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Alexandros Makriyannis
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18
Thakur, Ganesh
17
Järbe, Torbjörn
16
Mavromoustakos, Thomas
15
Khanolkar, Atmaram
15
Fan, Pusheng
13
Lin, Sonyuan
11
Janero, David
11
Salamone, John
11
Gatley, John
10
Xie, Xiang-Qun
9
Volkow, Nora
9
Gifford, Andrew
9
Nikas, Spyros
8
Piomelli, Daniele
8
Lamb, Richard
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All Publications
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2009: Storr Martin A; Keenan Catherine M; Zhang Hong; Patel Kamala D; Makriyannis Alexandros; Sharkey Keith A
Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis.
Inflammatory bowel diseases 2009;15(11):1678-85.
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2009: Sink K S; Segovia K N; Nunes E J; Collins L E; Vemuri V K; Thakur G; Makriyannis A; Salamone J D
Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats.
Psychopharmacology 2009;206(2):223-32.
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2009: Tiburu Elvis K; Gulla Stefano V; Tiburu Mark; Janero David R; Budil David E; Makriyannis Alexandros
Dynamic conformational responses of a human cannabinoid receptor-1 helix domain to its membrane environment.
Biochemistry 2009;48(22):4895-904.
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2009: Tiburu Elvis K; Tyukhtenko Sergiy; Deshmukh Lalit; Vinogradova Olga; Janero David R; Makriyannis Alexandros
Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments.
Biochemical and biophysical research communications 2009;384(2):243-8.
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2009: Tiburu Elvis K; Bowman Anna L; Struppe Jochem O; Janero David R; Avraham Hava K; Makriyannis Alexandros
Solid-state NMR and molecular dynamics characterization of cannabinoid receptor-1 (CB1) helix 7 conformational plasticity in model membranes.
Biochimica et biophysica acta 2009;1788(5):1159-67.
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2009: Janero David R; Vadivel Subramanian K; Makriyannis Alexandros
Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: drug-discovery strategies.
International review of psychiatry (Abingdon, England) 2009;21(2):122-33.
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2009: Järbe Torbjörn U C; Li Chen; Liu Qian; Makriyannis Alexandros
Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog.
Psychopharmacology 2009;203(2):229-39.
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2009: Janero David R; Makriyannis Alexandros
Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis.
Expert opinion on emerging drugs 2009;14(1):43-65.
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2009: Kunos George; Osei-Hyiaman Douglas; Bátkai Sándor; Sharkey Keith A; Makriyannis Alexandros
Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?
Trends in pharmacological sciences 2009;30(1):1-7.
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2008: Pei Ying; Mercier Richard W; Anday Jenine K; Thakur Ganesh A; Zvonok Alexander M; Hurst Dow; Reggio Patricia H; Janero David R; Makriyannis Alexandros
Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation.
Chemistry & biology 2008;15(11):1207-19.
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2008: Lu Tzong-Shi; Avraham Hava Karsenty; Seng Seyha; Tachado Souvenir D; Koziel Henry; Makriyannis Alexandros; Avraham Shalom
Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6406-16.
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2008: Guo Jianxin; Yang De-Ping; Chari Ravi; Tian Xiaoyu; Pavlopoulos Spiro; Lu Dai; Makriyannis Alexandros
Magnetically aligned bicelles to study the orientation of lipophilic ligands in membrane bilayers.
Journal of medicinal chemistry 2008;51(21):6793-9.
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2008: Yao Fenmei; Li Chen; Vadivel Subramanian K; Bowman Anna L; Makriyannis Alexandros
Development of novel tail-modified anandamide analogs.
Bioorganic & medicinal chemistry letters 2008;18(22):5912-5.
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2008: Rahn Elizabeth J; Zvonok Alexander M; Thakur Ganesh A; Khanolkar Atmaram D; Makriyannis Alexandros; Hohmann Andrea G
Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats.
The Journal of pharmacology and experimental therapeutics 2008;327(2):584-91.
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2008: Järbe T U C; LeMay B J; Olszewska T; Vemuri V K; Wood J T; Makriyannis A
Intrinsic effects of AM4113, a putative neutral CB1 receptor selective antagonist, on open-field behaviors in rats.
Pharmacology, biochemistry, and behavior 2008;91(1):84-90.
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2008: Hodge Janel; Bow Joshua P; Plyler Kimberly S; Vemuri V Kiran; Wisniecki Ania; Salamone John D; Makriyannis Alexandros; McLaughlin Peter J
The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats.
Behavioural brain research 2008;193(2):298-305.
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2008: Lu Dai; Guo Jianxin; Duclos Richard I; Bowman Anna L; Makriyannis Alexandros
Bornyl- and isobornyl-Delta8-tetrahydrocannabinols: a novel class of cannabinergic ligands.
Journal of medicinal chemistry 2008;51(20):6393-9.
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2008: Magrioti Victoria; Naxakis George; Hadjipavlou-Litina Dimitra; Makriyannis Alexandros; Kokotos George
A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity.
Bioorganic & medicinal chemistry letters 2008;18(20):5424-7.
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2008: Zvonok Nikolai; Pandarinathan Lakshmipathi; Williams John; Johnston Meghan; Karageorgos Ioannis; Janero David R; Krishnan Srinivasan C; Makriyannis Alexandros
Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis.
Chemistry & biology 2008;15(8):854-62.
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2008: Järbe Torbjörn U C; Li Chen; Vadivel Subramanian K; Makriyannis Alexandros
Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.
Psychopharmacology 2008;198(4):467-78.
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2008: Zvonok Nikolai; Williams John; Johnston Meghan; Pandarinathan Lakshmipathi; Janero David R; Li Jing; Krishnan Srinivasan C; Makriyannis Alexandros
Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification.
Journal of proteome research 2008;7(5):2158-64.
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2008: Kapur Ankur; Samaniego Patrick; Thakur Ganesh A; Makriyannis Alexandros; Abood Mary E
Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction.
The Journal of pharmacology and experimental therapeutics 2008;325(1):341-8.
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2008: Vemuri V Kiran; Janero David R; Makriyannis Alexandros
Pharmacotherapeutic targeting of the endocannabinoid signaling system: drugs for obesity and the metabolic syndrome.
Physiology & behavior 2008;93(4-5):671-86.
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2008: Sink K S; Vemuri V K; Olszewska T; Makriyannis A; Salamone J D
Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior.
Psychopharmacology 2008;196(4):565-74.
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2008: Sink Kelly S; McLaughlin Peter J; Wood Jodi Anne T; Brown Cara; Fan Pusheng; Vemuri V Kiran; Peng Yan; Olszewska Teresa; Thakur Ganesh A; Makriyannis Alex; Parker Linda A; Salamone John D
The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(4):946-55.
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2008: Scherma Maria; Medalie Julie; Fratta Walter; Vadivel Subramanian K; Makriyannis Alexandros; Piomelli Daniele; Mikics Eva; Haller Jozsef; Yasar Sevil; Tanda Gianluigi; Goldberg Steven R
The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition.
