with exceptional longevity.
Journal of the American Geriatrics Society 2011;59(8):1509-12.
2011: Cagdas Tazearslan; Jing Huang; Nir Barzilai; Yousin Suh
Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles.
Aging cell 2011;10(3):551-4.
2011: Shani Ben-Shlomo; Isabel Zvibel; Mati Shnell; Amir Shlomai; Elena Chepurko; Zamir Halpern; Nir Barzilai; Ran Oren; Sigal Fishman
Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase.
Journal of hepatology 2011;54(6):1214-23.
2011: Nir Barzilai; Hua Guo; Erin M Mahoney; Suzanne Caporossi; Gregory T Golm; Ronald B Langdon; Debora Williams-Herman; Keith D Kaufman; John M Amatruda; Barry J Goldstein; Helmut Steinberg
Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.
Current medical research and opinion 2011;27(5):1049-58.
2010: Nir Barzilai; Ilan Gabriely; Gil Atzmon; Devorah Rothenberg; Yousin Suh; Aviv Bergman
Genetic studies reveal the role of the endocrine and metabolic systems in aging.
The Journal of clinical endocrinology and metabolism 2010;95(10):4493-500.
2010: Francine Einstein; Derek M Huffman; Sigal Fishman; Elina Jerschow; Hye Heo; Gil Atzmon; Clyde Schechter; Nir Barzilai; Radhika Muzumdar
Aging per se increases the susceptibility to free fatty acid-induced insulin resistance.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(8):800-8.
2010: Reid F Thompson; Gil Atzmon; Ciprian Gheorghe; Hong Qian Liang; Christina Lowes; John M Greally; Nir Barzilai
Tissue-specific dysregulation of DNA methylation in aging.
Aging cell 2010;9(4):506-18.
2010: Clyde Schechter; Nir Barzilai; Jill Crandall; Gil Atzmon
Cholesteryl ester transfer protein (CETP) genotype and reduced CETP levels associated with decreased prevalence of hypertension.
Mayo Clinic proceedings. Mayo Clinic 2010;85(6):522-6.
2010: richard lipton; Jamie Hirsch; Mindy Katz; Cuiling Wang; Amy Sanders; Joe Verghese; Nir Barzilai; Carol A Derby
Exceptional parental longevity associated with lower risk of Alzheimer's disease and memory decline.
Journal of the American Geriatrics Society 2010;58(6):1043-9.
2010: Reid F Thompson; Melissa Fazzari; Hongshun Niu; Nir Barzilai; Rebecca A Simmons; John M Greally
Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats.
The Journal of biological chemistry 2010;285(20):15111-8.
2010: Gil Atzmon; Miook Cho; Richard M Cawthon; Temuri Budagov; Micol Katz; Xiaoman Yang; Glenn Siegel; Aviv Bergman; Derek M Huffman; Clyde Schechter; Woodring E Wright; Jerry W Shay; Nir Barzilai; Diddahally R Govindaraju; Yousin Suh
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians.
Proceedings of the National Academy of Sciences of the United States of America 2010;107 Suppl 1():1710-7.
2010: Amy Sanders; Cuiling Wang; Mindy Katz; Carol A Derby; Nir Barzilai; Laurie Ozelius; richard lipton
Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia.
JAMA : the journal of the American Medical Association 2010;303(2):150-8.
2010: Derek M Huffman; Nir Barzilai
Contribution of adipose tissue to health span and longevity.
Interdisciplinary topics in gerontology 2010;37():1-19.
2010: Rosalind J Neuman; Jon Wasson; Gil Atzmon; Julio Wainstein; Yair Yerushalmi; Joseph Cohen; Nir Barzilai; Ilana Blech; Benjamin Glaser; M Alan Permutt
Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.
PloS one 2010;5(3):e9903.
2010: Francine Einstein; Reid F Thompson; Tushar D Bhagat; Melissa Fazzari; Amit Verma; Nir Barzilai; John M Greally
Cytosine methylation dysregulation in neonates following intrauterine growth restriction.
PloS one 2010;5(1):e8887.
2009: Gil Atzmon; Nir Barzilai; Martin I Surks; Ilan Gabriely
Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity.
The Journal of clinical endocrinology and metabolism 2009;94(12):4768-75.
2009: Ranganath Muniyappa; Radhika Muzumdar; Nir Barzilai; Hui Chen; Francine Einstein; Xu Yan; Lilly Q Yue; Michael Quon
Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats.
