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Ajoy Basak

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Chemicals & Drugs

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Amino Acid Sequences

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Catherine A Goubko; Harold Jarrell; Swapan Majumdar; Nam Huan Khieu; Ajoy Basak; Xudong Cao
Comparative analysis of photocaged RGDS peptides for cell patterning.
Majambu Mbikay; Kabwe K Nkongolo; Francine Sirois; Ajoy Basak; Michel Chrétien
Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity.
Sitthichai Iamsaard; Arpornrad Saewu; Nopparat Srakaew; Ajoy Basak; Greanggrai Hommalai; Rapeepun Vanichviriyakit; Boonsirm Withyachumnarnkul; Nongnuj Tanphaichitr
Enzymatic activity of sperm proprotein convertase is important for mammalian fertilization.

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All Publications

2013: Catherine A Goubko; Harold Jarrell; Swapan Majumdar; Nam Huan Khieu; Ajoy Basak; Xudong Cao
Comparative analysis of photocaged RGDS peptides for cell patterning.
Journal of biomedical materials research. Part A 2013;101(3):787-96.
2011: Majambu Mbikay; Kabwe K Nkongolo; Francine Sirois; Ajoy Basak; Michel Chrétien
Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity.
Molecular genetics and metabolism 2011;104(4):682-7.
2011: Sitthichai Iamsaard; Arpornrad Saewu; Nopparat Srakaew; Ajoy Basak; Greanggrai Hommalai; Rapeepun Vanichviriyakit; Boonsirm Withyachumnarnkul; Nongnuj Tanphaichitr
Enzymatic activity of sperm proprotein convertase is important for mammalian fertilization.
Journal of cellular physiology 2011;226(11):2817-26.
2011: E Zhao; Ajoy Basak; Reiner Fischer-Colbrie; Alan S McNeilly; Judy R McNeilly; Jae Young Seong; Vance L Trudeau
Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.
American journal of physiology. Endocrinology and metabolism 2011;301(2):E288-97.
2010: E Zhao; Caleb L Grey; Dapeng Zhang; Jan A Mennigen; Ajoy Basak; John P Chang; Vance L Trudeau
Secretoneurin is a potential paracrine factor from lactotrophs stimulating gonadotropin release in the goldfish pituitary.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;299(5):R1290-7.
2010: Catherine A Goubko; Swapan Majumdar; Ajoy Basak; Xudong Cao
Hydrogel cell patterning incorporating photocaged RGDS peptides.
Biomedical microdevices 2010;12(3):555-68.
2009: E Zhao; Dapeng Zhang; Ajoy Basak; Vance L Trudeau
New insights into granin-derived peptides: evolution and endocrine roles.
General and comparative endocrinology 2009;164(2-3):161-74.
2009: Mohamed Ouardouz; Elaine Coderre; Ajoy Basak; Andrew Chen; Gerald W Zamponi; Shameed Hameed; Renata Rehak; Xinghua Yin; Bruce D Trapp; Peter K Stys
Glutamate receptors on myelinated spinal cord axons: I. GluR6 kainate receptors.
Annals of neurology 2009;65(2):151-9.
2008: Michel Chrétien; Nabil G Seidah; Ajoy Basak; Majambu Mbikay
Proprotein convertases as therapeutic targets.
Expert opinion on therapeutic targets 2008;12(10):1289-300.
2008: Nathalie Scamuffa; Geraldine Siegfried; Yannick Bontemps; Liming Ma; Ajoy Basak; Ghislaine Cherel; Fabien Calvo; Nabil G Seidah; Abdel-Majid Khatib
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
The Journal of clinical investigation 2008;118(1):352-63.
2007: Antonella Pasquato; Monica Dettin; Ajoy Basak; Roberta Gambaretto; L Tonin; Nabil G Seidah; Carlo Di Bello
Heparin enhances the furin cleavage of HIV-1 gp160 peptides.