Neuropharmacology 2008;54(1):129-40.
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2008: Wood JodiAnne T; Williams John S; Pandarinathan Lakshmipathi; Courville Amber; Keplinger Melissa R; Janero David R; Vouros Paul; Makriyannis Alexandros; Lammi-Keefe Carol J
Comprehensive profiling of the human circulating endocannabinoid metabolome: clinical sampling and sample storage parameters.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(9):1289-95.
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2007: Khanolkar Atmaram D; Lu Dai; Ibrahim Mohab; Duclos Richard I; Thakur Ganesh A; Malan T Phillip; Porreca Frank; Veerappan Vijayabaskar; Tian Xiaoyu; George Clifford; Parrish Damon A; Papahatjis Demetris P; Makriyannis Alexandros
Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity.
Journal of medicinal chemistry 2007;50(26):6493-500.
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2007: Chambers Adam P; Vemuri V Kiran; Peng Yan; Wood Jodianne T; Olszewska Teresa; Pittman Quentin J; Makriyannis Alexandros; Sharkey Keith A
A neutral CB1 receptor antagonist reduces weight gain in rat.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(6):R2185-93.
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2007: Järbe Torbjörn U C; DiPatrizio Nicholas V; Li Chen; Makriyannis Alexandros
Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats.
Behavioural pharmacology 2007;18(7):673-80.
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2007: Vadivel Subramanian K; Vardarajan Sundararaman; Duclos Richard I; Wood JodiAnne T; Guo Jianxin; Makriyannis Alexandros
Conformationally constrained analogues of 2-arachidonoylglycerol.
Bioorganic & medicinal chemistry letters 2007;17(21):5959-63.
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2007: Rahn E J; Makriyannis A; Hohmann A G
Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.
British journal of pharmacology 2007;152(5):765-77.
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2007: Janero David R; Makriyannis Alexandros
Targeted modulators of the endogenous cannabinoid system: future medications to treat addiction disorders and obesity.
Current psychiatry reports 2007;9(5):365-73.
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2007: Karanian David A; Karim Sanjida L; Wood JodiAnne T; Williams John S; Lin Sonyuan; Makriyannis Alexandros; Bahr Ben A
Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage.
The Journal of pharmacology and experimental therapeutics 2007;322(3):1059-66.
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2007: Papahatjis Demetris P; Nahmias Victoria R; Nikas Spyros P; Andreou Thanos; Alapafuja Shakiru O; Tsotinis Andrew; Guo Jianxin; Fan Pusheng; Makriyannis Alexandros
C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols.
Journal of medicinal chemistry 2007;50(17):4048-60.
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2007: Williams John; Wood JodiAnne; Pandarinathan Lakshmipathi; Karanian David A; Bahr Ben A; Vouros Paul; Makriyannis Alexandros
Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS.
Analytical chemistry 2007;79(15):5582-93.
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2007: Salamone John D; McLaughlin Peter J; Sink Kelly; Makriyannis Alexandros; Parker Linda A
Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions.
Physiology & behavior 2007;91(4):383-8.
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2007: Zvonok Nikolai; Yaddanapudi Suma; Williams John; Dai Shujia; Dong Keling; Rejtar Tomas; Karger Barry L; Makriyannis Alexandros
Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor.
Journal of proteome research 2007;6(6):2068-79.
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2007: Kapur Ankur; Hurst Dow P; Fleischer Daniel; Whitnell Rob; Thakur Ganesh A; Makriyannis Alexandros; Reggio Patricia H; Abood Mary E
Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.
Molecular pharmacology 2007;71(6):1512-24.
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2007: Solinas Marcello; Tanda Gianluigi; Justinova Zuzana; Wertheim Carrie E; Yasar Sevil; Piomelli Daniele; Vadivel Subramanian K; Makriyannis Alexandros; Goldberg Steven R
The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport.
The Journal of pharmacology and experimental therapeutics 2007;321(1):370-80.
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2007: Gutierrez T; Farthing J N; Zvonok A M; Makriyannis A; Hohmann A G
Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis.
British journal of pharmacology 2007;150(2):153-63.
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2007: Jiang Shuxian; Fu Yigong; Williams John; Wood Jodianne; Pandarinathan Lakshmipathi; Avraham Shiri; Makriyannis Alexandros; Avraham Shalom; Avraham Hava Karsenty
Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.
PloS one 2007;2(7):e641.
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2006: Järbe Torbjörn U C; Lamb Richard J; Liu Qian; Makriyannis Alexandros
Discriminative stimulus functions of AM-1346, a CB1R selective anandamide analog in rats trained with Delta9-THC or (R)-methanandamide (AM-356).
Psychopharmacology 2006;188(3):315-23.
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2006: Koufaki Maria; Kiziridi Christina; Papazafiri Panagiota; Vassilopoulos Athanasios; Varró Andràs; Nagy Zsolt; Farkas Attila; Makriyannis Alexandros
Synthesis and biological evaluation of benzopyran analogues bearing class III antiarrhythmic pharmacophores.
Bioorganic & medicinal chemistry 2006;14(19):6666-78.
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2006: Järbe T U C; Ross T; DiPatrizio N V; Pandarinathan L; Makriyannis A
Effects of the CB1R agonist WIN-55,212-2 and the CB1R antagonists SR-141716 and AM-1387: open-field examination in rats.
Pharmacology, biochemistry, and behavior 2006;85(1):243-52.
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2006: Kim Kathline; Moore Dan H; Makriyannis Alexandros; Abood Mary E
AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis.
European journal of pharmacology 2006;542(1-3):100-5.
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2006: Dhawan Jasbeer; Deng Hongfeng; Gatley S John; Makriyannis Alexandros; Akinfeleye Tolulope; Bruneus Magalie; Dimaio Alexis A; Gifford Andrew N
Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[125/131I]AM2233.
Synapse (New York, N.Y.) 2006;60(2):93-101.
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2006: Ibrahim Mohab M; Rude Megan L; Stagg Nicola J; Mata Heriberto P; Lai Josephine; Vanderah Todd W; Porreca Frank; Buckley Nancy E; Makriyannis Alexandros; Malan T Philip
CB2 cannabinoid receptor mediation of antinociception.
Pain 2006;122(1-2):36-42.
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2006: Bahr Ben A; Karanian David A; Makanji Sagar S; Makriyannis Alexandros
Targeting the endocannabinoid system in treating brain disorders.
Expert opinion on investigational drugs 2006;15(4):351-65.
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2006: McLaughlin Peter J; Qian Liu; Wood JodiAnne T; Wisniecki Ania; Winston Keisha M; Swezey Lynn A; Ishiwari Keita; Betz Adrienne J; Pandarinathan Lakshmipathi; Xu Wei; Makriyannis Alexandros; Salamone John D
Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/inverse agonist AM 1387.