American journal of physiology. Endocrinology and metabolism 2009;297(5):E1023-9.
2009: swapnil rajpathak; Dharam J Kumbhani; Jill Crandall; Nir Barzilai; Michael H Alderman; Paul M Ridker
Statin therapy and risk of developing type 2 diabetes: a meta-analysis.
Diabetes care 2009;32(10):1924-9.
2009: Derek M Huffman; Nir Barzilai
Role of visceral adipose tissue in aging.
Biochimica et biophysica acta 2009;1790(10):1117-23.
2009: Ludmila Pawlikowska; Donglei Hu; Scott Huntsman; Andrew Sung; Catherine Chu; Justin Chen; Alexander H Joyner; Nicholas J Schork; Wen-Chi Hsueh; Alexander P Reiner; Bruce M Psaty; Gil Atzmon; Nir Barzilai; Steven R Cummings; Warren S Browner; Pui-Yan Kwok; Elad Ziv
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.
Aging cell 2009;8(4):460-72.
2009: Jeremy Walston; Amy M Matteini; Caroline Nievergelt; Leslie A Lange; Dani M Fallin; Nir Barzilai; Elad Ziv; Ludmila Pawlikowska; Pui Kwok; Steve R Cummings; Charles Kooperberg; Andrea LaCroix; Russell P Tracy; Gil Atzmon; Ethan M Lange; Alex P Reiner
Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.
Experimental gerontology 2009;44(5):350-5.
2009: Jill Crandall; Harry Shamoon; Hillel W Cohen; Migdalia Reid; Srikanth Gajavelli; Georgeta Trandafirescu; Vafa Tabatabaie; Nir Barzilai
Post-challenge hyperglycemia in older adults is associated with increased cardiovascular risk profile.
The Journal of clinical endocrinology and metabolism 2009;94(5):1595-601.
2009: Gil Atzmon; Nir Barzilai; Joseph G Hollowell; Martin I Surks; Ilan Gabriely
Extreme longevity is associated with increased serum thyrotropin.
The Journal of clinical endocrinology and metabolism 2009;94(4):1251-4.
2009: Nir Barzilai; Andrzej Bartke
Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(2):187-91.
2009: Paola Sebastiani; Monty Montano; Annibale Puca; Nadia Solovieff; Toshio Kojima; Meng C Wang; Efthymia Melista; Micah Meltzer; Sylvia E J Fischer; Stacy Andersen; Stephen H Hartley; Amanda Sedgewick; Yasumichi Arai; Aviv Bergman; Nir Barzilai; Dellara F Terry; Alberto Riva; Chiara Viviani Anselmi; Alberto Malovini; Aya Kitamoto; Motoji Sawabe; Tomio Arai; Yasuyuki Gondo; Martin H Steinberg; Nobuyoshi Hirose; Gil Atzmon; Gary Ruvkun; Clinton T Baldwin; Thomas T Perls
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.
PloS one 2009;4(12):e8210.
2009: Radhika Muzumdar; Derek M Huffman; Gil Atzmon; Christoph Buettner; Laura J Cobb; Sigal Fishman; Temuri Budagov; Lingguang Cui; Francine Einstein; Aruna Poduval; David Hwang; Nir Barzilai; Pinchas Cohen
Humanin: a novel central regulator of peripheral insulin action.
PloS one 2009;4(7):e6334.
2008: Francine Einstein; Sigal Fishman; Jeffery Bauman; Reid Thompson; Derek M Huffman; Gil Atzmon; Nir Barzilai; Radhika Muzumdar
Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3450-7.
2008: Radhika Muzumdar; David Allison; Derek M Huffman; Xiaohui Ma; Gil Atzmon; Francine Einstein; Sigal Fishman; Aruna D Poduval; Theresa McVei; Scott W Keith; Nir Barzilai
Visceral adipose tissue modulates mammalian longevity.
Aging cell 2008;7(3):438-40.
2008: Gil Atzmon; Toni I Pollin; Jill Crandall; Keith Tanner; Clyde Schechter; Philipp E Scherer; Marielisa Rincon; Glenn Siegel; Micol Katz; richard lipton; Alan R Shuldiner; Nir Barzilai
Adiponectin levels and genotype: a potential regulator of life span in humans.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(5):447-53.
2008: Yousin Suh; Gil Atzmon; Mi-Ook Cho; David Hwang; Bingrong Liu; Daniel J Leahy; Nir Barzilai; Pinchas Cohen
Functionally significant insulin-like growth factor I receptor mutations in centenarians.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3438-42.
