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George Makhatadze
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Research Profile (preview)
Occupations
Disorders
Physiology
Procedures
Concepts & Ideas
Phenomena
Genes & Molecular Sequences
Chemicals & Drugs
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Network (preview)
14
Lopez, Maria
13
Privalov, Peter
13
Gribenko, Alexey
10
Loladze, Vakhtang
8
Richardson, John
7
Ermolenko, Dmitri
6
Thomas, Susan
4
Sanchez-Ruiz, Jose
4
Ibarra-Molero, Beatriz
3
Streicher, Werner
2
Tereshko, Valentina
2
Kossiakoff, Anthony
2
Lemaire, Stéphane
2
Kent, Stephen
2
Gronenborn, Angela
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Publications
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Geonetwork of George Makhatadze (preview)
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All Publications
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2009: Schweiker Katrina L; Fitz Victoria W; Makhatadze George I
Universal convergence of the specific volume changes of globular proteins upon unfolding.
Biochemistry 2009;48(46):10846-51.
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2009: Streicher Werner W; Lopez Maria M; Makhatadze George I
Annexin I and annexin II N-terminal peptides binding to S100 protein family members: specificity and thermodynamic characterization.
Biochemistry 2009;48(12):2788-98.
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2009: Gribenko Alexey V; Patel Mayank M; Liu Jiajing; McCallum Scott A; Wang Chunyu; Makhatadze George I
Rational stabilization of enzymes by computational redesign of surface charge-charge interactions.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2601-6.
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2009: Chung Wai Keen; Hou Ying; Freed Alexander; Holstein Melissa; Makhatadze George I; Cramer Steven M
Investigation of protein binding affinity and preferred orientations in ion exchange systems using a homologous protein library.
Biotechnology and bioengineering 2009;102(3):869-81.
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2009: Schweiker Katrina L; Makhatadze George I
A computational approach for the rational design of stable proteins and enzymes: optimization of surface charge-charge interactions.
Methods in enzymology 2009;454():175-211.
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2009: Schweiker Katrina L; Makhatadze George I
Protein stabilization by the rational design of surface charge-charge interactions.
Methods in molecular biology (Clifton, N.J.) 2009;490():261-83.
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2008: Gvritishvili Anzor G; Gribenko Alexey V; Makhatadze George I
Cooperativity of complex salt bridges.
Protein science : a publication of the Protein Society 2008;17(7):1285-90.
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2007: Schweiker Katrina L; Zarrine-Afsar Arash; Davidson Alan R; Makhatadze George I
Computational design of the Fyn SH3 domain with increased stability through optimization of surface charge charge interactions.
Protein science : a publication of the Protein Society 2007;16(12):2694-702.
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2007: Streicher Werner W; Makhatadze George I
Unfolding thermodynamics of Trp-cage, a 20 residue miniprotein, studied by differential scanning calorimetry and circular dichroism spectroscopy.
Biochemistry 2007;46(10):2876-80.
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2007: Ermolenko Dmitri N; Dangi Bindi; Gvritishvili Anzor; Gronenborn Angela M; Makhatadze George I
Elimination of the C-cap in ubiquitin - structure, dynamics and thermodynamic consequences.
Biophysical chemistry 2007;126(1-3):25-35.
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2007: Gribenko Alexey V; Makhatadze George I
Role of the charge-charge interactions in defining stability and halophilicity of the CspB proteins.
Journal of molecular biology 2007;366(3):842-56.
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2007: Streicher Werner W; Makhatadze George I
Advances in the analysis of conformational transitions in peptides using differential scanning calorimetry.
Methods in molecular biology (Clifton, N.J.) 2007;350():105-13.
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2006: Gribenko Alexey V; Keiffer Timothy R; Makhatadze George I
Amino acid substitutions affecting protein dynamics in eglin C do not affect heat capacity change upon unfolding.
Proteins 2006;64(2):295-300.
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2006: Strickler Samantha S; Gribenko Alexey V; Gribenko Alexander V; Keiffer Timothy R; Tomlinson Jessica; Reihle Tracey; Loladze Vakhtang V; Makhatadze George I
Protein stability and surface electrostatics: a charged relationship.
Biochemistry 2006;45(9):2761-6.