Pharmacology, biochemistry, and behavior 2006;83(3):396-402.
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2006: Papahatjis Demetris P; Nahmias Victoria R; Andreou Thanos; Fan Pusheng; Makriyannis Alexandros
Structural modifications of the cannabinoid side chain towards C3-aryl and 1',1'-cycloalkyl-1'-cyano cannabinoids.
Bioorganic & medicinal chemistry letters 2006;16(6):1616-20.
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2006: Chen Jian-Zhong; Han Xiu-Wen; Liu Qian; Makriyannis Alexandros; Wang Junmei; Xie Xiang-Qun
3D-QSAR studies of arylpyrazole antagonists of cannabinoid receptor subtypes CB1 and CB2. A combined NMR and CoMFA approach.
Journal of medicinal chemistry 2006;49(2):625-36.
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2006: Järbe Torbjörn U C; Liu Quian; Makriyannis Alexandros
Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats.
Psychopharmacology 2006;184(1):36-45.
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2006: Williams John; Pandarinathan Lakshmipathi; Wood JodiAnne; Vouros Paul; Makriyannis Alexandros
Endocannabinoid metabolomics: a novel liquid chromatography-mass spectrometry reagent for fatty acid analysis.
The AAPS journal 2006;8(4):E655-60.
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2006: Lu Dai; Vemuri V Kiran; Duclos Richard I; Makriyannis Alexandros
The cannabinergic system as a target for anti-inflammatory therapies.
Current topics in medicinal chemistry 2006;6(13):1401-26.
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2006: Pavlopoulos Spiro; Thakur Ganesh A; Nikas Spyros P; Makriyannis Alexandros
Cannabinoid receptors as therapeutic targets.
Current pharmaceutical design 2006;12(14):1751-69.
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2006: Thakur Ganesh A; Nikas Spyros P; Duclos Richard I; Makriyannis Alexandros
Methods for the synthesis of cannabinergic ligands.
Methods in molecular medicine 2006;123():113-48.
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2005: Thakur Ganesh A; Duclos Richard I; Makriyannis Alexandros
Natural cannabinoids: templates for drug discovery.
Life sciences 2005;78(5):454-66.
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2005: Picone Robert P; Khanolkar Atmaram D; Xu Wei; Ayotte Lionel A; Thakur Ganesh A; Hurst Dow P; Abood Mary E; Reggio Patricia H; Fournier Donna J; Makriyannis Alexandros
(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor.
Molecular pharmacology 2005;68(6):1623-35.
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2005: Solinas Marcello; Panlilio Leigh V; Tanda Gianluigi; Makriyannis Alexandros; Matthews Stephanie A; Goldberg Steven R
Cannabinoid agonists but not inhibitors of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(11):2046-57.
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2005: Van Sickle Marja D; Duncan Marnie; Kingsley Philip J; Mouihate Abdeslam; Urbani Paolo; Mackie Ken; Stella Nephi; Makriyannis Alexandros; Piomelli Daniele; Davison Joseph S; Marnett Lawrence J; Di Marzo Vincenzo; Pittman Quentin J; Patel Kamala D; Sharkey Keith A
Identification and functional characterization of brainstem cannabinoid CB2 receptors.
Science (New York, N.Y.) 2005;310(5746):329-32.
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2005: Li Chen; Xu Wei; Vadivel Subramanian K; Fan Pusheng; Makriyannis Alexandros
High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor.
Journal of medicinal chemistry 2005;48(20):6423-9.
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2005: Deng Hongfeng; Gifford Andrew N; Zvonok Alexander M; Cui Guangjian; Li Xiuyan; Fan Pusheng; Deschamps Jeffrey R; Flippen-Anderson Judith L; Gatley S John; Makriyannis Alexandros
Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.
Journal of medicinal chemistry 2005;48(20):6386-92.
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2005: McLaughlin P J; Brown C M; Winston K M; Thakur G; Lu D; Makriyannis A; Salamone J D
The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats.
Behavioural pharmacology 2005;16(5-6):477-86.
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2005: Makriyannis Alexandros; Tian Xiaoyu; Guo Jianxin
How lipophilic cannabinergic ligands reach their receptor sites.
Prostaglandins & other lipid mediators 2005;77(1-4):210-8.
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2005: Xu W; Filppula S A; Mercier R; Yaddanapudi S; Pavlopoulos S; Cai J; Pierce W M; Makriyannis A
Purification and mass spectroscopic analysis of human CB1 cannabinoid receptor functionally expressed using the baculovirus system.
The journal of peptide research : official journal of the American Peptide Society 2005;66(3):138-50.
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2005: Woelkart Karin; Xu Wei; Pei Ying; Makriyannis Alexandros; Picone Robert P; Bauer Rudolf
The endocannabinoid system as a target for alkamides from Echinacea angustifolia roots.
Planta medica 2005;71(8):701-5.
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2005: Karanian David A; Brown Queenie B; Makriyannis Alexandros; Kosten Therese A; Bahr Ben A
Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(34):7813-20.
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2005: Souli Charikleia; Avlonitis Nicolaos; Calogeropoulou Theodora; Tsotinis Andrew; Maksay Gábor; Bíró Tímea; Politi Aggeliki; Mavromoustakos Thomas; Makriyannis Alexandros; Reis Heribert; Papadopoulos Manthos
Novel 17beta-substituted conformationally constrained neurosteroids that modulate GABA A receptors.
Journal of medicinal chemistry 2005;48(16):5203-14.
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2005: Tian Xiaoyu; Guo Jianxin; Yao Fenmei; Yang De-Ping; Makriyannis Alexandros
The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer.
The Journal of biological chemistry 2005;280(33):29788-95.
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2005: Makriyannis Alexandros; Guo Jianxin; Tian Xiaoyu
Albumin enhances the diffusion of lipophilic drugs into the membrane bilayer.
Life sciences 2005;77(14):1605-11.
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2005: Thakur Ganesh A; Nikas Spyros P; Makriyannis Alexandros
CB1 cannabinoid receptor ligands.
Mini reviews in medicinal chemistry 2005;5(7):631-40.
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2005: Lu Dai; Meng Zhaoxing; Thakur Ganesh A; Fan Pusheng; Steed John; Tartal Cindy L; Hurst Dow P; Reggio Patricia H; Deschamps Jeffrey R; Parrish Damon A; George Clifford; Järbe Torbjörn U C; Lamb Richard J; Makriyannis Alexandros
Adamantyl cannabinoids: a novel class of cannabinergic ligands.
Journal of medicinal chemistry 2005;48(14):4576-85.
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2005: McLaughlin P J; Winston K M; Limebeer C L; Parker L A; Makriyannis A; Salamone J D
The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats.
Psychopharmacology 2005;180(2):286-93.
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2005: Makriyannis Alexandros; Mechoulam Raphael; Piomelli Daniele
Therapeutic opportunities through modulation of the endocannabinoid system.
Neuropharmacology 2005;48(8):1068-71.