2008: Francine Einstein; Sigal Fishman; Radhika Muzumdar; Xiao Man Yang; Gil Atzmon; Nir Barzilai
Accretion of visceral fat and hepatic insulin resistance in pregnant rats.
American journal of physiology. Endocrinology and metabolism 2008;294(2):E451-5.
2008: Liran Shlush; Gil Atzmon; Roni Weisshof; Doron Behar; Guenady Yudkovsky; Nir Barzilai; Karl Skorecki
Ashkenazi Jewish centenarians do not demonstrate enrichment in mitochondrial haplogroup J.
PloS one 2008;3(10):e3425.
2007: Jong-Hee Hwang; Daniel Stein; Nir Barzilai; Min-Hui Cui; Julia Tonelli; Preeti Kishore; Meredith Hawkins
Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1663-9.
2007: Aviv Bergman; Gil Atzmon; Qian Ye; Thomas MacCarthy; Nir Barzilai
Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging.
PLoS computational biology 2007;3(8):e170.
2007: George M Martin; Aviv Bergman; Nir Barzilai
Genetic determinants of human health span and life span: progress and new opportunities.
PLoS genetics 2007;3(7):e125.
2007: Nahoko Iwata; Jin Zhang; Gil Atzmon; Suzanne Leanza; Jaehyoung Cho; Anne Chomyn; Robert D Burk; Nir Barzilai; Giuseppe Attardi
Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians.
Mitochondrion 2007;7(4):267-72.
2007: Hae Soon Kim; Omar Ali; Melanie Shim; Kuk-Wha Lee; Patricia Vuguin; Radhika Muzumdar; Nir Barzilai; Pinchas Cohen
Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo.
Pediatric research 2007;61(2):159-64.
2007: Sigal Fishman; Radhika Muzumdar; Gil Atzmon; Xiaohui Ma; Xiaoman Yang; Francine Einstein; Nir Barzilai
Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(1):53-60.
2006: Nir Barzilai; Gil Atzmon; Carol A Derby; J M Bauman; richard lipton
A genotype of exceptional longevity is associated with preservation of cognitive function.
Neurology 2006;67(12):2170-5.
2006: Dellara F Terry; Diego F Wyszynski; Vikki G Nolan; Gil Atzmon; Emily A Schoenhofen; JaeMi Pennington; Stacy L Andersen; Marsha A. Wilcox; Lindsay A Farrer; Nir Barzilai; Clinton T Baldwin; Alexzander Asea
Serum heat shock protein 70 level as a biomarker of exceptional longevity.
Mechanisms of ageing and development 2006;127(11):862-8.
2006: Radhika Muzumdar; Xiaohui Ma; Sigal Fishman; Xiaoman Yang; Gil Atzmon; Patricia Vuguin; Francine Einstein; David Hwang; Pinchas Cohen; Nir Barzilai
Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action.
Diabetes 2006;55(10):2788-96.
2006: Radhika Muzumdar; Xiaohui Ma; Xiaoman Yang; Gil Atzmon; Nir Barzilai
Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging.
Neurobiology of aging 2006;27(9):1308-14.
2006: Gil Atzmon; Marielisa Rincon; Clyde Schechter; Alan R Shuldiner; richard lipton; Aviv Bergman; Nir Barzilai
Lipoprotein genotype and conserved pathway for exceptional longevity in humans.
PLoS biology 2006;4(4):e113.
2005: Marielisa Rincon; Eric Rudin; Nir Barzilai
The insulin/IGF-1 signaling in mammals and its relevance to human longevity.
Experimental gerontology 2005;40(11):873-7.
2005: Dan E Arking; Gil Atzmon; Albert Arking; Nir Barzilai; Harry C Dietz
Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity.
Circulation research 2005;96(4):412-8.
2005: Francine Einstein; Gil Atzmon; Xiao Man Yang; Xiao Hui Ma; Marielisa Rincon; Eric Rudin; Radhika Muzumdar; Nir Barzilai
Differential responses of visceral and subcutaneous fat depots to nutrients.
Diabetes 2005;54(3):672-8.
2005: Ying Lin; Anders H Berg; Puneeth Iyengar; Tony K T Lam; Adria Giacca; Terry P Combs; Michael W Rajala; Xue-Liang Du; Brent Rollman; Weijie Li; Meredith Hawkins; Nir Barzilai; Christopher J Rhodes; I George Fantus; Michael Brownlee; Philipp E Scherer
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
The Journal of biological chemistry 2005;280(6):4617-26.