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2006: Bang Duhee; Gribenko Alexey V; Tereshko Valentina; Kossiakoff Anthony A; Kent Stephen B; Makhatadze George I
Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
Nature chemical biology 2006;2(3):139-43.
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2006: Streicher Werner W; Makhatadze George I
Calorimetric evidence for a two-state unfolding of the beta-hairpin peptide trpzip4.
Journal of the American Chemical Society 2006;128(1):30-1.
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2005: Lee Chi-Fung; Makhatadze George I; Wong Kam-Bo
Effects of charge-to-alanine substitutions on the stability of ribosomal protein L30e from Thermococcus celer.
Biochemistry 2005;44(51):16817-25.
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2005: Permyakov Serge E; Makhatadze George I; Owenius Rikard; Uversky Vladimir N; Brooks Charles L; Permyakov Eugene A; Berliner Lawrence J
How to improve nature: study of the electrostatic properties of the surface of alpha-lactalbumin.
Protein engineering, design & selection : PEDS 2005;18(9):425-33.
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2005: Bang Duhee; Makhatadze George I; Tereshko Valentina; Kossiakoff Anthony A; Kent Stephen B
Total chemical synthesis and X-ray crystal structure of a protein diastereomer: [D-Gln 35]ubiquitin.
Angewandte Chemie (International ed. in English) 2005;44(25):3852-6.
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2005: Richardson John M; Lopez Maria M; Makhatadze George I
Enthalpy of helix-coil transition: missing link in rationalizing the thermodynamics of helix-forming propensities of the amino acid residues.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1413-8.
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2005: Loladze Vakhtang V; Makhatadze George I
Both helical propensity and side-chain hydrophobicity at a partially exposed site in alpha-helix contribute to the thermodynamic stability of ubiquitin.
Proteins 2005;58(1):1-6.
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2005: Makhatadze George I
Thermodynamics Of alpha-Helix Formation.
Advances in protein chemistry 2005;72():199-226.
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2004: Lee Yi-Chien; Volk David E; Thiviyanathan Varatharasa; Kleerekoper Quinn; Gribenko Alexey V; Zhang Shanmin; Gorenstein David G; Makhatadze George I; Luxon Bruce A
NMR structure of the Apo-S100P protein.
Journal of biomolecular NMR 2004;29(3):399-402.
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2004: Makhatadze George I; Loladze Vakhtang V; Gribenko Alexey V; Lopez Maria M
Mechanism of thermostabilization in a designed cold shock protein with optimized surface electrostatic interactions.
Journal of molecular biology 2004;336(4):929-42.
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2004: Richardson John M; Makhatadze George I
Temperature dependence of the thermodynamics of helix-coil transition.
Journal of molecular biology 2004;335(4):1029-37.
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2003: Ermolenko Dmitri N; Richardson John M; Makhatadze George I
Noncharged amino acid residues at the solvent-exposed positions in the middle and at the C terminus of the alpha-helix have the same helical propensity.
Protein science : a publication of the Protein Society 2003;12(6):1169-76.
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2003: Makhatadze George I; Loladze Vakhtang V; Ermolenko Dmitri N; Chen XiaoFen; Thomas Susan T
Contribution of surface salt bridges to protein stability: guidelines for protein engineering.
Journal of molecular biology 2003;327(5):1135-48.
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2002: Ermolenko D N; Makhatadze G I
Bacterial cold-shock proteins.
Cellular and molecular life sciences : CMLS 2002;59(11):1902-13.
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2002: Ermolenko Dmitri N; Thomas Susan T; Aurora Rajeev; Gronenborn Angela M; Makhatadze George I
Hydrophobic interactions at the Ccap position of the C-capping motif of alpha-helices.
Journal of molecular biology 2002;322(1):123-35.
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2002: Loladze Vakhtang V; Ermolenko Dmitri N; Makhatadze George I
Thermodynamic consequences of burial of polar and non-polar amino acid residues in the protein interior.
Journal of molecular biology 2002;320(2):343-57.
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2002: Gribenko Alexey V; Guzmán-Casado Mercedes; Lopez Maria M; Makhatadze George I
Conformational and thermodynamic properties of peptide binding to the human S100P protein.
Protein science : a publication of the Protein Society 2002;11(6):1367-75.
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2002: Lopez Maria M; Chin Der-Hang; Baldwin Robert L; Makhatadze George I
The enthalpy of the alanine peptide helix measured by isothermal titration calorimetry using metal-binding to induce helix formation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1298-302.