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2005: McLaughlin Peter J; Lu Dai; Winston Keisha M; Thakur Ganesh; Swezey Lynn A; Makriyannis Alexandros; Salamone John D
Behavioral effects of the novel cannabinoid full agonist AM 411.
Pharmacology, biochemistry, and behavior 2005;81(1):78-88.
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2005: Li Zizhong; Gifford Andrew; Liu Qian; Thotapally Rajesh; Ding Yu-Shin; Makriyannis Alexandros; Gatley S John
Candidate PET radioligands for cannabinoid CB1 receptors: [18F]AM5144 and related pyrazole compounds.
Nuclear medicine and biology 2005;32(4):361-6.
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2005: Ibrahim Mohab M; Porreca Frank; Lai Josephine; Albrecht Phillip J; Rice Frank L; Khodorova Alla; Davar Gudarz; Makriyannis Alexandros; Vanderah Todd W; Mata Heriberto P; Malan T Philip
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3093-8.
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2005: Choi Gregory; Guo Jianxin; Makriyannis Alexandros
The conformation of the cytoplasmic helix 8 of the CB1 cannabinoid receptor using NMR and circular dichroism.
Biochimica et biophysica acta 2005;1668(1):1-9.
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2005: Karanian David A; Brown Queenie B; Makriyannis Alexandros; Bahr Ben A
Blocking cannabinoid activation of FAK and ERK1/2 compromises synaptic integrity in hippocampus.
European journal of pharmacology 2005;508(1-3):47-56.
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2005: Thakur G A; Nikas S P; Li C; Makriyannis A
Structural requirements for cannabinoid receptor probes.
Handbook of experimental pharmacology 2005;(168):209-46.
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2004: Filppula S; Yaddanapudi S; Mercier R; Xu W; Pavlopoulos S; Makriyannis A
Purification and mass spectroscopic analysis of human CB2 cannabinoid receptor expressed in the baculovirus system.
The journal of peptide research : official journal of the American Peptide Society 2004;64(6):225-36.
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2004: Nackley A G; Zvonok A M; Makriyannis A; Hohmann A G
Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation.
Journal of neurophysiology 2004;92(6):3562-74.
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2004: Järbe Torbjörn U C; Harris Michele Y; Li Chen; Liu Qian; Makriyannis Alexandros
Discriminative stimulus effects in rats of SR-141716 (rimonabant), a cannabinoid CB1 receptor antagonist.
Psychopharmacology 2004;177(1-2):35-45.
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2004: Järbe T U C; DiPatrizio N V; Lu D; Makriyannis A
(-)-Adamantyl-delta8-tetrahydrocannabinol (AM-411), a selective cannabinoid CB1 receptor agonist: effects on open-field behaviors and antagonism by SR-141716 in rats.
Behavioural pharmacology 2004;15(7):517-21.
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2004: Czoty Paul W; Ramanathan Chinnasamy R; Mutschler Nicole H; Makriyannis Alexandros; Bergman Jack
Drug discrimination in methamphetamine-trained monkeys: effects of monoamine transporter inhibitors.
The Journal of pharmacology and experimental therapeutics 2004;311(2):720-7.
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2004: Czoty Paul W; Makriyannis Alexandros; Bergman Jack
Methamphetamine discrimination and in vivo microdialysis in squirrel monkeys.
Psychopharmacology 2004;175(2):170-8.
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2004: Luk Terry; Jin Wenzhen; Zvonok Alexander; Lu Dai; Lin Xin-Zhong; Chavkin Charles; Makriyannis Alexandros; Mackie Ken
Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist.
British journal of pharmacology 2004;142(3):495-500.
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2004: Hohmann Andrea G; Farthing Jesse N; Zvonok Alexander M; Makriyannis Alexandros
Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin.
The Journal of pharmacology and experimental therapeutics 2004;308(2):446-53.
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2004: Arizzi M N; Cervone K M; Aberman J E; Betz A; Liu Q; Lin S; Makriyannis A; Salamone J D
Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide.
Life sciences 2004;74(8):1001-11.
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2004: Nikas Spyros P; Grzybowska Jolanta; Papahatjis Demetris P; Charalambous Avgui; Banijamali Ali R; Chari Ravi; Fan Pusheng; Kourouli Therapia; Lin Sonyuan; Nitowski Albert J; Marciniak Gilbert; Guo Yan; Li Xiuyan; Wang Chia-Lin J; Makriyannis Alexandros
The role of halogen substitution in classical cannabinoids: a CB1 pharmacophore model.
The AAPS journal 2004;6(4):e30.
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2003: McLaughlin P J; Winston K; Swezey L; Wisniecki A; Aberman J; Tardif D J; Betz A J; Ishiwari K; Makriyannis A; Salamone J D
The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats.
Behavioural pharmacology 2003;14(8):583-8.
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2003: Koufaki Maria; Calogeropoulou Theodora; Rekka Eleni; Chryselis Michael; Papazafiri Panagiota; Gaitanaki Catherine; Makriyannis Alexandros
Bifunctional agents for reperfusion arrhythmias: novel hybrid vitamin E/class I antiarrhythmics.
Bioorganic & medicinal chemistry 2003;11(23):5209-19.
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2003: Guo Jianxin; Pavlopoulos Spiro; Tian Xiaoyu; Lu Dai; Nikas Spyros P; Yang De-Ping; Makriyannis Alexandros
Conformational study of lipophilic ligands in phospholipid model membrane systems by solution NMR.
Journal of medicinal chemistry 2003;46(23):4838-46.
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2003: Quartilho Aline; Mata Heriberto P; Ibrahim Mohab M; Vanderah Todd W; Porreca Frank; Makriyannis Alexandros; Malan T Philip
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors.
Anesthesiology 2003;99(4):955-60.
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2003: Ibrahim Mohab M; Deng Hongfeng; Zvonok Alexander; Cockayne Debra A; Kwan Joyce; Mata Heriberto P; Vanderah Todd W; Lai Josephine; Porreca Frank; Makriyannis Alexandros; Malan T Philip
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10529-33.
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2003: Järbe Torbjörn U C; DiPatrizio Nicholas V; Li Chen; Makriyannis Alexandros
The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats.
Pharmacology, biochemistry, and behavior 2003;75(4):809-21.
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2003: Papahatjis Demetris P; Nikas Spyros P; Kourouli Therapia; Chari Ravi; Xu Wei; Pertwee Roger G; Makriyannis Alexandros
Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'.
Journal of medicinal chemistry 2003;46(15):3221-9.
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2003: Järbe Torbjörn U C; Lamb Richard J; Liu Qian; Makriyannis Alexandros
(R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A.
European journal of pharmacology 2003;466(1-2):121-7.
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2003: Lastres-Becker Isabel; de Miguel Rosario; De Petrocellis Luciano; Makriyannis Alexandros; Di Marzo Vincenzo; Fernández-Ruiz Javier
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.