2005: Gil Atzmon; Marielisa Rincon; Pegah Rabizadeh; Nir Barzilai
Biological evidence for inheritance of exceptional longevity.
Mechanisms of ageing and development 2005;126(2):341-5.
2005: Amiela Globerson; Nir Barzilai
The voyage to healthy longevity: from experimental models to the ultimate goal.
Mechanisms of ageing and development 2005;126(2):225-9.
2004: Patricia Vuguin; Elisabeth Raab; Bing Liu; Nir Barzilai; Rebecca Simmons
Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation.
Diabetes 2004;53(10):2617-22.
2004: Marielisa Rincon; Radhika Muzumdar; Gil Atzmon; Nir Barzilai
The paradox of the insulin/IGF-1 signaling pathway in longevity.
Mechanisms of ageing and development 2004;125(6):397-403.
2004: Nir Barzilai; Luciano Rossetti; richard lipton
Einstein's Institute for Aging Research: collaborative and programmatic approaches in the search for successful aging.
Experimental gerontology 2004;39(2):151-7.
2004: M Das; Ilan Gabriely; Nir Barzilai
Caloric restriction, body fat and ageing in experimental models.
Obesity reviews : an official journal of the International Association for the Study of Obesity 2004;5(1):13-9.
2004: Radhika Muzumdar; Xiaohui Ma; Gil Atzmon; Patricia Vuguin; Xiaoman Yang; Nir Barzilai
Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action.
Diabetes 2004;53(2):441-6.
2004: Gil Atzmon; Clyde Schechter; William Greiner; Deborah Davidson; Gad Rennert; Nir Barzilai
Clinical phenotype of families with longevity.
Journal of the American Geriatrics Society 2004;52(2):274-7.
2003: Nir Barzilai; Gil Atzmon; Clyde Schechter; Ernst Schaefer; Adrienne L Cupples; richard lipton; Suzanne Cheng; Alan R Shuldiner
Unique lipoprotein phenotype and genotype associated with exceptional longevity.
JAMA : the journal of the American Medical Association 2003;290(15):2030-40.
2003: Craig S Atwood; Nir Barzilai; Richard L Bowen; Holly M Brown-Borg; David F Jarrard; Vivian X Fu; Leonie K Heilbronn; Donald Ingram; Eric Ravussin; Robert S Schwartz; Richard Weindruch
Pennington scientific symposium on mechanisms and retardation of aging.
Experimental gerontology 2003;38(10):1217-26.
2003: Robert N Butler; Steven Austad; Nir Barzilai; Andreas Braun; Stephen Helfand; Pamela Larsen; Anna M McCormick; Thomas T Perls; Alan R Shuldiner; Richard L Sprott; Huber R Warner
Longevity genes: from primitive organisms to humans.
The journals of gerontology. Series A, Biological sciences and medical sciences 2003;58(7):581-4.
2003: Ilan Gabriely; Nir Barzilai
Surgical removal of visceral adipose tissue: effects on insulin action.
Current diabetes reports 2003;3(3):201-6.
2003: Radhika Muzumdar; Xiaohui Ma; Xiaoman Yang; Gil Atzmon; Julia Bernstein; George Karkanias; Nir Barzilai
Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1130-2.
2003: Nir Barzilai
Discovering the secrets of successful longevity.
The journals of gerontology. Series A, Biological sciences and medical sciences 2003;58(3):225-6.
2003: Jill Crandall; Nir Barzilai
Treatment of diabetes mellitus in older people: oral therapy options.
Journal of the American Geriatrics Society 2003;51(2):272-4.
2002: Gil Atzmon; Xiao Man Yang; Radhika Muzumdar; Xiao Hui Ma; Ilan Gabriely; Nir Barzilai
Differential gene expression between visceral and subcutaneous fat depots.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(11-12):622-8.
2002: Gil Atzmon; Ilan Gabriely; William Greiner; Deborah Davidson; Clyde Schechter; Nir Barzilai
Plasma HDL levels highly correlate with cognitive function in exceptional longevity.
The journals of gerontology. Series A, Biological sciences and medical sciences 2002;57(11):M712-5.
2002: Ilan Gabriely; Xiao Hui Ma; Xiao Man Yang; Gil Atzmon; Michael W Rajala; Anders H Berg; Phillip Scherer; Luciano Rossetti; Nir Barzilai
Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?
Diabetes 2002;51(10):2951-8.