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2002: Loladze Vakhtang V; Makhatadze George I
Removal of surface charge-charge interactions from ubiquitin leaves the protein folded and very stable.
Protein science : a publication of the Protein Society 2002;11(1):174-7.
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2002: Lopez Maria M; Makhatadze George I
Isothermal titration calorimetry.
Methods in molecular biology (Clifton, N.J.) 2002;173():121-6.
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2002: Lopez Maria M; Makhatadze George I
Differential scanning calorimetry.
Methods in molecular biology (Clifton, N.J.) 2002;173():113-9.
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2001: Gribenko A V; Hopper J E; Makhatadze G I
Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins.
Biochemistry 2001;40(51):15538-48.
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2001: Thomas S T; Loladze V V; Makhatadze G I
Hydration of the peptide backbone largely defines the thermodynamic propensity scale of residues at the C' position of the C-capping box of alpha-helices.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10670-5.
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2001: Loladze V V; Ermolenko D N; Makhatadze G I
Heat capacity changes upon burial of polar and nonpolar groups in proteins.
Protein science : a publication of the Protein Society 2001;10(7):1343-52.
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2001: Lopez M M; Yutani K; Makhatadze G I
Interactions of the cold shock protein CspB from Bacillus subtilis with single-stranded DNA. Importance of the T base content and position within the template.
The Journal of biological chemistry 2001;276(18):15511-8.
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2001: Brokx R D; Lopez M M; Vogel H J; Makhatadze G I
Energetics of target peptide binding by calmodulin reveals different modes of binding.
The Journal of biological chemistry 2001;276(17):14083-91.
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2001: Sanchez-Ruiz J M; Makhatadze G I
To charge or not to charge?
Trends in biotechnology 2001;19(4):132-5.
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2001: Ibarra-Molero B; Makhatadze G I; Matthews C R
Mapping the energy surface for the folding reaction of the coiled-coil peptide GCN4-p1.
Biochemistry 2001;40(3):719-31.
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2000: Richardson J M; Lemaire S D; Jacquot J P; Makhatadze G I
Difference in the mechanisms of the cold and heat induced unfolding of thioredoxin h from Chlamydomonas reinhardtii: spectroscopic and calorimetric studies.
Biochemistry 2000;39(36):11154-62.
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2000: Thomas S T; Makhatadze G I
Contribution of the 30/36 hydrophobic contact at the C-terminus of the alpha-helix to the stability of the ubiquitin molecule.
Biochemistry 2000;39(33):10275-83.
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2000: Lopez M M; Makhatadze G I
Major cold shock proteins, CspA from Escherichia coli and CspB from Bacillus subtilis, interact differently with single-stranded DNA templates.
Biochimica et biophysica acta 2000;1479(1-2):196-202.
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2000: Petrosian S A; Makhatadze G I
Contribution of proton linkage to the thermodynamic stability of the major cold-shock protein of Escherichia coli CspA.
Protein science : a publication of the Protein Society 2000;9(2):387-94.
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2000: Lemaire S D; Richardson J M; Goyer A; Keryer E; Lancelin J M; Makhatadze G I; Jacquot J P
Primary structure determinants of the pH- and temperature-dependent aggregation of thioredoxin.
Biochimica et biophysica acta 2000;1476(2):311-23.
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1999: Loladze V V; Ibarra-Molero B; Sanchez-Ruiz J M; Makhatadze G I
Engineering a thermostable protein via optimization of charge-charge interactions on the protein surface.
Biochemistry 1999;38(50):16419-23.
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1999: Lopez M M; Yutani K; Makhatadze G I
Interactions of the major cold shock protein of Bacillus subtilis CspB with single-stranded DNA templates of different base composition.
The Journal of biological chemistry 1999;274(47):33601-8.
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1999: Richardson J M; McMahon K W; MacDonald C C; Makhatadze G I
MEARA sequence repeat of human CstF-64 polyadenylation factor is helical in solution. A spectroscopic and calorimetric study.
Biochemistry 1999;38(39):12869-75.
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1999: Pace C N; Grimsley G R; Thomas S T; Makhatadze G I
Heat capacity change for ribonuclease A folding.
Protein science : a publication of the Protein Society 1999;8(7):1500-4.