Journal of neurochemistry 2003;84(5):1097-109.
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2003: Avlonitis Nikos; Lekka Eleni; Detsi Anastasia; Koufaki Maria; Calogeropoulou Theodora; Scoulica Efi; Siapi Eleni; Kyrikou Ioanna; Mavromoustakos Thomas; Tsotinis Andrew; Grdadolnik Simona Golic; Makriyannis Alexandros
Antileishmanial ring-substituted ether phospholipids.
Journal of medicinal chemistry 2003;46(5):755-67.
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2003: Malan T Philip; Ibrahim Mohab M; Lai Josephine; Vanderah Todd W; Makriyannis Alexandros; Porreca Frank
CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?
Current opinion in pharmacology 2003;3(1):62-7.
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2003: Chu Chester; Ramamurthy Arun; Makriyannis Alexandros; Tius Marcus A
Synthesis of covalent probes for the radiolabeling of the cannabinoid receptor.
The Journal of organic chemistry 2003;68(1):55-61.
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2003: Nackley A G; Makriyannis A; Hohmann A G
Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
Neuroscience 2003;119(3):747-57.
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2002: Thakur Ganesh A; Palmer Sonya L; Harrington Paul E; Stergiades Ioanna A; Tius Marcus A; Makriyannis Alexandros
Enantiomeric resolution of a novel chiral cannabinoid receptor ligand.
Journal of biochemical and biophysical methods 2002;54(1-3):415-22.
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2002: Malan T Philip; Ibrahim Mohab M; Vanderah Todd W; Makriyannis Alexandros; Porreca Frank
Inhibition of pain responses by activation of CB(2) cannabinoid receptors.
Chemistry and physics of lipids 2002;121(1-2):191-200.
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2002: Gifford Andrew N; Makriyannis Alexandros; Volkow Nora D; Gatley S John
In vivo imaging of the brain cannabinoid receptor.
Chemistry and physics of lipids 2002;121(1-2):65-72.
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2002: Palmer Sonya L; Thakur Ganesh A; Makriyannis Alexandros
Cannabinergic ligands.
Chemistry and physics of lipids 2002;121(1-2):3-19.
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2002: Picone R P; Fournier D J; Makriyannis A
Ligand based structural studies of the CB1 cannabinoid receptor.
The journal of peptide research : official journal of the American Peptide Society 2002;60(6):348-56.
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2002: Papahatjis Demetris P; Nikas Spyros P; Andreou Thanos; Makriyannis Alexandros
Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols.
Bioorganic & medicinal chemistry letters 2002;12(24):3583-6.
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2002: Schuel Herbert; Burkman Lani J; Lippes Jack; Crickard Kent; Mahony Mary C; Giuffrida Andrea; Picone Robert P; Makriyannis Alexandros
Evidence that anandamide-signaling regulates human sperm functions required for fertilization.
Molecular reproduction and development 2002;63(3):376-87.
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2002: Goutopoulos Andreas; Makriyannis Alexandros
From cannabis to cannabinergics: new therapeutic opportunities.
Pharmacology & therapeutics 2002;95(2):103-17.
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2002: Gardner Brian; Zu Li X; Sharma Sherven; Liu Qian; Makriyannis Alexandros; Tashkin Donald P; Dubinett Steven M
Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-beta.
Biochemical and biophysical research communications 2002;290(1):91-6.
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2001: Lin S; Duclos R I; Makriyannis A
Preparation of optically pure 4-(hydroxymethyl)-2-pentadecyl-1,3-dioxolanes and their corresponding phosphodiester ether lipid derivatives.
Chemistry and physics of lipids 2001;113(1-2):111-22.
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2001: Malan T P; Ibrahim M M; Deng H; Liu Q; Mata H P; Vanderah T; Porreca F; Makriyannis A
CB2 cannabinoid receptor-mediated peripheral antinociception.
Pain 2001;93(3):239-45.
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2001: Järbe T U; Lamb R J; Lin S; Makriyannis A
(R)-methanandamide and Delta 9-THC as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide.
Psychopharmacology 2001;156(4):369-80.
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2001: Goutopoulos A; Fan P; Khanolkar A D; Xie X Q; Lin S; Makriyannis A
Stereochemical selectivity of methanandamides for the CB1 and CB2 cannabinoid receptors and their metabolic stability.
Bioorganic & medicinal chemistry 2001;9(7):1673-84.
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2001: Simoneau I I; Hamza M S; Mata H P; Siegel E M; Vanderah T W; Porreca F; Makriyannis A; Malan T P
The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets.
Anesthesiology 2001;94(5):882-7.
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2001: Mavromoustakos T; Calogeropoulou T; Koufaki M; Kolocouris A; Daliani I; Demetzos C; Meng Z; Makriyannis A; Balzarini J; De Clercq E
Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers.
Journal of medicinal chemistry 2001;44(11):1702-9.
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2000: Cosenza M; Gifford A N; Gatley S J; Pyatt B; Liu Q; Makriyannis A; Volkow N D
Locomotor activity and occupancy of brain cannabinoid CB1 receptors by the antagonist/inverse agonist AM281.
Synapse (New York, N.Y.) 2000;38(4):477-82.
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2000: Khanolkar A D; Palmer S L; Makriyannis A
Molecular probes for the cannabinoid receptors.
Chemistry and physics of lipids 2000;108(1-2):37-52.
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2000: Harrington P E; Stergiades I A; Erickson J; Makriyannis A; Tius M A
Synthesis of functionalized cannabinoids.
The Journal of organic chemistry 2000;65(20):6576-82.
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2000: Palmer S L; Khanolkar A D; Makriyannis A
Natural and synthetic endocannabinoids and their structure-activity relationships.
Current pharmaceutical design 2000;6(13):1381-97.
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2000: Lamb R J; Järbe T U; Makriyannis A; Lin S; Goutopoulos A
Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing.
European journal of pharmacology 2000;398(2):251-8.
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2000: Järbe T U; Lamb R J; Lin S; Makriyannis A
Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats: a systematic replication.
Behavioural pharmacology 2000;11(1):81-6.
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1999: Gifford A N; Bruneus M; Lin S; Goutopoulos A; Makriyannis A; Volkow N D; Gatley S J
Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374).
European journal of pharmacology 1999;383(1):9-14.
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1999: Xie X Q; Han X W; Chen J Z; Eissenstat M; Makriyannis A
High-resolution NMR and computer modeling studies of the cannabimimetic aminoalkylindole prototype WIN-55212-2.
Journal of medicinal chemistry 1999;42(20):4021-7.
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1999: Khanolkar A D; Lu D; Fan P; Tian X; Makriyannis A
Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.
Bioorganic & medicinal chemistry letters 1999;9(15):2119-24.
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1999: Romero J; Berrendero F; García-Gil L; Lin S Y; Makriyannis A; Ramos J A; Fernández-Ruiz J J
Cannabinoid receptor and WIN-55,212-2-stimulated [35S]GTPgammaS binding and cannabinoid receptor mRNA levels in several brain structures of adult male rats chronically exposed to R-methanandamide.