2002: Michael W Rajala; Ying Lin; Mollie Ranalletta; Xiao Man Yang; Hao Qian; Ron Gingerich; Nir Barzilai; Philipp E Scherer
Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1920-30.
2002: Xiao Hui Ma; Radhika Muzumdar; Xiao Man Yang; Ilan Gabriely; Rachel Berger; Nir Barzilai
Aging is associated with resistance to effects of leptin on fat distribution and insulin action.
The journals of gerontology. Series A, Biological sciences and medical sciences 2002;57(6):B225-31.
2002: Ilan Gabriely; Xiao Hui Ma; Xiao Man Yang; Luciano Rossetti; Nir Barzilai
Leptin resistance during aging is independent of fat mass.
Diabetes 2002;51(4):1016-21.
2002: Ilan Gabriely; Xiao Man Yang; Jane A Cases; Xiao Hui Ma; Luciano Rossetti; Nir Barzilai
Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway.
Atherosclerosis 2002;160(1):115-22.
2001: J Wang; S Obici; K Morgan; Nir Barzilai; Z Feng; L Rossetti
Overfeeding rapidly induces leptin and insulin resistance.
Diabetes 2001;50(12):2786-91.
2001: Y Lin; Michael W Rajala; Joel P Berger; D E Moller; Nir Barzilai; Philipp E Scherer
Hyperglycemia-induced production of acute phase reactants in adipose tissue.
The Journal of biological chemistry 2001;276(45):42077-83.
2001: A Pirogovsky; M Adi; A Dagan; L Sinai; D Sthoeger; Nir Barzilai; E Tabachnik
Superior sagittal sinus thrombosis: a rare complication in a child with nephrotic syndrome.
Pediatric radiology 2001;31(10):709-11.
2001: Ilan Gabriely; Nir Barzilai
The role of fat cell derived peptides in age-related metabolic alterations.
Mechanisms of ageing and development 2001;122(14):1565-76.
2001: Ilan Gabriely; Xiao Man Yang; Jane A Cases; Xiao Hui Ma; Luciano Rossetti; Nir Barzilai
Hyperglycemia modulates angiotensinogen gene expression.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(3):R795-802.
2001: Patricia Vuguin; X Ma; X Yang; M Surana; B Liu; Nir Barzilai
Food deprivation limits insulin secretory capacity in postpubertal rats.
Pediatric research 2001;49(4):468-73.
2001: Nir Barzilai; Ilan Gabriely
The role of fat depletion in the biological benefits of caloric restriction.
The Journal of nutrition 2001;131(3):903S-906S.
2001: Jane A Cases; Ilan Gabriely; Xiao Hui Ma; Xiao Man Yang; T Michaeli; Norman Fleischer; Luciano Rossetti; Nir Barzilai
Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo.
Diabetes 2001;50(2):348-52.
2001: Nir Barzilai; Alan R Shuldiner
Searching for human longevity genes: the future history of gerontology in the post-genomic era.
The journals of gerontology. Series A, Biological sciences and medical sciences 2001;56(2):M83-7.
2001: Nir Barzilai; Ilan Gabriely; M Gabriely; N Iankowitz; John D Sorkin
Offspring of centenarians have a favorable lipid profile.
Journal of the American Geriatrics Society 2001;49(1):76-9.
2000: Jane A Cases; Nir Barzilai
The regulation of body fat distribution and the modulation of insulin action.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 4():S63-6.
2000: G Gupta; Jane A Cases; li she; Xiao Hui Ma; Xiao Man Yang; M Hu; J Wu; Luciano Rossetti; Nir Barzilai
Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation.
American journal of physiology. Endocrinology and metabolism 2000;278(6):E985-91.
2000: G Gupta; li she; Xiao Hui Ma; Xiao Man Yang; M Hu; Jane A Cases; Patricia Vuguin; Luciano Rossetti; Nir Barzilai
Aging does not contribute to the decline in insulin action on storage of muscle glycogen in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(1):R111-7.
1999: Nir Barzilai; G Gupta
Interaction between aging and syndrome X: new insights on the pathophysiology of fat distribution.
Annals of the New York Academy of Sciences 1999;892():58-72.
1999: Nir Barzilai
Obesity: age-associated weight gain and the development of disease. An interview with Nir Barzilai. Interview by Marc E. Weksler.
Geriatrics 1999;54(11):57-8, 61-4.