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1999: Ibarra-Molero B; Loladze V V; Makhatadze G I; Sanchez-Ruiz J M
Thermal versus guanidine-induced unfolding of ubiquitin. An analysis in terms of the contributions from charge-charge interactions to protein stability.
Biochemistry 1999;38(25):8138-49.
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1999: Ibarra-Molero B; Makhatadze G I; Sanchez-Ruiz J M
Cold denaturation of ubiquitin.
Biochimica et biophysica acta 1999;1429(2):384-90.
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1998: Gribenko A V; Makhatadze G I
Oligomerization and divalent ion binding properties of the S100P protein: a Ca2+/Mg2+-switch model.
Journal of molecular biology 1998;283(3):679-94.
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1998: Lopez M M; Makhatadze G I
Solvent isotope effect on thermodynamics of hydration.
Biophysical chemistry 1998;74(2):117-25.
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1998: Makhatadze G I
Heat capacities of amino acids, peptides and proteins.
Biophysical chemistry 1998;71(2-3):133-56.
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1998: Makhatadze G I; Lopez M M; Richardson J M; Thomas S T
Anion binding to the ubiquitin molecule.
Protein science : a publication of the Protein Society 1998;7(3):689-97.
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1998: Gribenko A; Lopez M M; Richardson J M; Makhatadze G I
Cloning, overexpression, purification, and spectroscopic characterization of human S100P.
Protein science : a publication of the Protein Society 1998;7(1):211-5.
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1997: Makhatadze G I; Lopez M M; Privalov P L
Heat capacities of protein functional groups.
Biophysical chemistry 1997;64(1-3):93-101.
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1996: Makhatadze G I; Privalov P L
On the entropy of protein folding.
Protein science : a publication of the Protein Society 1996;5(3):507-10.
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1995: Makhatadze G I; Clore G M; Gronenborn A M
Solvent isotope effect and protein stability.
Nature structural biology 1995;2(10):852-5.
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1995: Makhatadze G I; Privalov P L
Energetics of protein structure.
Advances in protein chemistry 1995;47():307-425.
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1994: Makhatadze G I; Marahiel M A
Effect of pH and phosphate ions on self-association properties of the major cold-shock protein from Bacillus subtilis.
Protein science : a publication of the Protein Society 1994;3(11):2144-7.
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1994: Makhatadze G I; Clore G M; Gronenborn A M; Privalov P L
Thermodynamics of unfolding of the all beta-sheet protein interleukin-1 beta.
Biochemistry 1994;33(31):9327-32.
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1994: Makhatadze G I; Privalov P L
Hydration effects in protein unfolding.
Biophysical chemistry 1994;51(2-3):291-304; discussion 304-9.
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1994: Makhatadze G I; Privalov P L
Energetics of interactions of aromatic hydrocarbons with water.
Biophysical chemistry 1994;50(3):285-91.
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1994: Griko Y V; Makhatadze G I; Privalov P L; Hartley R W
Thermodynamics of barnase unfolding.
Protein science : a publication of the Protein Society 1994;3(4):669-76.
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1994: Wintrode P L; Makhatadze G I; Privalov P L
Thermodynamics of ubiquitin unfolding.
Proteins 1994;18(3):246-53.
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1994: Yu Y; Makhatadze G I; Pace C N; Privalov P L
Energetics of ribonuclease T1 structure.
Biochemistry 1994;33(11):3312-9.
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1993: Makhatadze G I; Kim K S; Woodward C; Privalov P L
Thermodynamics of BPTI folding.
Protein science : a publication of the Protein Society 1993;2(12):2028-36.
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1993: Privalov P L; Makhatadze G I
Contribution of hydration to protein folding thermodynamics. II. The entropy and Gibbs energy of hydration.
Journal of molecular biology 1993;232(2):660-79.
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1993: Makhatadze G I; Privalov P L
Contribution of hydration to protein folding thermodynamics. I. The enthalpy of hydration.
Journal of molecular biology 1993;232(2):639-59.
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1992: Makhatadze G I; Privalov P L
Protein interactions with urea and guanidinium chloride. A calorimetric study.
Journal of molecular biology 1992;226(2):491-505.
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1992: Privalov P L; Makhatadze G I
Contribution of hydration and non-covalent interactions to the heat capacity effect on protein unfolding.
Journal of molecular biology 1992;224(3):715-23.
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