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Alexandros Makriyannis

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
18
Thakur, Ganesh
17
Järbe, Torbjörn
16
Mavromoustakos, Thomas
15
Khanolkar, Atmaram
15
Fan, Pusheng
13
Lin, Sonyuan
11
Janero, David
11
Salamone, John
11
Gatley, John
10
Xie, Xiang-Qun
9
Volkow, Nora
9
Gifford, Andrew
9
Nikas, Spyros
8
Piomelli, Daniele
8
Lamb, Richard

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Publications

TOP 3
Storr Martin A; Keenan Catherine M; Zhang Hong; Patel Kamala D; Makriyannis Alexandros; Sharkey Keith A
Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis.
Sink K S; Segovia K N; Nunes E J; Collins L E; Vemuri V K; Thakur G; Makriyannis A; Salamone J D
Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats.
Tiburu Elvis K; Gulla Stefano V; Tiburu Mark; Janero David R; Budil David E; Makriyannis Alexandros
Dynamic conformational responses of a human cannabinoid receptor-1 helix domain to its membrane environment.

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All Publications

2009: Storr Martin A; Keenan Catherine M; Zhang Hong; Patel Kamala D; Makriyannis Alexandros; Sharkey Keith A
Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis.
Inflammatory bowel diseases 2009;15(11):1678-85.
2009: Sink K S; Segovia K N; Nunes E J; Collins L E; Vemuri V K; Thakur G; Makriyannis A; Salamone J D
Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats.
Psychopharmacology 2009;206(2):223-32.
2009: Tiburu Elvis K; Gulla Stefano V; Tiburu Mark; Janero David R; Budil David E; Makriyannis Alexandros
Dynamic conformational responses of a human cannabinoid receptor-1 helix domain to its membrane environment.
Biochemistry 2009;48(22):4895-904.
2009: Tiburu Elvis K; Tyukhtenko Sergiy; Deshmukh Lalit; Vinogradova Olga; Janero David R; Makriyannis Alexandros
Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments.
Biochemical and biophysical research communications 2009;384(2):243-8.
2009: Tiburu Elvis K; Bowman Anna L; Struppe Jochem O; Janero David R; Avraham Hava K; Makriyannis Alexandros
Solid-state NMR and molecular dynamics characterization of cannabinoid receptor-1 (CB1) helix 7 conformational plasticity in model membranes.
Biochimica et biophysica acta 2009;1788(5):1159-67.
2009: Janero David R; Vadivel Subramanian K; Makriyannis Alexandros
Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: drug-discovery strategies.
International review of psychiatry (Abingdon, England) 2009;21(2):122-33.
2009: Järbe Torbjörn U C; Li Chen; Liu Qian; Makriyannis Alexandros
Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog.
Psychopharmacology 2009;203(2):229-39.
2009: Janero David R; Makriyannis Alexandros
Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis.
Expert opinion on emerging drugs 2009;14(1):43-65.
2009: Kunos George; Osei-Hyiaman Douglas; Bátkai Sándor; Sharkey Keith A; Makriyannis Alexandros
Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?
Trends in pharmacological sciences 2009;30(1):1-7.
2008: Pei Ying; Mercier Richard W; Anday Jenine K; Thakur Ganesh A; Zvonok Alexander M; Hurst Dow; Reggio Patricia H; Janero David R; Makriyannis Alexandros
Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation.
Chemistry & biology 2008;15(11):1207-19.
2008: Lu Tzong-Shi; Avraham Hava Karsenty; Seng Seyha; Tachado Souvenir D; Koziel Henry; Makriyannis Alexandros; Avraham Shalom
Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6406-16.
2008: Guo Jianxin; Yang De-Ping; Chari Ravi; Tian Xiaoyu; Pavlopoulos Spiro; Lu Dai; Makriyannis Alexandros
Magnetically aligned bicelles to study the orientation of lipophilic ligands in membrane bilayers.
Journal of medicinal chemistry 2008;51(21):6793-9.
2008: Yao Fenmei; Li Chen; Vadivel Subramanian K; Bowman Anna L; Makriyannis Alexandros
Development of novel tail-modified anandamide analogs.
Bioorganic & medicinal chemistry letters 2008;18(22):5912-5.
2008: Rahn Elizabeth J; Zvonok Alexander M; Thakur Ganesh A; Khanolkar Atmaram D; Makriyannis Alexandros; Hohmann Andrea G
Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats.
The Journal of pharmacology and experimental therapeutics 2008;327(2):584-91.
2008: Järbe T U C; LeMay B J; Olszewska T; Vemuri V K; Wood J T; Makriyannis A
Intrinsic effects of AM4113, a putative neutral CB1 receptor selective antagonist, on open-field behaviors in rats.
Pharmacology, biochemistry, and behavior 2008;91(1):84-90.
2008: Hodge Janel; Bow Joshua P; Plyler Kimberly S; Vemuri V Kiran; Wisniecki Ania; Salamone John D; Makriyannis Alexandros; McLaughlin Peter J
The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats.
Behavioural brain research 2008;193(2):298-305.
2008: Lu Dai; Guo Jianxin; Duclos Richard I; Bowman Anna L; Makriyannis Alexandros
Bornyl- and isobornyl-Delta8-tetrahydrocannabinols: a novel class of cannabinergic ligands.
Journal of medicinal chemistry 2008;51(20):6393-9.
2008: Magrioti Victoria; Naxakis George; Hadjipavlou-Litina Dimitra; Makriyannis Alexandros; Kokotos George
A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity.
Bioorganic & medicinal chemistry letters 2008;18(20):5424-7.
2008: Zvonok Nikolai; Pandarinathan Lakshmipathi; Williams John; Johnston Meghan; Karageorgos Ioannis; Janero David R; Krishnan Srinivasan C; Makriyannis Alexandros
Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis.
Chemistry & biology 2008;15(8):854-62.
2008: Järbe Torbjörn U C; Li Chen; Vadivel Subramanian K; Makriyannis Alexandros
Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.
Psychopharmacology 2008;198(4):467-78.
2008: Zvonok Nikolai; Williams John; Johnston Meghan; Pandarinathan Lakshmipathi; Janero David R; Li Jing; Krishnan Srinivasan C; Makriyannis Alexandros
Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification.
Journal of proteome research 2008;7(5):2158-64.
2008: Kapur Ankur; Samaniego Patrick; Thakur Ganesh A; Makriyannis Alexandros; Abood Mary E
Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction.
The Journal of pharmacology and experimental therapeutics 2008;325(1):341-8.
2008: Vemuri V Kiran; Janero David R; Makriyannis Alexandros
Pharmacotherapeutic targeting of the endocannabinoid signaling system: drugs for obesity and the metabolic syndrome.
Physiology & behavior 2008;93(4-5):671-86.
2008: Sink K S; Vemuri V K; Olszewska T; Makriyannis A; Salamone J D
Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior.
Psychopharmacology 2008;196(4):565-74.