1999: Meredith Hawkins; M Hu; J Yu; H Eder; Patricia Vuguin; li she; Nir Barzilai; M Leiser; Jonathan M Backer; Luciano Rossetti
Discordant effects of glucosamine on insulin-stimulated glucose metabolism and phosphatidylinositol 3-kinase activity.
The Journal of biological chemistry 1999;274(44):31312-9.
1999: Nir Barzilai; li she; L Liu; J Wang; M Hu; Patricia Vuguin; Luciano Rossetti
Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action.
The American journal of physiology 1999;277(2 Pt 1):E291-8.
1999: J Wang; R Liu; L Liu; R Chowdhury; Nir Barzilai; J Tan; L Rossetti
The effect of leptin on Lep expression is tissue-specific and nutritionally regulated.
Nature medicine 1999;5(8):895-9.
1999: Nir Barzilai; G Gupta
Revisiting the role of fat mass in the life extension induced by caloric restriction.
The journals of gerontology. Series A, Biological sciences and medical sciences 1999;54(3):B89-96; discussion B97-8.
1999: Nir Barzilai; li she; B Q Liu; Patricia Vuguin; P Cohen; J Wang; Luciano Rossetti
Surgical removal of visceral fat reverses hepatic insulin resistance.
Diabetes 1999;48(1):94-8.
1998: L Liu; George Karkanias; Jose C Morales; Meredith Hawkins; Nir Barzilai; J Wang; Luciano Rossetti
Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes.
The Journal of biological chemistry 1998;273(47):31160-7.
1998: A Schattner; Nir Barzilai
Sternoclavicular septic arthritis: a novel cause of pleural effusion.
The American journal of medicine 1998;105(1):85-6.
1998: J Wang; R Liu; Meredith Hawkins; Nir Barzilai; Luciano Rossetti
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.
Nature 1998;393(6686):684-8.
1998: Nir Barzilai; S Banerjee; Meredith Hawkins; W Chen; Luciano Rossetti
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.
The Journal of clinical investigation 1998;101(7):1353-61.
1998: Nir Barzilai; S Banerjee; Meredith Hawkins; C J Chang; W Chen; L Rossetti
The effect of age-dependent increase in fat mass on peripheral insulin action is saturable.
The journals of gerontology. Series A, Biological sciences and medical sciences 1998;53(2):B141-6.
1998: D Massillon; W Chen; Nir Barzilai; D Prus-Wertheimer; Meredith Hawkins; R Liu; R Taub; Luciano Rossetti
Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phosphoenolpyruvate carboxykinase genes in conscious rats.
The Journal of biological chemistry 1998;273(1):228-34.
1997: Nir Barzilai; J Wang; D Massilon; Patricia Vuguin; Meredith Hawkins; Luciano Rossetti
Leptin selectively decreases visceral adiposity and enhances insulin action.
The Journal of clinical investigation 1997;100(12):3105-10.
1997: Luciano Rossetti; D Massillon; Nir Barzilai; Patricia Vuguin; W Chen; Meredith Hawkins; J Wu; J Wang
Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action.
The Journal of biological chemistry 1997;272(44):27758-63.
1997: S Banerjee; P Saenger; M Hu; W Chen; Nir Barzilai
Fat accretion and the regulation of insulin-mediated glycogen synthesis after puberty in rats.
The American journal of physiology 1997;273(4 Pt 2):R1534-9.
1997: Luciano Rossetti; W Chen; M Hu; Meredith Hawkins; Nir Barzilai; S Efrat
Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.
The American journal of physiology 1997;273(4 Pt 1):E743-50.
1997: Luciano Rossetti; Antine Elaine Stenbit; W Chen; M Hu; Nir Barzilai; Ellen B Katz; Maureen J Charron
Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene.
The Journal of clinical investigation 1997;100(7):1831-9.
1997: Meredith Hawkins; Nir Barzilai; R Liu; M Hu; W Chen; Luciano Rossetti
Role of the glucosamine pathway in fat-induced insulin resistance.
The Journal of clinical investigation 1997;99(9):2173-82.
1997: S Raghavan; Paul Saenger; M Hu; Nir Barzilai
Intracellular pathways of insulin-mediated glucose uptake before and after puberty in conscious rats.
Pediatric research 1997;41(3):340-5.
1997: Meredith Hawkins; I Angelov; R Liu; Nir Barzilai; L Rossetti
The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake.
The Journal of biological chemistry 1997;272(8):4889-95.
1997: D Massillon; Nir Barzilai; Meredith Hawkins; D Prus-Wertheimer; Luciano Rossetti
Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion.