Neurochemistry international 1999;34(6):473-82.
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1999: Piomelli D; Beltramo M; Glasnapp S; Lin S Y; Goutopoulos A; Xie X Q; Makriyannis A
Structural determinants for recognition and translocation by the anandamide transporter.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5802-7.
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1999: Lang W; Qin C; Lin S; Khanolkar A D; Goutopoulos A; Fan P; Abouzid K; Meng Z; Biegel D; Makriyannis A
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.
Journal of medicinal chemistry 1999;42(5):896-902.
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1999: Lan R; Liu Q; Fan P; Lin S; Fernando S R; McCallion D; Pertwee R; Makriyannis A
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.
Journal of medicinal chemistry 1999;42(4):769-76.
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1999: Gifford A N; Bruneus M; Gatley S J; Lan R; Makriyannis A; Volkow N D
Large receptor reserve for cannabinoid actions in the central nervous system.
The Journal of pharmacology and experimental therapeutics 1999;288(2):478-83.
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1999: Lan R; Gatley J; Lu Q; Fan P; Fernando S R; Volkow N D; Pertwee R; Makriyannis A
Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a potential human SPECT ligand.
AAPS pharmSci 1999;1(2):E4.
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1999: Khanolkar A D; Makriyannis A
Structure-activity relationships of anandamide, an endogenous cannabinoid ligand.
Life sciences 1999;65(6-7):607-16.
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1999: González S; Romero J; de Miguel R; Lastres-Becker I; Villanua M A; Makriyannis A; Ramos J A; Fernández-Ruiz J J
Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide.
Life sciences 1999;65(3):327-36.
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1998: Järbe T U; Lamb R J; Makriyannis A; Lin S; Goutopoulos A
Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats.
Psychopharmacology 1998;140(4):519-22.
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1998: Lin S; Khanolkar A D; Fan P; Goutopoulos A; Qin C; Papahadjis D; Makriyannis A
Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability.
Journal of medicinal chemistry 1998;41(27):5353-61.
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1998: de Miguel R; Romero J; Muñoz R M; García-Gil L; González S; Villanua M A; Makriyannis A; Ramos J A; Fernández-Ruiz J J
Effects of cannabinoids on prolactin and gonadotrophin secretion: involvement of changes in hypothalamic gamma-aminobutyric acid (GABA) inputs.
Biochemical pharmacology 1998;56(10):1331-8.
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1998: Drake D J; Jensen R S; Busch-Petersen J; Kawakami J K; Concepcion Fernandez-Garcia M; Fan P; Makriyannis A; Tius M A
Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues.
Journal of medicinal chemistry 1998;41(19):3596-608.
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1998: Qin C; Lin S; Lang W; Goutopoulos A; Pavlopoulos S; Mauri F; Makriyannis A
Determination of anandamide amidase activity using ultraviolet-active amine derivatives and reverse-phase high-performance liquid chromatography.
Analytical biochemistry 1998;261(1):8-15.
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1998: Carriero D; Aberman J; Lin S Y; Hill A; Makriyannis A; Salamone J D
A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing.
Psychopharmacology 1998;137(2):147-56.
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1998: Järbe T U; Sheppard R; Lamb R J; Makriyannis A; Lin S; Goutopoulos A
Effects of delta-9-tetrahydrocannabinol and (R)-methanandamide on open-field behavior in rats.
Behavioural pharmacology 1998;9(2):169-74.
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1998: Papahatjis D P; Kourouli T; Abadji V; Goutopoulos A; Makriyannis A
Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols.
Journal of medicinal chemistry 1998;41(7):1195-200.
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1998: Xie X Q; Pavlopoulos S; DiMeglio C M; Makriyannis A
Conformational studies on a diastereoisomeric pair of tricyclic nonclassical cannabinoids by NMR spectroscopy and computer molecular modeling.
Journal of medicinal chemistry 1998;41(2):167-74.
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1998: Gatley S J; Lan R; Volkow N D; Pappas N; King P; Wong C T; Gifford A N; Pyatt B; Dewey S L; Makriyannis A
Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo.
Journal of neurochemistry 1998;70(1):417-23.
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1998: Landsman R S; Makriyannis A; Deng H; Consroe P; Roeske W R; Yamamura H I
AM630 is an inverse agonist at the human cannabinoid CB1 receptor.
Life sciences 1998;62(9):PL109-13.
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1997: Calignano A; La Rana G; Makriyannis A; Lin S Y; Beltramo M; Piomelli D
Inhibition of intestinal motility by anandamide, an endogenous cannabinoid.
European journal of pharmacology 1997;340(2-3):R7-8.
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1997: Gifford A N; Tang Y; Gatley S J; Volkow N D; Lan R; Makriyannis A
Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices.
Neuroscience letters 1997;238(1-2):84-6.
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1997: Calignano A; La Rana G; Beltramo M; Makriyannis A; Piomelli D
Potentiation of anandamide hypotension by the transport inhibitor, AM404.
European journal of pharmacology 1997;337(1):R1-2.
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1997: Beltramo M; Stella N; Calignano A; Lin S Y; Makriyannis A; Piomelli D
Functional role of high-affinity anandamide transport, as revealed by selective inhibition.
Science (New York, N.Y.) 1997;277(5329):1094-7.
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1997: Fernández-Ruiz J J; Muñoz R M; Romero J; Villanua M A; Makriyannis A; Ramos J A
Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics.
Biochemical pharmacology 1997;53(12):1919-27.
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1997: Lin S; Duclos R I; Makriyannis A
Syntheses of 1,2-di-O-palmitoyl-sn-glycero-3-phosphocholine (DPPC) and analogs with 13C- and 2H-labeled choline head groups.
Chemistry and physics of lipids 1997;86(2):171-81.
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1997: Hosohata Y; Quock R M; Hosohata K; Makriyannis A; Consroe P; Roeske W R; Yamamura H I
AM630 antagonism of cannabinoid-stimulated [35S]GTP gamma S binding in the mouse brain.
European journal of pharmacology 1997;321(1):R1-3.
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1997: Gatley S J; Lan R; Pyatt B; Gifford A N; Volkow N D; Makriyannis A
Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors.
Life sciences 1997;61(14):PL 191-7.
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1997: Hosohata K; Quock R M; Hosohata Y; Burkey T H; Makriyannis A; Consroe P; Roeske W R; Yamamura H I
AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain.
Life sciences 1997;61(9):PL115-8.
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1997: Xie X Q; Moring J; Makriyannis A
Differential scanning calorimetry and small angle x-ray diffraction study of the interaction of (R)-PAF, (R)-ET-18-OME and (R)-Lyso-PAF with model membranes.
Life sciences 1997;61(9):909-23.