2008: Sink Kelly S; McLaughlin Peter J; Wood Jodi Anne T; Brown Cara; Fan Pusheng; Vemuri V Kiran; Peng Yan; Olszewska Teresa; Thakur Ganesh A; Makriyannis Alex; Parker Linda A; Salamone John D
The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(4):946-55.
2008: Scherma Maria; Medalie Julie; Fratta Walter; Vadivel Subramanian K; Makriyannis Alexandros; Piomelli Daniele; Mikics Eva; Haller Jozsef; Yasar Sevil; Tanda Gianluigi; Goldberg Steven R
The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition.
Neuropharmacology 2008;54(1):129-40.
2008: Wood JodiAnne T; Williams John S; Pandarinathan Lakshmipathi; Courville Amber; Keplinger Melissa R; Janero David R; Vouros Paul; Makriyannis Alexandros; Lammi-Keefe Carol J
Comprehensive profiling of the human circulating endocannabinoid metabolome: clinical sampling and sample storage parameters.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(9):1289-95.
2007: Khanolkar Atmaram D; Lu Dai; Ibrahim Mohab; Duclos Richard I; Thakur Ganesh A; Malan T Phillip; Porreca Frank; Veerappan Vijayabaskar; Tian Xiaoyu; George Clifford; Parrish Damon A; Papahatjis Demetris P; Makriyannis Alexandros
Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity.
Journal of medicinal chemistry 2007;50(26):6493-500.
2007: Chambers Adam P; Vemuri V Kiran; Peng Yan; Wood Jodianne T; Olszewska Teresa; Pittman Quentin J; Makriyannis Alexandros; Sharkey Keith A
A neutral CB1 receptor antagonist reduces weight gain in rat.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(6):R2185-93.
2007: Järbe Torbjörn U C; DiPatrizio Nicholas V; Li Chen; Makriyannis Alexandros
Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats.
Behavioural pharmacology 2007;18(7):673-80.
2007: Vadivel Subramanian K; Vardarajan Sundararaman; Duclos Richard I; Wood JodiAnne T; Guo Jianxin; Makriyannis Alexandros
Conformationally constrained analogues of 2-arachidonoylglycerol.
Bioorganic & medicinal chemistry letters 2007;17(21):5959-63.
2007: Rahn E J; Makriyannis A; Hohmann A G
Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.
British journal of pharmacology 2007;152(5):765-77.
2007: Janero David R; Makriyannis Alexandros
Targeted modulators of the endogenous cannabinoid system: future medications to treat addiction disorders and obesity.
Current psychiatry reports 2007;9(5):365-73.
2007: Karanian David A; Karim Sanjida L; Wood JodiAnne T; Williams John S; Lin Sonyuan; Makriyannis Alexandros; Bahr Ben A
Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage.
The Journal of pharmacology and experimental therapeutics 2007;322(3):1059-66.
2007: Papahatjis Demetris P; Nahmias Victoria R; Nikas Spyros P; Andreou Thanos; Alapafuja Shakiru O; Tsotinis Andrew; Guo Jianxin; Fan Pusheng; Makriyannis Alexandros
C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols.
Journal of medicinal chemistry 2007;50(17):4048-60.
2007: Williams John; Wood JodiAnne; Pandarinathan Lakshmipathi; Karanian David A; Bahr Ben A; Vouros Paul; Makriyannis Alexandros
Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS.
Analytical chemistry 2007;79(15):5582-93.
2007: Salamone John D; McLaughlin Peter J; Sink Kelly; Makriyannis Alexandros; Parker Linda A
Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions.
Physiology & behavior 2007;91(4):383-8.
2007: Zvonok Nikolai; Yaddanapudi Suma; Williams John; Dai Shujia; Dong Keling; Rejtar Tomas; Karger Barry L; Makriyannis Alexandros
Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor.
Journal of proteome research 2007;6(6):2068-79.
2007: Kapur Ankur; Hurst Dow P; Fleischer Daniel; Whitnell Rob; Thakur Ganesh A; Makriyannis Alexandros; Reggio Patricia H; Abood Mary E
Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.
Molecular pharmacology 2007;71(6):1512-24.
2007: Solinas Marcello; Tanda Gianluigi; Justinova Zuzana; Wertheim Carrie E; Yasar Sevil; Piomelli Daniele; Vadivel Subramanian K; Makriyannis Alexandros; Goldberg Steven R
The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport.
The Journal of pharmacology and experimental therapeutics 2007;321(1):370-80.
2007: Gutierrez T; Farthing J N; Zvonok A M; Makriyannis A; Hohmann A G
Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis.
British journal of pharmacology 2007;150(2):153-63.
2007: Jiang Shuxian; Fu Yigong; Williams John; Wood Jodianne; Pandarinathan Lakshmipathi; Avraham Shiri; Makriyannis Alexandros; Avraham Shalom; Avraham Hava Karsenty
Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.
PloS one 2007;2(7):e641.
2006: Järbe Torbjörn U C; Lamb Richard J; Liu Qian; Makriyannis Alexandros
Discriminative stimulus functions of AM-1346, a CB1R selective anandamide analog in rats trained with Delta9-THC or (R)-methanandamide (AM-356).
Psychopharmacology 2006;188(3):315-23.
2006: Koufaki Maria; Kiziridi Christina; Papazafiri Panagiota; Vassilopoulos Athanasios; Varró Andràs; Nagy Zsolt; Farkas Attila; Makriyannis Alexandros
Synthesis and biological evaluation of benzopyran analogues bearing class III antiarrhythmic pharmacophores.
Bioorganic & medicinal chemistry 2006;14(19):6666-78.
2006: Järbe T U C; Ross T; DiPatrizio N V; Pandarinathan L; Makriyannis A
Effects of the CB1R agonist WIN-55,212-2 and the CB1R antagonists SR-141716 and AM-1387: open-field examination in rats.
Pharmacology, biochemistry, and behavior 2006;85(1):243-52.
2006: Kim Kathline; Moore Dan H; Makriyannis Alexandros; Abood Mary E
AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis.
European journal of pharmacology 2006;542(1-3):100-5.
2006: Dhawan Jasbeer; Deng Hongfeng; Gatley S John; Makriyannis Alexandros; Akinfeleye Tolulope; Bruneus Magalie; Dimaio Alexis A; Gifford Andrew N
Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[125/131I]AM2233.
Synapse (New York, N.Y.) 2006;60(2):93-101.
2006: Ibrahim Mohab M; Rude Megan L; Stagg Nicola J; Mata Heriberto P; Lai Josephine; Vanderah Todd W; Porreca Frank; Buckley Nancy E; Makriyannis Alexandros; Malan T Philip
CB2 cannabinoid receptor mediation of antinociception.
Pain 2006;122(1-2):36-42.
2006: Bahr Ben A; Karanian David A; Makanji Sagar S; Makriyannis Alexandros
Targeting the endocannabinoid system in treating brain disorders.