FEBS letters 2007;581(30):5807-13.
2007: Arezu Jahani-Asl; Ajoy Basak; Benjamin K Tsang
Caspase-3-mediated cleavage of Akt: involvement of non-consensus sites and influence of phosphorylation.
FEBS letters 2007;581(16):2883-8.
2007: Ajoy Basak; Abhijit Mitra; Sarmistha Basak; Carolyn Pasko; Michel Chrétien; Pamela Seaton
A fluorogenic peptide containing the processing site of human SARS corona virus S-protein: kinetic evaluation and NMR structure elucidation.
Chembiochem : a European journal of chemical biology 2007;8(9):1029-37.
2006: E Zhao; Ajoy Basak; Vance L Trudeau
Secretoneurin stimulates goldfish pituitary luteinizing hormone production.
Neuropeptides 2006;40(4):275-82.
2006: E Zhao; Ajoy Basak; Kate Crump; Vance L Trudeau
Proteolytic processing and differential distribution of secretogranin-II in goldfish.
General and comparative endocrinology 2006;146(2):100-7.
2006: Xiaokui Yang; Michael Fraser; Ute M Moll; Ajoy Basak; Benjamin K Tsang
Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway.
Cancer research 2006;66(6):3126-36.
2005: Geraldine Siegfried; Ajoy Basak; Wendy Prichett-Pejic; Nathalie Scamuffa; Liming Ma; Suzanne Benjannet; John P Veinot; Fabien Calvo; Nabil G Seidah; Abdel-Majid Khatib
Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases.
Oncogene 2005;24(46):6925-35.
2005: Ajoy Basak; Farzaneh Lotfipour
Modulating furin activity with designed mini-PDX peptides: synthesis and in vitro kinetic evaluation.
FEBS letters 2005;579(21):4813-21.
2005: Qing Qiu; Ajoy Basak; Majambu Mbikay; Benjamin K Tsang; Andrée Gruslin
Role of pro-IGF-II processing by proprotein convertase 4 in human placental development.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):11047-52.
2005: Eric Bergeron; Martin J Vincent; Louise Wickham; Josée Hamelin; Ajoy Basak; Stuart T Nichol; Michel Chrétien; Nabil G Seidah
Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus.
Biochemical and biophysical research communications 2005;326(3):554-63.
2004: Marwan Samia; Katherine Larivière; M H Rochon; Edward O'Brien; Ajoy Basak; Vance L Trudeau
Seasonal cyclicity of secretogranin-II expression and its modulation by sex steroids and GnRH in the female goldfish pituitary.
General and comparative endocrinology 2004;139(3):198-205.
2004: Sarmistha Basak; Nicolas A Stewart; Michel Chrétien; Ajoy Basak
Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1.
FEBS letters 2004;573(1-3):186-94.
2004: Sarmistha Basak; Michel Chrétien; Majambu Mbikay; Ajoy Basak
In vitro elucidation of substrate specificity and bioassay of proprotein convertase 4 using intramolecularly quenched fluorogenic peptides.
The Biochemical journal 2004;380(Pt 2):505-14.
2003: Sylvie Lemonde; Gustavo Turecki; David Bakish; Lisheng Du; Pavel D Hrdina; Christopher D Bown; Pedro Adolfo Sequeira; Neena Kushwaha; Stephen J Morris; Ajoy Basak; Xiao-Ming Ou; Paul R Albert
Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(25):8788-99.
2003: Martin J Vincent; Angela J Sanchez; Bobbie R Erickson; Ajoy Basak; Michel Chretien; Nabil G Seidah; Stuart T Nichol
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.
Journal of virology 2003;77(16):8640-9.
2003: Eric Bergeron; Ajoy Basak; jeff Keyser; Nabil G Seidah
Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage.
The Biochemical journal 2003;373(Pt 2):475-84.
2003: Ajoy Basak; Claude Lazure
Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes.
The Biochemical journal 2003;373(Pt 1):231-9.