Diabetes 1997;46(1):153-7.
1996: Meredith Hawkins; Nir Barzilai; W Chen; I Angelov; M Hu; P Cohen; Luciano Rossetti
Increased hexosamine availability similarly impairs the action of insulin and IGF-1 on glucose disposal.
Diabetes 1996;45(12):1734-43.
1996: D Hauser; Nir Barzilai; Miriam Zalish; M Oliver; Ayala Pollack
Bilateral papilledema with retinal hemorrhages in association with cerebral venous sinus thrombosis and paroxysmal nocturnal hemoglobinuria.
American journal of ophthalmology 1996;122(4):592-3.
1996: Nir Barzilai; Meredith Hawkins; I Angelov; M Hu; Luciano Rossetti
Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production.
Diabetes 1996;45(10):1329-35.
1996: Nir Barzilai; Luciano Rossetti
Age-related changes in body composition are associated with hepatic insulin resistance in conscious rats.
The American journal of physiology 1996;270(6 Pt 1):E930-6.
1996: D Massillon; Nir Barzilai; W Chen; M Hu; Luciano Rossetti
Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats.
The Journal of biological chemistry 1996;271(17):9871-4.
1996: Luciano Rossetti; Nir Barzilai; W Chen; Thomas M Harris; Deyun Yang; Charles E Rogler
Hepatic overexpression of insulin-like growth factor-II in adulthood increases basal and insulin-stimulated glucose disposal in conscious mice.
The Journal of biological chemistry 1996;271(1):203-8.
1995: Nir Barzilai; P H Groop; L Groop; Ralph DeFronzo
A novel mechanism of glipizide sulfonylurea action: decreased metabolic clearance rate of insulin.
Acta diabetologica 1995;32(4):273-8.
1995: D Massillon; W Chen; Meredith Hawkins; R Liu; Nir Barzilai; Luciano Rossetti
Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice.
The American journal of physiology 1995;269(6 Pt 1):E1037-43.
1995: D Bali; A Svetlanov; H W Lee; D Fusco-DeMane; M Leiser; B Li; Nir Barzilai; M Surana; Harry Hou; Norman Fleischer
Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene.
The Journal of biological chemistry 1995;270(37):21464-7.
1995: Nir Barzilai; D Massillon; Luciano Rossetti
Effects of fasting on hepatic and peripheral glucose metabolism in conscious rats with near-total fat depletion.
The Biochemical journal 1995;310 ( Pt 3)():819-26.
1995: Nir Barzilai; Luciano Rossetti
Relationship between changes in body composition and insulin responsiveness in models of the aging rat.
The American journal of physiology 1995;269(3 Pt 1):E591-7.
1995: Luciano Rossetti; Meredith Hawkins; W Chen; J Gindi; Nir Barzilai
In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats.
The Journal of clinical investigation 1995;96(1):132-40.
1995: P Cohen; Nir Barzilai; Eddy Karnieli
Suppression of insulin secretion by C-peptide infusion in humans.
Israel journal of medical sciences 1995;31(5):284-8.
1995: I Kogan; Nir Barzilai; E Hay; A Fruman
[Ultrasound evaluation of acute abdominal pain in the emergency department].
Harefuah 1995;128(8):484-7, 527.
1995: U Ben Aharon; O Lifscitz; S D Strano; E Mavor; Nir Barzilai
[Surgical treatment of nonpalpable mammographic abnormalities using guidewire localization].
Harefuah 1995;128(4):205-7, 264.
1994: M Guy; D Singer; Nir Barzilai; S Eisenkraft
Primary classic Kaposi's sarcoma of glans penis--appearance on magnetic resonance imaging.
British journal of urology 1994;74(4):521-2.
1994: A Eliraz; Nir Barzilai
[Chest X-ray and computerized tomography of the chest: are we exaggerating?].
Harefuah 1994;126(10):620-1.
1993: Nir Barzilai; Luciano Rossetti
Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin.
The Journal of biological chemistry 1993;268(33):25019-25.
1993: Luciano Rossetti; Andrea Giaccari; Nir Barzilai; K Howard; G Sebel; M Hu
Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes.
The Journal of clinical investigation 1993;92(3):1126-34.
1993: Nir Barzilai; Eddy Karnieli; D Barzilai; P Cohen
Correlation between glucose disposal and amino acids levels in hyperthyroidism.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1993;25(7):382-5.