Expert opinion on investigational drugs 2006;15(4):351-65.
2006: McLaughlin Peter J; Qian Liu; Wood JodiAnne T; Wisniecki Ania; Winston Keisha M; Swezey Lynn A; Ishiwari Keita; Betz Adrienne J; Pandarinathan Lakshmipathi; Xu Wei; Makriyannis Alexandros; Salamone John D
Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/inverse agonist AM 1387.
Pharmacology, biochemistry, and behavior 2006;83(3):396-402.
2006: Papahatjis Demetris P; Nahmias Victoria R; Andreou Thanos; Fan Pusheng; Makriyannis Alexandros
Structural modifications of the cannabinoid side chain towards C3-aryl and 1',1'-cycloalkyl-1'-cyano cannabinoids.
Bioorganic & medicinal chemistry letters 2006;16(6):1616-20.
2006: Chen Jian-Zhong; Han Xiu-Wen; Liu Qian; Makriyannis Alexandros; Wang Junmei; Xie Xiang-Qun
3D-QSAR studies of arylpyrazole antagonists of cannabinoid receptor subtypes CB1 and CB2. A combined NMR and CoMFA approach.
Journal of medicinal chemistry 2006;49(2):625-36.
2006: Järbe Torbjörn U C; Liu Quian; Makriyannis Alexandros
Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats.
Psychopharmacology 2006;184(1):36-45.
2006: Williams John; Pandarinathan Lakshmipathi; Wood JodiAnne; Vouros Paul; Makriyannis Alexandros
Endocannabinoid metabolomics: a novel liquid chromatography-mass spectrometry reagent for fatty acid analysis.
The AAPS journal 2006;8(4):E655-60.
2006: Lu Dai; Vemuri V Kiran; Duclos Richard I; Makriyannis Alexandros
The cannabinergic system as a target for anti-inflammatory therapies.
Current topics in medicinal chemistry 2006;6(13):1401-26.
2006: Pavlopoulos Spiro; Thakur Ganesh A; Nikas Spyros P; Makriyannis Alexandros
Cannabinoid receptors as therapeutic targets.
Current pharmaceutical design 2006;12(14):1751-69.
2006: Thakur Ganesh A; Nikas Spyros P; Duclos Richard I; Makriyannis Alexandros
Methods for the synthesis of cannabinergic ligands.
Methods in molecular medicine 2006;123():113-48.
2005: Thakur Ganesh A; Duclos Richard I; Makriyannis Alexandros
Natural cannabinoids: templates for drug discovery.
Life sciences 2005;78(5):454-66.
2005: Picone Robert P; Khanolkar Atmaram D; Xu Wei; Ayotte Lionel A; Thakur Ganesh A; Hurst Dow P; Abood Mary E; Reggio Patricia H; Fournier Donna J; Makriyannis Alexandros
(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor.
Molecular pharmacology 2005;68(6):1623-35.
2005: Solinas Marcello; Panlilio Leigh V; Tanda Gianluigi; Makriyannis Alexandros; Matthews Stephanie A; Goldberg Steven R
Cannabinoid agonists but not inhibitors of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(11):2046-57.
2005: Van Sickle Marja D; Duncan Marnie; Kingsley Philip J; Mouihate Abdeslam; Urbani Paolo; Mackie Ken; Stella Nephi; Makriyannis Alexandros; Piomelli Daniele; Davison Joseph S; Marnett Lawrence J; Di Marzo Vincenzo; Pittman Quentin J; Patel Kamala D; Sharkey Keith A
Identification and functional characterization of brainstem cannabinoid CB2 receptors.
Science (New York, N.Y.) 2005;310(5746):329-32.
2005: Li Chen; Xu Wei; Vadivel Subramanian K; Fan Pusheng; Makriyannis Alexandros
High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor.
Journal of medicinal chemistry 2005;48(20):6423-9.
2005: Deng Hongfeng; Gifford Andrew N; Zvonok Alexander M; Cui Guangjian; Li Xiuyan; Fan Pusheng; Deschamps Jeffrey R; Flippen-Anderson Judith L; Gatley S John; Makriyannis Alexandros
Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.
Journal of medicinal chemistry 2005;48(20):6386-92.
2005: McLaughlin P J; Brown C M; Winston K M; Thakur G; Lu D; Makriyannis A; Salamone J D
The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats.
Behavioural pharmacology 2005;16(5-6):477-86.
2005: Makriyannis Alexandros; Tian Xiaoyu; Guo Jianxin
How lipophilic cannabinergic ligands reach their receptor sites.
Prostaglandins & other lipid mediators 2005;77(1-4):210-8.
2005: Xu W; Filppula S A; Mercier R; Yaddanapudi S; Pavlopoulos S; Cai J; Pierce W M; Makriyannis A
Purification and mass spectroscopic analysis of human CB1 cannabinoid receptor functionally expressed using the baculovirus system.
The journal of peptide research : official journal of the American Peptide Society 2005;66(3):138-50.
2005: Woelkart Karin; Xu Wei; Pei Ying; Makriyannis Alexandros; Picone Robert P; Bauer Rudolf
The endocannabinoid system as a target for alkamides from Echinacea angustifolia roots.
Planta medica 2005;71(8):701-5.
2005: Karanian David A; Brown Queenie B; Makriyannis Alexandros; Kosten Therese A; Bahr Ben A
Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(34):7813-20.
2005: Souli Charikleia; Avlonitis Nicolaos; Calogeropoulou Theodora; Tsotinis Andrew; Maksay Gábor; Bíró Tímea; Politi Aggeliki; Mavromoustakos Thomas; Makriyannis Alexandros; Reis Heribert; Papadopoulos Manthos
Novel 17beta-substituted conformationally constrained neurosteroids that modulate GABA A receptors.
Journal of medicinal chemistry 2005;48(16):5203-14.
2005: Tian Xiaoyu; Guo Jianxin; Yao Fenmei; Yang De-Ping; Makriyannis Alexandros
The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer.
The Journal of biological chemistry 2005;280(33):29788-95.
2005: Makriyannis Alexandros; Guo Jianxin; Tian Xiaoyu
Albumin enhances the diffusion of lipophilic drugs into the membrane bilayer.
Life sciences 2005;77(14):1605-11.
2005: Thakur Ganesh A; Nikas Spyros P; Makriyannis Alexandros
CB1 cannabinoid receptor ligands.
Mini reviews in medicinal chemistry 2005;5(7):631-40.
2005: Lu Dai; Meng Zhaoxing; Thakur Ganesh A; Fan Pusheng; Steed John; Tartal Cindy L; Hurst Dow P; Reggio Patricia H; Deschamps Jeffrey R; Parrish Damon A; George Clifford; Järbe Torbjörn U C; Lamb Richard J; Makriyannis Alexandros
Adamantyl cannabinoids: a novel class of cannabinergic ligands.
Journal of medicinal chemistry 2005;48(14):4576-85.