2003: Geraldine Siegfried; Ajoy Basak; James A Cromlish; Suzanne Benjannet; Jadwiga Marcinkiewicz; Michel Chrétien; Nabil G Seidah; Abdel-Majid Khatib
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
The Journal of clinical investigation 2003;111(11):1723-32.
2003: Nabil G Seidah; Suzanne Benjannet; Louise Wickham; Jadwiga Marcinkiewicz; Stephanie Belanger Jasmin; Stefano Stifani; Ajoy Basak; Annik Prat; Michel Chretien
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):928-33.
2002: Gilles Croissandeau; Ajoy Basak; Nabil G Seidah; Michel Chrétien; Majambu Mbikay
Proprotein convertases are important mediators of the adipocyte differentiation of mouse 3T3-L1 cells.
Journal of cell science 2002;115(Pt 6):1203-11.
2001: Suzanne Benjannet; A Elagoz; Louise Wickham; M Mamarbachi; JS Munzer; Ajoy Basak; Claude Lazure; James A Cromlish; Sangram S Sisodia; F Checler; Michel Chrétien; Nabil G Seidah
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.
The Journal of biological chemistry 2001;276(14):10879-87.
2001: Ajoy Basak; M Zhong; JS Munzer; Michel Chrétien; Nabil G Seidah
Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides.
The Biochemical journal 2001;353(Pt 3):537-45.
2000: Andréa Frota Ruchon; Mieczyslaw Marcinkiewicz; K Ellefsen; Ajoy Basak; J Aubin; Philippe Crine; Guy Boileau
Cellular localization of neprilysin in mouse bone tissue and putative role in hydrolysis of osteogenic peptides.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(7):1266-74.
2000: BB Touré; JS Munzer; Ajoy Basak; Suzanne Benjannet; J Rochemont; Claude Lazure; Michel Chrétien; Nabil G Seidah
Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment.
The Journal of biological chemistry 2000;275(4):2349-58.
1999: M Zhong; JS Munzer; Ajoy Basak; Suzanne Benjannet; SJ Mowla; jeff Keyser; Michel Chrétien; Nabil G Seidah
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity.
The Journal of biological chemistry 1999;274(48):33913-20.
1999: Nabil G Seidah; Suzanne Benjannet; Josée Hamelin; Aida M Mamarbachi; Ajoy Basak; Jadwiga Marcinkiewicz; Majambu Mbikay; Michel Chrétien; Mieczyslaw Marcinkiewicz
The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1.
Annals of the New York Academy of Sciences 1999;885():57-74.
1999: Ajoy Basak; BB Touré; Claude Lazure; Majambu Mbikay; Michel Chrétien; Nabil G Seidah
Enzymic characterization in vitro of recombinant proprotein convertase PC4.
The Biochemical journal 1999;343 Pt 1():29-37.
1999: C Rovère; José Luis; Jean-Claude Lissitzky; Ajoy Basak; Jacques Marvaldi; Michel Chrétien; Nabil G Seidah
The RGD motif and the C-terminal segment of proprotein convertase 1 are critical for its cellular trafficking but not for its intracellular binding to integrin alpha5beta1.
The Journal of biological chemistry 1999;274(18):12461-7.
1999: Nabil G Seidah; SJ Mowla; Josée Hamelin; Aida M Mamarbachi; Suzanne Benjannet; BB Touré; Ajoy Basak; JS Munzer; Jadwiga Marcinkiewicz; M Zhong; J C Barale; Claude Lazure; Richard A Murphy; Michel Chrétien; Mieczyslaw Marcinkiewicz
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1321-6.
1999: Ajoy Basak; S Cooper; A G Roberge; U K Banik; Michel Chrétien; Nabil G Seidah
Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters.
The Biochemical journal 1999;338 ( Pt 1)():107-13.
1998: Robert Day; Claude Lazure; Ajoy Basak; A Boudreault; P Limperis; Weijia Dong; Iris Lindberg
Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity.