1993: P J Deutsch; V C Schadlow; Nir Barzilai
38-Amino acid form of pituitary adenylate cyclase activating peptide induces process outgrowth in human neuroblastoma cells.
Journal of neuroscience research 1993;35(3):312-20.
1993: A Kagan; L Sinay-Trieman; B Czernobilsky; Nir Barzilai; Y Bar-Khayim
Is the association between crescentic glomerulonephritis and renal cell carcinoma coincidental?
Nephron 1993;65(4):642-3.
1992: V C Schadlow; Nir Barzilai; P J Deutsch
Regulation of gene expression in PC12 cells via an activator of dual second messengers: pituitary adenylate cyclase activating polypeptide.
Molecular biology of the cell 1992;3(8):941-51.
1992: D Mishaly; S Pasik; Nir Barzilai; A Mashiah
Repair of internal carotid aneurysm under local anaesthesia. Case report.
The Journal of cardiovascular surgery 1992;33(3):380-2.
1992: M Geist; Nir Barzilai
[Dilutional hyponatremia and convulsions after strenuous exercise].
Harefuah 1992;122(7):420-1, 480, 479.
1991: Ralph DeFronzo; Nir Barzilai; D C Simonson
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects.
The Journal of clinical endocrinology and metabolism 1991;73(6):1294-301.
1991: Nir Barzilai; P Cohen; Eddy Karnieli; R Enat; O Epstein; J Owen; N McIntyre
In vivo insulin action in hepatocellular and cholestatic liver cirrhosis.
Journal of endocrinological investigation 1991;14(9):727-35.
1991: Nir Barzilai; P Cohen; R Bar-Illan; N McIntyre; Eddy Karnieli
Case report: increased insulin sensitivity in tumor hypoglycemia in a diabetic patient: glucose metabolism in tumor hypoglycemia.
The American journal of the medical sciences 1991;302(4):229-34.
1991: P Cohen; Nir Barzilai; A Lerman; H Harel; P Szylman; Eddy Karnieli
Insulin effects on glucose and potassium metabolism in vivo: evidence for selective insulin resistance in humans.
The Journal of clinical endocrinology and metabolism 1991;73(3):564-8.
1991: Leif C Groop; Nir Barzilai; K Ratheiser; Livio Luzi; E Wåhlin-Boll; A Melander; Ralph DeFronzo
Dose-dependent effects of glyburide on insulin secretion and glucose uptake in humans.
Diabetes care 1991;14(8):724-7.
1990: P Cohen; C Harel; Reuven Bergman; D Daoud; Z Pam; Nir Barzilai; Michal Armoni; Eddy Karnieli
Insulin resistance and acanthosis nigricans: evidence for a postbinding defect in vivo.
Metabolism: clinical and experimental 1990;39(10):1006-11.
1990: O M Shapira; S Pasik; J P Wassermann; Nir Barzilai; A Mashiah
Ultrasound screening for abdominal aortic aneurysms in patients with atherosclerotic peripheral vascular disease.
The Journal of cardiovascular surgery 1990;31(2):170-2.
1989: A Lifschitz; A Mavor; Y Gindin; Nir Barzilai; R Pfefferman
[Ectopic spleen syndrome].
Harefuah 1989;116(12):630-2.
1987: Nir Barzilai; A Moses; J Menczel
[Secondary Lyme's disease].
Harefuah 1987;113(1-2):13-5.
1987: E Mor; Nir Barzilai; E Mavor
[Symptomatic simple hepatic cyst].
Harefuah 1987;112(10):492-4.
1986: P Cohen; Nir Barzilai; R Bar-Ilan; K Yassin; Eddy Karnieli
Lack of suppression of insulin secretion by hyperinsulinemia in a patient with an insulinoma.
The Journal of clinical endocrinology and metabolism 1986;63(6):1411-3.
1986: P Cohen; Nir Barzilai; D Barzilai; Eddy Karnieli
Correlation between insulin clearance and insulin responsiveness: studies in normal, obese, hyperthyroid, and Cushing's syndrome patients.
Metabolism: clinical and experimental 1986;35(8):744-9.
1985: Eddy Karnieli; P Cohen; Nir Barzilai; Z Ish-Shalom; Michal Armoni; R Rafaelov; D Barzilai
Insulin resistance in Cushing's syndrome.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1985;17(10):518-21.
1985: Nir Barzilai; P Cohen; D Barzilai; Eddy Karnieli
Increased insulin responsiveness and insulin clearance in thyrotoxicosis.
Israel journal of medical sciences 1985;21(9):722-6.