2005: McLaughlin P J; Winston K M; Limebeer C L; Parker L A; Makriyannis A; Salamone J D
The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats.
Psychopharmacology 2005;180(2):286-93.
2005: Makriyannis Alexandros; Mechoulam Raphael; Piomelli Daniele
Therapeutic opportunities through modulation of the endocannabinoid system.
Neuropharmacology 2005;48(8):1068-71.
2005: McLaughlin Peter J; Lu Dai; Winston Keisha M; Thakur Ganesh; Swezey Lynn A; Makriyannis Alexandros; Salamone John D
Behavioral effects of the novel cannabinoid full agonist AM 411.
Pharmacology, biochemistry, and behavior 2005;81(1):78-88.
2005: Li Zizhong; Gifford Andrew; Liu Qian; Thotapally Rajesh; Ding Yu-Shin; Makriyannis Alexandros; Gatley S John
Candidate PET radioligands for cannabinoid CB1 receptors: [18F]AM5144 and related pyrazole compounds.
Nuclear medicine and biology 2005;32(4):361-6.
2005: Ibrahim Mohab M; Porreca Frank; Lai Josephine; Albrecht Phillip J; Rice Frank L; Khodorova Alla; Davar Gudarz; Makriyannis Alexandros; Vanderah Todd W; Mata Heriberto P; Malan T Philip
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3093-8.
2005: Choi Gregory; Guo Jianxin; Makriyannis Alexandros
The conformation of the cytoplasmic helix 8 of the CB1 cannabinoid receptor using NMR and circular dichroism.
Biochimica et biophysica acta 2005;1668(1):1-9.
2005: Karanian David A; Brown Queenie B; Makriyannis Alexandros; Bahr Ben A
Blocking cannabinoid activation of FAK and ERK1/2 compromises synaptic integrity in hippocampus.
European journal of pharmacology 2005;508(1-3):47-56.
2005: Thakur G A; Nikas S P; Li C; Makriyannis A
Structural requirements for cannabinoid receptor probes.
Handbook of experimental pharmacology 2005;(168):209-46.
2004: Filppula S; Yaddanapudi S; Mercier R; Xu W; Pavlopoulos S; Makriyannis A
Purification and mass spectroscopic analysis of human CB2 cannabinoid receptor expressed in the baculovirus system.
The journal of peptide research : official journal of the American Peptide Society 2004;64(6):225-36.
2004: Nackley A G; Zvonok A M; Makriyannis A; Hohmann A G
Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation.
Journal of neurophysiology 2004;92(6):3562-74.
2004: Järbe Torbjörn U C; Harris Michele Y; Li Chen; Liu Qian; Makriyannis Alexandros
Discriminative stimulus effects in rats of SR-141716 (rimonabant), a cannabinoid CB1 receptor antagonist.
Psychopharmacology 2004;177(1-2):35-45.
2004: Järbe T U C; DiPatrizio N V; Lu D; Makriyannis A
(-)-Adamantyl-delta8-tetrahydrocannabinol (AM-411), a selective cannabinoid CB1 receptor agonist: effects on open-field behaviors and antagonism by SR-141716 in rats.
Behavioural pharmacology 2004;15(7):517-21.
2004: Czoty Paul W; Ramanathan Chinnasamy R; Mutschler Nicole H; Makriyannis Alexandros; Bergman Jack
Drug discrimination in methamphetamine-trained monkeys: effects of monoamine transporter inhibitors.
The Journal of pharmacology and experimental therapeutics 2004;311(2):720-7.
2004: Czoty Paul W; Makriyannis Alexandros; Bergman Jack
Methamphetamine discrimination and in vivo microdialysis in squirrel monkeys.
Psychopharmacology 2004;175(2):170-8.
2004: Luk Terry; Jin Wenzhen; Zvonok Alexander; Lu Dai; Lin Xin-Zhong; Chavkin Charles; Makriyannis Alexandros; Mackie Ken
Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist.
British journal of pharmacology 2004;142(3):495-500.
2004: Hohmann Andrea G; Farthing Jesse N; Zvonok Alexander M; Makriyannis Alexandros
Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin.
The Journal of pharmacology and experimental therapeutics 2004;308(2):446-53.
2004: Arizzi M N; Cervone K M; Aberman J E; Betz A; Liu Q; Lin S; Makriyannis A; Salamone J D
Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide.
Life sciences 2004;74(8):1001-11.
2004: Nikas Spyros P; Grzybowska Jolanta; Papahatjis Demetris P; Charalambous Avgui; Banijamali Ali R; Chari Ravi; Fan Pusheng; Kourouli Therapia; Lin Sonyuan; Nitowski Albert J; Marciniak Gilbert; Guo Yan; Li Xiuyan; Wang Chia-Lin J; Makriyannis Alexandros
The role of halogen substitution in classical cannabinoids: a CB1 pharmacophore model.
The AAPS journal 2004;6(4):e30.
2003: McLaughlin P J; Winston K; Swezey L; Wisniecki A; Aberman J; Tardif D J; Betz A J; Ishiwari K; Makriyannis A; Salamone J D
The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats.
Behavioural pharmacology 2003;14(8):583-8.
2003: Koufaki Maria; Calogeropoulou Theodora; Rekka Eleni; Chryselis Michael; Papazafiri Panagiota; Gaitanaki Catherine; Makriyannis Alexandros
Bifunctional agents for reperfusion arrhythmias: novel hybrid vitamin E/class I antiarrhythmics.
Bioorganic & medicinal chemistry 2003;11(23):5209-19.
2003: Guo Jianxin; Pavlopoulos Spiro; Tian Xiaoyu; Lu Dai; Nikas Spyros P; Yang De-Ping; Makriyannis Alexandros
Conformational study of lipophilic ligands in phospholipid model membrane systems by solution NMR.
Journal of medicinal chemistry 2003;46(23):4838-46.
2003: Quartilho Aline; Mata Heriberto P; Ibrahim Mohab M; Vanderah Todd W; Porreca Frank; Makriyannis Alexandros; Malan T Philip
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors.
Anesthesiology 2003;99(4):955-60.
2003: Ibrahim Mohab M; Deng Hongfeng; Zvonok Alexander; Cockayne Debra A; Kwan Joyce; Mata Heriberto P; Vanderah Todd W; Lai Josephine; Porreca Frank; Makriyannis Alexandros; Malan T Philip
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10529-33.
2003: Järbe Torbjörn U C; DiPatrizio Nicholas V; Li Chen; Makriyannis Alexandros
The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats.
Pharmacology, biochemistry, and behavior 2003;75(4):809-21.
2003: Papahatjis Demetris P; Nikas Spyros P; Kourouli Therapia; Chari Ravi; Xu Wei; Pertwee Roger G; Makriyannis Alexandros
Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'.
Journal of medicinal chemistry 2003;46(15):3221-9.
2003: Järbe Torbjörn U C; Lamb Richard J; Liu Qian; Makriyannis Alexandros
(R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A.