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1996: Mavromoustakos T; Theodoropoulou E; Yang D P; Lin S Y; Koufaki M; Makriyannis A
The conformational properties of the antineoplastic ether lipid 1-thiohexadecyl-2-O-methyl-S-glycero-3-phosphocholine.
Chemistry and physics of lipids 1996;84(1):21-34.
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1996: Khanolkar A D; Abadji V; Lin S; Hill W A; Taha G; Abouzid K; Meng Z; Fan P; Makriyannis A
Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.
Journal of medicinal chemistry 1996;39(22):4515-9.
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1996: Busch-Petersen J; Hill W A; Fan P; Khanolkar A; Xie X Q; Tius M A; Makriyannis A
Unsaturated side chain beta-11-hydroxyhexahydrocannabinol analogs.
Journal of medicinal chemistry 1996;39(19):3790-6.
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1996: Tsotinis A; Calogeropoulou T; Koufaki M; Souli C; Balzarini J; De Clercq E; Makriyannis A
Synthesis and antiretroviral evaluation of new alkoxy and aryloxy phosphate derivatives of 3'-azido-3'-deoxythymidine.
Journal of medicinal chemistry 1996;39(17):3418-22.
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1996: Xie X; Lin S; Moring J; Makriyannis A
Interdigitation of bilayers from ether lipid analogs: (R)-PAF, (R)-Lyso-PAF and the antineoplastic (R)-ET-18-OMe.
Biochimica et biophysica acta 1996;1283(1):111-8.
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1996: Gatley S J; Gifford A N; Volkow N D; Lan R; Makriyannis A
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors.
European journal of pharmacology 1996;307(3):331-8.
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1996: Koufaki M; Polychroniou V; Calogeropoulou T; Tsotinis A; Drees M; Fiebig H H; LeClerc S; Hendriks H R; Makriyannis A
Alkyl and alkoxyethyl antineoplastic phospholipids.
Journal of medicinal chemistry 1996;39(13):2609-14.
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1996: Mavromoustakos T; Theodoropoulou E; Papahatjis D; Kourouli T; Yang D P; Trumbore M; Makriyannis A
Studies on the thermotropic effects of cannabinoids on phosphatidylcholine bilayers using differential scanning calorimetry and small angle X-ray diffraction.
Biochimica et biophysica acta 1996;1281(2):235-44.
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1996: Lang W; Qin C; Hill W A; Lin S; Khanolkar A D; Makriyannis A
High-performance liquid chromatographic determination of anandamide amidase activity in rat brain microsomes.
Analytical biochemistry 1996;238(1):40-5.
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1996: Xie X Q; Melvin L S; Makriyannis A
The conformational properties of the highly selective cannabinoid receptor ligand CP-55,940.
The Journal of biological chemistry 1996;271(18):10640-7.
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1996: Mavromoustakos T; Yang D P; Makriyannis A
Topography and thermotropic properties of cannabinoids in brain sphingomyelin bilayers.
Life sciences 1996;59(23):1969-79.
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1996: Romero J; García-Palomero E; Lin S Y; Ramos J A; Makriyannis A; Fernández-Ruiz J J
Extrapyramidal effects of methanandamide, an analog of anandamide, the endogenous CB1 receptor ligand.
Life sciences 1996;58(15):1249-57.
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1995: Mavromoustakos T; Yang D P; Makriyannis A
Effects of the anesthetic steroid alphaxalone and its inactive delta 16-analog on the thermotropic properties of membrane bilayers. A model for membrane perturbation.
Biochimica et biophysica acta 1995;1239(2):257-64.
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1995: Mavromoustakos T; Yang D P; Makriyannis A
Small angle X-ray diffraction and differential scanning calorimetric studies on O-methyl-(-)-delta 8-tetrahydrocannabinol and its 5' iodinated derivative in membrane bilayers.
Biochimica et biophysica acta 1995;1237(2):183-8.
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1995: Pertwee R G; Fernando S R; Griffin G; Abadji V; Makriyannis A
Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations.
European journal of pharmacology 1995;272(1):73-8.
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1995: Tius M A; Hill W A; Zou X L; Busch-Petersen J; Kawakami J K; Fernandez-Garcia M C; Drake D J; Abadji V; Makriyannis A
Classical/non-classical cannabinoid hybrids; stereochemical requirements for the southern hydroxyalkyl chain.
Life sciences 1995;56(23-24):2007-12.
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1995: Xie X Q; Eissenstat M; Makriyannis A
Common cannabimimetic pharmacophoric requirements between aminoalkyl indoles and classical cannabinoids.
Life sciences 1995;56(23-24):1963-70.
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1995: Morse K L; Fournier D J; Li X; Grzybowska J; Makriyannis A
A novel electrophilic high affinity irreversible probe for the cannabinoid receptor.
Life sciences 1995;56(23-24):1957-62.
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1995: Pertwee R; Griffin G; Fernando S; Li X; Hill A; Makriyannis A
AM630, a competitive cannabinoid receptor antagonist.
Life sciences 1995;56(23-24):1949-55.
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1994: Duclos R I; Chia H H; Abdelmageed O H; Esber H; Fournier D J; Makriyannis A
Syntheses of racemic and nearly optically pure ether lipids and evaluation of in vitro antineoplastic activities.
Journal of medicinal chemistry 1994;37(24):4147-54.
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1994: Guo Y; Abadji V; Morse K L; Fournier D J; Li X; Makriyannis A
(-)-11-Hydroxy-7'-isothiocyanato-1',1'-dimethylheptyl-delta 8-THC: a novel, high-affinity irreversible probe for the cannabinoid receptor in the brain.
Journal of medicinal chemistry 1994;37(23):3867-70.
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1994: Mavromoustakos T; Yang D P; Makriyannis A
Topography of alphaxalone and delta 16-alphaxalone in membrane bilayers containing cholesterol.
Biochimica et biophysica acta 1994;1194(1):69-74.
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1994: Yan G; Yin D; Khanolkar A D; Compton D R; Martin B R; Makriyannis A
Synthesis and pharmacological properties of 11-hydroxy-3-(1',1'-dimethylheptyl)hexahydrocannabinol: a high-affinity cannabinoid agonist.
Journal of medicinal chemistry 1994;37(16):2619-22.
-
1994: Yin D; Khanolkar A D; Makriyannis A; Froimowitz M
Chiral resolution of 1,3-dimethyl-4-phenylpiperidine derivatives using high-performance liquid chromatography with a chiral stationary phase.
Journal of chromatography. A 1994;678(1):176-9.
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1994: Abadji V; Lin S; Taha G; Griffin G; Stevenson L A; Pertwee R G; Makriyannis A
(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.
Journal of medicinal chemistry 1994;37(12):1889-93.
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1994: Xie X Q; Yang D P; Melvin L S; Makriyannis A
Conformational analysis of the prototype nonclassical cannabinoid CP-47,497, using 2D NMR and computer molecular modeling.
Journal of medicinal chemistry 1994;37(10):1418-26.