The Journal of biological chemistry 1998;273(2):829-36.
1997: JS Munzer; Ajoy Basak; M Zhong; Aida M Mamarbachi; Josée Hamelin; D Savaria; Claude Lazure; G N Hendy; Suzanne Benjannet; Michel Chrétien; Nabil G Seidah
In vitro characterization of the novel proprotein convertase PC7.
The Journal of biological chemistry 1997;272(32):19672-81.
1997: Ajoy Basak; B Ernst; D Brewer; Nabil G Seidah; JS Munzer; Claude Lazure; Gilles Lajoie
Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1.
The journal of peptide research : official journal of the American Peptide Society 1997;49(6):596-603.
1995: Ajoy Basak; A Boudreault; A Chen; Michel Chrétien; Nabil G Seidah; Claude Lazure
Application of the multiple antigenic peptides (MAP) strategy to the production of prohormone convertases antibodies: synthesis, characterization and use of 8-branched immunogenic peptides.
Journal of peptide science : an official publication of the European Peptide Society 1995;1(6):385-95.
1995: Ajoy Basak; C Schmidt; A A Ismail; Nabil G Seidah; Michel Chrétien; Claude Lazure
Peptidyl substrates containing unnatural amino acid at the P'1 position are potent inhibitors of prohormone convertases.
International journal of peptide and protein research 1995;46(3-4):228-37.
1995: F Jean; A Boudreault; Ajoy Basak; Nabil G Seidah; Claude Lazure
Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor.
The Journal of biological chemistry 1995;270(33):19225-31.
1995: F Jean; Ajoy Basak; J DiMaio; Nabil G Seidah; Claude Lazure
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor.
The Biochemical journal 1995;307 ( Pt 3)():689-95.
1994: Ajoy Basak; F Jean; Nabil G Seidah; Claude Lazure
Design and synthesis of novel inhibitors of prohormone convertases.
International journal of peptide and protein research 1994;44(3):253-61.
1994: Ajoy Basak; F Jean; H Dugas; Claude Lazure
Biotinylation of an enkephalin-containing heptapeptide via various spacer arms. Synthesis, comparative binding studies toward avidin, and application as substrates in enzymatic reactions.
Bioconjugate chemistry 1994;5(4):301-5.
1994: jeff Keyser; Michel Vandenbranden; Jean-Marie Ruysschaert; J Cogniaux; Gary S Jacob; Carol Howard; G Marshall; A Kompelli; Ajoy Basak; F Jean
The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM).
The Journal of biological chemistry 1994;269(16):12240-7.
1993: F Jean; Ajoy Basak; N Rondeau; Suzanne Benjannet; Geoffrey N Hendy; Nabil G Seidah; Michel Chrétien; Claude Lazure
Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells.
The Biochemical journal 1993;292 ( Pt 3)():891-900.
1993: Ajoy Basak; A Boudreault; F Jean; Michel Chrétien; Claude Lazure
Radiolabeled biotinyl peptides as useful reagents for the study of proteolytic enzymes.
Analytical biochemistry 1993;209(2):306-14.
1991: F Brisse; M G Simard; H Dugas; Ajoy Basak
Structure of a psoralen derivative of a monosubstituted 18-crown-6 ether.
Acta crystallographica. Section C, Crystal structure communications 1991;47 ( Pt 8)():1683-7.
1991: F Jean; Ajoy Basak; Michel Chrétien; Claude Lazure
Detection of endopeptidase activity and analysis of cleavage specificity using a radiometric solid-phase enzymatic assay.
Analytical biochemistry 1991;194(2):399-406.
1990: Ajoy Basak; Y T Gong; J A Cromlish; J A Paquin; F Jean; Nabil G Seidah; Claude Lazure; Michel Chrétien
Syntheses of argininal semicarbazone containing peptides and their applications in the affinity chromatography of serine proteinases.
International journal of peptide and protein research 1990;36(1):7-17.