European journal of pharmacology 2003;466(1-2):121-7.
2003: Lastres-Becker Isabel; de Miguel Rosario; De Petrocellis Luciano; Makriyannis Alexandros; Di Marzo Vincenzo; Fernández-Ruiz Javier
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.
Journal of neurochemistry 2003;84(5):1097-109.
2003: Avlonitis Nikos; Lekka Eleni; Detsi Anastasia; Koufaki Maria; Calogeropoulou Theodora; Scoulica Efi; Siapi Eleni; Kyrikou Ioanna; Mavromoustakos Thomas; Tsotinis Andrew; Grdadolnik Simona Golic; Makriyannis Alexandros
Antileishmanial ring-substituted ether phospholipids.
Journal of medicinal chemistry 2003;46(5):755-67.
2003: Malan T Philip; Ibrahim Mohab M; Lai Josephine; Vanderah Todd W; Makriyannis Alexandros; Porreca Frank
CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?
Current opinion in pharmacology 2003;3(1):62-7.
2003: Chu Chester; Ramamurthy Arun; Makriyannis Alexandros; Tius Marcus A
Synthesis of covalent probes for the radiolabeling of the cannabinoid receptor.
The Journal of organic chemistry 2003;68(1):55-61.
2003: Nackley A G; Makriyannis A; Hohmann A G
Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
Neuroscience 2003;119(3):747-57.
2002: Thakur Ganesh A; Palmer Sonya L; Harrington Paul E; Stergiades Ioanna A; Tius Marcus A; Makriyannis Alexandros
Enantiomeric resolution of a novel chiral cannabinoid receptor ligand.
Journal of biochemical and biophysical methods 2002;54(1-3):415-22.
2002: Malan T Philip; Ibrahim Mohab M; Vanderah Todd W; Makriyannis Alexandros; Porreca Frank
Inhibition of pain responses by activation of CB(2) cannabinoid receptors.
Chemistry and physics of lipids 2002;121(1-2):191-200.
2002: Gifford Andrew N; Makriyannis Alexandros; Volkow Nora D; Gatley S John
In vivo imaging of the brain cannabinoid receptor.
Chemistry and physics of lipids 2002;121(1-2):65-72.
2002: Palmer Sonya L; Thakur Ganesh A; Makriyannis Alexandros
Cannabinergic ligands.
Chemistry and physics of lipids 2002;121(1-2):3-19.
2002: Picone R P; Fournier D J; Makriyannis A
Ligand based structural studies of the CB1 cannabinoid receptor.
The journal of peptide research : official journal of the American Peptide Society 2002;60(6):348-56.
2002: Papahatjis Demetris P; Nikas Spyros P; Andreou Thanos; Makriyannis Alexandros
Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols.
Bioorganic & medicinal chemistry letters 2002;12(24):3583-6.
2002: Schuel Herbert; Burkman Lani J; Lippes Jack; Crickard Kent; Mahony Mary C; Giuffrida Andrea; Picone Robert P; Makriyannis Alexandros
Evidence that anandamide-signaling regulates human sperm functions required for fertilization.
Molecular reproduction and development 2002;63(3):376-87.
2002: Goutopoulos Andreas; Makriyannis Alexandros
From cannabis to cannabinergics: new therapeutic opportunities.
Pharmacology & therapeutics 2002;95(2):103-17.
2002: Gardner Brian; Zu Li X; Sharma Sherven; Liu Qian; Makriyannis Alexandros; Tashkin Donald P; Dubinett Steven M
Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-beta.
Biochemical and biophysical research communications 2002;290(1):91-6.
2001: Lin S; Duclos R I; Makriyannis A
Preparation of optically pure 4-(hydroxymethyl)-2-pentadecyl-1,3-dioxolanes and their corresponding phosphodiester ether lipid derivatives.
Chemistry and physics of lipids 2001;113(1-2):111-22.
2001: Malan T P; Ibrahim M M; Deng H; Liu Q; Mata H P; Vanderah T; Porreca F; Makriyannis A
CB2 cannabinoid receptor-mediated peripheral antinociception.
Pain 2001;93(3):239-45.
2001: Järbe T U; Lamb R J; Lin S; Makriyannis A
(R)-methanandamide and Delta 9-THC as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide.
Psychopharmacology 2001;156(4):369-80.
2001: Goutopoulos A; Fan P; Khanolkar A D; Xie X Q; Lin S; Makriyannis A
Stereochemical selectivity of methanandamides for the CB1 and CB2 cannabinoid receptors and their metabolic stability.
Bioorganic & medicinal chemistry 2001;9(7):1673-84.
2001: Simoneau I I; Hamza M S; Mata H P; Siegel E M; Vanderah T W; Porreca F; Makriyannis A; Malan T P
The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets.
Anesthesiology 2001;94(5):882-7.
2001: Mavromoustakos T; Calogeropoulou T; Koufaki M; Kolocouris A; Daliani I; Demetzos C; Meng Z; Makriyannis A; Balzarini J; De Clercq E
Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers.
Journal of medicinal chemistry 2001;44(11):1702-9.
2000: Cosenza M; Gifford A N; Gatley S J; Pyatt B; Liu Q; Makriyannis A; Volkow N D
Locomotor activity and occupancy of brain cannabinoid CB1 receptors by the antagonist/inverse agonist AM281.
Synapse (New York, N.Y.) 2000;38(4):477-82.
2000: Khanolkar A D; Palmer S L; Makriyannis A
Molecular probes for the cannabinoid receptors.
Chemistry and physics of lipids 2000;108(1-2):37-52.
2000: Harrington P E; Stergiades I A; Erickson J; Makriyannis A; Tius M A
Synthesis of functionalized cannabinoids.
The Journal of organic chemistry 2000;65(20):6576-82.
2000: Palmer S L; Khanolkar A D; Makriyannis A
Natural and synthetic endocannabinoids and their structure-activity relationships.
Current pharmaceutical design 2000;6(13):1381-97.
2000: Lamb R J; Järbe T U; Makriyannis A; Lin S; Goutopoulos A
Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing.
European journal of pharmacology 2000;398(2):251-8.
2000: Järbe T U; Lamb R J; Lin S; Makriyannis A
Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats: a systematic replication.
Behavioural pharmacology 2000;11(1):81-6.
1999: Gifford A N; Bruneus M; Lin S; Goutopoulos A; Makriyannis A; Volkow N D; Gatley S J
Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374).
European journal of pharmacology 1999;383(1):9-14.
1999: Xie X Q; Han X W; Chen J Z; Eissenstat M; Makriyannis A
High-resolution NMR and computer modeling studies of the cannabimimetic aminoalkylindole prototype WIN-55212-2.
Journal of medicinal chemistry 1999;42(20):4021-7.
1999: Khanolkar A D; Lu D; Fan P; Tian X; Makriyannis A
Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.
Bioorganic & medicinal chemistry letters 1999;9(15):2119-24.