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1993: Martin B R; Compton D R; Semus S F; Lin S; Marciniak G; Grzybowska J; Charalambous A; Makriyannis A
Pharmacological evaluation of iodo and nitro analogs of delta 8-THC and delta 9-THC.
Pharmacology, biochemistry, and behavior 1993;46(2):295-301.
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1993: DiMeglio C M; Froimowitz M; Makriyannis A
Conformational analysis of the opioid phenylmorphan and its 9 alpha-methyl analogue in solution using high-resolution nuclear magnetic resonance spectroscopy.
Pharmaceutical research 1993;10(8):1200-5.
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1993: Makriyannis A; DiMeglio C M; DeJong A P; el-Khateeb S
Hallucinogenic receptor models: interaction of imidazolium chloride with amphetamine analogs.
Molecular pharmacology 1993;43(1):78-83.
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1993: Yang D P; Mavromoustakos T; Makriyannis A
Small angle X-ray diffraction studies of (-)-delta 8-tetrahydrocannabinol and its O-methyl analog in membranes.
Life sciences 1993;53(7):PL117-22.
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1993: Makriyannis A
Probes for the cannabinoid sites of action.
NIDA research monograph 1993;134():253-67.
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1992: Froimowitz M; DiMeglio C M; Makriyannis A
Conformational preferences of the kappa-selective opioid agonist U50488. A combined molecular mechanics and nuclear magnetic resonance study.
Journal of medicinal chemistry 1992;35(17):3085-94.
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1992: Charalambous A; Yan G; Houston D B; Howlett A C; Compton D R; Martin B R; Makriyannis A
5'-Azido-delta 8-THC: a novel photoaffinity label for the cannabinoid receptor.
Journal of medicinal chemistry 1992;35(16):3076-9.
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1992: Yang D P; Mavromoustakos T; Beshah K; Makriyannis A
Amphipathic interactions of cannabinoids with membranes. A comparison between delta 8-THC and its O-methyl analog using differential scanning calorimetry, X-ray diffraction and solid state 2H-NMR.
Biochimica et biophysica acta 1992;1103(1):25-36.
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1991: Yang D P; Banijamali A; Charalambous A; Marciniak G; Makriyannis A
Solid state 2H-NMR as a method for determining the orientation of cannabinoid analogs in membranes.
Pharmacology, biochemistry, and behavior 1991;40(3):553-7.
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1991: Mavromoustakos T; Yang D P; Broderick W; Fournier D; Makriyannis A
Small angle x-ray diffraction studies on the topography of cannabinoids in synaptic plasma membranes.
Pharmacology, biochemistry, and behavior 1991;40(3):547-52.
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1991: Charalambous A; Lin S; Marciniak G; Banijamali A; Friend F L; Compton D R; Martin B R; Makriyannis A
Pharmacological evaluation of halogenated delta 8-THC analogs.
Pharmacology, biochemistry, and behavior 1991;40(3):509-12.
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1991: Charalambous A; Marciniak G; Shiue C Y; Dewey S L; Schlyer D J; Wolf A P; Makriyannis A
PET studies in the primate brain and biodistribution in mice using (-)-5'-18F-delta 8-THC.
Pharmacology, biochemistry, and behavior 1991;40(3):503-7.
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1991: Makriyannis A; DiMeglio C M; Fesik S W
Anesthetic steroid mobility in model membrane preparations as examined by high-resolution 1H and 2H NMR spectroscopy.
Journal of medicinal chemistry 1991;34(5):1700-3.
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1991: Burstein S H; Audette C A; Charalambous A; Doyle S A; Guo Y; Hunter S A; Makriyannis A
Detection of cannabinoid receptors by photoaffinity labelling.
Biochemical and biophysical research communications 1991;176(1):492-7.
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1991: Makriyannis A; Yang D P; Mavromoustakos T
Combined use of solid-state nuclear magnetic resonance spectroscopy, small-angle x-ray diffraction, and differential scanning calorimetry in studies of cannabinoid: membrane interactions.
NIDA research monograph 1991;112():106-28.
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1990: Melchior D L; Carruthers A; Makriyannis A; Duclos R I; Abdel-Mageed O H
Alterations in red blood cell sugar transport by nanomolar concentrations of alkyl lysophospholipid.
Biochimica et biophysica acta 1990;1028(1):1-8.
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1990: Makriyannis A; Yang D P; Griffin R G; Das Gupta S K
The perturbation of model membranes by (-)-delta 9-tetrahydrocannabinol. Studies using solid-state 2H- and 13C-NMR.
Biochimica et biophysica acta 1990;1028(1):31-42.
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1990: Mavromoustakos T; Yang D P; Charalambous A; Herbette L G; Makriyannis A
Study of the topography of cannabinoids in model membranes using X-ray diffraction.
Biochimica et biophysica acta 1990;1024(2):336-44.
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1990: Abdelmageed O H; Duclos R I; Abushanab E; Makriyannis A
Chirospecific syntheses of 2H- and 13C-labeled 1-O-alkyl-2-O-alkyl'-sn-glycero-3-phosphoethanolamines and 1-O-alkyl-2-O-alkyl'-sn-glycero-3-phosphocholines.
Chemistry and physics of lipids 1990;54(1):49-59.
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1990: Makriyannis A; Yang D P; Mavromoustakos T
The molecular features of membrane perturbation by anaesthetic steroids: a study using differential scanning calorimetry, small angle X-ray diffraction and solid state 2H NMR.
Ciba Foundation symposium 1990;153():172-84; discussion 185-9.
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1990: Makriyannis A; Rapaka R S
The molecular basis of cannabinoid activity.
Life sciences 1990;47(24):2173-84.
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1989: Makriyannis A; Banijamali A; Jarrell H C; Yang D P
The orientation of (-)-delta 9-tetrahydrocannabinol in DPPC bilayers as determined from solid-state 2H-NMR.
Biochimica et biophysica acta 1989;986(1):141-5.
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1989: Kriwacki R W; Makriyannis A
The conformational analysis of delta 9- and delta 9,11-tetrahydrocannabinols in solution using high resolution nuclear magnetic resonance spectroscopy.
Molecular pharmacology 1989;35(4):495-503.
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1988: Van der Schyf C J; Mavromoustakos T; Makriyannis A
The conformation of (-) 8 alpha and (-) 8 beta-hydroxy-delta 9-tetrahydrocannabinols and their interactions with model membranes.
Life sciences 1988;42(22):2231-9.
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1987: Makriyannis A; Rapaka R S
The medicinal chemistry of cannabinoids: an overview.
NIDA research monograph 1987;79():204-10.
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1987: Makriyannis A; Banijamali A; Van der Schyf C; Jarrell H
Interactions of cannabinoids with membranes. The role of cannabinoid stereochemistry and absolute configuration and the orientation of delta-9-THC in the membrane bilayer.
NIDA research monograph 1987;79():123-33.
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