1999: Romero J; Berrendero F; García-Gil L; Lin S Y; Makriyannis A; Ramos J A; Fernández-Ruiz J J
Cannabinoid receptor and WIN-55,212-2-stimulated [35S]GTPgammaS binding and cannabinoid receptor mRNA levels in several brain structures of adult male rats chronically exposed to R-methanandamide.
Neurochemistry international 1999;34(6):473-82.
1999: Piomelli D; Beltramo M; Glasnapp S; Lin S Y; Goutopoulos A; Xie X Q; Makriyannis A
Structural determinants for recognition and translocation by the anandamide transporter.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5802-7.
1999: Lang W; Qin C; Lin S; Khanolkar A D; Goutopoulos A; Fan P; Abouzid K; Meng Z; Biegel D; Makriyannis A
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.
Journal of medicinal chemistry 1999;42(5):896-902.
1999: Lan R; Liu Q; Fan P; Lin S; Fernando S R; McCallion D; Pertwee R; Makriyannis A
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.
Journal of medicinal chemistry 1999;42(4):769-76.
1999: Gifford A N; Bruneus M; Gatley S J; Lan R; Makriyannis A; Volkow N D
Large receptor reserve for cannabinoid actions in the central nervous system.
The Journal of pharmacology and experimental therapeutics 1999;288(2):478-83.
1999: Lan R; Gatley J; Lu Q; Fan P; Fernando S R; Volkow N D; Pertwee R; Makriyannis A
Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a potential human SPECT ligand.
AAPS pharmSci 1999;1(2):E4.
1999: Khanolkar A D; Makriyannis A
Structure-activity relationships of anandamide, an endogenous cannabinoid ligand.
Life sciences 1999;65(6-7):607-16.
1999: González S; Romero J; de Miguel R; Lastres-Becker I; Villanua M A; Makriyannis A; Ramos J A; Fernández-Ruiz J J
Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide.
Life sciences 1999;65(3):327-36.
1998: Järbe T U; Lamb R J; Makriyannis A; Lin S; Goutopoulos A
Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats.
Psychopharmacology 1998;140(4):519-22.
1998: Lin S; Khanolkar A D; Fan P; Goutopoulos A; Qin C; Papahadjis D; Makriyannis A
Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability.
Journal of medicinal chemistry 1998;41(27):5353-61.
1998: de Miguel R; Romero J; Muñoz R M; García-Gil L; González S; Villanua M A; Makriyannis A; Ramos J A; Fernández-Ruiz J J
Effects of cannabinoids on prolactin and gonadotrophin secretion: involvement of changes in hypothalamic gamma-aminobutyric acid (GABA) inputs.
Biochemical pharmacology 1998;56(10):1331-8.
1998: Drake D J; Jensen R S; Busch-Petersen J; Kawakami J K; Concepcion Fernandez-Garcia M; Fan P; Makriyannis A; Tius M A
Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues.
Journal of medicinal chemistry 1998;41(19):3596-608.
1998: Qin C; Lin S; Lang W; Goutopoulos A; Pavlopoulos S; Mauri F; Makriyannis A
Determination of anandamide amidase activity using ultraviolet-active amine derivatives and reverse-phase high-performance liquid chromatography.
Analytical biochemistry 1998;261(1):8-15.
1998: Carriero D; Aberman J; Lin S Y; Hill A; Makriyannis A; Salamone J D
A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing.
Psychopharmacology 1998;137(2):147-56.
1998: Järbe T U; Sheppard R; Lamb R J; Makriyannis A; Lin S; Goutopoulos A
Effects of delta-9-tetrahydrocannabinol and (R)-methanandamide on open-field behavior in rats.
Behavioural pharmacology 1998;9(2):169-74.
1998: Papahatjis D P; Kourouli T; Abadji V; Goutopoulos A; Makriyannis A
Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols.
Journal of medicinal chemistry 1998;41(7):1195-200.
1998: Xie X Q; Pavlopoulos S; DiMeglio C M; Makriyannis A
Conformational studies on a diastereoisomeric pair of tricyclic nonclassical cannabinoids by NMR spectroscopy and computer molecular modeling.
Journal of medicinal chemistry 1998;41(2):167-74.
1998: Gatley S J; Lan R; Volkow N D; Pappas N; King P; Wong C T; Gifford A N; Pyatt B; Dewey S L; Makriyannis A
Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo.
Journal of neurochemistry 1998;70(1):417-23.
1998: Landsman R S; Makriyannis A; Deng H; Consroe P; Roeske W R; Yamamura H I
AM630 is an inverse agonist at the human cannabinoid CB1 receptor.
Life sciences 1998;62(9):PL109-13.
1997: Calignano A; La Rana G; Makriyannis A; Lin S Y; Beltramo M; Piomelli D
Inhibition of intestinal motility by anandamide, an endogenous cannabinoid.
European journal of pharmacology 1997;340(2-3):R7-8.
1997: Gifford A N; Tang Y; Gatley S J; Volkow N D; Lan R; Makriyannis A
Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices.
Neuroscience letters 1997;238(1-2):84-6.
1997: Calignano A; La Rana G; Beltramo M; Makriyannis A; Piomelli D
Potentiation of anandamide hypotension by the transport inhibitor, AM404.
European journal of pharmacology 1997;337(1):R1-2.
1997: Beltramo M; Stella N; Calignano A; Lin S Y; Makriyannis A; Piomelli D
Functional role of high-affinity anandamide transport, as revealed by selective inhibition.
Science (New York, N.Y.) 1997;277(5329):1094-7.
1997: Fernández-Ruiz J J; Muñoz R M; Romero J; Villanua M A; Makriyannis A; Ramos J A
Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics.
Biochemical pharmacology 1997;53(12):1919-27.
1997: Lin S; Duclos R I; Makriyannis A
Syntheses of 1,2-di-O-palmitoyl-sn-glycero-3-phosphocholine (DPPC) and analogs with 13C- and 2H-labeled choline head groups.
Chemistry and physics of lipids 1997;86(2):171-81.
1997: Hosohata Y; Quock R M; Hosohata K; Makriyannis A; Consroe P; Roeske W R; Yamamura H I
AM630 antagonism of cannabinoid-stimulated [35S]GTP gamma S binding in the mouse brain.
European journal of pharmacology 1997;321(1):R1-3.
1997: Gatley S J; Lan R; Pyatt B; Gifford A N; Volkow N D; Makriyannis A
Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors.
Life sciences 1997;61(14):PL 191-7.
1997: Hosohata K; Quock R M; Hosohata Y; Burkey T H; Makriyannis A; Consroe P; Roeske W R; Yamamura H I
AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain.
Life sciences 1997;61(9):PL115-8.
1997: Xie X Q; Moring J; Makriyannis A
Differential scanning calorimetry and small angle x-ray diffraction study of the interaction of (R)-PAF, (R)-ET-18-OME and (R)-Lyso-PAF with model membranes.
Life sciences 1997;61(9):909-23.
1996: Mavromoustakos T; Theodoropoulou E; Yang D P; Lin S Y; Koufaki M; Makriyannis A
The conformational properties of the antineoplastic ether lipid 1-thiohexadecyl-2-O-methyl-S-glycero-3-phosphocholine.
Chemistry and physics of lipids 1996;84(1):21-34.
1996: Khanolkar A D; Abadji V; Lin S; Hill W A; Taha G; Abouzid K; Meng Z; Fan P; Makriyannis A
Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.
Journal of medicinal chemistry 1996;39(22):4515-9.
1996: Busch-Petersen J; Hill W A; Fan P; Khanolkar A; Xie X Q; Tius M A; Makriyannis A
Unsaturated side chain beta-11-hydroxyhexahydrocannabinol analogs.
Journal of medicinal chemistry 1996;39(19):3790-6.
1996: Tsotinis A; Calogeropoulou T; Koufaki M; Souli C; Balzarini J; De Clercq E; Makriyannis A
Synthesis and antiretroviral evaluation of new alkoxy and aryloxy phosphate derivatives of 3'-azido-3'-deoxythymidine.
Journal of medicinal chemistry 1996;39(17):3418-22.
1996: Xie X; Lin S; Moring J; Makriyannis A
Interdigitation of bilayers from ether lipid analogs: (R)-PAF, (R)-Lyso-PAF and the antineoplastic (R)-ET-18-OMe.
Biochimica et biophysica acta 1996;1283(1):111-8.
1996: Gatley S J; Gifford A N; Volkow N D; Lan R; Makriyannis A
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors.
European journal of pharmacology 1996;307(3):331-8.
1996: Koufaki M; Polychroniou V; Calogeropoulou T; Tsotinis A; Drees M; Fiebig H H; LeClerc S; Hendriks H R; Makriyannis A
Alkyl and alkoxyethyl antineoplastic phospholipids.
Journal of medicinal chemistry 1996;39(13):2609-14.
1996: Mavromoustakos T; Theodoropoulou E; Papahatjis D; Kourouli T; Yang D P; Trumbore M; Makriyannis A
Studies on the thermotropic effects of cannabinoids on phosphatidylcholine bilayers using differential scanning calorimetry and small angle X-ray diffraction.
Biochimica et biophysica acta 1996;1281(2):235-44.
1996: Lang W; Qin C; Hill W A; Lin S; Khanolkar A D; Makriyannis A
High-performance liquid chromatographic determination of anandamide amidase activity in rat brain microsomes.
Analytical biochemistry 1996;238(1):40-5.
1996: Xie X Q; Melvin L S; Makriyannis A
The conformational properties of the highly selective cannabinoid receptor ligand CP-55,940.
The Journal of biological chemistry 1996;271(18):10640-7.
1996: Mavromoustakos T; Yang D P; Makriyannis A
Topography and thermotropic properties of cannabinoids in brain sphingomyelin bilayers.
Life sciences 1996;59(23):1969-79.
1996: Romero J; García-Palomero E; Lin S Y; Ramos J A; Makriyannis A; Fernández-Ruiz J J
Extrapyramidal effects of methanandamide, an analog of anandamide, the endogenous CB1 receptor ligand.
Life sciences 1996;58(15):1249-57.
1995: Mavromoustakos T; Yang D P; Makriyannis A
Effects of the anesthetic steroid alphaxalone and its inactive delta 16-analog on the thermotropic properties of membrane bilayers. A model for membrane perturbation.
Biochimica et biophysica acta 1995;1239(2):257-64.
1995: Mavromoustakos T; Yang D P; Makriyannis A
Small angle X-ray diffraction and differential scanning calorimetric studies on O-methyl-(-)-delta 8-tetrahydrocannabinol and its 5' iodinated derivative in membrane bilayers.
Biochimica et biophysica acta 1995;1237(2):183-8.
1995: Pertwee R G; Fernando S R; Griffin G; Abadji V; Makriyannis A
Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations.
European journal of pharmacology 1995;272(1):73-8.
1995: Tius M A; Hill W A; Zou X L; Busch-Petersen J; Kawakami J K; Fernandez-Garcia M C; Drake D J; Abadji V; Makriyannis A
Classical/non-classical cannabinoid hybrids; stereochemical requirements for the southern hydroxyalkyl chain.
Life sciences 1995;56(23-24):2007-12.
1995: Xie X Q; Eissenstat M; Makriyannis A
Common cannabimimetic pharmacophoric requirements between aminoalkyl indoles and classical cannabinoids.
Life sciences 1995;56(23-24):1963-70.
1995: Morse K L; Fournier D J; Li X; Grzybowska J; Makriyannis A
A novel electrophilic high affinity irreversible probe for the cannabinoid receptor.
Life sciences 1995;56(23-24):1957-62.
1995: Pertwee R; Griffin G; Fernando S; Li X; Hill A; Makriyannis A
AM630, a competitive cannabinoid receptor antagonist.
Life sciences 1995;56(23-24):1949-55.
1994: Duclos R I; Chia H H; Abdelmageed O H; Esber H; Fournier D J; Makriyannis A
Syntheses of racemic and nearly optically pure ether lipids and evaluation of in vitro antineoplastic activities.
Journal of medicinal chemistry 1994;37(24):4147-54.
1994: Guo Y; Abadji V; Morse K L; Fournier D J; Li X; Makriyannis A
(-)-11-Hydroxy-7'-isothiocyanato-1',1'-dimethylheptyl-delta 8-THC: a novel, high-affinity irreversible probe for the cannabinoid receptor in the brain.
Journal of medicinal chemistry 1994;37(23):3867-70.
1994: Mavromoustakos T; Yang D P; Makriyannis A
Topography of alphaxalone and delta 16-alphaxalone in membrane bilayers containing cholesterol.
Biochimica et biophysica acta 1994;1194(1):69-74.
1994: Yan G; Yin D; Khanolkar A D; Compton D R; Martin B R; Makriyannis A
Synthesis and pharmacological properties of 11-hydroxy-3-(1',1'-dimethylheptyl)hexahydrocannabinol: a high-affinity cannabinoid agonist.
Journal of medicinal chemistry 1994;37(16):2619-22.
1994: Yin D; Khanolkar A D; Makriyannis A; Froimowitz M
Chiral resolution of 1,3-dimethyl-4-phenylpiperidine derivatives using high-performance liquid chromatography with a chiral stationary phase.
Journal of chromatography. A 1994;678(1):176-9.
1994: Abadji V; Lin S; Taha G; Griffin G; Stevenson L A; Pertwee R G; Makriyannis A
(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.
Journal of medicinal chemistry 1994;37(12):1889-93.
1994: Xie X Q; Yang D P; Melvin L S; Makriyannis A
Conformational analysis of the prototype nonclassical cannabinoid CP-47,497, using 2D NMR and computer molecular modeling.
Journal of medicinal chemistry 1994;37(10):1418-26.
1993: Martin B R; Compton D R; Semus S F; Lin S; Marciniak G; Grzybowska J; Charalambous A; Makriyannis A
Pharmacological evaluation of iodo and nitro analogs of delta 8-THC and delta 9-THC.
Pharmacology, biochemistry, and behavior 1993;46(2):295-301.
1993: DiMeglio C M; Froimowitz M; Makriyannis A
Conformational analysis of the opioid phenylmorphan and its 9 alpha-methyl analogue in solution using high-resolution nuclear magnetic resonance spectroscopy.
Pharmaceutical research 1993;10(8):1200-5.
1993: Makriyannis A; DiMeglio C M; DeJong A P; el-Khateeb S
Hallucinogenic receptor models: interaction of imidazolium chloride with amphetamine analogs.
Molecular pharmacology 1993;43(1):78-83.
1993: Yang D P; Mavromoustakos T; Makriyannis A
Small angle X-ray diffraction studies of (-)-delta 8-tetrahydrocannabinol and its O-methyl analog in membranes.
Life sciences 1993;53(7):PL117-22.
1993: Makriyannis A
Probes for the cannabinoid sites of action.
NIDA research monograph 1993;134():253-67.
1992: Froimowitz M; DiMeglio C M; Makriyannis A
Conformational preferences of the kappa-selective opioid agonist U50488. A combined molecular mechanics and nuclear magnetic resonance study.
Journal of medicinal chemistry 1992;35(17):3085-94.
1992: Charalambous A; Yan G; Houston D B; Howlett A C; Compton D R; Martin B R; Makriyannis A
5'-Azido-delta 8-THC: a novel photoaffinity label for the cannabinoid receptor.
Journal of medicinal chemistry 1992;35(16):3076-9.
1992: Yang D P; Mavromoustakos T; Beshah K; Makriyannis A
Amphipathic interactions of cannabinoids with membranes. A comparison between delta 8-THC and its O-methyl analog using differential scanning calorimetry, X-ray diffraction and solid state 2H-NMR.
Biochimica et biophysica acta 1992;1103(1):25-36.
1991: Yang D P; Banijamali A; Charalambous A; Marciniak G; Makriyannis A
Solid state 2H-NMR as a method for determining the orientation of cannabinoid analogs in membranes.
Pharmacology, biochemistry, and behavior 1991;40(3):553-7.
1991: Mavromoustakos T; Yang D P; Broderick W; Fournier D; Makriyannis A
Small angle x-ray diffraction studies on the topography of cannabinoids in synaptic plasma membranes.
Pharmacology, biochemistry, and behavior 1991;40(3):547-52.
1991: Charalambous A; Lin S; Marciniak G; Banijamali A; Friend F L; Compton D R; Martin B R; Makriyannis A
Pharmacological evaluation of halogenated delta 8-THC analogs.
Pharmacology, biochemistry, and behavior 1991;40(3):509-12.
1991: Charalambous A; Marciniak G; Shiue C Y; Dewey S L; Schlyer D J; Wolf A P; Makriyannis A
PET studies in the primate brain and biodistribution in mice using (-)-5'-18F-delta 8-THC.
Pharmacology, biochemistry, and behavior 1991;40(3):503-7.
1991: Makriyannis A; DiMeglio C M; Fesik S W
Anesthetic steroid mobility in model membrane preparations as examined by high-resolution 1H and 2H NMR spectroscopy.
Journal of medicinal chemistry 1991;34(5):1700-3.
1991: Burstein S H; Audette C A; Charalambous A; Doyle S A; Guo Y; Hunter S A; Makriyannis A
Detection of cannabinoid receptors by photoaffinity labelling.
Biochemical and biophysical research communications 1991;176(1):492-7.
1991: Makriyannis A; Yang D P; Mavromoustakos T
Combined use of solid-state nuclear magnetic resonance spectroscopy, small-angle x-ray diffraction, and differential scanning calorimetry in studies of cannabinoid: membrane interactions.
NIDA research monograph 1991;112():106-28.
1990: Melchior D L; Carruthers A; Makriyannis A; Duclos R I; Abdel-Mageed O H
Alterations in red blood cell sugar transport by nanomolar concentrations of alkyl lysophospholipid.
Biochimica et biophysica acta 1990;1028(1):1-8.
1990: Makriyannis A; Yang D P; Griffin R G; Das Gupta S K
The perturbation of model membranes by (-)-delta 9-tetrahydrocannabinol. Studies using solid-state 2H- and 13C-NMR.
Biochimica et biophysica acta 1990;1028(1):31-42.
1990: Mavromoustakos T; Yang D P; Charalambous A; Herbette L G; Makriyannis A
Study of the topography of cannabinoids in model membranes using X-ray diffraction.
Biochimica et biophysica acta 1990;1024(2):336-44.
1990: Abdelmageed O H; Duclos R I; Abushanab E; Makriyannis A
Chirospecific syntheses of 2H- and 13C-labeled 1-O-alkyl-2-O-alkyl'-sn-glycero-3-phosphoethanolamines and 1-O-alkyl-2-O-alkyl'-sn-glycero-3-phosphocholines.
Chemistry and physics of lipids 1990;54(1):49-59.
1990: Makriyannis A; Yang D P; Mavromoustakos T
The molecular features of membrane perturbation by anaesthetic steroids: a study using differential scanning calorimetry, small angle X-ray diffraction and solid state 2H NMR.
Ciba Foundation symposium 1990;153():172-84; discussion 185-9.
1990: Makriyannis A; Rapaka R S
The molecular basis of cannabinoid activity.
Life sciences 1990;47(24):2173-84.
1989: Makriyannis A; Banijamali A; Jarrell H C; Yang D P
The orientation of (-)-delta 9-tetrahydrocannabinol in DPPC bilayers as determined from solid-state 2H-NMR.
Biochimica et biophysica acta 1989;986(1):141-5.
1989: Kriwacki R W; Makriyannis A
The conformational analysis of delta 9- and delta 9,11-tetrahydrocannabinols in solution using high resolution nuclear magnetic resonance spectroscopy.
Molecular pharmacology 1989;35(4):495-503.
1988: Van der Schyf C J; Mavromoustakos T; Makriyannis A
The conformation of (-) 8 alpha and (-) 8 beta-hydroxy-delta 9-tetrahydrocannabinols and their interactions with model membranes.
Life sciences 1988;42(22):2231-9.
1987: Makriyannis A; Rapaka R S
The medicinal chemistry of cannabinoids: an overview.
NIDA research monograph 1987;79():204-10.
1987: Makriyannis A; Banijamali A; Van der Schyf C; Jarrell H
Interactions of cannabinoids with membranes. The role of cannabinoid stereochemistry and absolute configuration and the orientation of delta-9-THC in the membrane bilayer.
NIDA research monograph 1987;79():123-33.

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